CN111674062A - Silicification method of rubber cone head protective cap for pre-filling and sealing injector - Google Patents
Silicification method of rubber cone head protective cap for pre-filling and sealing injector Download PDFInfo
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- CN111674062A CN111674062A CN202010466147.5A CN202010466147A CN111674062A CN 111674062 A CN111674062 A CN 111674062A CN 202010466147 A CN202010466147 A CN 202010466147A CN 111674062 A CN111674062 A CN 111674062A
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- Prior art keywords
- protective cap
- rubber cone
- cleaning machine
- silicone oil
- cap
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C71/00—After-treatment of articles without altering their shape; Apparatus therefor
- B29C71/0009—After-treatment of articles without altering their shape; Apparatus therefor using liquids, e.g. solvents, swelling agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C71/00—After-treatment of articles without altering their shape; Apparatus therefor
- B29C71/0009—After-treatment of articles without altering their shape; Apparatus therefor using liquids, e.g. solvents, swelling agents
- B29C2071/0045—Washing using non-reactive liquids
Abstract
The invention discloses a silicification method of a rubber cone head protective cap for a pre-filling and sealing injector, which is characterized by comprising the following steps: (1) charging, introducing water, and adding silicone oil; (2) ultrasonic rotation silicification; (3) vacuum exhausting; (4) repeating the step (2) and the step (3); (5) and (5) draining water, and drying in vacuum to obtain the rubber conical head protective cap for the pre-filled and sealed syringe with the inner wall uniformly silicided. The diameter of the receiving part of the rubber cone head protective cap nozzle for the prefilled syringe is small, silicone oil is difficult to enter, and the inner wall is difficult to silicify.
Description
Technical Field
The invention belongs to the technical field of medicine packaging production, and particularly relates to a silicification method of a rubber cone head protective cap for a pre-filled syringe.
Background
The pre-filled syringe is widely accepted and applied due to the characteristics of convenient use, no need of liquid medicine transfer, high safety and the like, and the rubber cone head protective cap is an important part of the pre-filled syringe and is matched with a syringe nozzle to play a role in sealing in the processes of medicine sterilization and long-term storage. When the medicine is injected, the protective cap needs to be removed firstly, a needle is arranged for injection administration, in order to ensure the sealing property, the aperture of the receiving part of the injection nozzle of the rubber protective cap is usually smaller than the outer diameter of the injection nozzle of the injector, and the tight fit between the protective cap and the injection nozzle is ensured.
In order to solve the assembly problem, the medical rubber product is usually subjected to silicification treatment, so that a layer of silicon oil film is attached to the surface of the rubber product, the smoothness of the assembly surface is ensured, and the smooth and convenient removal of the assembly machine is ensured. The common silicification method is that silicone oil is directly added into a cleaning machine in the cleaning process, the silicone oil is uniformly dispersed on the surface of a product through slow stirring, the silicification effect is good for a medical rubber plug, a rubber piston and a gasket, the outer surface of which needs to be silicified, the silicification effect is poor for a rubber cone head protective cap product with a small aperture, the silicification effect is poor because the receiving part of a nozzle of the rubber protective cap is deep and the aperture is small (the depth is about 7.3mm and the aperture is about 3.9 mm), a silicone oil aqueous solution cannot enter the protective cap under the slow stirring, so that the silicification of the inner wall of the protective cap is difficult, the rotating speed resistance is greatly increased under the condition that the cleaning machine is filled with the product and water, a motor can be damaged, the sealing device of the cleaning machine can be abraded, and the silicification effect of the inner wall of the protective cap.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide a silicification method of a rubber cone head protective cap for a pre-filling and sealing syringe, which solves the problems that the inner wall of the protective cap is not silicified uniformly and is adhered to a syringe nozzle, facilitates the removal of the protective cap and reduces the working strength of medical staff.
In order to solve the technical problems, the invention adopts the following technical scheme:
a silicification method of a rubber cone head protective cap for a pre-filling and sealing injector comprises the following steps:
(1) charging, introducing water, adding silicone oil: loading the rubber protective cap into a cleaning machine by adopting a vacuum material suction method; introducing hot water of 80-100 ℃, and slowly adding silicone oil under the condition that the cleaning machine rotates;
(2) ultrasonic rotation silicification: turning on a switch of an ultrasonic generator under the condition that the cleaning machine rotates to promote the silicone oil to be uniformly dispersed in water;
(3) vacuum exhausting: the cleaning machine stops rotating, and the air in the receiving part of the nozzle of the protective cap is exhausted by vacuumizing, so that the silicon oil aqueous solution enters the protective cap;
(4) repeating the step (2) and the step (3) to ensure that the inner wall of the protective cap is uniformly silicided;
(5) draining, and vacuum drying: after the normal pressure in the cleaning machine is recovered, a drain valve is opened, ultrasonic waves are closed at the same time, water is drained completely, and hot air is dried and vacuumized to drain water.
Further, in the step (1), the total surface area of the protective cap is taken as a reference, and the adding amount of the silicone oil is 50-100 mug/cm2。
Further, when adding the silicone oil in the step (1), a proper amount of silicone oil is taken by using a 100mL injector, then 30-40mL of 50-60 ℃ warm water is absorbed, shaken and stirred uniformly, then the mixture is added into a cleaning machine, and the mixture is added slowly under the condition that the machine rotates.
Further, the rotating speed of the cleaning machine is 5-10 r/min.
Further, the ultrasonic rotation silicification time in the step (2) is 3-5 min; the power of the ultrasonic generator is 1500W-2800W, and the frequency is 28 kHz.
Further, in the step (3), the vacuumizing pressure is-0.05 MPa-0.1 MPa, and the vacuumizing time is 1-2 min.
Further, the number of repetitions of step (2) in step (4) is preferably 1 to 2, and the number of repetitions of step (3) is preferably 0 to 1.
Further, the temperature of the hot air in the step (5) is 110-.
The invention has the beneficial effects that: the method of the invention assists in using ultrasonic waves while the cleaning machine is stirring at a low speed, so that silicon oil is uniformly dispersed in hot water, and then the air in the receiving part of the injection nozzle of the protective cap is discharged by vacuumizing, so that the silicon oil aqueous solution enters the protective cap, the inner wall of the protective cap is uniformly silicided, and the rubber protective cap silicided by the method can not be adhered in the processes of sterilization and long-term storage after being assembled with an injector, is convenient to remove during administration, lightens the working strength of medical staff, and improves the working efficiency; meanwhile, the method has simple process, no pollution and easy industrial application.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
Example 1
A silicification method of a rubber cone head protective cap for a pre-filling and sealing injector comprises the following steps:
(1) loading the rubber protective cap into a cleaning machine by a vacuum material suction method, introducing a certain amount of hot water with the water temperature of 80 ℃, sucking silicon oil and warm water by using an injector, mixing uniformly, slowly adding into the rotating cleaning machine, wherein the amount of the silicon oil is 50 microgram/cm2Calculating addition;
(2) keeping the rotating speed of the cleaning machine at 10r/min, turning on an ultrasonic generator, and ultrasonically rotating and siliconizing for 3min under the conditions of 28kHz and 2800W;
(3) vacuumizing for 2min, and keeping the vacuum degree at-0.05 MPa;
(4) repeating the step (2) and the step (3), and repeating the step (2);
(5) draining, and vacuum drying at 110 deg.C for 130min to obtain rubber cap for prefilled syringe.
The results of the adhesion test after sterilization of the rubber cap and 2ml COP syringe are shown in Table 1.
TABLE 1 results of adhesion test of rubber cone cap and nozzle of 2ml COP syringe after sterilization
Example 2
A silicification method of a rubber cone head protective cap for a pre-filling and sealing injector comprises the following steps:
(1) loading materials by a vacuum material suction method, introducing 100 ℃ hot water, and pressing according to 100 microgram/cm2Adding silicone oil;
(2) keeping the rotating speed of the cleaning machine at 5r/min, turning on an ultrasonic generator, and ultrasonically rotating and siliconizing for 5min under the conditions of 28kHz and 2800W;
(3) vacuumizing for 1min, and keeping the vacuum degree at-0.1 MPa;
(4) repeating the step (2);
(5) draining, and vacuum drying at 120 deg.C for 100min to obtain rubber cap for prefilled syringe.
The results of the adhesion test after sterilization and accelerated storage of the rubber cap obtained in combination with a 2ml COP syringe are shown in Table 2.
TABLE 2 results of adhesion test between rubber cap and nozzle of 2ml COP syringe after sterilization and accelerated storage
| Sterilization conditions | Acceleration conditions | Number of trials | Test results | |
| Silicification by conventional methods | 121℃*15min | 30 days at 60 DEG C | 30 pieces of | 18 pieces of adhesion |
| The method of the invention comprises silicification | 121℃*15min | 30 days at 60 DEG C | 30 pieces of | 0 sticking |
Note: the general method comprises the following steps: directly adding the silicone oil into a cleaning machine in the cleaning process, and uniformly dispersing the silicone oil on the surface of the product by slow stirring.
From the above test results, it can be seen that the rubber cap siliconized by the method of the present invention does not adhere to the nozzle of the syringe during sterilization and acceleration, and has significant advantages compared with the ordinary siliconizing method.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (8)
1. A silicification method of a rubber cone head protective cap for a pre-filling and sealing injector is characterized by comprising the following steps:
(1) charging, introducing water, adding silicone oil: loading the rubber protective cap into a cleaning machine by adopting a vacuum material suction method; introducing hot water, and slowly adding silicone oil under the condition that the cleaning machine rotates;
(2) ultrasonic rotation silicification: turning on a switch of an ultrasonic generator under the condition that the cleaning machine rotates to promote the silicone oil to be uniformly dispersed in water;
(3) vacuum exhausting: the cleaning machine stops rotating, and the air in the receiving part of the nozzle of the protective cap is exhausted by vacuumizing, so that the silicon oil aqueous solution enters the protective cap;
(4) repeating the step (2) and the step (3) to ensure that the inner wall of the protective cap is uniformly silicided;
(5) draining, and vacuum drying: after the normal pressure in the cleaning machine is recovered, a drain valve is opened, ultrasonic waves are closed at the same time, water is drained completely, and hot air is dried and vacuumized to drain water.
2. The siliconizing method of the rubber cone cap for the pre-potting syringe according to claim 1, wherein: in the step (1), the total surface area of the protective cap is taken as a reference, and the addition amount of the silicone oil is 50-100 mug/cm2。
3. The siliconizing method of the rubber cone cap for the pre-potting syringe according to claim 1, wherein: when the silicone oil is added in the step (1), a proper amount of silicone oil is taken by using a 100mL syringe, then 30-40mL warm water is absorbed, the mixture is shaken up and then added into a cleaning machine, and the mixture is slowly added under the condition that the machine rotates.
4. The siliconizing method of the rubber cone cap for the pre-potting syringe according to claim 1, wherein: the rotating speed of the cleaning machine is 5-10 r/min.
5. The siliconizing method of the rubber cone cap for the pre-potting syringe according to claim 1, wherein: the ultrasonic rotation silicification time in the step (2) is 3-5 min; the power of the ultrasonic generator is 1500W-2800W, and the frequency is 28 kHz.
6. The siliconizing method of the rubber cone cap for the pre-potting syringe according to claim 1, wherein: in the step (3), the vacuumizing pressure is-0.05 MPa-0.1 MPa, and the vacuumizing time is 1-2 min.
7. The siliconizing method of the rubber cone cap for the pre-potting syringe according to claim 1, wherein: the repetition frequency of the step (2) in the step (4) is preferably 1 to 2 times, and the repetition frequency of the step (3) is preferably 0 to 1 time.
8. The siliconizing method of the rubber cone cap for the pre-potting syringe according to claim 1, wherein: the temperature of the hot air in the step (5) is 110-120 ℃, and the drying time is 100-130 min.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010466147.5A CN111674062B (en) | 2020-05-28 | 2020-05-28 | Silicification method of rubber conical head protective cap for pre-filling and sealing syringe |
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| CN202010466147.5A CN111674062B (en) | 2020-05-28 | 2020-05-28 | Silicification method of rubber conical head protective cap for pre-filling and sealing syringe |
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| CN111674062A true CN111674062A (en) | 2020-09-18 |
| CN111674062B CN111674062B (en) | 2022-08-19 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112871926A (en) * | 2021-02-05 | 2021-06-01 | 郑州翱翔医药科技股份有限公司 | Cleaning method of medical cylindrical rubber product |
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| CN102140323A (en) * | 2010-12-29 | 2011-08-03 | 东莞市冠辉五金有限公司 | High adhesive force dipping-adhesive manufacturing process |
| KR101074525B1 (en) * | 2011-06-07 | 2011-10-17 | 권병선 | Manufacturing method of sealing material |
| CN102516856A (en) * | 2011-11-30 | 2012-06-27 | 马河卫 | Preparation and coating method of non-adhesive paint for ceramic sanitary wares |
| CN105111488A (en) * | 2015-09-28 | 2015-12-02 | 郑州翱翔医药科技股份有限公司 | Production method of medicinal rubber plug |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2279965Y (en) * | 1996-12-20 | 1998-04-29 | 陈国华 | Multi-function, fully automatic rubber plug cleaning-washing machine |
| CN2375391Y (en) * | 1999-05-07 | 2000-04-26 | 温州亚光机械制造有限公司 | Full-automatic wet ultrasonic rubber-plug cleaner |
| CN102140323A (en) * | 2010-12-29 | 2011-08-03 | 东莞市冠辉五金有限公司 | High adhesive force dipping-adhesive manufacturing process |
| KR101074525B1 (en) * | 2011-06-07 | 2011-10-17 | 권병선 | Manufacturing method of sealing material |
| CN102516856A (en) * | 2011-11-30 | 2012-06-27 | 马河卫 | Preparation and coating method of non-adhesive paint for ceramic sanitary wares |
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| CN112871926A (en) * | 2021-02-05 | 2021-06-01 | 郑州翱翔医药科技股份有限公司 | Cleaning method of medical cylindrical rubber product |
| CN112871926B (en) * | 2021-02-05 | 2022-01-21 | 郑州翱翔医药科技股份有限公司 | Cleaning method of medical cylindrical rubber product |
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