CN111686673A - Device and improved technology for preparing acetyl captopril - Google Patents
Device and improved technology for preparing acetyl captopril Download PDFInfo
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- CN111686673A CN111686673A CN202010678163.0A CN202010678163A CN111686673A CN 111686673 A CN111686673 A CN 111686673A CN 202010678163 A CN202010678163 A CN 202010678163A CN 111686673 A CN111686673 A CN 111686673A
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/10—Particle separators, e.g. dust precipitators, using filter plates, sheets or pads having plane surfaces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/30—Particle separators, e.g. dust precipitators, using loose filtering material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/56—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition
- B01D46/62—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with multiple filtering elements, characterised by their mutual disposition connected in series
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/88—Replacing filter elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0066—Stirrers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
- B01J19/0073—Sealings
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B15/00—Preventing escape of dirt or fumes from the area where they are produced; Collecting or removing dirt or fumes from that area
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/141—Feedstock
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Abstract
The invention discloses a device for preparing acetyl captopril and an improved process, wherein a reaction mechanism comprises a reaction tank, a tank cover, a discharge pipe, a sealing cover and three support columns, a stirring mechanism is arranged between the tank cover and the reaction tank, the stirring mechanism comprises a support frame, a motor, a rotary table, a transmission shaft, a driving wheel, a plurality of driven wheels, a plurality of rotating shafts and a plurality of stirring blades, a feeding pipe is arranged at the top of the tank cover, and the top end of the feeding pipe is in threaded connection with the protective cover. The vacuum pump can pump out air in the reaction tank and the tank cover through the second connecting pipe, the filter chamber and the first connecting pipe, so that the content of air between the reaction tank and the tank cover is reduced, the content of oxygen between the reaction tank and the tank cover is reduced, and the condition that the property of the acetocaptopril is reduced due to oxidation reaction caused by contact of raw materials and oxygen in the air in the reaction process is reduced.
Description
Technical Field
The invention relates to the technical field of medicine processing, in particular to a device and an improved process for preparing acetyl captopril.
Background
Acetocaptopril is an angiotensin converting enzyme inhibitor and is applied to treating hypertension and certain types of congestive heart failure, and as a first ACEI drug, captopril is considered as a breakthrough in drug therapy due to a new action mechanism and a revolutionary development process.
The preparation method of the acetocaptopril has the advantages that a reaction device is needed to provide a reaction site for raw materials of the acetocaptopril in the preparation process, and the raw materials are in contact with oxygen in the air to generate an oxidation reaction in the reaction process of the existing reaction device, so that the medicinal property of the acetocaptopril is reduced. Therefore, we improve the technology and propose a device and an improved process for preparing the acetyl captopril.
Disclosure of Invention
In order to solve the technical problems, the invention provides the following technical scheme:
the invention relates to a device and an improved process for preparing acetyl captopril, which comprises a reaction mechanism, wherein the reaction mechanism consists of a reaction tank, a tank cover, a discharge pipe, a sealing cover and three support columns, a stirring mechanism is arranged between the tank cover and the reaction tank, the stirring mechanism consists of a support frame, a motor, a rotary disc, a transmission shaft, a driving wheel, a plurality of driven wheels, a plurality of rotating shafts and a plurality of stirring blades, a feeding pipe is arranged at the top of the tank cover, and the top end of the feeding pipe is in threaded connection with a protective cover;
the left surface of retort is provided with repressing mechanism, repressing mechanism comprises intake pipe, support cover, support ring, push rod, filter screen and first valve, the right flank of retort is provided with vacuum mechanism, vacuum mechanism comprises filter chamber, first connecting pipe, second valve, filter pulp, shutoff lid, second connecting pipe and vacuum pump.
As a preferable technical scheme of the invention, the tank cover is installed at the top of the reaction tank through a plurality of bolts, a sealing gasket is arranged between the tank cover and the reaction tank, the discharge pipe is fixedly communicated with the middle part of the bottom end of the reaction tank, the sealing cover is in threaded connection with the bottom end of the discharge pipe, the three support columns are all fixedly installed at the bottom of the reaction tank, and the rotary table is connected with the inner wall of the tank cover through a sealing bearing.
As a preferred technical scheme of the present invention, the support frame is fixedly mounted at the top of the tank cover and located above the turntable, the motor is fixedly mounted at the top of the support frame, an output shaft of the motor penetrates through the top wall of the support frame and is fixedly connected with the top end of the transmission shaft, the bottom end of the transmission shaft is fixedly connected with the middle portion of the top end of the turntable, and the driving wheel is fixedly sleeved on the outer surface of the transmission shaft.
As a preferred technical scheme of the invention, the outer surfaces of the rotating shafts are connected with the inner wall of the rotary table through sealed bearings, the top ends of the rotating shafts extend to the upper part of the rotary table and are respectively fixedly sleeved with the driven wheels, the driven wheels are respectively meshed with the driving wheel, and the stirring blades are respectively arranged on the outer surfaces of the rotating shafts.
As a preferable technical scheme of the invention, one end of the air inlet pipe is fixedly communicated with the top of the left side surface of the reaction tank, the other end of the air inlet pipe is fixedly communicated with the support cover, the outer surface of the support ring is in threaded connection with the inner wall of the support cover, the push rod is fixedly installed on the front surface of the support ring, the filter screen is arranged in the middle of the support ring, and the first valve is arranged in the middle of the air inlet pipe.
As a preferable technical solution of the present invention, the filter chamber is fixedly installed on a right side surface of the reaction tank, one end of the first connection pipe is fixedly communicated with a top of the filter chamber, the other end of the first connection pipe penetrates through the reaction tank and extends to an inside of the reaction tank, and the second valve is disposed on the first connection pipe and located between the reaction tank and the filter chamber.
As a preferred technical scheme of the present invention, the filter cotton is placed inside the filtering chamber, the blocking cover is screwed at the bottom of the filtering chamber, the vacuum pump is fixedly installed on one surface of the filtering chamber away from the reaction tank, one end of the second connecting pipe is connected with the vacuum pump, and the other end of the second connecting pipe is connected with the filtering chamber.
As a preferable technical scheme of the invention, the method comprises the following steps:
A. adding the raw materials, namely unscrewing a protective cover at the top of a feeding pipe, pouring the raw materials for producing the acetocaptopril into a reaction tank from the feeding pipe, and after the raw materials are poured, re-screwing the protective cover to the top end of the feeding pipe;
B. the second valve is opened and the first valve is closed after air is pumped out, then the vacuum pump is started, the vacuum pump pumps out the air in the reaction tank and the tank cover through the second connecting pipe, the filter chamber and the first connecting pipe, and the second valve is closed and the vacuum pump is stopped after the air is pumped out;
C. stirring reaction, starting a motor, driving a transmission shaft, a turntable and a driving wheel to rotate through the motor, and driving a plurality of rotating shafts to rotate through the mutual matching of the driving wheel and a plurality of driven wheels, so that the stirring blades revolve around the driving wheel as a center and rotate around the rotating shafts as the center to stir the materials in the reaction tank, and the materials are mixed and reacted to obtain the acetylcatapril;
D. discharging the materials, opening a first valve after the reaction is finished to balance the air pressure in the reaction tank with the outside, and then rotating a sealing cover to separate the sealing cover from a discharging pipe, so that the acetyl captopril in the reaction tank is discharged;
E. cleaning the filter screen, holding the push rod, rotating the support ring through the push rod to separate the support ring from the support cover, cleaning the filter screen by using the conventional equipment, and screwing the support ring into the support cover after cleaning;
F. the clearance of filter pulp, it makes plugging cover and filter chamber separation to rotate the plugging cover, and the filter pulp is taken out from the filter chamber to the pulling filter pulp downwards, then gets off the material clearance on the filter pulp, then will clear up the filter pulp of accomplishing and put back in the filter chamber again with the plugging cover screw on the filter chamber can.
The invention has the beneficial effects that:
1. according to the device and the improved process for preparing the acetyl captopril, the vacuum pump can pump out air in the reaction tank and the tank cover through the second connecting pipe, the filter chamber and the first connecting pipe, so that the content of the air between the reaction tank and the tank cover is reduced, the content of oxygen between the reaction tank and the tank cover is reduced, and the condition that the drug property of the acetyl captopril is reduced due to oxidation reaction caused by contact of raw materials and the oxygen in the air in the reaction process is reduced;
2. according to the device and the improved process for preparing the acetyl captopril, the opening of one end, positioned inside the reaction tank, of the first connecting pipe faces upwards, so that the situation that powder raw materials enter the first connecting pipe can be reduced, air entering the filtering chamber can be filtered through the filter cotton, and therefore trace powder raw materials carried in the air are filtered, on one hand, the waste of resources can be reduced, and on the other hand, the influence of the powder entering the vacuum pump on the service life of the vacuum pump can be reduced;
3. according to the device and the improved process for preparing the acetyl captopril, after the first valve is opened, external air enters the reaction tank through the air inlet pipe, so that the external air pressure in the reaction tank is balanced, the air entering the air inlet pipe can be filtered through the filter screen, the condition that dust in the air enters the reaction tank is reduced, the support ring can be separated from the support cover by rotating the support ring, a user can clean the filter screen conveniently, and the practicability of the device is improved;
4. according to the device and the improved process for preparing the acetocaptopril, the transmission shaft, the rotary table and the driving wheel are driven to rotate by the motor, and the driving wheel and the driven wheels are matched with each other to drive the rotating shafts to rotate, so that the stirring blades revolve around the driving wheel as a center and rotate around the rotating shafts as the center to stir materials in the reaction tank, and the uniformity of material mixing can be improved;
5. according to the device and the improved process for preparing the acetyl captopril, the preparation device is improved, so that the condition that the raw materials are in contact with oxygen in the air to generate oxidation reaction in the reaction process is greatly reduced, the condition that the medicine property of the acetyl captopril is reduced, and the production process of the acetyl captopril is effectively improved.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
FIG. 1 is a schematic diagram of the apparatus and improved process for the preparation of acetylcaptopril according to the present invention;
FIG. 2 is a schematic cross-sectional view of a reaction tank of an apparatus and an improved process for preparing acetylcaptopril according to the present invention;
FIG. 3 is a schematic view of the structure of the driving wheel and the driven wheel of the apparatus and the improved process for preparing acetylcaptopril of the present invention;
FIG. 4 is a schematic structural view of a vacuum mechanism of an apparatus and a modified process for preparing acetylcaptopril according to the present invention;
FIG. 5 is a schematic structural view of a rotating shaft and a stirring blade of the apparatus for preparing acetyl captopril and the improved process of the present invention;
FIG. 6 is a schematic left side view of a support ring of an apparatus and modified process for the preparation of acetyl captopril according to the present invention;
FIG. 7 is an enlarged schematic view of the apparatus and improved process for the preparation of acetylcaptopril of the present invention at A in FIG. 2.
In the figure: 1. a reaction tank; 2. a can lid; 3. a discharge pipe; 4. a sealing cover; 5. a support pillar; 6. a support frame; 7. a motor; 8. a turntable; 9. a drive shaft; 10. a driving wheel; 11. a driven wheel; 12. a rotating shaft; 13. a stirring blade; 14. a feed tube; 15. an air inlet pipe; 16. a support housing; 17. a support ring; 18. a push rod; 19. filtering with a screen; 20. a first valve; 21. a filtering chamber; 22. a first connecting pipe; 23. a second valve; 24. filtering cotton; 25. a blocking cover; 26. a second connecting pipe; 27. a vacuum pump.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
Example (b): as shown in fig. 1-7, the device for preparing acetylcatapril and the improved process thereof of the invention comprise a reaction mechanism, wherein the reaction mechanism comprises a reaction tank 1, a tank cover 2, a discharge pipe 3, a sealing cover 4 and supporting columns 5, the number of the supporting columns 5 is three, a stirring mechanism is arranged between the tank cover 2 and the reaction tank 1, the stirring mechanism comprises a supporting frame 6, a motor 7, a rotating disk 8, a transmission shaft 9, a driving wheel 10, a plurality of driven wheels 11, a plurality of rotating shafts 12 and a plurality of stirring blades 13, a feeding pipe 14 is arranged at the top of the tank cover 2, and the top end of the feeding pipe 14 is in threaded connection with a protective cover;
the left side surface of the reaction tank 1 is provided with a repressing mechanism, the repressing mechanism consists of an air inlet pipe 15, a support cover 16, a support ring 17, a push rod 18, a filter screen 19 and a first valve 20, the right side surface of the reaction tank 1 is provided with a vacuum mechanism, and the vacuum mechanism consists of a filter chamber 21, a first connecting pipe 22, a second valve 23, filter cotton 24, a blocking cover 25, a second connecting pipe 26 and a vacuum pump 27.
Wherein, cover 2 is installed at the top of retort 1 through a plurality of bolt, be provided with sealed the pad between cover 2 and the retort 1, arrange the middle part of row's material pipe 3 fixed intercommunication in retort 1 bottom, 4 threaded connection of sealed lid are in the bottom of arranging material pipe 3, the equal fixed mounting in the bottom of retort 1 of three support column 5, carousel 8 links to each other through sealed bearing and the inner wall of cover 2, through setting up, can play the guard action to the bottom of arranging material pipe 3 through setting up sealed lid 4, can support the bottom of retort 1 through setting up support column 5.
Wherein, support frame 6 fixed mounting just is located the top of carousel 8 at the top of cover 2, motor 7 fixed mounting is at the top of support frame 6, the output shaft of motor 7 run through the roof of support frame 6 and with the top fixed connection on transmission shaft 9, the bottom of transmission shaft 9 and the middle part fixed connection on carousel 8 top, the fixed cover of action wheel 10 is established at the surface of transmission shaft 9, the usable model of motor 7 is Y100L2-4 type motor, can support motor 7 through setting up support frame 6, can drive transmission shaft 9 through motor 7, action wheel 10 and carousel 8 rotate, and the sealed bearing that sets up between carousel 8 and the cover 2 inner wall can guarantee the leakproofness between carousel 8 and cover 2 when carousel 8 pivoted.
Wherein, the surface of a plurality of pivot 12 all links to each other through sealed bearing and carousel 8's inner wall, the top of a plurality of pivot 12 all extends to carousel 8's top and respectively with a plurality of from driving wheel 11 fixed cup joint, a plurality of from driving wheel 11 all with the meshing of action wheel 10, a plurality of stirring vane 13 sets up respectively on the surface of a plurality of pivot 12, drive transmission shaft 9 through motor 7, carousel 8 and action wheel 10 rotate, can drive a plurality of pivot 12 through action wheel 10 and a plurality of from the mutually supporting of driving wheel 11 and rotate, thereby make stirring vane 13 use pivot 12 to center rotation and stir the material of retort 1 inside again when revolving around action wheel 10 as the center, thereby can improve the homogeneity of material mixture.
Wherein, the fixed intercommunication in top of the one end of intake pipe 15 and retort 1 left surface, the other end and the fixed intercommunication of support cover 16 of intake pipe 15, the surface of support ring 17 and the inner wall threaded connection of support cover 16, push rod 18 fixed mounting is in the front of support ring 17, filter screen 19 sets up the middle part at support ring 17, first valve 20 sets up the middle part at intake pipe 15, open outside air in 20 back of first valve and get into retort 1 by intake pipe 15, make retort 1 inside and outside atmospheric pressure balanced, can filter the air that gets into in intake pipe 15 through filter screen 19, thereby reduce the condition in the air dust gets into retort 1, it can make support ring 17 and support cover 16 separation to rotate support ring 17, thereby the person of facilitating the use washs filter screen 19, the device's practicality has been improved.
Wherein, filter chamber 21 fixed mounting is in the right flank of retort 1, and the one end of first connecting pipe 22 and the fixed intercommunication in top of filter chamber 21, the other end of first connecting pipe 22 run through retort 1 and extend to the inside of retort 1, and second valve 23 sets up on first connecting pipe 22 and is located between retort 1 and the filter chamber 21.
Wherein, filter pulp 24 is placed in the inside of filter chamber 21, blocking cover 25 threaded connection is in the bottom of filter chamber 21, vacuum pump 27 fixed mounting is on the one side of filter chamber 21 keeping away from retort 1, the one end of second connecting pipe 26 links to each other with vacuum pump 27, the other end of second connecting pipe 26 links to each other with filter chamber 21, the model that vacuum pump 27 is applicable is 2XZ-2B type vacuum pump, vacuum pump 27 passes through second connecting pipe 26, filter chamber 21 and first connecting pipe 22 can take out the air in retort 1 and the cover 2, thereby reduce the content of air between retort 1 and the cover 2, can reduce the oxygen content between retort 1 and the cover 2, thereby reduce the oxygen contact of raw materials in the reaction process and the air and take place oxidation reaction, lead to the circumstances that the medicine property of acetyl captopril descends.
The method comprises the following steps:
A. adding the raw materials, namely unscrewing a protective cover at the top of the feeding pipe 14, pouring the raw materials for producing the acetocaptopril into the reaction tank 1 from the feeding pipe 14, and after the pouring of the raw materials is finished, re-screwing the protective cover to the top end of the feeding pipe 14;
B. air is pumped out, the second valve 23 is opened and the first valve 20 is closed, then the vacuum pump 27 is started, the vacuum pump 27 pumps out the air in the reaction tank 1 and the tank cover 2 through the second connecting pipe 26, the filter chamber 21 and the first connecting pipe 22, and after the air is pumped out, the second valve 23 is closed and the vacuum pump 27 is stopped;
C. stirring reaction, starting a motor 7, driving a transmission shaft 9, a turntable 8 and a driving wheel 10 to rotate through the motor 7, and driving a plurality of rotating shafts 12 to rotate through the mutual matching of the driving wheel 10 and a plurality of driven wheels 11, so that stirring blades 13 revolve around the driving wheel 10 as a center and rotate around the rotating shafts 12 as the center to stir the materials in the reaction tank 1, and the materials are subjected to mixing reaction to obtain the acetocaptopril;
D. discharging the materials, opening the first valve 20 after the reaction is finished to balance the air pressure in the reaction tank 1 with the outside, and then rotating the sealing cover 4 to separate the sealing cover 4 from the discharging pipe 3, so that the acetyl captopril in the reaction tank 1 is discharged;
E. cleaning the filter screen 19, holding the push rod 18 and rotating the support ring 17 through the push rod 18 to separate the support ring 17 from the support cover 16, then cleaning the filter screen 19 by using the existing equipment, and screwing the support ring 17 into the support cover 16 after cleaning;
F. cleaning the filter cotton 24, rotating the plugging cover 25 to separate the plugging cover 25 from the filtering chamber 21, pulling the filter cotton 24 downwards to take the filter cotton 24 out of the filtering chamber 21, then cleaning the material on the filter cotton 24, then putting the cleaned filter cotton 24 back into the filtering chamber 21, and screwing the plugging cover 25 onto the filtering chamber 21.
When the device works, firstly, the protective cover at the top of the feeding pipe 14 is unscrewed, raw materials for producing the acetyl captopril are poured into the reaction tank 1 from the feeding pipe 14, after the raw materials are poured, the protective cover is screwed to the top end of the feeding pipe 14 again, the second valve 23 is opened, the first valve 20 is closed, then the vacuum pump 27 is started, the vacuum pump 27 pumps air in the reaction tank 1 and the tank cover 2 through the second connecting pipe 26, the filter chamber 21 and the first connecting pipe 22, the second valve 23 is closed after the pumping is finished, the vacuum pump 27 is stopped, then the motor 7 is started, the transmission shaft 9, the rotary disc 8 and the driving wheel 10 are driven to rotate through the motor 7, the plurality of rotating shafts 12 can be driven to rotate through the mutual matching of the driving wheel 10 and the plurality of driven wheels 11, so that the stirring blades 13 revolve around the driving wheel 10 and rotate around the rotating shafts 12 and stir materials in the reaction tank 1, so as to mix and react the materials to obtain the acetyl captopril, after the reaction is finished, the first valve 20 is opened to balance the air pressure in the reaction tank 1 with the outside, then the sealing cover 4 is rotated to separate the sealing cover 4 from the discharge pipe 3, so as to discharge the acetyl captopril in the reaction tank 1, the push rod 18 is held and the support ring 17 is rotated through the push rod 18, so that the support ring 17 is separated from the support cover 16, then the filter screen 19 is cleaned by using the existing equipment, after the cleaning is finished, the support ring 17 is screwed into the support cover 16, the blocking cover 25 is rotated to separate the blocking cover 25 from the filter chamber 21, the filter cotton 24 is pulled downwards to take out the filter cotton 24 from the filter chamber 21, then the materials on the filter cotton 24 are cleaned, then the cleaned filter cotton 24 is put back into the filter chamber 21, and the blocking cover 25 is screwed onto the filter chamber 21.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (8)
1. The device for preparing the acetocaptopril is characterized by comprising a reaction mechanism, wherein the reaction mechanism consists of a reaction tank (1), a tank cover (2), a discharge pipe (3), a sealing cover (4) and support columns (5), the number of the support columns (5) is three, a stirring mechanism is arranged between the tank cover (2) and the reaction tank (1), the stirring mechanism consists of a support frame (6), a motor (7), a rotary disc (8), a transmission shaft (9), a driving wheel (10), a plurality of driven wheels (11), a plurality of rotating shafts (12) and a plurality of stirring blades (13), a feeding pipe (14) is arranged at the top of the tank cover (2), and a protective cover is connected to the top end of the feeding pipe (14) in a threaded manner;
the left surface of retort (1) is provided with repressing mechanism, repressing mechanism comprises intake pipe (15), support cover (16), support ring (17), push rod (18), filter screen (19) and first valve (20), the right surface of retort (1) is provided with vacuum mechanism, vacuum mechanism comprises filter chamber (21), first connecting pipe (22), second valve (23), filter pulp (24), shutoff lid (25), second connecting pipe (26) and vacuum pump (27).
2. The device of claim 1, characterized in that, cover (2) is installed at the top of retort (1) through a plurality of bolt, be provided with sealed the pad between cover (2) and retort (1), arrange the fixed middle part that communicates in retort (1) bottom of row material pipe (3), sealed lid (4) threaded connection is in the bottom of arranging material pipe (3), three equal fixed mounting in the bottom of retort (1) of support column (5), carousel (8) links to each other through sealed bearing and the inner wall of cover (2).
3. The device for preparing the acetylcardopril according to claim 1, wherein the supporting frame (6) is fixedly installed at the top of the tank cover (2) and located above the rotating disc (8), the motor (7) is fixedly installed at the top of the supporting frame (6), the output shaft of the motor (7) penetrates through the top wall of the supporting frame (6) and is fixedly connected with the top end of the transmission shaft (9), the bottom end of the transmission shaft (9) is fixedly connected with the middle part of the top end of the rotating disc (8), and the driving wheel (10) is fixedly sleeved on the outer surface of the transmission shaft (9).
4. The device for preparing the acetylcardopril according to claim 1, wherein the outer surfaces of the rotating shafts (12) are connected with the inner wall of the rotating disc (8) through sealed bearings, the top ends of the rotating shafts (12) extend to the upper side of the rotating disc (8) and are fixedly sleeved with the driven wheels (11), the driven wheels (11) are meshed with the driving wheel (10), and the stirring blades (13) are arranged on the outer surfaces of the rotating shafts (12) respectively.
5. The device for preparing the acetylcatapril according to claim 1, wherein one end of the air inlet pipe (15) is fixedly communicated with the top of the left side surface of the reaction tank (1), the other end of the air inlet pipe (15) is fixedly communicated with the support cover (16), the outer surface of the support ring (17) is in threaded connection with the inner wall of the support cover (16), the push rod (18) is fixedly installed on the front surface of the support ring (17), the filter screen (19) is arranged in the middle of the support ring (17), and the first valve (20) is arranged in the middle of the air inlet pipe (15).
6. The apparatus for preparing acetylcatapril according to claim 1, wherein the filtering chamber (21) is fixedly installed at the right side of the reaction tank (1), one end of the first connecting pipe (22) is fixedly communicated with the top of the filtering chamber (21), the other end of the first connecting pipe (22) penetrates through the reaction tank (1) and extends to the inside of the reaction tank (1), and the second valve (23) is disposed on the first connecting pipe (22) and located between the reaction tank (1) and the filtering chamber (21).
7. The apparatus for preparing acetylcatapril according to claim 1, wherein the filter cotton (24) is placed inside the filtering chamber (21), the blocking cover (25) is screwed on the bottom of the filtering chamber (21), the vacuum pump (27) is fixedly installed on the surface of the filtering chamber (21) far away from the reaction tank (1), one end of the second connecting pipe (26) is connected with the vacuum pump (27), and the other end of the second connecting pipe (26) is connected with the filtering chamber (21).
8. An improved process for the preparation of acetylcaptopril according to claim 1, comprising the steps of:
A. adding raw materials, namely unscrewing a protective cover at the top of a feeding pipe (14), pouring the raw materials for producing the acetocaptopril into a reaction tank (1) from the feeding pipe (14), and after the raw materials are poured, re-screwing the protective cover to the top end of the feeding pipe (14);
B. air is pumped out, the second valve (23) is opened, the first valve (20) is closed, then a vacuum pump (27) is started, the vacuum pump (27) pumps out air in the reaction tank (1) and the tank cover (2) through the second connecting pipe (26), the filter chamber (21) and the first connecting pipe (22), and after the air is pumped out, the second valve (23) is closed and the vacuum pump (27) is stopped;
C. stirring reaction, starting a motor (7), driving a transmission shaft (9), a turntable (8) and a driving wheel (10) to rotate through the motor (7), and driving a plurality of rotating shafts (12) to rotate through the mutual matching of the driving wheel (10) and a plurality of driven wheels (11), so that stirring blades (13) revolve around the driving wheel (10) as a center, rotate around the rotating shafts (12) as a center and stir the materials in the reaction tank (1), and the materials are mixed and reacted to obtain the acetylcatapril;
D. discharging materials, opening a first valve (20) after the reaction is finished to balance the air pressure in the reaction tank (1) with the outside, and then rotating a sealing cover (4) to separate the sealing cover (4) from a discharging pipe (3) so as to discharge the acetyl captopril in the reaction tank (1);
E. cleaning a filter screen (19), namely holding a push rod (18) and rotating a support ring (17) through the push rod (18) to separate the support ring (17) from a support cover (16), then cleaning the filter screen (19) by using the existing equipment, and screwing the support ring (17) into the support cover (16) after cleaning;
F. the method comprises the following steps of cleaning the filter cotton (24), rotating the plugging cover (25) to separate the plugging cover (25) from the filter chamber (21), pulling the filter cotton (24) downwards to take the filter cotton (24) out of the filter chamber (21), cleaning materials on the filter cotton (24), putting the cleaned filter cotton (24) back into the filter chamber (21), and screwing the plugging cover (25) onto the filter chamber (21).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202010678163.0A CN111686673A (en) | 2020-07-15 | 2020-07-15 | Device and improved technology for preparing acetyl captopril |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010678163.0A CN111686673A (en) | 2020-07-15 | 2020-07-15 | Device and improved technology for preparing acetyl captopril |
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| CN111686673A true CN111686673A (en) | 2020-09-22 |
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| CN202010678163.0A Pending CN111686673A (en) | 2020-07-15 | 2020-07-15 | Device and improved technology for preparing acetyl captopril |
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