CN111449777A - 3D printing dental implant and preparation method and application thereof - Google Patents
3D printing dental implant and preparation method and application thereof Download PDFInfo
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- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
- A61C8/0013—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy with a surface layer, coating
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- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
- A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
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Abstract
The invention belongs to the technical field of false teeth, and particularly relates to a 3D printing tooth implant and a preparation method and application thereof, wherein the tooth implant comprises a substrate consisting of a base station and a tooth root, the surface of the substrate is provided with a micron-sized hole structure, the inner surface of the hole structure is an uneven structure, the surface of the tooth root and the micro-hole structure are provided with hydroxyapatite coatings, the interior of the hydroxyapatite coatings is provided with a fluorine-containing ion coating, and a transition layer containing fluorine ions is formed between the hydroxyapatite coating of the fluorine-containing ion coating and the micro-hole; the surface of the fluoride ion-containing coating layer is provided with external threads. The dental implant provided by the invention is a multilayer structure with a hydroxyapatite coating and a fluoride ion coating by taking a 3D printed titanium alloy as a substrate, and the dental implant with the structure has good mechanical properties, proper hardness, good biocompatibility and good antibacterial performance.
Description
Technical Field
The invention belongs to the technical field of false teeth, and particularly relates to a 3D printed tooth implant and a preparation method and application thereof.
Background
The information disclosed in this background of the invention is only for enhancement of understanding of the general background of the invention and is not necessarily to be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person skilled in the art.
The 3D printing is a method for manufacturing a solid model by using three-dimensional data, a reconstructed three-dimensional digital model is segmented into layers and then stacked layer by layer to form the solid model, and the method belongs to a rapid prototyping technology. With the development of optical scanning technology and digital technology, the application of 3D printing in dental implant restoration, and the preparation of dental restoration by using 3D printing technology becomes a new application in the dental industry. By combining the use of mouth scanning, CAD/CAM design and 3D printing, dental clinics, laboratories or manufacturing enterprises can accurately and quickly produce a range of products such as crowns, bridges, dental models, etc. Compared with the traditional manufacturing method, the 3D printing technology has the following maximum advantages: (1) the error of manual operation can be reduced through a digital scanning mode, so that the accuracy of initial data is improved, and a precondition is provided for accurately preparing a restoration body; (2) the model data is received and processed by the computer, so that the final prosthesis can be virtualized, and the communication with a patient can be conveniently realized before implantation; (3) through 3D printing, the data designed by a computer are directly 'stacked' and printed into a three-dimensional finished product, and compared with the traditional methods such as cutting and smelting, the method has the advantages of higher speed and higher precision, and saves the material cost.
Currently, the main applications of 3D printing for oral implant restoration include:
(1) manufacturing a pile core and a crown bridge;
(2) manufacturing removable partial dentures;
(3) manufacturing complete dentures;
(4) the application in planting and repairing.
The 3D printing technology is applied to the field of medical dental implants, accuracy of dental implantation is improved, cost is reduced, the implantation period is shortened, and implantation safety and implantation effect are improved.
Disclosure of Invention
Aiming at the prior art, the invention discovers that the prior tooth implant generally has certain compatibility, but the smooth structure of the surface of the tooth implant determines that the tooth implant can generate gaps with bone tissues in the process of implantation and recovery, cannot be quickly combined with a human body, is easy to loose in connection and poor in stability, and the longer recovery time also increases the treatment period of a patient, potential complications, bacterial infection and other problems, so that the inflammation around the implant is caused, the loss of an osseous combination interface finally occurs, and the artificial tooth implantation fails. In order to solve the above problems, the present invention provides a 3D printed dental implant, a method for preparing the same, and an application thereof. The dental implant provided by the invention is a multilayer structure with a hydroxyapatite coating and a fluoride ion coating by taking a 3D printed titanium alloy as a substrate, and the dental implant with the structure has good mechanical property, suitable hardness, a porous surface easy for cell adhesion, and good biocompatibility and antibacterial property. In order to achieve the above purpose, the invention discloses the following technical scheme.
The invention discloses a 3D printing dental implant, which comprises a substrate consisting of a base station and a tooth root, wherein the surface of the substrate is provided with a micron-sized hole structure, the inner surface of the hole structure is of an uneven structure, the surface of the tooth root and the hole structure are provided with hydroxyapatite coatings, the inside of the hydroxyapatite coatings and the shape of micropores of the substrate are provided with fluorine ion-containing coatings, and a transition layer containing fluorine ions is formed between the fluorine ion-containing coatings and the hydroxyapatite coatings; the surface of the fluoride ion-containing coating layer is provided with external threads.
As a further technical scheme, the abutment and the tooth root are both made of Ti-13Nb-13Zr, and the titanium alloy has good mechanical property, biological corrosion resistance, high fatigue strength, low elastic modulus and biocompatibility, is suitable for being used as a base material of the false tooth and ensures good mechanical property and corrosion resistance of the false tooth.
As a further technical scheme, the component of the fluorine ion-containing coating is metal fluoride. The sprayed hydroxyapatite coating covers the outside of the micro-holes, the micro-holes provide the attachment appearance of the micro-holes for the hydroxyapatite, and the fluoride ion coating and the hydroxyapatite coating cooperate together, so that the adhesion of gingival bacteria can be inhibited, the thallus form of the gingival bacteria can be influenced, the antibacterial property can be improved, the problems of implant loosening, falling and the like caused by the bacteria can be reduced, cells can be favorably attached to the appearance of the micro-holes, the postoperative recovery effect can be improved, and the postoperative recovery time can be shortened.
As a further technical scheme, the thickness of the coating containing the fluoride ions is within the range of 200-400 μm, the thickness of the hydroxyapatite coating is within the range of 100-130 μm, the coating containing the fluoride ions is combined in the shapes of micropores of the hydroxyapatite coating and the substrate, the hydroxyapatite coating has no obvious influence on the shape of the micropores, and the thickness of the fluoride ion layer is larger than that of the hydroxyapatite coating, so that the transition environment for combining the hydroxyapatite coating and the substrate can be improved.
In a second aspect of the present invention, a method for preparing a 3D-printed dental implant is disclosed, comprising the steps of:
(1) printing a matrix consisting of a base station and a tooth root by adopting a 3D printing technology, and then annealing the matrix to obtain a modified matrix;
(2) carrying out sand blasting treatment on the surface of the modified substrate, then carrying out acid etching treatment, and cleaning and drying after the acid etching treatment to obtain a precursor substrate;
(3) firstly preparing a hydroxyapatite coating on the precursor substrate, and then preparing a fluorine-containing ion coating inside the hydroxyapatite coating to obtain the coating.
As a further technical scheme, in the step (1), before a substrate is printed, a printing model is scanned, then printing model data is obtained by using MIMICS software for analysis and 3D model establishment, and finally the model data is digitized by Magic software and is led into a 3D printer.
As a further technical scheme, in the step (1), Ti-13Nb-13Zr is used as a printing material, and the parameters of 3D printing are as follows: the laser power is between 300 and 400W, the scanning speed is 100 and 200mm/s, the powder spreading thickness is 30-40 μm, and the thread pitch is 750 and 800 μm. The 3D printing technology can manufacture the dental implant according to the individual requirements of the patient, and is beneficial to reducing the alveolar bone loss of the patient, shortening the treatment period and relieving the inconvenience of the patient during the period without teeth.
As a further technical solution, in the step (1), the annealing process is: keeping the temperature at 750 ℃ and 800 ℃ for 20-25min, and then cooling to room temperature. The annealing process can reduce tissue defects in the printing process, reduce internal stress between tissues and improve the service life and safety of teeth.
As a further technical scheme, in the step (2), the sandblasting treatment is carried out by taking carborundum as sandblasting, vertically spraying for 10-30s under the pressure of 0.3-1.5MPa, wherein the spraying distance is 5-12cm, and ultrasonically cleaning and drying the sandblasted substrate by acetone, absolute ethyl alcohol and deionized water in sequence to obtain the composite material. After sand blasting, the surface of the substrate forms a honeycomb-shaped hole structure similar to a metal sample lifting fracture, the structural form is combined with the hydroxyapatite coating to be favorable for combining and harmonizing with human tissues and organs, and the pores between the honeycombs are favorable for the growth of alveolar bone soft tissues, so that the body part is tightly combined with the alveolar bone.
As a further technical solution, in the step (2), the acid etching treatment is: and placing the modified substrate in a mixed solution of a dilute hydrochloric acid solution and a dilute sulfuric acid solution for corrosion for 2-2.5h, cleaning with deionized water, and blow-drying to obtain the precursor substrate. The titanium alloy surface after acid etching treatment has higher surface energy, and macromolecules are easier to adsorb, bend and deform, so that attachment points are increased. In addition, the sand blasting and acid etching treatment can strengthen the corrosion resistance of the surface of the substrate.
As a further technical scheme, in the step (3), the hydroxyapatite coating is prepared by adopting a plasma spraying technology, which specifically comprises the following steps: hydroxyapatite (HA) powder is used as a spraying material, and the spraying power is 80-85W, N2-H2Spraying environment, feeding speed of 30-35g/min, spraying distance of 80-100mm, and spraying for 2-3 times. The hydroxyapatite coating is helpful for improving biocompatibility, biological affinity, biological activity, high stability and enough mechanical properties.
As a further technical scheme, in the step (3), the fluorine-containing ion coating is prepared by adopting a plasma spraying technology, which specifically comprises the following steps: cleaning the substrate with anhydrous alcohol, placing in vacuum chamber, and Ar treating before ion implantation+Sputter cleaning, finally with CF4And (5) spraying for 6-7h as an ion implantation source to obtain the nano-silver/nano-. The fluoride ion coating can inhibit adhesion of gingival bacteria and influence the thallus form, improve antibacterial property, reduce implant loosening and falling caused by bacteria, and is beneficial to postoperative recovery.
Finally, the invention discloses the use of the 3D printed dental implant in the medical field.
Compared with the prior art, the invention has the following beneficial effects:
(1) the technology of sand blasting, acid etching and hydroxyapatite coating plasma spraying adopted by the invention can construct a honeycomb-shaped micropore structure on the surface of the implant, the structural form is combined with the hydroxyapatite coating to be beneficial to combining and harmonizing with tissues and organs of a human body, and the pores among the honeycombs are beneficial to the adhesion of alveolar bone cells and the growth of soft tissues, so that the body part is tightly combined with the alveolar bone;
(2) the fluoride ion coating and the hydroxyapatite coating are cooperated together, so that the adhesion of gingival bacteria can be inhibited, the thallus form of the gingival bacteria can be influenced, the antibacterial property is improved, the problems of implant loosening, falling and the like caused by bacteria are solved, cells can be favorably attached to the shape of a micropore, the operation safety is improved, the success rate is improved, and the postoperative recovery time is favorably shortened;
(3) the addition of the annealing process reduces the tissue defects in the printing process, reduces the internal stress between tissues, and improves the service life and the safety of teeth.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the invention and together with the description serve to explain the invention and not to limit the invention.
Fig. 1 is a schematic structural view of a 3D-printed dental implant according to an embodiment of the present invention, in which reference numeral 1 represents an abutment, reference numeral 2 represents a root, reference numeral 3 represents an external thread, reference numeral 4 represents a coating layer containing fluoride ions, and reference numeral 5 represents a hydroxyapatite coating layer.
Detailed Description
It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the invention. As used herein, the singular forms also are intended to include the plural forms as well, unless the context clearly indicates otherwise, and it should be further understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of the stated features, steps, operations, devices, components, and/or combinations thereof.
The invention will now be further described with reference to the accompanying drawings and detailed description.
First embodiment referring to fig. 1, a method for preparing a 3D-printed dental implant includes the steps of:
(1) obtaining denture dimension information: and (3) performing topography scanning on CT data of the contralateral tooth of the denture by using a laser scanning device and the like, acquiring object data by using MIMICS software, performing data analysis, establishing a 3D model, and digitally importing the model data into a 3D printer by using Magic software.
(2) The Ti-13Nb-13Zr titanium alloy is used as a base material printing base of the dental implant, and the printing parameters of a 3D printer are as follows: the laser power is 300W, the scanning speed is 100mm/s, the powder spreading thickness is 30 mu m, the thread pitch of the dental implant is 750 mu m, the obtained matrix consists of an upper abutment 1 and a lower tooth root 2, and the abutment 1 and the tooth root 2 are integrally printed.
(3) And (3) keeping the temperature of the substrate in the step (2) at 750 ℃ for 25min, then cooling the substrate in the air to room temperature to obtain a modified substrate, wherein the annealing treatment is helpful for eliminating internal tissue stress in the substrate, and reducing tissue defects to obtain the denture with the surface hardness of 290 HV.
(4) Carrying out sand blasting and acid etching treatment on the modified matrix: firstly, carborundum with the grain diameter of 65 mu m is adopted to vertically spray the surface of a modified matrix for 20s under the air pressure of 0.4MPa, the spraying distance is 10cm, and the modified matrix after sand blasting is ultrasonically cleaned for 15min by acetone, absolute ethyl alcohol and deionized water in sequence and then is dried at room temperature. And then, taking a mixed solution formed by mixing a hydrochloric acid solution (the mass fraction of 18%) and a sulfuric acid solution (the mass fraction of 48%) in equal volumes as an acid etching treatment solution, putting the matrix subjected to sand blasting treatment into the acid etching treatment solution for corrosion for 2.5 hours, and after the corrosion is finished, washing the matrix with deionized water and drying the matrix for the next step. After sand blasting and acid etching treatment, a honeycomb-shaped micropore structure similar to a metal sample tensile fracture is formed on the surface of the substrate.
(5) And (4) carrying out plasma spraying on the matrix subjected to sand blasting and acid etching treatment in the step (4): firstly, adopting a plasma spraying technology, taking hydroxyapatite powder as a raw material, wherein the spraying power is 80W, the feeding speed is 30g/min, the spraying distance is 90mm, and the spraying speed is N2-H2Spraying for 2 times in a spraying environment to form a hydroxyapatite coating 5 with the thickness of 100 mu m on the surface. Cleaning the substrate coated with hydroxyapatite coating with anhydrous ethanol for 20min, placing in a vacuum chamber, and subjecting to Ar treatment before ion implantation+Sputter cleaning for 10min, and finally using CF4Spraying for 6h as ion implantation source to form a layer of fluorine-containing material with thickness of 200 μm on the surface of the implantAnd (4) an ionic coating 4 (the component is metal fluoride).
Second embodiment referring to fig. 1, a method for preparing a 3D-printed dental implant includes the steps of:
(1) obtaining denture dimension information: and (3) performing topography scanning on CT data of the contralateral tooth of the denture by using a laser scanning device and the like, acquiring object data by using MIMICS software, performing data analysis, establishing a 3D model, and digitally importing the model data into a 3D printer by using Magic software.
(2) The Ti-13Nb-13Zr titanium alloy is used as a base material printing base of the dental implant, and the printing parameters of a 3D printer are as follows: the laser power is 350W, the scanning speed is 200mm/s, the powder laying thickness is 34 mu m, the thread pitch of the dental implant is 770 mu m, the obtained matrix consists of an upper abutment 1 and a lower tooth root 2, and the abutment 1 and the tooth root 2 are integrally printed.
(3) And (3) keeping the temperature of the matrix in the step (2) at 800 ℃ for 20min, then cooling the matrix in the air to room temperature to obtain a modified matrix, wherein the annealing treatment is helpful for eliminating internal tissue stress in the matrix and reducing tissue defects to obtain the denture with the surface hardness of 265 HV.
(4) Carrying out sand blasting and acid etching treatment on the modified matrix: firstly, carborundum with the grain diameter of 65 mu m is adopted to vertically spray the surface of a modified matrix for 30s under the air pressure of 0.3MPa, the spraying distance is 5cm, and the modified matrix after sand blasting is ultrasonically cleaned for 15min by acetone, absolute ethyl alcohol and deionized water in sequence and then is dried at room temperature. And then, taking a mixed solution formed by mixing a hydrochloric acid solution (the mass fraction of 18%) and a sulfuric acid solution (the mass fraction of 48%) in equal volumes as an acid etching treatment solution, putting the matrix subjected to sand blasting treatment into the acid etching treatment solution for corrosion for 2.5 hours, and after the corrosion is finished, washing the matrix with deionized water and drying the matrix for the next step. After sand blasting and acid etching treatment, a honeycomb-shaped micropore structure similar to a metal sample tensile fracture is formed on the surface of the substrate.
(5) And (4) carrying out plasma spraying on the matrix subjected to sand blasting and acid etching treatment in the step (4): firstly, adopting a plasma spraying technology, taking hydroxyapatite powder as a raw material, wherein the spraying power is 82W, the feeding speed is 35g/min, the spraying distance is 80mm, and the spraying speed is N2-H2Spray ringSpraying for 3 times in the environment, and sequentially forming a hydroxyapatite coating 5 with the thickness of 120 mu m on the surface of the coating. Cleaning the substrate coated with hydroxyapatite coating with anhydrous ethanol for 20min, placing in a vacuum chamber, and subjecting to Ar treatment before ion implantation+Sputter cleaning for 10min, and finally using CF4Spraying for 7h as ion implantation source to form a layer of coating 4 (metal fluoride) containing fluorine ions with thickness of 300 μm on the surface of the implant.
Third embodiment referring to fig. 1, a method for preparing a 3D-printed dental implant includes the steps of:
(1) obtaining denture dimension information: and (3) performing topography scanning on CT data of the contralateral tooth of the denture by using a laser scanning device and the like, acquiring object data by using MIMICS software, performing data analysis, establishing a 3D model, and digitally importing the model data into a 3D printer by using Magic software.
(2) The Ti-13Nb-13Zr titanium alloy is used as a base material printing base of the dental implant, and the printing parameters of a 3D printer are as follows: the laser power is 400W, the scanning speed is 120mm/s, the powder laying thickness is 40 mu m, the thread pitch of the dental implant is 800 mu m, the obtained matrix consists of an upper abutment 1 and a lower tooth root 2, and the abutment 1 and the tooth root 2 are integrally printed.
(3) And (3) keeping the temperature of the matrix in the step (2) at 780 ℃ for 20min, then cooling the matrix in the air to room temperature to obtain a modified matrix, wherein annealing treatment is helpful for eliminating internal tissue stress in the matrix, and reducing tissue defects to obtain the denture with the surface hardness of 230 HV.
(4) Carrying out sand blasting and acid etching treatment on the modified matrix: firstly, carborundum with the grain diameter of 65 mu m is adopted to vertically spray the surface of a modified matrix for 10s under the air pressure of 1.5MPa, the spraying distance is 12cm, and the modified matrix after sand blasting is ultrasonically cleaned for 15min by acetone, absolute ethyl alcohol and deionized water in sequence and then is dried at room temperature. And then, taking a mixed solution formed by mixing a hydrochloric acid solution (the mass fraction of 18%) and a sulfuric acid solution (the mass fraction of 48%) in equal volumes as an acid etching treatment solution, putting the matrix subjected to sand blasting treatment into the acid etching treatment solution for corrosion for 2.0h, cleaning by deionized water, and drying by blowing for the next step. After sand blasting and acid etching treatment, a honeycomb-shaped micropore structure similar to a metal sample tensile fracture is formed on the surface of the substrate.
(5) And (4) carrying out plasma spraying on the matrix subjected to sand blasting and acid etching treatment in the step (4): firstly, adopting a plasma spraying technology, taking hydroxyapatite powder as a raw material, wherein the spraying power is 85W, the feeding speed is 32g/min, the spraying distance is 100mm, and the spraying speed is N2-H2And spraying for 3 times in a spraying environment, and sequentially forming a hydroxyapatite coating 5 with the thickness of 130 mu m on the surface of the coating. Cleaning the substrate coated with hydroxyapatite coating with anhydrous ethanol for 20min, placing in a vacuum chamber, and subjecting to Ar treatment before ion implantation+Sputter cleaning for 10min, and finally using CF4Spraying for 6.5h as ion implantation source to form a layer of coating 4 (metal fluoride) containing fluorine ions with thickness of 400 μm on the surface of the implant.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A3D printed dental implant, comprising: the matrix consists of a base station and a tooth root, wherein the surface of the matrix is provided with a micron-sized hole structure, and the inner surface of the hole structure is of an uneven structure; a hydroxyapatite coating on the tooth root surface and in the pore structure; a fluoride ion-containing coating disposed within the micro-cavities and hydroxyapatite coating; and the external thread is positioned on the surface of the coating containing the fluorine ions, and a transition layer containing the fluorine ions is formed between the coating containing the micro-pores and the hydroxyapatite coating.
2. The 3D printed dental implant of claim 1, wherein the fluoride ion containing coating is a metal fluoride in composition.
3. The 3D printed dental implant of claim 1 or 2, wherein the abutment and the root are each Ti-13Nb-13 Zr.
4. The 3D printed dental implant according to claim 1 or 2, wherein the thickness of the fluoride ion containing coating is in the range of 200-400 μm.
5. The 3D printed dental implant according to claim 1 or 2, wherein the thickness of the hydroxyapatite coating is in the range of 100-130 μm.
6. A method for preparing a 3D printed dental implant, comprising the steps of:
(1) printing a matrix consisting of a base station and a tooth root by adopting a 3D printing technology, and then annealing the matrix to obtain a modified matrix;
(2) carrying out sand blasting treatment on the surface of the modified substrate, then carrying out acid etching treatment, and cleaning and drying after the acid etching treatment to obtain a precursor substrate;
(3) firstly preparing a hydroxyapatite coating on the precursor substrate, and then preparing a fluorine-containing ion coating on the surface of the hydroxyapatite coating to obtain the coating.
7. The method for preparing a 3D-printed dental implant according to claim 6, wherein in step (1), Ti-13Nb-13Zr is used as a printing material, and the 3D-printed parameters are as follows: the laser power is between 300 and 400W, the scanning speed is 100 and 200mm/s, the powder spreading thickness is 30-40 mu m, and the thread pitch of the tooth implant is 750 and 800 mu m; or, in the step (1), the annealing process is: keeping the temperature at 750 ℃ and 800 ℃ for 20-25min, and then cooling to room temperature.
8. The method for preparing a 3D printed dental implant according to claim 6, wherein in the step (2), the sandblasting treatment is performed by using silicon carbide as sandblasting, vertically jetting for 10-30s under the pressure of 0.3-1.5MPa with the jetting distance of 5-12cm, and ultrasonically cleaning the sandblasted substrate with acetone, absolute ethyl alcohol and deionized water in sequence and then drying the substrate; or, in the step (2), the acid etching treatment is: and placing the modified substrate in a mixed solution of a dilute hydrochloric acid solution and a dilute sulfuric acid solution for corrosion for 2-2.5h, cleaning with deionized water, and blow-drying to obtain the precursor substrate.
9. The method for preparing a 3D-printed dental implant according to claim 6, wherein in step (3), the hydroxyapatite coating layer is prepared using a plasma spraying technique, preferably: hydroxyapatite (HA) powder is used as a spraying material, and the spraying power is 80-85W, N2-H2Spraying environment, wherein the feeding speed is 30-35g/min, the spraying distance is 80-100mm, and the spraying is carried out for 2-3 times; or, in the step (3), the fluorine-containing ion coating is prepared by a plasma spraying technology, and preferably: cleaning the substrate with anhydrous alcohol, placing in vacuum chamber, and Ar treating before ion implantation+Sputter cleaning, finally with CF4And (5) spraying for 6-7h as an ion implantation source to obtain the nano-silver/nano-.
10. Use of a 3D printed dental implant according to any of claims 1-5 or a dental implant prepared according to the method of any of claims 6-9 in the medical field.
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