CN111536013A

CN111536013A - Method for implementing micro-flow control by audio input

Info

Publication number: CN111536013A
Application number: CN202010360155.1A
Authority: CN
Inventors: 彭兴跃
Original assignee: Xiamen Qiyue Electronic Technology Co ltd
Current assignee: Xiamen Qiyue Electronic Technology Co ltd
Priority date: 2020-04-30
Filing date: 2020-04-30
Publication date: 2020-08-14
Anticipated expiration: 2040-04-30
Also published as: CN111536013B

Abstract

The invention discloses a method for realizing micro-flow control by audio input, which comprises a spherical magneton with a definite NS pole, a rectangular magnetic sheet with a definite NS pole and a driving coil, wherein the magnetic sheet is provided with a magnetic core; the spherical magneton is put into a microchip with a circulation channel, the driving coil and the rectangular magnet piece are arranged outside the circulation channel, and the driving coil is connected with external audio output equipment through an audio cable. Rearranging music chapters input by audio, loading the music chapters by using music editing software, and outputting a square wave file; obtaining a new square wave file by changing scales or reducing the playing speed; copy to Mp3 player; the micro-flow control is achieved by Mp3 and outputting the audio signal directly to the drive coil. The vibrator pump microfluidic system is suitable for a circulating system, and fluid in a channel circulates among cells or tissues on a channel network without any interference from the outside; all recordings of square waves, string music or symphony orchestra can drive the liquid in the chip.

Description

Method for implementing micro-flow control by audio input

Technical Field

The invention relates to the field of microfluidics, in particular to a method for realizing microflow control by audio input.

Background

The micro-fluidic chip adopts a micro-electro-mechanical processing technology similar to a semiconductor to construct a micro-channel system on the chip, transfers the experiment and analysis process to a chip structure consisting of a path and a small liquid-phase chamber which are mutually connected, loads a biological sample and a reaction liquid, and drives the flow of a buffer solution in the chip by adopting methods such as a micro-mechanical pump, an electric hydraulic pump, electroosmosis flow and the like to form a micro-channel so as to perform one or continuous multiple reactions on the chip.

There are many different ways of classifying micropumps: according to the existence of the movable valve plate, the valve-type micro pump and the valveless micro pump can be divided; the valved micropump generally works by utilizing the periodic change of the cavity volume and a one-way valve, has a simple principle, is mature in manufacturing process and easy to control, and is the mainstream of the prior application. However, because of the existence of mechanical parts such as the valve plate and the like in the pump body, the problems of fatigue and service life of the valve plate are always difficult to be troubled by researchers, and the application range of the valve plate is greatly limited; further, the process and process accuracy of these mechanically movable parts limit further miniaturization of valved micropumps and do not meet the technological requirements of microfluidic chips that have been rapidly developed in recent years. Compared with a valve micropump, the valveless micropump has unique development advantages and wide application prospect due to the novel principle, relatively simple structure, low requirement on manufacturing process and suitability for miniaturization.

The micropump may be classified into a piezoelectric type, an electrostatic type, a pneumatic type, a thermal driving type, and the like according to a driving method. The driving mode of the existing valveless micropump is too complex and large in power consumption, and is easily limited by a use scene.

Disclosure of Invention

The invention provides a method for realizing micro-flow control by audio input, which is used for realizing the simplest driving structure of micro-fluid and reducing power consumption.

The technical problem solved by the invention can be realized by adopting the following technical scheme:

a method for realizing micro-flow control by audio input is characterized in that: comprises a spherical magnet with a definite NS pole, a rectangular magnet piece with a definite NS pole and a driving coil; the spherical magnetons are placed in a microchip with a circulation channel, the driving coil and the rectangular magnet piece are arranged outside the circulation channel, and the rectangular magnet piece is flatly placed in an inner ring surface of the driving coil; the driving coil is connected with external audio output equipment through an audio cable, and audio input by the audio cable is square wave input.

Preferably, the step of implementing the micro-stream control by the audio input comprises: the method comprises the following steps: rearranging the music chapters of the audio input into a left music chapter and a right music chapter; step two: loading the arranged music chapters in the step one by using music editing software, and outputting a square wave file; step three: obtaining a square wave file capable of driving the vibrator to vibrate by changing scales or reducing playing speed; step five: copying the file obtained in the step four into an Mp3 player; step six: the Mp3 plays a file and outputs an audio signal directly to the driving coil through the audio cable.

The oscillator pump micro-fluidic system is particularly suitable for a circulating system, and fluid in the channel circulates among cells or tissues on a channel network without any interference from the outside; all recordings of square waves, string music or symphony orchestra can drive the liquid in the chip. With the channels open, drugs, cells or any other solid or liquid substance can be easily accessed. The micro-fluidic system of the vibrator pump can be used for a closed or hidden flow channel and is optimal when used under an open channel. Because the spherical magneton has small volume and does not occupy liquid, the total volume of the circulating liquid is always kept unchanged even if the total size is minimum, and the spherical magneton has good application prospect.

Drawings

Fig. 1 is a schematic diagram of a vibrator pump assembly.

Fig. 2 is a schematic structural diagram of a double-vibrator pump audio driving system.

Fig. 3 is a schematic diagram of the audio driving system of the single-vibrator pump.

FIG. 4 is a schematic diagram of different audio inputs of embodiment 2, and FIG. 4a shows a left and right music chapters after being changed; FIG. 4b is a square waveform of the audio conversion; FIG. 4c is the waveform after pitch reduction; FIG. 4d is a graph of velocity versus note; FIGS. 4e and f are graphs showing the relationship between velocity and note in the case of string music with different sound velocities; FIG. 4g is a schematic diagram of a programming process.

In the figure, 1 spherical magnet, 2 rectangular magnet pieces, 3 driving coils, 4 circulation channels and 5 audio cables.

Detailed Description

The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.

The valveless micro-flow pump which utilizes the vibrator to drive the micro-fluid, namely a vibrator pump, is the simplest micro-flow pump, and positive pressure is generated in the axial direction of vibration through the vibrator which vibrates in a localized mode, and negative pressure is generated in all directions on a plane which is orthogonal to the vibration axial line of the vibrator, so that the fluid is driven to move.

Fig. 1 to 4 are preferred embodiments of the present invention, and the simplest vibrator pump is shown in fig. 1, and includes a spherical magnet 1 having a definite NS pole, a rectangular magnet piece 2 having a definite NS pole, and a driving coil 3; the spherical magneton 1 is placed in the fluid containing cavity, and the rectangular magnet piece 2 and the driving coil 3 are used as driving main bodies and are arranged outside the fluid containing cavity. The spherical magneton 1 can be adsorbed on the nearest inner wall of the cavity by the rectangular magnet piece 2, and the spherical magneton 1 can be suspended in the fluid when the buoyancy is fixed. The rectangular magnet piece 2 is laid on the inner ring surface of the driving coil 3, and the driving coil 3 has the capability of driving the rectangular magnet 2 to rotate or swing. Fig. 3 is a schematic physical diagram of an embodiment of the present invention, a spherical magnet 1, a rectangular magnet piece 2 and a driving coil 3 are all purchased from the market, in this embodiment, the spherical magnet 1 with a diameter of 2mm, the rectangular magnet piece 2 with a length of 4.5mm and the driving coil 3 with an inner ring width of 5mm and a length of 3mm are adopted, the rectangular magnet piece 2 is placed in the driving coil 3, the overall size of the whole experimental device does not exceed 1cm, and the volume of the experimental device is greatly reduced compared with that of other micropumps.

After the driving coil 3 is electrified, the positions of the N pole and the S pole of the rectangular magnet piece 2 are changed by adjusting the current, so that the position of the spherical magnet 1 is changed, and the diameter of the spherical magnet 1 is 2 mm.

The input power of the vibrator pump is as follows:

the spherical magneton 1 rolls back and forth. Considering that the ball rolls without resistance and friction, its translation and rotation require energy, indicated as Et and Er respectively. The sum of Et and Er is the minimum input power of the microfluidic chip (Em).

E_m＝E_t+E_r(1)

For a rolling spherical magneton 1 (radius r and density), the energy calculation formula is as follows:

wherein m is mass, I is moment of inertia, v is minimum translation speed of the microbeads, and omega is rotation speed thereof.

For a microfluidic chip, f denotes its frequency (in hertz) and a denotes its amplitude distance (in meters). The total translation distance in one second is 2fA

v＝2fA (4)

In one vibration period, the spherical magnet 1 must be activated twice, and the spherical magnet 1 must be deactivated twice (four times in total). Within 1 second of the frequency f, a total energy (Etotal 4fEm) is obtained, which is the minimum power consumption (Pbeadpump) of the single micro-flow pump.

For a 2mm iron oscillator pump, Pbeadpump is 0 when f is 25hz and a is 5 mm. 144mW, according to equation 7. Most Mp3 players or other modern mobile devices (e.g., cell phones or tablets) have over 1 megawatt of headphone or headphone music output (e.g., iPhone6, 3.0-44.0 megawatts of audio output). Thus, it can be used directly to drive the oscillator pump without any additional signal amplification. For a 3mW audio output device, there is 20 times more room to handle any electrical and mechanical power losses.

The minimum power consumption (height of h, width of w, thickness of L, and density) of the rectangular magnet piece was calculated as follows.

If the amplitude of the wobble is an angle (in radians), the minimum ω can be calculated by equation 10.

ω_magnetbar＝2·A_anglef (10)

For a rectangular magnet piece (h 3.5mm, w 4.5mm, L1 mm, angle a pi/2, f 25Hz, 7.87g/cm3), Pmagnetbar is 0. 104mW, according to equation 11, can be derived

P_system＝P_magnetbar+P_beadpump＝0.104+0.144＝0.248(mW) (12)

If four spherical magnetons 1 work simultaneously, only 0.992mW of minimum power consumption is needed.

Because only 0.248mw (minimum value) is needed by one oscillator pump, the invention adopts the audio input current to drive the oscillator pump to move, and the micro-fluidic chip is manufactured. The chip is equipped with inside circulation channel 4, puts into circulation channel 4 with spherical magnon 1 in, and rectangle magnet piece 2 and drive coil 3 set up outside circulation channel 4, connect outside audio output equipment through audio cable 5.

Example 1:

the thickness of the chip of the double-pump micro-fluidic system is 4mm, a double-pump plastic driver in the shape of a hand mirror is installed, the hand mirror is in the shape of a hand mirror and is provided with a 3.5mm audio jack, and the micro-fluidic chip can work by inserting a 3.5mm audio cable into any audio output of external audio playing equipment such as a mobile phone, a keyboard or other portable music players. The left or right electric audio signal of the external audio playing device is respectively connected with the two vibrator pumps through the 3.5mm cable 5, the two vibrator pumps are used for replacing the two earphones, and the sound waves of music played by the two earphones enable the two vibrator pumps to drive the fluid in the circulating channel 4.

In order to ensure the accurate characteristics of the pump, a music file played by an external player is changed into a square wave file, and the micro-fluidic system of the vibrator pump does not need to be manufactured precisely, does not need high-level engineering, does not need unique materials and only needs one spherical magneton 1. The micro-fluidic system of the vibrator pump does not need special driving equipment, and only needs one Mp3 player. Traffic, whether on open or closed channels, is controlled by Mp3 players. The dead volume of this pump is zero because the spherical magnet 1 is only a solid sphere. The micro-fluidic system of the vibrator pump does not need special conditions for working, only needs fluidity, and has the service life only limited to the decay of the spherical magneton 1 and the rectangular magnet piece 2.

The number and the placement positions of the spherical magnetons 1 can be selected according to the shapes of the circulating channels 4 and the fluid motion, and the driving coils 3 and the rectangular magnet pieces 2 are correspondingly placed outside the spherical magnetons 1 one by one, as shown in fig. 3, the micro-flow system of the single-vibrator pump is provided.

Example 2: the fifth reverberation of bazedoxifene was used to control microfluidics.

A conventional Mp3 player outputs a left channel and a right channel, and the bazedoxifene fifth symphony has 15 instruments, and the first music is rearranged into two parts, a left music and a right music (fig. 4 a). The aligned score is loaded using music editing software (Cubase, steinberg media technologies) and a square wave file is output (fig. 4 b). This file can be played on an Mp3 player, but it is too frequent to drive the bead pump. By transposing 5 octaves or 36vb, lowering 1/5 playing speed results in one file (fig. 4c) and copies the file to the Mp3 player. Mp3 plays the file and outputs the audio signal directly to the driving coil 3, where the audio L connects to the left coil and the audio R connects to the right coil, controlling the left and right spherical magnetons 1, respectively. The flow rates of the left and right channels can be calculated by external camera recordings (fig. 4 d).

With a square wave we have a sharp note corresponding to the velocity peak. Whether the chip is open or closed, the square wave can effectively control the movement of fluid, whether channels are present or not, and whether one or more pumps are present or not. After 32 video accelerations, we can playback and normal real symphony speeds to detect the response of the pump to the music notes. If it is changed to string music or even to real symphony orchestra recordings, the one-to-one relationship between notes and velocity peaks is destroyed (fig. 4e and f) because of the complex waveform of string music (see left insets of fig. 4d, e and f). The complex wave pattern disturbs the operation of the spherical magneton 1 and is difficult to predict. It is therefore preferable to use square wave drive if precise control is required.

The fifth reverberation of the bazedoxifene is rearranged into two stereo square wave segments for microflow control. The first 19 of the 638 measures (fig. 4a) were 14s long (fig. 4 b). After the sound is prolonged to 448s (1/32 speed), the pitch is 36vb lower than the original pitch, and the waveform is unchanged (see the insets of fig. 4b, c and d); its frequency span can be used for pumping (fig. 4 c). These flows show a strong relationship to notes (fig. 4d), with peaks matching the four-tone motive noted by bazedoxifene. The waveform becomes complex (see waveform in fig. 4e) after the square wave is replaced with string music, and the peak matching the note almost disappears (fig. 4 e). If we use a real symphony recording, the highly complex waves still drive the flow, but do not show any relationship to the notes (fig. 4 f). Instead of making one music file to control the stream, individual sound units are more suitable for stream programming (fig. 4 g). A library of different frequencies and different durations may be created and the required files copied from the library to the Mp3 player. After a playlist is made, setting the loop sentence as [ all play ]; mp3 will automatically execute the microfluidic program.

Fig. 4g shows how to edit a playlist and program the microflows using an Mp3 player. First, music files of different frequencies (hertz or notes) and different durations (seconds, minutes or hours) in the library (left column of fig. 4g) are required. The frequency span and duration are selected as desired. If we need to write a flow as shown in FIG. 4g, we can copy files from the library and rename them with sequence numbers (middle column in FIG. 4 g). Here we can see that the procedure is: 01 play for C-210 seconds; 02 playing for C-210 seconds; 03 playing for G-210 seconds; 04 playing soundless for 30 seconds; 05 playing for C-310 seconds; 06 playing soundless for 30 seconds; 07 goes to 01 (full play). The relative speeds of the programs were: 1(20 s); 1.5(10 s); 0 (30); 0.5(10 s); 0(30 s); do loops. After the file list editing is completed, the spherical magnet 1 is put in the circular channel 4, the file is copied into the Mp3 player, the playing is started, and the fluid in the channel changes the movement according to the program.

The micro-fluidic system of the vibrator pump is particularly suitable for a circulating system, and liquid can be pumped out after a spherical magneton 1 is placed in a circulating channel 4. The fluid in the channel circulates among cells or tissues on the channel network without any interference from the outside; all recordings of square waves, string music or symphony orchestra can drive the liquid in the chip. With the channels open, drugs, cells or any other solid or liquid substance can be easily accessed. The micro-fluidic system of the vibrator pump can be used for a closed or hidden flow channel and is optimal when used under an open channel. Because the volume of the spherical magneton is small, the spherical magneton does not occupy liquid, and even if the total size is minimum, the total volume of the circulating liquid is always kept unchanged. For 2mm spherical magnetons 1, a circulating system can be formed by less than one tenth of milliliter of liquid, and the system has good application prospect.

The above description is only a preferred embodiment of the present invention, and is not intended to limit the technical scope of the present invention, so that any minor modifications, equivalent changes and modifications made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the present invention.

Claims

1. A method for realizing micro-flow control by audio input is characterized in that: comprises a spherical magnet with a definite NS pole, a rectangular magnet piece with a definite NS pole and a driving coil; the spherical magnetons are placed in a microchip with a circulation channel, the driving coil and the rectangular magnet piece are arranged outside the circulation channel, and the rectangular magnet piece is flatly placed in an inner ring surface of the driving coil; the driving coil is connected with external audio output equipment through an audio cable, and audio input by the audio cable is square wave input.

2. The method for implementing micro-stream control of audio input as claimed in claim 1, wherein: the step of implementing the micro-stream control by the audio input comprises:

the method comprises the following steps: rearranging the music chapters of the audio input into a left music chapter and a right music chapter;

step two: loading the arranged music chapters in the step one by using music editing software, and outputting a square wave file;

step three: obtaining a square wave file capable of driving the vibrator to vibrate by changing scales or reducing playing speed;

step five: copying the file obtained in the step four into an Mp3 player;

step six: the Mp3 plays a file and outputs an audio signal directly to the driving coil through the audio cable.