CN111534412B - 一种用于细胞磁珠标记的器件 - Google Patents
一种用于细胞磁珠标记的器件 Download PDFInfo
- Publication number
- CN111534412B CN111534412B CN202010454501.2A CN202010454501A CN111534412B CN 111534412 B CN111534412 B CN 111534412B CN 202010454501 A CN202010454501 A CN 202010454501A CN 111534412 B CN111534412 B CN 111534412B
- Authority
- CN
- China
- Prior art keywords
- inlet
- outlet
- mixed flow
- section
- mixer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000011324 bead Substances 0.000 title claims abstract description 47
- 238000002372 labelling Methods 0.000 title claims abstract description 26
- 239000011347 resin Substances 0.000 claims description 3
- 229920005989 resin Polymers 0.000 claims description 3
- 239000004677 Nylon Substances 0.000 claims description 2
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 claims description 2
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 claims description 2
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 claims description 2
- 229920001778 nylon Polymers 0.000 claims description 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 2
- 239000004626 polylactic acid Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 9
- 238000013461 design Methods 0.000 abstract description 4
- 230000010355 oscillation Effects 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 abstract description 3
- 210000004027 cell Anatomy 0.000 description 33
- 239000007788 liquid Substances 0.000 description 11
- 238000005516 engineering process Methods 0.000 description 8
- 238000012545 processing Methods 0.000 description 8
- 238000010146 3D printing Methods 0.000 description 7
- 239000012530 fluid Substances 0.000 description 7
- 230000009471 action Effects 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 108091023037 Aptamer Proteins 0.000 description 1
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 210000004925 microvascular endothelial cell Anatomy 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/06—Magnetic means
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Dispersion Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010454501.2A CN111534412B (zh) | 2020-05-26 | 2020-05-26 | 一种用于细胞磁珠标记的器件 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010454501.2A CN111534412B (zh) | 2020-05-26 | 2020-05-26 | 一种用于细胞磁珠标记的器件 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN111534412A CN111534412A (zh) | 2020-08-14 |
CN111534412B true CN111534412B (zh) | 2024-02-20 |
Family
ID=71978101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010454501.2A Active CN111534412B (zh) | 2020-05-26 | 2020-05-26 | 一种用于细胞磁珠标记的器件 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111534412B (zh) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006001196A1 (ja) * | 2004-06-24 | 2006-01-05 | The University Of Tokyo | 細胞分離装置、及び細胞分離方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11185830B2 (en) * | 2017-09-06 | 2021-11-30 | Waters Technologies Corporation | Fluid mixer |
-
2020
- 2020-05-26 CN CN202010454501.2A patent/CN111534412B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006001196A1 (ja) * | 2004-06-24 | 2006-01-05 | The University Of Tokyo | 細胞分離装置、及び細胞分離方法 |
Also Published As
Publication number | Publication date |
---|---|
CN111534412A (zh) | 2020-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US5971158A (en) | Absorption-enhanced differential extraction device | |
EP0730639B1 (en) | Cell separation device | |
CN101455949A (zh) | 用于使液体与试剂充分混合的微流控元件 | |
KR101636316B1 (ko) | 미세유체 분리장치, 이를 이용한 분리방법 및 이를 포함하는 혈액 내 순환희소세포 분리키트 | |
US7439075B2 (en) | Method and device for withdrawing suspended microparticles from a fluidic microsystem | |
CN103454126A (zh) | 一种可调式液滴发生装置 | |
CN107442017A (zh) | 具有优化流体混合的微混合器 | |
CN110124760B (zh) | 一种微流后置定量装置及微流控芯片 | |
CN110124758A (zh) | 微流控芯片的进样腔及单指标微流控芯片 | |
CN109304050A (zh) | 一种高效辅助萃取集成装置及方法 | |
CN111534412B (zh) | 一种用于细胞磁珠标记的器件 | |
CN113952993B (zh) | 集成微混合器与Tesla阀的多级惯性微流控血样处理芯片 | |
US11504681B2 (en) | Microfluidic mixing device and method | |
CN212476697U (zh) | 一种用于细胞磁珠标记的器件 | |
CN213398557U (zh) | 一种检测装置、血液分析仪 | |
CN210206901U (zh) | 一种用于乳化的双水相系统及其液滴生成模块 | |
CN110272811A (zh) | 一种基于双柱捕获的单细胞表面部分区域磁化装置及方法 | |
CN208599792U (zh) | 一种结构堆叠式微流控芯片夹具 | |
CN113462543B (zh) | 定量检测血液中癌细胞的微流控芯片 | |
CN214781742U (zh) | 一种微流控芯片盒 | |
CN113117769A (zh) | 一种在微流控芯片同一流道使用多种试剂的试剂切换阀 | |
CN115178199B (zh) | 无源微流控微反应器以及微流控芯片 | |
CN110272823A (zh) | 一种基于微通道阵列的多细胞表面部分区域磁化装置及方法 | |
US8790931B2 (en) | Method of collecting particles from a sample fluid by arranging the particles to settle and collect in a collecting portion of a collecting region | |
CN108445120A (zh) | 色谱仪用二元梯度溶剂输送系统 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB02 | Change of applicant information | ||
CB02 | Change of applicant information |
Country or region after: China Address after: 210042 rooms 601 and 605, 6 / F, building 5, Juhui Park, phase II, Xuzhuang high tech Zone, 108 Xuanwu Avenue, Xuanwu District, Nanjing, Jiangsu Province Applicant after: NANJING INTELLIGENT HIGH-END EQUIPMENT INDUSTRY RESEARCH INSTITUTE Co.,Ltd. Address before: Room 601, 6th Floor, Building 5, Juhuiyuan, Phase II, Xuzhuang High tech Zone, No. 108 Xuanwu Avenue, Xuanwu District, Nanjing City, Jiangsu Province, 210042 Applicant before: NANJING INTELLIGENT HIGH-END EQUIPMENT INDUSTRY RESEARCH INSTITUTE Co.,Ltd. Country or region before: China |
|
GR01 | Patent grant | ||
GR01 | Patent grant |