CN111513773B - Recoverable ventricular isolation device, recovery device and system - Google Patents
Recoverable ventricular isolation device, recovery device and system Download PDFInfo
- Publication number
- CN111513773B CN111513773B CN202010236676.6A CN202010236676A CN111513773B CN 111513773 B CN111513773 B CN 111513773B CN 202010236676 A CN202010236676 A CN 202010236676A CN 111513773 B CN111513773 B CN 111513773B
- Authority
- CN
- China
- Prior art keywords
- recovery
- ventricular
- isolating
- joint
- ventricular isolation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
- A61B2017/00238—Type of minimally invasive operation
- A61B2017/00243—Type of minimally invasive operation cardiac
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
- A61B2017/00632—Occluding a cavity, i.e. closing a blind opening
Abstract
The invention provides a recoverable ventricular isolation device, a recovery device and a system, wherein the ventricular isolation device comprises: a first device body and a spacer for isolating a ventricle; the first device body is provided with a containing cavity for containing the isolating piece; the containing cavity is internally provided with a push head, and the push head is connected with a push rod; an ejection outlet is formed in one end, opposite to the pushing head, of the containing cavity; the isolating piece comprises a recovery joint used for recovering the isolating piece, and a clamping groove is formed in the recovery joint. Through set up the draw-in groove on retrieving the joint, be convenient for retrieve the separator, avoided the risk that needs carry out the open chest operation.
Description
Technical Field
The invention relates to the technical field of ventricular therapeutic equipment, in particular to a recyclable ventricular isolation device, a recyclable ventricular isolation system and a recyclable ventricular isolation system recycling device and a recyclable ventricular isolation system recycling system.
Background
Heart failure, collectively referred to as heart failure, is characterized by abnormal cardiac structure or function, which in turn causes impairment of ventricular filling or ejection capacity, with a high mortality rate. Clinically, the typical heart failure case is that after acute anterior wall myocardial infarction, myocardial necrosis and postcicatrization occur, which leads to left ventricle reconstruction, left ventricle enlargement and ventricular contraction function reduction.
The heart failure symptom can be relieved through Percutaneous Ventricular Reconstruction (PVR), the operation principle is that a ventricular isolation device is implanted into the ventricle of a patient through a minimally invasive intervention method, and after the device is implanted, the volume of the left ventricle can be reduced, the tension of the ventricle wall is relieved, and the purpose of improving ventricular remodeling is achieved.
In the prior art, a common ventricular isolation device is the PARACHUTE left ventricular isolation device from cadioka nedyx, usa. However, since the device is implanted into the human body, it is not recyclable, and if it is necessary to take out the device due to a disease, an open chest operation must be performed, which has a great risk, is very easy to cause a wound to the human body, and even dies.
Therefore, the prior art has defects and needs to be improved and developed.
Disclosure of Invention
The present invention is directed to provide a recyclable ventricular isolation device, a recyclable ventricular isolation device and a recyclable ventricular isolation system, which are designed to solve the problem that the ventricular isolation device in the prior art is not recyclable.
The technical scheme adopted by the invention for solving the technical problem is as follows:
a retrievable ventricular isolation device, comprising:
a first device body and a spacer for isolating a ventricle; the first device body is provided with a containing cavity for containing the isolating piece; the containing cavity is internally provided with a push head, and the push head is connected with a push rod; an ejection outlet is formed in one end, opposite to the pushing head, of the containing cavity; the isolating piece comprises a recovery joint used for recovering the isolating piece, and a clamping groove is formed in the recovery joint.
Furthermore, one end of the recovery joint is provided with a plurality of supporting bones, and the plane area formed by one end of the supporting bones far away from the recovery joint is larger than the cross section of the recovery joint.
Further, the supporting bone is made of nickel titanium memory alloy and is umbrella-shaped.
Furthermore, the supporting ribs are covered with a coating layer as an umbrella surface of the supporting ribs, and the coating layer is made of polytetrafluoroethylene.
Furthermore, one end of the support bone, which is far away from the recovery joint, is provided with a fixing anchor, and the fixing anchors on the support bones are arranged on the opposite inner sides of the support bones.
The present disclosure also provides a recycling apparatus for recycling the above-described separator, wherein the recycling apparatus comprises:
a hollow second device body and a recovery member; the second device body is internally provided with a pull rod and a recovery piece connected with the pull rod, and the recovery piece is clamped with the clamping groove.
Furthermore, the clamping groove is formed in the side face of the recycling connector, and the recycling part is annular.
Furthermore, the draw-in groove is seted up retrieve to connect and deviates from support the terminal surface of bone, be used for with at least one barb has been set up on the recovery piece that the draw-in groove held mutually.
Furthermore, an isolation magnetic absorption layer is coated on the inner side of the clamping groove, a recovery magnetic absorption layer is coated on the outer side of the recovery piece, and the recovery magnetic absorption layer is opposite to the isolation magnetic absorption layer in magnetism.
The present disclosure also provides a system, comprising: a ventricular isolation device as described above for releasing a spacer for ventricular isolation, and a retrieval device as described above for retrieving a spacer released by the ventricular isolation device.
The invention provides a recoverable ventricular isolation device, a recovery device and a system, wherein the ventricular isolation device comprises: a first device body and a spacer for isolating a ventricle; the first device body is provided with a containing cavity for containing the isolating piece; the containing cavity is internally provided with a push head, and the push head is connected with a push rod; an ejection outlet is formed in one end, opposite to the pushing head, of the containing cavity; the isolating piece comprises a recovery joint used for recovering the isolating piece, and a clamping groove is formed in the recovery joint. Through set up the draw-in groove on retrieving the joint, be convenient for retrieve the separator, avoided the risk that needs carry out the open chest operation.
Drawings
FIG. 1 is a perspective view of a preferred embodiment of a retrievable ventricular isolation device according to the invention;
FIG. 2 is a perspective view of a preferred embodiment of the spacer received in the receiving cavity of the present invention;
FIG. 3 is a perspective view of another preferred embodiment of a ventricular isolation device in accordance with the present invention;
FIG. 4 is a cross-sectional view of a preferred embodiment of the ventricular isolation device of the present invention pneumatically releasing the spacer;
FIG. 5 is a perspective view of a preferred embodiment of the recycling apparatus of the present invention;
FIG. 6 is a perspective view of a preferred embodiment of the recycling spacer of the recycling apparatus of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer and clearer, the present invention is further described in detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Referring to fig. 1 and 2, there are shown perspective views of a preferred embodiment of a retrievable ventricular isolation device of the present invention. As shown in fig. 1 and 2, a ventricular isolation device according to an embodiment of the present invention includes: the device comprises a first device body 1 and a containing cavity arranged in the first device body 1, wherein the containing cavity is used for containing a partition 4, and the first device body 1 is used for releasing the partition 4 contained in the containing cavity; the spacer 4 includes: the recovery joint 41, the supporting bone 42 and the coating layer; the recovery connector 41 is provided with a clamping groove 43, so that the isolating piece 4 is convenient to recover. Specifically, the partition 4 is closed when being accommodated in the accommodating cavity, as shown in fig. 2, and the partition 4 is opened when being pushed out of the accommodating cavity, as shown in fig. 1. It will be understood that the shape of the receiving cavity and the first device body 1 are not limited to a large extent, and may be cylindrical, polygonal or other irregular shapes, preferably cylindrical, to facilitate rapid delivery of the ventricular isolation device into the human ventricle.
Specifically, there are various ways of releasing the spacer 4 using the first device body 1, and the following description will be made by way of example, and it is to be understood that this example is only for explaining the present invention and is not intended to limit the present invention.
In one embodiment, the release of the spacer 4 is achieved by directly pushing the spacer 4 out of the receiving cavity. As shown in fig. 2, a partition 4 and a push head 2 are accommodated in the accommodating cavity, and the push head 2 is arranged at one end of the partition 4 and connected with a push rod 3; the isolation member 4 is used for isolating the ventricle; an ejection outlet is formed in one end, opposite to the pushing head 2, of the containing cavity. When the push head 2 pushes the partition 4 by controlling the push rod 3, the partition 4 is ejected from the accommodating cavity through the ejection outlet, so that the partition 4 is released through the first device body 1, and the partition 4 covers the ventricular wall to isolate the ventricle. Of course, the push rod 3 may be disposed in the accommodating cavity, or may be disposed outside the accommodating cavity, as long as it can push the push head 2, and the manner of disposing outside the accommodating cavity may refer to fig. 3.
Furthermore, the cross section of the push head 2 is larger than that of the push rod 3, so that on one hand, the whole volume of the ventricular isolation device is reduced, the ventricular isolation device is convenient to apply to minimally invasive intervention operation, and on the other hand, the isolation piece 4 can be easily pushed out. Of course, the push rod 3 can be made into a filament shape, so that the diameter of the push rod is greatly reduced, and the push rod is beneficial to entering a human body.
In another embodiment, the spacer 4 can be flushed out of the receiving chamber by creating an air flow by means of an increased air pressure, which does not require the push rod 3 to be sufficiently long. Specifically, as shown in fig. 4, the first device body 1 is further provided with a gas injection channel leading to the receiving cavity, the cross section of the gas injection channel is larger than that of the receiving cavity, and the outer edge of the push head 2 is attached to the inner wall of the gas injection channel.
Further, the pushing head 2 may be made of a rubber material to ensure the sealing property of the gas injection channel.
In this way, the visible barrier 4 is released to cover the ventricular wall directly, and the first device body 1 is delivered and removed through the aortic valve, leaving the barrier 4 in place on the body.
The invention also improves the isolation piece 4, in particular, the isolation piece 4 comprises a recovery joint 41, a plurality of supporting bones 42 and a coating layer coated on the supporting bones 42; the supporting ribs 42 are arranged at one end of the recovery joint 41 and are uniformly distributed along the circumferential direction of the recovery joint 41 to form an umbrella shape; the covering layer covers the supporting ribs 42 to form an umbrella surface of the supporting ribs 42.
Of course, the shape of the isolating member 4 is not limited in this embodiment, and it may be umbrella-shaped or trumpet-shaped, and as long as it is in the expanded state after being released, the purpose of isolating the ventricle can be achieved.
In one embodiment, the supporting bone 42 is made of nitinol, and the coating layer is made of teflon, wherein the supporting bone 42 made of nitinol has good plastic deformation, is wear-resistant, corrosion-resistant, and has high elasticity, and can be easily accommodated in or ejected from the accommodating cavity to automatically return to an open state; and the coating layer made of polytetrafluoroethylene has good chemical stability. Therefore, the separator 4 of the present invention can be stored in a human body for a long time without causing any harm to the human body, and is relatively environment-friendly.
Furthermore, in order to ensure the isolation area of the isolation member 4, the supporting ribs 42 made of nitinol have high elasticity, so that when the supporting ribs 42 are disposed at positions corresponding to the recovery joints 41, one ends of the supporting ribs 42 are uniformly disposed at the circumferential direction of the bottom ends or the side ends of the recovery joints 41, the recovery joints 41 are cylindrical, and the diameter of the circular surface formed by the ends of the supporting ribs 42 is larger than the diameter of the recovery joints 41; the diameter of the circular surface formed by the ends of the supporting ribs 42 can be adjusted by adjusting the length of the supporting ribs 42 or the included angle between the supporting ribs and the axis of the recovering joint 41.
In one embodiment, a fixing anchor is further provided at the distal end of the supporting bone 42 to realize the stable covering of the spacer 4 on the ventricular wall, specifically, a fixing anchor may be provided at the distal end of each or more supporting bones 42, and a fixing anchor on a plurality of supporting bones is provided at the opposite inner sides of the plurality of supporting bones; in addition, the anchor may be provided in the shape of a rivet, a barb, or a suction cup, wherein the suction cup has a minimal damage to the ventricle, and may be set according to the use requirement in a specific application, which is not limited herein.
In order to facilitate the recovery of the above-mentioned spacer 4, the present invention also provides a recovery apparatus, as shown in fig. 5, for recovering the spacer 4 released through the ventricular spacer, the recovery apparatus comprising: a hollow second device body 7, and a pull rod 6 and a recovery member 5 which are arranged in the hollow second device body 7; the recovering member 5 is disposed at one end of the pull rod 6, and is configured to be clamped with the clamping groove 43 to recover the isolating member 4, the pull rod 6 drives the recovering member 5 to move along the recovering passage formed by the hollow device body 1, so as to fold the isolating member 4 in the recovering passage, and a manner of recovering the isolating member 4 by using the recovering device is shown in fig. 6.
Certainly, the preferred scheme in the present invention is that the ventricular isolation device and the recovery device share the same device body, that is, the hollow second device body 7 can be used for accommodating the push rod 3 for pushing the isolation member 4, and also can be used for accommodating the pull rod 6 for recovering the isolation member 4, only the end of the push rod 3 is the push head 2, and the end of the pull rod 6 is the recovery member 5, and by replacing the push rod 3 and the pull rod 6 accommodated in the device body, the isolation member 4 can be released, and the isolation member 4 can be recovered, so that the cost is saved.
Further, the locking groove 43 may be opened on a side surface of the recovering joint 41, or may be opened on an end surface of the recovering joint 41 facing away from the supporting bone 42.
First, as shown in fig. 5, the catching groove 43 is opened at a side surface of the recovery connector 41, and the recovery member 5 has a ring shape so as to pull the isolation member 4 through the catching groove 43.
Scheme two, draw-in groove 43 sets up retrieve the joint 41 and deviate from the terminal surface of support bone 42, retrieve 5 with draw-in groove 43 riveting, it has set up an barb at least on the retrieve 5 to retrieve 5 block in draw-in groove 43.
It can be understood that the first scheme and the second scheme can coexist, and both pass through the clamping groove 43 on the side surface to pull the isolating piece 4 and are positioned through the clamping groove on the end surface to realize riveting, so that the annular recovering piece 5 is prevented from loosening when pulling the isolating piece 4.
In a preferred embodiment, the recovery member 5 is coated with a recovery magnetic layer and the slot 43 is coated with an isolation magnetic layer, which have opposite magnetism, for the purpose of accurately clamping the recovery member 5 to the slot 43 and tightly clamping the recovery member and the slot 43. Specifically, the magnetic absorption layer can be coated only on the contact part of the recovery part 5 and the clamping groove 43, so that the function of quick positioning can be achieved.
The present invention also provides a system comprising a ventricular isolation device as described above for releasing a spacer 4 for ventricular isolation and a retrieval device for retrieving the spacer 4 released by the ventricular isolation device; as described above.
In summary, the recoverable ventricular isolation device, the recovery device and the system disclosed by the present invention comprise: a first device body and a spacer for isolating a ventricle; the first device body is provided with a containing cavity for containing the isolating piece; the containing cavity is internally provided with a push head, and the push head is connected with a push rod; an ejection outlet is formed in one end, opposite to the pushing head, of the containing cavity; the isolating piece comprises a recovery joint used for recovering the isolating piece, and a clamping groove is formed in the recovery joint. The ventricular isolation device releases the isolation piece, and then the recovery device recovers the released isolation piece, so that the technical problem that the isolation piece cannot be recovered in the prior art is solved; meanwhile, the isolating piece can be automatically opened and closed, so that the operation process is convenient.
It is to be understood that the invention is not limited to the examples described above, but that modifications and variations may be effected thereto by those of ordinary skill in the art in light of the foregoing description, and that all such modifications and variations are intended to be within the scope of the invention as defined by the appended claims.
Claims (7)
1. A retrievable ventricular isolation device, comprising:
a first device body and a spacer for isolating a ventricle; the first device body is provided with a containing cavity for containing the isolating piece; the containing cavity is internally provided with a push head, and the push head is connected with a push rod; an ejection outlet is formed in one end, opposite to the pushing head, of the containing cavity; the first device body is provided with a gas injection channel, the cross section of the gas injection channel is larger than that of the containing cavity, and the inner wall of the gas injection channel is attached to the outer edge of the push head; the isolating piece comprises a recovery joint for recovering the isolating piece, and a clamping groove is formed in the recovery joint;
a plurality of supporting bones are arranged at one end of the recovery joint, the plane area formed by one end of each supporting bone far away from the recovery joint is larger than the cross section of the recovery joint, when the isolating piece is stored in the storage cavity, the recovery joint is positioned at one end close to the pushing head, and the supporting bones are positioned at one end close to the bullet outlet;
the one end that supports the bone and deviates from retrieve the joint is equipped with the anchor, and the anchor on many support bones sets up in the inboard of many support bones.
2. A retractable ventricular isolation device as claimed in claim 1, wherein the supporting bone is made of nitinol and is umbrella-shaped.
3. A recoverable ventricular isolation device according to claim 2, wherein the supporting bone is covered with a coating as an umbrella covering of the supporting bone, the coating being made of teflon.
4. A retrievable ventricular isolation system, comprising: a ventricular isolation device as claimed in any one of claims 1 to 3 for releasing a spacer for ventricular isolation; the recovery device is used for recovering the spacers released by the ventricular isolation device; the recovery device comprises: a hollow second device body and a recovery member; the second device body is internally provided with a pull rod and a recovery piece connected with the pull rod, and the recovery piece is clamped with the clamping groove.
5. A retractable ventricular isolation system as claimed in claim 4, wherein the slot opens to the side of the retrieval connector, the retrieval connector being annular.
6. A retractable ventricular isolation system as claimed in claim 4, wherein the catch slot opens onto an end face of the retrieval connector facing away from the supporting bone, and at least one barb is provided on the retrieval member for catching with the catch slot.
7. A recoverable ventricular isolation system according to claim 4, wherein the inside of the pockets are coated with an isolating magnetically attractive layer and the outside of the retrievers are coated with a recovery magnetically attractive layer of opposite polarity to the isolating magnetically attractive layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010236676.6A CN111513773B (en) | 2020-03-30 | 2020-03-30 | Recoverable ventricular isolation device, recovery device and system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010236676.6A CN111513773B (en) | 2020-03-30 | 2020-03-30 | Recoverable ventricular isolation device, recovery device and system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111513773A CN111513773A (en) | 2020-08-11 |
| CN111513773B true CN111513773B (en) | 2022-01-14 |
Family
ID=71901034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010236676.6A Active CN111513773B (en) | 2020-03-30 | 2020-03-30 | Recoverable ventricular isolation device, recovery device and system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111513773B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2455037A1 (en) * | 2003-03-27 | 2012-05-23 | Terumo Kabushiki Kaisha | Methods and apparatus for treatment of patent foramen ovale |
| CN105877794A (en) * | 2016-06-30 | 2016-08-24 | 湖南埃普特医疗器械有限公司 | Ventricular volume reduction device |
| CN106361381A (en) * | 2015-07-21 | 2017-02-01 | 深圳市科奕顿生物医疗科技有限公司 | Left ventricular volume reduction device |
| CN108143459A (en) * | 2016-12-02 | 2018-06-12 | 贤发科技有限公司 | Medical treatment isolation instrument |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7399271B2 (en) * | 2004-01-09 | 2008-07-15 | Cardiokinetix, Inc. | Ventricular partitioning device |
| CN203169800U (en) * | 2013-04-25 | 2013-09-04 | 潘湘斌 | Treatment guide device |
| CN108245292B (en) * | 2016-12-29 | 2019-11-08 | 先健科技(深圳)有限公司 | Conveying device and transportation system |
| CN209564156U (en) * | 2018-12-26 | 2019-11-01 | 福建医科大学附属协和医院 | A kind of heart atrial septal defect closer |
-
2020
- 2020-03-30 CN CN202010236676.6A patent/CN111513773B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2455037A1 (en) * | 2003-03-27 | 2012-05-23 | Terumo Kabushiki Kaisha | Methods and apparatus for treatment of patent foramen ovale |
| CN106361381A (en) * | 2015-07-21 | 2017-02-01 | 深圳市科奕顿生物医疗科技有限公司 | Left ventricular volume reduction device |
| CN105877794A (en) * | 2016-06-30 | 2016-08-24 | 湖南埃普特医疗器械有限公司 | Ventricular volume reduction device |
| CN108143459A (en) * | 2016-12-02 | 2018-06-12 | 贤发科技有限公司 | Medical treatment isolation instrument |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111513773A (en) | 2020-08-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11622874B2 (en) | Guide cap and loading system for loading implant into delivery system | |
| US11027103B2 (en) | Conduit device and system for implanting a conduit device in a tissue wall | |
| US20200397572A1 (en) | Transcatheter atrial sealing skirt, anchor, and tether and methods of implantation | |
| US11589985B2 (en) | Apparatus and methods for transfemoral delivery of prosthetic mitral valve | |
| US5976174A (en) | Medical hole closure device and methods of use | |
| US7785364B2 (en) | Kit to be implanted in a blood circulation conduit | |
| US10226333B2 (en) | Anatomically-orientated and self-positioning transcatheter mitral valve | |
| CN101636128B (en) | Stent-valves for valve replacement and associated methods and systems for surgery | |
| US20170065262A9 (en) | Devices and systems for inverting and closing the left atrial appendage | |
| EP2609888A1 (en) | Interventional medical device connector and method for using same | |
| US20170035433A1 (en) | Left atrial appendage occluder device anchoring system, anchor, and method of attachment | |
| JP2014529317A (en) | System for loading a foldable heart valve | |
| CN111513773B (en) | Recoverable ventricular isolation device, recovery device and system | |
| CN110947096B (en) | Cardiac pacing system and pacemaker fixing device | |
| US11589896B2 (en) | Tissue interface apparatus, systems, and methods | |
| JP6150533B2 (en) | Cardiac treatment device | |
| WO2023213106A1 (en) | Anchoring device of artificial heart valve and artificial heart valve system | |
| WO2023213107A1 (en) | Valve anchoring member and valve system | |
| EP4215160A1 (en) | Implant | |
| CN218739255U (en) | Implantable valve device | |
| WO2023183648A1 (en) | Clips implanted in the heart and great vessels that allow their complete or partial removal, kits and methods to perform such removal | |
| CN112438826A (en) | Valve prosthesis device for implanting into heart | |
| CN114903653A (en) | Aortic valve stent and system for delivering aortic valve stent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |