CN111543991A - Gastrointestinal tract mucous epithelium electrical impedance measurement and evaluation device - Google Patents
Gastrointestinal tract mucous epithelium electrical impedance measurement and evaluation device Download PDFInfo
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- CN111543991A CN111543991A CN201910115808.7A CN201910115808A CN111543991A CN 111543991 A CN111543991 A CN 111543991A CN 201910115808 A CN201910115808 A CN 201910115808A CN 111543991 A CN111543991 A CN 111543991A
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- sleeve
- impedance
- detection
- stroke
- detection channel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0531—Measuring skin impedance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
- A61B1/2736—Gastroscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/053—Measuring electrical impedance or conductance of a portion of the body
- A61B5/0538—Measuring electrical impedance or conductance of a portion of the body invasively, e.g. using a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6871—Stomach
Abstract
The invention discloses an electrical impedance measurement and evaluation device for gastrointestinal mucosa epithelium, which comprises a sleeve and an impedance detection tube, wherein a detection channel is arranged in the sleeve, the top end of the sleeve is a tip part, the tip part is provided with an endoscope and a detection hole, the detection hole is an outlet on the tip part of the detection channel, the middle section of the sleeve is provided with an adjuster and a stroke measurement box, the adjuster is provided with a detection channel opening which is communicated with the detection channel in the sleeve, the impedance detection tube penetrates through the detection channel opening on the adjuster and penetrates out of the detection hole on the tip part through the detection channel in the sleeve, and the end part of the impedance detection tube is provided with an impedance sensor. The impedance sensor is used as an accessory of the endoscope, the gastrointestinal tract mucosal epithelial electrical impedance can be measured during endoscopic observation to evaluate the gastrointestinal tract mucosal epithelial barrier dysfunction, a doctor can conveniently perform targeted treatment, the real-time operation can be realized, the repeated monitoring can be realized, and the clinical requirements of early diagnosis and monitoring of the gastrointestinal tract mucosal epithelial barrier dysfunction at present are met.
Description
The technical field is as follows:
the invention relates to the field of medical auxiliary instruments in the digestive system department, in particular to an electrical impedance measurement and evaluation device for gastrointestinal mucosa epithelium.
Background art:
disruption of the epithelial barrier function of the gastrointestinal tract is an important mechanism for the development of various intestinal disorders, such as inflammation, tumors, functional gastrointestinal disorders, etc., but no diagnostic method is available for early epithelial barrier dysfunction (invisible to the naked eye). There are currently three main methods for assessing gastrointestinal epithelial barrier dysfunction, the first: the biopsy pathology evaluation only can achieve the function of local epithelial evaluation, is difficult to evaluate at multiple points, causes traumatic damage to patients, and has a long waiting period for biopsy results; secondly, the method comprises the following steps: biopsy molecular biology evaluation methods, currently used only in laboratories, have not been applied clinically; thirdly, the method comprises the following steps: the confocal endoscope needs to locally use a color developing agent, has allergy risk, is expensive, can be only locally operated, is difficult to evaluate at multiple points, and has higher requirements on the diagnosis level of an endoscope physician. At present, no simple and convenient method for early diagnosis and monitoring of gastrointestinal epithelial barrier dysfunction exists.
The invention content is as follows:
technical problem to be solved
Aiming at the defects of the prior art, the invention provides the gastrointestinal tract mucosal epithelial electrical impedance measurement and evaluation device, which combines impedance measurement and an endoscope, simply and conveniently evaluates the gastrointestinal tract mucosal epithelial barrier while operating the endoscope, can be operated in real time, can be repeatedly monitored, has lower cost, and solves the clinical requirements of early diagnosis and monitoring of the gastrointestinal tract epithelial barrier function abnormality at present.
(II) technical scheme
In order to solve the technical problems, the invention provides the following technical scheme: an electrical impedance measurement and evaluation device for gastrointestinal mucosa epithelium comprises a sleeve and an impedance detection tube, wherein a detection channel is arranged in the sleeve, the top end of the sleeve is a tip part, an endoscope and a detection hole are arranged on the tip part, the detection hole is an outlet of the detection channel on the tip part, a regulator and a stroke measurement box are arranged in the middle section of the sleeve, a detection channel opening is arranged on the regulator, the detection channel opening is communicated with the detection channel in the sleeve, an impedance sensor is arranged at the end part of the impedance detection tube, the impedance sensor penetrates through the detection channel opening on the regulator and penetrates out of the detection hole on the tip part through the detection channel in the sleeve, the sleeve penetrates through the inside of the stroke measurement box and extends out of the stroke measurement box through a connector arranged on the sleeve to be connected with a linear displacement sensor, the tail end of the sleeve is provided with a sleeve box, redundant sleeves are rolled into the sleeve box to be placed and pulled out when needed, the sleeves penetrate through the sleeve box, and the sleeves and the impedance sensors are electrically connected with a processor and a display through data transmission lines. The endoscope is electrically connected with the data transmission line through the sleeve, the endoscope and the image and the data detected by the impedance sensor are transmitted to the processor through the data transmission line, the processed image and the data are transmitted to the display for display, and the adjuster can be used for adjusting the direction and the depth of the sleeve inserted into the stomach and intestine of a patient, so that the inside of the stomach and intestine of the patient can be observed conveniently in an all-dimensional mode. The regulator is arranged in front of the stroke measuring box, a switch is arranged on the regulator, the switch is electrically connected with the impedance sensor, the linear displacement sensor and the processor, and the processor is connected with the endoscope, the display and the power supply.
When the gastrointestinal mucosa epithelial electrical impedance measurement and evaluation device provided by the invention is used, the sleeve is inserted into the esophagus of a patient, the impedance detection tube and the impedance sensor at the end part of the impedance detection tube are inserted into the detection channel in the sleeve from the detection channel opening on the regulator, the impedance sensor is made to extend out of the detection hole on the front end part of the sleeve, the position of the impedance sensor in the body of the patient is observed through the endoscope, when the endoscope reaches the cardia position of the gastrointestinal part of the patient, the impedance sensor and the linear displacement sensor start to work, data are recorded and transmitted to the processor through the data transmission line for processing, the image observed by the endoscope is displayed by the display, and in addition, epithelial electrical impedance data detected by the impedance sensor and the sleeve electrical impedance data detected by the linear displacement sensor are displayed by the display The insertion depth of the tube in the gastrointestinal part of the patient obtains waveform data of the gastrointestinal epithelial electrical impedance value of the patient changing along with the insertion depth of the sleeve, and medical staff can judge the abnormal position of the gastrointestinal epithelial electrical impedance of the patient through the image and the waveform data displayed by the display, so that targeted diagnosis and treatment are carried out.
Furthermore, a stroke groove is formed in the stroke measuring box, the connector slides in the stroke groove, and the length of the stroke groove is larger than the maximum measuring stroke of the linear displacement sensor. During the process that the sleeve is inserted into the gastrointestinal part of a patient, the connector moves along with the sleeve, the moving distance of the connector can be detected through the linear displacement sensor, so that the inserting depth of the sleeve in the patient body is obtained, the length of the stroke groove is larger than the maximum measuring stroke of the linear displacement sensor, and the linear displacement sensor can be guaranteed to be capable of measuring the whole stroke of the sleeve.
Further, the maximum measuring stroke of the linear displacement sensor is larger than 600 mm. As the length of the gastrointestinal part of the adult is generally not more than 550mm, the maximum measuring stroke of the linear displacement sensor is larger than the length of the gastrointestinal part of the adult, so that the whole gastrointestinal part can be measured by the sleeve, and the measuring requirement is met.
Further, the sleeve is a flexible sleeve, the length of the sleeve before the adjuster is greater than 1000 mm. The flexible sleeve can ensure that the sleeve is convenient to turn in the body of a patient, is convenient to measure different positions of the gastrointestinal part, and avoids discomfort of the patient.
Further, the impedance sensor extends out of the detection hole by a distance not less than 5mm, and the head position of the impedance sensor can be observed through the endoscope. By adopting the arrangement mode, the endoscope can be ensured to observe the measurement position of the impedance sensor at any time when the endoscope is positioned in the gastrointestinal tract of a patient, thereby facilitating the operation of medical personnel, and meanwhile, whether the gastrointestinal tract function of the patient is normal can be comprehensively judged according to the display image of the endoscope and the measurement data of the impedance sensor.
Further, the length of the sleeve which can extend out of the sleeve box is more than 1000 mm. The cannula is ensured to have enough extending length, thereby being convenient for the operation of medical personnel.
Further, the impedance sensor is an active bioelectrical impedance sensor. The active bioelectrical impedance sensor has more sensitive measurement precision and is more suitable for measuring the epithelial electrical impedance of organisms such as human bodies.
(III) the beneficial effects are as follows:
compared with the prior art, the invention has the following beneficial effects: the impedance sensor is used as an accessory of the endoscope, and the gastrointestinal tract endoscope operation is combined, so that the gastrointestinal tract mucosal epithelial barrier is evaluated simply and conveniently while the endoscope is operated, and medical personnel can comprehensively judge the abnormal position of the gastrointestinal tract epithelial electrical impedance of a patient through measuring images and data, thereby carrying out targeted diagnosis and treatment. The method can be operated in real time, repeated monitoring is realized, the cost is low, and the clinical requirements of early diagnosis and monitoring of the gastrointestinal epithelial barrier dysfunction are effectively met.
Description of the drawings:
in order to more clearly illustrate the technical solution in the embodiments of the present invention, the drawings required to be used in the embodiments will be briefly described below.
FIG. 1 is a schematic structural diagram of an electrical impedance measurement and evaluation device for gastrointestinal mucosa epithelium according to an embodiment of the invention;
FIG. 2 is a control schematic diagram of the electrical impedance measurement and evaluation device for the gastrointestinal mucosa epithelium according to the embodiment of the invention;
FIG. 3 is a partially enlarged schematic view of the tip portion of the electrical impedance measurement and evaluation device for gastrointestinal mucosa epithelium according to the embodiment of the present invention;
in the figure: 1. an impedance detection tube; 11. an impedance sensor; 2. a sleeve; 21. a detection channel; 22. a tip portion; 23. an endoscope; 24. a detection hole; 3. a detection channel opening; 4. a regulator; 5. a switch; 6. a travel measurement box; 7. a connector; 8. a linear displacement sensor; 9. a cannula box; 10. a data transmission line; 11. a display; 12. a processor; 13. a power source; 14. stroke groove
The specific implementation mode is as follows:
the technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.
Referring to fig. 1, 2 and 3, a gastrointestinal mucosa epithelial electrical impedance measurement and evaluation device comprises a sleeve 2 and an impedance detection tube 1, wherein a detection channel 21 is arranged in the sleeve 2, the top end of the sleeve 2 is a tip part 22, the tip part 22 is provided with an endoscope 23 and a detection hole 24, the detection hole 24 is an outlet of the detection channel 21 on the tip part 22, the middle section of the sleeve 2 is provided with an adjuster 4 and a stroke measurement box 6, the adjuster 4 is provided with a detection channel opening 3, the detection channel opening 3 is communicated with the detection channel 21 in the sleeve 2, the end part of the impedance detection tube 1 is provided with an impedance sensor 11, the impedance sensor 11 penetrates through the detection channel opening 3 on the adjuster 4 and penetrates out of the detection hole 24 on the tip part 22 through the detection channel 21 in the sleeve 2, the sleeve 2 penetrates through the inside of the stroke measurement box 6 and extends out of the stroke measurement box 6 through a connector 7 arranged on the sleeve 2 to be connected with a linear, the tail end of the sleeve 2 is provided with a sleeve box 9, redundant sleeves 2 are rolled into the sleeve box 9 to be placed and pulled out when needed, the sleeve 2 penetrates through the sleeve box 9, and the sleeve 2 and the impedance sensor 11 are electrically connected with the processor 12 and the display 11 through the data transmission line 10. The endoscope 23 is electrically connected with the data transmission line 10 through the sleeve 2, images and data detected by the endoscope 23 and the impedance sensor 11 are transmitted to the processor 12 through the data transmission line 10 and are transmitted to the display 11 for display after being processed by the processor 12, and the regulator 4 can be used for regulating the direction and the depth of the sleeve 2 inserted into the stomach and intestine of a patient, so that the gastrointestinal interior of the patient can be observed conveniently in all directions. The regulator 4 is arranged in front of the stroke measuring box 6, the switch 5 is arranged on the regulator 4, the switch 5 is electrically connected with the impedance sensor 11, the linear displacement sensor 8 and the processor 12, and the processor 12 is connected with the endoscope 23, the display 11 and the power supply 13.
Preferably, the stroke measuring box 6 is provided with a stroke slot 14, the connector 7 slides in the stroke slot 14, and the length of the stroke slot 14 is larger than the maximum measuring stroke of the linear displacement sensor 8. In the process that the sleeve 2 is inserted into the gastrointestinal part of a patient, the connector 7 moves along with the sleeve 2, the moving distance of the connector 7 can be detected through the linear displacement sensor 8, so that the inserting depth of the sleeve 2 in the patient body is obtained, the length of the stroke groove 14 is larger than the maximum measuring stroke of the linear displacement sensor 8, and the linear displacement sensor 8 can be used for measuring the whole stroke of the sleeve 2.
Preferably, the maximum measuring travel of the linear displacement sensor 8 is greater than 600 mm. As the length of the gastrointestinal part of the adult is generally not more than 550mm, the maximum measuring stroke of the linear displacement sensor 8 is larger than the length of the gastrointestinal part of the adult, so that the whole gastrointestinal part can be measured by the sleeve 2, and the measuring requirement is met.
Preferably, the cannula 2 is a flexible cannula, the length of the cannula 2 before the regulator 4 being greater than 1000 mm. The flexible sleeve can ensure that the sleeve 2 is convenient to turn in the body of a patient, is convenient to measure different positions of the gastrointestinal part, and avoids discomfort of the patient.
Preferably, the impedance sensor 11 protrudes from the detection hole 24 by a distance of not less than 5mm, and the head position of the impedance sensor 11 can be observed by the endoscope 23. By adopting the arrangement mode, the endoscope 23 can observe the measurement position of the impedance sensor 11 at any time when the gastrointestinal part of the patient is positioned, the operation of medical personnel is convenient, and meanwhile, whether the gastrointestinal function of the patient is normal can be comprehensively judged according to the display image of the endoscope 23 and the measurement data of the impedance sensor 11.
Preferably, the length of the extendable cannula 2 inside the cannula housing 9 is larger than 1000 mm. The cannula 2 is ensured to have enough extending length, which is convenient for the operation of medical staff.
Preferably, the impedance sensor 11 is an active bioelectrical impedance sensor. The active bioelectrical impedance sensor has more sensitive measurement precision and is more suitable for measuring the epithelial electrical impedance of organisms such as human bodies.
The working principle of the invention is as follows:
when the gastrointestinal mucosal epithelial electrical impedance measurement and evaluation device provided by the invention is used, the cannula 2 is inserted into the esophagus of a patient, the impedance detection tube 1 and the impedance sensor 11 at the end part of the impedance detection tube 1 are inserted into the detection channel 21 in the cannula 2 from the detection channel opening 3 on the regulator 4, the impedance sensor 11 is made to extend out from the detection hole 24 on the front end part 22 of the cannula 2, the position of the impedance sensor 11 in the body of the patient is observed through the endoscope 23, when the endoscope 23 reaches the cardia position of the gastrointestinal part of the patient, the switch 5 is pressed, the impedance sensor 11 and the linear displacement sensor 8 start to work, data is recorded and is transmitted to the processor 12 through the data transmission line 10 for processing, the display 11 displays an image observed by the endoscope 23, the display 11 also displays epithelial electrical impedance data detected by the impedance sensor 11 and the insertion depth of the cannula 2 in the gastrointestinal part of the patient detected by the linear displacement sensor 8, waveform data of the impedance value of the gastrointestinal mucosa epithelium of the patient changing along with the insertion depth of the cannula 2 is obtained, and medical care personnel can judge the abnormal position of the impedance of the gastrointestinal mucosa epithelium of the patient through the image and the waveform data displayed by the display 11, thereby carrying out targeted diagnosis and treatment.
The present invention has been described above by way of example, but the present invention is not limited to the above-described specific embodiments, and any modification or variation made based on the present invention is within the scope of the present invention as claimed.
Claims (7)
1. An electrical impedance measurement and evaluation device for gastrointestinal mucosa epithelium is characterized in that: the device comprises a sleeve and an impedance detection tube, wherein a detection channel is arranged in the sleeve, the top end of the sleeve is a tip part, an endoscope and a detection hole are arranged on the tip part, the detection hole is an outlet of the detection channel on the tip part, an adjuster and a stroke measurement box are arranged in the middle section of the sleeve, a detection channel opening is arranged on the adjuster, the detection channel opening is communicated with the detection channel in the sleeve, an impedance sensor is arranged at the end part of the impedance detection tube, the impedance sensor penetrates through the detection channel opening on the adjuster and penetrates out of the detection hole on the tip part through the detection channel in the sleeve, the sleeve penetrates through the inside of the stroke measurement box and extends out of the stroke measurement box through a connector arranged on the sleeve to be connected with a linear displacement sensor, and a sleeve box is arranged at the tail end of the sleeve, the redundant sleeve is rolled into the sleeve box to be placed, the sleeve and the impedance sensor are electrically connected with a processor and a display through data transmission lines, a switch is arranged on the regulator, the switch is electrically connected with the impedance sensor, the linear displacement sensor and the processor, and the processor is connected with the endoscope, the display and a power supply.
2. The gastrointestinal mucosal epithelial electrical impedance measurement and evaluation device according to claim 1, wherein: the stroke measuring box is provided with a stroke groove, the connector slides in the stroke groove, and the length of the stroke groove is larger than the maximum measuring stroke of the linear displacement sensor.
3. The gastrointestinal mucosal epithelial electrical impedance measurement and evaluation device according to claim 1 or 2, wherein: the maximum measuring stroke of the linear displacement sensor is larger than 600 mm.
4. The electrical impedance measurement and evaluation device for the mucosa epithelium of the gastrointestinal tract according to any one of claims 1 to 3, wherein: the sleeve is a flexible sleeve, and the length of the sleeve before the adjuster is more than 1000 mm.
5. The electrical impedance measurement and evaluation device for the mucosa epithelium of the gastrointestinal tract according to any one of claims 1 to 4, wherein: the distance that the impedance sensor extends out of the detection hole is not less than 5mm, and the head position of the impedance sensor can be observed through the endoscope.
6. The electrical impedance measurement and evaluation device for the mucosa epithelium of the gastrointestinal tract according to any one of claims 1 to 5, wherein: the length of the sleeve which can extend out of the sleeve box is more than 1000 mm.
7. The electrical impedance measurement and evaluation device for the mucosa epithelium of the gastrointestinal tract according to any one of claims 1 to 6, wherein: the impedance sensor is an active bioelectrical impedance sensor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910115808.7A CN111543991A (en) | 2019-02-15 | 2019-02-15 | Gastrointestinal tract mucous epithelium electrical impedance measurement and evaluation device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910115808.7A CN111543991A (en) | 2019-02-15 | 2019-02-15 | Gastrointestinal tract mucous epithelium electrical impedance measurement and evaluation device |
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| CN111543991A true CN111543991A (en) | 2020-08-18 |
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| CN201910115808.7A Pending CN111543991A (en) | 2019-02-15 | 2019-02-15 | Gastrointestinal tract mucous epithelium electrical impedance measurement and evaluation device |
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| CN205031258U (en) * | 2015-09-25 | 2016-02-17 | 重庆金山科技（集团）有限公司 | Visual esophagus impedance pH value monitoring devices |
| US20170143248A1 (en) * | 2010-07-13 | 2017-05-25 | Sandhill Scientific, Inc. | Method of Detecting and Measuring the Condition of Intraluminal Esophageal Mucosa |
| US20170209029A1 (en) * | 1999-03-01 | 2017-07-27 | West View Research, Llc | Computerized information collection and processing apparatus |
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2019
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Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6405732B1 (en) * | 1994-06-24 | 2002-06-18 | Curon Medical, Inc. | Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors |
| US20020138075A1 (en) * | 1998-02-19 | 2002-09-26 | Curon Medical, Inc. | Method to treat gastric reflux via the detection and ablation of gastro-esophageal nerves and receptors |
| US20170209029A1 (en) * | 1999-03-01 | 2017-07-27 | West View Research, Llc | Computerized information collection and processing apparatus |
| US20080275360A1 (en) * | 2004-05-04 | 2008-11-06 | Lars Fandriks | Arrangement and Method for Assessing the Motility of a Generally Tubular Anatomical Organ |
| CN101252878A (en) * | 2005-01-04 | 2008-08-27 | 沙丘医疗设备有限公司 | Endoscopic system for in-vivo procedures |
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Application publication date: 20200818 |
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