CN111569467A

CN111569467A - Extraction system of urine physiologically active substance and use method thereof

Info

Publication number: CN111569467A
Application number: CN202010419785.1A
Authority: CN
Inventors: 杜锦治; 邱大乾; 侯廷钺
Original assignee: Taiwan Polyamine Co ltd
Current assignee: Taiwan Polyamine Co ltd
Priority date: 2020-05-18
Filing date: 2020-05-18
Publication date: 2020-08-25

Abstract

An extraction system of urine physiologically active substances and a use method thereof, wherein the extraction system comprises a urinal, an extraction device and a flushing device. The extraction device comprises an extraction barrel and an extraction material, wherein the extraction barrel is provided with a containing groove, and the extraction material is arranged in the containing groove. The flush device is configured to supply a flush water and direct a flow of water into the extraction device. Therefore, the extraction material is only required to be collected and replaced, the processing work of releasing and purifying the physiologically active substances can be carried out, the blocking situation of the extraction device can be avoided, and the extraction amount of the physiologically active substances is increased.

Description

Extraction system of urine physiologically active substance and use method thereof

Technical Field

The invention relates to a urine treatment system, in particular to an extraction system of urine physiologically active substances and a method for extracting the urine physiologically active substances.

Background

Human urine can extract various physiologically active substances, and the physiologically active substances can be further refined into human-derived medicines which are beneficial to human bodies, have low rejection and no side effect. However, the extraction of these valuable physiologically active substances requires the use of a large amount of human urine as a raw material.

CN105817053A discloses an extraction device for physiologically active substances in urine, which is directly placed on the urine funnel or urine groove of a toilet, and an extraction material in the device is used to adsorb the physiologically active substances in urine, and the physiologically active substances adsorbed on the extraction material can be obtained by the treatment of desorption and purification.

However, the above prior art has a disadvantage in that urine contains various crystalline substances and amorphous substances, which may be precipitated due to a change in pH of urine, abnormal metabolism or lack of substances inhibiting crystal precipitation in a saturated state. When urine is input into the urine extraction device, the urine is not continuously input but intermittently input, so that part of urine and sediments are remained in the extraction material in the device and accumulated to block the circulation of the subsequently input urine, so that the urine is accumulated on the surface of the extraction material, the urine is influenced by temperature and pH value, undesired sediments are generated, and the sediments are accumulated on the surface layer of the extraction material, so that the circulation of the urine is further deteriorated, and the function of the extraction device is lost.

Although there have been attempts to add preservatives to the extraction material or to inhibit bacterial growth to prevent clogging, they do not improve the problem of crystal precipitation; in addition, the problem of clogging of the extraction apparatus cannot be improved by increasing the particle size of the extraction material. Therefore, how to solve the above problems and provide an environmentally friendly, beautiful, economical and efficient way to extract physiologically active substances from urine is the main object of the present invention.

Disclosure of Invention

The invention aims to provide an extraction system of urine physiologically active substances and a use method thereof, so as to solve at least one problem.

In order to solve the above problems in the prior art, the present invention provides an extraction system for urine bioactive substances, which comprises a urinal, an extraction device and a flushing device. The extraction device comprises an extraction barrel and an extraction material. The extraction barrel is provided with a containing groove, and an inlet and an outlet which are positioned at two opposite sides of the containing groove. The extraction material is arranged in the containing groove and is positioned above the outlet. The flush device is configured to supply a flush water and direct a flow of water into the inlet.

In one embodiment, each flush from the flush device is sufficient to completely cover the upper surface of the extraction material with water entering the inlet.

In one embodiment, the flushing time of each supply of the flushing device is 10 seconds to 10 minutes, including 10 seconds to 50 seconds, 10 seconds to 40 seconds, 20 seconds to 30 seconds, 1 minute to 10 minutes, or 2 minutes to 6 minutes.

In one embodiment, the volume of water entering the inlet is 1 to 5 times the volume of the extraction material, including 1, 1.5, 2, 2.2, 2.5, 3, 3.1, 3.5, 4, 4.5, 4.7, or 5 times. In another embodiment, the volume of water entering the inlet is 3 to 5 times the volume of the extraction material, for example: greater than 3 times to no more than 5 times, including 3.1 times, 3.5 times, 4 times, 4.5 times, 4.7 times, or 5 times.

In one embodiment, the flushing device includes a drainage tube, and an opening at one end of the drainage tube is connected to the flushing port of the urinal, and an opening at the other end is located above the inlet.

In one embodiment, the flush apparatus includes a timing controller configured to control the flush interval time.

In one embodiment, the extraction device further comprises a filter layer disposed above the inlet.

In one embodiment, the extraction device further comprises a baffle configured to direct urine flow into the inlet.

In one embodiment, the extraction materials are each selected from at least one of the group consisting of ion exchange resins, polymer fibers, chitosan, and combinations thereof.

In one embodiment, the physiologically active substance comprises urokinase, a urotrypsin inhibitor, macrophage colony stimulating factor, or a combination thereof.

The invention also provides a method for extracting urine physiologically active substances, which comprises the following steps: providing an extraction system of the urine physiologically active substance; enabling urine to flow into the extraction barrel from the inlet of the extraction device, and enabling the urine to be discharged out of the extraction barrel from the outlet after the extraction material adsorbs physiologically active substances in the urine through the extraction material in the accommodating groove; starting the flushing device to supply flushing water, so that water flow enters the inlet, passes through the extraction material in the accommodating groove and is discharged out of the extraction barrel through the outlet; recovering the extraction material from the extraction unit; and treating the extraction material with a desorbent to obtain a solution containing the physiologically active substance.

In one embodiment, the water entering the inlet is sufficient to completely cover the upper surface of the extraction material before exiting the extraction vat.

In one embodiment, the desorbent includes at least one of an alkaline ammonium chloride solution, an ammonium sulfate solution, and a phosphate buffer.

The extraction system of the present invention is not limited to the toilet form, and can be applied to the design of modern toilets, for example, the extraction device is directly placed on the urine bucket or urine groove of the toilet, so that the extraction material in the extraction device directly adsorbs the physiologically active substances in the urine, and then the flushing device of the prior toilet equipment is utilized to flush the water into the extraction device, so as to wash the urine and sediments remained in the device, and keep the device smooth and clean.

The extraction system can discharge urine remained in the extraction material, and simultaneously, the extraction material which is close to the body temperature due to the passing of the urine is quickly cooled to the water temperature, so that the urine remained in the extraction material is prevented from generating crystal precipitation due to the influence of the external environment, and the flowing of liquid in the extraction material is prevented; furthermore, the extraction system of the invention can also be washed out directly by the water pressure of the flushing water if an existing precipitate has formed in the extraction material.

The extraction system of the invention eliminates the blockage of the extraction device caused by the sediment, prolongs the service life of the extraction device, increases the extraction amount of the physiologically active substances, and can avoid urine accumulation in a urinal after flushing the urine and the sediment in the extraction device so as to keep the toilet free from peculiar smell, keep the sanitation and easy maintenance and achieve the purposes of environmental protection, economy and high efficiency.

Drawings

FIG. 1 shows a schematic diagram of one embodiment of an extraction system of the present invention;

FIG. 2 shows an exploded view of one embodiment of an extraction apparatus in the extraction system of the present invention; and

FIG. 3 is a schematic diagram of an embodiment of an extraction system according to the present invention.

Wherein the reference numerals are as follows:

1. 1a extraction device

11 Filter layer

12 baffle

13 first extraction barrel

131 first accommodation groove

132 first inlet

133 first outlet

14 first extraction material

15 second extraction barrel

151 second receiving groove

152 second inlet

153 second outlet

16 second extraction material

17 first sieve

18 second sieve

2 flushing device

21 drainage tube

22 timing controller

23 Water source switch

3 urinal

3a urine collecting groove

31 flushing port

32 discharge port.

Detailed Description

The embodiments of the present invention are described below with reference to specific embodiments, and those skilled in the art can easily understand the advantages and effects of the present invention from the disclosure of the present specification. The invention is capable of other and different embodiments and its several details are capable of modification in various other respects, all without departing from the spirit and scope of the present disclosure.

The structure, proportion, size and the like shown in the attached drawings are only used for matching with the content disclosed in the specification, so that the skilled in the art can understand and read the invention, and the limitation condition of the invention which can be implemented is not used for limiting the invention, so the essence of the technology is not existed, and any structural modification, proportion relation change or size adjustment still falls within the scope covered by the technical content disclosed in the invention without affecting the effect and the purpose which can be achieved by the invention. In addition, the terms "upper", "lower", "top", "first", "second" and "a" as used in the present specification are for convenience of description only and are not intended to limit the scope of the present invention, and the relative relationship between the terms and the terms is not to be construed as a limitation of the scope of the present invention.

FIG. 1 shows a schematic diagram of an embodiment of an extraction system of the present invention. Referring to fig. 1, the system for extracting physiologically active substances from urine of the present invention includes an extraction device 1, a flushing device 2, and a urinal 3. The extraction device 1 is disposed above a drain port (not shown) of the urinal 3, and has an extraction barrel and an extraction material disposed therein, and in the embodiment, the extraction device 1 further includes a filter layer 11 and a baffle 12. The flushing device 2 comprises a drainage tube 21, and one end opening of the drainage tube 21 is connected with a flushing port 31 of the urinal 3, and the other end opening is positioned above the extraction device 1, so as to guide water flowing out of the flushing port 31 to the extraction device 1.

The number, diameter and length of draft tube 21 are not particularly limited, so long as it is adapted to interface with flush port 31 and provide a flow directing function. In particular, one or more drainage tubes 21 of appropriate length may be used to insert into the outlet just above the urinal 3 to drain water into the extraction device 1. The drainage tube 21 is designed to be detachable, and can be replaced and cleaned at any time.

Urine is guided by the baffle 12 or directly passes through the filter layer 11 to enter the extraction barrel, and is discharged from the extraction barrel after absorbing physiologically active substances in the urine by the extraction material. The flushing device 2 is used for supplying flushing water, when the flushing device 2 is started, water flows out from the flushing port 31, part of the water flows into the extraction device 1 through the drainage tube 21, and urine or sediment remained in the extraction device 1 is cleaned and discharged from the extraction barrel. The completion of the above operation means that the extraction of the physiologically active substance in urine and the cleaning of the extraction device 1 are completed once, and the above operations are repeated after the next user urinates.

The extraction system of the urine physiologically active substance of the present invention may further comprise: an appliance control device configured to control whether the flush device supplies a flush water; and a human body sensing device, such as an infrared sensing device, configured to sense a human body standing in the urinal. In one embodiment, when the human body sensing device senses a human body and exceeds a certain time, the sensing device sends a signal after the user urinates and senses that the human body leaves, and the flushing device is started through the electrical control device to supply flushing.

In one embodiment, the flushing device provides sufficient flushing water each time to completely cover the top surface of the extraction material from the inlet of the extraction device to the outlet of the extraction device. In particular, the area of the upper surface of the extraction material covered by water is related to the water flow rate, flow velocity and extraction material permeability. If the water entering the inlet does not completely cover the upper surface of the extraction material, it means that the water only flows through a part of the extraction material, and the urine remaining in the extraction material cannot be completely cleaned, which causes the formation of sediment to cause urine accumulation, and thus the extraction efficiency of the physiologically active substance is reduced. If a large amount of water flows into the extraction device in a short time, the physiologically active substance adsorbed on the extraction material is washed away by the water and lost, and the extraction efficiency of the physiologically active substance is also reduced.

In one embodiment, the flushing time of each supply of the flushing device is 10 seconds to 10 minutes, such as 10 seconds to 50 seconds, 10 seconds to 40 seconds, 10 seconds to 30 seconds, 10 seconds to 20 seconds, 20 seconds to 50 seconds, 20 seconds to 40 seconds, 20 seconds to 30 seconds, 50 seconds to 10 minutes, 1 minute to 10 minutes, 2 minutes to 8 minutes, 2 minutes to 6 minutes, and 3 minutes to 6 minutes. In another embodiment, the volume of water entering the inlet of the extraction device is 1 to 5 times the volume of the extraction material, such as 1, 1.5, 2, 2.2, 2.5, 3, 3.1, 3.5, 4, 4.5, 4.7, and 5 times. In another embodiment, the volume of water entering the inlet of the extraction device is 3 to 5 times the volume of the extraction material, for example: greater than 3 times to no more than 5 times, including 3.1 times, 3.5 times, 4 times, 4.5 times, 4.7 times, or 5 times.

FIG. 2 shows an exploded view of one embodiment of an extraction apparatus used in the present invention. The extraction apparatus used in the present invention may include a plurality of extraction barrels and extraction materials, for example, referring to fig. 2, the extraction apparatus 1 includes a first extraction barrel 13, a first extraction material 14, a second extraction barrel 15, and a second extraction material 16. The first extraction barrel 13 has a first receiving groove 131, and a first inlet 132 and a first outlet 133 located at opposite sides of the first receiving groove 131. The first extraction material 14 is disposed in the first receiving groove 131 and above the first outlet 133. The second extraction barrel 15 has a second containing groove 151, and a second inlet 152 and a second outlet 153 located at two opposite sides of the second containing groove 151, and the second extraction material 16 is disposed in the second containing groove 151 and above the second outlet 153. The second extraction barrel 15 is disposed above the first extraction barrel 13 such that the second extraction barrel 15 and the first extraction barrel 13 are in liquid communication through the second outlet 153 and the first inlet 132. The sidewall of the lower end of the second extraction barrel 15 is provided with external threads, and the sidewall of the upper end of the first extraction barrel 13 is provided with internal threads, so that the two can be connected through threads. It should be noted that the first extraction barrel 13 and the second extraction barrel 15 are not limited to be connected by a screw, but can be connected by a snap or a latch, for example, and not limited thereto.

In this embodiment, the extraction apparatus 1 further includes: a filter layer 11 and a baffle 12. The filter layer 11 is disposed above the second inlet 152, so that the filter layer 11 and the second extraction barrel 15 are in liquid communication through the second inlet 152, and can filter impurities such as phlegm, toilet paper, cigarette butts and the like to enter the extraction barrel, thereby preventing the extraction device 1 from being blocked by the impurities. The side wall of the lower end of the filter layer 11 is provided with external threads, and the side wall of the upper end of the second extraction barrel 15 is provided with internal threads, so that the filter layer and the second extraction barrel can be connected through threads. Similarly, the filter layer 11 and the second extraction barrel 15 are not limited to be connected by a screw thread, but can be connected by a snap or a latch, for example, and not limited thereto.

In this embodiment, the baffle 12 is disposed along an edge of the filter layer 11 and may direct the flow of urine through the filter layer 11 and into the second inlet 152. The height and length of the baffle 12 are not particularly limited as long as it can provide auxiliary water flow and urine guiding function without interfering with the placement of the extraction device and also without blocking the flow of urine into the inlet of the extraction device.

In one embodiment, the urine flowing into the second extraction barrel 15 through the second inlet 152 passes through the second extraction material 16 in the second containing groove 151 to extract the physiologically active substances in the urine, then the urine flows into the first extraction barrel 13 through the second outlet 153, the physiologically active substances are extracted again by the first extraction material 14 in the first containing groove 131, and the extracted urine is discharged out of the first extraction barrel 13 through the first outlet 133.

In one embodiment, after the extracted urine is discharged, the water flows into the second extraction barrel 15 through the second inlet 152, passes through the second extraction material 16 in the second containing groove 151, and flows into the first extraction barrel 13 through the second outlet 153, wherein the water is enough to completely cover the second extraction material 16; then, the water flows through the first extraction material 14 in the first containing groove 131 to wash the residual urine, and the water is enough to completely cover the first extraction material 14 before being discharged out of the first extraction barrel 13 through the first outlet 133; finally, the remaining urine and water flow are discharged out of the first extraction tub 13 through the first outlet 133.

The first extraction barrel 13 and the second extraction barrel 15 can be made of detergent-resistant and easy-to-maintain material, such as synthetic plastic, such as acryl, glass fiber, or metal, such as stainless steel. The first outlet 133 at the bottom of the first extraction barrel 13 may be designed in a type having a plurality of tooth-shaped drain holes so that the extracted urine and the water for washing the remaining urine can be dispersedly discharged out of the first extraction barrel 13 through the first outlet 133.

The extraction material used in the present invention may be a natural or semi-processed substance, such as anion-cation exchange resin, polyethylene terephthalate (PET) fiber or chitosan (chitosan), which may be placed in the receiving tank of the extraction vat in a single layer or in multiple layers. In the present embodiment, the first extraction material 14 and the second extraction material 16 can be the same or different extraction materials, such as at least one selected from the group consisting of ion exchange resin, polymer fiber, and chitosan. In one embodiment, the anion exchange resin can be dimethylethanolamine anion exchange resin containing ethanolamine as an ion exchange functional group, and the cation exchange resin can be a carboxyl cation exchange resin containing carboxylic acid as an ion exchange functional group.

In this embodiment, the extraction apparatus 1 further includes: a first screen 17 and a second screen 18. A first screen 17 is disposed between the first outlet 133 and the first extraction material 14. The second screen 18 is disposed between the second outlet 153 and the second extraction material 16. The first sieve 17 and the second sieve 18 prevent the loss of the extraction material.

The extraction system of the present invention may optionally comprise a plurality of extraction devices, each having an extraction vat and extraction material disposed therein in fluid communication with each other via a conduit. Therefore, after the urine flows into the containing groove of one of the extracting devices, the urine can flow into the containing groove of the other adjacent extracting device through the pipeline.

In one embodiment, the extraction materials in different extraction devices may be the same or different extraction materials, such as at least one selected from the group consisting of ion exchange resins, polymer fibers, and chitosan.

In one embodiment, urinals suitable for use in the extraction system of the present invention can be of any type, including, for example, vertical urinals, wall-mounted urinals, and trench urinals having a urine collection trough.

In one embodiment, the extraction system of the present invention comprising a plurality of extraction devices is suitable for use in a toilet with a large volume of urine in a trench urinal. For example, the extraction system of the present invention may comprise a first extraction apparatus and a second extraction apparatus or more extraction apparatuses in fluid communication with each other with a conduit; the first extraction device is placed below a discharge port of the groove type urinal, and urine flows into the second extraction device or other extraction devices through a pipeline after being discharged from the discharge port and flowing into the first extraction device; similarly, when the flushing device is activated, water flows out of the flushing port of the small urinal and flows into the first extraction device, then flows into the second extraction device or other extraction devices through the pipeline, and then is discharged into the original discharge system of the toilet. The number of the extraction devices in the extraction system can be increased or decreased according to the actual amount of urine and the actual amount of flushing water.

In one embodiment, the extraction system of the present invention can use extraction devices of different sizes according to the urine volume and the flushing volume of the toilet, thereby increasing the amount and efficiency of extracting physiologically active substances. For example, the extraction device disposed in a trench urinal can be 2 times, 3 times, 4 times, 5 times, 6 times, 7 times, or 8 times the volume of the extraction device disposed in a vertical or wall-mounted urinal.

FIG. 3 is a schematic diagram illustrating an embodiment of an extraction system according to the present invention. Referring to fig. 3, a urine collection tank 3a is installed along the wall at a height of 35 to 50 cm above the urine groove of the groove-type urinal, and an extraction device 1a is installed below the discharge port 32 of the urine collection tank 3 a. In one embodiment, the bottom of the urine collection tank 3a has a slope design such that urine can be discharged from the discharge port 32 of the urine collection tank 3a by being guided by the slope of the bottom of the urine collection tank 3 a. It should be noted that the number of the discharge ports 32 of the urine collecting tank 3a may be more than one according to the requirement, and the extraction device may be disposed below each discharge port.

In the embodiment shown in fig. 3, urine flows through the bottom of the urine collection tank 3a and is discharged from the discharge port 32 of the urine collection tank 3a into the extraction device 1a, and after the physiologically active substance in the urine is adsorbed by the extraction material contained therein, the urine is discharged from the extraction device 1 a; similarly, when the flushing device 2 is activated, the water flows out of the flushing port 31, is discharged from the discharge port 32 of the urine collection tank 3a, then flows into the extraction device 1a, washes the urine or sediment remaining in the extraction device 1a, and then discharges the washed urine or sediment into the original discharge system of the toilet.

The groove type urinal is usually arranged in a toilet with large flow and limited toilet space, so that the equipment is cheap, and the problem of sudden increase of number of people urinating instantly can be solved. In the embodiment, the flushing device 2 of the extraction system of the present invention includes a timing controller 22 and a water source switch 23 configured to control the flushing interval and the flushing amount, so as to greatly save the water supply and keep the toilet clean. For example, the extraction system of the present invention can be applied to a toilet in a school, and the timer controller 22 is set to flush water once in about 40-60 minutes according to the length of the class time, so that after the class time of the sudden increase of the number of urinates, the timer controller 22 of the flush device 2 will control the water switch 23 to be turned on to flush the urine and the sediment remained in the extraction device.

The extraction system of the invention can be used in conjunction with modern toilets, for example, the extraction device can be located in a wall-mounted urinal or below the discharge outlet of a trench urinal. The extraction system of the invention directly adsorbs the physiologically active substances in the urine by the extraction material in the extraction device, the adsorbed urine is discharged into a septic tank of the toilet, the flushing water is supplied by the flushing device, and the water flow is guided into the extraction device, so that the urine and the sediment remained in the device are cleaned, the device is kept smooth and clean, and the redundant water can still be discharged into the original discharge system of the toilet without influencing the adsorption of the physiologically active substances in the extraction material.

The extraction system of the invention does not need to destroy the original equipment and functions of the toilet, improves the extraction efficiency of the physiologically active substances, simultaneously keeps the toilet without peculiar smell, and is easy to maintain sanitation. Generally, the extraction material is collected and replaced once a day, and then the extraction material is sent back to the factory, so that collecting personnel do not need to carry heavy urine, the labor cost and the transportation cost are greatly reduced, the injury probability of the collecting personnel is further reduced, and the urine collection from a toilet in a high building is easier. In addition, the physiologically active substance is directly absorbed by the extraction material, waste urine does not need to be treated in a factory, and the trouble of urine freshness is eliminated, so that the quality of the physiologically active substance is improved, and the aims of environmental protection, economy and high efficiency are fulfilled.

The method for extracting the physiologically active substance in the urine comprises the following steps: firstly, the extraction device is used to extract the physiologically active substance in the urine, for example, the extraction device 1 is used to make the urine flow into the second extraction barrel 15 from the second inlet 152, pass through the second extraction material 16 in the second containing groove 151 and the first extraction material 14 in the first containing groove 131, so that after the physiologically active substance in the urine is extracted by the first extraction material 14 and the second extraction material 16, the extracted urine is discharged out of the first extraction barrel 13 from the first outlet 133; then, the flushing device 2 is activated to supply flushing water, so that the water flow enters the second inlet 152 and flows into the second extraction barrel 15, and passes through the second extraction material 16 in the second containing groove 151 and the first extraction material 14 in the first containing groove 131, and is discharged out of the first extraction barrel 13 from the first outlet 133; then, recovering the first extraction material 14 and the second extraction material 16; thereafter, the first extraction material 14 and the second extraction material 16 are treated with a desorbent to obtain a solution containing the physiologically active substance.

Specifically, the physiologically active substances in urine include Urokinase (UK), urotrypsin inhibitor (UTI), and macrophage colony stimulating factor (M-CSF).

The following describes the embodiment of the present invention for extracting a physiologically active substance from urine by using a specific example of a specific extraction material.

Example 1

An extraction apparatus having first and second extraction barrels is used. Laying anion exchange resin, such as dimethylethanolamine anion exchange resin, in a first extraction barrel of the extraction device; cation exchange resin, such as carboxyl cation exchange resin, is placed in the second extraction barrel of the extraction device. The amount of extraction material in each of the first and second extraction barrels is about 300mL, so the extraction apparatus totals about 600mL of extraction material.

The test site is a public toilet, four urinals are arranged in the public toilet, and the average daily number of people is about 200 to 250. The extraction device is placed in each wall-mounted urinal of a public toilet, drainage tubes are arranged at the water outlets of the two urinals, and the placement time is from 7 am to 6 pm. After the placement is started, the inspection is carried out once per hour, whether the surface layer of the extraction material accumulates urine or water is checked, and the meaning is that the extraction material starts to be blocked, so that the urine or water flow is blocked.

And after the placement is finished, the device is taken back, whether a white substance deposition layer exists on the surface of the extraction material is checked in a laboratory, and the urokinase activity value is measured. Methods for determining urokinase activity values may use techniques known in the art, such as those disclosed in CN 105817053A. The measurement results are shown in table 1 below:

TABLE 1

As is clear from Table 1 above, by providing a suitable water flow, the formation of a white deposit can be significantly avoided, while urine or water accumulation on the surface of the extraction material is avoided; in addition, the total urokinase unit can be increased by 2 times, even 2 times or more than 3 times.

Example 2

An extraction apparatus having first and second extraction barrels is used. Laying anion exchange resin, such as dimethylethanolamine anion exchange resin, in a first extraction barrel of the extraction device; cation exchange resin, such as carboxyl cation exchange resin, is placed in the second extraction barrel of the extraction device. The amount of extraction material in each of the first and second extraction barrels is about 600mL, so the extraction apparatus totals about 1200mL of extraction material.

The test site is a toilet of school, the toilet is provided with a groove type urinal, and the length of the urine collecting groove is 2.8 meters. And placing the extraction device below a discharge port of the urine collection tank for 7 am to 6 pm. In addition, a direct current 24-hour timing controller is additionally arranged at a proper position of a water inlet pipe in the original flushing system of the toilet, and after the set time of a class is over, flushing is started once in the class.

After the placement is started, the inspection is carried out once per hour to check whether urine or water is accumulated on the surface layer of the extraction material. And after the placement is finished, the device is taken back, whether a white substance deposition layer exists on the surface of the extraction material is checked in a laboratory, and the urokinase activity value is measured. The measurement results are shown in table 2 below:

TABLE 2

Item	Flushing water	Urine retention	White object deposition layer	Urokinase Total Unit
					Day one	Is provided with	Is free of	Is free of	241,300
The next day	Is free of	At the fourth hour	Is provided with	88,600

As is also clear from Table 2 above, by providing a suitable water flow, the formation of a white deposit is substantially avoided, while urine or water accumulation on the surface of the extraction material is avoided; in addition, the total urokinase unit can be increased by more than 2 times.

The results show that the extraction system provided with the flushing device can not only avoid the blocking situation of the extraction device and avoid the trouble that the discharged urine is easy to generate putrefaction and is unpleasant to a user, but also greatly improve the extraction amount of the physiologically active substances and achieve the purposes of environmental protection, economy and high efficiency.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Modifications and variations can be made to the above-described embodiments by those skilled in the art without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or variations that can be accomplished by those skilled in the art without departing from the spirit and scope of the invention disclosed herein be covered by the appended claims.

Claims

1. An extraction system of urine physiologically active substances, comprising:

a urinal having a flushing port;

an extraction apparatus, comprising:

the extraction barrel is provided with a containing groove, and an inlet and an outlet which are positioned at two opposite sides of the containing groove; and

the extraction material is arranged in the accommodating groove and is positioned above the outlet; and

a flush device configured to supply a flush water and direct a flow of water into the inlet.

2. The system of claim 1, wherein the flushing device provides enough flushing water per time to completely cover the upper surface of the extraction material with the water entering the inlet.

3. The extraction system for urine bioactive substances as claimed in claim 2, wherein the volume of water entering the inlet is more than 3 times to not more than 5 times of the volume of the extraction material.

4. The system for extracting a physiologically active substance in urine according to claim 1, wherein the flushing device comprises a drainage tube, and one end of the drainage tube is opened to be connected with the flushing port of the urinal, and the other end of the drainage tube is opened to be positioned above the inlet.

5. The system for extracting a physiologically active substance according to urine according to claim 1, wherein the flushing device comprises a timing controller configured to control an interval of flushing.

6. The system for extracting urine bioactive substances as claimed in claim 1, wherein the extraction device further comprises a filter layer disposed above the inlet.

7. The extraction system according to claim 1, wherein the extraction device further comprises a baffle configured to guide the urine to flow into the inlet.

8. The extraction system for urine physiologically active substance according to claim 1, wherein the extraction material is at least one selected from the group consisting of ion exchange resin, polymer fiber, chitosan and a combination thereof, and the physiologically active substance comprises urokinase, urotrypsin inhibitor, macrophage colony stimulating factor or a combination thereof.

9. A method for extracting a physiologically active substance from urine, comprising:

providing the extraction system of claim 1;

enabling urine to flow into the extraction barrel from the inlet of the extraction device, and enabling the urine to be discharged out of the extraction barrel from the outlet after the extraction material adsorbs physiologically active substances in the urine through the extraction material in the accommodating groove;

starting the flushing device to supply flushing water, so that water flow enters the inlet, passes through the extraction material in the accommodating groove and is discharged out of the extraction barrel through the outlet;

recovering the extraction material in the extraction unit; and

treating the extraction material with a desorbent to obtain a solution containing the physiologically active substance.

10. The method of claim 9, wherein the water entering the inlet is sufficient to completely cover the upper surface of the extraction material before exiting the extraction barrel.