CN111714202A - Tumor ablation monitoring assembly, device and system - Google Patents
Tumor ablation monitoring assembly, device and system Download PDFInfo
- Publication number
- CN111714202A CN111714202A CN201910203845.3A CN201910203845A CN111714202A CN 111714202 A CN111714202 A CN 111714202A CN 201910203845 A CN201910203845 A CN 201910203845A CN 111714202 A CN111714202 A CN 111714202A
- Authority
- CN
- China
- Prior art keywords
- ablation
- monitoring
- tissue cells
- tumor
- target tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002679 ablation Methods 0.000 title claims abstract description 149
- 238000012544 monitoring process Methods 0.000 title claims abstract description 127
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 76
- 230000002779 inactivation Effects 0.000 claims abstract description 32
- 230000000149 penetrating effect Effects 0.000 claims abstract description 3
- 210000004027 cell Anatomy 0.000 claims description 82
- 239000000126 substance Substances 0.000 claims description 48
- 238000011282 treatment Methods 0.000 claims description 41
- 230000006378 damage Effects 0.000 claims description 34
- 238000004458 analytical method Methods 0.000 claims description 20
- 238000001514 detection method Methods 0.000 claims description 20
- 238000011298 ablation treatment Methods 0.000 claims description 15
- 239000000523 sample Substances 0.000 claims description 12
- 230000004071 biological effect Effects 0.000 claims description 9
- 238000004891 communication Methods 0.000 claims description 5
- 230000001276 controlling effect Effects 0.000 claims description 5
- 238000003860 storage Methods 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 3
- 239000013307 optical fiber Substances 0.000 claims 3
- 210000003701 histiocyte Anatomy 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 16
- 210000001519 tissue Anatomy 0.000 description 82
- 239000000835 fiber Substances 0.000 description 9
- 230000003287 optical effect Effects 0.000 description 9
- 239000000203 mixture Substances 0.000 description 7
- 230000005540 biological transmission Effects 0.000 description 6
- 238000002591 computed tomography Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 238000002595 magnetic resonance imaging Methods 0.000 description 5
- 238000001959 radiotherapy Methods 0.000 description 5
- 238000002512 chemotherapy Methods 0.000 description 4
- 238000003384 imaging method Methods 0.000 description 4
- 208000003174 Brain Neoplasms Diseases 0.000 description 3
- 238000010317 ablation therapy Methods 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 238000004088 simulation Methods 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- 238000001069 Raman spectroscopy Methods 0.000 description 2
- 238000002583 angiography Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000003625 skull Anatomy 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 239000002912 waste gas Substances 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 208000018380 Chemical injury Diseases 0.000 description 1
- 206010019695 Hepatic neoplasm Diseases 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 208000019155 Radiation injury Diseases 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 210000002418 meninge Anatomy 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012806 monitoring device Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000007674 radiofrequency ablation Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00898—Alarms or notifications created in response to an abnormal condition
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plasma & Fusion (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Laser Surgery Devices (AREA)
Abstract
The invention relates to a tumor ablation monitoring assembly, which comprises a main body, a monitoring channel and a monitoring module, wherein the monitoring channel is arranged in the main body; the monitoring accessory is assembled in the monitoring channel; the main body is used for penetrating into a focus area of a human body during ablation operation, and the monitoring accessory is used for acquiring monitoring parameters reflecting the inactivation state of target tissue cells and/or the condition of normal tissue cells in the target tissue cells. According to the tumor ablation monitoring assembly, the tumor ablation device and the tumor ablation system, the monitoring parameters reflecting the inactivation state of the target tissue cells in the target tissue cells are obtained through the monitoring accessories, so that medical workers can conveniently judge the inactivation state of the tumor tissue cells in the target tissue cells in the ablation process in real time, and the problems that the normal tissues are damaged too much or the range of an expected ablation region is insufficient in the ablation operation process are avoided.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a tumor ablation monitoring assembly, a device and a system for tumor treatment.
Background
At present, the treatment means of tumors (such as brain tumors and the like) is mainly surgical operation, and is secondarily radiotherapy and chemotherapy. Wherein, the operation treatment takes long time, the blood loss is large, the open operation infection chance is large, and the treatment cost is high; part of patients are insensitive to radiotherapy, and radiotherapy has more side effects; most tumors are usually insensitive to chemotherapy and have significant systemic side effects. In order to solve the above problems, attempts have been made at home and abroad to overcome the side effects of the above three treatments by using ablation treatments such as microwave, radio frequency, laser, etc.
Ablation therapy refers to the effect of surgical excision by directly causing coagulation necrosis of tissues in a treatment area through high temperature or ultralow temperature. Among them, the main advantages of ablation therapy are: the operation is not needed, one-time or multiple-time conformal treatment can be adopted, the postoperative recovery is fast, the total treatment cost is low, and simultaneously, the immune system can be activated; the medicine has no radiation and chemical injury, does not cause the problem of insensitivity of tumors in radiotherapy and chemotherapy, can be repeatedly treated, and can also implement planned segmented treatment; the early-stage lesion can be treated radically, and the late-stage lesion can be treated palliatively, so that the tumor load is effectively reduced. Meanwhile, the traditional Chinese medicine composition can be matched with other treatment means such as radiotherapy, chemotherapy and the like, and does not conflict with other treatment methods.
Before ablation treatment, a simulation model body can be established by utilizing image three-dimensional reconstruction technologies such as CT (computed Tomography), MRI (magnetic resonance imaging) and the like, the process of tumor ablation is accurately simulated by utilizing the simulation model body by taking the same biological effect of a biological organism as a criterion, and medical workers can ensure that the treatment scheme is optimal accordingly. However, various errors cannot be avoided in the process of executing the treatment scheme, tumors grow in the human body, the cell inactivation state of tumor tissues in the planned treatment target area cannot be directly monitored in the treatment process, whether the target area tissues are completely inactivated or not cannot be judged in real time, and the problems that the damage of normal tissues is excessive or the range of an expected ablation area is insufficient are caused.
Disclosure of Invention
Based on this, it is necessary to provide a tumor ablation assembly, a device and a system which can improve the expected ablation effect during ablation and control the damage of normal tissues in order to solve the problems of excessive damage of normal tissues or insufficient expected ablation during the ablation of the conventional ablation devices.
A tumor ablation monitoring assembly comprises a main body, a monitoring channel and a monitoring device, wherein the monitoring channel is arranged in the main body; and a monitoring fitting fitted within the monitoring channel;
the main body is used for penetrating into a focus area of a human body during ablation operation, and the monitoring accessory is used for acquiring monitoring parameters of the tissue cell inactivation state of a reaction target area in tissue cells and/or the damage condition of normal tissue cells.
In one embodiment, the monitoring accessory comprises a substance detection identifier; the substance detection and identification piece is used for detecting and identifying substance components generated after tissue cells are ablated.
In one embodiment, the substance detection and identification component includes an optical transmission fiber and an analyzer, the main body is provided with a plurality of light holes communicated with the monitoring channel, one end of the optical transmission fiber extends into the monitoring channel, and the other end of the optical transmission fiber is in communication connection with the analyzer.
In one embodiment, the monitoring assembly further comprises a temperature probe for acquiring a current ablation temperature of target tissue cells, determining a duration of an ablation operation at the current ablation temperature and/or adjusting an energy output direction of the ablation needle.
In one embodiment, the tumor ablation monitoring assembly includes a driver drivingly connected to the monitoring accessory to control the depth of the monitoring accessory into the monitoring channel.
In one embodiment, one or more monitoring channels are formed in the main body;
when the monitoring channel is more than one, the monitoring accessory can enter different monitoring channels and the depth corresponding to the monitoring channels at the same or different time automatically under the drive of a manual or driving piece.
A tumor ablation device comprises a needle sleeve, an ablation needle and a monitoring accessory, wherein the ablation needle is nested in the needle sleeve; the monitoring accessory is assembled in the monitoring channel and used for acquiring monitoring parameters of the tissue cell inactivation state of the reaction target area in the tissue cells and/or the damage condition of normal tissue cells.
A tumor ablation system comprises a tumor ablation device and a controller in communication connection with the tumor ablation device, wherein the controller determines the inactivation state of target tissue cells and/or the damage condition of normal tissue cells according to monitoring parameters and controls working parameters of an ablation needle.
In one embodiment, when the monitoring assembly comprises a substance detection identifier, the substance detection identifier is used for acquiring substance components generated by tissue cells after ablation; the controller compares the identified substance components with preset biological effect data to determine the inactivation state of target tissue cells and/or the damage condition of normal tissue cells;
when the monitoring accessory comprises a temperature probe, the temperature probe is used for obtaining the current ablation temperature of the target tissue cells, and the controller is used for controlling the ablation operation to continue at the current ablation temperature for a preset time and/or adjusting the energy output direction of the ablation needle when the current ablation temperature of the target tissue cells reaches a preset temperature.
In one embodiment, the controller includes a treatment plan storage module, a state analysis module, and a control module;
the treatment plan storage module is used for receiving and storing ablation treatment plan parameters;
the state analysis module determines the inactivation state of target tissue cells and/or the damage condition of normal tissue cells according to the comparison result of the substance components identified by the substance detection identification piece and preset biological effect data; the state analysis module is used for comparing and analyzing the inactivation state of the target tissue cells and/or the damage condition of the normal tissue cells with the treatment plan to obtain the execution condition of the treatment plan and giving the next energy output scheme of the ablation treatment equipment in real time;
the control module is used for receiving the next energy output scheme given by the state analysis module and regulating and controlling the energy output of the ablation needle according to the energy output scheme.
According to the tumor ablation monitoring assembly, the tumor ablation device and the tumor ablation system, monitoring parameters reflecting the inactivation state of target tissue cells and/or the damage condition of normal tissue cells in the target tissue cells are obtained through the monitoring accessories, so that medical workers can conveniently judge the inactivation state of the tumor tissue cells and/or the damage condition of the normal tissue cells in the target tissue cells in real time in the ablation process, and excessive damage to normal tissues or insufficient ablation expectation in the ablation operation process is avoided.
Drawings
FIG. 1 is a schematic structural diagram of a tumor ablation device in accordance with an embodiment of the present invention;
FIG. 2 is a schematic structural view of a tumor ablation device in another embodiment of the present invention;
fig. 3 is a block diagram of a tumor ablation system in accordance with an embodiment of the present invention.
Detailed Description
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Before describing the ablation apparatus and system in detail, the related contents of the ablation treatment of the tumor will be described first, so as to better understand the technical solution of the ablation apparatus and system in the present invention.
The application of chemical or thermal methods directed at a focal solid tumor(s) under the guidance of imaging techniques (e.g., ultrasound, CT, MRI, cerebrovascular imaging, etc.) to eradicate or destroy the tumor tissue is known as ablative treatment of the tumor. Ablation therapy can be used for benign/malignant solid tumors of human organs (e.g., brain tumors, liver tumors, lung tumors, breast tumors), primary tumors, metastatic tumors, and the like.
Referring to fig. 1, in an embodiment of the present invention, a tumor ablation device 100 is inserted into a tumor lesion region through an interventional catheter, and the tumor ablation device 100 includes a needle sheath 10, an ablation needle 30 nested in the needle sheath 10, and a tumor ablation monitoring assembly (i.e., a body or a body and a monitoring fitting 53 mentioned below). The interventional catheter is used for providing a treatment channel, isolating a treatment instrument from a human body cavity and avoiding the treatment instrument from damaging other parts in the human body cavity. The ablation needle 30 is used to perform an ablation operation on the tumor tissue to treat the tumor tissue. The tumor ablation monitoring assembly and the ablation needle 30 are together deep into a focus area of a human body and used for obtaining monitoring parameters reflecting the inactivation state of target tissue cells and/or the damage condition of normal tissue cells in the target tissue cells, so that judgment basis is provided for medical workers to the inactivation state of the target tissue cells undergoing ablation operation, and damage to the normal tissue cells caused by incomplete ablation or excessive ablation of the target tissue cells due to improper operation is avoided. Preferably, the tumor ablation device 100 of the present application is applied to a solid tumor.
The tumor ablation monitoring assembly includes a main body (not shown) and a monitoring accessory 53. A monitoring channel 510 is arranged in the main body, the monitoring accessory 53 is assembled in the monitoring channel 510 and goes deep into a focus area of a human body when the main body is subjected to ablation operation, and the monitoring channel is used for acquiring monitoring parameters reflecting the inactivation state of target tissue cells in the target tissue cells.
In one embodiment, the needle sheath 10 and the main body of the tumor ablation monitoring assembly are separately arranged, that is, an assembly channel is reserved in the needle sheath 10 besides the ablation needle 30, the main body is detachably embedded into the needle sheath 10 through the assembly channel, and the monitoring accessory 53 is assembled in the monitoring channel 510 of the main body to go deep into a lesion area of a human body together with the ablation needle 30, so that the inactivation state of the target tissue cells is monitored while the target tissue cells are ablated.
In another embodiment, the needle sheath 10 is integrally provided with the main body of the tumor ablation monitoring assembly, i.e., the needle sheath 10 is identical to the main body of the tumor ablation monitoring assembly. The needle sheath 10 is provided with a monitoring channel 510 in advance except the ablation needle 30, and the monitoring accessory 53 is assembled in the monitoring channel 510 to go deep into the focus area of the human body together with the ablation needle 30, so that the inactivation state of the target tissue cells is monitored while the target tissue cells are ablated.
It should be noted that the "main body" described in the following embodiments may be a component separate from the needle hub 10 or a component integrally provided with the needle hub 10 (in this case, the same as the needle hub 10), and the following description is not particularly limited.
In one embodiment, the monitored parameter includes a current ablation temperature at which the target tissue cells are subjected to an ablation procedure. Specifically, the monitoring accessory 53 includes a temperature probe, the temperature probe is assembled in the monitoring channel 510, and the main body (when the main body and the needle cover 10 are integrally arranged, the main body and the needle cover 10 are both identical) or the main body and the needle cover 10 (when the main body and the needle cover 10 are separately arranged) are made of a heat conducting material, so that the temperature probe assembled in the monitoring channel 510 can detect the current ablation temperature when the ablation needle 30 performs an ablation operation on target tissue cells through the main body or the main body and the needle cover 10. At this time, by detecting the obtained current ablation temperature, the duration of the ablation operation can be determined and/or the energy output direction of the ablation needle 30 can be adjusted (for example, by rotating the laser to change the energy output direction of the ablation needle 30) to match the output of the appropriate ablation energy.
Referring to fig. 2, in another embodiment, the monitored parameter includes a composition of matter produced after ablation of cells in the target tissue. Specifically, the monitoring assembly 53 includes a substance detection identifier, which is assembled in the monitoring channel 510 for detecting and identifying the substance component generated after the ablation of the target tissue cells.
The applicant finds in research that the biological and chemical components of the tumor tissue and the normal tissue are different and the tissue structure is changed, the tissue components and the structure can be changed after the tumor tissue and the normal tissue are damaged by microwave or radio frequency ablation or laser ablation after ablation treatment, and the changed tissue components can be distinguished through the technologies of functional near infrared spectrum analysis, Raman scattering spectrum analysis, plasma analysis and the like. The detected and identified substance is a substance component generated after ablation and damage, and the substance can be an in-situ substance, an in-vivo residual substance, waste or gas extracted by negative pressure or conveyed out of a body by a machine, and the like. The mechanical transportation means directly taking out tumor cells, waste materials, or gases in the focal region by mechanical means, for example, directly taking out tumor cells, waste materials, or gases by mechanical parts deep into the focal region.
Therefore, in this embodiment, the substance detecting and identifying member includes an optical transmission fiber and an analyzer, the main body is provided with a plurality of light holes 512 communicated with the monitoring channel 510, one end of the optical transmission fiber extends into the monitoring channel 510, and the other end of the optical transmission fiber is in communication connection with the analyzer; the spectrum of the substance components generated after ablation and damage is obtained through the light-transmitting hole 512, the chemical composition and the relative content of the substance components are determined, and then the chemical composition and the relative content are compared with the biological effect, so that the inactivation state of the target tissue cells and/or the damage condition of the normal tissue cells are detected and identified in real time in the treatment process according to the comparison result, and the energy output of the ablation needle 30 in the next step is regulated and controlled according to the inactivation state of the target tissue cells and/or the damage condition of the normal tissue cells, thereby ensuring the accuracy of the whole treatment.
It is understood that in a specific application, the monitoring member 53 may be provided with only one or two of the temperature probe and the substance detection identifier, and correspondingly, the number of the monitoring channels 510 in the main body may be one or more, which is not limited herein. In addition, the technology used by the substance detection and identification part can be one or more of functional near infrared, Raman, plasma analysis and two-photon.
Further, the tumor ablation monitoring assembly includes a driver 55 that is positioned outside the body and drivingly connected to the monitoring subassembly 53 during an ablation procedure to control the depth of the monitoring subassembly 53 into the monitoring channel 510. Specifically, the driving member 55 may be, for example, a small-sized stepping motor, and the monitoring accessory 53 is driven to advance and retreat relative to the monitoring channel 510 by controlling the stepping motor, so as to monitor different lesion areas. It is understood that in other embodiments, the driving member 55 may have other driving structures, and is not limited herein. Even in other embodiments, drive member 55 may be eliminated and the depth of monitoring assembly 53 into monitoring channel 510 may be manually controlled, without limitation.
Furthermore, the main body is provided with scales corresponding to the depth of the monitoring fitting 53 entering and exiting the monitoring channel 510, so that the medical staff can conveniently and visually watch the scales.
Still further, one or more monitoring channels 510 are arranged in the main body; when there is more than one monitoring channel 510, the monitoring accessory 53 can be driven by a manual or driving device 55 to automatically select different monitoring channels 510 at the same or different time and depth corresponding to the monitoring channel 510.
Referring to fig. 3, the present application further provides a tumor ablation system 200, wherein the tumor ablation system 200 includes a tumor ablation device 100 and a controller 201 communicatively connected to the tumor ablation device 100. The controller 201 determines the inactivation state of the target tissue cells and/or the damage condition of the normal tissue cells according to the monitoring parameters, and controls the working parameters of the ablation needle 30. The operating parameters of the ablation needle 30 include ablation temperature, ablation time, etc.
In one embodiment, when the monitoring assembly 53 includes a temperature probe for obtaining the current ablation temperature of the target tissue cells, the controller 201 is configured to control the ablation operation to continue at the current ablation temperature for a predetermined time and/or adjust 30 the energy output direction of the ablation needle when the current ablation temperature of the target tissue cells reaches a predetermined temperature, so as to adaptively ensure the output of the proper ablation energy.
In another embodiment, when the monitoring assembly 53 includes a substance detection identifier, the substance detection identifier is assembled in the monitoring channel 510 for detecting and identifying the substance component generated after ablation of the target tissue cells. Specifically, the substance detection and identification part comprises an optical conduction fiber and an analyzer, a plurality of light holes 512 communicated with the monitoring channel 510 are formed in the main body, one end of the optical conduction fiber extends into the monitoring channel 510, and the other end of the optical conduction fiber is in communication connection with the analyzer; the spectrum of the material components generated after ablation damage is obtained through the light-transmitting hole 512, and the chemical composition and relative content of the material components are determined.
Correspondingly, the controller 201 includes a state analysis module 2012, and the state analysis module 2012 has pre-stored biological effect data of the plasma analysis technique. The state analysis module 2012 compares the data obtained by the substance detection identifier with the biological effect to determine the inactivation state of the target tissue cells and/or the damage condition of the normal tissue cells. Meanwhile, the state analysis module 2012 compares the inactivation state of the target tissue cells and/or the damage condition of the normal tissue cells with the treatment plan, and analyzes to obtain the execution condition of the treatment plan, and provides the energy output scheme of the ablation treatment device in real time.
The controller 201 includes a control module 2014 communicatively coupled to the ablation needle 30, and the control module 2014 is configured to receive the energy output scheme of the next step from the state analysis module 2012 and regulate the energy output of the ablation needle 30 according to the energy output scheme.
It is understood that in other embodiments, the monitoring assembly 53 may be provided with only one or both of a temperature probe and a substance detection identifier, and is not limited thereto.
The following describes the operation of the tumor ablation system 200 in detail, taking the tumor ablation system 200 as an example of the ablation treatment of the brain tumor:
acquiring patient imaging data (MRI/CT/cerebrovascular angiography and the like), introducing an image signal into a nerve navigation system, and carrying out image analysis and 3D reconstruction through the imaging (MRI/CT/cerebrovascular angiography and the like); through simulation technology +3D technology, a minimally invasive ablation treatment plan is made (needle insertion position, direction, depth are determined, treatment parameters such as power, time and the like are determined according to an ablation range), and the ablation treatment plan is stored in the treatment plan receiving module 2010.
Secondly, the tumor ablation system 200 is started, after disinfection and anesthesia, the nerve navigation system is adopted for guiding, positioning, marking, drilling and breaking bone at the external projection position of the tumor center skull, a puncture needle is used for puncturing the meninges, and the guide puncture needle is inserted to a preset diagnosis and treatment target position in the skull under the guidance of the nerve navigation instrument for subsequent ablation operation.
During the ablation process, the substance detection and identification part detects the spectrum of the substance components generated after ablation damage, determines the chemical composition and the relative content of the substance components, and transmits the chemical composition and the relative content to the state analysis module 202; the state analysis module 2012 compares the data obtained by the substance detection identifier with the biological effect to determine the inactivation state of the target tissue cells and/or the damage condition of the normal tissue cells; comparing and analyzing the inactivation state of the target tissue cells and/or the damage condition of the normal tissue cells with the treatment plan to obtain the execution condition of the treatment plan, and providing a next energy output scheme of the ablation treatment equipment to the control module 2014 in real time; the control module 2014 receives the next energy output scheme given by the state analysis module 2012 and regulates the energy output of the ablation needle 30 according to the energy output scheme to ensure accurate execution of the treatment plan.
According to the tumor ablation monitoring assembly, the tumor ablation device 100 and the tumor ablation system 200, monitoring parameters reflecting the inactivation state of target tissue cells and/or the damage condition of normal tissue cells in the target tissue cells are obtained through the monitoring accessories 53, so that medical workers can conveniently judge the inactivation state of the tumor tissue cells and/or the damage condition of the normal tissue cells in the target tissue cells in the ablation process in real time, and excessive damage to normal tissues or insufficient ablation expectation in the ablation operation process is avoided.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A tumor ablation monitoring assembly, comprising:
a main body, in which a monitoring channel is arranged; and
a monitoring fitting fitted within the monitoring channel;
the main body is used for penetrating into a focus area of a human body during ablation operation, and the monitoring accessory is used for acquiring monitoring parameters of the inactivation state of reaction tissue cells and/or the damage condition of normal tissue cells in the tissue cells.
2. The tumor ablation monitoring assembly of claim 1, wherein the monitoring accessory includes a substance detection identifier; the substance detection and identification piece is used for detecting and identifying substance components generated after tissue cells are ablated.
3. The tumor ablation monitoring assembly of claim 2, wherein the substance detecting and identifying member comprises an optical fiber and an analyzer, the main body defines a plurality of light holes communicating with the monitoring channel, one end of the optical fiber extends into the monitoring channel, and the other end of the optical fiber is in communication with the analyzer.
4. The tumor ablation monitoring assembly of claim 2, wherein the monitoring assembly further comprises a temperature probe for obtaining a current ablation temperature of target tissue cells to determine a duration of an ablation operation at the current ablation temperature and/or to adjust the ablation needle energy output direction.
5. The tumor ablation monitoring assembly of claim 1, comprising a driver drivingly connected to the monitoring accessory to control the depth of the monitoring accessory into the monitoring channel.
6. The tumor ablation monitoring assembly of claim 5, wherein one or more of the monitoring channels are formed in the body;
when the monitoring channel is more than one, the monitoring accessory can enter different monitoring channels and the depth corresponding to the monitoring channels at the same or different time automatically under the drive of a manual or driving piece.
7. A tumor ablation device, which is characterized in that the tumor ablation device comprises a needle sleeve, an ablation needle nested in the needle sleeve and a tumor ablation monitoring assembly according to any one of claims 1 to 6, wherein a monitoring channel is formed in the needle sleeve; the monitoring accessory is assembled in the monitoring channel and used for acquiring monitoring parameters of the inactivation state of reaction histiocytes and/or the damage condition of normal histiocytes in target tissue cells.
8. A tumor ablation system comprising the tumor ablation device of claim 7 and a controller communicatively connected to the tumor ablation device, wherein the controller determines the inactivation status of the target tissue cells and/or the damage status of the normal tissue cells according to the monitored parameters, and controls the operating parameters of the ablation needle.
9. The system of claim 7, wherein the monitoring assembly includes a substance detection identifier for obtaining a substance component produced by tissue cells after ablation; the controller compares the identified substance components with preset biological effect data to determine the inactivation state of target tissue cells and/or the damage condition of normal tissue cells;
when the monitoring accessory comprises a temperature probe, the temperature probe is used for obtaining the current ablation temperature of the target tissue cells, and the controller is used for controlling the ablation operation to continue at the current ablation temperature for a preset time and/or adjusting the energy output direction of the ablation needle when the current ablation temperature of the target tissue cells reaches a preset temperature.
10. The tumor ablation system of claim 9, wherein the controller comprises a treatment plan storage module, a state analysis module, and a control module;
the treatment plan storage module is used for receiving and storing ablation treatment plan parameters;
the state analysis module determines the inactivation state of target tissue cells and/or the damage condition of normal tissue cells according to the comparison result of the substance components identified by the substance detection identification piece and preset biological effect data; the state analysis module is used for comparing and analyzing the inactivation state of the target tissue cells and/or the damage condition of the normal tissue cells with the treatment plan to obtain the execution condition of the treatment plan and giving the next energy output scheme of the ablation treatment equipment in real time;
the control module is used for receiving the next energy output scheme given by the state analysis module and regulating and controlling the energy output of the ablation needle according to the energy output scheme.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910203845.3A CN111714202A (en) | 2019-03-18 | 2019-03-18 | Tumor ablation monitoring assembly, device and system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910203845.3A CN111714202A (en) | 2019-03-18 | 2019-03-18 | Tumor ablation monitoring assembly, device and system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111714202A true CN111714202A (en) | 2020-09-29 |
Family
ID=72562278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910203845.3A Pending CN111714202A (en) | 2019-03-18 | 2019-03-18 | Tumor ablation monitoring assembly, device and system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111714202A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112971977A (en) * | 2021-02-05 | 2021-06-18 | 南京航空航天大学 | Accurate treatment of tumour microwave ablation and aassessment instrument |
| CN113842210A (en) * | 2021-08-02 | 2021-12-28 | 应葵 | Vertebral tumor microwave ablation operation simulation method and device |
| CN113871017A (en) * | 2021-09-30 | 2021-12-31 | 杭州佳量医疗科技有限公司 | Method and device for estimating corresponding information of ablation consumables and focus |
| CN118000887A (en) * | 2024-04-10 | 2024-05-10 | 杭州睿笛生物科技有限公司 | Needle advancing and retreating method, device and system for thermosetting hemostatic ablation integrated needle |
| CN113842210B (en) * | 2021-08-02 | 2024-10-22 | 应葵 | Vertebrae tumor microwave ablation operation simulation method and device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050119548A1 (en) * | 2002-07-05 | 2005-06-02 | Vanderbilt University | Method and apparatus for optical spectroscopic detection of cell and tissue death |
| CN101563018A (en) * | 2006-04-27 | 2009-10-21 | 劳伦斯利弗莫尔国家安全有限责任公司 | Fiber optic evaluation of tissue modification |
| CN102781357A (en) * | 2010-02-26 | 2012-11-14 | 皇家飞利浦电子股份有限公司 | Interventional ablation device with tissue discriminating capability |
| US20140094792A1 (en) * | 2012-10-02 | 2014-04-03 | Covidien Lp | Heat-sensitive optical probes |
| CN210019632U (en) * | 2019-03-18 | 2020-02-07 | 刘珈 | Tumor ablation monitoring assembly and device |
-
2019
- 2019-03-18 CN CN201910203845.3A patent/CN111714202A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050119548A1 (en) * | 2002-07-05 | 2005-06-02 | Vanderbilt University | Method and apparatus for optical spectroscopic detection of cell and tissue death |
| CN101563018A (en) * | 2006-04-27 | 2009-10-21 | 劳伦斯利弗莫尔国家安全有限责任公司 | Fiber optic evaluation of tissue modification |
| CN102781357A (en) * | 2010-02-26 | 2012-11-14 | 皇家飞利浦电子股份有限公司 | Interventional ablation device with tissue discriminating capability |
| US20140094792A1 (en) * | 2012-10-02 | 2014-04-03 | Covidien Lp | Heat-sensitive optical probes |
| CN210019632U (en) * | 2019-03-18 | 2020-02-07 | 刘珈 | Tumor ablation monitoring assembly and device |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112971977A (en) * | 2021-02-05 | 2021-06-18 | 南京航空航天大学 | Accurate treatment of tumour microwave ablation and aassessment instrument |
| CN113842210A (en) * | 2021-08-02 | 2021-12-28 | 应葵 | Vertebral tumor microwave ablation operation simulation method and device |
| CN113842210B (en) * | 2021-08-02 | 2024-10-22 | 应葵 | Vertebrae tumor microwave ablation operation simulation method and device |
| CN113871017A (en) * | 2021-09-30 | 2021-12-31 | 杭州佳量医疗科技有限公司 | Method and device for estimating corresponding information of ablation consumables and focus |
| CN118000887A (en) * | 2024-04-10 | 2024-05-10 | 杭州睿笛生物科技有限公司 | Needle advancing and retreating method, device and system for thermosetting hemostatic ablation integrated needle |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10092367B2 (en) | Image-guided therapy of a tissue | |
| US9700342B2 (en) | Image-guided therapy of a tissue | |
| US8942781B2 (en) | Medical system comprising a percutaneous probe | |
| CN111714202A (en) | Tumor ablation monitoring assembly, device and system | |
| US10675113B2 (en) | Automated therapy of a three-dimensional tissue region | |
| CN215691052U (en) | Automatic implantation system of deep brain electrode based on image and electrophysiological real-time positioning | |
| US11191446B2 (en) | Devices, systems and methods for tissue analysis, locaton determination and tissue ablation | |
| US20210393332A1 (en) | Methods and devices for navigating a tissue resection device | |
| EP3261550A1 (en) | Apparatus and method for positioning medical instruments assisted by indirect visualization | |
| CN210019632U (en) | Tumor ablation monitoring assembly and device | |
| WO2005094692A1 (en) | System and method for tissue sampling and therapeutic treatment | |
| WO2016135596A1 (en) | Indirect visualization-assisted apparatus and method for positioning medical instruments | |
| EP4146102A1 (en) | Tissue resection control systems and methods | |
| US20230108832A1 (en) | Device for tissue treatment and method for electrode positioning | |
| WO2024076360A1 (en) | Orthopedic bone awl with optoelectronic feedback |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |