CN111471276A - Medical stomach tube material - Google Patents
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- CN111471276A CN111471276A CN202010335207.XA CN202010335207A CN111471276A CN 111471276 A CN111471276 A CN 111471276A CN 202010335207 A CN202010335207 A CN 202010335207A CN 111471276 A CN111471276 A CN 111471276A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/049—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L63/00—Compositions of epoxy resins; Compositions of derivatives of epoxy resins
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/18—Applications used for pipes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/03—Polymer mixtures characterised by other features containing three or more polymers in a blend
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Abstract
The invention discloses a medical gastric tube material, which adopts a material for a three-cavity two-balloon tube as a gastric tube material, and the preparation method of the material for the three-cavity two-balloon tube comprises the following steps: preparing a fluorine-containing polycondensate; (di) p-tolylene isocyanate modified fluorine-containing polycondensate; preparing a (tri) silafluorene triethanol oleic acid soap addition polymer; and (IV) material molding. The invention also discloses the material for the three-cavity two-sac tube prepared by the preparation method and the three-cavity two-sac tube adopting the material for the three-cavity two-sac tube as a gastric tube material. The medical gastric tube material disclosed by the invention has good biocompatibility and good rebound resilience and performance stability, and can greatly reduce the discomfort of a patient, relieve the pain of the patient and improve the success rate of rescue on the premise of not influencing the normal use of the three-cavity two-balloon tube device.
Description
The invention relates to a divisional application of a Chinese patent 'three-cavity two-sac tube material and a preparation method thereof', wherein the application date is 8 months and 31 days in 2018, and the application number is 201811006534. X.
Technical Field
The invention relates to the technical field of medicine, in particular to a material for a three-cavity two-sac tube and a preparation method thereof.
Background
In recent years, with the acceleration of life rhythm, the increase of working pressure and the continuous deterioration of ecological environment, the number of patients with liver cirrhosis tends to rise, and when the upper gastrointestinal tract hemorrhage caused by esophageal and fundus varicosis rupture caused by liver cirrhosis is treated, three-cavity two-sac tube compression hemostasis treatment is usually needed. The three-cavity two-sac tube consists of an esophagus sac, a stomach tube, an esophagus sac gas injection tube, a stomach sac gas injection tube and a suction port, and is the most direct and effective method for treating the massive hemorrhage of the digestive tract.
The three-cavity two-sac tube is made of elastic materials such as rubber, and the performance of the three-cavity two-sac tube directly influences the hemostasis effect and the success rate of rescue. The three-cavity two-sac tube used in the prior art is prepared from materials mainly comprising rubber, silica gel and latex, and when the three-cavity two-sac tube prepared from the materials is clinically applied, in the process of plugging the tube into the upper digestive tract of a patient, toxic and harmful substances are generated due to poor biocompatibility, insufficient elasticity or unstable performance and are decomposed, so that the tube is difficult to insert and can increase the pain of the patient; on the other hand, the friction generated in the forced insertion process can increase the bleeding volume of the patient, plays a certain side effect, and the patient can have strong rejection reaction after the insertion, thereby bringing pain to the patient in both physiology and mind.
In order to relieve the pain of patients during treatment, a lot of researches are made in the industry, the researches are mainly focused on improving and perfecting the structure of the three-cavity two-sac tube, the materials used are less researched, the three-cavity two-sac tube is directly plugged into the upper digestive tract of the patients and is in direct contact with the human body, the compatibility, the elasticity and the performance stability of the preparation materials are improved, the prevention of air leakage is also an effective method for relieving the pain of the patients and improving the hemostatic effect and the rescue success rate.
Therefore, the three-cavity two-sac tube with good biocompatibility, excellent rebound resilience and performance stability is developed to meet the market demand, and has wide market value and application prospect.
Disclosure of Invention
The invention aims to solve the problems and provides a material for a three-cavity two-sac tube and a preparation method thereof, the preparation method is simple and easy to implement, the used raw materials are low in price and easy to obtain, the prepared three-cavity two-sac tube has good biocompatibility and good rebound resilience and performance stability, the problems of poor treatment effect, untimely rescue and unsuccessful rescue caused by the reasons of air leakage of the device, difficulty in inserting the device into the digestive tract and the like can be effectively prevented, the discomfort of a patient can be greatly relieved on the premise of not influencing the normal use of the three-cavity two-sac tube device, and the pain of the patient is relieved.
In order to achieve the purpose, the invention adopts the technical scheme that the preparation method of the material for the three-cavity two-balloon tube comprises the following steps:
preparation of a fluorine-containing polycondensate: dissolving dimethylolhydantoin and 1, 4-bis (2',3' -epoxypropyl) perfluorobutane in a high-boiling-point solvent to form a solution, adding an alkaline catalyst into the solution, stirring the solution at 95-105 ℃ for reaction for 12-15 hours, precipitating the solution in ethanol, washing the precipitated polymer with ethanol for 3-5 times, and then placing the washed polymer in a vacuum drying oven for drying at 70-80 ℃ for 15-20 hours;
II, p-toluene isocyanate modified fluorine-containing polycondensate: dissolving the fluorine-containing polycondensate prepared in the step I and p-toluene isocyanate in dimethyl sulfoxide to form a solution, adding a catalyst, stirring at 80-90 ℃ for reacting for 8-10 hours, then precipitating in water, washing the precipitated polymer with ethanol for 4-6 times, and then placing the polymer in a vacuum drying oven for drying at 70-80 ℃ for 12-18 hours to obtain a p-toluene isocyanate modified fluorine-containing polycondensate;
III, preparation of silafluorene triethanol oleic acid soap addition polymer: dissolving 2- (2' -hydroxy-3 ' -methallyl-5 ' -methylphenyl) benzotriazole, methyl vinyl silafluorene, triethanolamine oleate and an initiator in N-methyl pyrrolidone, stirring and reacting for 3-5 hours at 70-80 ℃ in the atmosphere of nitrogen or inert gas, then precipitating in ethanol, and drying for 18-24 hours at 80-90 ℃ in a vacuum drying oven;
and IV, material forming: and (3) putting the p-toluene isocyanate modified fluorine-containing polycondensate prepared in the step (II), the thermoplastic elastomer SBS and the silafluorene triethanol oleic acid soap addition polymer prepared in the step (III) into a calendaring forming machine for calendaring forming to obtain the material for the three-cavity two-sac tube.
Preferably, the mass ratio of the dimethylolhydantoin, the 1, 4-bis (2',3' -epoxypropyl) perfluorobutane, the high-boiling-point solvent and the basic catalyst in the step I is 1:1.67 (10-15) to (0.4-0.6).
Preferably, the high boiling point solvent is selected from one or more of dimethyl sulfoxide, N-dimethylformamide and N-methylpyrrolidone.
Preferably, the basic catalyst is one or more selected from triphenylphosphine, triethylamine and tetrabutylammonium bromide.
Preferably, the mass ratio of the fluorine-containing polycondensate, the p-toluene isocyanate, the dimethyl sulfoxide and the catalyst in the step II is 1 (0.3-0.5) to (5-10) to (0.1-0.3).
Preferably, the catalyst is one or more selected from dibutyl dilaurate, stannous octoate, triethylamine and triethanolamine.
Preferably, in the step III, the mass ratio of the 2- (2' -hydroxy-3 ' -methallyl-5 ' -methylphenyl) benzotriazole to the methylvinyl silafluorene to the triethanolamine oleate to the initiator to the N-methylpyrrolidone is 0.2:1:1 (0.01-0.02) to (6-10).
Preferably, the initiator is selected from at least one of azobisisobutyronitrile and azobisisoheptonitrile; the inert gas is selected from one or more of helium, neon and argon.
Preferably, the mass ratio of the p-toluene isocyanate modified fluorine-containing polycondensate, the thermoplastic elastomer SBS and the silafluorene triethanol oleic acid soap addition polymer in the step IV is 1:0.7 (0.3-0.5).
Preferably, the calendering and molding process in the step IV is that the roller distance of a roller of the calender is 1.5-2.0mm, the surface temperature of an upper roller is 85-90 ℃, the surface temperature of a lower roller is 85-95 ℃, the running linear speed of the rubber compound is 0.25-0.3m/s, and the speed ratio of the roller is 1:1.05-1: 1.25.
The material for the three-cavity two-balloon tube is prepared by adopting the preparation method of the material for the three-cavity two-balloon tube.
A three-cavity two-sac tube adopts the material for the three-cavity two-sac tube as a stomach tube material.
Adopt the produced beneficial effect of above-mentioned technical scheme to lie in:
1) the material for the three-cavity two-sac tube provided by the invention is simple and feasible in preparation method, easy in raw material obtaining, low in cost and suitable for large-scale production.
2) The material for the three-cavity two-sac tube provided by the invention has good biocompatibility, good rebound resilience and good performance stability, can effectively prevent the problems of poor treatment effect, untimely rescue and unsuccessful rescue caused by air leakage of the device, difficulty in inserting into the digestive tract and the like, can greatly relieve the discomfort of a patient on the premise of not influencing the normal use of the three-cavity two-sac tube device, and relieves the pain of the patient.
3) According to the material for the three-cavity two-sac tube, the dimethylol hydantoin is introduced to the molecular main chain, so that the biocompatibility of the material is improved, the material is subjected to polycondensation reaction with 1, 4-bis (2',3' -epoxypropyl) perfluorobutane, and p-toluene isocyanate is added to modify the fluorine-containing polycondensate, so that a soft section and a hard section in the molecular structure alternately appear, and the excellent resilience of the material is ensured; through copolymerization of 2- (2' -hydroxy-3 ' -methallyl-5 ' -methylphenyl) benzotriazole, methyl vinyl silafluorene and triethanolamine oleate, a benzotriazole structure is introduced to improve the ultraviolet aging resistance of the material, a silafluorene structure and a triethanolamine structure are added to respectively form a hard section and a soft section, so that the resilience is improved, and the hydroxyl in the triethanolamine is easy to react with the epoxy group of a condensation polymer during molding, so that the performance stability and the tear resistance of the material are improved.
4) The material for the three-cavity two-sac tube is prepared by blending polycondensate, addition polymer and thermoplastic elastomer SBS, and has good compatibility among the components, and the prepared material has the advantages of the three different materials, so that the material has better comprehensive performance.
Detailed Description
In order to make the technical solutions of the present invention better understood and make the above features, objects, and advantages of the present invention more comprehensible, the present invention is further described with reference to the following examples. The examples are intended to illustrate the invention only and are not intended to limit the scope of the invention.
The raw material used in the following examples of the present invention was obtained from Shanghai spring Xin import & export trade company, Inc.
Example 1
A preparation method of a material for a three-cavity two-balloon tube comprises the following steps:
preparation of a fluorine-containing polycondensate: dissolving 100g of dimethylolhydantoin and 167g of 1, 4-bis (2',3' -epoxypropyl) perfluorobutane in 1000g of dimethyl sulfoxide to form a solution, adding 40g of triphenylphosphine into the solution, stirring the solution at 95 ℃ for reaction for 12 hours, precipitating the solution in ethanol, washing the precipitated polymer with ethanol for 3 times, and then placing the washed polymer in a vacuum drying oven for drying at 70 ℃ for 15 hours;
II, p-toluene isocyanate modified fluorine-containing polycondensate: dissolving 100g of the fluorine-containing polycondensate prepared in the step I and 30g of p-toluene isocyanate in 500g of dimethyl sulfoxide to form a solution, adding 10g of dibutyl dilaurate, stirring at 80 ℃ for reacting for 8 hours, precipitating in water, washing the precipitated polymer with ethanol for 4 times, and drying in a vacuum drying oven at 70 ℃ for 12 hours to obtain a p-toluene isocyanate modified fluorine-containing polycondensate;
III, preparation of silafluorene triethanol oleic acid soap addition polymer: dissolving 20g of 2- (2' -hydroxy-3 ' -methallyl-5 ' -methylphenyl) benzotriazole, 100g of methylvinyl silafluorene, 100g of triethanolamine oleate and 1g of azodiisobutyronitrile in 600g of N-methylpyrrolidone, stirring and reacting for 3 hours at 70 ℃ in a nitrogen atmosphere, precipitating in ethanol, and drying for 18 hours at 80 ℃ in a vacuum drying oven;
and IV, material forming: placing 100g of the p-toluene isocyanate modified fluorine-containing polycondensate prepared in the step II, the thermoplastic elastomer SBS70g and 30g of the silafluorene triethanol oleic acid soap addition polymer prepared in the step III into a calendaring forming machine for calendaring forming to obtain a material for a three-cavity two-sac tube; the calendering molding process comprises the steps of setting the roller distance of rollers of a calender to be 1.5mm, setting the surface temperature of an upper roller to be 85 ℃, setting the surface temperature of a lower roller to be 85 ℃, setting the running linear speed of the sizing material to be 0.25m/s and setting the speed ratio of the rollers to be 1: 1.05.
The material for the three-cavity two-balloon tube is prepared by adopting the preparation method of the material for the three-cavity two-balloon tube.
A three-cavity two-sac tube adopts the material for the three-cavity two-sac tube as a stomach tube material.
Example 2
A preparation method of a material for a three-cavity two-balloon tube comprises the following steps:
preparation of a fluorine-containing polycondensate: dissolving 100g of dimethylolhydantoin and 167g of 1, 4-bis (2',3' -epoxypropyl) perfluorobutane in 1100g of N, N-dimethylformamide to form a solution, adding 45g of triethylamine, stirring at 97 ℃ for reaction for 13 hours, precipitating in ethanol, washing the precipitated polymer with ethanol for 4 times, and then placing in a vacuum drying oven for drying at 73 ℃ for 16 hours;
II, p-toluene isocyanate modified fluorine-containing polycondensate: dissolving 100g of the fluorine-containing polycondensate prepared in the step I and 35g of p-toluene isocyanate in 600g of dimethyl sulfoxide to form a solution, adding 15g of stannous octoate, stirring and reacting at 83 ℃ for 8.5 hours, then precipitating in water, washing the precipitated polymer with ethanol for 5 times, and then drying in a vacuum drying oven at 73 ℃ for 13 hours to obtain a p-toluene isocyanate modified fluorine-containing polycondensate;
III, preparation of silafluorene triethanol oleic acid soap addition polymer: dissolving 20g of 2- (2' -hydroxy-3 ' -methallyl-5 ' -methylphenyl) benzotriazole, 100g of methylvinyl silafluorene, 100g of triethanolamine oleate and 1.3g of azodiisoheptanonitrile in 700g of N-methylpyrrolidone, stirring and reacting for 3.5 hours at 73 ℃ in a helium atmosphere, precipitating in ethanol, and drying for 19 hours at 83 ℃ in a vacuum drying oven;
and IV, material forming: placing 100g of the p-toluene isocyanate modified fluorine-containing polycondensate prepared in the step II, 70g g of thermoplastic elastomer SBS and 35g of the silafluorene triethanol oleic acid soap addition polymer prepared in the step III into a calendaring forming machine for calendaring forming to obtain a material for a three-cavity two-sac tube; the calendering molding process comprises the steps that the roller distance of rollers of a calender is 1.6mm, the surface temperature of an upper roller is 87 ℃, the surface temperature of a lower roller is 88 ℃, the running linear speed of the sizing material is 0.26m/s, and the speed ratio of the rollers is 1: 1.10.
The material for the three-cavity two-balloon tube is prepared by adopting the preparation method of the material for the three-cavity two-balloon tube.
A three-cavity two-sac tube adopts the material for the three-cavity two-sac tube as a stomach tube material.
Example 3
A preparation method of a material for a three-cavity two-balloon tube comprises the following steps:
preparation of a fluorine-containing polycondensate: dissolving 100g of dimethylolhydantoin and 167g of 1, 4-bis (2',3' -epoxypropyl) perfluorobutane in 1250g of N-methylpyrrolidone to form a solution, adding 50g of tetrabutylammonium bromide into the solution, stirring the solution at 99 ℃ for reacting for 13.5 hours, precipitating the solution in ethanol, washing the precipitated polymer with ethanol for 5 times, and then placing the washed polymer in a vacuum drying oven for drying at 76 ℃ for 18 hours;
II, p-toluene isocyanate modified fluorine-containing polycondensate: dissolving 100g of the fluorine-containing polycondensate prepared in the step I and 40g of p-toluene isocyanate in 800g of dimethyl sulfoxide to form a solution, adding 20g of triethylamine, stirring and reacting at 86 ℃ for 9 hours, precipitating in water, washing the precipitated polymer with ethanol for 6 times, and drying in a vacuum drying oven at 76 ℃ for 16 hours to obtain the p-toluene isocyanate modified fluorine-containing polycondensate;
III, preparation of silafluorene triethanol oleic acid soap addition polymer: dissolving 20g of 2- (2' -hydroxy-3 ' -methallyl-5 ' -methylphenyl) benzotriazole, 100g of methylvinyl silafluorene, 100g of triethanolamine oleate and 1.5g of azodiisobutyronitrile in 800g of N-methyl pyrrolidone, stirring and reacting for 4 hours at 78 ℃ in a neon atmosphere, precipitating in ethanol, and drying for 21 hours at 87 ℃ in a vacuum drying oven;
and IV, material forming: placing 100g of the p-toluene isocyanate modified fluorine-containing polycondensate prepared in the step II, the thermoplastic elastomer SBS70g and 40g of the silafluorene triethanol oleic acid soap addition polymer prepared in the step III into a calendaring forming machine for calendaring forming to obtain a material for a three-cavity two-sac tube; and IV, the calendering and molding process comprises the steps of setting the roll distance of a roller of the calender to be 1.7mm, setting the surface temperature of an upper roll to be 88 ℃, setting the surface temperature of a lower roll to be 90 ℃, setting the running linear speed of the rubber material to be 0.28m/s and setting the speed ratio of the roller to be 1: 1.15.
The material for the three-cavity two-balloon tube is prepared by adopting the preparation method of the material for the three-cavity two-balloon tube.
A three-cavity two-sac tube adopts the material for the three-cavity two-sac tube as a stomach tube material.
Example 4
A preparation method of a material for a three-cavity two-balloon tube comprises the following steps:
preparation of a fluorine-containing polycondensate: dissolving 100g of dimethylolhydantoin and 167g of 1, 4-bis (2',3' -epoxypropyl) perfluorobutane in 1450g of a high-boiling-point solvent to form a solution, adding 55g of a basic catalyst into the solution, stirring the solution at 103 ℃ for reaction for 14.5 hours, precipitating the solution in ethanol, washing the precipitated polymer with ethanol for 4 times, and then placing the washed polymer in a vacuum drying oven for drying at 79 ℃ for 18 hours; the high-boiling-point solvent is a mixture formed by mixing dimethyl sulfoxide, N-dimethylformamide and N-methylpyrrolidone according to the mass ratio of 2:1: 2; the alkaline catalyst is a mixture formed by mixing triphenylphosphine, triethylamine and tetrabutylammonium bromide according to the mass ratio of 1:2: 1;
II, p-toluene isocyanate modified fluorine-containing polycondensate: dissolving 100g of the fluorine-containing polycondensate prepared in the step I and 45g of p-toluene isocyanate in 95g of dimethyl sulfoxide to form a solution, adding 27g of a catalyst into the solution, stirring the solution at 88 ℃ for reaction for 9.5 hours, precipitating the solution in water, washing the precipitated polymer with ethanol for 6 times, and drying the washed polymer in a vacuum drying oven at 78 ℃ for 17 hours to obtain a p-toluene isocyanate modified fluorine-containing polycondensate; the catalyst is a mixture formed by mixing dibutyl dilaurate, stannous octoate, triethylamine and triethanolamine according to a mass ratio of 2:3:2: 1;
III, preparation of silafluorene triethanol oleic acid soap addition polymer: dissolving 20g of 2- (2' -hydroxy-3 ' -methallyl-5 ' -methylphenyl) benzotriazole, 100g of methylvinyl silafluorene, 100g of triethanolamine oleate and 1.9g of initiator in 950g of N-methyl pyrrolidone, stirring and reacting for 4.5 hours at the temperature of 79 ℃ in an argon atmosphere, precipitating in ethanol, and drying for 23 hours at the temperature of 89 ℃ in a vacuum drying oven; the initiator is a mixture formed by mixing azodiisobutyronitrile and azodiisoheptonitrile according to the mass ratio of 2: 1;
and IV, material forming: 100g of p-toluene isocyanate modified fluorine-containing polycondensate prepared in the step II, 70g of thermoplastic elastomer SBS and 45g of silafluorene triethanol oleic acid soap addition polymer prepared in the step III are placed in a calendaring forming machine for calendaring forming, so that the material for the three-cavity two-balloon tube is obtained; and IV, the calendering and molding process comprises the steps of setting the roller distance of rollers of the calender to be 1.9mm, setting the surface temperature of an upper roller to be 89 ℃, setting the surface temperature of a lower roller to be 94 ℃, setting the running linear speed of the rubber material to be 0.29m/s and setting the speed ratio of the rollers to be 1: 1.20.
The material for the three-cavity two-balloon tube is prepared by adopting the preparation method of the material for the three-cavity two-balloon tube.
A three-cavity two-sac tube adopts the material for the three-cavity two-sac tube as a stomach tube material.
Example 5
A preparation method of a material for a three-cavity two-balloon tube comprises the following steps:
preparation of a fluorine-containing polycondensate: dissolving 100g of dimethylolhydantoin and 167g of 1, 4-bis (2',3' -epoxypropyl) perfluorobutane in 1500g of dimethyl sulfoxide to form a solution, adding 60g of triethylamine, stirring at 105 ℃ for reaction for 15 hours, precipitating in ethanol, washing the precipitated polymer with ethanol for 5 times, and then drying in a vacuum drying oven at 80 ℃ for 20 hours;
II, p-toluene isocyanate modified fluorine-containing polycondensate: dissolving 100g of the fluorine-containing polycondensate prepared in the step I and 50g of p-toluene isocyanate in 1000g of dimethyl sulfoxide to form a solution, adding 30g of triethanolamine into the solution, stirring the solution at 90 ℃ for reaction for 10 hours, then precipitating the solution in water, washing the precipitated polymer with ethanol for 6 times, and then drying the washed polymer in a vacuum drying oven at 80 ℃ for 18 hours to obtain a p-toluene isocyanate modified fluorine-containing polycondensate;
III, preparation of silafluorene triethanol oleic acid soap addition polymer: dissolving 20g of 2- (2' -hydroxy-3 ' -methallyl-5 ' -methylphenyl) benzotriazole, 100g of methylvinyl silafluorene, 100g of triethanolamine oleate and 2g of azodiisoheptanonitrile in 1000g of N-methylpyrrolidone, stirring and reacting for 5 hours at 80 ℃ in a nitrogen atmosphere, precipitating in ethanol, and drying for 24 hours at 90 ℃ in a vacuum drying oven;
and IV, material forming: placing 100g of the p-toluene isocyanate modified fluorine-containing polycondensate prepared in the step II, the thermoplastic elastomer SBS70g and 50g of the silafluorene triethanol oleic acid soap addition polymer prepared in the step III into a calendaring forming machine for calendaring forming to obtain a material for a three-cavity two-sac tube; and IV, the calendering and molding process comprises the steps of enabling the roll distance of a roller of the calender to be 2.0mm, enabling the surface temperature of an upper roll to be 90 ℃, enabling the surface temperature of a lower roll to be 95 ℃, enabling the running linear speed of the rubber material to be 0.3m/s, and enabling the speed ratio of the roller to be 1: 1.25.
The material for the three-cavity two-balloon tube is prepared by adopting the preparation method of the material for the three-cavity two-balloon tube.
A three-cavity two-sac tube adopts the material for the three-cavity two-sac tube as a stomach tube material.
Comparative example
A silica gel material.
The materials prepared in the above examples and comparative examples were subjected to performance tests, and the test results and test standards are shown in table 1.
TABLE 1
| Item | Hemolysis ratio (%) | Tensile Property (MPa) | Elongation at Break (%) | Tear Strength (KN/m) |
| Test standard | ISOTR7405 | GB/T528-1998 | GB/T528-1998 | GB/T531-1999 |
| Example 1 | 0.16 | 98 | 940 | 35 |
| Example 2 | 0.14 | 100 | 948 | 36 |
| Example 3 | 0.13 | 103 | 955 | 38 |
| Example 4 | 0.11 | 104 | 963 | 39 |
| Example 5 | 0.10 | 106 | 970 | 40 |
| Comparative example | 0.45 | 92 | 930 | 26 |
As can be seen from the above Table 1, the materials for the three-cavity two-capsule tube prepared by the embodiments of the present invention have more excellent biocompatibility, resilience, stretching and tear resistance.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are merely illustrative of the principles of the invention, but that various changes and modifications may be made without departing from the spirit and scope of the invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. The medical gastric tube material is characterized in that a material for a three-cavity two-balloon tube is adopted as the gastric tube material, and the preparation method of the material for the three-cavity two-balloon tube comprises the following steps:
preparation of a fluorine-containing polycondensate: dissolving dimethylolhydantoin and 1, 4-bis (2',3' -epoxypropyl) perfluorobutane in a high-boiling-point solvent to form a solution, adding an alkaline catalyst into the solution, stirring the solution at 95-105 ℃ for reaction for 12-15 hours, precipitating the solution in ethanol, washing the precipitated polymer with ethanol for 3-5 times, and then placing the washed polymer in a vacuum drying oven for drying at 70-80 ℃ for 15-20 hours;
II, p-toluene isocyanate modified fluorine-containing polycondensate: dissolving the fluorine-containing polycondensate prepared in the step I and p-toluene isocyanate in dimethyl sulfoxide to form a solution, adding a catalyst, stirring at 80-90 ℃ for reacting for 8-10 hours, then precipitating in water, washing the precipitated polymer with ethanol for 4-6 times, and then placing the polymer in a vacuum drying oven for drying at 70-80 ℃ for 12-18 hours to obtain a p-toluene isocyanate modified fluorine-containing polycondensate;
III, preparation of silafluorene triethanol oleic acid soap addition polymer: dissolving 2- (2' -hydroxy-3 ' -methallyl-5 ' -methylphenyl) benzotriazole, methyl vinyl silafluorene, triethanolamine oleate and an initiator in N-methyl pyrrolidone, stirring and reacting for 3-5 hours at 70-80 ℃ in an inert gas atmosphere, precipitating in ethanol, and drying for 18-24 hours at 80-90 ℃ in a vacuum drying oven;
and IV, material forming: and (3) putting the p-toluene isocyanate modified fluorine-containing polycondensate prepared in the step (II), the thermoplastic elastomer SBS and the silafluorene triethanol oleic acid soap addition polymer prepared in the step (III) into a calendaring forming machine for calendaring forming to obtain the material for the three-cavity two-sac tube.
2. The material for the medical gastric tube as claimed in claim 1, wherein the mass ratio of the dimethylolhydantoin, the 1, 4-bis (2',3' -epoxypropyl) perfluorobutane, the high boiling point solvent and the basic catalyst in the step I is 1:1.67 (10-15) to (0.4-0.6).
3. The material for the medical gastric tube according to claim 1, wherein the high boiling point solvent is one or more selected from the group consisting of dimethylsulfoxide, N-dimethylformamide, and N-methylpyrrolidone; the basic catalyst is one or more selected from triphenylphosphine, triethylamine and tetrabutylammonium bromide.
4. The material for the medical gastric tube as claimed in claim 1, wherein the mass ratio of the fluorine-containing polycondensate, the p-toluene isocyanate, the dimethyl sulfoxide and the catalyst in the step II is 1 (0.3-0.5) to (5-10) to (0.1-0.3).
5. The material for the medical gastric tube according to claim 1, wherein the catalyst is one or more selected from dibutyl dilaurate, stannous octoate, triethylamine and triethanolamine.
6. The material for the medical gastric tube as claimed in claim 1, wherein the mass ratio of the 2- (2' -hydroxy-3 ' -methallyl-5 ' -methylphenyl) benzotriazole, the methylvinylsilfluorene, the triethanolamine oleate, the initiator and the N-methylpyrrolidone in the step III is 0.2:1:1 (0.01-0.02) to (6-10).
7. The material for a medical gastric tube according to claim 1, wherein the initiator is selected from at least one of azobisisobutyronitrile, azobisisoheptonitrile; the inert gas is selected from one or more of helium, neon and argon.
8. The material for the medical gastric tube as claimed in claim 1, wherein the mass ratio of the p-toluene isocyanate modified fluorine-containing polycondensate, the thermoplastic elastomer SBS and the silafluofen triethanol oleic acid soap addition polymer in the step IV is 1:0.7 (0.3-0.5); the calendering molding process comprises the steps of setting the roll distance of the rollers of the calender to be 1.5-2.0mm, setting the surface temperature of the upper roller to be 85-90 ℃, setting the surface temperature of the lower roller to be 85-95 ℃, setting the running linear speed of the rubber material to be 0.25-0.3m/s, and setting the speed ratio of the rollers to be 1:1.05-1: 1.25.
9. A material for three-lumen two-balloon tubing prepared by using the material for medical gastric tube according to any one of claims 1 to 8.
10. A three-lumen two-sac tube and a medical gastric tube which are prepared by adopting the medical gastric tube material of any one of claims 1 to 8.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010335207.XA CN111471276A (en) | 2018-08-31 | 2018-08-31 | Medical stomach tube material |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010335207.XA CN111471276A (en) | 2018-08-31 | 2018-08-31 | Medical stomach tube material |
| CN201811006534.XA CN109054305B (en) | 2018-08-31 | 2018-08-31 | Material for three-cavity two-capsule tube and preparation method thereof |
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| CN202010335207.XA Withdrawn CN111471276A (en) | 2018-08-31 | 2018-08-31 | Medical stomach tube material |
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| US7655805B2 (en) * | 2008-04-24 | 2010-02-02 | Ufc Corporation | Method for synthesizing benzotriazole |
| CN103153967A (en) * | 2010-10-25 | 2013-06-12 | 莱雅公司 | Process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds and process for preparing siloxane compounds containing 2-hydroxyphenyl benzotrizole function |
| CN104559312B (en) * | 2014-12-31 | 2017-07-14 | 丽王化工(南通)有限公司 | A kind of high-temperature resistant fluorescent pigment and preparation method thereof |
| CN105885039A (en) * | 2016-06-07 | 2016-08-24 | 黄山加佳荧光材料有限公司 | Preparation method of high-performance daylight type fluorescent pigment for powder coating |
| CN107641168B (en) * | 2016-07-20 | 2021-09-28 | 东莞东阳光医疗智能器件研发有限公司 | Polymer, preparation method and application thereof |
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| CN109054305A (en) | 2018-12-21 |
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