CN111616368A - Composition with constipation relieving function and preparation method thereof - Google Patents
Composition with constipation relieving function and preparation method thereof Download PDFInfo
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- 206010010774 Constipation Diseases 0.000 title claims abstract description 36
- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 35
- 241000193749 Bacillus coagulans Species 0.000 claims abstract description 16
- 229940054340 bacillus coagulans Drugs 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 11
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 10
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 10
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 10
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 claims abstract description 9
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 claims abstract description 9
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims abstract description 9
- 150000003271 galactooligosaccharides Chemical class 0.000 claims abstract description 9
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 claims abstract description 9
- 239000002994 raw material Substances 0.000 claims description 45
- 238000002156 mixing Methods 0.000 claims description 9
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 235000018290 Musa x paradisiaca Nutrition 0.000 claims description 7
- 238000005070 sampling Methods 0.000 claims description 7
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- 238000007689 inspection Methods 0.000 claims description 6
- 238000004806 packaging method and process Methods 0.000 claims description 4
- WVXRAFOPTSTNLL-NKWVEPMBSA-N 2',3'-dideoxyadenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1CC[C@@H](CO)O1 WVXRAFOPTSTNLL-NKWVEPMBSA-N 0.000 claims description 2
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 2
- 240000009088 Fragaria x ananassa Species 0.000 claims description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 2
- 240000003394 Malpighia glabra Species 0.000 claims description 2
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- 240000001717 Vaccinium macrocarpon Species 0.000 claims description 2
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 claims description 2
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 claims description 2
- 235000004634 cranberry Nutrition 0.000 claims description 2
- 238000000855 fermentation Methods 0.000 abstract description 13
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- 241000186000 Bifidobacterium Species 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
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- 239000001888 Peptone Substances 0.000 description 2
- 108010080698 Peptones Proteins 0.000 description 2
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- 206010000496 acne Diseases 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
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- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
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- 206010051244 Dyschezia Diseases 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
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- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
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- 230000004888 barrier function Effects 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 229940099352 cholate Drugs 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 230000000112 colonic effect Effects 0.000 description 1
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- 230000001079 digestive effect Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
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- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 230000036541 health Effects 0.000 description 1
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- 238000007619 statistical method Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/148—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention discloses a composition with a constipation relieving function and a preparation method thereof, which relate to the technical field of intestinal health care and comprise the following components: bacillus coagulans BC99 powder, xylo-oligosaccharide, stachyose, galacto-oligosaccharide, fruit powder and maltodextrin; the composition with the function of relieving constipation provided by the invention can obviously increase defecation times, improve defecation conditions and promote intestinal health of a human body; the preparation method of the composition with the function of relieving constipation, provided by the invention, is simple in process, free of fermentation and suitable for industrial production.
Description
Technical Field
The invention relates to the technical field of intestinal health care, in particular to a composition with a function of relieving constipation and a preparation method thereof.
Background
With the improvement of living standard and the acceleration of life rhythm, more and more modern people suffer from constipation due to high-fat and high-sugar eating habits and bad living habits such as long-time sitting and lack of exercise. It is a common clinical gastrointestinal disease, and is mainly manifested by symptoms of unsmooth defecation, difficult defecation, dry stool, abdominal non-fixed and the like. Constipation is not only harmful because it may cause skin roughness, acne, chloasma, pimples, etc., but also is often associated with diseases of digestive, respiratory, neurological, cardiovascular, etc. systems. Meanwhile, constipation can cause psychological burden, anxiety is caused, and the life quality is greatly reduced. Treatment with laxative drugs, while increasing frequency of bowel movements, can lead to laxative bowel disease, colonic melanosis, and electrolyte disturbance.
Probiotics is a kind of active microorganisms beneficial to a host, and is a general term for active beneficial microorganisms which are planted in the intestinal tract and the reproductive system of a human body and can produce exact health efficacy so as to improve the microbial ecological balance of the host and play beneficial roles. Can regulate the balance of intestinal flora, improve the barrier function of gastrointestinal tract, treat intestinal diseases such as constipation and diarrhea, and improve the immunity of human body. Generally, probiotics include lactobacillus, bifidobacterium and the like, and bacillus coagulans is taken as a new generation of probiotics, has better gastric acid and cholate tolerance, high survival rate through gastrointestinal tracts, easy culture and storage and the like besides the functions of traditional probiotics.
The prior patent (CN103893214B) discloses a method for improving constipation by producing probiotic viable bacteria powder through whole oat solid-state mixed bacteria fermentation, but the preparation process is complicated, the fermentation time is long, and the adopted probiotics are lactobacillus and bifidobacterium which are difficult to store and have poor intestinal tolerance.
Disclosure of Invention
In order to solve the technical problems, the invention provides a composition with a constipation relieving function and a preparation method thereof, which can obviously increase defecation times, improve defecation conditions and promote intestinal health of a human body.
The technical scheme adopted by the invention is as follows:
a composition for relieving constipation comprises the following components: bacillus coagulans BC99 powder, xylo-oligosaccharide, stachyose, galacto-oligosaccharide, fruit powder and maltodextrin.
The further scheme of the scheme is that the proportion of each component is as follows according to the mass percentage:
the further scheme of the scheme is that the proportion of each component is as follows according to the mass percentage:
the further scheme of the scheme is that the viable count of the bacillus coagulans BC99 bacterial powder is 20-50 hundred million CFU/g.
In a further scheme of the scheme, the fruit powder is selected from one or more of cranberry powder, acerola powder, orange powder, strawberry powder and banana powder.
In another aspect, the present invention also provides a method for preparing a composition for relieving constipation, comprising the steps of:
selecting raw materials: selecting raw materials of each component which meet the national standard, have the water content of less than or equal to 5 percent and have the mesh number of more than or equal to 100 meshes;
and (4) checking: transferring the raw materials of each component into a 30 ten thousand grade clean area, and carrying out sampling inspection;
sieving and batching: after the raw materials are qualified, respectively sieving the raw materials with a 100-mesh sieve, and weighing the raw materials according to the mass ratio;
mixing: mixing the raw materials of each component for 30-60 minutes to obtain the composition with the function of relieving constipation.
The further scheme of the scheme is that the method further comprises the following steps: packaging, and subpackaging the prepared composition into 2g strips for packaging and boxing.
Compared with the prior art, the technical scheme of the invention has the following advantages and beneficial effects:
the composition with the function of relieving constipation and the preparation method thereof provided by the invention comprise the following components: bacillus coagulans BC99 powder, xylo-oligosaccharide, stachyose, galacto-oligosaccharide, fruit powder and maltodextrin; the composition with the function of relieving constipation provided by the invention can obviously increase defecation times, improve defecation conditions and promote intestinal health of a human body; the preparation method of the composition with the function of relieving constipation, provided by the invention, is simple in process, free of fermentation and suitable for industrial production.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It is noted that the terms "comprises" and "comprising," and any variations thereof, in the description and claims of this invention, are intended to cover a non-exclusive inclusion, such that a process, method, apparatus, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
The Bacillus coagulans (Bacillus coagulans) BC99 used in the following examples has a preservation number of CGMCC No.19487, a preservation date of 3 and 18 days in 2020, a preservation unit of China general microbiological culture Collection center, and a preservation address of No. 3 of Xilu 1 Beijing north township area of the Korean district in Beijing.
The materials and methods used in the following examples are, unless otherwise specified, conventional in the art.
Example 1
Preparation of Bacillus coagulans BC99 powder
Activating Bacillus coagulans BC99 as fermentation strain with secondary seed culture medium, inoculating into fermentation culture medium, culturing, centrifuging at 10000rpm, separating to obtain dry powder with viable count of 1 × 1011cfu/g。
The seed culture medium comprises the following components: 1000mL of purified water, 10g of peptone, 5g of yeast powder, 5g of glucose and 2g of dipotassium hydrogen phosphate, and the pH value is adjusted to be 6.5-7.0.
The fermentation medium comprises the following components: 10g of peptone, 3g of beef extract, 5g of sodium chloride, 5g of glucose and 1L of water, and the pH value is adjusted to 7.0.
The strain activation is shake flask culture: inoculating the fermentation strain into a shake flask filled with a seed culture medium, and performing shake culture for 20 h. The liquid loading of the primary and secondary seed culture shake flasks are 20ml/250ml and 50ml/500ml triangular flasks, respectively. The culture conditions are as follows: the shaking speed is 200r/min, and the temperature is 37 ℃.
The fermentation culture is fermentation tank culture, the liquid loading amount of the fermentation tank is 70%, the cultured seeds are inoculated into the fermentation tank for fermentation, the culture condition is that the stirring speed is 150r/min, the ventilation volume is 0.7vvm, the temperature is 35 ℃, and the culture time is 36-48 h.
The operating conditions of the spray drying process are as follows: the air inlet temperature is 210 ℃, and the air outlet temperature is 100 ℃.
Example 2
Selecting raw materials of each component according to the conditions that the water content is less than or equal to 5 percent and the mesh number is more than 100 meshes, transferring the raw materials of each component into a 30 ten thousand grade clean area, sampling and inspecting, sieving by a 100-mesh sieve after passing inspection, weighing the raw materials according to the mass ratio shown in the table 1, and mixing the raw materials of each component for 30-60 minutes to obtain the composition with the function of relieving constipation.
Table 1 mass ratio of each component raw material
| Name of raw materials | Dosage of |
| Bacillus coagulans BC99 powder | 1.00％ |
| Xylo-oligosaccharide | 20.00％ |
| Stachyose | 50.00％ |
| Galacto-oligosaccharides | 10.00％ |
| Banana fruit powder | 5.00％ |
| Maltodextrin | 14.00％ |
Example 3
Selecting raw materials of each component according to the conditions that the water content is less than or equal to 5 percent and the mesh number is more than 100 meshes, transferring the raw materials of each component into a 30 ten thousand grade clean area, sampling and inspecting, sieving by a 100-mesh sieve after passing inspection, weighing the raw materials according to the mass ratio shown in the table 2, and mixing the raw materials of each component for 30-60 minutes to obtain the composition with the function of relieving constipation.
Table 2 mass ratio of each component raw material
| Name of raw materials | Dosage of |
| Bacillus coagulans BC99 powder | 2.00％ |
| Xylo-oligosaccharide | 15.00％ |
| Stachyose | 40.00％ |
| Galacto-oligosaccharides | 20.00％ |
| Banana fruit powder | 6.00％ |
| Maltodextrin | 17.00％ |
Example 4
Selecting raw materials of each component according to the conditions that the water content is less than or equal to 5 percent and the mesh number is more than 100 meshes, transferring the raw materials of each component into a 30 ten thousand grade clean area, sampling and inspecting, sieving by a 100-mesh sieve after passing inspection, weighing the raw materials according to the mass ratio shown in the table 3, and mixing the raw materials of each component for 30-60 minutes to obtain the composition with the function of relieving constipation.
TABLE 3 Mass ratios of the raw materials of the components
| Name of raw materials | Dosage of |
| Bacillus coagulans BC99 powder | 3.00％ |
| Xylo-oligosaccharide | 15.00％ |
| Stachyose | 25.00％ |
| Galacto-oligosaccharides | 30.00％ |
| Banana fruit powder | 7.00％ |
| Maltodextrin | 20.00％ |
Example 5
Selecting raw materials of each component according to the conditions that the water content is less than or equal to 5 percent and the mesh number is more than 100 meshes, transferring the raw materials of each component into a 30 ten thousand grade clean area, sampling and inspecting, sieving by a 100-mesh sieve after the raw materials are qualified, weighing the raw materials according to the mass ratio shown in the table 4, and mixing the raw materials of each component for 30-60 minutes to obtain the composition with the function of relieving constipation.
TABLE 4 Mass ratios of the raw materials of the components
| Name of raw materials | Dosage of |
| Bacillus coagulans BC99 powder | 3.00％ |
| Xylo-oligosaccharide | 25.00％ |
| Stachyose | 25.00％ |
| Galacto-oligosaccharides | 30.00％ |
| Banana fruit powder | 8.00％ |
| Maltodextrin | 9.00％ |
Example 6
Selecting raw materials of each component according to the conditions that the water content is less than or equal to 5 percent and the mesh number is more than 100 meshes, transferring the raw materials of each component into a 30 ten thousand grade clean area, sampling and inspecting, sieving by a 100-mesh sieve after passing inspection, weighing the raw materials according to the mass ratio shown in the table 5, and mixing the raw materials of each component for 30-60 minutes to obtain the composition with the function of relieving constipation.
TABLE 5 Mass ratios of the raw materials of the components
| Name of raw materials | Dosage of |
| Bacillus coagulans BC99 powder | 5.00％ |
| Xylo-oligosaccharide | 25.00％ |
| Stachyose | 15.00％ |
| Galacto-oligosaccharides | 30.00％ |
| Banana fruit powder | 10.00％ |
| Maltodextrin | 15.00％ |
Example 7
Human body test eating test
The volunteer subjects with constipation were selected, and the patients with recent dyschezia due to the disease, pregnant women, patients under treatment with other accompanying diseases, and patients taking the items related to the tested functions for a short period were excluded, and the total of 120 persons were included, wherein 30 persons in the control group, 30 persons in the sample group of example 4, 30 persons in the sample group of example 5, and 30 persons in the sample group of example 6 were included. The sample is 2g of the functional composition for relieving constipation, and the control group is maltodextrin with equal mass, which is taken once a day and 2g each time. Before the subject took the test sample (14d) and during the test period (14d), the number and condition of defecation per day were recorded, and the subject was classified into I to IV according to the degree of difficulty in defecation (abdominal pain, burning sensation in anus, feeling of falling down, discomfort, frequent defecation but difficulty in defecation and small amount). The collected amount was subjected to statistical analysis, and the results are shown in Table 6.
TABLE 6 results of human feeding trials
Note: p is less than 0.05 after the test feeding compared with before the test feeding, and P is less than 0.05 when # is compared with the control group.
As can be seen from table 6, when the experimental groups of examples 5 and 6 were fed, the number of stools was significantly increased and the stool condition was significantly improved in the experimental groups of examples 5 and 6, compared to the control group; the example 5 sample contains a lower amount of probiotic bacteria, and is therefore more preferred to be example 5, without significant differences in the improvement effect.
The composition for relieving constipation provided by the embodiment can effectively improve the immunity of a human body, regulate the intestinal flora and relieve constipation; the preparation method is simple, the processing is convenient, the shelf life is long, and the industrial production is convenient.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (7)
1. A composition with a function of relieving constipation is characterized by comprising the following components: bacillus coagulans BC99 powder, xylo-oligosaccharide, stachyose, galacto-oligosaccharide, fruit powder and maltodextrin.
2. The composition for relieving constipation according to claim 1, wherein the ratio of each component is as follows, calculated by mass percent:
3. the composition for relieving constipation according to claim 2, wherein the ratio of each component is as follows by mass percent:
4. the composition for relieving constipation according to any one of claims 1 to 3, wherein the Bacillus coagulans BC99 has a viable count of 20 to 50 billion CFU/g.
5. The composition for relieving constipation function according to any one of claims 1 to 3, wherein the fruit powder is selected from one or more of cranberry powder, acerola powder, orange powder, strawberry powder and banana powder.
6. A method for preparing the composition for relieving constipation function according to any one of claims 1 to 5, comprising the steps of:
selecting raw materials, namely selecting raw materials of various components which meet the national standard, have the water content of less than or equal to 5 percent and have the mesh number of more than or equal to 100 meshes;
and (4) checking: transferring the raw materials of each component into a 30 ten thousand grade clean area, and carrying out sampling inspection;
sieving and batching: after the raw materials are qualified, respectively sieving the raw materials with a 100-mesh sieve, and weighing the raw materials according to the mass ratio;
mixing: mixing the raw materials of each component for 30-60 minutes to obtain the composition with the function of relieving constipation.
7. The method for preparing a composition for relieving constipation according to claim 6, which further comprises the steps of: packaging, and subpackaging the prepared composition into 2g strips for packaging and boxing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010469179.0A CN111616368A (en) | 2020-05-28 | 2020-05-28 | Composition with constipation relieving function and preparation method thereof |
Applications Claiming Priority (1)
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