CN111514473A - Radiotherapy method for cancer cells - Google Patents
Radiotherapy method for cancer cells Download PDFInfo
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- CN111514473A CN111514473A CN202010196882.9A CN202010196882A CN111514473A CN 111514473 A CN111514473 A CN 111514473A CN 202010196882 A CN202010196882 A CN 202010196882A CN 111514473 A CN111514473 A CN 111514473A
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- cancer cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1007—Arrangements or means for the introduction of sources into the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
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Abstract
The invention discloses a radiotherapy method for cancer cells, which comprises the steps of radioactive particle preparation, cleaning, coupling, isotope labeling, particle injection into a patient body and gamma ray treatment. The invention has the beneficial effects that: the high molecular degradable material with better biocompatibility is adopted as the particle base material, is easy to decompose when being injected into a human body, is eliminated along with metabolism of a human body, reduces damage to the body of a patient, ensures the structural stability of the base material in the subsequent operation process, carries out grafting cleaning and coupling reaction on the prepared base material, removes free functional groups on the surface of the base material, and is convenient for the radioactive isotope to carry out replacement reaction on the base material, thereby ensuring that cancer cells can be accurately positioned after the base material is injected into the human body, facilitating the centralized cleaning of gamma rays, improving the safety of the treatment method, reducing the possibility of killing safe and normal cells, improving the operation safety of the method, and reducing the residual quantity of the cancer cells in the body of the patient to a certain extent.
Description
Technical Field
The invention relates to a treatment method, in particular to a radiation treatment method for cancer cells, and belongs to the technical field of cancer cell treatment.
Background
Tumor radiotherapy is a local treatment for tumors using radiation. The radioactive rays include alpha, beta and gamma rays generated by radioactive isotopes and x rays, electron beams, proton beams and other particle beams generated by various x-ray therapeutic machines or accelerators, about 70 percent of cancer patients need radiotherapy in the process of treating cancer, and about 40 percent of cancers can be radically treated by radiotherapy. The role and position of radiotherapy in tumor treatment are increasingly prominent, and the radiotherapy has become one of the main means for treating malignant tumors.
Although radiotherapy has been used for decades, it has been developed rapidly, and with the help of the development of CT imaging technology and computer technology, the current radiotherapy technology has been developed from two-dimensional radiotherapy to three-dimensional radiotherapy and four-dimensional radiotherapy, and the radiotherapy dose distribution has also been developed from point dose to volume dose distribution and dose intensity modulation in volume dose distribution.
However, although the existing treatment method is effective, the existing treatment method can kill normal cells sometimes, the accuracy is not high enough, the success rate of radical treatment by radiotherapy has a space for improving, the existing treatment method needs to be more finely processed in the aspect of anti-cancer drug dosage distribution, and some particles in the existing treatment method have harm to human bodies.
Disclosure of Invention
The present invention has been made to solve the above problems, and an object of the present invention is to provide a radiotherapy method for cancer cells.
The invention realizes the purpose through the following technical scheme: a method of radiotherapy for cancer cells comprising the steps of:
preparing radioactive particles, namely preparing a high-molecular degradable material with good biocompatibility as a base material;
step two, cleaning, namely soaking and cleaning the prepared radioactive particles by using a modified solution with the concentration of 0.1-0.3 mol/L;
step three, coupling, namely soaking the cleaned particles in a coupling agent for 2 hours;
step four, isotope labeling, namely adding a solution containing iodine element into the solution in the step three to perform isotope labeling on the radioactive particles;
injecting the particles into the body of the patient, injecting the obtained radioactive particles into the body of the patient, and carrying out element radiation;
step six, gamma ray treatment, namely using a machine to emit gamma rays to kill cancer cells marked by isotopes.
As a still further scheme of the invention: in the first step, the high molecular degradable material with good biocompatibility is a mixed copolymer of polylactic acid and polyurethane.
As a still further scheme of the invention: in the second step, the surface modification solution is chitosan-acetic acid solution, wherein the chitosan is firstly uniformly mixed with ethanol water solution, sealed to ensure that the chitosan is fully expanded, then diluted acetic acid solution is added, uniformly stirred and kept stand for a period of time.
As a still further scheme of the invention: in the third step, the coupling agent solution is glutaraldehyde aqueous solution, and after the coupling reaction is finished, solution containing iodine element is added to remove free functional groups.
As a still further scheme of the invention: in the fourth step, the iodine element in the particles obtained in the third step is replaced by radioactive isotope.
The invention has the beneficial effects that: the radiation therapy method for cancer cells is reasonably designed:
1. the high molecular degradable material with better biocompatibility is adopted as the particle base material, is easy to decompose when injected into a human body, is eliminated along with the metabolism of the human body, reduces the damage to the body of a patient, and ensures the structural stability of the base material in the subsequent operation process;
2. the prepared base material is subjected to grafting cleaning and coupling reaction, free functional groups on the surface of the base material are removed, and the base material is convenient to be subjected to replacement reaction by radioactive isotopes, so that the cancer cells can be accurately positioned after the radioactive isotopes are injected into a human body, the gamma rays are convenient to be intensively cleaned, the safety of the treatment method is improved, the possibility of killing safe and normal cells by the radioactive isotopes is reduced, the operation safety of the method is improved, and the residual quantity of the cancer cells in the body of a patient is reduced to a certain extent.
Drawings
FIG. 1 is a schematic view of the flow structure of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1, a method of radiation therapy for cancer cells includes the steps of:
preparing radioactive particles, namely preparing a high-molecular degradable material with good biocompatibility as a base material;
step two, cleaning, namely soaking and cleaning the prepared radioactive particles by using a modified solution with the concentration of 0.1-0.3 mol/L;
step three, coupling, namely soaking the cleaned particles in a coupling agent for 2 hours;
step four, isotope labeling, namely adding a solution containing iodine element into the solution in the step three to perform isotope labeling on the radioactive particles;
injecting the particles into the body of the patient, injecting the obtained radioactive particles into the body of the patient, and carrying out element radiation;
step six, gamma ray treatment, namely using a machine to emit gamma rays to kill cancer cells marked by isotopes.
Further, in the first step of the present invention, the high molecular degradable material with good biocompatibility is a mixed copolymer of polylactic acid and polyurethane, and the high molecular degradable material with good biocompatibility is used as a particle substrate, so that the particle substrate is easily decomposed when injected into a human body, the damage to the body of a patient is reduced along with the elimination of metabolism of a human, and the structural stability of the substrate in the subsequent operation process is ensured.
Further, in the second step of the present invention, the surface modification solution is a chitosan-acetic acid solution, wherein the chitosan is first uniformly mixed with the ethanol aqueous solution, and then sealed to fully expand the chitosan, and then the diluted acetic acid solution is added to be uniformly stirred, and then the mixture is left for a period of time to ensure the purity of the prepared base material, and to facilitate the subsequent replacement between isotopes.
Further, in the third step of the present invention, the coupling agent solution is a glutaraldehyde aqueous solution, and after the coupling reaction is completed, a solution containing iodine is added to remove free functional groups, so as to further remove impurities on the surface of the substrate, and improve the accuracy of the treatment method.
Furthermore, in the fourth step of the present invention, the radioactive isotope is used to replace iodine in the particles obtained in the third step, which facilitates the centralized cleaning of gamma rays, improves the safety of the treatment method, reduces the possibility of killing safe normal cells, improves the operation safety of the method, and reduces the residual amount of cancer cells in the patient to a certain extent.
The working principle is as follows: when the radiotherapy method for cancer cells is used, firstly, a base material of radioactive particles is prepared, then, the base material is soaked and cleaned for 1 to 2 hours by using a modified solution with the concentration of 0.1 to 0.3mol/L, the cleaned particles are put into a coupling agent solution to be continuously soaked for two hours, after the soaking is finished, a solution containing iodine elements is added into the solution in the step three to carry out isotope labeling on the radioactive particles, the obtained base material particles are replaced by the particles with the radioactive elements, then, the particles are injected into a human body to be automatically decomposed, cancer cells are searched, and the radiation sterilization is carried out.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (5)
1. A method of radiotherapy for cancer cells, characterized by: the method comprises the following steps:
preparing radioactive particles, namely preparing a high-molecular degradable material with good biocompatibility as a base material;
step two, cleaning, namely soaking and cleaning the prepared radioactive particles by using a modified solution with the concentration of 0.1-0.3 mol/L;
step three, coupling, namely soaking the cleaned particles in a coupling agent for 2 hours;
step four, isotope labeling, namely adding a solution containing iodine element into the solution in the step three to perform isotope labeling on the radioactive particles;
injecting the particles into the body of the patient, injecting the obtained radioactive particles into the body of the patient, and carrying out element radiation;
step six, gamma ray treatment, namely using a machine to emit gamma rays to kill cancer cells marked by isotopes.
2. A method of radiotherapy for cancer cells according to claim 1, characterized in that: in the first step, the high molecular degradable material with good biocompatibility is a mixed copolymer of polylactic acid and polyurethane.
3. A method of radiotherapy for cancer cells according to claim 1, characterized in that: in the second step, the surface modification solution is chitosan-acetic acid solution, wherein the chitosan is firstly uniformly mixed with ethanol water solution, sealed to ensure that the chitosan is fully expanded, then diluted acetic acid solution is added, uniformly stirred and kept stand for a period of time.
4. A method of radiotherapy for cancer cells according to claim 1, characterized in that: in the third step, the coupling agent solution is glutaraldehyde aqueous solution, and after the coupling reaction is finished, solution containing iodine element is added to remove free functional groups.
5. A method of radiotherapy for cancer cells according to claim 1, characterized in that: in the fourth step, the iodine element in the particles obtained in the third step is replaced by radioactive isotope.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010196882.9A CN111514473A (en) | 2020-03-19 | 2020-03-19 | Radiotherapy method for cancer cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010196882.9A CN111514473A (en) | 2020-03-19 | 2020-03-19 | Radiotherapy method for cancer cells |
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| Publication Number | Publication Date |
|---|---|
| CN111514473A true CN111514473A (en) | 2020-08-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010196882.9A Pending CN111514473A (en) | 2020-03-19 | 2020-03-19 | Radiotherapy method for cancer cells |
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|---|---|
| CN (1) | CN111514473A (en) |
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2020
- 2020-03-19 CN CN202010196882.9A patent/CN111514473A/en active Pending
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Application publication date: 20200811 |