CN111543939A - Ultrasonic detection device and medical imaging system - Google Patents
Ultrasonic detection device and medical imaging system Download PDFInfo
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- CN111543939A CN111543939A CN201910523549.1A CN201910523549A CN111543939A CN 111543939 A CN111543939 A CN 111543939A CN 201910523549 A CN201910523549 A CN 201910523549A CN 111543939 A CN111543939 A CN 111543939A
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
- A61B5/4306—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the female reproductive systems, e.g. gynaecological evaluations
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- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
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- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
- A61B8/0833—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures
- A61B8/085—Detecting organic movements or changes, e.g. tumours, cysts, swellings involving detecting or locating foreign bodies or organic structures for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
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- A61B8/40—Positioning of patients, e.g. means for holding or immobilising parts of the patient's body
- A61B8/406—Positioning of patients, e.g. means for holding or immobilising parts of the patient's body using means for diagnosing suspended breasts
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- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
- A61B8/4488—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer the transducer being a phased array
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- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
- A61B8/4494—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer characterised by the arrangement of the transducer elements
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- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
- A61B8/5261—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image combining images from different diagnostic modalities, e.g. ultrasound and X-ray
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Abstract
The invention discloses an ultrasonic detection device and a medical imaging system, comprising an ultrasonic transducer and a container for accommodating the ultrasonic transducer, wherein the container is filled with an ultrasonic coupling agent and is provided with an opening on a working surface; a transparent flexible film is laid on the surface of the opening, the flexible film is uniformly stretched towards the direction close to the ultrasonic transducer in response to the pressure difference on the two sides of the flexible film, a concave cavity capable of accommodating the detected part of the human body is generated, and the depth of the concave cavity can be adjusted to match the detected parts with different sizes; according to the invention, the flexible film is uniformly stretched by adopting pressure control, the thickness of the flexible film is gradually thinned in the stretching process, and the stretched flexible film has uniform thickness, so that the imaging effect cannot be influenced by non-negligible attenuation on illumination or acoustic signals; the flexible film effectively isolates the ultrasonic couplant and the detected part in the container, the ultrasonic couplant does not need to be replaced for different patients, and cross infection among different detected persons can not be caused.
Description
Technical Field
The invention belongs to the technical field of ultrasonic imaging, and particularly relates to an ultrasonic detection device and a medical imaging system, which are suitable for photoacoustic tomography and ultrasonic tomography of a human body convex part.
Background
Ultrasound imaging methods (including ultrasound imaging and photoacoustic imaging) have become an important means of medical diagnosis, and ultrasound detection relies on receiving ultrasound signals with an ultrasound transducer. When ultrasonic waves are incident on an interface of two different media, the larger the difference between the acoustic impedance of the two media is, the larger the reflection coefficient is, and the less energy is transmitted into the other medium by the ultrasonic waves through the interface. If there is air space between the ultrasonic transducer and the examined part or direct 'dry contact', the air space between the ultrasonic probe and the examined part can play a strong role in reflection, so that the ultrasonic wave cannot be effectively transmitted. In the ultrasonic imaging process, an ultrasonic coupling agent is used as a medium for an ultrasonic signal to reduce ultrasonic reflection and increase ultrasonic transmission. For photoacoustic tomography and ultrasound tomography for certain human tissues (e.g., breast), the transducer array is relatively large in size, so that the transducer surface is at a certain distance from the surface of human skin, and a relatively large amount of ultrasound couplant is needed; common coupling agents include water and ultrasonic coupling gel, etc., and an ultrasonic coupling agent is filled in a device provided with an ultrasonic transducer, and then the examined part of a human body is put in the ultrasonic coupling agent, so that the ultrasonic transducer receives photoacoustic or ultrasonic signals of tissues.
When different subjects are imaged with the same apparatus, cross-contamination between different subjects and contamination of the ultrasound transducer can easily occur if proper isolation and sterilization measures are not available. In order to solve the problem, a common method is to add a disinfectant into an ultrasonic coupling agent (such as water), but the disinfectant used for a long time can cause corrosion on the surface of an ultrasonic transducer and reduce the performance of ultrasonic imaging; or the ultrasonic couplant is replaced for different examinees, when the number of examinees is large, the frequent replacement of the ultrasonic couplant not only increases the waiting time, but also causes the waste of the ultrasonic couplant, and the surface of the ultrasonic transducer still has the risks of pollution and corrosion. There is also a solution in which a separating layer is placed between the examined part and the ultrasound coupling agent, for example, a separating film is directly attached to the surface of the examined part, and then the examined part is placed between the ultrasound transducers for detection, but this method has a more significant problem: the thickness of the isolation layer generally does not meet the requirements of photoacoustic or ultrasonic tomography, and illumination or acoustic signals can be attenuated during detection, so that the ultrasonic imaging effect is seriously influenced. More importantly, the isolating membrane directly attached to the examined part is easy to cause uneven thickness due to wrinkles, which affects the uniform propagation of ultrasonic or photoacoustic signals and causes the imaging quality to be reduced.
Disclosure of Invention
In view of at least one of the drawbacks and needs of the prior art, the present invention provides an ultrasonic probe and a medical imaging system, wherein a flexible film is laid on a surface of an opening of a container containing an ultrasonic transducer, and a pressure difference is formed between two sides of the flexible film to uniformly stretch the flexible film to deform the flexible film, thereby generating a concave cavity capable of accommodating a detected part of a human body, so that the detected part can be sufficiently inserted into the container filled with an ultrasonic coupling agent, and the ultrasonic transducer can receive a photoacoustic or ultrasonic signal of the detected part; the flexible film not only effectively isolates the ultrasonic couplant and the detected part in the container, but also has the most important that the thickness of the flexible film is gradually thinned in the stretching process, and the pressure difference of the flexible film has uniformity in all directions, so that the stretched flexible film has uniform thickness and the imaging effect cannot be influenced by nonuniform attenuation of signals; the ultrasonic detection device aims to solve the problems that the existing ultrasonic detection device easily causes cross infection among different examinees and can pollute an ultrasonic transducer.
In order to achieve the above object, according to one aspect of the present invention, there is provided an ultrasonic probe including an ultrasonic transducer and a container for accommodating the ultrasonic transducer, the container having an interior filled with an ultrasonic couplant and having an opening on a working surface thereof;
the surface of the opening is paved with a flexible film, the flexible film is uniformly stretched towards the direction close to the ultrasonic transducer in response to the pressure difference on the two sides of the flexible film, a concave cavity capable of accommodating the detected part is generated, and the depth of the concave cavity can be adjusted to match the detected parts with different sizes.
Preferably, in the ultrasonic detection device, the attenuation of the illumination in the visible light and near infrared region by the flexible film after the concave cavity is generated is less than 5%, and/or the thickness is less than 10 microns.
Preferably, the ultrasonic probe further comprises a moving member for generating the pressure difference, the flexible membrane is deformed to a degree depending on a moving distance of the moving member, and the depth of the concave cavity is adjusted by changing the moving distance.
Preferably, in the ultrasonic detection apparatus, the moving member is a cylinder inserted into the container, and the flexible film is deformed by adjusting an insertion length of the cylinder into the container.
Preferably, the moving part of the ultrasonic detection device comprises a cavity communicated with the container and a pull rod which is arranged in the cavity and forms a sealing fit with the inner wall of the cavity; the flexible film is deformed by adjusting the position of the pull rod in the cavity.
Preferably, the ultrasonic detection device further comprises a sealing ring arranged on the wall of the container, and the sealing ring seals the contact surface of the cylinder and the container.
Preferably, the ultrasonic detection device further comprises a film fixing member arranged around the opening, and the film fixing member fixes the flexible film on the edge of the opening to prevent the flexible film from moving in the deformation process.
Preferably, in the ultrasonic detection device, the film fixing member is a snap structure.
Preferably, the inner wall of the hollow cavity of the ultrasonic detection device is coated with an ultrasonic couplant.
Preferably, the ultrasonic detection device further comprises a power source connected with the moving part, and the power source drives the moving part to mechanically move.
According to another aspect of the present invention, there is also provided a medical imaging system, comprising an optical excitation device, an image reconstruction device, and the above-mentioned ultrasound detection device, the ultrasound detection device being electrically connected to the image reconstruction device;
the ultrasonic detection device converts the collected photoacoustic signals of the detected part into electric signals and sends the electric signals to the image reconstruction device, and the image reconstruction device reconstructs the corresponding photoacoustic signals into photoacoustic images according to the electric signals and displays the photoacoustic images.
In general, compared with the prior art, the above technical solution contemplated by the present invention can achieve the following beneficial effects:
(1) according to the ultrasonic detection device and the medical imaging system, the flexible film is stretched by adopting air pressure control, the thickness of the flexible film is gradually thinned in the stretching process, and the pressure difference of the flexible film in the ultrasonic coupling agent has uniformity in all directions, so that the stretched flexible film has uniform thickness, and the imaging effect cannot be influenced by non-negligible attenuation or non-uniform refraction on illumination or acoustic signals; the flexible film effectively isolates the ultrasonic coupling agent and the part to be detected in the container, the ultrasonic coupling agent does not need to be replaced for different patients, cross infection among different examinees cannot be caused, and the ultrasonic transducer cannot be polluted;
(2) according to the ultrasonic detection device and the medical imaging system, the flexible film is stretched by adopting air pressure control, so that the flexible film is formed in one step in the original position of the ultrasonic detection device to form a shape matched with a detected part, such as a hemispherical concave cavity, and the flexible film does not need to be transferred to an imaging instrument from other additional devices, so that the time is saved, the deformation caused by movement is avoided, and the risk of pollution caused by additional contact can be reduced;
(3) according to the ultrasonic detection device and the medical imaging system, the formed concave cavity can be matched with the shape of the detected part, so that the ultrasonic detection device and the medical imaging system accord with human engineering, and the flexible film has good touch feeling on human skin; the concave cavity not only supports human tissues to be detected (such as breasts), but also plays a role in stabilizing and fixing, and reduces motion artifacts in imaging;
(4) according to the ultrasonic detection device and the medical imaging system, the radian and the depth of the hemispherical concave cavity can be controlled through the moving tool of the moving part, so that the ultrasonic detection device and the medical imaging system have applicability to human tissues with different sizes;
(5) according to the ultrasonic detection device and the medical imaging system provided by the invention, the stretched flexible film is not only suitable for photoacoustic tomography and ultrasonic tomography, but also suitable for general photoacoustic microscopic imaging and ultrasonic imaging;
(6) according to the ultrasonic detection device and the medical imaging system, the flexible film can be selected from common food preservative films (comprising high polymer materials such as polyethylene films and polyvinyl chloride films) and is extremely low in cost, so that the flexible film is particularly suitable for one-time use, and cross infection among different examinees is avoided; and the food preservative film has good biological safety, is non-toxic and tasteless, and rejects microorganisms and bacteria, so that the safety of human skin contact is reliably guaranteed.
Drawings
Fig. 1 is a schematic structural diagram of an ultrasonic detection apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a flexible film formed in situ according to an embodiment of the present invention;
fig. 3 is a schematic structural diagram of an ultrasonic detection apparatus according to a second embodiment of the present invention;
FIG. 4 is a schematic structural diagram of a flexible film formed in situ according to a second embodiment of the present invention;
in all the figures, the same reference numerals denote the same features, in particular: 1-a container; 2-an ultrasonic coupling agent; 3-an ultrasound transducer array; 4-film fixing part; 5-a rubber sealing ring; 6-cylinder; 7-high polymer film; 8-a concave cavity; 9-the breast; 10-a cavity; 11-a pull rod.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
The invention provides an ultrasonic detection device, which comprises an ultrasonic transducer and a container for accommodating the ultrasonic transducer, wherein the container is filled with an ultrasonic couplant and is provided with an opening at the top; a flexible film is laid on the surface of the opening, the flexible film can deform in the direction close to the ultrasonic transducer in response to the pressure difference on the two sides of the flexible film, a concave cavity capable of accommodating the detected part is generated, and the depth of the concave cavity is not less than the vertical distance between the ultrasonic transducer and the opening; the examined part can be inserted into the container filled with the ultrasonic couplant through the concave cavity, so that the ultrasonic transducer can receive the photoacoustic or ultrasonic signals of the examined part; the flexible film effectively isolates the ultrasonic coupling agent and the detected part in the container, the ultrasonic coupling agent does not need to be replaced for different patients, the cross infection among different detected persons is not caused, and the ultrasonic transducer is not polluted; meanwhile, the flexible film does not influence the photoacoustic imaging result and the ultrasonic imaging result.
The structure and operation of the ultrasonic probe according to the present invention will be described in detail with reference to the accompanying drawings.
Example one
Fig. 1 is a schematic structural diagram of an ultrasonic detection device provided in this embodiment, and as shown in fig. 1, the ultrasonic detection device includes a container 1 filled with an ultrasonic coupling agent 2, an ultrasonic transducer array 3 is fixedly installed inside the container 1, in this embodiment, a plurality of ultrasonic transducers are preferentially arranged in a ring shape to form the ultrasonic transducer array 3, the ultrasonic transducer array 3 can move up and down, and each time the ultrasonic transducer array 3 moves to each position, an ultrasonic signal of a cross section of a detected part at the position is acquired, so as to implement two-dimensional imaging of a cross section, and three-dimensional imaging of the detected part is implemented by moving up and down the position of the ultrasonic transducer array 3.
The ultrasonic coupling agent 2 mainly plays a role in conducting ultrasonic signals, and in the embodiment, water is used as the coupling agent; the top of the container 1 is provided with an opening, the surface of the opening is paved with a high polymer film 7, the bottom of the container 1 is provided with a cylinder 6, and the cylinder 6 is embedded in the container 1 and can move mechanically; in order to improve the tightness, the embodiment preferably arranges a rubber sealing ring 5 on the contact surface of the container 1 and the cylinder 6, the cylinder 6 can isolate the air below and the water in the container 1, and the rubber sealing ring 5 ensures the water tightness; the cylinder 6 is made of transparent plastic in this embodiment, but other materials can be adopted for replacement; because the high polymer film 7 has certain viscosity, the high polymer film 7 can be directly paved on the surface of the opening by directly utilizing the adhesion; however, in order to better fix the high polymer thin film 7 and prevent the high polymer thin film 7 from moving in the subsequent deformation process, in this embodiment, the thin film fixing member 4 is preferably adopted to further fix the high polymer thin film 7, and the thin film fixing member 4 is a common snap structure;
after the high polymer film 7 is fixed, the container 1 becomes a closed environment, when the cylinder 6 moves downwards under the action of external force, the water pressure in the container 1 is reduced, the air pressure above the high polymer film 7 exerts force on the high polymer film 7 due to the water tightness, so that the high polymer film 7 is downwards formed into a hemispherical concave cavity 8, and the volume of the concave cavity 8 is equal to the vacancy volume caused by the downward movement of the cylinder 6. FIG. 2 is a schematic structural diagram of the flexible film provided in this embodiment after in-situ forming; the examinee can lie down at this moment, the breast 9 is placed in the hemispherical concave cavity 8, the depth of the concave cavity 8 can be controlled by the moving distance of the cylinder 6, the larger the moving distance of the cylinder 6 is, the larger the depth of the concave cavity 8 is, and therefore the examinee can be applied to parts to be examined with different sizes. In general, the depth of the concave cavity 8 may vary from a few centimeters to a few tens of centimeters.
Air gaps are formed between the formed high polymer film 7 and the skin of the examined part, so that after the high polymer film 7 is formed in situ, a proper amount of ultrasonic couplant is coated on the inner wall of the hemispherical concave cavity 8, so that after the examined part is placed in the hemispherical concave cavity 8, the ultrasonic couplant can completely fill the gaps between the skin and the high polymer film 7, and photoacoustic and ultrasonic signals can be transmitted to the surface of the ultrasonic transducer from the inside of a human body without obstruction. After the imaging of the subject is completed, the cylinder 6 is returned to the original position, the film fixing member 4 is unfastened, the polymer film 7 is removed, and then a new polymer film 7 is replaced to prepare for the next subject.
Example two
Fig. 3 is a schematic structural diagram of an ultrasonic detection device provided in the second embodiment, which is different from the first embodiment in that a syringe-like structure is used to replace the cylinder 6 in the first embodiment, and as shown in fig. 3, the syringe-like structure includes a cavity 10 communicating with the container 1, and a pull rod 11 disposed inside the cavity 10 and forming a sealing fit with the inner wall of the cavity 10; the pull rod 11 can move in the cavity 10;
after the high polymer film 7 is fixed, the container 1 forms a closed environment, when the pull rod 11 moves under the action of external force, water in the container 1 is pumped out to the cavity 10, so that the water pressure in the container 1 is reduced, air pressure above the high polymer film 7 exerts force on the high polymer film 7 due to water tightness, a hemispherical concave cavity 8 is formed downwards, and the volume of the concave cavity 8 is equal to the volume of the water entering the cavity 10. FIG. 4 is a schematic structural diagram of the flexible film provided in this embodiment after in-situ forming; at this time, the examinee can lie down, and the breast 9 is placed inside the hemispherical concave cavity 8, so that the ultrasonic transducer receives the photoacoustic or ultrasonic signal at the breast 9 for detection and imaging.
After the imaging of the examinee is completed, the control rod 11 moves in the opposite direction, the water in the cavity 10 is squeezed back into the container 1, the film fixing member 4 is unfastened, the high polymer film 7 is removed, and then a new high polymer film 7 is replaced to be used by the examinee at the next position.
In the two embodiments, the cylinder 6 or the pull rod 11 can be directly mechanically moved through manual control, in this embodiment, it is preferable to adopt automatic control of a motor, the cylinder 6 or the pull rod 11 is connected with the motor, and after the motor is started, the motor drives the cylinder 6 or the pull rod 11 to move.
The high polymer film 7 can be selected from common food preservative films (comprising high polymer materials such as polyethylene, polyvinyl chloride films and the like), has extremely low cost, is particularly suitable for one-time use, and avoids cross infection among different examinees. And the food preservative film has good biological safety, is non-toxic and tasteless, and rejects microorganisms and bacteria, so that the safety of human skin contact is reliably guaranteed.
When the device is used for photoacoustic tomography, the transmittance of the high polymer film 7 to illumination is a main consideration, and the higher the transmittance is, the weaker the attenuation to the illumination is, so that the high polymer film 7 must be a transparent film; when the device is used for ultrasonic tomography, the transmittance of the high polymer film 7 has little influence on the propagation of the acoustic signal, so that a colored flexible film can be adopted.
The thickness of the high polymer film 7 is gradually reduced in the stretching process, and the pressure difference of the high polymer film 7 in water has uniformity in all directions, so that the stretched high polymer film 7 has uniform thickness, and the imaging effect cannot be influenced by non-negligible attenuation or non-uniform refraction on illumination or acoustic signals; in this embodiment, the high polymer film 7 is stretched by air pressure control to form a hemispherical concave cavity 8, the stretched high polymer film 7 is thinner, and the thickness of the stretched high polymer film 7 in this embodiment is less than 10 micrometers, preferably less than 5 micrometers, so that the film is more transparent to light and sound signals, and the attenuation of the film to light in visible light and near infrared regions is less than 5%; for acoustic signals, the thickness of less than 10 microns is much less than the half wavelength corresponding to common ultrasound signals (center frequency typically less than 15MHz) and is therefore also transparent for acoustic signals; therefore, the stretched polymer film 7 of the present embodiment does not attenuate light or acoustic signals, and the device is suitable for photoacoustic imaging and ultrasonic imaging of human tissues.
The high polymer film 7 is stretched by adopting air pressure control, so that the high polymer film 7 is formed into a perfect hemispherical concave cavity in the original position of the device at one step without being transferred to an imaging instrument from other additional devices, thereby saving time, avoiding deformation caused by movement and reducing the risk of pollution caused by additional contact; in addition, the hemispherical concave cavity is matched with the shape of human breast tissue, so that the human breast tissue conforms to human engineering, and the elastic film has good touch feeling on human skin; the formed hemispherical concave cavity not only supports human tissues to be detected (such as breasts), but also plays a role in stabilizing and fixing, and reduces motion artifacts in imaging. The arc and depth of the concave cavity can be controlled by the position of the cylinder, so that the hollow cavity has applicability to human tissues of different sizes.
EXAMPLE III
The embodiment provides a medical imaging system, which comprises an optical excitation device, an image reconstruction device and an ultrasonic detection device in the first embodiment or the second embodiment, wherein the ultrasonic detection device is electrically connected with the image reconstruction device;
the optical excitation device is mainly used for emitting ultrasonic or photoacoustic signals and irradiating the ultrasonic or photoacoustic signals to a detected part; ultrasonic or photoacoustic signals are absorbed by the examined part and converted into transient heat energy, and then ultrasonic waves are emitted due to thermoelastic expansion;
the ultrasonic detection device collects ultrasonic signals of a detected part, converts the ultrasonic signals into electric signals and sends the electric signals to the image reconstruction device, and the image reconstruction device reconstructs the corresponding ultrasonic signals into photoacoustic images according to the electric signals to obtain and display the photoacoustic images of the detected part.
According to the ultrasonic detection device and the medical imaging system, the flexible film is stretched by adopting air pressure control, the thickness of the flexible film is gradually reduced in the stretching process, and the pressure difference of the flexible film in the ultrasonic couplant has uniformity in all directions, so that the stretched flexible film has uniform thickness, and the imaging effect cannot be influenced by attenuation of illumination or acoustic signals; and the flexible film effectively isolates the ultrasonic coupling agent and the detected part in the container, the ultrasonic coupling agent does not need to be replaced for different patients, the cross infection among different detected persons can not be caused, the ultrasonic transducer can not be polluted, the service life of the device is prolonged, and the cost is saved.
It will be understood by those skilled in the art that the foregoing is only a preferred embodiment of the present invention, and is not intended to limit the invention, and that any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. An ultrasonic detection device comprises an ultrasonic transducer and a container for accommodating the ultrasonic transducer, wherein the container is filled with an ultrasonic couplant and is provided with an opening on a working surface; it is characterized in that the preparation method is characterized in that,
the surface of the opening is paved with a flexible film, the flexible film can be uniformly stretched towards the direction close to the ultrasonic transducer in response to the pressure difference on the two sides of the flexible film, a concave cavity capable of containing the detected part is generated, and the depth of the concave cavity can be adjusted to match the detected parts with different sizes.
2. The ultrasonic detection device of claim 1, wherein the flexible film after stretching to create the recessed cavity attenuates light in the visible and near infrared regions by less than 5% and/or has a thickness of less than 10 microns.
3. The ultrasonic probe of claim 1 or 2, further comprising a moving member for generating the pressure difference, wherein the depth of the recessed cavity is adjusted by changing a moving distance of the moving member.
4. The ultrasonic detection device of claim 3, wherein the moving member is a cylinder inserted into the container, and the flexible film is deformed by adjusting the insertion length of the cylinder into the container.
5. The ultrasonic detection device of claim 4, wherein the moving member comprises a chamber in communication with the container and a pull rod disposed within the chamber and in sealing engagement with an inner wall of the chamber; the flexible film is deformed by adjusting the position of the pull rod in the cavity.
6. The ultrasonic detection device of claim 5, further comprising a sealing ring disposed on the wall of the vessel, the sealing ring sealing the interface of the cartridge and the vessel.
7. The ultrasonic detection device of claim 5 or 6, further comprising a membrane holder disposed around the opening, the membrane holder holding the flexible membrane at the edge of the opening to prevent the flexible membrane from moving during deformation.
8. The ultrasound probe of claim 7, wherein the inner walls of the recessed cavity are coated with an ultrasound couplant to fill an air gap between the flexible membrane and the site under examination.
9. The ultrasonic detection device of claim 8, further comprising a power source coupled to the moving member, the power source mechanically moving the moving member.
10. A medical imaging system comprising optical excitation means and image reconstruction means, and further comprising ultrasound detection means according to any of claims 1-9, said ultrasound detection means being connected to the image reconstruction means.
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