CN1114394C - Caries-preventive dentifrice composition - Google Patents
Caries-preventive dentifrice composition Download PDFInfo
- Publication number
- CN1114394C CN1114394C CN 97114612 CN97114612A CN1114394C CN 1114394 C CN1114394 C CN 1114394C CN 97114612 CN97114612 CN 97114612 CN 97114612 A CN97114612 A CN 97114612A CN 1114394 C CN1114394 C CN 1114394C
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- CN
- China
- Prior art keywords
- xylitol
- sodium
- dentifrice composition
- caries
- sodium polyacrylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Abstract
A dentifrice composition for prevention of dental caries which shows continuously depressant effect for cariogenic bacteria derived from xylitol and is excellent in preventive effect for dental caries by formulating a specific alkali metal salt of organic acid along with xylitol.
Description
The present invention relates to a kind of dentifrice composition, it can be controlled the antibacterial that produces dental caries effectively and prevent dental caries.
As disclosed among the JP-A106741/1976, the known preparation that wherein is mixed with xylitol can prevent dental caries effectively.The anti-caries effect of xylitol also has report in the literature.The anti-caries effect is brought into play in the growth that it has been generally acknowledged that the antibacterial streptococcus mutant body (S. mutant) of xylitol by suppressing to produce dental caries.
Regrettably, time of existing in the oral cavity of xylitol falls short of.Before xylitol was given full play to the anti-caries effect, it must stop the sufficiently long time in the oral cavity.Therefore, the preparation that wherein is mixed with xylitol usually adopts the form of chewing gum and tablet.The preparation of the type is an acceptable in some country.Yet, forbid in chewing gum and tablet, adding xylitol in Japan, because xylitol does not allow as food additive.
Usually, antibacterial usually is mixed in the antibacterial that produces dental caries in the dentifrice composition in order to control.In this respect, xylitol has been listed in the Japanese pharmacopeia and has been taken as the medicine as safe as a house that is used to infuse.Like this, we can believe that xylitol can sneak in the toothpaste safely.
Yet, so wherein be mixed with xylitol dentifrice composition since short one day of xylitol time of staying in the oral cavity must in the oral cavity, use repeatedly.In real life, for a people, can not repeatedly brush teeth in one day.This does not need to increase the number of times of brushing teeth that exceeds daily habits with regard to wishing development technique to make xylitol performance anti-caries effect.
Therefore, the object of the present invention is to provide a kind of dentifrice composition that contains the anti-caries xylitol, it can bring into play the anti-caries effect of xylitol continuously.
Very unexpected is that we find that the xylitol that has added sodium polyacrylate by use can make xylitol holdup time in the oral cavity prolong.Xylitol can continue to bring into play its inhibitory action to the antibacterial of generation dental caries in the oral cavity like this.By brushing teeth of daily number of times, the number that produces the antibacterial (S. mutant) of dental caries in the oral cavity is just reduced.So just obtain a kind of in fact acceptable dentifrice composition, it contains anticariogenic xylitol as active component.
Be noted that dental field as you know xylitol be a kind of wetting agent and sodium polyacrylate is a kind of binding agent.The inventor unexpectedly finds can reach the remarkable effect that improves the holdup time of xylitol in the oral cavity by being used in combination above-mentioned two kinds of known components first.
Therefore, the invention provides a kind of anti-caries dentifrice composition that contains the xylitol that has added sodium polyacrylate.
Anti-caries dentifrice composition of the present invention is made generally in toothpaste, wet dentifrice and liquid tooth paste.Said composition contains the xylitol that has added sodium polyacrylate.
The amount of blended xylitol is preferably the 1-60% of whole composition weights, more preferably 5-30%.Xylitol is less than 1% can not effectively prevent dental caries, and xylitol then makes the use feeling of toothpaste and taste degenerate more than 60%.
Although xylitol also is used as wetting agent in toothpaste, in dentifrice composition, can also mix another kind of wetting agent.The example of other wetting agent comprises: glycerol, propylene glycol, ethylene glycol, Polyethylene Glycol and 1,3 butylene glycol, independent or two or more mixing are used.They are noted that sugar alcohol such as Sorbitol is unwanted, because can limit the control action of xylitol to the dental caries antibacterial.The amount of blended wetting agent is preferably about 20-80% of whole composition weights (adding the wetting agent of interpolation in xylitol), more preferably 25-60%.Wetting agent is less than 20% will make dentifrice composition hard, and wetting agent then makes the use feeling of toothpaste and taste degenerate more than 80%.
Sodium polyacrylate comprises crosslinked and not crosslinked, and the present invention can use any one.When the polyacrylic acid sodium water solution of 0.5% weight is 100-40 25 ℃ viscosity, 000 centipoise, more preferably 1,000-20,000 centipoise, most preferably 8,000-12 during 000 centipoise, has obtained result preferably.For fixed this aqueous solution of viscosity, crosslinked sodium polyacrylate is better than noncrosslinking sodium polyacrylate, although the bad understanding of reason.
The amount of blended sodium polyacrylate is preferably the 0.01-3% of total composition weight, more preferably 0.1-1%.Sodium polyacrylate is less than 0.01% effect that will not have its additive, dentifrice composition contain surpass 3% sodium polyacrylate then can be too hard.
Usually, sodium polyacrylate is used as binding agent in dentifrice composition.In practice of the present invention, the binding agent a kind of commonly used except that sodium polyacrylate can join in the dentifrice composition in blend.The example of other binding agent comprises the alkali metal salt and the carboxymethyl hydroxyethyl cellulose sodium of cellulose derivative such as carboxymethyl cellulose, methylcellulose, hydroxyethyl-cellulose; The alkali metal alginate are such as sodium alginate; Propylene glycol alginate, carrageenin (carrageenan); Natural gum class such as xanthan gum (xanthane gum), Tragacanth, karaya, Radix Acaciae senegalis and melon ear resin; Synthetic binding agent such as polyvinyl alcohol and polyvinylpyrrolidone; Inorganic binder such as Alusil and Laponite
, independent or two or more mixing are used.Wherein, from the preferred xanthan gum of the viewpoint of compositions storage stability.The amount of blended binding agent preferably is less than about 3% total composition weight (adding the binding agent of interpolation in sodium polyacrylate), more preferably about 0.5-2%.Dentifrice composition contains and surpasses 3% binding agent and will become thickness and be inconvenient to use, and in the storage process of heat, understands too thickness and can not extrude.
In compositions of the present invention, can sneak into other component, for example: pharmaceutical agent, grinding agent, surfactant, sweeting agent, fumet, coloring agent and antiseptic.These components can be used by convention amount.
Useful additive component is described below.The example of grinding agent comprises silica abrasive such as sedimentary Silicon stone, silica gel, aluminosilicate and silicon zirconates and secondary Calcium Phosphate, Dibasic Dihydrate and anhydrous calcium phosphate, calcium pyrophosphate, calcium carbonate, aluminium hydroxide, aluminium oxide, magnesium carbonate, magnesium phosphate, insoluble Polymeric sodium metaphosphate., insoluble potassium metaphosphate, titanium dioxide, zeolite, aluminium silicate, Zirconium orthosilicate. and synthetic resin grinding agent.Blended grinding agent quantitative range can be the 0-60% of total composition weight, preferred 1-50%.
Surfactant comprises: anion, cation and nonionic surfactant, for example: sodium lauryl sulfate, alpha-olefin sodium sulfonate, N-acyl sarcosinates, N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-ethoxy-imidazoles betaine, N-acyl amino esilate, sucrose fatty acid ester, hydramine, polyoxyethylene hardened castor oil, polyglyceryl fatty acid ester, Pluronic
With the polyoxyethylene sorbitan monostearate.The amount ranges of blended surfactant can be the 0-5% of total composition weight, preferred 0.1-3%.
The example of sweeting agent comprises: saccharin sodium, stevioside, stevioside extract (Steviaextract), right-methoxycinnamic aldehyde, new Pericarpium Citri junoris base dihydrochalcone, perillartine.Examples of preservatives is parabenzoic acid ester and sodium benzoate.Useful pharmaceutical agent comprises fluoride such as sodium fluoride, potassium fluoride, ammonium fluoride, stannous fluoride and a fluoro sodium phosphate; Water miscible phosphate cpd is such as ortho-phosphoric potassium and sodium salt; Allantoin chlorine hydroxy Al, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and salt thereof, sodium chloride, tranexamic acid, episilon amino caproic acid, the dl-vitamin E acetate, α-bisabolol, chlorhexidine salt, hexadecylpyridinium chloride, azulene, glycyrrhetinic acid, copper compound such as CHLOROPHYLLINE sodium copper and copper gluconate, aluctyl., strontium chloride, potassium nitrate, berberine, hydroxamic acid and derivant thereof, Sodium triphosphate, glucanase, mutant enzyme, amylase, methoxy-ethylene, maleic anhydride copolymers, polyvinylpyrrolidone, epidihydrocholesterol, benzethonium chloride, dihydrocholesterol, neko, zinc citrate, the soft extract of Rhizoma Ligustici, Cortex Phellodendri (phellodendron) bark extract, the clove tree extract, Herba Rosmarini Officinalis, Radix Scutellariae root and Flos Carthami.The example of fumet such as terpenes are such as 1-menthol, carvone, anethole and limonene and derivant thereof.The example of coloring agent is No. 1 indigo plant, No. 4 Huangs and titanium dioxide.Said components can be used in the effective dose blend.
Dentifrice composition of the present invention can effectively prevent dental caries, wherein it make xylitol bring into play continuously its antibacterial that suppress to produce dental caries effect and thereby when using with the daily number of times of brushing teeth, reduced the number of this antibacterial in the oral cavity.
Embodiment:
Embodiments of the invention prove but do not limit the present invention.All percent is % weight.Used sodium polyacrylate is crosslinked sodium polyacrylate among the embodiment, and the solution viscosity of its 0.5wt% is 10,000 centipoises at 25 ℃.
Embodiment 1 and comparative example 1-3
The dentifrice composition of prescription is tested shown in the his-and-hers watches 1.The people of 40 health is divided into equal four groups.They (brush tooth every day three times) and used this toothpaste three months on the basis of daily habits.Calculate the number that uses the S. mutant bacteria in this toothpaste front and back saliva.The results are shown in Table 2.
Table 1
| E1 | CE1 | CE2 | CE3 | |
| The multiviscosisty Silicon stone | 5 | 5 | 5 | 5 |
| Silicon stone | 20 | 20 | 20 | 20 |
| Propylene glycol | 3 | 3 | 3 | 3 |
| 85% glycerol | 25 | 40 | 25 | 25 |
| Xylitol | 10 | - | 10 | 10 |
| Xanthan gum | 0.5 | 0.5 | 0.5 | - |
| Sodium polyacrylate | 0.5 | 0.5 | - | - |
| Sodium carboxymethyl cellulose | - | - | 0.5 | - |
| Sodium alginate | - | - | - | 0.3 |
| Carrageenin | - | - | - | 0.6 |
| Sodium lauryl sulfate | 1 | 1 | 1 | 1 |
| Right-hydroxy benzoate | 0.1 | 0.1 | 0.1 | 0.1 |
| Titanium dioxide | 0.3 | 0.3 | 0.3 | 0.3 |
| Fumet | 1 | 1 | 1 | 1 |
| Water | Surplus | Surplus | Surplus | Surplus |
| Amount to | 100.0 | 100.0 | 100.0 | 100.0 |
Table 2
| S. mutant bacteria number/ml saliva (CFU * 10 3) | ||||
| On average | Intermediate value | Scope | ||
| Before the use | Embodiment 1 | 517.8 | 50.6 | 3.1-8700 |
| Comparative example 1 | 425.1 | 43.2 | 9.5-6600 | |
| Comparative example 2 | 398.1 | 48.2 | 10.7-4100 | |
| Comparative example 3 | 453.4 | 39.5 | 5.8-11200 | |
| After the use | Embodiment 1 | 102.4 | 18.2 | N.D.-2200 |
| Comparative example 1 | 441.1 | 54.5 | 2.4-5200 | |
| Comparative example 2 | 378.4 | 39.7 | 3.8-4700 | |
| Comparative example 3 | 308.3 | 41.0 | 5.1-7300 | |
By table 2 as seen, the anti-caries dentifrice composition (embodiment 1) in the scope of the invention can be controlled the S. mutant bacteria effectively.
Embodiment 2 (ointment type toothpaste): 0.2% pair-hydroxy benzoate of multiviscosisty silica 5.0% silica, 10.0% xylitol 10.0% propane diols, 3.0%85% glycerine 20.0% Sodium Polyacrylate, 0.5% xanthans 0.5% NaLS, 1.0% sodium fluoride, 0.1% titanium dioxide, 0.4% magnesium sulfate, 0.7% fumet, 1.0% water surplus
Amount to 100.0%
1.0% pair-hydroxy benzoate of embodiment 3 Calcium Phosphate, Dibasic Dihydrates, 35.0% xylitol 25.0% propane diols, 3.0% Sodium Polyacrylate 1.5% xanthans, 0.2% NaLS, 0.1% saccharin sodium, 0.1% fumet, 1.0% water surplus
Amount to 100.0%
0.1% pair-hydroxy benzoate of embodiment 4 multiviscosisty silicas, 3.0% silica 20.0% xylitol, 50.0% PEG400 5.0% Sodium Polyacrylate, 1.0% xanthans 0.5% NaLS, 1.3% sodium fluoride, 0.1% saccharin sodium, 0.1% sodium sulphate, 0.7% fumet, 1.0% water surplus
Amount to 100.0%
0.38% pair-hydroxy benzoate of embodiment 5 multiviscosisty silica 2.0% aluminium hydroxide, 40.0% xylitol 20.0% propane diols, 5.0%85% glycerine 10.0% Sodium Polyacrylate, 2.0% xanthans 0.3% NaLS, 1.2% 1 fluoro sodium phosphates, 0.2% saccharin sodium, 0.2% fumet, 1.0% water surplus
Amount to 100.0%
0.76% pair-hydroxy benzoate of embodiment 6 multiviscosisty silicas, 3.0% Calcium Phosphate, Dibasic Dihydrate 30.0% xylitol, 5.0% propane diols 3.0%85% glycerine, 20.0% Sodium Polyacrylate 1.3% xanthans, 0.2% sodium carboxymethylcellulose 0.5% NaLS, 1.2% 1 fluoro sodium phosphate, 0.1% saccharin sodium, 0.05% fumet, 1.2% water surplus
Amount to 100.0%
0.2% pair-hydroxy benzoate of embodiment 7 multiviscosisty silica 3.0% silica, 15.0% xylitol 10.0% propane diols, 3.0%85% glycerine 12.0% Sodium Polyacrylate, 1.2% xanthans 0.8% NaLS, 1.0% sodium fluorides, 0.1% saccharin sodium, 0.1% titanium dioxide, 0.2% fumet, 1.0% water surplus
Amount to 100.0%
0.76% pair-hydroxy benzoate of embodiment 8 multiviscosisty silica 2.0% aluminium hydroxide, 30.0% xylitol 20.0% propane diols, 5.0% Sodium Polyacrylate 1.2% xanthans, 0.5% sodium carboxymethylcellulose 0.8% NaLS, 0.8% 1 fluoro sodium phosphates, 0.1% saccharin sodium, 0.1% fumet, 1.2% water surplus
Amount to 100.0%
0.5% pair-hydroxy benzoate of embodiment 9 multiviscosisty silica 3.0% silica, 20.0% xylitol 30.0% PEG400,5.0% Sodium Polyacrylate 1.1% xanthans, 0.5% NaLSs, 0.1% saccharin sodium, 0.2% fumet, 0.8% water surplus
Amount to 100.0%
Although narrated some embodiment preferred, can also do many improvement and adjustment according to above-mentioned guidance.Therefore be appreciated that in appended claim scope, except such as the specific descriptions, the present invention can also implement.
Claims (3)
1. an anticariogenic dentifrice composition wherein contains the xylitol that has added sodium polyacrylate.
2. the dentifrice composition of claim 1, wherein the viscosity in aqueous solution of 0.5% weight of sodium polyacrylate is 100-40 at 25 ℃, 000 centipoise.
3. claim 1 or 2 dentifrice composition, wherein sodium polyacrylate is a cross-linking type.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP204229/96 | 1996-07-15 | ||
| JP20422996 | 1996-07-15 | ||
| JP204229/1996 | 1996-07-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1171931A CN1171931A (en) | 1998-02-04 |
| CN1114394C true CN1114394C (en) | 2003-07-16 |
Family
ID=16486989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97114612 Expired - Lifetime CN1114394C (en) | 1996-07-15 | 1997-07-14 | Caries-preventive dentifrice composition |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1114394C (en) |
| ID (1) | ID17509A (en) |
| MY (1) | MY125752A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7074391B1 (en) * | 2000-10-16 | 2006-07-11 | Biocosmetics, S.L. | Use of olive oil in the preparation of a product for oral hygiene for eliminating or reducing bacterial plaque and/or bacteria in the mouth |
-
1997
- 1997-07-03 MY MYPI9703010 patent/MY125752A/en unknown
- 1997-07-04 ID IDP972338A patent/ID17509A/en unknown
- 1997-07-14 CN CN 97114612 patent/CN1114394C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1171931A (en) | 1998-02-04 |
| MY125752A (en) | 2006-08-30 |
| ID17509A (en) | 1998-01-08 |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20030716 |