CN111569147A - Medical engineering material containing graphene - Google Patents

Medical engineering material containing graphene Download PDF

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Publication number
CN111569147A
CN111569147A CN202010314725.3A CN202010314725A CN111569147A CN 111569147 A CN111569147 A CN 111569147A CN 202010314725 A CN202010314725 A CN 202010314725A CN 111569147 A CN111569147 A CN 111569147A
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graphene
polyoxypropylene polyoxyethylene
microcrystalline cellulose
hydroxyapatite
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王文彬
张晓梦
田小军
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Affiliated Hospital of University of Qingdao
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Affiliated Hospital of University of Qingdao
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/08—Carbon ; Graphite
    • A—HUMAN NECESSITIES
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/12—Phosphorus-containing materials, e.g. apatite
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
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    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
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    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
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    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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Abstract

The invention discloses a medical engineering material containing graphene, which comprises the following raw materials in parts by weight: 10-30 parts of polyoxypropylene polyoxyethylene block copolymer, 5-15 parts of hydroxyapatite, 12-25 parts of sodium hyaluronate, 15-32 parts of konjac glucomannan, 20-45 parts of polyoxypropylene polyoxyethylene random copolymer, 18-30 parts of microcrystalline cellulose, 30-60 parts of gelatin, 10-25 parts of graphene water dispersion and 3-8 parts of cross-linking agent. Through the matching of the structures, the invention solves the problems that the existing tissue engineering scaffold material has weak strength or large brittleness, is difficult to meet the requirement of bearing bone repair, is difficult to provide good proliferation and growth environment for cells, is difficult to promote bone tissue repair, has poor biocompatibility and is easy to cause adverse reaction to patients in the using process.

Description

Medical engineering material containing graphene
Technical Field
The invention relates to the technical field of medical engineering materials, in particular to a medical engineering material containing graphene.
Background
Tissue engineering is an emerging discipline for constructing tissues or organs in vitro or in vivo by combining cell biology and material science, in the process of tissue engineering construction, tissue engineering materials are needed, for example, tissue engineering scaffold materials refer to materials which can be combined with tissue living cells and implanted into different tissues of organisms, and according to functions of specific substitute tissues, in order to proliferate and differentiate the seed cells, it is necessary to provide a tissue engineering scaffold composed of a biomaterial, the scaffold material is equivalent to an artificial extracellular matrix, engineering scaffolds are often needed in the process of repairing bone injury, the repair of bone defects has been the key subject of continuous and deep research for centuries, and with the continuous progress of biomedical and tissue engineering research, the research on materials of tissue engineering scaffolds is concerned by researchers. The existing tissue engineering scaffold material has weak strength or high brittleness, is difficult to meet the requirement of bearing bone repair, is difficult to provide good proliferation and growth environment for cells, is difficult to promote bone tissue repair, has poor biocompatibility, and is easy to generate adverse reaction for patients in the using process, so the improvement is needed.
Disclosure of Invention
The invention aims to provide a medical engineering material containing graphene, which has the advantages that the degradability of a tissue engineering scaffold in vivo is enhanced and the absorption is facilitated by the arrangement of a polyoxypropylene polyoxyethylene block copolymer, hydroxyapatite and a polyoxypropylene polyoxyethylene random copolymer, the repair of bone defects caused by bone wax can be promoted by the addition of the hydroxyapatite, the solubility and the mechanical property of insoluble drugs in water are increased by adopting nano microcrystalline cellulose, the regeneration of bones and the mineralization of bones can be promoted by sodium hyaluronate, in addition, the physical property of the hydroxyapatite can be improved by the addition of the graphene, and a better material can be provided for the tissue engineering scaffold, so that a better proliferation environment is provided for cells, the tissue engineering material can be better applied to the inside of a human body, and the manufacturing process flow of the engineering material comprises the steps of firstly, mixing the polyoxypropylene polyoxyethylene block copolymer, the hydroxyapatite and the polyoxypropylene polyoxyethylene random copolymer, The polyoxypropylene polyoxyethylene random copolymer and the gelatin are subjected to hot melting stirring, then hydroxyapatite, nano microcrystalline cellulose, sodium hyaluronate and graphene water dispersion are added to be stirred and mixed uniformly, the mixture after mixing is placed in a mold or a split charging bottle, and is placed at normal temperature for curing and forming, and then packaging and sealing are performed.
In order to achieve the purpose, the invention provides the following technical scheme: a medical engineering material containing graphene comprises the following raw materials in parts by weight: 10-30 parts of polyoxypropylene polyoxyethylene block copolymer, 5-15 parts of hydroxyapatite, 12-25 parts of sodium hyaluronate, 15-32 parts of konjac glucomannan, 20-45 parts of polyoxypropylene polyoxyethylene random copolymer, 18-30 parts of microcrystalline cellulose, 30-60 parts of gelatin, 10-25 parts of graphene water dispersion and 3-8 parts of cross-linking agent.
Preferably, the medical engineering material containing graphene comprises the following raw materials in parts by weight: 20-30 parts of polyoxypropylene polyoxyethylene block copolymer, 9-15 parts of hydroxyapatite, 15-25 parts of sodium hyaluronate, 21-32 parts of konjac glucomannan, 30-45 parts of polyoxypropylene polyoxyethylene random copolymer, 22-30 parts of microcrystalline cellulose, 45-60 parts of gelatin, 18-25 parts of graphene water dispersion and 5-8 parts of cross-linking agent.
Preferably, the medical engineering material containing graphene comprises the following raw materials in parts by weight: the composite material comprises the following raw materials in parts by weight: 26 parts of polyoxypropylene polyoxyethylene block copolymer, 13 parts of hydroxyapatite, 22 parts of sodium hyaluronate, 29 parts of konjac glucomannan, 40 parts of polyoxypropylene polyoxyethylene random copolymer, 28 parts of microcrystalline cellulose, 55 parts of gelatin, 22 parts of graphene aqueous dispersion and 6 parts of cross-linking agent.
Preferably, the cross-linking agent is sodium alginate oxide, and the microcrystalline cellulose is nano microcrystalline cellulose.
Preferably, the graphene aqueous dispersion is a graphene oxide aqueous dispersion.
Compared with the prior art, the invention has the following beneficial effects:
the invention enhances the degradability of the tissue engineering scaffold in vivo and is beneficial to absorption through the arrangement of the polyoxypropylene polyoxyethylene block copolymer, the hydroxyapatite and the polyoxypropylene polyoxyethylene random copolymer, the addition of the hydroxyapatite can promote the repair of bone wax to bone defects, and the solubility and the mechanical property of insoluble drugs in water are increased by adopting the nanocrystalline cellulose.
The konjac glucomannan has excellent forming performance and mechanical performance, and the defects of poor formability and mechanical strength of hydroxyapatite can be improved by compounding the konjac glucomannan with hydroxyapatite.
The graphene is arranged, so that the hydroxyapatite material performance can be improved, a better material can be provided for the tissue engineering support, a better proliferation environment is provided for cells, the tissue engineering material can be better applied to the inside of a human body, and meanwhile, the graphene has low cost and lower toxicity to people and the environment, has a certain antibacterial property, promotes bone tissue repair to a certain extent, and enables patients to recover better.
Fourthly, in conclusion, through the cooperation of the polyoxypropylene polyoxyethylene block copolymer, the hydroxyapatite, the polyoxypropylene polyoxyethylene random copolymer, the sodium hyaluronate, the konjac glucomannan and the graphene, a better material can be provided for a tissue engineering scaffold, so that a better proliferation environment is provided for cells, the tissue engineering material can be better applied to the inside of a human body, and meanwhile, the tissue engineering scaffold has a certain antibacterial property, bone tissue repair is promoted to a certain extent, and a patient can be better recovered.
Drawings
FIG. 1 is a diagram of a raw material composition ratio chart in an embodiment of the present invention;
FIG. 2 is a composition ratio table of the second raw material in the example of the present invention;
FIG. 3 is a composition ratio table of three raw materials in the embodiment of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, the present invention provides a technical solution:
example one
Referring to fig. 1, the present invention provides a technical solution: a medical engineering material containing graphene comprises the following raw materials in parts by weight: 10 parts of polyoxypropylene polyoxyethylene block copolymer, 5 parts of hydroxyapatite, 12 parts of sodium hyaluronate, 15 parts of konjac glucomannan, 20 parts of polyoxypropylene polyoxyethylene random copolymer, 18 parts of microcrystalline cellulose, 30 parts of gelatin, 10 parts of graphene water dispersion and 3 parts of cross-linking agent.
The cross-linking agent is sodium alginate oxide, the weight part of the sodium alginate oxide is 3 parts, the microcrystalline cellulose is nano microcrystalline cellulose, the weight part of the nano microcrystalline cellulose is 18 parts, the graphene aqueous dispersion is graphene oxide aqueous dispersion, and the weight part of the graphene oxide aqueous dispersion is 10 parts.
Example two
Referring to fig. 2, a graphene-containing medical engineering material includes the following raw materials in parts by weight: 30 parts of polyoxypropylene polyoxyethylene block copolymer, 15 parts of hydroxyapatite, 25 parts of sodium hyaluronate, 32 parts of konjac glucomannan, 45 parts of polyoxypropylene polyoxyethylene random copolymer, 30 parts of microcrystalline cellulose, 60 parts of gelatin, 25 parts of graphene water dispersion and 8 parts of cross-linking agent.
The cross-linking agent is sodium alginate oxide, the weight part of the sodium alginate oxide is 8 parts, the microcrystalline cellulose is nano microcrystalline cellulose, the weight part of the nano microcrystalline cellulose is 30 parts, the graphene aqueous dispersion is graphene oxide aqueous dispersion, and the weight part of the graphene oxide aqueous dispersion is 25 parts.
EXAMPLE III
Referring to fig. 3, a medical engineering material containing graphene comprises the following raw materials in parts by weight: the composite material comprises the following raw materials in parts by weight: 26 parts of polyoxypropylene polyoxyethylene block copolymer, 13 parts of hydroxyapatite, 22 parts of sodium hyaluronate, 29 parts of konjac glucomannan, 40 parts of polyoxypropylene polyoxyethylene random copolymer, 28 parts of microcrystalline cellulose, 55 parts of gelatin, 22 parts of graphene aqueous dispersion and 6 parts of cross-linking agent.
The cross-linking agent is sodium alginate oxide, the weight part of the sodium alginate oxide is 6 parts, the microcrystalline cellulose is nano microcrystalline cellulose, the weight part of the nano microcrystalline cellulose is 28 parts, the graphene aqueous dispersion is graphene oxide aqueous dispersion, and the weight part of the graphene oxide aqueous dispersion is 22 parts.
The working principle is as follows: when the medical engineering material containing graphene is used, the degradability of a tissue engineering scaffold in vivo is enhanced through the arrangement of the polyoxypropylene polyoxyethylene block copolymer, the hydroxyapatite and the polyoxypropylene polyoxyethylene random copolymer, the absorption is facilitated, the repair of bone wax to bone defects can be promoted through the addition of the hydroxyapatite, the solubility and the mechanical property of insoluble drugs in water are increased through the adoption of the nano microcrystalline cellulose, the regeneration of bones and the mineralization of bones can be promoted through the arrangement of the sodium hyaluronate and the konjac glucomannan, the molecules of the sodium hyaluronate contain a large number of hydroxyl groups, carboxyl groups and acetamido groups, the water absorption is strong, the biocompatibility and the biodegradability are good, and the konjac glucomannan has good water holding capacity, biocompatibility and degradability, so the konjac glucomannan has good forming performance and mechanical property, can improve the shortcoming that hydroxyapatite formability and mechanical strength are poor through the complex with the hydroxyapatite, in addition, konjaku glucomannan and sodium hyaluronate's microstructure, physicochemical property are very similar, so can compound well with sodium hyaluronate, can improve hydroxyapatite material performance, can provide better material for tissue engineering support, thereby for the cell provides the environment of better hyperplasia, make tissue engineering material can be better application inside the human body, graphite alkene has cheap cost and lower toxicity to people and environment simultaneously, and has certain bacterinertness, bone tissue repair has been promoted to a certain extent, make better the recovering of carrying on of patient.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (5)

1. A medical engineering material containing graphene is characterized in that: the composite material comprises the following raw materials in parts by weight: 10-30 parts of polyoxypropylene polyoxyethylene block copolymer, 5-15 parts of hydroxyapatite, 12-25 parts of sodium hyaluronate, 15-32 parts of konjac glucomannan, 20-45 parts of polyoxypropylene polyoxyethylene random copolymer, 18-30 parts of microcrystalline cellulose, 30-60 parts of gelatin, 10-25 parts of graphene water dispersion and 3-8 parts of cross-linking agent.
2. The graphene-containing medical engineering material according to claim 1, wherein: the composite material comprises the following raw materials in parts by weight: 20-30 parts of polyoxypropylene polyoxyethylene block copolymer, 9-15 parts of hydroxyapatite, 15-25 parts of sodium hyaluronate, 21-32 parts of konjac glucomannan, 30-45 parts of polyoxypropylene polyoxyethylene random copolymer, 22-30 parts of microcrystalline cellulose, 45-60 parts of gelatin, 18-25 parts of graphene water dispersion and 5-8 parts of cross-linking agent.
3. The graphene-containing medical engineering material according to claim 1, wherein: the composite material comprises the following raw materials in parts by weight: the composite material comprises the following raw materials in parts by weight: 26 parts of polyoxypropylene polyoxyethylene block copolymer, 13 parts of hydroxyapatite, 22 parts of sodium hyaluronate, 29 parts of konjac glucomannan, 40 parts of polyoxypropylene polyoxyethylene random copolymer, 28 parts of microcrystalline cellulose, 55 parts of gelatin, 22 parts of graphene aqueous dispersion and 6 parts of cross-linking agent.
4. The graphene-containing medical engineering material according to claim 1, wherein: the cross-linking agent is sodium alginate oxide, and the microcrystalline cellulose is nano microcrystalline cellulose.
5. The graphene-containing medical engineering material according to claim 1, wherein: the graphene aqueous dispersion is graphene oxide aqueous dispersion.
CN202010314725.3A 2020-04-10 2020-04-10 Medical engineering material containing graphene Pending CN111569147A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102380128A (en) * 2011-10-31 2012-03-21 昆明理工大学 Hydroxyapatite, sodium hyaluronate and konjac glucomannan composite material and preparation method thereof
CN109125791A (en) * 2018-09-29 2019-01-04 广州贝奥吉因生物科技有限公司 A kind of absorbable bone wax and preparation method with promotion Bone Defect Repari function

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102380128A (en) * 2011-10-31 2012-03-21 昆明理工大学 Hydroxyapatite, sodium hyaluronate and konjac glucomannan composite material and preparation method thereof
CN109125791A (en) * 2018-09-29 2019-01-04 广州贝奥吉因生物科技有限公司 A kind of absorbable bone wax and preparation method with promotion Bone Defect Repari function

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
王学东，马丽英主编: "《医用化学实验》", 30 September 2014, 济南：山东人民出版社 *

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