CN111715167B - Preparation method and preparation equipment of acylated derivative of glucosamine - Google Patents
Preparation method and preparation equipment of acylated derivative of glucosamine Download PDFInfo
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- CN111715167B CN111715167B CN202010623202.7A CN202010623202A CN111715167B CN 111715167 B CN111715167 B CN 111715167B CN 202010623202 A CN202010623202 A CN 202010623202A CN 111715167 B CN111715167 B CN 111715167B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/95—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with stirrers having planetary motion, i.e. rotating about their own axis and about a sun axis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/75—Discharge mechanisms
- B01F35/754—Discharge mechanisms characterised by the means for discharging the components from the mixer
- B01F35/7547—Discharge mechanisms characterised by the means for discharging the components from the mixer using valves, gates, orifices or openings
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
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Abstract
The invention discloses a preparation method and preparation equipment of an acylated derivative of glucosamine, and relates to the technical field of preparation of acylated derivatives. The preparation method and the preparation equipment of the acylated derivative of glucosamine comprise a stirring device, wherein the stirring device comprises a feeding cylinder, a rotating plate and a rotating rod, a stirring barrel is arranged at the lower end of the feeding cylinder, a discharging device is arranged at the right end of the stirring barrel, a first connecting rod is arranged on the upper surface of the rotating plate, the lower surface of the first connecting rod is fixedly connected with the middle part of the upper surface of the rotating plate, two baffle rings are fixedly arranged at the lower end of the surface of the first connecting rod, a rotating block is arranged at the upper end of the first connecting rod, an electric device arranged inside a base drives the rotating rod to rotate, the rotating rod rotates to drive two first cross rods to rotate, the first cross rods drive two cross rods to rotate through third connecting rods, the first cross rods drive the stirring rods to rotate around the rotating rods through gears and clamping grooves, and multi-direction stirring.
Description
Technical Field
The invention relates to the technical field of preparation of acylated derivatives, in particular to a preparation method and preparation equipment of an acylated derivative of glucosamine.
Background
During the preparation of the acylated glucosamine derivative, usually, glucosamine hydrochloride is dissolved in pyridine, triethylamine is added, acetic anhydride is added under the stirring condition, the stirring reaction is finished for 1-3h, and then a reaction mixed solution is obtained.
Disclosure of Invention
The present invention is directed to a method for preparing an acylated derivative of glucosamine and an apparatus for preparing the same, which solve the problems set forth in the background art described above.
In order to achieve the purpose, the invention provides the following technical scheme: a preparation device of an acylated derivative of glucosamine comprises a stirring device, wherein the stirring device comprises a feeding cylinder, a rotating plate and a rotating rod, a stirring barrel is arranged at the lower end of the feeding cylinder, a discharging device is arranged at the right end of the stirring barrel, a first connecting rod is arranged on the upper surface of the rotating plate, the lower surface of the first connecting rod is fixedly connected with the middle part of the upper surface of the rotating plate, two baffle rings are fixedly arranged at the lower end of a rod face of the first connecting rod, circular grooves I are formed in the right ends of the upper surface and the lower surface of the rotating plate, a rotating block is arranged at the upper end of the first connecting rod, a sliding groove is formed in each of the front end, the rear end, the left end, the right end of the first connecting rod, the upper end of the rod face of the first connecting rod is fixedly connected with the middle part of the upper surface of the rotating block, a second connecting rod is arranged on the upper surface, the pin upper surface is provided with the quarter butt, the lower surface of quarter butt and the upper surface right-hand member fixed connection of pin, the face middle part of bull stick is provided with two horizontal poles one, two relative two sides of horizontal pole one respectively with both ends fixed connection around the bull stick face middle part, two horizontal poles one all are provided with a connecting rod three from both ends, two connecting rod three all are provided with a horizontal pole two from both ends, two horizontal pole two relative two sides respectively with two connecting rod three from both ends fixed connection, two connecting rod three close both ends respectively with two horizontal poles one from both ends articulated.
Preferably, the front end and the rear end of the upper surface and the lower surface of the two second transverse rods are respectively and fixedly provided with a stirring rod, two surfaces of the two second transverse rods, which are away from each other, are respectively provided with a first gear, and two opposite surfaces of the two first gears are respectively hinged with the middle parts of the two opposite surfaces of the two second transverse rods.
Preferably, the agitator includes ladle body, base and rectangular channel, and the rectangular channel setting is at the lower extreme of ladle body anchor ring right-hand member, and the upper end of rectangular channel is provided with perpendicular groove, and the upper surface mid portion of ladle body is provided with a circular slot two, and the lower surface mid portion of ladle body is provided with circular slot three, and the left end of circular slot two is provided with circular slot four, and the left end of circular slot four is provided with circular slot five, and the interior anchor ring mid portion of ladle body is provided with the annular, and the lower floor of annular evenly is provided with the draw-in groove.
Preferably, the middle part of the upper surface of the base is provided with a circular groove six, and the middle part of the right end of the ring surface of the base is provided with a square groove.
Preferably, discharging device includes a feed cylinder, connecting plate and conveyer belt, the upper surface of feed cylinder is provided with a picture peg, the picture peg left end is provided with a draw runner, the right surface of draw runner and the left fixed surface of picture peg are connected, the lower surface of feed cylinder is provided with the montant, the upper surface of montant is articulated with the lower surface right-hand member middle part of feed cylinder, the lower surface of montant is provided with gear two, the upper surface middle part and the montant lower fixed surface of gear two are connected, the right-hand member setting of conveyer belt is at the face middle part of montant, the left end of conveyer belt passes through the square groove setting in the base.
Preferably, the middle part of the front end of the upper surface of the connecting plate is provided with a pushing groove, the right end of the pushing groove is provided with two transverse grooves, a push rod is arranged in the pushing groove, the front end of the push rod is provided with a clamping rod, the left end of the rear surface of the clamping rod is hinged to the front surface of the push rod, the upper surface of the push rod is provided with a screw rod, the lower surface of the screw rod is hinged to the rear end of the upper surface of the push rod, a third gear is fixedly arranged at the lower end of the face of the screw rod, the third gear is meshed with the second.
Preferably, the lower surface of ladle body and the fixed surface of base are connected, go out the left surface of feed cylinder and the right-hand member fixed connection of rectangular channel, and the draw runner setting is in erecting the inslot, and the left end of connecting plate and the anchor ring right-hand member fixed connection of base, feed cylinder setting are in circular slot five.
Another technical problem to be solved by the present invention is to provide a method for preparing an acylated derivative of glucosamine, comprising the steps of:
1): dissolving glucosamine hydrochloride in pyridine;
2) (ii) a Dissolving glucosamine hydrochloride in pyridine, adding triethylamine, and stirring in a stirring barrel;
3): adding acetic anhydride under the condition of stirring, and stirring to react for 1-3 hours to obtain a reaction mixed solution from a discharging device.
Compared with the prior art, the invention has the beneficial effects that:
(1) according to the preparation method and the preparation equipment of the acylated derivative of the glucosamine, the rotating rod is driven to rotate by the electric device arranged inside the base, the rotating rod rotates to drive the first two transverse rods to rotate, the first transverse rod drives the second transverse rod to rotate through the third connecting rod, and the second transverse rod drives the stirring rod to rotate through the first gear and the clamping groove while rotating around the rotating rod, so that multi-directional stirring is formed to achieve a better stirring effect.
(2) This glucosamine acidylates preparation method and preparation facilities of derivative, the bull stick rotates and drives the pin and rotate, makes the quarter butt of pin upper surface can be along with rotating in the spout motion, can make the pin rotate the circle and just can drive the commentaries on classics piece and rotate once like this, changes the piece and drives the commentaries on classics board rotation through connecting rod one when rotating, in the material can get into the ladle body when the circular slot rotates to with feed cylinder lower surface, can make the material pour into and produce certain interval like this, makes the stirring more abundant.
(3) After the stirring is finished, the push rod is pushed by rotating the clamping rod, the gear III is meshed with the gear II, the rotating rod rotates to drive the conveying belt to operate, the gear II rotates to drive the gear III to rotate, the gear III drives the screw rod to rotate, the screw rod enables the insertion plate to move upwards through threads, mixed liquid after stirring can be discharged, and after the discharging is finished, the insertion plate can be sealed by the push rod to push away the gear III, so that the next stirring can be carried out continuously.
(4) According to the preparation method and the preparation equipment of the acylated derivative of glucosamine, the stirring and feeding stages can be simultaneously controlled through the rotating rod, the internal structure of the equipment is simplified, and the equipment is convenient to overhaul and maintain.
(5) The preparation method and the preparation equipment of the acylated derivative of glucosamine utilize the conveyor belt to ensure that the rotating rod can provide the power required by the discharging device when needed, thereby achieving the effect of one rod with multiple purposes.
(6) According to the preparation method and the preparation equipment of the acylated derivative of glucosamine, the lifting of the inserting plate is controlled through the discharging device, the inserting plate does not need to be pulled up manually, and the phenomenon that the production quality is affected due to the fact that the inserting plate is touched to pollute reaction mixed liquid is avoided.
(7) According to the preparation method and the preparation equipment of the acylated derivative of glucosamine, the position of the clamping rod is limited by the transverse groove, so that the push rod is not easy to move, the phenomenon that the operation of the discharging device is influenced by the translocation of the push rod when the discharging device operates is avoided, and the stability of the equipment is improved.
Drawings
FIG. 1 is a schematic view showing the overall structure of a process for producing an acylated derivative of glucosamine and an apparatus for producing the same according to the present invention;
FIG. 2 is a schematic structural view of the stirring apparatus of FIG. 1 according to the present invention;
FIG. 3 is a schematic structural view of the mixing tank shown in FIG. 1 according to the present invention;
FIG. 4 is a schematic structural view of the discharging device shown in FIG. 1 according to the present invention;
FIG. 5 is an enlarged view of the structure at A in FIG. 3 according to the present invention;
FIG. 6 is an enlarged view of the structure of FIG. 4 at B according to the present invention;
FIG. 7 is an enlarged view of the structure of FIG. 2 at C;
FIG. 8 is an enlarged view of FIG. 2 at D according to the present invention;
fig. 9 is an enlarged view of the structure at E in fig. 2 according to the present invention.
In the figure: 1 stirring device, 2 stirring barrel, 3 discharging device, 11 rotating plate, 12 stirring rod, 13 connecting rod III, 14 rotating rod, 15 circular groove I, 16 feeding barrel, 17 rotating block, 19 baffle ring, 110 connecting rod I, 111 sliding groove, 112 baffle rod, 113 short rod, 114 connecting rod II, 115 gear I, 116 cross rod I, 117 cross rod II, 21 barrel body, 22 circular groove II, 23 circular groove III, 24 base, 25 circular groove six, 26 square groove, 27 circular groove four, 28 circular groove, 29 circular groove five, 210 clamping groove, 211 vertical groove, 212 rectangular groove, 31 discharging barrel, 32 vertical rod, 33 gear II, 34 connecting plate, 35 gear III, 36 conveyor belt, 37 screw rod, 38 screw thread, 39 sliding strip, 310 inserting plate, 311 transverse groove, 312 pushing groove, 313 push rod, 314 clamping rod.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1 to 9, the present invention provides a technical solution: a preparation method of an acylated derivative of glucosamine and preparation equipment thereof comprise a stirring device 1, wherein the stirring device 1 comprises a feeding cylinder 16, a rotating plate 11 and a rotating rod 14, the lower end of the feeding cylinder 16 is provided with a stirring barrel 2, the stirring barrel 2 comprises a barrel body 21, a base 24 and a rectangular groove 212, the rectangular groove 212 is arranged at the lower end of the right end of the ring surface of the barrel body 21, the upper end of the rectangular groove 212 is provided with a vertical groove 211, the middle part of the upper surface of the barrel body 21 is provided with a circular groove II 22, the middle part of the lower surface of the barrel body 21 is provided with a circular groove III 23, the left end of the circular groove II 22 is provided with a circular groove IV 27, the left end of the circular groove IV 27 is provided with a circular groove V29, the middle part of the inner ring surface of the barrel body 21 is provided with a circular groove 28, the upper surface and the lower surface of the circular groove 28 are uniformly provided with clamping grooves 210, the middle, the right end of the mixing barrel 2 is provided with a discharging device 3, the discharging device 3 comprises a discharging barrel 31, a connecting plate 34 and a conveyor belt 36, the upper surface of the discharging barrel 31 is provided with an inserting plate 310, the left end of the inserting plate 310 is provided with a slide bar 39, the right surface of the slide bar 39 is fixedly connected with the left surface of the inserting plate 310, the lower surface of the discharging barrel 31 is provided with a vertical bar 32, the upper surface of the vertical bar 32 is hinged with the middle part of the right end of the lower surface of the discharging barrel 31, the lower surface of the vertical bar 32 is provided with a gear wheel 33, the middle part of the upper surface of the gear wheel 33 is fixedly connected with the lower surface of the vertical bar 32, the right end of the conveyor belt 36 is arranged at the middle part of the face of the vertical bar 32, the left end of the conveyor belt 36 is arranged in the base 24 through a square groove 26, the middle part, a clamping rod 314 is arranged at the front end of the push rod 313, the left end of the rear surface of the clamping rod 314 is hinged with the front surface of the push rod 313, a screw rod 37 is arranged on the upper surface of the push rod 313, the lower surface of the screw rod 37 is hinged with the rear end of the upper surface of the push rod 313, a third gear 35 is fixedly arranged at the lower end of a rod surface of the screw rod 37, the third gear 35 is meshed with a second gear 33, threads 38 are arranged at the upper end of a rod surface of the screw rod 37, a first connecting rod 110 is arranged on the upper surface of the rotating plate 11, the lower surface of the first connecting rod 110 is fixedly connected with the middle part of the upper surface of the rotating plate 11, two retaining rings 19 are fixedly arranged at the lower end of the rod surface of the first connecting rod 110, a first circular groove 15 is arranged at the upper ends of the upper surface and the lower surface of the rotating plate 11, a rotating block 17 is arranged at the upper end of the first connecting rod, the lower surface of the second connecting rod 114 is fixedly connected with the middle part of the upper surface of the rotating rod 14, the right end of the second connecting rod 114 is provided with a stop rod 112, the middle part of the upper surface and the lower surface of the left end of the stop rod 112 is fixedly connected with the rod surface of the second connecting rod 114, the upper surface of the stop rod 112 is provided with a short rod 113, the lower surface of the short rod 113 is fixedly connected with the right end of the upper surface of the stop rod 112, the middle part of the rod surface of the rotating rod 14 is provided with two first cross rods 116, two opposite surfaces of the first cross rods 116 are respectively and fixedly connected with the front end and the rear end of the middle part of the rod surface of the rotating rod 14, two separated ends of the first cross rods 116 are respectively provided with a third connecting rod 13, two separated ends of the two third connecting rods 13 are respectively provided with a second cross rod 117, two opposite surfaces of the two second cross rods 117, the front end and the rear end of the upper surface and the lower surface of the two second cross rods 117 are respectively and fixedly provided with a stirring rod 12, two opposite surfaces of the two second cross rods 117 are respectively provided with a first gear 115, two opposite surfaces of the first gear 115 are respectively hinged with the middle parts of the two opposite surfaces of the two second cross rods 117, the lower surface of the barrel body 21 is fixedly connected with the upper surface of the base 24, the left surface of the discharging barrel 31 is fixedly connected with the right end of the rectangular groove 212, the sliding strip 39 is arranged in the vertical groove 211, the left end of the connecting plate 34 is fixedly connected with the right end of the ring surface of the base 24, and the feeding barrel 16 is arranged in the five circular grooves 29.
The working principle is as follows: in the steps of dissolving glucosamine hydrochloride in pyridine, adding triethylamine, adding acetic anhydride under stirring, stirring for reaction for 1-3h, and then obtaining a reaction mixed solution, an electric device arranged in a base 24 is used for driving a rotating rod 14 to rotate, the rotating rod 14 rotates to drive two first cross rods 116 to rotate, the first cross rod 116 drives a second cross rod 117 to rotate through a third connecting rod 13, the second cross rod 117 drives a stirring rod 12 to rotate through a first gear 115 and a clamping groove 210 while rotating around the rotating rod 14, multi-directional stirring is formed to achieve better stirring effect, the rotating rod 14 rotates to drive a stop rod 112 to rotate, so that a short rod 113 on the upper surface of the stop rod 112 can move in a sliding groove 111 along with rotation, and the stop rod 112 can drive a rotating block 17 to rotate once per rotation, when the rotating block 17 rotates, the rotating plate 11 is driven to rotate through the first connecting rod 110, when the first circular groove 15 rotates to the position where the first circular groove is located on the lower surface of the feeding cylinder 16, materials can enter the cylinder body 21, the materials can be poured into the cylinder body at a certain interval, after stirring is completed, the push rod 313 is pushed through rotation of the clamping rod 314, the third gear 35 is meshed with the second gear 33, the rotating rod 14 rotates to drive the conveying belt 36 to operate, the second gear 33 rotates to drive the third gear 35 to rotate, the third gear 35 drives the screw rod 37 to rotate, the screw rod 37 enables the inserting plate 310 to move upwards through the threads 38, mixed liquid after stirring can be discharged, after discharging is completed, the inserting plate 310 can seal the discharging cylinder 31 again through pushing away from the third gear 35 through the push rod 313, and accordingly next stirring can.
A process for the preparation of acylated derivatives of glucosamine comprising the steps of:
1): dissolving glucosamine hydrochloride in pyridine;
2) (ii) a Dissolving glucosamine hydrochloride in pyridine, adding triethylamine, and stirring in a stirring barrel 2;
3): adding acetic anhydride under the condition of stirring, and stirring to react for 1-3 hours to obtain a reaction mixed solution from a discharging device 3.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. An apparatus for the preparation of acylated derivatives of glucosamine, comprising stirring means (1), characterized in that: the stirring device (1) comprises a feeding cylinder (16), a rotating plate (11) and a rotating rod (14), a stirring barrel (2) is arranged at the lower end of the feeding cylinder (16), a discharging device (3) is arranged at the right end of the stirring barrel (2), a first connecting rod (110) is arranged on the upper surface of the rotating plate (11), the lower surface of the first connecting rod (110) is fixedly connected with the middle part of the upper surface of the rotating plate (11), two baffle rings (19) are fixedly arranged at the lower end of a rod surface of the first connecting rod (110), a first circular groove (15) is arranged at the right end of the upper surface and the lower surface of the rotating plate (11), a rotating block (17) is arranged at the upper end of the first connecting rod (110), a sliding groove (111) is formed in each of the front end, the rear end, the left end, the right end and the front end;
a second connecting rod (114) is arranged on the upper surface of the rotating rod (14), the lower surface of the second connecting rod (114) is fixedly connected with the middle part of the upper surface of the rotating rod (14), a stop lever (112) is arranged at the right end of the second connecting rod (114), the middle parts of the upper surface and the lower surface of the left end of the stop lever (112) are fixedly connected with the face of the second connecting rod (114), a short rod (113) is arranged on the upper surface of the stop lever (112), and the lower surface of the short rod (113) is fixedly connected with the right end of the upper surface of the stop lever (112);
the stirring barrel (2) comprises a barrel body (21), a base (24) and a rectangular groove (212), the rectangular groove (212) is arranged at the lower end of the right end of the ring surface of the barrel body (21), a vertical groove (211) is arranged at the upper end of the rectangular groove (212), a circular groove II (22) is arranged in the middle of the upper surface of the barrel body (21), a circular groove III (23) is arranged in the middle of the lower surface of the barrel body (21), a circular groove IV (27) is arranged at the left end of the circular groove II (22), a circular groove V (29) is arranged at the left end of the circular groove IV (27), a circular groove (28) is arranged in the middle of the inner ring surface of the barrel body (21), clamping grooves (210) are uniformly arranged on the upper surface and the lower surface of the circular groove II (28), a circular groove VI (25) is arranged in the middle of the upper surface of the base (24), and;
the discharging device (3) comprises a discharging barrel (31), a connecting plate (34) and a conveying belt (36), an inserting plate (310) is arranged on the upper surface of the discharging barrel (31), a sliding strip (39) is arranged at the left end of the inserting plate (310), the right surface of the sliding strip (39) is fixedly connected with the left surface of the inserting plate (310), a vertical rod (32) is arranged on the lower surface of the discharging barrel (31), the upper surface of the vertical rod (32) is hinged with the middle part of the right end of the lower surface of the discharging barrel (31), a second gear (33) is arranged on the lower surface of the vertical rod (32), the middle part of the upper surface of the second gear (33) is fixedly connected with the lower surface of the vertical rod (32), the right end of the conveying belt (36) is arranged on the middle part of the rod surface of the vertical rod (32), and the left end of the;
a push groove (312) is formed in the middle of the front end of the upper surface of the connecting plate (34), two transverse grooves (311) are formed in the right end of the push groove (312), a push rod (313) is arranged in the push groove (312), a clamping rod (314) is arranged at the front end of the push rod (313), the left end of the rear surface of the clamping rod (314) is hinged to the front surface of the push rod (313), a screw rod (37) is arranged on the upper surface of the push rod (313), the lower surface of the screw rod (37) is hinged to the rear end of the upper surface of the push rod (313), a third gear (35) is fixedly arranged at the lower end of the rod surface of the screw rod (37), the third gear (35) is meshed with the second gear (33), and threads (38) are;
the lower surface of the barrel body (21) is fixedly connected with the upper surface of the base (24), the left surface of the discharging barrel (31) is fixedly connected with the right end of the rectangular groove (212), the sliding strip (39) is arranged in the vertical groove (211), the left end of the connecting plate (34) is fixedly connected with the right end of the ring surface of the base (24), and the feeding barrel (16) is arranged in the circular groove five (29).
2. The apparatus for the preparation of acylated derivatives of glucosamine according to claim 1, wherein: the middle part of the face of the rotating rod (14) is provided with two first cross rods (116), two opposite faces of the first cross rods (116) are fixedly connected with the front end and the rear end of the middle part of the face of the rotating rod (14) respectively, two ends, away from each other, of the first cross rods (116) are provided with three connecting rods (13), two ends, away from each other, of the three connecting rods (13) are provided with two cross rods (117), two opposite faces of the two cross rods (117) are fixedly connected with two ends, away from each other, of the two connecting rods (13), and two close ends of the two connecting rods (13) are hinged with two ends, away from each other, of the two cross rods (116) respectively.
3. The apparatus for the preparation of acylated derivatives of glucosamine according to claim 2, wherein: the front end and the rear end of the upper surface and the lower surface of the two second transverse rods (117) are respectively and fixedly provided with a stirring rod (12), two surfaces of the two second transverse rods (117) which are away from each other are respectively provided with a first gear (115), and two opposite surfaces of the first gear (115) are respectively hinged with the middle parts of the two opposite surfaces of the two second transverse rods (117).
4. A process for the preparation of acylated derivatives of glucosamine, characterized in that: a production apparatus using an acylated derivative of glucosamine according to any one of claims 1 to 3, comprising the steps of:
1): dissolving glucosamine hydrochloride in pyridine;
2) (ii) a Dissolving glucosamine hydrochloride in pyridine, adding triethylamine, and stirring in a stirring barrel (2);
3): adding acetic anhydride under the condition of stirring, and obtaining reaction mixed liquid from a discharging device (3) after stirring and reacting for 1-3 hours.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010623202.7A CN111715167B (en) | 2020-07-01 | 2020-07-01 | Preparation method and preparation equipment of acylated derivative of glucosamine |
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| CN202010623202.7A CN111715167B (en) | 2020-07-01 | 2020-07-01 | Preparation method and preparation equipment of acylated derivative of glucosamine |
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| CN111715167B true CN111715167B (en) | 2021-04-06 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1176795A (en) * | 1997-09-04 | 1999-03-23 | Japan Steel Works Ltd:The | Combination feeder provided with revolving device |
| CN206082239U (en) * | 2016-05-13 | 2017-04-12 | 成都易思科科技有限公司 | Multi -direction agitator |
| CN206415123U (en) * | 2017-01-21 | 2017-08-18 | 叶露阳 | A kind of stirred autoclave |
| CN108261999A (en) * | 2018-04-02 | 2018-07-10 | 胡琴 | A kind of petrochemical industry reaction kettle |
| CN207951274U (en) * | 2017-12-29 | 2018-10-12 | 焦作懋源新材料有限公司 | A kind of positioning device of printing ink dispersion machine |
| CN109718735A (en) * | 2019-02-15 | 2019-05-07 | 安庆市虹泰新材料有限责任公司 | Reaction kettle is used in a kind of mixing of modified polyamide resin raw material |
-
2020
- 2020-07-01 CN CN202010623202.7A patent/CN111715167B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1176795A (en) * | 1997-09-04 | 1999-03-23 | Japan Steel Works Ltd:The | Combination feeder provided with revolving device |
| CN206082239U (en) * | 2016-05-13 | 2017-04-12 | 成都易思科科技有限公司 | Multi -direction agitator |
| CN206415123U (en) * | 2017-01-21 | 2017-08-18 | 叶露阳 | A kind of stirred autoclave |
| CN207951274U (en) * | 2017-12-29 | 2018-10-12 | 焦作懋源新材料有限公司 | A kind of positioning device of printing ink dispersion machine |
| CN108261999A (en) * | 2018-04-02 | 2018-07-10 | 胡琴 | A kind of petrochemical industry reaction kettle |
| CN109718735A (en) * | 2019-02-15 | 2019-05-07 | 安庆市虹泰新材料有限责任公司 | Reaction kettle is used in a kind of mixing of modified polyamide resin raw material |
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| CN111715167A (en) | 2020-09-29 |
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