CN111447922A - 用于igf-1r抑制的p-乙氧基核酸 - Google Patents

用于igf-1r抑制的p-乙氧基核酸 Download PDF

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Publication number
CN111447922A
CN111447922A CN201880036079.XA CN201880036079A CN111447922A CN 111447922 A CN111447922 A CN 111447922A CN 201880036079 A CN201880036079 A CN 201880036079A CN 111447922 A CN111447922 A CN 111447922A
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oligonucleotides
cancer
oligonucleotide
population
leu
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CN201880036079.XA
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Chinese (zh)
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阿纳·阿希萨瓦
道格拉斯·克雷格·胡珀
戴维·W·安德鲁斯
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Thomas Jefferson University
Bio Path Holdings Inc
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Thomas Jefferson University
Bio Path Holdings Inc
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/345—Spatial arrangement of the modifications having at least two different backbone modifications

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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201880036079.XA 2017-04-19 2018-04-19 用于igf-1r抑制的p-乙氧基核酸 Pending CN111447922A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762487425P 2017-04-19 2017-04-19
US62/487,425 2017-04-19
PCT/US2018/028308 WO2018195281A1 (en) 2017-04-19 2018-04-19 P-ethoxy nucleic acids for igf-1r inhibition

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Publication Number Publication Date
CN111447922A true CN111447922A (zh) 2020-07-24

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US (2) US20200038429A1 (enExample)
EP (1) EP3628003A4 (enExample)
JP (1) JP2020517645A (enExample)
KR (1) KR20200021453A (enExample)
CN (1) CN111447922A (enExample)
AU (1) AU2018254485B2 (enExample)
CA (1) CA3060090A1 (enExample)
MX (1) MX2019012493A (enExample)
WO (1) WO2018195281A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10206942B2 (en) 2015-04-10 2019-02-19 Thomas Jefferson University Methods and compositions for treating cancers and enhancing therapeutic immunity by selectively reducing immunomodulatory M2 monocytes
KR102755601B1 (ko) 2015-10-14 2025-01-17 바이오-패쓰 홀딩스 인크. 리포좀 제제를 위한 p-에톡시 핵산
US10927379B2 (en) 2016-09-16 2021-02-23 Bio-Path Holdings, Inc. Combination therapy with liposomal antisense oligonucleotides
IL269608B2 (en) 2017-04-19 2024-06-01 Bio Path Holdings Inc Compositions comprising p-ethoxy nucleic acids for stat3 inhibition for use in treating cancer or autoimmune disease
US12234457B2 (en) 2017-04-19 2025-02-25 Bio-Path Holdings, Inc. P-ethoxy nucleic acids for BCL2 inhibition
JP2022512894A (ja) * 2018-11-02 2022-02-07 トーマス・ジェファーソン・ユニバーシティ アンチセンスを使用した乳癌治療用の方法および組成物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015886A (en) * 1993-05-24 2000-01-18 Chemgenes Corporation Oligonucleotide phosphate esters
WO2001060998A2 (en) * 2000-02-18 2001-08-23 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
WO2003070911A2 (en) * 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Inc Rna interference mediated inhibition of type 1 insulin-like growth factor receptor (igf-1r)
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
US20070202157A1 (en) * 1995-08-29 2007-08-30 Gabriel Lopez-Berestein Liposomal Phosphodiester, Phosphorothioate, and p-Ethoxy Oligonucleotides
US20170056430A1 (en) * 2015-04-10 2017-03-02 Thomas Jefferson University Methods and Compositions for Treating Cancers and Enhancing Therapeutic Immunity by Selectively Reducing Immunomodulatory M2 Monocytes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6340674B1 (en) 1993-03-26 2002-01-22 Thomas Jefferson University Method of inhibiting the proliferation and causing the differentiation of cells with IGF-1 receptor antisense oligonucleotides
US9150605B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
US10806095B2 (en) 2014-07-17 2020-10-20 Signify Holding B.V. Horticultural lighting apparatus
KR102755601B1 (ko) 2015-10-14 2025-01-17 바이오-패쓰 홀딩스 인크. 리포좀 제제를 위한 p-에톡시 핵산

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6015886A (en) * 1993-05-24 2000-01-18 Chemgenes Corporation Oligonucleotide phosphate esters
US20070202157A1 (en) * 1995-08-29 2007-08-30 Gabriel Lopez-Berestein Liposomal Phosphodiester, Phosphorothioate, and p-Ethoxy Oligonucleotides
US20030180789A1 (en) * 1998-12-30 2003-09-25 Dale Roderic M.K. Arrays with modified oligonucleotide and polynucleotide compositions
WO2001060998A2 (en) * 2000-02-18 2001-08-23 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
WO2003070911A2 (en) * 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Inc Rna interference mediated inhibition of type 1 insulin-like growth factor receptor (igf-1r)
US20170056430A1 (en) * 2015-04-10 2017-03-02 Thomas Jefferson University Methods and Compositions for Treating Cancers and Enhancing Therapeutic Immunity by Selectively Reducing Immunomodulatory M2 Monocytes

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Y GUTIÉRREZ-PUENTE ET AL: "Safety, pharmacokinetics, and tissue distribution of liposomal P-ethoxy antisense oligonucleotides targeted to Bcl-2", 《JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》 *
YOLANDA GUTIE´RREZ-PUENTE ET AL: "Cellular Pharmacology of P-ethoxy Antisense Oligonucleotides Targeted to Bcl-2 in a Follicular Lymphoma Cell Line", 《LEUKEMIA & LYMPHOMA》 *
潘耀振等: "脂质体介导的IGF-1R反义寡核苷酸对胰腺癌细胞生长的抑制作用", 《中华放射医学与防护杂志》 *
王季堃等: "反义IGF—I寡核苷酸转染抑制人肝癌细胞生长的实验观察", 《中国肿瘤临床》 *

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Publication number Publication date
AU2018254485B2 (en) 2024-07-11
JP2020517645A (ja) 2020-06-18
EP3628003A4 (en) 2021-01-20
WO2018195281A1 (en) 2018-10-25
EP3628003A1 (en) 2020-04-01
AU2018254485A1 (en) 2019-10-31
CA3060090A1 (en) 2018-10-25
MX2019012493A (es) 2020-08-17
US20200038429A1 (en) 2020-02-06
US20220133775A1 (en) 2022-05-05
KR20200021453A (ko) 2020-02-28
US12472199B2 (en) 2025-11-18

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