CN111671418A - Event-related potential acquisition method and system considering brain working state - Google Patents
Event-related potential acquisition method and system considering brain working state Download PDFInfo
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Abstract
The invention provides an event-related potential acquisition method considering brain working state, which comprises the following steps: s1, acquiring electroencephalogram signals of a testee in a current brain working state in real time through an electroencephalogram signal collector; s2, transmitting the electroencephalogram signals to an upper computer in real time for analysis; s3, judging whether the electroencephalogram signals accord with stimulation receiving expectation or not through the upper computer, if so, presenting stimulation to the testee through the upper computer, and marking the electroencephalogram signals corresponding to the stimulation; otherwise, not processing; and S4, intercepting the marked electroencephalogram signals, and accumulating and averaging to obtain event-related potentials. The invention also provides an event-related potential acquisition system considering the brain working state, which solves the problem that the real event-related potential reflecting the stimulation of the human brain cannot be obtained without considering the brain working state of a testee when the event-related potential is acquired by using the traditional acquisition method, and improves the accuracy of event-related potential acquisition.
Description
Technical Field
The invention relates to the technical field of event-related potential acquisition, in particular to an event-related potential acquisition method and system considering brain working state.
Background
The event-related potential is a potential change generated in a brain area when a specific stimulus is applied to a certain part of the sensory system or the brain and a stimulus is given or removed and a certain psychological factor appears/changes, and is a cognitive potential related to psychological processes such as perception, thinking, attention, memory, intelligence and the like, and is an electrical activity generated in the processes of further processing and processing received information by the brain, identifying, distinguishing, expecting, making a judgment and the like on the received stimulus and preparing to react and the like, the collection of the event-related potential is noninvasive for a testee, and the event-related potential can be used as an objective index for reflecting the higher nervous activity of the brain and is widely applied to the research of cognitive functions.
The traditional method for collecting the event-related potential is that an experimenter compiles a series of stimulations, such as visual, auditory and tactile stimulations, the sequence of each stimulation is randomized, the time interval between the stimulations is randomized in a certain range, the stimulations are presented to a tested person one by one in a selected time period, the electroencephalogram of the tested person is recorded, and the markers of the stimulation are marked on the electroencephalogram. For example, chinese patent publication No. CN103077206A, published as 2013, 5.1.s, discloses a semantic classification search method for pictures based on event-related potentials, which sequentially presents various semantic-related pictures to a user for stimulation before collecting original electroencephalograms generated by the user on the presented pictures, and performs semantic classification search for pictures by using event-related potential signals of the human by using the conventional visual stimulation method, wherein the conventional stimulation is presented to a subject one by one according to a programmed sequence and time intervals, but the current brain working state of the subject is not considered when presenting stimulation to the subject, and what kind of body and heart rhythm the subject is in a day is not considered, which easily causes the obtained event-related potentials not to be truly the response of the human brain to stimulation, and may also cause the event-related potential data to be invalid due to motion artifacts of the subject, which is not conducive to the next application operation by using event-related potential signals, the validity of the application result is not guaranteed.
In summary, it is necessary to provide a method and a system for acquiring event-related potentials in consideration of brain operating states.
Disclosure of Invention
When the traditional method collects the event-related potential, the brain working state of the testee is not considered, so that the obtained event-related potential is not really the response of the human brain to stimulation.
The present invention aims to solve the above technical problem at least to some extent.
In order to achieve the technical effects, the technical scheme of the invention is as follows:
an event-related potential acquisition method considering brain working state at least comprises the following steps:
s1, acquiring electroencephalogram signals of a testee in a current brain working state in real time through an electroencephalogram signal collector;
s2, transmitting the electroencephalogram signals to an upper computer in real time for analysis;
s3, judging whether the electroencephalogram signals accord with stimulation receiving expectation or not through the upper computer, if so, presenting stimulation to the testee through the upper computer, and marking the electroencephalogram signals corresponding to the stimulation; otherwise, not processing;
and S4, intercepting the marked electroencephalogram signals, and accumulating and averaging to obtain event-related potentials.
Preferably, the electroencephalogram signal collector in step S1 is a scalp electroencephalogram electrode, and the number of lead of the scalp electroencephalogram electrode is at least 1.
When the number of leads of the scalp electroencephalogram electrode is 1, the upper computer can already judge whether the electroencephalogram signals in the current brain working state and the brain working state are stimulated and received expectedly, the scalp electroencephalogram electrode with more than 1 lead is generally adopted for collecting event-related potentials, and the more the number of leads is, the higher the accuracy of the collected electroencephalogram signals is.
Preferably, before the step S2, the method further comprises after the step S1: and sequentially amplifying, filtering and AD converting the electroencephalogram signals.
The electroencephalogram signal collector collects electroencephalogram signals of a testee in a current brain working state in real time to be analog signals, and the analog signals are converted into digital signals recognized by the upper computer through AD conversion operation.
Preferably, the method for analyzing by the upper computer in step S2 includes one or any combination of frequency domain analysis, time domain analysis, wavelet transformation, artificial neural network analysis, and nonlinear dynamics analysis.
Preferably, the criterion that the electroencephalogram signal meets the stimulus reception expectation in step S3 is: the power spectrum of the electroencephalogram signal wave is larger than N% of the power spectrum threshold value M, and N is an empirical value.
Here, when the conventional event-related potential is collected, the current electroencephalogram state of the subject is not considered, if the subject moves seriously during the collection process or the subject blinks too frequently, the electroencephalogram artifacts are too many, the available electroencephalogram signal data are few, the obtained event-related potential is not the real response of the human brain to the stimulation, before the stimulation is presented to the subject, whether the electroencephalogram signal of the subject in the brain working state meets the stimulation receiving expectation is judged, the upper computer can judge through one or any combination of frequency domain analysis, time domain analysis, wavelet transformation, artificial neural network analysis and nonlinear dynamics analysis methods, and if the event-related potential under the stimulation W is collected, the upper computer judges whether the electroencephalogram signal under the current brain working state meets the W stimulation receiving expectation or not, so that the stimulation W is not presented randomly relative to the subject, the brain working state is considered, the acquisition result of event-related potential is more accurate, in addition, N is an empirical value because the value of N is determined according to the condition of considering the brain working state in the experiment, the percentage corresponding to N can be larger than 100 or smaller than 100, and the requirements of different electroencephalogram signal waves on power spectral bands are different.
Preferably, the stimulus presented to the subject by the upper computer in step S3 includes one or any combination of auditory stimulus, visual stimulus and tactile stimulus.
Preferably, the power spectrum of the electroencephalogram signal wave corresponding to the current brain working state is obtained on the basis of the determination of the electroencephalogram baseline, and the process of determining the electroencephalogram baseline and obtaining the power spectrum of the electroencephalogram signal wave is as follows:
collecting and recording an electroencephalogram signal of the testee through an electroencephalogram signal collector;
SB. performing mental calculation of quick calculation questions in the time period of t 1-t 2 during the process of acquiring and recording electroencephalogram signals by a test person;
SC. after the subject completes the mental calculation, the frequency domain analysis is carried out to the collected and recorded EEG signal to obtain the real part a and the imaginary part b of the EEG signal frequency spectrum;
SD., obtaining the power spectrum of the EEG signal wave through the real part a and the imaginary part b of the EEG signal frequency spectrum, the formula is:
the pu represents the power spectrum of the electroencephalogram signal wave corresponding to the current brain working state, a represents the real part of the electroencephalogram signal spectrum, and b represents the imaginary part of the electroencephalogram signal spectrum.
Here, the electroencephalogram baseline is measured in advance on the premise that the event-related potential under a certain stimulation to be collected is definite, one electroencephalogram baseline is a basis of an electroencephalogram signal wave corresponding to a brain working state, for example, when the brain working state is an attention focusing state, the corresponding electroencephalogram signal wave is a beta wave, when the brain working state is a meditation state, the corresponding electroencephalogram signal wave is an alpha wave, and the brain working state is considered for the collection of the event-related potential.
Preferably, the process of intercepting the marked electroencephalogram signal and accumulating and averaging to obtain the event-related potential in step S4 includes:
s41, recording the number N of stimuli presented to a testee by the upper computer;
s42, marking the electroencephalogram signal after the ith stimulation, and intercepting △ t from the marking of the electroencephalogram signaliSegment D of electroencephalogram signal in time periodiThe number of the electroencephalogram signal segments is N, i is 1, …, N;
s43, accumulating the intercepted signal data of the N electroencephalogram signal segments and then averaging, namely:
wherein E represents an event-related potential, DiRepresenting the electroencephalogram signal segment intercepted after the ith stimulation.
In the field of signal processing, the signal-to-noise ratio ensures the accuracy of signal extraction, and the improvement of the signal-to-noise ratio is closely related to the superposition times, so that the accuracy of event-related potential acquisition is improved by accumulating the signal data of N electroencephalogram signal segments.
The invention also provides an event-related potential acquisition system considering the brain working state, which is used for realizing the event-related potential acquisition method considering the brain working state and comprises the following steps:
the electroencephalogram signal collector is used for collecting electroencephalogram signals of a testee in a current brain working state in real time, transmitting stimulation to the testee and marking the stimulated electroencephalogram signals;
the upper computer comprises a judgment and analysis module, a stimulation program preset module and an event-related potential generation module, wherein the judgment and analysis module is connected with the stimulation program preset module and judges whether the electroencephalogram signals in the current brain working state accord with stimulation receiving expectation or not after receiving the electroencephalogram signals;
the stimulation program presetting module is provided with a stimulation field device matched with the brain working state, and after the stimulation program presetting module receives the electroencephalogram signals analyzed by the judgment and analysis module in the current brain working state, if the electroencephalogram signals are in accordance with stimulation receiving expectation, the stimulation field device presents stimulation to a testee through an electroencephalogram signal collector;
the event-related potential generation module is provided with a superposition instrument and an event-related potential generator, the superposition instrument carries out accumulation averaging on the intercepted and marked electroencephalogram signals, and the event-related potential generator generates event-related potentials.
The stimulation program presetting module is provided with a stimulation field device matched with the brain working state, and if the event-related potential under the stimulation of W in the stimulation field device is to be collected, the upper computer judges whether the electroencephalogram signal under the current brain working state accords with the expected receiving of the stimulation of W, so that the stimulation of W is not randomly presented relative to a testee, the brain working state is considered, and the collection result of the event-related potential is more accurate.
Preferably, the system further comprises:
the electroencephalogram signal amplifier is used for receiving the electroencephalogram signals collected by the electroencephalogram signal collector and then amplifying the electroencephalogram signals;
the electroencephalogram signal filter receives the electroencephalogram signal amplified by the electroencephalogram signal amplifier and filters the electroencephalogram signal;
and the AD converter is used for converting the filtered electroencephalogram analog signals into electroencephalogram digital signals and transmitting the electroencephalogram digital signals to an upper computer.
Compared with the prior art, the technical scheme of the invention has the beneficial effects that:
before presenting the stimulation acquisition event-related potential to a testee, judging whether an electroencephalogram signal accords with stimulation receiving expectation through an upper computer, presenting stimulation through a stimulation field device, enabling stimulation not to be presented to the testee randomly in the traditional way, but according with the purpose and intention of event-related potential acquisition, considering the brain working state of the testee, and obtaining the event-related potential which is the true response of the human brain to stimulation, so that the acquisition result of the event-related potential is more true and reliable.
Drawings
Fig. 1 is a schematic flow chart of an event-related potential acquisition method considering brain operating states according to the present invention. Fig. 2 is a schematic diagram showing a configuration of an event-related potential acquisition system according to the present invention in consideration of the brain operating state. Fig. 3 is a schematic diagram showing the brain electrical signal alpha wave presentation stimulus in the meditation state according to the embodiment of the present invention.
Detailed Description
The drawings are for illustrative purposes only and are not to be construed as limiting the patent;
for better illustration of the present embodiment, certain parts of the drawings may be omitted, enlarged or reduced, and do not represent actual dimensions;
it will be understood by those skilled in the art that certain well-known illustrations in the drawings may be omitted.
The technical solution of the present invention is further described below with reference to the accompanying drawings and examples.
Example 1
The invention provides an event-related potential acquisition method considering brain working state, a flow diagram of the method is shown in figure 2, and the method comprises the following steps:
s1, acquiring electroencephalogram signals of a testee in a current brain working state in real time through an electroencephalogram signal collector; in this embodiment, the electroencephalogram signal collector is a scalp electroencephalogram electrode, the number of leads of the scalp electroencephalogram electrode is 1, and at this time, the upper computer can already judge whether the electroencephalogram signal in the current brain working state and the brain working state stimulates and receives expectation;
s2, transmitting the electroencephalogram signals to an upper computer in real time for analysis;
s3, judging whether the electroencephalogram signals accord with stimulation receiving expectation or not through the upper computer, if so, presenting stimulation to the testee through the upper computer, and marking the electroencephalogram signals corresponding to the stimulation; otherwise, not processing; in the embodiment, the upper computer analyzes the electroencephalogram signal by adopting a frequency domain analysis method, and judges whether the electroencephalogram signal meets the stimulus receiving expectation or not;
and S4, intercepting the marked electroencephalogram signals, and accumulating and averaging to obtain event-related potentials.
In this embodiment, before step S2, step S1 further includes: the electroencephalogram signal is sequentially amplified, filtered and AD converted, namely before the electroencephalogram signal is transmitted to an upper computer, the electroencephalogram signal is firstly amplified, subsequent filtering is convenient, the subsequent filtering processing effect is better, the electroencephalogram signal is filtered to enable useful electroencephalogram signals to pass through as unattenuated as far as possible, the useless electroencephalogram signals are attenuated, the accuracy of the electroencephalogram signals before AD conversion is guaranteed to be as large as possible, in addition, because an electroencephalogram signal collector collects the electroencephalogram signals of a testee in a current brain working state in real time, the electroencephalogram signals are analog signals, and the analog signals are converted into digital signals recognized by the upper computer through AD conversion operation.
The standard that the electroencephalogram signal meets the stimulation receiving expectation is as follows: the electroencephalogram signals in the current brain working state do not contain electroencephalogram artifacts or are in a blinking state, the power spectrum of electroencephalogram signal waves is larger than N% of a power spectrum threshold value M, whether the electroencephalogram signals corresponding to the current brain working state contain the electroencephalogram artifacts or are in the blinking state is analyzed through an upper computer, the power spectrum threshold value is set according to conditions of specific event-related potential collection and is an empirical value, and the traditional thinking that 80% of the power spectrum threshold value can be stimulated.
The power spectrum of the electroencephalogram signal wave corresponding to the current brain working state is obtained on the basis of the determination of the electroencephalogram baseline, and the process of determining the electroencephalogram baseline and obtaining the power spectrum of the electroencephalogram signal wave is as follows:
collecting and recording an electroencephalogram signal of the testee through an electroencephalogram signal collector;
SB. performing mental calculation of quick calculation questions in the time period of t 1-t 2 during the process of acquiring and recording electroencephalogram signals by a test person;
SC. after the subject completes the mental calculation, the frequency domain analysis is carried out to the collected and recorded EEG signal to obtain the real part a and the imaginary part b of the EEG signal frequency spectrum;
SD., obtaining the power spectrum of the EEG signal wave through the real part a and the imaginary part b of the EEG signal frequency spectrum, the formula is:
the electroencephalogram baseline is determined in advance on the premise that the event-related potential under certain pre-acquired stimulation is definite, the electroencephalogram baseline is the basis of the electroencephalogram waves corresponding to the brain working state, if the brain working state is the attention-focusing state, the corresponding electroencephalogram waves are beta waves, if the brain working state is the meditation state, the corresponding electroencephalogram waves are alpha waves, and the brain working state is considered for acquiring the event-related potential.
In this embodiment, the process of intercepting the marked electroencephalogram signal and accumulating and averaging to obtain the event-related potential in step S4 includes:
s41, recording the number N of stimuli presented to a testee by the upper computer;
s42, marking the electroencephalogram signal after the ith stimulation, and intercepting △ t from the marking of the electroencephalogram signaliSegment D of electroencephalogram signal in time periodiThe number of the electroencephalogram signal segments is N, i is 1, …, N;
s43, accumulating the intercepted signal data of the N electroencephalogram signal segments and then averaging, namely:
wherein E represents an event-related potential, DiRepresenting the segment of the electroencephalogram signal intercepted after the ith stimulus, in particular implementation, △ tiThe length of the time period can be determined by itself, and in the present embodiment, △ tiIs 1000 ms.
As shown in fig. 2, the present invention further provides an event-related potential collecting system considering a brain operating state, which is used for implementing an event-related potential collecting method considering a brain operating state, and includes:
the electroencephalogram signal collector is used for collecting electroencephalogram signals of a testee in a current brain working state in real time, transmitting stimulation to the testee and marking the stimulated electroencephalogram signals;
the upper computer comprises a judgment and analysis module, a stimulation program preset module and an event-related potential generation module, wherein the judgment and analysis module is connected with the stimulation program preset module and judges whether the electroencephalogram signals in the current brain working state accord with stimulation receiving expectation or not after receiving the electroencephalogram signals; the stimulation program presetting module is provided with a stimulation field device matched with the brain working state, and after the stimulation program presetting module receives the electroencephalogram signals analyzed by the judgment and analysis module in the current brain working state, if the electroencephalogram signals are in accordance with stimulation receiving expectation, the stimulation field device presents stimulation to a testee through an electroencephalogram signal collector; the event-related potential generation module is provided with a superposition instrument and an event-related potential generator, the superposition instrument accumulates and averages the intercepted and marked electroencephalogram signals, and the event-related potential generator generates event-related potentials.
The stimulation program presetting module is provided with a stimulation field device matched with the brain working state, if the event-related potential under the stimulation of W in the stimulation field device is expected to be collected, the upper computer judges whether the electroencephalogram signal under the current brain working state accords with the W stimulation receiving expectation or not, so that the stimulation W is not randomly presented relative to a testee, the brain working state is considered, and the collection result of the event-related potential is more accurate.
Referring to fig. 2, the system further comprises:
the electroencephalogram signal amplifier is used for receiving the electroencephalogram signals collected by the electroencephalogram signal collector and then amplifying the electroencephalogram signals;
the electroencephalogram signal filter receives the electroencephalogram signal amplified by the electroencephalogram signal amplifier and filters the electroencephalogram signal;
and the AD converter is used for converting the filtered electroencephalogram analog signals into electroencephalogram digital signals and transmitting the electroencephalogram digital signals to an upper computer.
The following provides a further explanation of the event-related potential acquisition method and system considering the brain operating state in the present application, with reference to the example specifically considering the brain operating state.
When the collection of the event-related potential for distinguishing and memorizing pictures is researched, the concentration of a testee is required, the traditional method is to present picture visual stimulation to the testee after a red cross appears in the center of a screen, whether the brain working state of the current testee is in the concentration state is not considered, for example, whether the head of the testee is stable or not, whether electroencephalogram artifacts appear in the collected electroencephalogram signals or whether the testee blinks or not and the like are not considered, a series of experimental conditions possibly do not accord with the collection of the current event-related potential are not considered, the attention of the testee cannot be concentrated at the moment, the event-related potential in the real concentration state cannot be obtained, and under the method provided by the application, the electroencephalogram signals under the current brain working state of the testee are collected in real time through an electroencephalogram signal collector, then the electroencephalogram signals are amplified through an electroencephalogram signal amplifier, an electroencephalogram signal filter continues to, then, the judgment and analysis module of the upper computer judges whether the electroencephalogram signal in the current brain working state accords with the stimulation receiving expectation or not by a frequency domain analysis method, namely under the current attention-focused brain working state, the electroencephalogram signal is judged to have no motion artifact and no blinking activity of a testee by the frequency domain analysis method, then the electroencephalogram signal wave corresponding to the event-related potential in the attention-focused state is considered to be a beta wave, the base line of the beta wave is determined when the testee thinks that the self is full and the head and the brain are clear, and the power spectrum of the beta wave is obtained by the following steps:
collecting and recording an electroencephalogram signal of the testee through an electroencephalogram signal collector;
SB. performing mental calculation of quick calculation questions in a time period of 3-5 min during acquisition and recording of electroencephalogram signals;
SC. after the subject completes the mental calculation, the frequency domain analysis is carried out to the collected and recorded EEG signal to obtain the real part a and the imaginary part b of the EEG signal frequency spectrum;
SD., obtaining the power spectrum of the brain electrical signal beta wave through the real part a and the imaginary part b of the brain electrical signal frequency spectrum, the formula is:
the power spectrum of the electroencephalogram signal beta wave corresponding to the brain working state with concentrated attention is represented by pu, a represents the real part of an electroencephalogram signal frequency spectrum, and b represents the imaginary part of the electroencephalogram signal frequency spectrum;
when the power spectrum of the beta wave is greater than 80% of the threshold value M, after the stimulation program preset module receives the electroencephalogram signal analyzed by the judgment and analysis module in the current brain working state, accords with the expectation of stimulus reception, the stimulus field device presents picture visual stimulus to the testee through the electroencephalogram signal collector, then intercepting the marked electroencephalogram signals by a superposition instrument, accumulating and averaging to generate event-related potentials, because the attention of the person is fluctuated according to the psychological common knowledge, the person can hardly or not focus for a long time, the traditional mode of randomly presenting the stimulation is likely to present the stimulation when the attention of the testee is not focused, such as shaking or blinking of the head, so the collected event-related potential result is not the event-related potential in the real attention focusing state, the invention ensures that the obtained event-related potential is the event-related potential in the real attention-focusing state.
When the brain working state is a meditation state, the corresponding electroencephalogram wave is an alpha wave, and the traditional method cannot determine whether the collected event-related potential is in the meditation state or not, the method provided by the invention firstly collects electroencephalogram signals of a testee in the current brain working state in real time through an electroencephalogram signal collector, then amplifies the electroencephalogram signals through an electroencephalogram signal amplifier, then continuously filters the electroencephalogram signals, and then a judgment and analysis module of an upper computer judges whether the electroencephalogram signals in the current brain working state accord with stimulation receiving expectation or not through a frequency domain analysis method, namely under the current brain working state of the meditation state, whether the electroencephalogram signals alpha wave accord with the stimulation receiving expectation or not is judged through the frequency domain analysis method, firstly, an alpha wave base line of the testee is determined, and further through the following steps, a power spectrum of the alpha wave is obtained:
collecting and recording an electroencephalogram signal of the testee through an electroencephalogram signal collector;
SB. performing mental calculation of quick calculation questions in a time period of 30 s-1 min during acquisition and recording of electroencephalogram signals by a subject;
SC. after the subject completes the mental calculation, the frequency domain analysis is carried out to the collected and recorded EEG signal to obtain the real part a and the imaginary part b of the EEG signal frequency spectrum;
SD., obtaining the power spectrum of the EEG signal alpha wave through the real part a and the imaginary part b of the EEG signal frequency spectrum, the formula is:
pu represents the power spectrum of the electroencephalogram signal alpha wave corresponding to the meditation state, a represents the real part of the electroencephalogram signal frequency spectrum, and b represents the imaginary part of the electroencephalogram signal frequency spectrum; when the power spectrum of the alpha wave is greater than 80% of the threshold value M, the stimulation program presetting module receives the electroencephalogram signal analyzed by the judgment analysis module under the current brain working state, the electroencephalogram signal accords with stimulation receiving expectation, the stimulation field device presents stimulation to a testee through the electroencephalogram signal collector, the specific schematic diagram is shown in figure 3, the waveform represents the alpha wave of the electroencephalogram signal, the stimulation is presented when the power spectrum of the alpha wave is greater than 80% of the threshold value M, finally, the marked electroencephalogram signal is intercepted through the superposition instrument for accumulation and averaging to generate event related potential, according to psychological knowledge, the size of the power spectrum of the alpha wave can reflect meditation degree, the stimulation is presented when the electroencephalogram signal reaches 80% of the threshold value of the power spectrum of the alpha wave, and the event related potential under the meditation state is.
The same or similar reference numerals correspond to the same or similar parts;
the positional relationships depicted in the drawings are for illustrative purposes only and are not to be construed as limiting the present patent;
it should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (10)
1. An event-related potential acquisition method considering brain working state, characterized by comprising at least the following steps:
s1, acquiring electroencephalogram signals of a testee in a current brain working state in real time through an electroencephalogram signal collector;
s2, transmitting the electroencephalogram signals to an upper computer in real time for analysis;
s3, judging whether the electroencephalogram signals accord with stimulation receiving expectation or not through the upper computer, if so, presenting stimulation to the testee through the upper computer, and marking the electroencephalogram signals corresponding to the stimulation; otherwise, not processing;
and S4, intercepting the marked electroencephalogram signals, and accumulating and averaging to obtain event-related potentials.
2. The method for acquiring event-related potentials considering brain working conditions according to claim 1, wherein the electroencephalogram signal collector in step S1 is a scalp electroencephalogram electrode, and the number of lead of the scalp electroencephalogram electrode is at least 1.
3. The method for acquiring event-related potentials in consideration of brain operating states of claim 2, further comprising, before step S2 and after step S1: and sequentially amplifying, filtering and AD converting the electroencephalogram signals.
4. The method for acquiring event-related potentials according to claim 3, wherein the upper computer performs analysis in step S2 by using one or any combination of frequency domain analysis, time domain analysis, wavelet transformation, artificial neural network analysis and nonlinear dynamics analysis.
5. The method for acquiring event-related potentials considering brain working states of claim 4, wherein the criterion of the electroencephalogram signals meeting the stimulation receiving expectation in the step S3 is as follows: the power spectrum of the electroencephalogram signal wave is larger than N% of the power spectrum threshold value M, and N is an empirical value.
6. The method for acquiring event-related potentials according to claim 5, wherein the stimulus presented to the subject by the upper computer in step S3 comprises one or any combination of auditory stimulus, visual stimulus and tactile stimulus.
7. The method for acquiring event-related potential considering brain working state according to claim 5, wherein the power spectrum of the electroencephalogram signal wave corresponding to the current brain working state is obtained on the basis of the measurement of the electroencephalogram baseline, and the process of measuring the electroencephalogram baseline and obtaining the power spectrum of the electroencephalogram signal wave is as follows:
collecting and recording an electroencephalogram signal of the testee through an electroencephalogram signal collector;
SB. performing mental calculation of quick calculation questions in the time period of t 1-t 2 during the process of acquiring and recording electroencephalogram signals by a test person;
SC. after the subject completes the mental calculation, the frequency domain analysis is carried out to the collected and recorded EEG signal to obtain the real part a and the imaginary part b of the EEG signal frequency spectrum;
SD., obtaining the power spectrum of the EEG signal wave through the real part a and the imaginary part b of the EEG signal frequency spectrum, the formula is:
the pu represents the power spectrum of the electroencephalogram signal wave corresponding to the current brain working state, a represents the real part of the electroencephalogram signal spectrum, and b represents the imaginary part of the electroencephalogram signal spectrum.
8. The method for acquiring event-related potential considering brain working state according to claim 5, wherein the step of intercepting the labeled electroencephalogram signal and accumulating and averaging to obtain event-related potential in step S4 includes:
s41, recording the number N of stimuli presented to a testee by the upper computer;
s42, marking the electroencephalogram signal after the ith stimulation, and intercepting △ t from the marking of the electroencephalogram signaliSegment D of electroencephalogram signal in time periodiThe number of the electroencephalogram signal segments is N, i is 1, …, N;
s43, accumulating the intercepted signal data of the N electroencephalogram signal segments and then averaging, namely:
wherein E represents an event-related potential, DiRepresenting the electroencephalogram signal segment intercepted after the ith stimulation.
9. An event-related potential acquisition system considering a brain operating state, the system being configured to implement the event-related potential acquisition method considering a brain operating state according to claim 1, comprising:
the electroencephalogram signal collector is used for collecting electroencephalogram signals of a testee in a current brain working state in real time, transmitting stimulation to the testee and marking the stimulated electroencephalogram signals;
the upper computer comprises a judgment and analysis module, a stimulation program preset module and an event-related potential generation module, wherein the judgment and analysis module is connected with the stimulation program preset module and judges whether the electroencephalogram signals in the current brain working state accord with stimulation receiving expectation or not after receiving the electroencephalogram signals;
the stimulation program presetting module is provided with a stimulation field device matched with the brain working state, and after the stimulation program presetting module receives the electroencephalogram signals analyzed by the judgment and analysis module in the current brain working state, if the electroencephalogram signals are in accordance with stimulation receiving expectation, the stimulation field device presents stimulation to a testee through an electroencephalogram signal collector;
the event-related potential generation module is provided with a superposition instrument and an event-related potential generator, the superposition instrument carries out accumulation averaging on the intercepted and marked electroencephalogram signals, and the event-related potential generator generates event-related potentials.
10. The system for acquiring event-related potentials in consideration of brain electrical operating conditions of claim 9, further comprising:
the electroencephalogram signal amplifier is used for receiving the electroencephalogram signals collected by the electroencephalogram signal collector and then amplifying the electroencephalogram signals;
the electroencephalogram signal filter receives the electroencephalogram signal amplified by the electroencephalogram signal amplifier and filters the electroencephalogram signal;
and the AD converter is used for converting the filtered electroencephalogram analog signals into electroencephalogram digital signals and transmitting the electroencephalogram digital signals to an upper computer.
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