CN111419314A - Medical blood vessel connector - Google Patents
Medical blood vessel connector Download PDFInfo
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- CN111419314A CN111419314A CN202010164025.0A CN202010164025A CN111419314A CN 111419314 A CN111419314 A CN 111419314A CN 202010164025 A CN202010164025 A CN 202010164025A CN 111419314 A CN111419314 A CN 111419314A
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- pipe section
- blood vessel
- parts
- inner support
- reaction kettle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D4/00—Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
- C09D4/06—Organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups C09D159/00 - C09D187/00
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/08—Anti-corrosive paints
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/18—Fireproof paints including high temperature resistant paints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B2017/1107—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis for blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
- A61B2017/1132—End-to-end connections
Abstract
The invention discloses a medical blood vessel connector, which comprises an inner support and an outer support; the inner support is an elastic hollow tubular structure, can be compressed and elongated to move in a blood vessel and can be expanded into a tube body in the blood vessel; the outer support is used for being sleeved outside a blood vessel, and the inner support is tightly attached to the inner wall of the outer support after being unfolded so as to clamp the blood vessel between the inner support and the outer support; the outer support comprises a rigid pipe section I, a flexible pipe section and a rigid pipe section II, the flexible pipe section is of a flexible seamless pipe body structure, and the rigid pipe section I and the rigid pipe section II are of rigid seamless pipe body structures and are coaxially connected through the flexible pipe section; the outer surface of the inner support is provided with an anti-aging protective layer, and the anti-aging protective layer is formed by coating anti-aging paint. The invention enables a user to synchronously control the inner bracket and the outer bracket of the device so as to conveniently connect blood vessels, simplify the operation process and shorten the operation time; meanwhile, the inner support has better ageing resistance and corrosion resistance, and the service life of the inner support is effectively prolonged.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a medical blood vessel connector.
Background
When the aorta and peripheral blood vessel surgery is performed, blood vessels are usually cut off and then connected, the traditional method is a needle and thread suture anastomosis method, but the operation is complicated and time-consuming, the injury of the blood vessel intima is large, and the suture line often causes the deposition of blood platelets, so that serious complications such as thrombosis and the like are caused. In order to replace needle and thread sewing, a clamping type connection method exists in the field.
Patent CN 108903984 a discloses a clamping type medical blood vessel connector, which includes an inner stent and an outer stent, wherein the inner stent is an elastic hollow tubular structure, the inner stent can be compressed and elongated to move in a blood vessel and can be expanded into a tube body in the blood vessel, the outer stent is used for being sleeved outside the blood vessel, and the inner stent is tightly attached to the inner wall of the outer stent after being expanded to clamp the blood vessel between the inner stent and the outer stent.
However, the clamping type medical blood vessel connector has inconvenience in use in practical application, and prolongs the operation time; the reason is that, because the outer stent is of a non-deformable rigid seamless tube structure (in order to prevent bleeding after blood vessel connection), in the absence of a special operating tool, the inner stent and the outer stent need to be respectively acted by applying force through vascular clamps or hands of a doctor to act (i.e. move or deform), cannot be operated at the same time, but are limited by the structure of the tubular part, and in order to eliminate interference between the two stents, the stress sites of the two stents need to be frequently changed, so that the operation time is prolonged, and the labor consumption is increased. In addition, the inner support as a key part has relatively poor ageing resistance and corrosion resistance, the surface of the inner support is easy to rust, and the service life of the inner support is shortened
Therefore, the medical blood vessel connector needs to be improved, so that the inner stent and the outer stent can be simultaneously controlled, the blood vessel can be conveniently connected, the operation process is simplified, and the operation time is shortened; meanwhile, the inner support has better ageing resistance and corrosion resistance, and the service life of the inner support is effectively prolonged.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a medical blood vessel connector, which enables a user to synchronously control an inner bracket and an outer bracket of the medical blood vessel connector so as to conveniently connect the blood vessel, simplify the operation process and shorten the operation time; meanwhile, the inner support has better ageing resistance and corrosion resistance, and the service life of the inner support is effectively prolonged.
In order to achieve the purpose, the invention provides the following technical scheme:
a medical blood vessel connector comprising an inner stent and an outer stent; the inner support is of an elastic hollow tubular structure, can be compressed and elongated to move in a blood vessel and can be expanded into a tube body in the blood vessel; the outer support is used for being sleeved outside a blood vessel, and the inner support is tightly attached to the inner wall of the outer support after being unfolded so as to clamp the blood vessel between the inner support and the outer support;
the outer support comprises a rigid pipe section I, a flexible pipe section and a rigid pipe section II, the flexible pipe section is of a flexible seamless pipe body structure, and the rigid pipe section I and the rigid pipe section II are of rigid seamless pipe body structures and are coaxially connected through the flexible pipe section;
the inner support is made of alloy materials with shape memory effect, and the elastic hollow tubular structure is a silk-screen-shaped woven tube body;
the outer surface of the inner support is provided with an anti-aging protective layer, and the anti-aging protective layer is formed by coating anti-aging paint;
the anti-aging coating is composed of the following raw material components in parts by weight: 85 parts of modified water-based epoxy resin emulsion, 9 parts of zirconium phosphate, 9 parts of ultramarine, 5 parts of polyhexamethylene guanidine, 4.3 parts of barium petroleum sulfonate, 4.6 parts of lanoline magnesium soap, 4.0 parts of dodecenylsuccinic acid, 5.3 parts of glass flake, 11 parts of vinyl bis stearamide, 3.2 parts of glycerin monostearate, 2.0 parts of emulsifier, 2.0 parts of dispersant, 1.6 parts of film-forming assistant, 1.5 parts of flatting agent, 1.5 parts of defoaming agent, 1.6 parts of surfactant and 23 parts of deionized water;
the preparation method of the modified waterborne epoxy resin emulsion comprises the following steps:
a. transferring the aqueous epoxy resin emulsion into a reaction kettle, adding a proper amount of glyceryl monostearate and deionized water into the reaction kettle, setting the temperature in the reaction kettle to be 75 ℃, stirring for 5min at a speed of 420r/min by a stirrer, premixing toluene and epoxy resin, adding gamma-methacryloxypropyltrimethylsilane into the reaction kettle at the temperature, mixing and stirring for 10min at a speed of 200r/min, setting the temperature in the reaction kettle to be 95 ℃ after mixing, reacting for 10h at the temperature, and marking the obtained mixture as a mixed component in the reaction kettle after the reaction is finished;
b. cooling the mixed components in the reaction kettle to room temperature under natural conditions, and then adjusting the pH of the mixed components to 8.0 by using an ammonia water solution with the concentration of 6.0-8.0%, and marking the obtained mixture as a mixed solution;
c. heating the temperature of the mixed liquid in the reaction kettle to 80 ℃, adding 2-hydroxy-4-n-octoxy benzophenone, dibutyltin dilaurate and an initiator solution into the reaction kettle, and carrying out heat preservation reaction for 6 hours at the temperature of 80 ℃; and naturally cooling to room temperature, filtering and discharging to obtain the modified waterborne epoxy resin emulsion.
By adopting the technical scheme, the invention has the following beneficial technical effects:
the medical blood vessel connector of the invention is formed by connecting the rigid pipe section I, the flexible pipe section and the rigid pipe section II which are connected in sequence through the structural improvement of the outer bracket, when in use, the inner bracket can be firstly placed in the outer bracket, the flexible pipe section and the inner support can be simultaneously compressed by applying radial acting force to the flexible pipe section, and the pipe diameters of the rigid pipe section I and the rigid pipe section II are kept unchanged, a gap for the broken blood vessel to extend into is temporarily formed between the inner support and the rigid pipe section I and the rigid pipe section II, when the blood vessel is stretched into a proper position, the acting force on the flexible pipe section is released, the flexible pipe section and the inner support are gradually restored to the original state, the inner support gradually props up the blood vessel in the restoration process and enables the blood vessel to cling to the inner wall of the outer support, under the external pressure of the inner stent and the blocking action of the outer stent, the blood vessel is clamped between the inner stent and the outer stent; compared with the prior art, the improvement of the structure enables the inner support and the outer support to be controlled simultaneously, the blood vessel can be conveniently connected, the operation process is simplified, the operation time is shortened, and the structure has higher practical value. Meanwhile, the anti-aging protective layer is arranged on the outer surface of the inner support, so that the anti-aging performance and the corrosion resistance of the inner support are improved, and the service life of the key component of the inner support is prolonged.
The invention is further configured to: the flexible pipe section is made of silica gel, and two ends of the flexible pipe section are connected with the rigid pipe section I and the rigid pipe section II respectively in a hot melting connection mode.
The invention is further configured to: the length of the flexible pipe section is 8.0mm-15.0 mm.
The invention is further configured to: the emulsifier is monoglyceride fatty acid glyceride; the dispersant is glyceryl tristearate; the film-forming auxiliary agent is propylene glycol methyl ether acetate; the leveling agent is polymethyl alkyl siloxane; the defoaming agent is an organic silicon defoaming agent BYK-018; the surfactant is fatty acid sorbitan.
The invention is further configured to: the inner support is provided with a developing indicating mark.
The invention is further configured to: the surface of the outer support is coated with a film coating layer, and the part of the film coating layer corresponding to the flexible pipe section is a corrugated film section which can adapt to the deformation of the flexible pipe section.
The invention is further configured to: the film coating layer is made of nylon, terylene or polytetrafluoroethylene.
Drawings
FIG. 1 is a structural cross-sectional view of the present invention;
FIG. 2 is an enlarged view of FIG. 1 at A;
fig. 3 is a front view of the inner frame structure of the present invention.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in fig. 1 to 3: the embodiment provides a medical blood vessel connector, which comprises an inner support 1 and an outer support 2; the inner support 1 is an elastic hollow tubular structure, and the inner support 1 can be compressed and elongated to move in a blood vessel and can be expanded into a tube body in the blood vessel; the outer stent 2 is used for being sleeved outside a blood vessel, and the inner stent 1 is tightly attached to the inner wall of the outer stent 2 after being unfolded so as to clamp the blood vessel between the inner stent 1 and the outer stent 2.
The medical blood vessel connector provided by the embodiment is improved on the basis of the clamping type medical blood vessel connector disclosed in the patent CN 108903984 a, so that the principle and part of the structure of the medical blood vessel connector are consistent with those of the above-mentioned devices, for example, the structure of the inner stent 1 can be the same as that of the above-mentioned devices, that is, the inner stent 1 is made of an alloy material with a shape memory effect, the elastic hollow tubular structure is a silk-mesh woven tube, the inner stent 1 can be provided with a developing indicator 1a, the obtained technical effects are also described in the above-mentioned patent specification, and the description of the same parts is omitted.
The medical blood vessel connector of the embodiment is mainly improved on the structure of the external stent 2, that is, the external stent 2 includes a rigid tube section i 21, a flexible tube section 22 and a rigid tube section ii 23, the flexible tube section 22 is a flexible seamless tube structure, and the rigid tube section i 21 and the rigid tube section ii 23 are both rigid seamless tube structures and are coaxially connected through the flexible tube section 22. The rigid pipe section I21 and the rigid pipe section II 23 can be made of medical alloy materials and can be circular pipe structures with the same length; the flexible pipe section 22 can be made of silica gel, at the moment, two ends of the flexible pipe section 22 are respectively connected with the rigid pipe section I21 and the rigid pipe section II 23 in a hot melting connection mode, and no gap is formed at the connection part; the length of the flexible tube segment 22 may be 8.0mm-15.0mm to accommodate manipulation using vascular clamps or manual manipulation; the flexible tube 22 of this construction is axially elongated by a length and the opposite sides are also radially inwardly displaced, i.e. from a circular to an oval shape, and returns to a circular shape when in a free state.
The medical blood vessel connector of the embodiment is formed by connecting an outer support 2 through structural improvement on the outer support 2, so that the outer support 2 is formed by connecting a rigid pipe section I21, a flexible pipe section 22 and a rigid pipe section II 23 which are connected in sequence, when the medical blood vessel connector is used, an inner support 1 can be placed in the outer support 2, the flexible pipe section 22 and the inner support 1 can be simultaneously compressed by applying radial acting force to the flexible pipe section 22, a gap for a broken blood vessel to stretch into is temporarily formed between the inner support 1 and the rigid pipe section I21 and the rigid pipe section II 23 because the pipe diameters of the rigid pipe section I21 and the rigid pipe section II 23 are kept unchanged, after a blood vessel stretches into a proper position, the acting force to the flexible pipe section 22 and the inner support 1 are gradually restored, the inner support 1 gradually props up the blood vessel and enables the blood vessel to be tightly attached to the inner wall of the outer support 2 in the restoration process, under the blocking action of the outer support 1 and, the blood vessel is clamped between the inner stent 1 and the outer stent 2; compared with the prior art, the improvement of the structure enables the inner support 1 and the outer support 2 to be controlled simultaneously, the blood vessel can be conveniently connected, the operation process is simplified, the operation time is shortened, and the structure has higher practical value.
The surface (including outer surface and internal surface) of outer support 2 is wrapped with tectorial membrane layer 3, the position that flexible pipe section 22 is corresponded to in tectorial membrane layer 3 is the ripple membrane section 3a that can adapt to flexible pipe section 22 deformation. The film coating layer 3 can prevent the outer bracket 2 from directly contacting with the blood vessel, thereby reducing the abrasion to the blood vessel; the corrugated film section 3a on the film coating layer 3 can adapt to the deformation of the flexible pipe section 22 and can stretch together with the flexible pipe section 22, namely, the corrugated film section 3a can stretch when the flexible pipe section 22 is stretched, and the corrugated film section 3a also compresses together when the flexible pipe section 22 is compressed; the material of the coating layer 3 can be the same as that of the existing artificial blood vessel, for example, the coating layer is made of nylon, terylene or polytetrafluoroethylene, so as to avoid the repulsion with the blood vessel.
The outer surface of the inner bracket 1 may be provided with an anti-aging protective layer (not shown), which is formed by coating anti-aging paint.
The anti-aging coating is composed of the following raw material components in parts by weight: 85 parts of modified water-based epoxy resin emulsion, 9 parts of zirconium phosphate, 9 parts of ultramarine, 5 parts of polyhexamethylene guanidine, 4.3 parts of barium petroleum sulfonate, 4.6 parts of lanoline magnesium soap, 4.0 parts of dodecenylsuccinic acid, 5.3 parts of glass flake, 11 parts of vinyl bis stearamide, 3.2 parts of glycerin monostearate, 2.0 parts of emulsifier, 2.0 parts of dispersant, 1.6 parts of film-forming assistant, 1.5 parts of flatting agent, 1.5 parts of defoaming agent, 1.6 parts of surfactant and 23 parts of deionized water.
The preparation method of the modified waterborne epoxy resin emulsion comprises the following steps:
a. transferring the aqueous epoxy resin emulsion into a reaction kettle, adding a proper amount of glyceryl monostearate and deionized water into the reaction kettle, setting the temperature in the reaction kettle to be 75 ℃, stirring for 5min at a speed of 420r/min by a stirrer, premixing toluene and epoxy resin, adding gamma-methacryloxypropyltrimethylsilane into the reaction kettle at the temperature, mixing and stirring for 10min at a speed of 200r/min, setting the temperature in the reaction kettle to be 95 ℃ after mixing, reacting for 10h at the temperature, and marking the obtained mixture as a mixed component in the reaction kettle after the reaction is finished;
b. cooling the mixed components in the reaction kettle to room temperature under natural conditions, and then adjusting the pH of the mixed components to 8.0 by using an ammonia water solution with the concentration of 6.0-8.0%, and marking the obtained mixture as a mixed solution;
c. heating the temperature of the mixed liquid in the reaction kettle to 80 ℃, adding 2-hydroxy-4-n-octoxy benzophenone, dibutyltin dilaurate and an initiator solution into the reaction kettle, and carrying out heat preservation reaction for 6 hours at the temperature of 80 ℃; and naturally cooling to room temperature, filtering and discharging to obtain the modified waterborne epoxy resin emulsion.
In the embodiment, the emulsifier is monoglyceride fatty acid glyceride, the dispersant is glyceryl tristearate, the film-forming aid is propylene glycol methyl ether acetate, the leveling agent is polymethyl alkyl siloxane, the defoaming agent is an organic silicon defoaming agent BYK-018, and the surfactant is sorbitan fatty acid.
The preparation method of the anti-aging coating comprises the following steps:
s1, accurately weighing the raw materials, respectively placing the solid raw materials into a grinding machine for grinding, and then sieving the solid raw materials by a 200-mesh sieve to obtain fine powder of the solid raw materials; storing and standby;
s2, adding the modified waterborne epoxy resin emulsion into a reaction kettle, setting the temperature of the reaction kettle to 80 ℃, and then adding a surfactant, a dispersant and an emulsifier into the reaction kettle; after uniformly mixing and stirring, adding the fine powder of each solid raw material obtained in the step S1 into a reaction kettle while stirring, mixing and stirring at the speed of 360r/min for 10min, then adding all the rest raw materials into the reaction kettle, and uniformly mixing and stirring at the speed of 420r/min, wherein the mixture obtained in the reaction kettle is marked as a mixed component;
s3, measuring the viscosity value of the mixed component obtained in the step S2 by a 4-cup coating measurement method, ensuring that the viscosity of the mixed component is within the range of 140S, and marking the obtained mixed component as a crude coating product;
s4, filtering the coating crude product obtained in the step S3 by using a fine mesh filter screen, then placing the product into a reaction kettle, setting the temperature in the reaction kettle to be 80 ℃, and then carrying out ultrasonic vibration treatment by using an ultrasonic vibration rod at the frequency of 35KHz until bubbles in the coating crude product are sufficiently expelled out;
and S5, detecting the physical and chemical properties of the coating in the S4, and packaging after the coating is detected to be qualified to obtain the finished product of the anti-aging coating for the medical instrument.
After the finished product of the anti-aging coating is obtained, an anti-aging protective layer can be formed on the inner bracket 1 through the existing coating process, the thickness of the anti-aging protective layer can be 100-120 μm, and the anti-aging performance and the corrosion resistance of the inner bracket 1 are improved, which is caused by the following reasons:
firstly, the anti-aging coating of the embodiment takes the modified waterborne epoxy resin emulsion as a raw material for preparing the coating, and the waterborne epoxy resin emulsion is chemically modified by gamma-methacryloxypropyltrimethylsilane and 2-hydroxy-4-n-octoxybenzophenone; under the action of gamma-methacryloxypropyltrimethylsilane, the epoxy resin and the 2-hydroxy-4-n-octoxybenzophenone are indirectly connected by chemical bonds, so that the modified waterborne epoxy resin emulsion has good ultraviolet resistance, and the aging resistance of the coating is improved. Moreover, the glass flakes and the 2-hydroxy-4-n-octoxy benzophenone are mutually cooperated, so that the thermal expansion coefficient and the bonding thermal stress of the coating prepared by the invention are relatively small, and the phenomenon of 'peeling' of the coating caused by heating is obviously improved.
Secondly, the anti-aging coating of this embodiment selects vinyl bis stearamide, ultramarine blue and zirconium phosphate as raw materials for preparing the coating, wherein the vinyl bis stearamide has a strong affinity for the ultramarine blue and the zirconium phosphate, and polar groups in the molecules of the vinyl bis stearamide firmly adsorb the ultramarine blue and the zirconium phosphate, so that the polar groups are firmly adhered to the surfaces of the ultramarine blue and the zirconium phosphate. And the carbon-hydrogen bond can directionally extend into the external medium to extend, so that the interfacial tension between the surfaces of the ultramarine blue and the zirconium phosphate and the external medium is reduced, the wettability of the ultramarine blue and the zirconium phosphate is obviously improved, the ultramarine blue and the zirconium phosphate can be more uniformly mixed in the coating, and the performance of the prepared coating is ensured. Furthermore, the combination of ultramarine and zirconium phosphate improves the corrosion resistance of the coating obviously.
Thirdly, the anti-aging coating of the embodiment adopts barium petroleum sulfonate, lanolin magnesium soap, dodecenylsuccinic acid and polyhexamethylene guanidine, and the anti-aging coating can remarkably improve the anti-rust performance and the wear resistance of the prepared coating and correspondingly prolong the service life of the coating by matching the barium petroleum sulfonate, the lanolin magnesium soap, the dodecenylsuccinic acid and the polyhexamethylene guanidine according to a certain proportion.
To confirm the excellent performance of the anti-aging coating, the anti-aging coating (comparative example) produced by Shanghai paint company and prepared in this example were tested, and the data are shown in the following table:
(Note: 1, abrasion resistance of the paint prepared in the examples of the present invention was measured in accordance with GB 1768. 2, and heat resistance of the paint prepared in the examples of the present invention was measured in accordance with Q/Ez 159-2003.)
As can be seen from the data in the table above, the anti-aging coating prepared by the embodiment has better anti-aging performance, corrosion resistance, high temperature resistance, wear resistance and adhesion performance than the comparative examples. The coating prepared by the embodiment has better integral performance than a proportion, and can effectively improve the ageing resistance and the corrosion resistance of the inner support 1.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (6)
1. A medical blood vessel connector comprising an inner stent and an outer stent; the inner support is of an elastic hollow tubular structure, can be compressed and elongated to move in a blood vessel and can be expanded into a tube body in the blood vessel; the outer support is used for being sleeved outside a blood vessel, and the inner support is tightly attached to the inner wall of the outer support after being unfolded so as to clamp the blood vessel between the inner support and the outer support; the method is characterized in that:
the outer support comprises a rigid pipe section I, a flexible pipe section and a rigid pipe section II, the flexible pipe section is of a flexible seamless pipe body structure, and the rigid pipe section I and the rigid pipe section II are of rigid seamless pipe body structures and are coaxially connected through the flexible pipe section;
the inner support is made of alloy materials with shape memory effect, and the elastic hollow tubular structure is a silk-screen-shaped woven tube body;
the outer surface of the inner support is provided with an anti-aging protective layer, and the anti-aging protective layer is formed by coating anti-aging paint;
the anti-aging coating is composed of the following raw material components in parts by weight: 85 parts of modified water-based epoxy resin emulsion, 9 parts of zirconium phosphate, 9 parts of ultramarine, 5 parts of polyhexamethylene guanidine, 4.3 parts of barium petroleum sulfonate, 4.6 parts of lanoline magnesium soap, 4.0 parts of dodecenylsuccinic acid, 5.3 parts of glass flake, 11 parts of vinyl bis stearamide, 3.2 parts of glycerin monostearate, 2.0 parts of emulsifier, 2.0 parts of dispersant, 1.6 parts of film-forming assistant, 1.5 parts of flatting agent, 1.5 parts of defoaming agent, 1.6 parts of surfactant and 23 parts of deionized water;
the preparation method of the modified waterborne epoxy resin emulsion comprises the following steps:
a. transferring the aqueous epoxy resin emulsion into a reaction kettle, adding a proper amount of glyceryl monostearate and deionized water into the reaction kettle, setting the temperature in the reaction kettle to be 75 ℃, stirring for 5min at a speed of 420r/min by a stirrer, premixing toluene and epoxy resin, adding gamma-methacryloxypropyltrimethylsilane into the reaction kettle at the temperature, mixing and stirring for 10min at a speed of 200r/min, setting the temperature in the reaction kettle to be 95 ℃ after mixing, reacting for 10h at the temperature, and marking the obtained mixture as a mixed component in the reaction kettle after the reaction is finished;
b. cooling the mixed components in the reaction kettle to room temperature under natural conditions, and then adjusting the pH of the mixed components to 8.0 by using an ammonia water solution with the concentration of 6.0-8.0%, and marking the obtained mixture as a mixed solution;
c. heating the temperature of the mixed liquid in the reaction kettle to 80 ℃, adding 2-hydroxy-4-n-octoxy benzophenone, dibutyltin dilaurate and an initiator solution into the reaction kettle, and carrying out heat preservation reaction for 6 hours at the temperature of 80 ℃; and naturally cooling to room temperature, filtering and discharging to obtain the modified waterborne epoxy resin emulsion.
2. The medical blood vessel connector according to claim 1, wherein: the flexible pipe section is made of silica gel, and two ends of the flexible pipe section are connected with the rigid pipe section I and the rigid pipe section II respectively in a hot melting connection mode.
3. A medical blood vessel connector according to claim 2, wherein: the length of the flexible pipe section is 8.0mm-15.0 mm.
4. A medical blood vessel connector according to any of claims 1 to 3, wherein: the emulsifier is monoglyceride fatty acid glyceride; the dispersant is glyceryl tristearate; the film-forming auxiliary agent is propylene glycol methyl ether acetate; the leveling agent is polymethyl alkyl siloxane; the defoaming agent is an organic silicon defoaming agent BYK-018; the surfactant is fatty acid sorbitan.
5. The medical blood vessel connector according to any of claims 1 to 4, wherein: the surface of the outer support is coated with a film coating layer, and the part of the film coating layer corresponding to the flexible pipe section is a corrugated film section which can adapt to the deformation of the flexible pipe section.
6. The medical blood vessel connector according to claim 5, wherein: the film coating layer is made of nylon, terylene or polytetrafluoroethylene.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010164025.0A CN111419314A (en) | 2020-03-11 | 2020-03-11 | Medical blood vessel connector |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010164025.0A CN111419314A (en) | 2020-03-11 | 2020-03-11 | Medical blood vessel connector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111419314A true CN111419314A (en) | 2020-07-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010164025.0A Withdrawn CN111419314A (en) | 2020-03-11 | 2020-03-11 | Medical blood vessel connector |
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| US3648295A (en) * | 1970-10-12 | 1972-03-14 | James R Palma | Guide for growing blood vessels or the like |
| US4728328A (en) * | 1984-10-19 | 1988-03-01 | Research Corporation | Cuffed tubular organic prostheses |
| DE10015145A1 (en) * | 2000-03-29 | 2001-10-11 | Fraunhofer Ges Forschung | Connector for vessel anastomosis comprises mesh metal inner sleeve covered by biocompatible biodegradable polymer outer sleeve to clamp vessel ends after laser shrinkage with retained flow section. |
| US20070250082A1 (en) * | 2004-07-22 | 2007-10-25 | Kansoul Hassan A | Anastomosis Device and Method |
| CN101883539A (en) * | 2007-10-11 | 2010-11-10 | 米卢克斯控股股份有限公司 | Implantable tissue connector |
| WO2015192022A1 (en) * | 2014-06-13 | 2015-12-17 | The Regents Of The University Of California | Sutureless anastomosis device |
| CN105939676A (en) * | 2013-12-06 | 2016-09-14 | W·L·戈尔及同仁股份有限公司 | Anastomotic connectors |
| CN106726001A (en) * | 2017-01-06 | 2017-05-31 | 北京华脉泰科医疗器械有限公司 | Exempt from suture stent-graft and its conveying device, coincide clasp |
| CN108903984A (en) * | 2018-07-20 | 2018-11-30 | 中国医学科学院阜外医院 | Clipping anastomotic fitting |
| CN109480944A (en) * | 2019-01-11 | 2019-03-19 | 青岛大学附属医院 | A kind of novel vascular surgery vascular anastomosis device |
| CN109880452A (en) * | 2019-01-22 | 2019-06-14 | 广州市加杰机械设备有限公司 | A kind of body of a motor car aging resistant coating and preparation method thereof |
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2020
- 2020-03-11 CN CN202010164025.0A patent/CN111419314A/en not_active Withdrawn
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3648295A (en) * | 1970-10-12 | 1972-03-14 | James R Palma | Guide for growing blood vessels or the like |
| US4728328A (en) * | 1984-10-19 | 1988-03-01 | Research Corporation | Cuffed tubular organic prostheses |
| DE10015145A1 (en) * | 2000-03-29 | 2001-10-11 | Fraunhofer Ges Forschung | Connector for vessel anastomosis comprises mesh metal inner sleeve covered by biocompatible biodegradable polymer outer sleeve to clamp vessel ends after laser shrinkage with retained flow section. |
| US20070250082A1 (en) * | 2004-07-22 | 2007-10-25 | Kansoul Hassan A | Anastomosis Device and Method |
| CN101883539A (en) * | 2007-10-11 | 2010-11-10 | 米卢克斯控股股份有限公司 | Implantable tissue connector |
| CN105939676A (en) * | 2013-12-06 | 2016-09-14 | W·L·戈尔及同仁股份有限公司 | Anastomotic connectors |
| WO2015192022A1 (en) * | 2014-06-13 | 2015-12-17 | The Regents Of The University Of California | Sutureless anastomosis device |
| CN106726001A (en) * | 2017-01-06 | 2017-05-31 | 北京华脉泰科医疗器械有限公司 | Exempt from suture stent-graft and its conveying device, coincide clasp |
| CN108903984A (en) * | 2018-07-20 | 2018-11-30 | 中国医学科学院阜外医院 | Clipping anastomotic fitting |
| CN109480944A (en) * | 2019-01-11 | 2019-03-19 | 青岛大学附属医院 | A kind of novel vascular surgery vascular anastomosis device |
| CN109880452A (en) * | 2019-01-22 | 2019-06-14 | 广州市加杰机械设备有限公司 | A kind of body of a motor car aging resistant coating and preparation method thereof |
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