CN111471044A - Synthesis method of palladium-catalyzed 3-aryl 7-azaindole compound - Google Patents
Synthesis method of palladium-catalyzed 3-aryl 7-azaindole compound Download PDFInfo
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Abstract
A synthesis method of a palladium-catalyzed 3-aryl 7-azaindole compound comprises the steps of adding a 7-azaindole compound and an arylboronic acid compound into a reaction tube, adding a transition metal palladium catalyst, an oxidant, an alkali and a solvent, and reacting at 40-100 ℃ for 2-24 hours to obtain the 3-aryl 7-azaindole compound. In the invention, the reaction system does not need to be added with N-containing and P-containing ligands; in the invention, the protecting group at the N1 position in the 7-azaindole compound is not important, the existence of the protecting group does not have obvious influence on the activity and selectivity of the arylation reaction, and the reaction can selectively occur at the C3 position of the 7-azaindole compound; the invention uses arylboronic acid compounds as arylating reagents, so that the toxicity is obviously reduced, and halide with high pollution is not generated in the reaction process; the whole reaction process is simple, efficient, low in toxicity and convenient to operate.
Description
Technical Field
The invention relates to the field of organic synthesis, in particular to a synthesis method of a palladium-catalyzed 3-aryl 7-azaindole compound.
Background
7-azaindole (1H-pyrrolo [2, 3-b)]Pyridine) is an important group of aromatic organic compounds, the molecular structure of which widely exists in the core skeletons of natural products and bioactive compounds, 3-aryl-7-azaindoles have high biological activity as derivatives thereof (L. H.Franco, et al.J.Nat.Prod.1998,61,1130; N.B.Perry, et al.tetrahedron 1994,50, 3987; G.Trimuluulu, et al.tetrahedron 1994,50,3993)50Values (i.e. concentrations required to reduce cell proliferation by 50%) were as low as 0.18mM and 0.14mM, respectively (a. echalier, et. al. j. med. chem.2008,51,737). Therefore, the compounds have wide application prospect.
Review literature, there are two general routes to the synthesis of 3-aryl-7-azaindoles, the first being via intramolecular (S. L lona-Minguez, et. al. chem. eur. j.2015,21,7394) or intermolecular (t. bzeih, et. al. chem. commu.2016, 52,13027) cyclization under specific catalytic conditions, and the second being a C-C coupling reaction with 7-azaindole as a substrate under transition metal catalytic conditions.
For the second method, researchers have previously mainly used brominated aromatic hydrocarbons (Patent, repub. korean KongkaeTaeho Kongbo, KR 2015017260,16Feb 2015) or arylhydrazines (y. chen, et. al. adv. synth. catal.2013,355,711) as arylating agents under transition metal catalysis in 1, 10-phenanthroline (1,10-phen), 2 '-bipyridine (2, 2' -bipy) or triphenylphosphine (PPh)3) And the 3-position arylation reaction of the substrate molecule is realized under the assistance of N, P ligand. It is noted that in the preparation of the target compound, it is also possible to first react 7-azaindole with the iodinating agent N-iodosuccinimide (NIS) in the presence of a strong baseIodination at the 3-position, and then cross-coupling reaction with aryl boric acid compounds (G.Qian, et.al.org. L ett.2014,16,5294) or aryl iodides (E.Merkul, et.al.org.Biomol.chem.2011,9,3139) to obtain the target product, but in the reactions, a protective group is generally required to be introduced at the 1-position of 7-azaindole.
As described above, in the conventional reports, a highly toxic coupling reagent such as an arylhydrazine compound or a halogenated (Br or I) aromatic hydrocarbon is generally used, and a highly polluting halide is produced as a byproduct, and a ligand such as N, P is often added to the reaction system to promote the reaction, and some reaction conditions are severe and even need to be performed under anhydrous and anaerobic conditions, so that it is very important to develop a simple, efficient and low-toxic method for preparing a 3-aryl-7-azaindole compound.
Disclosure of Invention
The invention aims to provide a palladium-catalyzed synthesis method of a 3-aryl 7-azaindole compound, which is simple to operate and easy to control.
In order to achieve the purpose, the invention adopts the following technical scheme:
a synthesis method of a palladium-catalyzed 3-aryl 7-azaindole compound comprises the steps of adding a 7-azaindole compound and an arylboronic acid compound into a reaction tube, adding a transition metal palladium catalyst, an oxidant, an alkali and a solvent, and reacting at 40-100 ℃ for 2-24 hours to obtain the 3-aryl 7-azaindole compound.
In a further improvement of the invention, the 7-azaindole compound is 7-azaindole, 1-phenyl-7-azaindole or 1-benzyl-7-azaindole.
The invention is further improved in that the aryl boric acid compound is phenylboronic acid, 2-methylphenylboronic acid, 3-methylphenylboronic acid, 4-methylphenylboronic acid, 3-fluorophenylboronic acid, 4-chlorophenylboronic acid or 4-methoxyphenylboronic acid.
In a further development of the invention, the transition metal palladium catalyst is Pd (OAc)2、PdCl2Or Pd (TFA)2。
In a further development of the invention, the oxidizing agent isIs AgOAc, Cu (OAc)2、PhI(OAc)2Or Cu (OTf)2。
In a further development of the invention, the base is Cs2CO3Or K2CO3。
A further improvement of the invention is that the solvent is N-methylpyrrolidone, dimethylacetamide, toluene or mesitylene.
In a further development of the invention, the ratio of the amounts of substance of the 7-azaindole compounds to the arylphenylboronic acid compounds is 1: (1-3); the mass ratio of the 7-azaindole compound to the transition metal palladium catalyst is 1: (0.05-0.5); the mass ratio of the 7-azaindole compound to the oxidant is 1: (1-2); the mass ratio of the 7-azaindole compound to the base is 1: (1-2).
The invention further improves that when the content of the 7-azaindole compound is 0.2mmol, the dosage of the solvent is 1-2 m L.
Compared with the prior art, the invention has the following beneficial effects: the reaction mechanism of the invention is as follows: firstly activating a transition metal palladium catalyst by alkali to obviously enhance the electrophilic performance of the catalyst, then carrying out electrophilic reaction on the activated catalyst at the C3 site with higher electron cloud density of the 7-azaindole compound under the action of an oxidant to generate a 7-azaindole active intermediate, then carrying out addition reaction on the intermediate and an arylphenylboronic acid compound, and then carrying out reduction elimination under the action of alkali to finally obtain an arylation product at the C3 site of the 7-azaindole; in the invention, any ligand such as N, P is not required to be added; in the invention, the protecting group at the N1 position in the 7-azaindole compound is not important, the existence of the protecting group does not have obvious influence on the activity and selectivity of the arylation reaction, and the reaction can selectively occur at the C3 position of the 7-azaindole compound; compared with the prior aryl hydrazine compounds, halogenated aromatic hydrocarbons and the like, the aryl boric acid compound has obviously reduced toxicity and does not generate high-polluting halide in the reaction process; the whole reaction process is simple, efficient, low in toxicity and convenient to operate; the synthetic route has strong selectivity and high synthetic efficiency; the reaction raw materials are cheap and easy to obtain; has wide potential application prospect.
Detailed Description
In order to further understand the present invention, the following examples are further illustrated, which are only used for explaining the present invention and are not to be construed as limiting the scope of the present invention.
In the invention, a 7-azaindole compound and a phenylboronic acid compound are used as raw materials, a transition metal palladium salt is used as a catalyst, a certain amount of oxidant, alkali and solvent are added, and the reaction is carried out for a certain time at a certain temperature to obtain an arylation product at the C3 position of the 7-azaindole.
The reaction equation of a palladium-catalyzed synthesis method of a 3-aryl 7-azaindole compound is as follows:
adding a 7-azaindole compound and an arylboronic acid compound into a reaction tube, adding a transition metal palladium catalyst, an oxidant, an alkali and a solvent, reacting for 2-24 hours at 40-100 ℃, and performing aftertreatment to obtain a C3 arylation product of the 7-azaindole.
Wherein the 7-azaindole compound is 7-azaindole, 1-phenyl-7-azaindole or 1-benzyl-7-azaindole; the arylboronic acid compound is phenylboronic acid, 2-methylphenylboronic acid, 3-methylphenylboronic acid, 4-methylphenylboronic acid, 3-fluorophenylboronic acid, 4-chlorophenylboronic acid or 4-methoxyphenylboronic acid.
The catalyst is Pd (OAc)2、PdCl2And Pd (TFA)2One kind of (1).
The oxidant is AgOAc, Cu (OAc)2、PhI(OAc)2And Cu (OTf)2One kind of (1).
The alkali is Cs2CO3And K2CO3One kind of (1).
The solvent is one of N-methyl pyrrolidone (NMP), dimethyl acetamide (DMA), toluene (tolumen) and mesitylene (mesitylene).
The mass ratio of the 7-azaindole compound to the phenylboronic acid compound is 1: (1-3).
The mass ratio of the 7-azaindole compound to the catalyst is 1: (0.05-0.5).
The mass ratio of the 7-azaindole compound to the oxidant is 1: (1 to 2)
The mass ratio of the 7-azaindole compound to the base is 1: (1-2).
The amount of the solvent is 1-2 m L based on 0.2mmol of 7-azaindole compound.
The following are specific examples
Example 1
Catalytic synthesis method, in air atmosphere, adding 0.2mmol of 7-azaindole, 0.2mmol of phenylboronic acid and 0.01mmol of Pd (OAc) into a reaction tube of 15m L2，0.2mmol Cu(OAc)2，0.2mmol Cs2CO3N-methyl pyrrolidone 1m L, reacting for 24 hours at 40 ℃, cooling to room temperature after the reaction is finished, diluting the mixture with water (5m L), extracting with dichloromethane (10m L× 3), combining organic phases, washing the organic phases with saturated saline solution (5m L), adding anhydrous sodium sulfate for drying, filtering and concentrating, separating by column chromatography, purifying and separating the product by taking 300-400 mesh silica gel as a stationary phase and taking mixed solvents of ethyl acetate and petroleum ether with different proportions as eluents, concentrating and drying to obtain colorless oily substances, wherein the physical properties and the characterization data of the obtained compound are as follows:1H NMR(400MHz,Chloroform-d):12.53(s,1H),8.34(d,J＝5.7Hz,1H),8.00(dd,J＝7.8,1.3Hz,1H),7.93(d,J＝7.3Hz,2H),7.55(t,J＝7.7Hz,2H),7.43(t,J＝7.4Hz,1H),7.14(dd,J＝7.8,4.8Hz,1H),6.83(s,1H).13C NMR(100MHz,Chloroform-d):150.1,140.4,129.3,128.7,127.5,123.6,119.2,117.2,116.2,115.9,114.1ppm.HRESI-MS:[M+H]+Calcd.for C13H10N2195.0917；Found 195.0916.
example 2
The catalytic synthesis method comprises the steps of adding 0.2mmol of 7-azaindole, 0.6mmol of 2-methyl phenylboronic acid and 0.1mmol of PdCl into a reaction tube with the thickness of 15m of L in an air atmosphere2，0.4mmolAgOAc，0.4mmol Cs2CO3Dimethyl acetamide 2m L, reacting for 2 hours at 100 ℃, cooling to room temperature after the reaction is finished, diluting the mixture with water (5m L), extracting with dichloromethane (10m L× 3), combining organic phases, washing the organic phases with saturated saline solution (5m L), adding anhydrous sodium sulfate for drying, filtering and concentrating, separating by column chromatography, purifying and separating the product by taking 300-400 mesh silica gel as a stationary phase and taking mixed solvents of ethyl acetate and petroleum ether with different proportions as eluents, concentrating and drying to obtain colorless oily substances, wherein the physical properties and the characterization data of the obtained compound are as follows:1H NMR(400MHz,Chloroform-d):12.47(s,1H),8.31(d,J＝4.7Hz,1H),7.92(dd,J＝8.5Hz,1H),7.76(d,J＝9.0Hz,1H),7.40(d,J＝9.2Hz,1H),7.35–7.33(m,2H),7.15(m,1H),6.87(s,1H),2.23(s,3H)ppm.13C NMR(100MHz,Chloroform-d):147.8,141.4,139.2,137.6,131.7,128.9,125.6,124.5,119.2,118.2,117.8,115.9,105.6,27.1ppm.HRESI-MS:[M+H]+Calcd.for C13H10FN2209.1073；Found 209.1074.
example 3
Catalytic synthesis method, in air atmosphere, 0.2mmol of 7-azaindole, 0.4mmol of 4-methylphenylboronic acid and 0.02mmol of Pd (TFA) are added into a reaction tube of 15m L2，0.2mmol PhI(OAc)2，0.2mmol K2CO3Toluene 1m L, 80 ℃ for 12 hours, after the reaction has ended, cooling to room temperature, diluting the mixture with water (5m L), extracting with dichloromethane (10m L× 3), combining the organic phases, saturating the organic phase with foodWashing with saline (5m L), adding anhydrous sodium sulfate, drying, filtering, concentrating, separating by column chromatography, purifying and separating a product by taking 300-400-mesh silica gel as a stationary phase and taking mixed solvents of ethyl acetate and petroleum ether in different proportions as eluents, and concentrating and drying to obtain a colorless oily substance, wherein the physical properties and the characterization data of the obtained compound are as follows:1H NMR(400MHz,Chloroform-d):12.52(s,1H),8.35(d,J＝4.7Hz,1H),7.91(dd,J＝8.0Hz,2H),7.78(d,J＝9.4Hz,2H),7.33(m,1H),7.13(m,1H),6.92(s,1H),2.34(s,3H)ppm.13C NMR(100MHz,Chloroform-d):149.1,142.4,138.7,131.7,128.9,123.6,122.5,118.2,117.2,115.9,114.6,21.3ppm.HRESI-MS:[M+H]+Calcd.forC13H10FN2209.1073；Found 209.1075.
example 4
Catalytic synthesis method, in air atmosphere, adding 0.2mmol of 7-azaindole, 0.4mmol of 3-fluorobenzeneboronic acid and 0.01mmol of Pd (OAc) into a reaction tube with the thickness of 15m L2，0.2mmol Cu(OTf)2，0.2mmol Cs2CO3Mesitylene 1m L, reacting for 16 hours at 80 ℃, cooling to room temperature after the reaction is finished, diluting the mixture with water (5m L), extracting with dichloromethane (10m L× 3), combining organic phases, washing the organic phases with saturated saline solution (5m L), adding anhydrous sodium sulfate for drying, filtering and concentrating, separating by column chromatography, purifying and separating the product by taking silica gel with 300-400 meshes as a stationary phase and taking mixed solvents of ethyl acetate and petroleum ether with different proportions as eluents, concentrating and drying to obtain colorless oily substances, wherein the physical properties and the characterization data of the obtained compound are as follows:1H NMR(400MHz,Chloroform-d):12.80(s,1H),8.36(s,1H),8.01(d,J＝7.7Hz,1H),7.68(dd,J＝23.0,8.7Hz,2H),7.51(d,J＝6.2Hz,1H),7.21–7.07(m,2H),6.84(s,1H).13C NMR(100MHz,Chloroform-d):163.5,149.4,142.1,138.7,128.3,127.5,123.3,121.8,118.2,117.2,115.9,115.1,112.5ppm.HRESI-MS:[M+H]+Calcd.forC13H10FN2213.0823；Found 213.0825.
example 5
The catalytic synthesis method comprises the steps of adding 0.2mmol of 7-azaindole, 0.6mmol of 4-fluorobenzeneboronic acid and 0.02mmol of Pd (OAc) into a reaction tube with the thickness of 15m L in an air atmosphere2，0.4mmol Cu(OTf)2，0.2mmol Cs2CO3Toluene 2m L, reacting at 50 ℃ for 18 hours, cooling to room temperature after the reaction is finished, diluting the mixture with water (5m L), extracting with dichloromethane (10m L× 3), combining organic phases, washing the organic phases with saturated saline solution (5m L), adding anhydrous sodium sulfate for drying, filtering and concentrating, separating by column chromatography, purifying and separating the product by taking 300-400 mesh silica gel as a stationary phase and taking mixed solvents of ethyl acetate and petroleum ether with different proportions as eluents, concentrating and drying to obtain yellow oily substances, wherein the physical properties and the characterization data of the obtained compound are as follows:1H NMR(400MHz,Chloroform-d):12.82(s,1H),8.36(d,J＝4.7Hz,1H),7.94(dd,J＝8.3Hz,2H),7.76(d,J＝9.6Hz,2H),7.71(s,1H),7.14(s,1H),6.85(s,1H).13C NMR(100MHz,Chloroform-d):160.4,149.1,142.4,138.7,129.3,128.9,123.6,118.2,117.2,115.9,112.1ppm.HRESI-MS:[M+H]+Calcd.for C13H10FN2213.0823；Found 213.0823.
example 6
The catalytic synthesis method comprises the steps of adding 0.2mmol of 7-azaindole, 0.4mmol of 4-fluorobenzeneboronic acid and 0.02mmol of Pd (OAc) into a reaction tube with the thickness of 15m L in an air atmosphere2，0.2mmol Cu(OTf)2，0.2mmol Cs2CO3Toluene 1m L, 80 ℃ for 14 hours, after the reaction is complete, the mixture is cooled to room temperature, the mixture is diluted with water (5m L), extracted with dichloromethane (10m L× 3), the organic phases are combined, the organic phase is washed with saturated brine (5m L), and anhydrous sodium sulfate is added to dryDrying, filtering, concentrating, separating by column chromatography, purifying and separating the product by taking 300-400-mesh silica gel as a stationary phase and taking mixed solvents of ethyl acetate and petroleum ether in different proportions as eluents, concentrating and drying to obtain yellow oily substances. The physical properties and characterization data of the obtained compounds are as follows:1H NMR(400MHz,Chloroform-d):12.42(s,1H),8.34(d,J＝4.8Hz,1H),7.98(dd,J＝9.3Hz,2H),7.76(d,J＝8.6Hz,2H),7.75(s,1H),7.14(s,1H),6.55(s,1H).13C NMR(100MHz,Chloroform-d):149.1,142.4,138.7,129.3,128.9,128.3,123.6,118.2,117.2,115.9,112.1ppm.HRESI-MS:[M+H]+Calcd.for C13H10ClN2229.0527；Found 229.0526.
example 7
Catalytic synthesis method, in air atmosphere, adding 0.2mmol of 7-azaindole, 0.4mmol of 4-methoxyphenylboronic acid and 0.01mmol of Pd (OAc) into a reaction tube of 15m L2，0.2mmol Cu(OTf)2，0.2mmol Cs2CO3Toluene 1m L, reacting for 10 hours at 80 ℃, cooling to room temperature after the reaction is finished, diluting the mixture with water (5m L), extracting with dichloromethane (10m L× 3), combining organic phases, washing the organic phases with saturated saline solution (5m L), adding anhydrous sodium sulfate for drying, filtering and concentrating, separating by column chromatography, purifying and separating the product by taking 300-400 mesh silica gel as a stationary phase and taking mixed solvents of ethyl acetate and petroleum ether with different proportions as eluents, concentrating and drying to obtain yellow oily substances, wherein the physical properties and the characterization data of the obtained compound are as follows:1H NMR(400MHz,Chloroform-d):12.61(s,1H),8.39(d,J＝4.4Hz,1H),7.94(dd,J＝8.3Hz,2H),7.76(d,J＝9.6Hz,2H),7.33(m,1H),7.15(m,1H),6.87(s,1H),3.87(s,3H)ppm.13C NMR(100MHz,Chloroform-d):147.8,141.4,137.6,131.7,128.9,125.6,124.5,119.2,118.2,115.9,105.6,57.3ppm.HRESI-MS:[M+H]+Calcd.forC14H13N2O225.1022；Found 225.1022.
example 8
Catalytic synthesis method, in air atmosphere, adding 0.2mmol of 1-phenyl-7-azaindole, 0.6mmol of 4-fluorobenzeneboronic acid and 0.02mmol of Pd (OAc) into a reaction tube of 15m L2，0.2mmol Cu(OTf)2，0.2mmol Cs2CO3Toluene 1m L, reacting at 80 ℃ for 12 hours, cooling to room temperature after the reaction is finished, diluting the mixture with water (5m L), extracting with dichloromethane (10m L× 3), combining organic phases, washing the organic phases with saturated saline solution (5m L), adding anhydrous sodium sulfate for drying, filtering and concentrating, separating by column chromatography, purifying and separating the product by taking 300-400 mesh silica gel as a stationary phase and taking mixed solvents of ethyl acetate and petroleum ether with different proportions as eluents, concentrating and drying to obtain yellow oily substances, wherein the physical properties and the characterization data of the obtained compound are as follows:1H NMR(400MHz,Chloroform-d):8.31(d,J＝4.5Hz,1H),7.92(dd,J＝8.0Hz,1H),7.56(d,J＝7.3Hz,2H),7.50(d,J＝7.3Hz,2H),7.38(t,J＝7.4Hz,1H)7.30(d,J＝8.2Hz,2H),7.20(s,1H),7.15(m,2H),6.87(s,1H),5.54(s,2H)ppm.13C NMR(100MHz,Chloroform-d):162.9,148.0,142.4,137.6,130.7,129.3,128.3,122.9,125.6,121.5,120.7,119.2,116.8,115.9ppm.HRESI-MS:[M+H]+Calcd.for C19H14FN2289.1136；Found 289.1135.
example 9
Catalytic synthesis method, in air atmosphere, adding 0.2mmol of 1-benzyl-7-azaindole, 0.6mmol of 4-fluorobenzeneboronic acid and 0.02mmol of Pd (OAc) into a reaction tube of 15m L2，0.4mmol Cu(OTf)2，0.2mmol Cs2CO3Toluene 2m L, 80 ℃ for 4 hours, after the reaction was complete, the mixture was cooled to room temperature, diluted with water (5m L), extracted with dichloromethane (10m L× 3), the organic phases were combined and the organic phase was saturated brine(5m L), adding anhydrous sodium sulfate, drying, filtering, concentrating, separating by column chromatography, using 300-400 mesh silica gel as a stationary phase, using mixed solvents of ethyl acetate and petroleum ether in different proportions as eluents to purify and separate the product, concentrating and drying to obtain yellow oily matter, wherein the physical properties and characterization data of the obtained compound are as follows:1H NMR(400MHz,Chloroform-d):8.30(d,J＝4.9Hz,1H),8.00(dd,J＝8.0Hz,1H),7.66(d,J＝7.3Hz,2H),7.58(t,J＝7.4Hz,1H),7.50(d,J＝7.3Hz,2H),7.40(d,J＝9.2Hz,2H),7.20(s,1H),7.15(m,2H),6.87(s,1H)ppm.13C NMR(100MHz,Chloroform-d):162.9,148.0,142.4,137.6,130.7,129.3,128.3,122.9,125.6,121.5,120.7,119.2,116.8,115.9ppm.HRESI-MS:[M+H]+Calcd.for C20H16FN2303.1292；Found303.1293.
example 10
Adding 7-azaindole and 3-methylphenylboronic acid into a reaction tube, wherein the amount of substances of the 7-azaindole is 0.2mol, and the ratio of the amounts of the substances is 1: 2, adding a catalyst, an oxidant and alkali, and reacting for 8 hours at 100 ℃ to obtain a C3-site arylation product, namely a 3-aryl 7-azaindole compound;
wherein the solvent is N-methylpyrrolidone, and the dosage of the N-methylpyrrolidone is 2m L.
The catalyst is Pd (TFA)2The mass ratio of the 7-azaindole to the catalyst is 1: 0.3.
the oxidant is AgOAc, the mass ratio of the 7-azaindole to the oxidant is 1: 1.5.
the alkali is Cs2CO3The mass ratio of the 7-azaindole to the base is 1: 2.
the foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, modifications and decorations can be made without departing from the core technology of the present invention, and the modifications and decorations shall also fall within the scope of the patent protection of the present invention. Any changes which come within the meaning and range of equivalency of the claims are to be embraced within their scope.
Claims (9)
1. A synthesis method of a palladium-catalyzed 3-aryl 7-azaindole compound is characterized by adding a 7-azaindole compound and an arylboronic acid compound into a reaction tube, adding a transition metal palladium catalyst, an oxidant, an alkali and a solvent, and reacting at 40-100 ℃ for 2-24 hours to obtain the 3-aryl 7-azaindole compound.
2. The palladium-catalyzed method of synthesizing a 3-aryl 7-azaindole compound according to claim 1, wherein: the 7-azaindole compound is 7-azaindole, 1-phenyl-7-azaindole or 1-benzyl-7-azaindole.
3. The palladium-catalyzed method of synthesizing a 3-aryl 7-azaindole compound according to claim 1, wherein: the arylboronic acid compound is phenylboronic acid, 2-methylphenylboronic acid, 3-methylphenylboronic acid, 4-methylphenylboronic acid, 3-fluorophenylboronic acid, 4-chlorophenylboronic acid or 4-methoxyphenylboronic acid.
4. The process of claim 1, wherein the transition metal palladium catalyst is Pd (OAc)2、PdCl2Or Pd (TFA)2。
5. The palladium-catalyzed method of synthesizing a 3-aryl 7-azaindole compound according to claim 1, wherein: the oxidant is AgOAc, Cu (OAc)2、PhI(OAc)2Or Cu (OTf)2。
6. The palladium-catalyzed method of synthesizing a 3-aryl 7-azaindole compound according to claim 1, wherein: the alkali is Cs2CO3Or K2CO3。
7. The palladium-catalyzed synthesis method of a 3-aryl 7-azaindole compound according to claim 1, wherein the solvent is N-methylpyrrolidone, dimethylacetamide, toluene, or mesitylene.
8. The palladium-catalyzed method of synthesizing a 3-aryl 7-azaindole compound according to claim 1, wherein: the mass ratio of the 7-azaindole compound to the arylphenylboronic acid compound is 1: (1-3); the mass ratio of the 7-azaindole compound to the transition metal palladium catalyst is 1: (0.05-0.5); the mass ratio of the 7-azaindole compound to the oxidant is 1: (1-2); the mass ratio of the 7-azaindole compound to the base is 1: (1-2).
9. The palladium-catalyzed synthesis method of the 3-aryl 7-azaindole compound as claimed in claim 1, wherein the amount of the solvent is 1-2 m L when the amount of the 7-azaindole compound is 0.2 mmol.
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