CN111685785B - Method and device for correcting position lookup table of PET (polyethylene terephthalate) crystal and computer equipment - Google Patents
Method and device for correcting position lookup table of PET (polyethylene terephthalate) crystal and computer equipment Download PDFInfo
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Abstract
The application relates to a method and a device for correcting a PET crystal position lookup table and a computer device, wherein the method for correcting the PET crystal position lookup table comprises the following steps: acquiring background events of self radiation particles received by a detector from a detector crystal; obtaining a single event image according to the background event; and correcting the PET crystal position lookup table according to the single-event image. By detecting the inherent radiation phenomenon of the background of the patient, the use of a radioactive source is avoided, the radiation dose of a doctor is reduced, the use cost of a hospital is reduced, and compared with active detection, the operation is simple, and the correction can be carried out at any time.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a method and a device for correcting a position lookup table of a PET crystal and computer equipment.
Background
Positron Emission Tomography (PET) is a relatively advanced clinical examination imaging technique in the field of nuclear medicine. The general method is to mix a certain substance, which is generally necessary in the metabolism of biological life, such as: glucose, protein, nucleic acid, fatty acid, short-lived radionuclides (such as F18, carbon 11, etc.) labeled with these substances are injected into the human body, and the aggregation of these substances in the metabolism reflects the metabolic activity of the life, so that the purpose of diagnosis is achieved. Because positron emission computed tomography has the characteristics of high sensitivity, high specificity, good safety and the like, positron emission computed tomography is more widely applied. Before scanning with a PET device, a look-up table (LUT) for PET crystal positions is usually corrected to ensure the accuracy of data acquired by the PET device, and thus the high resolution of a reconstructed image.
The current traditional technology uses positron emission barrel sources or rod sources such as Ge-68 and Na-22 to carry out the position lookup table correction of the PET crystal. But can cause some radiological damage to the physician due to the presence of the radioactive source. The dosage of radiation to the doctor is increased, and the operation flow is complex and only suitable for regular detection.
Disclosure of Invention
The embodiment of the application provides a method and a device for correcting a PET crystal position lookup table and computer equipment, which are used for at least solving the problems of high radiation dose and complex operation process of a doctor in the related art.
In a first aspect, an embodiment of the present application provides a method for correcting a PET crystal position lookup table, including: acquiring background events of self radiation particles received by a detector from a detector crystal; obtaining a single event image according to the background event; and correcting the PET crystal position lookup table according to the single-event image.
In one embodiment, the acquiring background events received by the detector from the radiation particles of the detector crystal itself includes: presetting an energy window of a detector; and acquiring background events of radiation particles received by the detector from the detector crystal according to the preset energy window.
In one embodiment, the value of the energy window is within a PET system clinical energy window threshold.
In one embodiment, the obtaining a single-event image according to the background event includes: obtaining a single characteristic energy peak event according to the background event; and generating a single-event image according to the single characteristic energy peak event.
In one embodiment, the single characteristic energy peak event comprises the event that a 596keV photon is received.
In one embodiment, the correcting the PET crystal position lookup table according to the single-event image comprises: acquiring corresponding pixel distribution of the crystal position labels in the single event image according to the single event image; and correcting the PET crystal position lookup table according to the corresponding pixel distribution of the crystal position labels in the single-event image.
In a second aspect, the present application provides a correction apparatus for a PET crystal position lookup table, including: the acquisition module is used for acquiring background events of self radiation particles received by the detector from the detector crystal; the screening module is used for obtaining a single event image according to the background event; and the correction module is used for correcting the PET crystal position lookup table according to the single-event image.
In one embodiment, the correction module is further configured to obtain, according to the single-event image, a corresponding pixel distribution of a crystal position label in the single-event image; and correcting the PET crystal position lookup table according to the corresponding pixel distribution of the crystal position labels in the single-event image.
In a third aspect, the present application provides a computer device, which includes a memory, a processor, and a computer program stored on the memory and executable on the processor, and the processor executes the computer program to implement the method for correcting the PET crystal position lookup table according to the first aspect.
In a fourth aspect, the present application provides a computer-readable storage medium, on which a computer program is stored, which when executed by a processor implements the method for correcting the PET crystal position lookup table according to the first aspect.
Compared with the related art, the method for correcting the PET crystal position lookup table provided by the embodiment of the application obtains the background events received by the detector and coming from the self radiation particles of the detector; and obtaining a single event image according to the background event, and finally correcting the PET crystal position lookup table according to the single event image. By detecting the inherent radiation phenomenon of the background of the patient, the radiation source is avoided, the radiation dose of a doctor is reduced, the use cost of a hospital is reduced, and compared with active detection, the method is simple to operate and can be used for correction at any time.
The details of one or more embodiments of the application are set forth in the accompanying drawings and the description below to provide a more thorough understanding of the application.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the application and together with the description serve to explain the application and not to limit the application. In the drawings:
FIG. 1 is a flow chart of a method for calibrating a PET crystal position lookup table in one embodiment;
FIG. 2 is a single event image in one embodiment;
FIG. 3 is a block diagram showing a correction device for a PET crystal position lookup table according to an embodiment;
fig. 4 is a schematic hardware configuration diagram of a computer device in one embodiment.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application will be described and illustrated below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application. All other embodiments obtained by a person of ordinary skill in the art based on the embodiments provided in the present application without any inventive step are within the scope of protection of the present application.
It is obvious that the drawings in the following description are only examples or embodiments of the application, and that it is also possible for a person skilled in the art to apply the application to other similar contexts on the basis of these drawings without inventive effort. Moreover, it should be appreciated that in the development of any such actual implementation, as in any engineering or design project, numerous implementation-specific decisions must be made to achieve the developers' specific goals, such as compliance with system-related and business-related constraints, which may vary from one implementation to another.
Reference in the specification to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the specification. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of ordinary skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments without conflict.
Unless otherwise defined, technical or scientific terms referred to herein should have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The use of the terms "a" and "an" and "the" and similar referents in the context of describing the invention (including a single reference) are to be construed in a non-limiting sense as indicating either the singular or the plural. The use of the terms "including," "comprising," "having," and any variations thereof herein, is meant to cover a non-exclusive inclusion; for example, a process, method, system, article, or apparatus that comprises a list of steps or modules (elements) is not limited to the listed steps or elements, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus. Reference to "connected," "coupled," and the like in this application is not intended to be limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. The term "plurality" as used herein means two or more. "and/or" describes an association relationship of associated objects, meaning that three relationships may exist, for example, "A and/or B" may mean: a exists alone, A and B exist simultaneously, and B exists alone. The character "/" generally indicates that the former and latter associated objects are in an "or" relationship. Reference herein to the terms "first," "second," "third," and the like, are merely to distinguish similar objects and do not denote a particular ordering for the objects.
Positron Emission Tomography (PET) is an advanced clinical examination imaging technology in the field of nuclear medicine. Is to take a certain substance, which is generally necessary in the metabolism of biological life, such as: glucose, protein, nucleic acid, fatty acid, short-lived radionuclides (such as 18F, 11C, etc.) labeled with a label, when injected into a human body, the radionuclides release positrons during decay, and a positron travels from a few tenths of a millimeter to a few millimeters and encounters an electron to be annihilated, thereby generating a pair of photons with energy of 511KeV in opposite directions. This is a pair of photons captured by a highly sensitive camera and corrected for scatter and random information by a computer. By carrying out the same analysis processing on different positrons, a three-dimensional image of the aggregation condition in a living body can be obtained, thereby achieving the purpose of diagnosis.
The detectors of PET equipment are typically comprised of a structure of scintillation crystal arrays coupled to photoelectric conversion devices. The scintillation crystal receives gamma photon pairs generated by annihilation events in the imaging process and converts the gamma photon pairs into visible light; the photoelectric converter receives the optical signals, converts the optical signals into corresponding electric signals, amplifies the electric signals and outputs the electric signals to the back-end circuit for processing. Ideally, the correspondence between the physical location of the crystal array receiving the annihilation effect gamma photons and the location decoded onto the image should be linear. However, the compton scattering effect in the encoding process, the non-uniformity of the physical material of each crystal, and the non-linear response of the related electronic components cause the correspondence between the two to be in a non-linear relationship. The accuracy of gamma photon incident position detection is a precondition for ensuring the image resolution of the PET system. Therefore, in order to find the correspondence between the crystal and the image, it is necessary to establish a PET crystal position lookup table by which the accurate reception position of the γ photon is determined.
Yttrium lutetium silicate scintillating crystals (LYSO) are used as scintillating crystals of PET equipment due to their characteristics of high light output, fast luminescence decay, many effective atomic numbers, large density, stable physicochemical properties, high gamma ray detection efficiency and the like. Because of the Lu176 in LYSO, which has inherent emission phenomenon, Lu176 releases gamma photons with three energies of 88kev, 202kev and 307kev respectively and beta particles with energy random range of 0 to 593kev during decay.
The method for correcting the PET crystal position lookup table provided in this embodiment collects instances of a fixed energy interval by using a background intrinsic radiation phenomenon of a detector under a condition without a radiation source for a PET detector module formed by coupling a crystal array and a photosensitive detector which are regularly arranged, forms a single-event image, and calibrates and corrects the crystal-image mapping lookup table through the single-event image.
The embodiment also provides a method for correcting the position lookup table of the PET crystal. Fig. 1 is a flowchart of a method for correcting a PET crystal position lookup table according to an embodiment of the present application, and as shown in fig. 1, the flowchart includes the following steps:
and step S102, acquiring background events of self radiation particles received by the detector from the detector crystal.
Specifically, the detector crystal is yttrium lutetium silicate scintillation crystal (LYSO), and due to the presence of Lu176 in LYSO, when Lu176 decays, beta particles and gamma photons are generated. Wherein the beta particles are absorbed immediately in the decaying detector crystal, the gamma photons need to reach the opposite crystal through the whole field of view to be absorbed by the corresponding detector crystal, the connecting line of the detector crystals receiving the beta particles and the gamma photons is called a response line, and the event of the detector receiving the beta particles and the gamma photons is called a background event. After receiving the beta particle or gamma photon, the detector crystal will record the corresponding particle arrival time or photon arrival time and particle energy or photon energy.
In one embodiment, before acquiring the background event of the radiation particles of the detector crystal itself, an energy window of the detector needs to be preset, and the background event of the radiation particles of the detector crystal itself received by the detector is acquired according to the preset energy window. The energy window is selected mainly according to the energy resolution, and the small energy window can be selected according to the good energy resolution. In this embodiment, to better accommodate the inherent radioactivity of the LYSO background, the low-energy background radiation particles received are filtered out by setting the appropriate energy window. Preferably, the value of the energy window is within a PET system clinical energy window threshold. More specifically, a large amount of data of PET energy window threshold values of different hospitals in different areas are obtained in the practical application process of the PET system, and the clinical energy window threshold value range of the PET system is obtained through statistics of the large amount of data; the preset detector energy window in this embodiment is within the threshold range of the clinical energy window of the corresponding PET system to ensure better acquisition of background events. After the energy window of the PET system is determined, background coincidence events are acquired from the energy window.
And step S104, obtaining a single-event image according to the background event.
Specifically, a single characteristic energy peak event is obtained according to the background event; and generating a single-event image according to the single characteristic energy peak event. Specifically, a corresponding energy spectrum is formed based on the recorded particle energy or photon energy after the detector receives the beta particle or gamma photon in the background event. Wherein, because Lu176 releases gamma photons with three energies of 88kev, 202kev and 307kev and beta particles with the energy random range of 0 kev-593 kev in the process of attenuation. Energy superposition is generated among the three gamma photons and the beta particles, so that a single characteristic energy peak event in the generated energy spectrogram comprises a characteristic energy peak event formed by superposing 88kev photons and the beta particles, a characteristic energy peak event formed by superposing 202kev and the beta particles, a characteristic energy peak event formed by superposing 307kev photons and the beta particles, and a characteristic energy peak event of 596 kev. Preferably, the single characteristic energy peak event used in the present embodiment includes the event of receiving a 596keV photon. A single event image is generated from the single characteristic energy peak events of the received 596keV photons. Theoretically, a characteristic energy peak event of 596keV is directly adopted to construct a single-event image, but due to scattering of photons and errors caused by electronic measurement, data obtained through actual measurement has a certain spread Gaussian distribution, so that when the single-event image is constructed, the single-event image needs to be generated according to the characteristic energy peak event of 596keV and the characteristic energy peak event of a certain energy range around the characteristic energy peak event of 596 keV.
And S106, correcting the PET crystal position lookup table according to the single-event image.
Specifically, according to the single event image, obtaining the corresponding pixel distribution of the crystal position labels in the single event image; and correcting the PET crystal position lookup table according to the corresponding pixel distribution of the crystal position labels in the single-event image. As shown in fig. 2, fig. 2 is a single-event image in one embodiment. The single-event image represents an image formed by deposition of photons of fixed energy received by the detector crystal array, and each bright spot cluster in the single-event image represents a mapping position of one detector crystal in the image. Each detector crystal corresponds to a detector crystal position label according to the position of the detector crystal in the detector, namely each bright spot cluster in the single-event image corresponds to a detector crystal position label. Therefore, according to the single-event image, the corresponding relation between each pixel point in the single-event image and the position number of the detector crystal can be obtained. And correcting the PET crystal position lookup table according to the corresponding relation between each pixel point in the single-event image and the detector crystal position number.
In one embodiment, the crystal detector obtains a coincidence event generated by the background event according to the corrected PET crystal position lookup table to form a coincidence event image containing background event energy information, and performs secondary correction on the PET crystal position lookup table according to the coincidence event image containing the background event energy information to obtain a secondary corrected PET crystal position lookup table, wherein the secondary corrected PET crystal position lookup table can more accurately position and receive the crystal position of the coincidence event.
The method for correcting the PET crystal position lookup table provided in this embodiment corrects the PET crystal position lookup table of the detector module by using a single-event image generated by background intrinsic radiation of the detector, collects a background event under a wide energy window condition to perform simple peak finding calculation, discriminates 596keV gamma characteristic peak events generated by natural decay of Lu-176 in the crystal received by the detector crystal through a limited energy window width, generates a single-event image according to the 596keV gamma characteristic peak events, and corrects the PET crystal position lookup table of the detector module through the single-event image. By using the correction method, the use of a radioactive source in daily correction operation can be effectively avoided, the correction process can be simplified, the background data of the PET equipment under the condition of no patient scanning is effectively utilized, the correction frequency is improved, the PET equipment can be subjected to iterative correction optimization in a self-adaptive manner, and the machine performance is improved.
The correction method for the PET crystal position lookup table provided by this embodiment filters low-energy background events by limiting an energy window, and acquires single-event data of a detector to obtain a single-event image of a 596keV γ characteristic peak case generated by natural decay of the crystal Lu-176. The peak-to-valley distribution is substantially similar to the single event image obtained with the Na-22 source for the 511keV gamma characteristic peak case. And correcting the PET crystal position lookup table according to the similar single-event image, and performing PET detector coincidence acquisition by using the corrected PET crystal position lookup table, so that the resolution of the PET equipment can be improved.
According to the correction method of the PET crystal position lookup table, background events of self radiation particles received by the detector from the detector are obtained; and obtaining a single event image according to the background event, and finally correcting the PET crystal position lookup table according to the single event image. By detecting the inherent radiation phenomenon of the background of the patient, the radiation source is avoided, the radiation dose of a doctor is reduced, the use cost of a hospital is reduced, and compared with active detection, the method is simple to operate and can be used for correction at any time.
It should be noted that the steps illustrated in the above-described flow diagrams or in the flow diagrams of the figures may be performed in a computer system, such as a set of computer-executable instructions, and that, although a logical order is illustrated in the flow diagrams, in some cases, the steps illustrated or described may be performed in an order different than here.
The present embodiment further provides a calibration apparatus for a PET crystal position lookup table, which is used to implement the foregoing embodiments and preferred embodiments, and the description of the apparatus is omitted here. As used hereinafter, the terms "module," "unit," "subunit," and the like may implement a combination of software and/or hardware for a predetermined function. Although the means described in the embodiments below are preferably implemented in software, an implementation in hardware, or a combination of software and hardware is also possible and contemplated.
FIG. 3 is a block diagram of a correction device for a PET crystal position lookup table according to an embodiment, as shown in FIG. 3, the device includes: an acquisition module 100, an image generation module 200, and a correction module 300.
The acquisition module 100 is configured to acquire background events received by the detector from the self-radiation particles of the detector crystal;
an image generating module 200, configured to obtain a single-event image according to the background event;
and the correcting module 300 is used for correcting the PET crystal position lookup table according to the single-event image.
The acquisition module 100 is further configured to preset an energy window of the detector; and acquiring background events of radiation particles received by the detector from the detector crystal according to the preset energy window.
The image generation module 200 is further configured to obtain a single characteristic energy peak event according to the background event; and generating a single-event image according to the single characteristic energy peak event.
The correction module 300 is further configured to obtain, according to the single-event image, a corresponding pixel distribution of the crystal position label in the single-event image; and correcting the PET crystal position lookup table according to the corresponding pixel distribution of the crystal position labels in the single-event image.
The above modules may be functional modules or program modules, and may be implemented by software or hardware. For a module implemented by hardware, the modules may be located in the same processor; or the modules can be respectively positioned in different processors in any combination.
In addition, the method for correcting the PET crystal position lookup table in the embodiment of the present application described in conjunction with fig. 1 can be implemented by a computer device. Fig. 4 is a schematic hardware configuration diagram of a computer device in one embodiment.
The correction device for the PET crystal position look-up table may comprise a processor 41 and a memory 42 in which computer program instructions are stored.
Specifically, the processor 41 may include a Central Processing Unit (CPU), or A Specific Integrated Circuit (ASIC), or may be configured to implement one or more Integrated circuits of the embodiments of the present Application.
The processor 41 reads and executes the computer program instructions stored in the memory 42 to realize the correction method of the PET crystal position lookup table in any one of the above embodiments.
In some of these embodiments, the computer device may also include a communication interface 43 and a bus 40. As shown in fig. 4, the processor 41, the memory 42, and the communication interface 43 are connected via the bus 40 to complete mutual communication.
The communication interface 43 is used for implementing communication between modules, devices, units and/or apparatuses in the embodiments of the present application. The communication port 43 may also be implemented with other components such as: the data communication is carried out among external equipment, image/data acquisition equipment, a database, external storage, an image/data processing workstation and the like.
The computer device can execute the correction method of the PET crystal position lookup table in the embodiment of the present application based on the acquired computer instructions, thereby implementing the correction method of the PET crystal position lookup table described in conjunction with fig. 1.
In addition, in combination with the method for correcting the PET crystal position lookup table in the above embodiments, the embodiments of the present application can be implemented by providing a computer readable storage medium. The computer readable storage medium having stored thereon computer program instructions; the computer program instructions can be executed by a processor to realize the method for correcting the PET crystal position lookup table in any one of the above embodiments.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A method for correcting a PET crystal position lookup table is characterized by comprising the following steps:
acquiring background events of self radiation particles received by a detector from a detector crystal;
obtaining a single event image according to the background event;
correcting a PET crystal position lookup table according to the single-event image;
and acquiring a coincidence event generated by the background event according to the corrected PET crystal position lookup table, forming a coincidence event image containing the background event energy information, and performing secondary correction on the PET crystal position lookup table according to the coincidence event image containing the background event energy information to acquire a secondary corrected PET crystal position lookup table.
2. The calibration method of claim 1, wherein said acquiring background events received by the detector from the detector crystal's own radiation particles comprises:
presetting an energy window of a detector;
and acquiring background events of radiation particles received by the detector from the detector crystal according to the preset energy window.
3. The correction method according to claim 2,
the value of the energy window is within a PET system clinical energy window threshold.
4. The method of claim 1, wherein said deriving a single-event image from the background event comprises:
obtaining a single characteristic energy peak event according to the background event;
and generating a single-event image according to the single characteristic energy peak event.
5. The correction method according to claim 4,
the single characteristic energy peak event comprises an event of receiving a 596keV photon.
6. The correction method according to claim 4, wherein the correcting the PET crystal position lookup table from the single-event image comprises:
acquiring corresponding pixel distribution of the crystal position labels in the single event image according to the single event image;
and correcting the PET crystal position lookup table according to the corresponding pixel distribution of the crystal position labels in the single-event image.
7. A correction device for a PET crystal position lookup table, comprising:
the acquisition module is used for acquiring background events of self radiation particles received by the detector from the detector crystal;
the image generation module is used for obtaining a single-event image according to the background event;
the correction module is used for correcting the PET crystal position lookup table according to the single-event image;
The correction module is further configured to obtain a coincidence event generated by the background event according to the corrected PET crystal position lookup table, form a coincidence event image including the background event energy information, and perform secondary correction on the PET crystal position lookup table according to the coincidence event image including the background event energy information, so as to obtain a secondary corrected PET crystal position lookup table.
8. The calibration device of claim 7,
the correction module is further used for acquiring corresponding pixel distribution of the crystal position labels in the single event image according to the single event image; and correcting the PET crystal position lookup table according to the corresponding pixel distribution of the crystal position labels in the single-event image.
9. A computer device comprising a memory, a processor and a computer program stored on the memory and executable on the processor, characterized in that the processor implements the correction method of the PET crystal position lookup table according to any one of claims 1 to 6 when executing the computer program.
10. A computer-readable storage medium on which a computer program is stored, which when executed by a processor implements the method of correcting a PET crystal position lookup table as claimed in any one of claims 1 to 6.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010604531.7A CN111685785B (en) | 2020-06-29 | 2020-06-29 | Method and device for correcting position lookup table of PET (polyethylene terephthalate) crystal and computer equipment |
| EP21814520.9A EP4144296A4 (en) | 2020-05-25 | 2021-05-25 | State detection method and system for imaging device |
| JP2022572797A JP7512440B2 (en) | 2020-05-25 | 2021-05-25 | Method and system for detecting the state of an image forming apparatus |
| PCT/CN2021/095840 WO2021238929A1 (en) | 2020-05-25 | 2021-05-25 | State detection method and system for imaging device |
| US18/058,785 US20230102139A1 (en) | 2020-05-25 | 2022-11-25 | Systems and methods for state detection of imaging devices |
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| CN112690818B (en) * | 2020-12-29 | 2022-06-17 | 赛诺联合医疗科技（北京）有限公司 | Correction method of crystal position lookup table of PET detector and PET system |
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| CN107507164A (en) * | 2017-07-11 | 2017-12-22 | 北京永新医疗设备有限公司 | The acquisition methods of bimorph crystal location lookup table |
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| CN107507164A (en) * | 2017-07-11 | 2017-12-22 | 北京永新医疗设备有限公司 | The acquisition methods of bimorph crystal location lookup table |
| CN107242881A (en) * | 2017-08-15 | 2017-10-13 | 中日友好医院 | A kind of PET crystal positions search table updating method |
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