CN111528929B - Liver puncture biopsy device for preventing cancer cell planting - Google Patents

Liver puncture biopsy device for preventing cancer cell planting Download PDF

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Publication number
CN111528929B
CN111528929B CN202010377673.4A CN202010377673A CN111528929B CN 111528929 B CN111528929 B CN 111528929B CN 202010377673 A CN202010377673 A CN 202010377673A CN 111528929 B CN111528929 B CN 111528929B
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sheath
needle
tube
layer
heat
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CN111528929A (en
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王瑜
叶敏
张海燕
曾建挺
罗鲜樟
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Nuohetai Biotechnology Chongqing Co ltd
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Chongqing University Cancer Hospital
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/0233Pointed or sharp biopsy instruments
    • A61B10/0266Pointed or sharp biopsy instruments means for severing sample
    • A61B10/0275Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • A61B10/0233Pointed or sharp biopsy instruments
    • A61B10/0283Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B2010/009Various features of diagnostic instruments

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

The invention discloses a liver puncture biopsy device for preventing cancer cells from being planted, which comprises a biopsy needle and a needle sheath, wherein the needle sheath is sleeved outside the biopsy needle, and the front end of the needle sheath and the front end of the biopsy needle are combined to form a puncture head; the needle sheath includes sheath pipe and tube socket, and the rear end of needle sheath sets up on the tube socket, wherein: the sheath tube comprises a first heat conduction layer, an electric heating layer and a second heat conduction layer which are sequentially arranged from inside to outside in the radial direction, and the electric heating layer is used for generating heat and conducting the heat to the first heat conduction layer and the second heat conduction layer; the tube seat is perforated with a pinhole and comprises a heating control module which is used for controlling the working state of the electric heating layer. After the biopsy needle punctures the cancer tissue and finishes sampling, the sheath tube is heated to maintain the temperature at 40-60 ℃, the cancer cells attached to the sheath tube can be inactivated and killed within about 10 minutes, and the biopsy needle and the sheath are drawn out at the time, so that the cancer cells can be prevented from being planted in other tissues, and the cancer cell metastasis is avoided.

Description

Liver puncture biopsy device for preventing cancer cell planting
Technical Field
The invention relates to the field of medical instruments, in particular to a liver puncture biopsy device for preventing cancer cells from being planted.
Background
A liver puncture biopsy needle, which is called liver biopsy needle for short, is a medical instrument used for extracting and inspecting liver lesion tissue samples. In the biopsy operation, the liver is punctured percutaneously under the guidance of CT or B-ultrasound, or directly under the surveillance of a laparoscope, and a lesion tissue of the liver is extracted by negative pressure for examination. It should be noted that if the lesion tissue is cancer tissue, the surface of the liver biopsy needle after puncturing the cancer tissue will carry cancer cells, and then the liver biopsy needle will be drawn out through the abdominal cavity and the skin, which may cause metastasis of cancer cells, and the cancer cells will be planted on other tissues.
Disclosure of Invention
The invention provides a liver puncture biopsy device which can prevent cancer cells from being planted in other tissues and avoid cancer cell metastasis.
The invention provides a liver puncture biopsy device for preventing cancer cell planting, which comprises a biopsy needle and a needle sheath, wherein the needle sheath is sheathed on the biopsy needle, and the front end of the needle sheath and the front end of the biopsy needle are combined to form a puncture head; the needle sheath includes sheath pipe and tube socket, the rear end of needle sheath sets up on the tube socket, wherein:
the sheath tube comprises a first heat conduction layer, an electric heating layer and a second heat conduction layer which are sequentially arranged from inside to outside in the radial direction, and the electric heating layer is used for generating heat and conducting the heat to the first heat conduction layer and the second heat conduction layer;
the tube seat is provided with a through pin hole in a penetrating mode and comprises a heating control module, and the heating control module is used for controlling the working state of the electric heating layer.
Optionally, the electric heating layer includes a forward spiral electric heating wire and a reverse spiral electric heating wire that are connected, and the forward spiral electric heating wire and the reverse spiral electric heating wire are combined to form a grid-shaped cylindrical structure.
Furthermore, a positive power supply hole and a negative power supply hole are formed in the rear end of the sheath tube, the positive power supply hole is connected with the positive spiral electric heating wire, and the negative power supply hole is connected with the reverse spiral electric heating wire; the tube seat further comprises a positive pin and a negative pin extending out of the front end, the positive pin is placed in the positive power hole, and the negative pin is placed in the negative power hole.
Optionally, a heat induction hole is formed at the rear end of the sheath tube, and the heat induction hole is connected to the first heat conduction layer and/or the second heat conduction layer; the tube holder further comprises a probe extending from the front end, the probe being inserted into the heat sensing hole; the heating control module comprises a temperature sensor, and the temperature sensor is connected with the probe; the heating control module is also used for adjusting the output power of the electric heating layer so as to keep the temperature of the first heat conduction layer and/or the second heat conduction layer at a preset temperature value.
Furthermore, the tube socket further comprises a shell and a middle through rear cover, the middle through rear cover is installed at the rear end of the shell, and the heating control module is arranged in the shell.
Furthermore, the tube base also comprises a display screen arranged on the shell; the display screen is connected with the heating control module and used for displaying the real-time temperature of the first heat conduction layer and/or the second heat conduction layer.
Optionally, the tube seat further includes a non-magnetic inner tube and a collar, an inner wall of the non-magnetic inner tube forms a part of the needle passing hole, and the collar is sleeved on an outer wall of the non-magnetic inner tube and can slide in the axial direction; the outer wall of the lantern ring is fixedly sleeved with a magnetic ring, and the magnetic ring is used for moving along the axial direction of the biopsy needle through magnetic force; the outer wall of the nonmagnetic inner tube is provided with a first contact connected with the heating control module, the lantern ring is relatively provided with a second contact, and when the first contact is separated from the second contact, the heating control module controls the electric heating layer to generate heat.
Furthermore, an axial sliding groove is formed in the outer wall of the nonmagnetic inner tube, and a convex rib matched with the axial sliding groove is formed in the inner wall of the lantern ring.
Therefore, the liver puncture biopsy device comprises a biopsy needle and a needle sheath sleeved outside the biopsy needle, wherein the needle sheath comprises a sheath tube and a tube seat, a heating control module is arranged in the tube seat, an electric heating layer is arranged in the sheath tube, and after the biopsy needle punctures cancer tissues and finishes sampling, the heating control module controls the electric heating layer to generate heat, so that the temperature of the outer wall of the sheath tube is maintained at 40-60 ℃, cancer cells attached to the sheath tube can be inactivated and killed within about 10 minutes, and the biopsy needle and the needle sheath are pulled out together at the moment, so that the cancer cells can be prevented from being planted in other tissues, and the cancer cell transfer is avoided.
The advantageous effects of the additional features of the present invention will be explained in the detailed description section of the present specification.
Drawings
In order to illustrate the embodiments of the invention more clearly, the drawings that are needed for describing the embodiments or prior art will be briefly described below, it being apparent that the drawings in the following description are only some embodiments of the invention, and that other drawings may be obtained by those skilled in the art without inventive effort.
FIG. 1 is a schematic structural diagram of a biopsy device for liver puncture provided by an embodiment of the present invention;
FIG. 2 is a partial enlarged view of a sheath A according to an embodiment of the present invention;
FIG. 3 is a schematic structural diagram of an electrothermal layer according to an embodiment of the present invention;
FIG. 4 is an exploded view of a needle sheath according to an embodiment of the present invention;
FIG. 5 is an electrical schematic diagram of a biopsy device for liver biopsy according to an embodiment of the present invention;
FIG. 6 is a schematic process diagram of a biopsy provided by an embodiment of the present invention;
fig. 7 is a schematic process diagram of another biopsy provided by the embodiment of the present invention.
Reference numerals:
biopsy needle-100, needle sheath-200;
sheath-210, first heat conduction layer-211, electric heating layer-212, second heat conduction layer-213, positive spiral electric heating wire-214,
a reverse spiral heating wire-215, a positive power supply hole-216, a negative power supply hole-217 and a thermal induction hole-218;
a tube seat-220, a positive pin-221, a negative pin-222, a probe-223, a shell-224, a middle through back cover-225,
a display screen-226, a non-magnetic inner tube-227, a loop-228, a magnetic ring-229, a pinhole-230, a first contact-231,
a second contact-232, an axial sliding groove-233 and a convex rib-234;
a heating control module-240, a temperature sensor-241, a microprocessor-242, an output circuit-243 and a timer-244.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the embodiment of the present invention, the directional word "front" refers to a direction close to the patient during the operation, and correspondingly, the directional word "rear" refers to a direction away from the patient during the operation.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a liver biopsy device according to an embodiment of the present invention, which includes a biopsy needle 100 and a needle sheath 200, wherein the needle sheath 200 is externally sleeved on the biopsy needle 100.
The front end of the needle sheath 200 forms a puncture head in combination with the front end of the biopsy needle 100, i.e. when the biopsy needle 100 is pushed forward to the end, the outer edge of the front end of the needle sheath 200 is smoothly connected with the outer edge of the front end of the biopsy needle 100 in a transition manner, and the puncture head is formed from thick to thin, and the shape of the puncture head may be conical as shown in fig. 1.
Further, the needle sheath 200 comprises a sheath tube 210 and a hub 220, the rear end of the needle sheath 200 is arranged on the hub 220, wherein:
the sheath 210 includes a first heat conducting layer 211, an electric heating layer 212 and a second heat conducting layer 213, which are sequentially arranged from inside to outside in the radial direction, as shown in fig. 2, the electric heating layer 212 generates heat after being electrified, and the heat is conducted to the adjacent first heat conducting layer 211 and the second heat conducting layer 213. Optionally, the materials of the first heat conduction layer 211 and the second heat conduction layer 213 are selected from aluminum alloys with good heat conductivity. Still alternatively, the first heat conducting layer 211 and the second heat conducting layer 213 are the outermost layers of the sheath 210, and directly contact human tissue.
The tube holder 220 is perforated with a needle hole 230, and the needle hole 230 is aligned and communicated with the sheath tube 210. The socket 220 includes a heating control module 240, and the heating control module 240 is used to control the operation state of the electrothermal layer 212, specifically including whether or not to be powered and the power to be powered.
In a specific implementation, first, the biopsy needle 100 and the needle sheath 200 penetrate the liver through the skin, or directly penetrate the liver under the monitoring of a laparoscope, and reach a target position (near the biopsy tissue), as shown in fig. 6; then, the biopsy needle 100 is retracted backward to extract a part of the biopsy tissue into the needle sheath 200, as shown in fig. 7, the heating control module 240 controls the electrothermal layer 212 to generate heat so that the temperature of the outer wall of the sheath 210 is maintained at 40 to 60 ℃, if the biopsy tissue is cancer tissue, the cancer cells attached to the sheath 210 are inactivated and killed within about 10 minutes, and at this time, the biopsy needle 100 and the needle sheath 200 are extracted together, so that the cancer cells can be prevented from being planted in other tissues, and the cancer cells can be prevented from being transferred.
Optionally, referring to fig. 3, the electric heating layer 212 includes a forward spiral heating wire 214 and a reverse spiral heating wire 215, one end of each of which is connected, that is, the forward spiral heating wire 214 and the reverse spiral heating wire 215 are connected in series after being powered on, and the forward spiral heating wire 214 and the reverse spiral heating wire 215 are combined to form a grid-shaped cylindrical structure. It should be appreciated that the spiral, grid, and cylindrical combination structure facilitates uniform heat dissipation, such that the sheath 210 generates heat uniformly.
Correspondingly, referring to fig. 4, the sheath 210 is provided at the rear end thereof with a positive power hole 216 and a negative power hole 217, the positive power hole 216 is connected to the positive spiral heating wire 214, and the negative power hole 217 is connected to the reverse spiral heating wire 215; the socket 220 further includes a positive pin 221 and a negative pin 222 extending from the front end, the positive pin 221 being received in the positive power hole 216 and the negative pin 222 being received in the negative power hole 217. That is, the flow of current after energization is: the positive pin 221 → the positive power hole 216 → the positive spiral heating wire 214 → the reverse spiral heating wire 215 → the negative power hole 217 → the negative pin 222.
Optionally, referring to fig. 4, the back end of the sheath 210 is provided with a thermal sensing hole 218, and the thermal sensing hole 218 is connected to the first heat conduction layer 211 and/or the second heat conduction layer 213, that is, the thermal sensing hole 218 may be formed in the first heat conduction layer 211, or formed in the second heat conduction layer 213, or formed in the first heat conduction layer 211 and the second heat conduction layer 213, so that the temperature of the sheath 210 can be measured more accurately by directly forming the thermal conduction layers. The header 220 also includes a probe 223 extending from the front end, the probe 223 being disposed in the heat sensing aperture 218; the heating control module 240 includes a temperature sensor 241, the temperature sensor 241 being connected to the probe 223; the heating control module 240 is further configured to adjust output power to the electric heating layer 212, so as to maintain the temperature of the first heat conduction layer 211 and/or the second heat conduction layer 213 at a preset temperature value, in this embodiment, a value range of the preset temperature value is 40 to 60 ℃.
Specifically, referring to fig. 5, the heating control module 240 at least includes a temperature sensor 241, a microprocessor 242, an output circuit 243 and a timer 244, wherein the temperature sensor 241 measures the temperature of the sheath 210 through the probe 223, and adjusts the output power of the output circuit 243 according to the measured temperature, so as to maintain the temperature of the sheath 210 at a preset temperature value, and after the timer 244 records a preset time, the output circuit 243 is controlled to stop outputting, so as to avoid excessive damage to human tissues under the condition of ensuring that the inactivated and attached cancer cells can be killed.
Optionally, referring to fig. 4, the socket 220 further includes a housing 224 and a middle through rear cover 225, the middle through rear cover 225 is installed at the rear end of the housing 224, and the heating control module 240 is disposed in the housing 224 instead of the through-hole 230. The housing 224 is cylindrical, a middle through portion of the middle through rear cover 225 serves as a part of the needle passing hole 230, the middle through rear cover 225 is formed with a step-shaped small diameter section and a step-shaped large diameter section, the small diameter section is used for being tightly matched with the inner wall of the housing 224, and the large diameter section is used for abutting against the rear end of the housing 224.
Optionally, referring to fig. 4, the tube socket 220 further includes a display 226 disposed on the housing, the display 226 is connected to the heating control module 240, specifically, connected to the microprocessor 242 as shown in fig. 5, and is configured to display the real-time temperature of the first heat conducting layer 211 and/or the second heat conducting layer 213, that is, the real-time temperature of the tube sheath, and of course, may also display the heating time, or send out a prompt, an abnormal alarm, and the like.
Optionally, referring to fig. 4, the tube holder 220 further includes a non-magnetic inner tube 227 and a collar 228, an inner wall of the non-magnetic inner tube 227 forms a part of the through-hole 230, the collar 228 is sleeved on an outer wall of the non-magnetic inner tube 227 and can slide along an axial direction, wherein the non-magnetic inner tube 227 is a non-magnetic body, and corresponds to a magnetic body, and is mainly characterized by having no magnetic property per se and being incapable of being magnetized, such as plastic. The outer wall of the collar 228 is fixedly sleeved with a magnetic ring 229, and since the nonmagnetic inner tube 227 is a nonmagnetic body and the biopsy needle 100 is a generally metallic magnet, the magnetic ring 229 can follow the biopsy needle 100 to move axially by magnetic force. The outer wall of the non-magnetic inner tube 227 is provided with a first contact 231 connected with the heating control module 240, and particularly connected with the microprocessor 242 as shown in fig. 5, and the collar 228 is provided with a second contact 232 opposite to the first contact 231, so that the heating control module 240 controls the electrothermal layer 212 to generate heat when the first contact 231 is separated from the second contact 232.
In specific implementation, when the biopsy needle 100 is pushed forward to the end, the puncture is performed at this time, the biopsy needle 100 is retracted backward, the biopsy needle 100 is used to extract a portion of biopsy tissue at this time, during the process of retracting the biopsy needle 100 backward, the magnetic ring 229 moves backward along with the biopsy needle 100 due to magnetic force, so that the first contact 231 on the collar 228 is separated from the second contact 232 in the housing 224, and at this time, the microprocessor 242 senses the interruption of the current signal (current passes only when the first contact 231 is in contact with the second contact 232), and further controls the output circuit 243 to output the external power, so that the electrothermal layer 212 generates heat, the heating function is realized, and cancer cells attached to the sheath 210 are inactivated and killed. This embodiment can realize can automatically opening the heating function after taking out the biopsy tissue, avoids medical staff to participate in the manual switch operation, has promoted operation experience, and the operation links up, and the cooperation is compact, has improved operation efficiency. In addition, the design also avoids using a physical key switch, thereby avoiding the problem that the internal circuit is damaged due to poor tightness of the physical key switch when the surgical instrument is disinfected at high temperature and high pressure after operation.
Further, referring to fig. 4, an axial sliding slot 233 is formed on an outer wall of the nonmagnetic inner tube 227, and a rib 234 engaged with the axial sliding slot 233 is formed on an inner wall of the collar 228, so that the collar 228 can only axially move relative to the nonmagnetic inner tube 227 but cannot circumferentially rotate, a motion track is defined, and alignment contact between the first contact 231 and the second contact 232 is facilitated. Alternatively, as shown in fig. 4, two axial sliding grooves 233 and two ribs 234 are provided, forming two sets, and are provided on two sides.
While the invention has been described in connection with what is presently considered to be the most practical and preferred embodiment, it is to be understood that the invention is not to be limited to the disclosed embodiment, but on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.

Claims (7)

1. A liver puncture biopsy device for preventing cancer cell planting is characterized by comprising a biopsy needle and a needle sheath, wherein the needle sheath is sleeved on the biopsy needle, and the front end of the needle sheath and the front end of the biopsy needle are combined to form a puncture head; the needle sheath includes sheath pipe and tube socket, the rear end of needle sheath sets up on the tube socket, wherein:
the sheath tube comprises a first heat conduction layer, an electric heating layer and a second heat conduction layer which are sequentially arranged from inside to outside in the radial direction, and the electric heating layer is used for generating heat and conducting the heat to the first heat conduction layer and the second heat conduction layer;
the tube seat is provided with a pinhole in a penetrating way and comprises a heating control module which is used for controlling the working state of the electric heating layer;
the tube seat also comprises a non-magnetic inner tube and a lantern ring, wherein the inner wall of the non-magnetic inner tube forms a part of the needle passing hole, and the lantern ring is sleeved on the outer wall of the non-magnetic inner tube and can slide along the axial direction; the outer wall of the lantern ring is fixedly sleeved with a magnetic ring, and the magnetic ring is used for moving along the axial direction of the biopsy needle through magnetic force; the outer wall of the nonmagnetic inner tube is provided with a first contact connected with the heating control module, the lantern ring is relatively provided with a second contact, and when the first contact is separated from the second contact, the heating control module controls the electric heating layer to generate heat.
2. The liver biopsy apparatus of claim 1, wherein the electrically heated layer comprises a forward spiral heating wire and a reverse spiral heating wire connected together to form a grid-like cylindrical structure.
3. The liver biopsy apparatus of claim 2, wherein the sheath defines a positive power hole and a negative power hole at a rear end thereof, the positive power hole is connected to the positive spiral heating wire, and the negative power hole is connected to the reverse spiral heating wire; the tube seat further comprises a positive pin and a negative pin extending out of the front end, the positive pin is placed in the positive power hole, and the negative pin is placed in the negative power hole.
4. The liver biopsy apparatus of claim 1, wherein the sheath has a heat-sensing hole at the rear end, and the heat-sensing hole is connected to the first heat-conducting layer and/or the second heat-conducting layer; the tube holder further comprises a probe extending from the front end, the probe being inserted into the heat sensing hole; the heating control module comprises a temperature sensor, and the temperature sensor is connected with the probe; the heating control module is also used for adjusting the output power of the electric heating layer so as to keep the temperature of the first heat conduction layer and/or the second heat conduction layer at a preset temperature value.
5. The liver biopsy apparatus of claim 4, wherein the hub further comprises a housing and a hollow rear cover mounted to a rear end of the housing, the heating control module being disposed within the housing.
6. The liver biopsy apparatus of claim 5, wherein the hub further comprises a display screen disposed on the housing; the display screen is connected with the heating control module and used for displaying the real-time temperature of the first heat conduction layer and/or the second heat conduction layer.
7. The liver biopsy apparatus of claim 1, wherein the outer wall of the inner non-magnetic tube has axial sliding grooves formed thereon, and the inner wall of the collar has ribs formed thereon for engaging the axial sliding grooves.
CN202010377673.4A 2020-05-07 2020-05-07 Liver puncture biopsy device for preventing cancer cell planting Active CN111528929B (en)

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CN111528929B true CN111528929B (en) 2023-03-28

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GB0620063D0 (en) * 2006-10-10 2006-11-22 Medical Device Innovations Ltd Needle structure and method of performing needle biopsies
CN201524123U (en) * 2009-11-02 2010-07-14 胡小良 Puncture cannula for laparoscopic surgery by means of vagina water injection
CN104367349A (en) * 2014-11-21 2015-02-25 曾惠清 Automatic radiofrequency ablation negative pressure biopsy system
CN204909511U (en) * 2015-08-24 2015-12-30 上海市浦东医院 Take novel thyroid gland pjncture needle of scale nook closing member and protection sheath
CN106236702A (en) * 2016-02-18 2016-12-21 王胜军 Eliminate postoperative cancer recurrence and the liquid medicine of transfer and application process
US10959776B2 (en) * 2016-11-30 2021-03-30 Traceless Biopsy, Llc Biopsy tract ablation system for tumor seeding prevention and cauterization
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CN109646059A (en) * 2019-01-03 2019-04-19 周海丰 The full-automatic biopsy puncture device of mammary gland

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