CN111534769A - Heat treatment method for improving mechanical property and biological function stability of magnesium alloy - Google Patents
Heat treatment method for improving mechanical property and biological function stability of magnesium alloy Download PDFInfo
- Publication number
- CN111534769A CN111534769A CN202010140864.9A CN202010140864A CN111534769A CN 111534769 A CN111534769 A CN 111534769A CN 202010140864 A CN202010140864 A CN 202010140864A CN 111534769 A CN111534769 A CN 111534769A
- Authority
- CN
- China
- Prior art keywords
- magnesium alloy
- interference
- polishing
- improving
- heat treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/06—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B24—GRINDING; POLISHING
- B24B—MACHINES, DEVICES, OR PROCESSES FOR GRINDING OR POLISHING; DRESSING OR CONDITIONING OF ABRADING SURFACES; FEEDING OF GRINDING, POLISHING, OR LAPPING AGENTS
- B24B27/00—Other grinding machines or devices
- B24B27/033—Other grinding machines or devices for grinding a surface for cleaning purposes, e.g. for descaling or for grinding off flaws in the surface
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/02—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working in inert or controlled atmosphere or vacuum
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Physics & Mathematics (AREA)
- Thermal Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a heat treatment method for improving the mechanical property and biological function stability of magnesium alloy, which comprises the following steps: (1) completely annealing the original cold-drawn magnesium alloy AZ31 in an interference-free atmosphere; (2) polishing the surface of the magnesium alloy AZ31 obtained in the step (1) by using water sand paper, eliminating an original oxide layer, and keeping and improving the surface smoothness; (3) heating the magnesium alloy obtained in the step (2) by using inert gas or vacuum interference-free atmosphere, heating the magnesium alloy to 300-400 ℃, and then preserving heat for 3-5 hours; (4) and (4) completing complete annealing treatment of the magnesium alloy obtained in the step (3) in an interference-free atmosphere, and cooling the magnesium alloy to room temperature along with a furnace to obtain an isometric crystal structure with uniform and isotropic structure. The magnesium alloy AZ31 prepared by the method has a good tissue structure: the grain size is about 16 microns, the hardness is about 73HV, the coating has relative stability and good corrosion resistance, has good binding performance with corresponding polypeptide, and can maintain good biological functionality, such as antibacterial property and the like, of the coating.
Description
Technical Field
The invention relates to a metal treatment method, in particular to a heat treatment method for improving the mechanical property and the biological function stability of magnesium alloy.
Background
With the development of human society and the increase of human activities, the damage of human bone tissues and hard tissues is more and more frequent, and thus the requirements for fixing, repairing and replacing corresponding bone tissues as well as biomaterials are more and more demanding.
The traditional bone fixing and replacing materials such as titanium alloy, stainless steel and other metal materials have large difference with the elastic modulus of human bone tissues and the mechanical property of human bones, so once the bone fixing and replacing materials are implanted into a human body, a plurality of problems are easy to occur: stress shielding, localized PH changes due to the release of metal ions, and thus, an intermediate infectious or inflammatory response. Thus, biocompatibility is poor and adaptation to the bone healing process is difficult. The polymer material has poor mechanical properties, particularly poor plasticity, toughness and radial mechanical properties, so that the polymer material cannot be widely applied as a bone substitute material.
As a typical light alloy, the magnesium alloy AZ31 has almost the same elastic modulus with human bones, so the magnesium alloy AZ31 is close to the mechanical properties of the human bones and is an ideal human bone substitute material. In addition, magnesium is an essential component for human metabolism and biological reaction, and magnesium has a good promoting effect on bone growth and strengthening through the combination with osteoblasts. Magnesium has good biocompatibility as a bone substitute material.
However, because magnesium is active in chemical property, in the human body environment, due to the existence of a plurality of ions, the degradation rate of the magnesium and magnesium alloy AZ31 transplantation material is fast, and further the pH value of the local body fluid environment is obviously increased, so that alkalosis can be caused, local inflammatory reaction can be caused, and cells can be dead. Therefore, the control of the degradation rate of the magnesium alloy AZ31 in vivo becomes a key problem for the application of the magnesium alloy AZ31 as a bone grafting material.
In order to solve the problem of too rapid degradation of the magnesium alloy AZ31 in vivo, many methods have been used to improve the corrosion resistance of magnesium, and various physical and chemical methods have been used to strengthen the surface. At present, in order to make the material have more biological activity and biocompatibility, various coatings with biological functions are generated; however, due to the defects of the magnesium alloy AZ31, the functionality of the coating on the surface of the material is reduced, the activity of the coating is reduced, and the use of the material is influenced.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a heat treatment method for improving the mechanical property and biological function stability of the magnesium alloy, and the magnesium alloy added by the method has a good tissue structure, has good binding property with corresponding polypeptide, and can maintain good biological functions of a coating, such as antibacterial property and the like.
In order to solve the technical problems, the invention adopts the following technical means:
the heat treatment method for improving the mechanical property and the biological function stability of the magnesium alloy comprises the following steps:
(1) completely annealing the original cold-drawn magnesium alloy AZ31 in an interference-free atmosphere with original processing stress eliminated and special structure texture eliminated;
(2) polishing the surface of the magnesium alloy AZ31 obtained in the step (1) by using water sand paper, eliminating an original oxide layer, and keeping and improving the surface smoothness;
(3) heating the magnesium alloy AZ31 obtained in the step (2) by using inert gas or vacuum to manufacture an interference-free atmosphere, heating the magnesium alloy AZ31 to 330-350 ℃ in the inert gas atmosphere, and then preserving heat for 3-4 hours;
(4) and (4) completing complete annealing treatment on the magnesium alloy AZ31 obtained in the step (3) by utilizing an interference-free atmosphere of inert gas, and cooling to room temperature along with a furnace to obtain an isometric crystal structure with uniform and isotropic structure.
The magnesium alloy AZ31 prepared by the method has a good tissue structure: the grain size is about 16 microns, the hardness is about 73HV, the polypeptide has good binding performance with the corresponding polypeptide, and good biological functionality, such as antibacterial property and the like, of the coating can be maintained.
The further preferred technical scheme is as follows:
the surface of the magnesium alloy AZ31 is ground by water sand paper, including primary grinding and polishing; the primary grinding is carried out by using water sand paper with 400 meshes, and grinding is carried out for 1-3 minutes, so that an original oxide layer is eliminated; then immediately polishing, wherein the polishing is carried out by using water sand paper 1200-2400 meshes, and the surface finish of the magnesium alloy AZ31 is kept for 2-5 minutes.
The polishing mode is helpful for removing the oxide layer on the surface of the magnesium alloy AZ31, and the surface is clean and has good smoothness.
The primary grinding is carried out according to one direction, the oxide layer can be effectively removed according to the force requirement, and the primary grinding is carried out until the dark oxide layer is completely removed from the surface of the magnesium alloy AZ31, so that silver-white magnesium metal is generated; the grinding direction in the polishing process is vertical to the primary grinding direction, and the force is smaller than that of primary grinding until no obvious scratch is formed on the surface of the magnesium alloy AZ 31.
The polishing mode is helpful for removing the oxide layer on the surface of the magnesium alloy AZ31, and the surface is clean and has good smoothness.
Drawings
FIG. 1 is a schematic view of a non-interference atmosphere complete annealing.
FIG. 2 is a comparison of the structure of AZ31 magnesium alloy AZ31 after annealing compared to the structure of the original drawn AZ31 magnesium alloy AZ31, in which (a) the structure of the untreated cold drawn AZ31 magnesium alloy AZ 31; (b) and the AZ31 magnesium alloy AZ31 structure is completely annealed in a non-interference atmosphere.
Fig. 3 is a schematic structural diagram of a bone nail made of magnesium alloy according to the method.
FIG. 4 is a comparison graph of the antibacterial reaction of the annealed AZ31 magnesium alloy AZ31 after being combined with small molecule polypeptide, wherein, the graph A is a 24-hour antibacterial reaction graph of a magnesium alloy AZ31 chelated small molecule peptide F3 sample; FIG. B is a 48-hour bacteriostatic reaction diagram of a magnesium alloy AZ31 chelated small molecule peptide F3 sample; the graph C is a 24-hour bacteriostatic reaction graph of an original cold-drawn peptide AZ31 chelated small molecule peptide F3 sample; and the graph D is a 48-hour bacteriostatic reaction graph of an original cold-drawn peptide AZ31 chelated small-molecule peptide F3 sample.
FIG. 5 is a schematic structural diagram of a sample obtained by an in-vitro corrosion experiment made of the magnesium alloy according to the method.
FIG. 6 shows the pH change of the samples of AZ31 magnesium alloy after annealing, cold-extruded magnesium alloy and pure magnesium alloy after 5 days of in vitro corrosion test.
FIG. 7 shows the weight values of samples of AZ31 magnesium alloy after annealing, cold-extruded magnesium alloy and pure magnesium alloy after annealing after 5 days of in vitro corrosion test.
FIG. 8 is the surface topography of the sample after 5 days of in vitro corrosion testing. A: the surface appearance of the AZ31 sample before in-vitro corrosion is cold-drawn; b, surface appearance of the AZ31 sample before in-vitro corrosion after annealing; c: the surface appearance of the AZ31 sample after being corroded for 120 hours in vitro is cold drawn; and D, the surface appearance of the AZ31 sample after annealing and in-vitro corrosion for 120 hours.
Detailed Description
The present invention will be further described with reference to the following examples.
Referring to fig. 1 to 4, the heat treatment method for improving the mechanical property and the biological function stability of the magnesium alloy according to the present invention includes the following steps:
(1) completely annealing the original cold-drawn magnesium alloy AZ31 in an interference-free atmosphere with original processing stress eliminated and special structure texture eliminated;
(2) polishing the surface of the magnesium alloy AZ31 obtained in the step (1) by using water sand paper, eliminating an original oxide layer, and keeping and improving the surface smoothness; the surface of the magnesium alloy AZ31 is ground by water sand paper, including primary grinding and polishing; the primary grinding is carried out by using water sand paper with 400 meshes, and grinding is carried out for 1-3 minutes, so that an original oxide layer is eliminated; then immediately polishing, wherein the polishing is carried out by using water sand paper 1200-2400 meshes, and the surface finish of the magnesium alloy AZ31 is kept for 2-5 minutes; the primary grinding is carried out according to one direction, the oxide layer can be effectively removed according to the force requirement, and the primary grinding is carried out until the dark oxide layer is completely removed from the surface of the magnesium alloy AZ31, so that silver-white magnesium metal is generated; the grinding direction in the polishing process is vertical to the primary grinding direction, and the force is smaller than that of primary grinding until no obvious scratch is formed on the surface of the magnesium alloy AZ 31;
(3) heating the magnesium alloy AZ31 obtained in the step (2) by using inert gas or vacuum to manufacture an interference-free atmosphere, heating the magnesium alloy AZ31 to 330-350 ℃ in the inert gas atmosphere, and then preserving heat for 3-5 hours, wherein the 3-5 hours are t1-t2 time in the picture 1;
(4) and (4) completing complete annealing treatment on the magnesium alloy AZ31 obtained in the step (3) by utilizing an interference-free atmosphere of inert gas, and cooling to room temperature along with a furnace to obtain an isometric crystal structure with uniform and isotropic structure.
Metallographic structure observation was performed by a field emission scanning electron microscope, and the microstructure of AZ31 before and after heat treatment was compared. The grain size of the AZ31 magnesium alloy AZ31 after annealing was 15.8 microns and the grain size of the original cold drawn magnesium alloy AZ31 was 9.2 microns. The hardness of AZ31 was measured by a Vickers microhardness tester to compare the change in Vickers hardness before and after heat treatment. The Vickers hardness of untreated AZ31 was 83.9HV, while that of AZ31 after complete annealing in a non-interfering atmosphere was 72.8 HV.
The bacteriostasis comparative experiment comprises the following steps:
(1) the original cold-drawn magnesium alloy AZ31 and the AZ31 of the method are made into small-size bone nails with the diameter of 0.5mm and the length of 2mm, and the size tolerance is +/-0.005 mm;
(2) combining two small-size bone nails processed by two alloys with polypeptide F3 of a small molecule through a chelation reaction, and respectively generating a layer of small peptide F3 coating on the surface of each bone nail;
(3) two magnesium alloy AZ31 samples after chelation reaction were subjected to a 48-hour bacteriostatic test of drug-resistant Staphylococcus aureus to observe the antibacterial properties of the two materials, and the results are shown in the following table:
table 1: and (5) comparing the bacteriostatic effect.
(4) The analysis leads to the experimental conclusion: comparing the experimental results, it can be seen that: compared with magnesium alloy AZ31 chelated with small peptide F3 in a cold-drawn state, the magnesium alloy AZ31 sample subjected to interference-free ambient complete annealing treatment has more stable and durable antibacterial performance after being chelated with polypeptide F3: the antibacterial agent can keep good antibacterial performance against drug-resistant staphylococcus aureus within 48 hours; and after the cold-drawn AZ31 is chelated with the polypeptide F3, the antibacterial effect on the drug-resistant staphylococcus aureus is completely lost after 48 hours.
(II) in vitro corrosion comparison experiment as follows:
(1) the original cold-drawn magnesium alloy AZ31 and the AZ31 prepared by the method are made into small-size magnesium sheets with the diameter of 4.4mm and the thickness of 2mm, and the dimensional tolerance is +/-0.002 mm;
(2) putting the two metal samples into a DMEM (Dulbecco's Modified Eagle Medium) high-sugar culture Medium, and carrying out an in-vitro corrosion resistance test for 120 hours in a constant-temperature incubator at 37 ℃;
(3) in the in vitro corrosion process, the weight of the sample and the pH value of the DMEM medium are detected regularly. The specific observation contents and steps and observation results are as follows:
table 2: comparison of in vitro Corrosion test results
(4) After the in vitro corrosion test was completed, the surface topography of the two samples was observed using SEM.
(5) The analysis leads to the experimental conclusion: comparing the experimental results, it can be seen that: compared with the magnesium alloy AZ31 in a cold-drawn state, the magnesium alloy AZ31 sample subjected to interference-free ambient complete annealing treatment has more stable and durable corrosion resistance: can be in DMEM within 120 hours; and the cold-drawn AZ31 has accelerated corrosion after 48 hours, accelerated sample weight loss and no corrosion resistance to DMEM. Through observation of surface morphology, when the corrosion is 120 hours, a large amount of obvious laminar or scaly peeled objects are formed on the surface of the magnesium alloy AZ31 in a cold-drawn state, and the surface corrosion is obvious; and the AZ31 surface which is completely annealed in an interference-free atmosphere has no obvious layered or scaly exfoliation, and the surface is kept relatively intact.
The method of the embodiment has the advantages of simple process, convenient operation and strong feasibility, and the formed new material is stable and is combined with other materials to form a stable structure; the activity of the binding product can be maintained and strengthened; low energy consumption, easy production, short period, easy industrialization and no pollution to the environment.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the scope of the present invention, which is defined in the appended claims.
Claims (3)
1. The heat treatment method for improving the mechanical property and the biological function stability of the magnesium alloy is characterized by comprising the following steps of:
(1) completely annealing the original cold-drawn magnesium alloy AZ31 in an interference-free atmosphere with original processing stress eliminated and special structure texture eliminated;
(2) polishing the surface of the magnesium alloy AZ31 obtained in the step (1) by using water sand paper, eliminating an original oxide layer, and keeping and improving the surface smoothness;
(3) heating the magnesium alloy AZ31 obtained in the step (2) by using inert gas or vacuum to manufacture an interference-free atmosphere, heating the magnesium alloy AZ31 to 300-350 ℃ in the inert gas atmosphere, and then preserving heat for 3-4 hours;
(4) and (4) completing complete annealing treatment on the magnesium alloy AZ31 obtained in the step (3) by utilizing an interference-free atmosphere of inert gas, and cooling to room temperature along with a furnace to obtain an isometric crystal structure with uniform and isotropic structure.
2. The heat treatment method for improving the mechanical property and the biological function stability of the magnesium alloy as claimed in claim, characterized in that: the surface of the magnesium alloy AZ31 is ground by water sand paper, including primary grinding and polishing; the primary grinding is carried out by using water sand paper with 400 meshes, and grinding is carried out for 1-3 minutes, so that an original oxide layer is eliminated; then immediately polishing, wherein the polishing is carried out by using water sand paper 1200-2400 meshes, and the surface finish of the magnesium alloy AZ31 is kept for 2-5 minutes.
3. The heat treatment method for improving the mechanical property and the biological function stability of the magnesium alloy according to claim 2, wherein: the primary grinding is carried out according to one direction, the oxide layer can be effectively removed according to the force requirement, and the primary grinding is carried out until the dark oxide layer is completely removed from the surface of the magnesium alloy AZ31, so that silver-white magnesium metal is generated; the grinding direction in the polishing process is vertical to the primary grinding direction, and the force is smaller than that of primary grinding until no obvious scratch is formed on the surface of the magnesium alloy AZ 31.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010140864.9A CN111534769A (en) | 2020-03-03 | 2020-03-03 | Heat treatment method for improving mechanical property and biological function stability of magnesium alloy |
| PCT/CN2021/000030 WO2021174998A1 (en) | 2020-03-03 | 2021-02-25 | Method for increasing mechanical performance and biological stability of magnesium alloy and for manufacturing material and applications |
| AU2021230640A AU2021230640B2 (en) | 2020-03-03 | 2021-02-25 | Methods for improving mechanical property and biological stability of magnesium alloy and for manufacturing material and applications |
| EP21764320.4A EP4108800A1 (en) | 2020-03-03 | 2021-02-25 | Method for increasing mechanical performance and biological stability of magnesium alloy and for manufacturing material and applications |
| JP2022552864A JP7507869B2 (en) | 2020-03-03 | 2021-02-25 | Method for improving mechanical properties and biological stability of magnesium alloys, and method for producing the material and its use |
| US17/905,456 US11938244B2 (en) | 2020-03-03 | 2021-02-25 | Methods for improving mechanical property and biological stability of magnesium alloy and manufacturing material and applications |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010140864.9A CN111534769A (en) | 2020-03-03 | 2020-03-03 | Heat treatment method for improving mechanical property and biological function stability of magnesium alloy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111534769A true CN111534769A (en) | 2020-08-14 |
Family
ID=71972854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010140864.9A Pending CN111534769A (en) | 2020-03-03 | 2020-03-03 | Heat treatment method for improving mechanical property and biological function stability of magnesium alloy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111534769A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021174998A1 (en) * | 2020-03-03 | 2021-09-10 | 李贺杰 | Method for increasing mechanical performance and biological stability of magnesium alloy and for manufacturing material and applications |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100768568B1 (en) * | 2006-06-05 | 2007-10-19 | 인하대학교 산학협력단 | Method of carrying out ecap at room temperature for magnesium materials |
| CN104302798A (en) * | 2012-06-26 | 2015-01-21 | 百多力股份公司 | Magnesium-zinc-calcium alloy, method for production thereof, and use thereof |
| WO2016170397A1 (en) * | 2015-04-23 | 2016-10-27 | Aperam | Steel, product made of said steel, and manufacturing method thereof |
| CN106715737A (en) * | 2014-09-09 | 2017-05-24 | 国立大学法人神户大学 | Device for fixing biological soft tissue, and method for producing same |
| CN108359919A (en) * | 2018-02-06 | 2018-08-03 | 常州大学 | A kind of mandatory method for oxidation preparing the pure magnesium of gradient structure and magnesium alloy |
| CN109868435A (en) * | 2019-04-15 | 2019-06-11 | 江苏沣沅医疗器械有限公司 | A kind of magnesium alloy pipe and its heat treatment method and application |
| CN110042327A (en) * | 2019-05-28 | 2019-07-23 | 北方民族大学 | A kind of a wide range of controllable Biological magnesium alloy of degradation rate |
-
2020
- 2020-03-03 CN CN202010140864.9A patent/CN111534769A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100768568B1 (en) * | 2006-06-05 | 2007-10-19 | 인하대학교 산학협력단 | Method of carrying out ecap at room temperature for magnesium materials |
| CN104302798A (en) * | 2012-06-26 | 2015-01-21 | 百多力股份公司 | Magnesium-zinc-calcium alloy, method for production thereof, and use thereof |
| CN106715737A (en) * | 2014-09-09 | 2017-05-24 | 国立大学法人神户大学 | Device for fixing biological soft tissue, and method for producing same |
| WO2016170397A1 (en) * | 2015-04-23 | 2016-10-27 | Aperam | Steel, product made of said steel, and manufacturing method thereof |
| CN108359919A (en) * | 2018-02-06 | 2018-08-03 | 常州大学 | A kind of mandatory method for oxidation preparing the pure magnesium of gradient structure and magnesium alloy |
| CN109868435A (en) * | 2019-04-15 | 2019-06-11 | 江苏沣沅医疗器械有限公司 | A kind of magnesium alloy pipe and its heat treatment method and application |
| CN110042327A (en) * | 2019-05-28 | 2019-07-23 | 北方民族大学 | A kind of a wide range of controllable Biological magnesium alloy of degradation rate |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021174998A1 (en) * | 2020-03-03 | 2021-09-10 | 李贺杰 | Method for increasing mechanical performance and biological stability of magnesium alloy and for manufacturing material and applications |
| US11938244B2 (en) | 2020-03-03 | 2024-03-26 | Hejie Li | Methods for improving mechanical property and biological stability of magnesium alloy and manufacturing material and applications |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Jamesh et al. | Electrochemical corrosion behavior of biodegradable Mg–Y–RE and Mg–Zn–Zr alloys in Ringer’s solution and simulated body fluid | |
| Zhang et al. | The effects of laser shock peening on the mechanical properties and biomedical behavior of AZ31B magnesium alloy | |
| Wen et al. | Improvement of the biomedical properties of titanium using SMAT and thermal oxidation | |
| Xie et al. | Nanocrystalline β-Ti alloy with high hardness, low Young's modulus and excellent in vitro biocompatibility for biomedical applications | |
| Huang et al. | In vitro degradation and biocompatibility of Fe–Pd and Fe–Pt composites fabricated by spark plasma sintering | |
| Li et al. | Evaluation of cyto-toxicity and corrosion behavior of alkali-heat-treated magnesium in simulated body fluid | |
| Uddin et al. | Synergistic effect of deep ball burnishing and HA coating on surface integrity, corrosion and immune response of biodegradable AZ31B Mg alloys | |
| Wang et al. | In vitro and in vivo studies on Ti-based bulk metallic glass as potential dental implant material | |
| Donato et al. | Cytotoxicity study of some Ti alloys used as biomaterial | |
| Sun et al. | Simultaneously improving surface mechanical properties and in vitro biocompatibility of pure titanium via surface mechanical attrition treatment combined with low-temperature plasma nitriding | |
| Kao et al. | Effects of duplex nitriding and TiN coating treatment on wear resistance, corrosion resistance and biocompatibility of Ti6Al4V alloy | |
| CN109487121A (en) | A kind of gear division titanium alloy and preparation method thereof | |
| Zhang et al. | Effects of laser shock peening on the corrosion behavior and biocompatibility of a nickel–titanium alloy | |
| Li et al. | Preparation of well-distributed titania nanopillar arrays on Ti6Al4V surface by induction heating for enhancing osteogenic differentiation of stem cells | |
| Aniołek et al. | Mechanical, tribological and adhesive properties of oxide layers obtained on the surface of the Ti–6Al–7Nb alloy in the thermal oxidation process | |
| Gonzalez et al. | Effects of Mg addition on the phase formation, morphology, and mechanical and tribological properties of Ti-Nb-Mg immiscible alloy coatings produced by magnetron co-sputtering | |
| CN111534769A (en) | Heat treatment method for improving mechanical property and biological function stability of magnesium alloy | |
| Trivedi et al. | Biocompatibility of ultrafine grained zircaloy-2 produced by cryorolling for medical applications | |
| Zhang et al. | Improved corrosion resistance of as-extruded GZ51K biomagnesium alloy with high mechanical properties by aging treatment | |
| Golasiński et al. | Evaluation of mechanical properties, in vitro corrosion resistance and biocompatibility of Gum Metal in the context of implant applications | |
| Sharkeev et al. | Microstructure, mechanical and biological properties of zirconium alloyed with niobium after severe plastic deformation | |
| CN111494704B (en) | Method for preparing magnesium-based alloy biomaterial with small peptide coating and application thereof | |
| CN115261772B (en) | Method for rapidly preparing ceramic modified layer on surface of zirconium alloy | |
| US11938244B2 (en) | Methods for improving mechanical property and biological stability of magnesium alloy and manufacturing material and applications | |
| JP2010138471A (en) | Surface treatment method for shape memory alloy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |