CN111544770A - Electrical stimulation device - Google Patents

Electrical stimulation device Download PDF

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Publication number
CN111544770A
CN111544770A CN202010379301.5A CN202010379301A CN111544770A CN 111544770 A CN111544770 A CN 111544770A CN 202010379301 A CN202010379301 A CN 202010379301A CN 111544770 A CN111544770 A CN 111544770A
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Prior art keywords
module
current source
electrical stimulation
control
current
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左改林
赖忠云
王守东
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Hangzhou Shenluo Medical Technology Co ltd
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Hangzhou Shenluo Medical Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36064—Epilepsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36067—Movement disorders, e.g. tremor or Parkinson disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36125—Details of circuitry or electric components
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36157—Current
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
    • G01D21/00—Measuring or testing not otherwise provided for
    • G01D21/02—Measuring two or more variables by means not covered by a single other subclass
    • G—PHYSICS
    • G08—SIGNALLING
    • G08C—TRANSMISSION SYSTEMS FOR MEASURED VALUES, CONTROL OR SIMILAR SIGNALS
    • G08C17/00—Arrangements for transmitting signals characterised by the use of a wireless electrical link
    • G08C17/02—Arrangements for transmitting signals characterised by the use of a wireless electrical link using a radio link
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J50/00—Circuit arrangements or systems for wireless supply or distribution of electric power
    • H02J50/10—Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
    • H02J7/02—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from ac mains by converters

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Hospice & Palliative Care (AREA)
  • Physiology (AREA)
  • Biophysics (AREA)
  • Electrotherapy Devices (AREA)

Abstract

The present specification discloses an electrical stimulation device comprising: the current source module is connected with the current source reversing module and is used for outputting a target current with a first polarity to the current source reversing module; the control module is connected with the current source reversing module and used for alternately outputting a first control signal and a second control signal to the current source reversing module; the current source reversing module is connected with the electrode pair and used for outputting the target current of the first polarity to the electrode pair under the condition of receiving the first control signal; the current source reversing module is further configured to switch the target current on the electrode pair to a target current of a second polarity when receiving the second control signal. Thereby effectively reducing the electrode polarization phenomenon of the electrical stimulation device.

Description

Electrical stimulation device
Technical Field
The specification relates to the technical field of medical instruments, in particular to an electrical stimulation device.
Background
For some types of nervous system diseases, such as Parkinson's disease, epilepsy, intractable pain, torsion spasm, spastic torticollis, chorea, idiopathic vertigo, etc., the clinical common treatment and surgical treatment have side effects and sometimes cause some complications. The electrical stimulation therapy performs chronic electric pulse stimulation on corresponding targets of different diseases, such as stimulating thalamic nucleus and globus pallidus for Parkinson disease and stimulating vagus nerve for epilepsy, has the effect of treatment on factors and small side effect, and is an ideal treatment method.
However, the existing implantable electrical stimulation device has single function, limited pulse parameter adjustment range and limited energy source, and is far from meeting the requirements of clinical treatment and research. And the electrode of the existing implanted electric stimulation device is easy to generate polarization phenomenon, which causes the damage of tissues and organs.
Disclosure of Invention
The present description provides an electrostimulation device to overcome the drawback of the prior art that electrodes of electrostimulation devices are prone to polarization.
Specifically, the description is realized by the following technical scheme:
there is provided an electrical stimulation apparatus comprising:
the current source module is connected with the current source reversing module and is used for outputting a target current with a first polarity to the current source reversing module;
the control module is connected with the current source reversing module and used for alternately outputting a first control signal and a second control signal to the current source reversing module;
the current source reversing module is connected with the electrode pair and used for outputting the target current of the first polarity to the electrode pair under the condition of receiving the first control signal;
the current source reversing module is further configured to switch the target current on the electrode pair to a target current of a second polarity when receiving the second control signal.
Optionally, the current source commutation module comprises: the device comprises a first movable end, a second movable end, a first immovable end, a second immovable end, a third immovable end and a fourth immovable end;
the first movable end and the second movable end of the current source reversing module are respectively connected with two electrodes of the electrode pair, the first immovable end and the second immovable end of the current source reversing module are both connected with the output end of the current source module, the third immovable end and the fourth immovable end of the current source reversing module are both grounded, and the control end of the current source reversing module is connected with the control module;
under the condition that the control end receives the first control signal, the current source reversing module controls the first movable end to be connected with the fourth immovable end, and the second movable end is connected with the second immovable end so as to output the target current of the first polarity to the electrode pair;
and under the condition that the control end receives the second control signal, the current source reversing module controls the first movable end to be connected with the first immovable end, and the second movable end is connected with the third immovable end so as to output the target current of the second polarity to the electrode pair.
Optionally, the current source module comprises: the power supply comprises a power supply input end, a power supply output end, a first operational amplifier, a second operational amplifier, a first resistor, a second resistor and a third resistor;
the positive input end of the first operational amplifier is connected with the power input end, the negative input end of the first operational amplifier is grounded, the output end of the first operational amplifier is connected with one end of the first resistor, the other end of the first resistor is connected with the positive input end of the second operational amplifier, the positive input end of the second operational amplifier is further connected with the power output end, the negative input end and the output end of the second operational amplifier are both connected with one end of the second resistor, the other end of the second resistor is connected with the positive input end of the first operational amplifier, one end of the third resistor is connected with the negative input end of the first operational amplifier, and the other end of the third resistor is connected with the output end of the first operational amplifier.
Optionally, the current source module further comprises:
the current adjusting component is used for adjusting the amplitude of the target current output by the current source module under the condition of receiving a third control signal sent by the control module, the third control signal is generated according to an electrical stimulation strategy, and different electrical stimulation strategies correspond to different amplitudes of the target current.
Optionally, the current regulation assembly comprises: the device comprises a control end, at least one movable end and at least two immovable ends;
the control end is connected with the control module, the at least one movable end is connected with one end of the first resistor, and the at least two immovable ends are respectively connected with the other end of the first resistor through a resistor;
and under the condition that the control end receives the third control signal, the current adjusting component controls at least one movable end to be connected with at least one fixed end so as to adjust the amplitude of the target current output by the current source module by changing the resistance value of the first resistor.
Optionally, the electrical stimulation apparatus further comprises:
the power supply module is connected with the current source module and is used for providing power supply voltage for the current source module;
the impedance detection module is connected with the control module and is used for detecting the impedance between the two electrode pairs and sending the impedance to the control module so that the control module adjusts the power supply voltage output to the current source module by the power supply module according to the impedance, and the power supply voltage and the impedance are in positive correlation;
the current source module is used for converting the power supply voltage into the target current.
Optionally, the power supply module comprises: the DC/DC component is respectively connected with the battery component and the D/A digital-to-analog conversion component;
the battery assembly is used for outputting the stored voltage to the DC/DC assembly;
the DC/DC component is used for converting input voltage into supply voltage and outputting the supply voltage to the current source module through the D/A digital-to-analog conversion component.
Optionally, the power supply module further comprises: the wireless charging coil and the power supply management assembly are respectively connected with the battery assembly and the charging coil;
the wireless charging coil is used for receiving an electromagnetic signal sent by an external power supply and converting the electromagnetic signal into a voltage signal;
the power management assembly is connected with the wireless charging coil and used for carrying out voltage conversion on the voltage signal and storing the converted voltage in the battery assembly.
Optionally, the electrical stimulation apparatus further comprises: a multiplexer;
the electrical stimulation device comprises a plurality of electrodes;
the multi-path selector comprises an input end and a plurality of output ends, the input end of the multi-path selector is connected with the current source reversing module, each output end of the multi-path selector is connected with one electrode, and the control end of the multi-path selector is connected with the control module;
and under the condition that the control end receives a fourth control signal sent by the control module, the multiplexer determines a target electrode from the plurality of electrodes and forms an electrode pair, the input end is controlled to be connected with the output end connected with the target electrode, the fourth control signal is generated according to an electrical stimulation strategy, and different electrical stimulation strategies correspond to different target electrodes.
Optionally, the electrical stimulation apparatus further comprises:
the state detection module is connected with the control module and used for detecting the motion state of a target object implanted into the electrical stimulation device and sending the motion state to the control module so that the control module can determine an electrical stimulation strategy according to the motion state, wherein the electrical stimulation strategy comprises the amplitude and/or frequency of the target current;
and/or the temperature and humidity detection module is connected with the control module and is used for detecting the temperature and humidity in the electrical stimulation device and sending the temperature and humidity to the control module;
and/or the wireless communication module is connected with the control module and is used for establishing the communication connection between the control module and peripheral equipment.
The technical scheme provided by the embodiment of the specification can have the following beneficial effects:
in the embodiment of the present specification, the direction of the target current output to the electrode pair is switched by the current source commutation module, so that the polarity switching of the current on the electrode pair is realized, and thus the polarization phenomenon of the electrode pair can be effectively reduced.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the specification.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the present specification and together with the description, serve to explain the principles of the specification.
FIG. 1 is a block schematic diagram of an electrical stimulation apparatus shown in accordance with an exemplary embodiment of the present description;
FIG. 2a is a schematic diagram of the electrical connections of an electrical stimulation apparatus shown in accordance with an exemplary embodiment of the present description;
FIG. 2b is a schematic diagram of the electrical connections of another electrostimulation device shown in accordance with an exemplary embodiment of the present description;
FIG. 3 is a schematic circuit connection diagram of another electrostimulation device shown in accordance with an exemplary embodiment of the present description;
FIG. 4 is a block schematic diagram of another electrical stimulation apparatus shown in accordance with an exemplary embodiment of the present description;
fig. 5 is a schematic block diagram illustrating portions of another electrical stimulation apparatus according to an exemplary embodiment of the present disclosure.
Detailed Description
Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments do not represent all embodiments consistent with the present specification. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the specification, as detailed in the appended claims.
The terminology used in the description herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the description. As used in this specification and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.
It should be understood that although the terms first, second, third, etc. may be used herein to describe various information, these information should not be limited to these terms. These terms are only used to distinguish one type of information from another. For example, the first information may also be referred to as second information, and similarly, the second information may also be referred to as first information, without departing from the scope of the present specification. The word "if" as used herein may be interpreted as "at … …" or "when … …" or "in response to a determination", depending on the context.
FIG. 1 is a block schematic diagram of an electrical stimulation apparatus shown herein according to an exemplary embodiment, the electrical stimulation apparatus comprising: the current source module 11, the control module 12, the current source commutation module 13 and a plurality of electrodes, any two of the plurality of electrodes can form an electrode pair 14, and the current source commutation module 13 is respectively connected with the current source module 11, the control module 12 and the electrode pair 14. The current source module 11 outputs the target current to the electrode pair 14 through the current source reversing module 13, and the current source reversing module 13 alternately switches the direction of the target current output to the electrode pair 14 under the control of the control module 12, so that the electrode pair 14 alternately applies the positive target current and the negative target current to the target object, thereby effectively reducing the polarization phenomenon of the electrode pair and reducing the damage to the target object tissue.
The working principle of using the electrical stimulation device for electrical stimulation is further described below by taking a group of electrode pairs as an example:
before performing electrical stimulation, it is necessary to attach the electrode pair of the electrical stimulation apparatus to the target object. Wherein, the target object is a certain tissue of a patient needing electrical stimulation treatment, for example, for treating parkinson's disease, the target object can be a subthalamic nucleus and a globus pallidus, and the electrode pair is attached to the subthalamic nucleus and the globus pallidus; for the treatment of epilepsy, the target object may be the vagus nerve, and the electrode pair is attached to the vagus nerve.
After the electrical stimulation device is started, the current source module 11 outputs a target current of a first polarity to the current source commutation module 13. The control module 12 will alternately output the first control signal and the second control signal to the current source commutation module 13. The current source commutation module 13 directly outputs the target current of the first polarity to the electrode pair when receiving the first control signal, so that the electrode pair applies the target current of the first polarity to the target object. The current source commutation module 13 switches the polarity of the target current applied to the electrode pair upon receiving the second control signal, so that the electrode pair applies the target current of the second polarity to the target object.
The target current of the first polarity and the target current of the second polarity have the same amplitude and opposite directions. The target current of the first polarity may be a positive direct current or a negative direct current. If the target current of the first polarity is positive direct current, the target current is converted into negative direct current through the reversing of the current source reversing module; if the target current of the first polarity is negative direct current, the target current is converted into positive direct current through the commutation of the current source commutation module. Therefore, the electrode pair alternately applies positive direct current and negative direct current to the target object for electrical stimulation.
On the basis of the electrostimulation device shown in fig. 1, fig. 2a and 2b are schematic circuit connection diagrams of an electrostimulation device shown in the present description according to an exemplary embodiment. Referring to fig. 2a and 2b, the current source module 11 includes: a power input terminal CS _ IN, a power output terminal CS _ OUT, a first operational amplifier UAA second operational amplifier UBThe circuit comprises a first resistor R1, a second resistor R2, a third resistor R3, a fourth resistor R4 and a fifth resistor R5. A first operational amplifier UAIs connected to the power supply input terminal CS _ IN via a fourth resistor R4, a first operational amplifier UAIs grounded through a fifth resistor R5, a first operational amplifier UAThe negative input terminal of the first operational amplifier U is also connected with the first operational amplifier U through a third resistor R3AIs connected to the output of a first operational amplifier UAThe output end of the first resistor R1 is further connected with one end of a first resistor R1, and the other end of the first resistor R3578 is connected with a second operational amplifier UBIs connected to the positive input terminal of a second operational amplifier UBIs further connected to the power supply output terminal CS _ OUT, a second operational amplifier UBThe negative input end and the output end of the first resistor are both connected with one end of a second resistor R2, and the other end of the second resistor R2 is connected with a first operational amplifier UAIs connected to the positive input terminal.
The current source commutation module 13 includes a first moving terminal IN1, a second moving terminal IN2, a first stationary terminal OUT1, a second stationary terminal OUT2, a third stationary terminal OUT3 and a fourth stationary terminal OUT 4. The first moving end IN1 and the second moving end IN2 of the current source commutation module 13 are respectively connected with two electrodes C of the electrode pair, the first stationary end OUT1 and the second stationary end OUT2 of the current source commutation module are both connected with the output end CS _ OUT of the current source module 11, the third stationary end OUT3 and the fourth stationary end OUT4 of the current source commutation module 13 are both grounded, and the control end VC _ MCU of the current source commutation module 13 is connected with the control module.
The first control signal and the second control signal output by the control module 12 may be characterized by a pulse signal, for example, a high level represents the first control signal and a low level represents the second control information, or a high level represents the second control signal and a low level represents the first control information. In the following, with reference to fig. 2a and fig. 2b, the operation principle of the current source commutation module is described as follows, taking the high level as the first control signal and the low level as the second control signal as an example:
referring to fig. 2a, if the control terminal VC _ MCU of the current source commutation module 13 receives a high level output from the control module, the current source commutation module controls the first moving terminal IN1 to be connected to the fourth stationary terminal OUT4, and the second moving terminal IN2 to be connected to the second stationary terminal OUT2, at this time, the current flow direction of the current source commutation module 11 is from IN2 to IN1, that is, the current source commutation module 11 outputs the target current output from the power output terminal CS _ OUT of the current source module 11 to the two electrodes C of the electrode pair along OUT2 and IN2, and the resistor R IN the figure is a resistor RLIs the equivalent resistance of the target object.
Referring to fig. 2b, if the control terminal VC _ MCU of the current source commutating module 13 receives the low level output by the control module, the current source commutating module controls the first moving terminal IN1 to be connected to the first stationary terminal OUT1, and the second moving terminal IN2 to be connected to the third stationary terminal OUT3, at this time, the current flow direction of the current source commutating module 11 is from IN1 to IN2, that is, the current source commutating module 11 outputs the target current of the first polarity output by the power output terminal CS _ OUT of the current source module to the two electrodes C of the electrode pair along OUT1 and IN1, so as to realize polarity switching of the target current applied to the electrode pair.
Therefore, under the alternate control of the control module at a high level and a low level, the electrode pair repeatedly and alternately applies positive direct current and negative direct current to the target object, and the bidirectional current output is realized by using the current source reversing module.
It can be understood that, the duration of the positive direct current and the negative direct current applied to the target object by the electrode pair is related to the switching frequency of the current source commutation module, and is related to the duty ratio of the pulse signal (representing the first control signal and the second control signal), if the duty ratio of the high level and the low level IN one period is 50%, the duration of the target current applied to the electrode IN the flowing direction of OUT2 → IN2 → IN1 is equal to the duration of the target current applied to the electrode IN the flowing direction of OUT1 → IN1 → IN2, that is, the amount of the positive direct current on the electrode pair is equal to the amount of the negative direct current, so that the polarization phenomenon of the electrode pair can be effectively prevented.
Fig. 3 is a circuit connection schematic diagram of another electrical stimulation apparatus shown in the present description according to an exemplary embodiment, and referring to fig. 3, the current source module further includes: current regulating assembly UCCurrent regulating assembly UCConnected to the control module 12, a current regulating assembly UCFor adjusting the magnitude of the target current output by the current source module upon receiving a third control signal sent by the control module 12. And generating a third control signal according to the electric stimulation strategy, wherein different electric stimulation strategies correspond to different amplitudes and frequencies of the target current.
The electrical stimulation strategy may be pre-configured and stored in the control module by the healthcare worker, and different electrical stimulation strategies may be configured for different lesions and severity levels, and may include, but are not limited to, the following information: the amplitude, the frequency, the duration of the electrical stimulation, the duty cycle of the first control signal and the second control signal, etc., of the target current, the electrode outputting the target current, etc.
Multiple electrical stimulation strategies may be configured in the control module, and in one embodiment, a user may select an electrical stimulation strategy via a remote control outside the body.
In another embodiment, the electrical stimulation apparatus may automatically select an electrical stimulation strategy based on the patient's motion state. In this embodiment, a state detection module needs to be further disposed in the electrical stimulation device and connected to the control module, and the state detection module is configured to detect a motion state of a patient implanted with the electrical stimulation device and send the motion state to the control module, so that the control module selects an appropriate electrical stimulation strategy according to the motion state. The state detection module may be, but is not limited to, at least one of a gyroscope, an acceleration sensor, and a magnetic field sensor.
For example, if 2 electrical stimulation strategies are stored in the control module, one of the electrical stimulation strategies corresponds to the patient being in a stationary state, and the other of the electrical stimulation strategies corresponds to the patient being in a mobile state. If the state detection module detects that the patient is in a static state, the control module adopts an electrical stimulation strategy one, for example, the target current is about 20mA, and the pulse frequency of the target current is 5-20 times per minute, so as to control the switching frequency of a switch of the current source reversing module and the amplitude and frequency of the target current output by the current source module; if the state detection module detects that the patient is in a motion state, an electrical stimulation strategy II is adopted, for example, the target current is 2 mA-20 mA, and the pulse frequency of the target current is 50-200 times per minute, so that the switching frequency of the switch of the current source reversing module and the amplitude and the frequency of the target current output by the current source module are controlled. Therefore, in the rest state, the lower stimulation frequency is used, and the influence on rest is avoided; in the motion state, a higher stimulation frequency is used, and a good stimulation treatment effect is achieved.
The following describes a specific implementation process of the current regulating assembly:
in one embodiment, the current regulation component comprises a control terminal VC _ MCU, at least one movable terminal and at least two immovable terminals, the control terminal is connected with the control module, the at least one movable terminal is connected with one end of the first resistor, and the at least two immovable terminals are respectively connected with the other end of the first resistor through a resistor. Under the condition that the control end receives a third control signal, the current adjusting component controls at least one movable end to be connected with at least one fixed end so as to adjust the amplitude of the target current output by the current source module by changing the resistance value of the first resistor. Thereby, the current regulating component U is regulated by controllingCThe switch switches on R6-R9 in different combinations, and combines with R1 to form different resistance values, so that the aim of outputting different target current waveforms and amplitudes under the condition that the power supply module outputs the same voltage waveform and amplitude is fulfilled, and the double-phase current with different current amplitudes can be output to the electrode pair under the condition of single-phase power supply by combining the current source reversing module.
It should be noted that the active terminals of the current regulating component are not limited to the 2 active terminals (IN1, IN2) shown IN the figure, and the inactive terminals are not limited to the 4 inactive terminals (OUT1, OUT2, OUT3 and OUT4) shown IN the figure, and the number of the active terminals and the number of the inactive terminals can be set according to the number of the electrical stimulation strategies. Taking the current adjusting component shown in fig. 3 as an example, in this embodiment, by switching the switch, the resistance of the first resistor may be changed in a manner that resistors are connected in parallel at two ends of the first resistor R1, so as to change the amplitude of the target current output by the current source module. If the resistances of the resistors connected with the 4 motionless ends are different, the first resistor R1 can be connected in parallel with the resistors with the 4 resistances through switching, the current regulating assembly also comprises a condition that the current regulating assembly does not work (the first resistor R1 is not connected in parallel with any resistor), and the current source module can output 5 target currents with different amplitudes, so that 5 electrical stimulation strategies can be correspondingly set. For example, if IN1 is connected to OUT1 and IN2 is connected to OUT4, the magnitude of the target current output by the current source module is related to R1, R6 and R9; if the IN1 is connected to the OUT2 and the IN2 is connected to the OUT4, the magnitude of the target current output by the current source module is related to R1, R7 and R9. And the resistance values of R1 and R6-R9 can be set according to actual requirements, so that the amplitude of the target current output by the current source module is accurately controlled by controlling the switch switching of the current regulating component.
In another embodiment, the electrical stimulation apparatus further comprises: the current source commutation module is connected with the input end of the multiplexer, each output end of the multiplexer is connected with one electrode, and the control end of the multiplexer is connected with the control module; and under the condition that the control end receives a fourth control signal sent by the control module, the multiplexer determines that a target electrode in the plurality of electrodes forms an electrode pair, the input end of the multiplexer is connected with the output end connected with the target electrode, the fourth control signal is generated according to an electrical stimulation strategy, and different electrical stimulation strategies correspond to different target electrodes.
On the basis of the electrical stimulation apparatus shown in fig. 1, fig. 4 is a schematic block diagram of another electrical stimulation apparatus shown in the present specification according to an exemplary embodiment, and the electrical stimulation apparatus further includes: and the power supply module is used for supplying power to other modules in the device. Referring to fig. 4, the power supply module includes a wireless charging coil T, a power management assembly, a battery assembly, a DC/DC assembly, and a D/a digital-to-analog conversion assembly. The wireless charging coil T is connected with the power management assembly, the power management assembly is further connected with the battery assembly, and the DC/DC assembly is respectively connected with the battery assembly and the D/A digital-to-analog conversion assembly.
The working principle of the power supply module is described as follows:
the wireless charging coil receives an electromagnetic signal sent by an external power supply and converts the electromagnetic signal into a voltage signal. The power management component converts the voltage of the voltage signal and stores the converted voltage in the battery component. Specifically, a voltage signal received by the power management component is subjected to voltage conversion through the AD/DC unit to form a direct current power supply, the formed direct current power supply is subjected to overvoltage/overcurrent protection unit to monitor and detect voltage and current in the circuit, so as to protect the circuit, and then the converted power supply is provided for the battery component (which can be but is not limited to a lithium ion battery) to be charged through the charging management unit.
And in the working process of the electrical stimulation device, the battery component outputs the stored power supply to the DC/DC component. The Boost circuit of the DC/DC component converts an input voltage into a first target voltage (e.g., 5V to 25V) and supplies power to the current source module, the current source commutation module, and the MUX. The Buck-Boost circuit of the DC/DC component converts the input voltage into a second target voltage (for example, 3.3V), outputs the second target voltage to the control module and outputs the second target voltage to the current source module through the D/A digital-to-analog conversion component, and the second target voltage is used as a reference voltage of a target current output by the current source module, so that the current source module outputs a corresponding electrical stimulation current waveform (target current) according to the voltage waveform output by the D/A digital-to-analog conversion component.
In another embodiment, the electrical stimulation apparatus further comprises an impedance detection module connected to the control module. In the working process of the electrical stimulation device, the impedance detection module detects the impedance R between the two electrode pairs in real timeLThe power supply voltage is transmitted to the control module, so that the control module adjusts the power supply voltage output to the current source module by the power supply module according to the impedance, and the power supply voltage is positively correlated with the impedance; the current source module is used for converting the supply voltage into a target current.
Fig. 5 is a schematic block diagram of a portion of another electrical stimulation apparatus according to an exemplary embodiment, and the implementation process of adjusting the output voltage of the power supply module is described below with reference to fig. 5:
if the impedance RLAnd increasing the amplitude of the target current, wherein the amplitude of the target current needs to be increased, the control module adjusts the DP digital potentiometer to reduce the resistance value of the DP digital potentiometer, and the amplitude of the voltage output by the Boost circuit is increased by using the DP digital potentiometer. If the impedance RLAnd when the amplitude of the target current is reduced, the amplitude of the target current needs to be reduced, the control module adjusts the DP digital potentiometer to increase the resistance value of the DP digital potentiometer, and then the amplitude of the voltage output by the Boost circuit is reduced by using the DP digital potentiometer. Therefore, the control module outputs different resistance values to the feedback end of the Boost circuit by adjusting the DP digital potentiometer, the Boost circuit can output voltages with different amplitudes, and accurate control over ideal voltage output by the power supply module is achieved.
Because the electrical stimulation device can be an implanted electrical stimulation device, the air tightness needs to be kept when the electrical stimulation device is implanted into the body of a patient. The temperature and humidity module is used for detecting the temperature and humidity in the electrical stimulation device and sending the temperature and humidity to the control module, so that the control module can judge the air tightness of the electrical stimulation device according to the temperature and humidity and can judge whether a circuit in the device has the phenomena of short circuit, heating and the like.
In another embodiment, the electrical stimulation device further comprises a wireless communication module connected with the control module. The wireless communication module is used for establishing communication connection between the control module and the peripheral equipment, and the wireless communication module can be but is not limited to comprise a Bluetooth matching circuit and an antenna. When the control module is to send the operation data (such as temperature and humidity, working state and the like) of the electrical stimulation device to the peripheral equipment, the control module sends the operation data to the Bluetooth matching circuit, meanwhile, the Bluetooth matching circuit provides the operation data to the antenna, and the antenna sends the operation data to the peripheral equipment. Similarly, when the peripheral device sends a signal (e.g., control information) to the control module, the peripheral device sends the signal to the antenna and sends the signal to the control module via the bluetooth matching circuit.
The above description is only a preferred embodiment of the present disclosure, and should not be taken as limiting the present disclosure, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present disclosure should be included in the scope of the present disclosure.

Claims (10)

1. An electro-stimulation device, characterized in that it comprises:
the current source module is connected with the current source reversing module and is used for outputting a target current with a first polarity to the current source reversing module;
the control module is connected with the current source reversing module and used for alternately outputting a first control signal and a second control signal to the current source reversing module;
the current source reversing module is connected with the electrode pair, and is used for outputting the target current of the first polarity to the electrode pair under the condition of receiving the first control signal, and switching the target current on the electrode pair into the target current of the second polarity under the condition of receiving the second control signal.
2. The electrical stimulation apparatus as claimed in claim 1, wherein the current source commutation module comprises: the device comprises a first movable end, a second movable end, a first immovable end, a second immovable end, a third immovable end and a fourth immovable end;
the first movable end and the second movable end of the current source reversing module are respectively connected with two electrodes of the electrode pair, the first immovable end and the second immovable end of the current source reversing module are both connected with the output end of the current source module, the third immovable end and the fourth immovable end of the current source reversing module are both grounded, and the control end of the current source reversing module is connected with the control module;
under the condition that the control end receives the first control signal, the current source reversing module controls the first movable end to be connected with the fourth immovable end, and the second movable end is connected with the second immovable end so as to output the target current of the first polarity to the electrode pair;
and under the condition that the control end receives the second control signal, the current source reversing module controls the first movable end to be connected with the first immovable end, and the second movable end is connected with the third immovable end so as to output the target current of the second polarity to the electrode pair.
3. The electrical stimulation apparatus as claimed in claim 1, wherein the current source module comprises: the power supply comprises a power supply input end, a power supply output end, a first operational amplifier, a second operational amplifier, a first resistor, a second resistor and a third resistor;
the positive input end of the first operational amplifier is connected with the power input end, the negative input end of the first operational amplifier is grounded, the output end of the first operational amplifier is connected with one end of the first resistor, the other end of the first resistor is connected with the positive input end of the second operational amplifier, the positive input end of the second operational amplifier is further connected with the power output end, the negative input end and the output end of the second operational amplifier are both connected with one end of the second resistor, the other end of the second resistor is connected with the positive input end of the first operational amplifier, one end of the third resistor is connected with the negative input end of the first operational amplifier, and the other end of the third resistor is connected with the output end of the first operational amplifier.
4. The electrical stimulation apparatus as claimed in claim 3, wherein the current source module further comprises:
the current adjusting component is used for adjusting the amplitude of the target current output by the current source module under the condition of receiving a third control signal sent by the control module, the third control signal is generated according to an electrical stimulation strategy, and different electrical stimulation strategies correspond to different amplitudes of the target current.
5. The electrical stimulation apparatus as claimed in claim 4, wherein the current regulation assembly comprises: the device comprises a control end, at least one movable end and at least two immovable ends;
the control end is connected with the control module, the at least one movable end is connected with one end of the first resistor, and the at least two immovable ends are respectively connected with the other end of the first resistor through a resistor;
and under the condition that the control end receives the third control signal, the current adjusting component controls at least one movable end to be connected with at least one fixed end so as to adjust the amplitude of the target current output by the current source module by changing the resistance value of the first resistor.
6. The electrical stimulation apparatus as claimed in claim 1, wherein the electrical stimulation apparatus further comprises:
the power supply module is connected with the current source module and is used for providing power supply voltage for the current source module;
the impedance detection module is connected with the control module and is used for detecting the impedance between the two electrode pairs and sending the impedance to the control module so that the control module adjusts the power supply voltage output to the current source module by the power supply module according to the impedance, and the power supply voltage and the impedance are in positive correlation;
the current source module is used for converting the power supply voltage into the target current.
7. The electrostimulation device according to claim 6, characterised in that the power supply module comprises: the DC/DC component is respectively connected with the battery component and the D/A digital-to-analog conversion component;
the battery assembly is used for outputting the stored voltage to the DC/DC assembly;
the DC/DC component is used for converting input voltage into supply voltage and outputting the supply voltage to the current source module through the D/A digital-to-analog conversion component.
8. The electrical stimulation apparatus as claimed in claim 7, wherein the power supply module further comprises: the wireless charging coil and the power supply management assembly are respectively connected with the battery assembly and the charging coil;
the wireless charging coil is used for receiving an electromagnetic signal sent by an external power supply and converting the electromagnetic signal into a voltage signal;
the power management assembly is connected with the wireless charging coil and used for carrying out voltage conversion on the voltage signal and storing the converted voltage in the battery assembly.
9. The electrical stimulation apparatus as claimed in claim 1, wherein the electrical stimulation apparatus further comprises: a multiplexer;
the electrical stimulation device comprises a plurality of electrodes;
the multi-path selector comprises an input end and a plurality of output ends, the input end of the multi-path selector is connected with the current source reversing module, each output end of the multi-path selector is connected with one electrode, and the control end of the multi-path selector is connected with the control module;
and under the condition that the control end receives a fourth control signal sent by the control module, the multiplexer determines a target electrode from the plurality of electrodes and forms an electrode pair, the input end is controlled to be connected with the output end connected with the target electrode, the fourth control signal is generated according to an electrical stimulation strategy, and different electrical stimulation strategies correspond to different target electrodes.
10. The electrical stimulation apparatus as claimed in claim 1, wherein the electrical stimulation apparatus further comprises:
the state detection module is connected with the control module and used for detecting the motion state of a target object implanted into the electrical stimulation device and sending the motion state to the control module so that the control module can determine an electrical stimulation strategy according to the motion state, wherein the electrical stimulation strategy comprises the amplitude and/or frequency of the target current;
and/or the temperature and humidity detection module is connected with the control module and is used for detecting the temperature and humidity in the electrical stimulation device and sending the temperature and humidity to the control module;
and/or the wireless communication module is connected with the control module and is used for establishing the communication connection between the control module and peripheral equipment.
CN202010379301.5A 2020-05-07 2020-05-07 Electrical stimulation device Pending CN111544770A (en)

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