CN111657912B - System for mechanical pressure stimulation of a subject - Google Patents
System for mechanical pressure stimulation of a subject Download PDFInfo
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- CN111657912B CN111657912B CN202010636420.4A CN202010636420A CN111657912B CN 111657912 B CN111657912 B CN 111657912B CN 202010636420 A CN202010636420 A CN 202010636420A CN 111657912 B CN111657912 B CN 111657912B
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- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
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Abstract
The invention discloses a system for mechanical pressure stimulation of a subject, comprising a pressure stimulator and a controller; at least a portion of the pressure stimulator is located inside a magnetically shielded room for providing mechanical pressure stimulation to a subject inside the magnetically shielded room, wherein the magnetically shielded room has a magnetoencephalogram device inside for acquiring magnetoencephalogram signals from the subject; the controller is in communication with the magnetoencephalography device for receiving magnetoencephalography signals acquired by the magnetoencephalography device and for processing and analyzing the magnetoencephalography signals. The invention can reduce the burden of the testee and improve the stability and reliability of the selection of the stimulation parameters by using the brain magnetic signals to replace the dictation of the testee.
Description
Technical Field
The invention relates to the technical field of biomedical engineering, in particular to a system for performing mechanical pressure stimulation on a testee.
Background
Prosthetic hands currently available on the market that are purchased and used by amputees are typically cosmetic and functional. The functional artificial hand can provide partial hand functions for amputees, including the functions of separating and gathering five fingers, grasping fingers and the like. However, current functional prosthetic hands generally do not provide sensory feedback to the amputee, nor do they indicate to the amputee which finger or fingers are currently being used to perform hand functions as a normal hand. For example, when a functional prosthetic hand is pinching an object with the thumb and forefinger, the amputee cannot know that the thumb and forefinger are being used without seeing this action. In addition, after a large number of stroke patients are hemiplegic, the sensory function of local limbs can be lost, which can aggravate muscular atrophy of the affected side, thereby affecting the motor rehabilitation.
Currently, researchers have also produced hand or local body skin sensations by electrical or mechanical pressure stimulation of amputated or hemiplegic patients. The selection of stimulation parameters, whether by electrical stimulation or mechanical pressure stimulation, is critical. It is common to stimulate a local skin area of a subject by using different stimulation parameters and to rely on the subject's dictation to select the appropriate stimulation parameters. However, relying on dictation to select stimulation parameters not only requires the subject's attention to remain highly focused at the moment, but is also highly susceptible to environmental influences.
Accordingly, those skilled in the art have endeavored to develop a system for mechanical pressure stimulation of a subject that provides the subject with more stable and reliable sensory feedback by improving the manner in which the stimulation parameters are selected.
Disclosure of Invention
In view of the above-mentioned drawbacks of the prior art, the technical problem to be solved by the present invention is how to provide a subject with a more stable and reliable sensory feedback.
To achieve the above object, the present invention provides a system for mechanical pressure stimulation of a subject, comprising a pressure stimulator and a controller; at least a portion of the pressure stimulator is located inside a magnetically shielded room for providing mechanical pressure stimulation to a subject inside the magnetically shielded room, wherein the magnetically shielded room has a magnetoencephalogram device inside for acquiring magnetoencephalogram signals from the subject; the controller is in communication with the magnetoencephalography device for receiving magnetoencephalography signals acquired by the magnetoencephalography device and for processing and analyzing the magnetoencephalography signals.
Further, the pressure stimulator comprises a motor, a pressure contact, and a connection device, wherein the connection device is configured to connect the motor and the pressure contact, the pressure contact is in contact with a local skin of the subject, the local skin comprises a finger and a body local area, the motor is located outside the magnetic shielding chamber and is controlled by the controller to apply mechanical pressure to the pressure contact via the connection device, thereby providing the mechanical pressure stimulation to the local skin of the subject.
Further, the fingers include one or more of a thumb, an index finger, a middle finger, a ring finger, and a little finger; the partial region of the body includes one or more of an upper arm, a forearm, a torso, and a lower limb.
Further, when the controller controls the motor to apply the mechanical pressure to the pressure contact, the controller generates a trigger signal.
Further, the controller further comprises a computing device that performs processing of the brain magnetic signals based at least on the trigger signal.
Further, the processing of the magnetoencephalography signal comprises segmenting, averaging, filtering the magnetoencephalography signal.
Further, the computing device performs an analysis of the brain magnetic signals based on a magnetic resonance image of the brain of the subject and employing an equivalent current dipole model.
Further, the brain magnetic signals include a first brain magnetic signal and a second brain magnetic signal, wherein the first brain magnetic signal includes the brain magnetic signal acquired from the subject when the finger of the subject is stimulated by the mechanical pressure, and the second brain magnetic signal includes the brain magnetic signal acquired from the subject when the partial area of the body of the subject is stimulated by the mechanical pressure.
Further, the computing device further adjusts a stimulation parameter of the pressure stimulator based on the processing and/or analysis of the first and second magnetoencephalo-magnetic signals, thereby adjusting the mechanical pressure stimulation applied to the local skin of the subject.
Further, the stimulation parameters include one or more of a stimulation frequency, a number of turns of the motor, a shape of the press contact, and a contact area of the press contact with the subject.
Compared with the prior art, the technical scheme provided by the invention has the advantages that the brain magnetic signals are used for replacing the dictation of the testee, the burden of the testee can be reduced, and the stability and the reliability of the stimulation parameter selection are improved.
Drawings
FIG. 1 is a general block diagram of a mechanical pressure stimulation system and magnetic shielding room of one embodiment of the present invention.
Among them, 100-mechanical pressure stimulation system, 110-pressure stimulator, 111-motor, 112-pressure contact, 113-connection device, 120-controller, 200-magnetic shield room, 210-magnetoencephalogram device, 220-subject.
Detailed Description
The preferred embodiments of the present invention will be described below with reference to the accompanying drawings for clarity and understanding of technical contents. The present invention may be embodied in many different forms of embodiments and the scope of the invention is not limited to the embodiments set forth herein.
In the drawings, structurally identical elements are represented by like reference numerals, and structurally or functionally similar elements are represented by like reference numerals throughout the several views. The size and thickness of each component shown in the drawings are arbitrarily illustrated, and the present invention is not limited to the size and thickness of each component. The thickness of the components may be exaggerated where appropriate in the figures to improve clarity.
Terms described below herein, such as magnetoencephalography device, magnetoencephalography signal, magnetic shield room, localized area of body, etc., should be understood as meaning well known to those skilled in the art.
Fig. 1 is a general block diagram of a mechanical pressure stimulation system 100 and a magnetic shield room 200 of one embodiment of the present invention.
As shown in fig. 1, the mechanical pressure stimulation system 100 may include a pressure stimulator 110 and a controller 120. Wherein the pressure stimulator 110 may comprise a motor 111, a pressure contact 112, and a connection means 113. In one embodiment, a portion of the connection apparatus 113, the magnetoencephalography device 210, and the subject 220 can be located inside the magnetic shielded room 200, and another portion of the connection apparatus 113, the motor 111, and the controller 120 can be located outside the magnetic shielded room 200. In this embodiment, the press contact 112 can be located inside the magnetic shield room 200 and in contact with the local skin of the subject 220. Wherein the topical skin may include fingers, upper arms, forearms, torso, and lower limbs. When mechanically stimulating the skin of a finger or other body part, subject 220 may feel that the skin of the finger or other part is stimulated. In some embodiments, the motor 111 of the pressure stimulator 110 may be controlled by the controller 120 to apply mechanical pressure to the pressure contact 112 via the connection means 113 to provide mechanical pressure stimulation to the local skin of the subject 220.
In one embodiment, the motor 111 may be a stepper motor or other type of motor that may be used to apply mechanical pressure to the pressure contact 112 via the connection device 113. The press-contact 112 may have a particular shape, e.g., circular, square, etc., to contact the local skin of the subject 220. The connection device 113 may be used to provide a connection between the motor 111 and the press-contact 112 to transfer motion from the motor 111 to the press-contact 112.
In one embodiment, the controller 120 may generate the trigger signal when the controller 120 controls the motor 111 to apply mechanical pressure to the pressure contact 112 via the connection means 113, thereby providing mechanical pressure stimulation to the local skin of the subject 220. The controller 120 can receive magnetoencephalography signals from a subject 220 acquired by a magnetoencephalography device 210. The controller 120 may further include a computing device that may process the acquired brain magnetic signals based on the trigger signal. The processing may include segmentation, averaging, filtering, and the like. Wherein the segmenting may include temporally aligning the magnetoencephalo-magnetic signal with the trigger signal and segmenting the magneto-encephalo-magnetic signal with reference to times of the plurality of trigger signals. In one embodiment, the frequency of the mechanical pressure stimulation may be 1Hz, and the magnetoencephalography signal may be divided at 100ms before the trigger signal and 900ms after the trigger signal, or at 150ms before the trigger signal and 850ms after the trigger signal, or at other divisions of a 1000ms time period. In another embodiment, the frequency of the mechanical pressure stimulation may be 2Hz, and the magnetoencephalography signal may be divided 50ms before the trigger signal and 450ms after the trigger signal, or 100ms before the trigger signal and 400ms after the trigger signal, or other division of 500ms time period. In other embodiments, the frequency of the mechanical pressure stimulation may be other values. Averaging and filtering operations may then be performed on the segmented magnetoencephalo-magnetic signals by a computing device to generate processed magneto-magnetic signals. The computing device may also perform an analysis of the processed brain magnetic signals based on the brain magnetic resonance image of subject 220 and employing an equivalent current dipole model to generate a current dipole.
In some embodiments, the brain magnetic signals may include: a first magnetoencephalography signal acquired from subject 220 when a finger of subject 220 is stimulated by mechanical pressure; and a second magnetoencephalography signal acquired from subject 220 when a localized skin region of the body of subject 220 is stimulated by mechanical pressure. Accordingly, the processed brain magnetic signals may also include the first processed brain magnetic signals and the second processed brain magnetic signals, and the current dipoles may also include the first current dipole and the second current dipole.
In some embodiments, the first processed brain magnetic signal and/or the first current dipole may be used as a criterion to evaluate the second processed brain magnetic signal and/or the second current dipole. In this embodiment, the first magnetoencephalography signal may be a magnetoencephalography signal acquired from subject 220 when subject 220 is clearly and comfortably experiencing a mechanical pressure stimulus to his finger. In one embodiment, the second processed brain magnetic signal may be evaluated by latency. In another embodiment, the second current dipole may be evaluated by its position, orientation, intensity, etc. When the second processed magnetoencephalography signal and/or the second current dipole do not meet the criteria, the stimulation parameters of pressure stimulator 110 may be adjusted, thereby adjusting the mechanical pressure stimulation applied to the localized skin area of the torso of subject 220.
In other embodiments, the first processed brain magnetic signal and/or the first current dipole, or the second processed brain magnetic signal and/or the second current dipole may also be compared to a pre-stored template. When the first processed magnetoencephalography signal and/or the first current dipole, or the second processed magnetoencephalography signal and/or the second current dipole does not conform to the pre-stored template, the stimulation parameters of pressure stimulator 110 may be adjusted, thereby adjusting the mechanical pressure stimulation applied to the local skin (which may include fingers, body part areas) of subject 220.
In one embodiment, the stimulation parameters can include the stimulation frequency, the number of turns of motor 111, the shape of press-touch piece 112, or the contact area of press-touch piece 112 with subject 220. The stimulation parameter may be determined to be the appropriate stimulation parameter when the second processed brain magnetic signal and/or the second current dipole meets a criterion (e.g., the latency of the second processed brain magnetic signal is within a predetermined range of the latency of the first processed brain magnetic signal, the position, orientation, intensity of the second current dipole is within a predetermined range of the position, orientation, intensity, respectively, of the first current dipole) or meets a pre-stored template (e.g., the latency of the second processed brain magnetic signal is within a predetermined range of the latency of the pre-stored template brain magnetic signal, the position, orientation, intensity of the second current dipole is within a predetermined range of the position, orientation, intensity, respectively, of the pre-stored template current dipole). Similarly, the stimulation parameter may be determined to be the appropriate stimulation parameter when the first processed brain magnetic signal and/or the first current dipole is conformed to the pre-stored template (e.g., the latency period of the first processed brain magnetic signal is within a predetermined range of the latency period of the pre-stored template brain magnetic signal, and the position, orientation, and intensity of the first current dipole is within a predetermined range of the position, orientation, and intensity, respectively, of the pre-stored template current dipole).
The above processing and analysis of brain magnetic signals may be performed by a coordinated open source application, brainstrom, installed on a computing device. The Brainstrom software was developed based on MATLAB at the end of the 1990's, a project originally owned by the university of California, southern los Angeles, Paris
Hospitals and the los alamos national laboratory of new mexico were co-operated and were supported by the National Institutes of Health (NIH) and the french national center for research (CNRS). The first version of the software was released at 2000, incorporated the full graphical user interface in 2004,
the foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.
Claims (9)
1. A system for mechanical pressure stimulation of a subject, comprising a pressure stimulator and a controller; at least a portion of the pressure stimulator is located inside a magnetically shielded room for providing mechanical pressure stimulation to a subject inside the magnetically shielded room, wherein the magnetically shielded room has a magnetoencephalogram device inside for acquiring magnetoencephalogram signals from the subject; the controller is communicated with the magnetoencephalography device and is used for receiving magnetoencephalography signals collected by the magnetoencephalography device and processing and analyzing the magnetoencephalography signals;
wherein the magnetoencephalography signal comprises a first magnetoencephalography signal and a second magnetoencephalography signal, wherein the first magnetoencephalography signal comprises the magnetoencephalography signal acquired from the subject when the finger of the subject is stimulated by the mechanical pressure, and the second magnetoencephalography signal comprises the magnetoencephalography signal acquired from the subject when the partial area of the body of the subject is stimulated by the mechanical pressure;
the controller further comprises a computing device that further adjusts stimulation parameters of the pressure stimulator based on processing and/or analysis of the first and second magnetoencephalo-magnetic signals, thereby adjusting the mechanical pressure stimulation applied to local skin of the subject, the local skin including the finger, body localized area;
the processing and/or analyzing of the first and second brain magnetic signals comprises: processing the first brain magnetic signal to obtain a first processed brain magnetic signal, and processing the second brain magnetic signal to obtain a second processed brain magnetic signal; evaluating the second processed brain magnetic signal using the first processed brain magnetic signal as a criterion, and adjusting the mechanical pressure stimulation applied to the somatic part-area of the subject when the second processed brain magnetic signal does not meet the criterion.
2. The system for mechanical pressure stimulation of a subject of claim 1, wherein the pressure stimulator comprises a motor, a pressure contact, a connection means for connecting the motor and the pressure contact, the pressure contact being in contact with a local skin of the subject, the motor being located outside the magnetically shielded chamber and controlled by the controller to apply mechanical pressure to the pressure contact via the connection means to provide the mechanical pressure stimulation to the local skin of the subject.
3. The system for mechanical pressure stimulation of a subject of claim 2, wherein the fingers comprise one or more of a thumb, an index finger, a middle finger, a ring finger, and a little finger; the partial region of the body includes one or more of an upper arm, a forearm, a torso, and a lower limb.
4. The system for mechanical pressure stimulation of a subject of claim 2, wherein the controller generates a trigger signal when the controller controls the motor to apply the mechanical pressure to the pressure contacts.
5. The system for mechanical pressure stimulation of a subject according to claim 4, wherein the computing device performs processing of the magnetoencephalography signal based at least on the trigger signal.
6. The system for mechanical pressure stimulation of a subject according to claim 5, wherein the processing of the magnetoencephalography signals comprises segmenting, averaging, filtering the magnetoencephalography signals.
7. The system for mechanical pressure stimulation of a subject of claim 5, wherein the computing device performs the analysis of the brain magnetic signals based on a magnetic resonance image of the brain of the subject and employing an equivalent current dipole model.
8. The system for mechanical pressure stimulation of a subject of claim 7, wherein the stimulation parameters comprise one or more of a stimulation frequency, a number of turns of the motor, a shape of the press contact, and a contact area of the press contact with the subject.
9. The system for mechanical pressure stimulation of a subject of claim 1, wherein the processing and/or analysis of the first and second brain magnetic signals further comprises: comparing the first or second processed brain magnetic signals to a pre-stored template, and adjusting the mechanical pressure stimulation applied to the finger and/or the somatic part region of the subject when the first or second processed brain magnetic signals do not conform to the pre-stored template.
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| CN202010636420.4A CN111657912B (en) | 2020-07-03 | 2020-07-03 | System for mechanical pressure stimulation of a subject |
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| CN202010636420.4A CN111657912B (en) | 2020-07-03 | 2020-07-03 | System for mechanical pressure stimulation of a subject |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9402558B2 (en) * | 2007-04-05 | 2016-08-02 | New York University | System and method for pain detection and computation of a pain quantification index |
| JP5705223B2 (en) * | 2009-08-26 | 2015-04-22 | カンザス大学 | System and method for stimulating mechanosensory nerve endings |
| DE102010016404A1 (en) * | 2010-04-12 | 2012-12-27 | Forschungszentrum Jülich GmbH | Apparatus and method for conditioned desynchronizing non-invasive stimulation |
| WO2011156287A2 (en) * | 2010-06-07 | 2011-12-15 | Medtronic, Inc. | Selective termination of stimulation to deliver post-stimulation therapeutic effect |
| JP2014003731A (en) * | 2012-06-15 | 2014-01-09 | Canon Inc | Drive unit of vibration type actuator and medical system using the same |
| US9446235B2 (en) * | 2013-03-14 | 2016-09-20 | Medtronic, Inc. | Low frequency electrical stimulation therapy for pelvic floor disorders |
| CN104921902B (en) * | 2014-03-17 | 2017-11-24 | 香港理工大学 | A kind of rehabilitation system of combination perceptional function and mechanical assistance |
| DE102015101823A1 (en) * | 2015-02-09 | 2016-08-11 | Forschungszentrum Jülich GmbH | Apparatus and method for calibrating a non-invasive mechanical tactile and / or thermal neurostimulation |
| CN104825256B (en) * | 2015-04-30 | 2017-05-31 | 南京信息工程大学 | A kind of artificial limb system with perceptible feedback function |
| EP3456305A4 (en) * | 2016-05-13 | 2020-01-08 | Keio University | Biometric information processing device, biometric information processing method and program |
| WO2020102520A1 (en) * | 2018-11-14 | 2020-05-22 | Board Of Regents Of The University Of Nebraska | Tactile stimulation device |
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