CN111419155A

CN111419155A - Cooling medium spraying device and tissue detection device in minimally invasive surgery

Info

Publication number: CN111419155A
Application number: CN202010304286.8A
Authority: CN
Inventors: 胡三元
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-04-17
Filing date: 2020-04-17
Publication date: 2020-07-17
Anticipated expiration: 2040-04-17
Also published as: CN111419155B

Abstract

The application discloses cooling medium sprinkler in minimal access surgery includes: the insertion assembly is used for spraying a cooling medium to a tissue to be detected in a body of a surgical object and comprises a first insertion pipe, a spray head and a first bending part arranged between the head part of the first insertion pipe and the spray head; a conduit for conveying a cooling medium, at least a region of the conduit extending within the first insertion tube, the first bend, and the spray head; and a first handle portion that can adjust a bent state of the first bending portion by operating the first handle portion, thereby adjusting a posture of the head. The application also discloses a tissue detection device in minimally invasive surgery, which comprises an endoscope, a display unit and the spraying device. The detection device in the application can rapidly detect tissues in the operation through the temperature change rate under the operation condition so as to realize the identification of tumor tissues, and has the advantages of being minimally invasive, capable of realizing real-time dynamic detection, continuous detection and the like.

Description

Cooling medium spraying device and tissue detection device in minimally invasive surgery

Technical Field

The application belongs to the technical field of medical equipment, and particularly relates to a cooling medium spraying device and a tissue detection device in minimally invasive surgery.

Background

Under the action of various carcinogenic factors, a certain cell of a local tissue loses normal regulation and control on the growth of the local tissue at the gene level, so that the tumor is an abnormal lesion formed by clonal abnormal hyperplasia. The existing detection methods for tumors mainly comprise various types such as laboratory examination, radiology examination, radionuclide examination, ultrasonic examination and the like, and the existing detection methods for various tumors have a commonality, namely, the pathological analysis of the tumors needs two paths of sampling analysis and image analysis, and have the defects of long detection period, incapability of final diagnosis, need of subsequent observation and the like. Particularly, in order to realize the sampling and analyzing process carried out in a clinical practice, when a patient is clinically subjected to tumor biopsy sampling, the tumor biopsy sampling is realized through a scalpel, the wound is large, double physical and psychological wounds are brought to the patient, in the sampling process, the tissue to be detected is not easily separated and taken out from the sampling injector after entering the sampling injector, and before the sampling injector is transferred to a detection room, part of the sampled tissue is exposed, so that cross infection is possibly caused, and the accuracy of a detection result is influenced.

With the development and progress of gene technology, a detection method for detecting cancer and analyzing genetic composition of tumor through simple blood detection (liquid biopsy technology) is currently available, and since the liquid biopsy technology has the advantages of non-invasiveness, convenience, tolerance and the like, unlike the conventional tumor biopsy, the liquid biopsy only requires a blood sample of a patient, reduces the amount of exposure of the patient to harmful radiation during the processes of investigation, treatment and follow-up, and is appreciated by the patient and a doctor. However, the existing liquid biopsy technology has a great limitation in the detection of early tumors because the number and concentration of Circulating Tumor Cells (CTCs) or circulating tumor dna (ctdna) in blood of a patient at the early stage of the tumor are low and often lower than the detection limit, and in addition, the liquid biopsy technology mainly relies on the separation of cancer cells in blood, so that the detection cost is high, and for the patient needing continuous detection to realize follow-up treatment, the high-cost medical burden can make the patient and the family thereof prohibitive, and also influence the wide application of the liquid biopsy technology.

It will thus be seen that the prior art is susceptible to further improvement and enhancement.

Disclosure of Invention

The application provides a cooling medium spraying device and a tissue detection device in minimally invasive surgery to realize the rapid detection of tumors, the operation is simple and easy, and the waiting time of a patient can be greatly shortened.

The technical scheme adopted by the application is as follows:

a cooling medium spraying device for minimally invasive surgery, comprising: the device comprises an insertion assembly, a heating assembly and a cooling assembly, wherein the insertion assembly is used for being inserted into a surgical object and spraying a cooling medium to a tissue to be detected in the surgical object, and comprises a first insertion pipe, a spray head and a first bending part arranged between the head of the first insertion pipe and the spray head; a conduit for conveying a cooling medium, at least a region of the conduit extending within the first insertion tube, first bend, and spray head; and a first holding part provided at a tail portion of the first insertion tube, wherein a moving distance of the insertion unit is adjustable by operating the first holding part, and a bent state of the first bending part is adjustable by operating the first holding part, thereby adjusting a posture of the head.

The cooling medium spraying device also comprises the following additional technical characteristics:

the first bending part comprises a plurality of joints which are sequentially hinged, each joint is hollow inside, and the joints are mutually communicated to form a channel for the guide pipe to pass through.

The first bending portion further includes hinges for realizing the hinge joint of two adjacent joints, and the axial directions of the two adjacent hinges are perpendicular to each other, so that the first bending portion can deflect in a first direction and a second direction perpendicular to each other.

The spraying device further comprises a traction unit, the traction unit comprises two groups of traction assemblies, each traction assembly comprises two traction ropes, the two traction ropes belonging to the same traction assembly are oppositely arranged, and the deflection angle of the first bending part is limited in the first direction and the second direction; one end of each traction rope is locked on the first handheld part, and the other end of each traction rope passes through each joint and is fixed on the spray head or the joint positioned at the most front end.

The cooling medium is cooling liquid or cooling gas.

An intraoperative tissue detection device for minimally invasive surgery, comprising: the cooling medium spraying device in the minimally invasive surgery as described above; the endoscope and the cooling medium spraying device are arranged in a separated mode, the endoscope comprises a collecting part which can stretch into the body of an operation object, the collecting part is provided with an image pickup element and a temperature detection element, the image pickup element is used for collecting tissue images, and the temperature detection element is used for detecting the temperature of the tissue in the body of the operation object; and the display unit is used for displaying the tissue image and can represent the characteristic quantity of the temperature rise rate of the tissue to be detected.

The detection device also comprises the following additional technical features:

the detection device further comprises a comparison unit, wherein the comparison unit comprises: the storage module is internally pre-stored with a characteristic quantity A capable of representing the temperature rise rate of a normal tissue; the calculation module is used for receiving the temperature signal detected by the temperature detection element and calculating the temperature rise rate of the tissue to be detected to obtain a characteristic quantity B for representing the temperature rise rate of the tissue to be detected; the comparison unit is used for comparing the characteristic quantity A with the characteristic quantity B and transmitting a comparison result to the display unit for displaying.

The detection device further comprises: a cooling medium reservoir storing a cooling medium for supplying the cooling medium to the spray device; and a control unit for controlling the temperature of the cooling medium and the spraying amount, spraying duration and spraying interval time of the spraying device.

The endoscope also comprises a second handheld part and a second insertion tube which is arranged between the collecting part and the second handheld part in an extending mode, a second bending part is arranged between the second insertion tube and the collecting part, and the bending state of the second bending part can be adjusted by operating the second handheld part so as to achieve posture adjustment of the collecting part.

At least a partial region of the first insertion tube is flexible and/or at least a partial region of the second insertion tube is flexible.

Due to the adoption of the technical scheme, the beneficial effects obtained by the application are as follows:

1. this application adopts coolant spraying device sprays coolant to waiting to examine the tissue, for detection device detects, discerns the temperature rate of rising back of tissue and provides technical support, through the operation first handheld portion can be adjusted the bending state of first flexion to realize the adjustment of shower nozzle gesture, thereby can first intubate keeps under the unchangeable condition of position appearance, realizes the adjustment of shower nozzle spray range, has enlarged the spray range of shower nozzle, has reduced the interference and the damage to patient's internal tissue. In this application coolant sprinkler is particularly useful for among the minimal access surgery process, but the state real-time display of shower nozzle in display element, the doctor can be according to display element's the posture of adjusting the shower nozzle in real time, and the influence of reducible subjective factor promotes the accuracy of spraying. In addition, this application passes through cooling medium sprinkler sprays cooling medium to examining the tissue, can control the volume of spraying, spray rate and the even degree of spraying to can realize the control to the impact force of examining the tissue of spouting, avoid handling the harm of examining the tissue because of the too big cause of impact force, thereby reduced the subjective factor because of operating doctor by a wide margin, and spray volume and spray rate and carry out manual control according to personal experience and give the adverse effect that the operation of spraying brought to spraying process through the visual observation.

2. As a preferred embodiment of the present application, the first bending portion includes a plurality of sequentially articulated joints, each joint is hollow inside, and each joint is communicated with each other to form a channel for the catheter to pass through, so that on one hand, the catheter can be protected, and on the other hand, the catheter can be prevented from rubbing against a protective sleeve arranged on the periphery of the first bending portion to cause resistance to the deflection of the first bending portion, and the catheter is configured to pass through the inner side of the first bending portion, so that the deflection flexibility of the first bending portion can be ensured, and the operation and control of a doctor can be facilitated; furthermore, the catheter is arranged along the inner extension of the first bending part, so that the inner space of the joint can be fully utilized, the radial size of the first bending part is reduced, the radial size of the insertion assembly is reduced, the size of an opening in a human body is reduced, the wound of a patient is convenient to heal, and the experience of the patient is pleased.

3. As a preferred embodiment of this application for connect the axis direction mutually perpendicular of two adjacent first articulated elements of two adjacent joints, thereby can make first flexion can deflect in mutually perpendicular's first direction and second direction, has improved the degree of freedom of first flexion has enlarged the spraying scope of shower nozzle, has promoted the accuracy of detection, has reduced the scope and the range of coolant sprinkler bulk movement, has reduced interference and the damage that causes human tissue because of the apparatus removes by a wide margin.

4. As a preferred embodiment of the present application, the posture adjustment of the first bending portion is completed by the cooperation of two sets of traction assemblies, and the inner side of each joint is provided with a traction rope limiting portion for limiting one set of the traction assemblies, so that on one hand, the flexibility of joint movement can be increased, and on the other hand, the traction rope limiting portion is arranged on the inner side of the joint, so that the space inside the joint can be fully utilized, thereby reducing the radial size of the first bending portion, contributing to the miniaturization of the insertion assembly, reducing the wound area, and reducing the interference and damage to the tissues of the patient. Furthermore, the spacing portion of haulage rope to the joint is inside to be protruded, and adjacent two the spacing portion cooperation of haulage rope of joint can be right the pipe is followed the radial direction of first flexion forms spacingly, and the spacing portion of haulage rope has played the effect of spacing pipe simultaneously promptly, has avoided rocking of the inside pipe of joint, helps promoting the assembly efficiency of product, improves the yield of product.

5. The detection device can rapidly detect tissues in an operation through the temperature change rate under the operation condition so as to realize the identification of tumor tissues, can cut off the identified tumor tissues under the operation condition, eliminates the hidden danger of pathological changes under the condition of not increasing the recovery period of a patient, has the advantages of being minimally invasive, capable of realizing real-time dynamic detection, continuous detection and the like, and has irreplaceable advantages in the aspects of early diagnosis, personalized treatment, prognosis prediction and the like of tumors. And it is easy to operate, has reduced the requirement to the doctor, and compares in prior art's tumour detection technique, utilizes the detection device in this application to detect tumour tissue, and the cost is lower, easily is accepted by the patient, helps its wide application.

6. In this application the endoscope with coolant sprinkler components of a whole that can function independently sets up, not only can realize respective function respectively among the operation process, can mutually support in order to realize waiting to examine the temperature detection and the monitoring of organizing moreover to realize tumour discernment. In addition, the endoscope and the cooling medium spraying device are arranged in a split mode, so that not only are respective assembling convenient, but also the radial size of the respective insertion tube and the bending part is reduced, the size of the punch hole in the patient is reduced, and recovery of the patient is facilitated.

7. As an preferred embodiment of this application, detection device is still including comparing the unit, compare the unit and can compare the characteristic quantity A of the temperature rise rate of the normal tissue of representation and the characteristic quantity B of waiting to examine tissue temperature rise rate of representation, and transmit the result of comparison extremely display element shows, has made things convenient for in the operation process, and the doctor can pass through display element observes directly perceivedly to wait to detect the difference that the tissue is compared in normal tissue to make quick judgement, avoided subjective judgement, help objectification, standardization and the intellectuality of tumour detection.

8. As a preferred embodiment of the present application, at least a partial region of the first insertion tube is flexible, and/or at least a partial region of the second insertion tube is flexible, and the flexible region of the first insertion tube is connected to the first bending portion, and/or the flexible region of the second insertion tube is connected to the second bending portion, so that on one hand, the physician can move the insertion assembly and the endoscope conveniently, and on the other hand, the interference and damage caused by the movement to the tissues around the tissue to be examined in the patient body can be reduced.

Drawings

The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the application and together with the description serve to explain the application and not to limit the application. In the drawings:

fig. 1 is a schematic view of an application of the detection apparatus of the present application.

FIG. 2 is a comparison graph of the temperature-time variation curve of the tissue to be examined and the temperature-time variation curve of the normal tissue in the same coordinate system.

FIG. 3 is a schematic view of an embodiment of a cooling medium spray apparatus of the present application with the protective sleeve removed.

Fig. 4 is a partial schematic structural view of an embodiment of a cooling medium spraying apparatus according to the present application.

FIG. 5 is a partial schematic view of an embodiment of a first bend described herein.

FIG. 6 is a schematic view of an embodiment of an endoscope as described herein.

FIG. 7 is a side view of an embodiment of an endoscope as described herein.

Wherein:

1, tissue to be detected;

2 cooling medium spraying device, 21 first insertion pipe, 22 first bending part, 221 joint, 2211 joint body, 2212 hinge convex edge, 2213 hinge concave part, 2214 pivot shaft, 2215 traction rope limiting part, 23 spray head, 24 steel wire, 25 conduit and 26 first handheld part;

3 a display unit;

4 temperature-time curve;

5 endoscope, 51 acquisition unit, 52 imaging device, 53 temperature detection device, 54 illumination device, 55 signal line, 56 second insertion tube, 57 second bending unit, 58 second hand-held unit.

Detailed Description

In order to more clearly explain the overall concept of the present application, the following detailed description is given by way of example in conjunction with the accompanying drawings.

In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application, however, the present application may be practiced in other ways than those described herein, and therefore the scope of the present application is not limited by the specific embodiments disclosed below.

In addition, in the description of the present application, it is to be understood that the terms "top," "bottom," "inner," "outer," "axial," "radial," "circumferential," and the like are used in the positional or orientational relationship shown in the drawings for the purpose of convenience and simplicity of description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the present invention.

In this application, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can include, for example, fixed connections, removable connections, or integral parts; the connection can be mechanical connection, electrical connection or communication; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

In this application, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through intervening media. In the description herein, reference to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

As shown in fig. 3 to 5, a cooling medium spraying apparatus for minimally invasive surgery includes: the device comprises an insertion assembly, a heating assembly and a cooling assembly, wherein the insertion assembly is used for being inserted into a surgical object and spraying a cooling medium to a tissue to be detected in the surgical object, and comprises a first insertion pipe, a spray head and a first bending part arranged between the head of the first insertion pipe and the spray head; a conduit for conveying a cooling medium, at least a region of the conduit extending within the first insertion tube, first bend, and spray head; and a first holding part provided at a tail portion of the first insertion tube, wherein a moving distance of the insertion unit is adjustable by operating the first holding part, and a bent state of the first bending part is adjustable by operating the first holding part, thereby adjusting a posture of the head.

This application passes through cooling medium sprinkler sprays cooling medium to waiting to examine the tissue, in order to measure the temperature rise rate creation condition of waiting to examine the tissue, the real-time position and the gesture of shower nozzle can show following display element, and the doctor can pass through the real-time status of shower nozzle is observed to the display element is audio-visual, and passes through first handheld portion adjustment the gesture of shower nozzle to the realization is to the adjustment of spraying the position, thereby reducible subjective factor's influence promotes the accuracy of spraying, and establishes the basis for the accuracy of waiting to examine tissue temperature rise rate and detect.

As a preferred embodiment of the present application, the first bending portion 22 includes a plurality of first joints 221 sequentially articulated and a first hinge for realizing articulation of two adjacent first joints 221, and the first hinge is configured to enable the first bending portion 22 to deflect in a first direction and a second direction, which are perpendicular to each other. Specifically, the axial directions of two adjacent first hinges are perpendicular to each other, and the "two adjacent first hinges" herein refers to a hinge capable of deflecting the first bent portion 22 in the first direction and a hinge capable of deflecting the first bent portion 22 in the second direction. In a specific example, the first direction is a left-right direction, the second direction is an up-down direction, and two degrees of freedom of pitching and left-right deflection of the first bending portion 22 can be controlled by operating the first handheld portion 26, so that the moving range of the spray head 23 is expanded under the condition that the position of the cooling medium spraying device 2 is fixed, the detection range is enlarged, the detection accuracy is improved, the range and the amplitude of the overall movement of the cooling medium spraying device 2 are reduced, and the interference and damage to human tissues caused by the movement of instruments are greatly reduced.

A protective sleeve is arranged on the outer side of the first bending part 22 to realize the isolation of the first bending part 22 from the outside and avoid interference on the tissue of the patient in the process of the movement of the first joint 221. Preferably, the outer diameter of the protective sleeve is substantially equal to the outer diameter of the first insertion tube 21. In a preferred embodiment of the present application, each of the first joints 221 is hollow, and each of the first joints 221 is communicated with each other to form a passage for the conduit 25 to pass through. In the present embodiment, the fitting of each first joint 221 provides conditions for the conduit 25 to extend inside the first bending portion 22: in one aspect, the conduit 25 may be shielded; on the other hand, the catheter 25 can be prevented from rubbing against the protective sleeve arranged on the periphery of the first bending portion 22 to cause resistance to the deflection of the first bending portion 22, and the catheter 25 can be configured to pass through the inner side of the first bending portion 22, so that the flexibility of the deflection of the first bending portion 22 can be ensured, and the operation control of a doctor can be facilitated; furthermore, the conduit 25 extends along the inside of the first bending portion 22, so that the inner space of the first joint 221 can be fully utilized, the radial dimension of the first bending portion 22 is reduced, the reduction of the overall radial dimension of the cooling medium spraying device 2 is facilitated, the size of an opening in a human body is reduced, the healing of a wound of a patient is facilitated, and the experience of the patient is pleased.

In the following, a preferred embodiment is taken as an example to further describe the structure of the first bending portion 22 in the present application, and for convenience of description, the orientation of the spray head 23 along the axial direction of the first insertion tube 21 is defined as front, and the orientation of the first holding portion 26 is defined as rear:

as shown in fig. 3 to 5, the first joint 221 is a thin-walled ring structure, and the first joint 221 includes a joint body 2211, two opposite positions of the front end of the joint body 2211 are respectively provided with a hinge convex edge 2212, the hinge convex edge 2212 extends forwards and protrudes, two opposite positions of the rear end of the joint body 2211 are respectively provided with a hinge concave portion 2213, and the relative orientation of the two hinge concave portions 2213 is perpendicular to the relative orientation of the two hinge convex edges 2212, for example, the two hinge convex edges 2212 are arranged oppositely along the first direction, the two hinge concave portions 2213 are arranged oppositely along the second direction, wherein the hinge convex edge 2212 of one first joint 221 (for convenience of description, it is defined as a first joint) is matched with the hinge concave portion 2213 of the joint 221 (for convenience of description, it is defined as a second joint), and the articulation of the first joint and the second joint is realized through a pivot axis 2214, the hinge recess 2213 of the first joint is engaged with a hinge protrusion 2212 of a joint 221 (defined as a third joint for convenience of description) located at the rear thereof, and the first joint and the third joint are hinged by a pivot shaft 2214, and so on, so that the sequential hinging of the first joints 221 is realized, and the control of the deflection angle of the first bending portion 22 in the first direction and the second direction is realized.

Further, as a preferred example of the present embodiment, after the hinge convex edge 2212 of the first joint 221 is matched with the hinge concave portion 2213 of the joint 221 located in front of the hinge convex edge 2212, the outer diameter of the matched position of the two (i.e. the sum of the thickness of the joint 221 where the hinge concave portion 2213 is located and the outer diameter of the thickness of the joint 221 where the hinge convex edge 2212 is located) is substantially equal to the outer diameter of the joint body 2211 of each first joint 221, so that after the assembly is completed, the distance between each point of the outer surface of the first bending portion 22 and the inner wall of the protection sleeve is substantially equal, thereby avoiding the unequal interference caused by the unequal distance between the outer surface and the inner wall of the protection sleeve during the deflection of the first bending portion 22 and further influencing the control of the posture of the first bending portion 22.

In the present application, the cooling medium spraying device 2 further comprises a first pulling unit, the first pulling unit comprises two sets of first pulling assemblies, each of the first pulling assemblies comprises two first pulling ropes, and the two pulling ropes belonging to the same first pulling assembly are oppositely arranged to define a deflection angle of the first bending portion 22 in the first direction and the second direction; one end of each of the first pull strings is locked to the first handle 26, and the other end thereof passes through each of the first joints 221 and is fixed to the head 23 or the first joint 221 located at the forefront, and the bent state of the first bending portion 22 in the first direction and the second direction can be adjusted by operating the first handle 26, so that the posture of the head 23 can be adjusted. Preferably, the first pulling rope is a steel wire 24, in order to conveniently control the deflection angle of the first bending portion 22 in the first direction and the second direction, two steel wires 24 of one group of the first pulling assembly are oppositely arranged along the first direction, and two steel wires 24 of the other group of the first pulling assembly are oppositely arranged along the second direction, during the operation, the two steel wires 24 in opposite positions are regulated in a loosening and tightening manner, so that the first bending portion 22 can be deflected towards the tensioned side, the posture of the first bending portion 22 is adjusted, and the posture of the nozzle 23 is adjusted.

As a preferred embodiment of the present application, as shown in fig. 4 and 5, a traction rope limiting portion 2215 for limiting the first traction assembly is further disposed inside each of the first joints 221, and after the first joints 221 are assembled, the traction rope limiting portions 2215 of all the first joints 221 cooperate together to limit the steel wire 24 at the first bending portion 22. Furthermore, the inner side of one of the first joints 221 is provided with a traction rope limiting portion 2215 for limiting one group of the first traction assemblies, so as to further save the space inside the first joint 221, because each of the first joints 221 is sequentially hinged, and when being assembled, two adjacent first joints 221 have a difference of 90 ° (the hinged convex edge 2212 of one of the first joints 221 can be located on the same straight line with the hinged convex edge 2212 of the other adjacent first joint 221 after being rotated by 90 °), so that the requirement for limiting the steel wire 24 can be met only by arranging two opposite traction rope limiting portions 2215 in one first joint 221, for example, two traction rope limiting portions 2215 are arranged at opposite positions of the first joint along the first direction, and the second joint in front of the first joint needs to be rotated by 90 °, the two traction rope limiting portions 2215 on the second joint are changed to be on two opposite positions in the second direction, the three joints behind the first joint need to rotate 90 degrees relative to the first joint in the assembling position, namely the third joint is consistent with the second joint, the two traction rope limiting portions 2215 on the third joint are on two opposite positions in the second direction, and so on, the four steel wires 24 are limited inside the first joint 221.

In this embodiment, the traction rope limiting portion 2215 is disposed inside the first joint 221, so that the flexibility of the first joint 221 can be increased, and on the other hand, the traction rope limiting portion 2215 is disposed inside the first joint 221, so that the space inside the first joint 221 can be fully utilized, and thus the radial size of the first bending portion 22 is reduced, the cooling medium spraying device 2 is facilitated to be miniaturized, the wound area is reduced, and the interference and damage to the tissues of the patient are reduced. Preferably, the outer profile of the leash-limiting portion 2215 is curved to reduce the frictional damage of the leash-limiting portion 2215 to the catheter 25 during deflection of each of the first joints 221.

Furthermore, the cooling medium spraying device 2 has a plurality of conduits 25, the plurality of conduits 25 extending within the first insertion tube 21, the first bending portion 22 and the spray head 23, and the spray head 23 is provided with a plurality of liquid outlets in correspondence therewith. Preferably, the hauling cable limiting portions 2215 protrude towards the inside of the first joints 221, and the hauling cable limiting portions 2215 of two adjacent first joints 221 are matched to limit the guide pipe 25 along the radial direction of the first bending portion 22, that is, the hauling cable limiting portions 2215 simultaneously play a role of limiting the guide pipe 25, so that the disordered arrangement of the guide pipe 25 inside the first joints 221 is avoided, the routing is facilitated, the assembly efficiency of products is improved, and the yield of the products is improved.

The application also discloses a tissue detection device in minimal access surgery, includes: the cooling medium spraying device 2 in the minimally invasive surgery as described above; an endoscope 5, wherein the endoscope 5 is provided separately from the cooling medium spraying device 2, the endoscope 5 includes a collecting part 51 which can be inserted into the body of the operation object, the collecting part 51 is provided with an image pickup element 52 and a temperature detection element 53, the image pickup element 52 is used for collecting the tissue image, and the temperature detection element 53 is used for detecting the temperature of the tissue in the body of the operation object; and the display unit 3 is used for displaying the tissue image and can represent the characteristic quantity of the temperature rise rate of the tissue to be detected.

When the tissue cancerates, the phenomena of blood vessel proliferation and distortion occur, blood is a heat carrier, the blood vessel proliferation is caused, the perfusion amount of the tissue blood is increased, and the temperature of the part of the tissue is increased. This application is in the operation art, with the help of cooling medium sprinkler 2 is to examining the tissue 1 spraying cooling medium of examining, through temperature detecting element 53 detects the temperature of examining tissue 1, waits to examine the temperature rise rate of examining tissue 1 and the temperature rise rate of normal tissue (the tissue that does not take place canceration) through comparing to judge the possibility of examining tissue 1 canceration. Compared with the traditional technical scheme of determining tumor tissues by surgical biopsy or needle biopsy, the tissue 1 to be detected does not need to be taken out, the possibility of cross infection is reduced, the pain of a patient is reduced in the detection process, and in addition, compared with the technical scheme of waiting for a biopsy result to judge the canceration possibility, the probability of canceration of the tissue can be judged more quickly, the waiting time of the patient is greatly shortened, and the psychological burden of the patient is relieved.

The detection device in this application is as the auxiliary device in the art, can discern the canceration tissue in the operation (like in the laparoscopic surgery art) to excise under the operation condition, from the time cycle that patient's whole operation and postoperative are resumeed, neither can increase patient's recovered phase, also can eliminate pathological change hidden danger in step, help promoting patient's experience. The application can also utilize the detection device to treat that examine tissue 1 carries out many times cooling medium's spraying in certain time interval to treat examining tissue 1 and carry out many times temperature measurement, and calculate and obtain the multiunit and wait the temperature rise rate of examining tissue 1, have the wicresoft, can realize advantages such as real-time dynamic detection and continuous detection, help promoting the accuracy of testing result, have irreplaceable advantage in the aspects such as early diagnosis, individualized treatment, the prediction prognosis of tumour. Moreover, whole easy operation has reduced doctor's the operation degree of difficulty, in addition, compare in traditional tumour detection mode and emerging liquid biopsy technique, this application passes through detection device realizes the detection of tumour, and the cost is lower, is accepted by the patient easily, helps this detection device and detection mode's popularization on a large scale.

In this application endoscope 5 with 2 components of a whole that can function independently settings of cooling medium sprinkler not only can realize respective function respectively in the operation process, can mutually support in order to realize waiting to examine the temperature detection and the monitoring of organizing 1 moreover, finally realizes tumour discernment. In addition, the endoscope 5 and the cooling medium spraying device 2 are arranged separately, so that not only are the respective assembling convenient, but also the radial sizes of the respective insertion pipes and bending parts are reduced, the size of the punch hole on the patient is reduced, and the recovery of the patient is facilitated.

As a preferred embodiment of the present application, the front end of the collecting portion 51 is made of tempered glass with good light transmittance, so that the image pickup element and the following infrared sensor collect an image of a tissue, and the definition of the collected image is improved. Further, the housing of the collecting unit 51 is made of a polymer material with good biocompatibility, so as to hold and fix the imaging element, the temperature detecting element, and the illumination element described below, which are provided in the collecting unit 51.

The present application is not particularly limited to the expression form of the feature quantity, and any one of the following embodiments may be adopted:

example 1, the characteristic quantity is an image for characterizing the temperature of the tissue 1 to be examined as a function of time after being sprayed with the cooling medium, for example, as shown in fig. 1 and 2, which give a temperature-time curve of the characteristic quantity as a temperature rise rate for characterizing the tissue 1 to be examined. Wherein, the horizontal axis is time, the vertical axis is temperature, the curve 1 is a graph of the temperature of the abnormal tissue changing with time, and the

curves

2 and 3 are graphs of the temperature of the normal tissue changing with time respectively.

In example 2, the characteristic amount is a time taken for the tissue 1 to be examined to rise to a fixed temperature after being sprayed with the cooling medium, and the fixed temperature is not particularly limited in this example, and preferably, the fixed temperature is 36 to 37 ℃.

Example 3, the characteristic quantity is the temperature of the tissue 1 to be examined detected at a certain time node (e.g. 15 minutes) after the tissue 1 to be examined is sprayed with the cooling medium.

Example 4, the characteristic quantity is a value for characterizing a specific temperature rise rate of the tissue 1 to be examined after being sprayed with the cooling medium, such as 1K/min.

Of course, the expression of the characteristic quantities described in the present application is not limited to the above-mentioned exemplary embodiments, but it is also possible to use other parameters or expressions which can be used for characterizing the rate of temperature rise of the tissue 1 to be examined.

The type of the cooling medium is not particularly limited in this application. In a specific embodiment, the cooling medium is a cooling liquid, such as water or the like. In another specific embodiment, the cooling medium is a cooling gas, such as nitrogen, oxygen, or the like.

As a preferred embodiment of the present application, the detection apparatus further includes a comparison unit, and the comparison unit includes: the storage module is internally pre-stored with a characteristic quantity A capable of representing the temperature rise rate of a normal tissue; the calculation module is used for receiving the temperature signal detected by the temperature detection element and calculating the temperature rise rate of the tissue 1 to be detected to obtain a characteristic quantity B for representing the temperature rise rate of the tissue 1 to be detected; the comparison unit is used for comparing the characteristic quantity A with the characteristic quantity B and transmitting a comparison result to the display unit 3 for displaying. The normal tissue refers to a tissue which is not cancerated, and the characteristic quantity A is a characteristic quantity which is stored in the storage module in advance. This embodiment through with the comparison result transmit to display element 3 shows, has made things convenient for in the operation process, the doctor can pass through display element 3 observes the difference of waiting to detect tissue 1 and comparing in normal tissue more directly perceivedly to make quick judgement, help tumour detection's objectification, standardization and intellectuality. In addition, in this application endoscope 5 to waiting to examine the collection of tissue 1 image, the detection of temperature, and display element 3 can go on in step to the real-time demonstration of characteristic quantity A and characteristic quantity B to realized dynamic real-time supervision and detection, promoted the accuracy of detected data.

The characteristic quantity B may adopt any one of the expression forms in the four embodiments, and the characteristic quantity a may also adopt an expression form corresponding to the characteristic quantity B, for example, the characteristic quantity B adopts a temperature-time change curve graph 4 for characterizing the temperature rise rate of the tissue 1 to be detected, and the characteristic quantity a adopts a temperature-time change curve graph 4 for characterizing the temperature rise rate of the normal tissue.

The form of the alignment is not specifically limited in the present application: for example, when the characteristic quantity a and the characteristic quantity B both represent the temperature rise rate of the tissue in the form of the temperature-time change graph 4, the comparison may be a comparison of the slope of the two curves, and when the absolute value of the difference between the slope of the curve corresponding to the characteristic quantity B and the slope of the curve corresponding to the characteristic quantity a exceeds the threshold stored in the comparison unit, a prompt of tissue abnormality is issued; for another example, when both the characteristic quantity a and the characteristic quantity B represent the temperature rise rate of the tissue in the form of the temperature-time change curve graph 4, as shown in fig. 2, the two curve graphs may be placed in the same coordinate axis for comparison, the comparison is a closed area formed by matching the two curve graphs, and when the closed area exceeds the threshold S1 stored in the comparison unit, a tissue abnormality prompt is issued; for another example, when the characteristic quantity B is a specific temperature rise rate value for representing the tissue 1 to be detected after being sprayed with the cooling medium, and the characteristic quantity a is a specific temperature rise rate value for representing the normal tissue after being sprayed with the cooling medium, the comparison is a comparison of the two temperature rise rate values, and when an absolute value of the two temperature rise rate values exceeds a threshold value stored in the comparison unit, a prompt of tissue abnormality is given. Of course, other alignment formats may be used to provide guidance for the physician's operation.

The endoscope 5 in the present application further includes an illuminating element 54, the illuminating element 54 is disposed on the collecting portion 51, and preferably, the illuminating element 54 is disposed in a plurality of positions around the front end of the collecting portion 51, as shown in fig. 7, which shows a specific example in which the image pickup element 52 and the temperature detecting element 53 are wrapped between the two illuminating elements 54 to facilitate the collection of image data of the tissue, but the arrangement of the image pickup element 52, the temperature detecting element 53, and the illuminating element 54 in the collecting portion 51 is not limited to the structure shown in the drawing, and other arrangement types may be adopted. The illumination element is connected with the cold light source through the optical fiber so as to transmit illumination in the cold light source to the operation part during the operation, thereby facilitating the acquisition of tissue images. In addition, the outer contour of the capturing part 51 is not limited to the shape similar to the ellipse shown in fig. 7, but may be other types such as a circle, etc.

The endoscope assembly further includes signal lines 55 electrically connected to the image pickup element and the temperature detection element, respectively. As a preferred embodiment of the present application, the temperature detecting element 53 is an infrared sensor, the infrared sensor can be used for collecting the temperature data of the tissue and also can collect the infrared image of the tissue 1 to be detected, and the collected infrared image can be transmitted to the display unit 3 through the signal line 55 for displaying for the reference of the doctor. Fig. 1 shows an example in which the display unit 3 displays a tissue image, and a temperature-time change curve graph 4 of the tissue 1 to be examined and a normal tissue, but the content displayed by the display unit 3 is not limited to this, and it may also display information such as an infrared image of the tissue 1 to be examined.

The detection apparatus in the present application further includes: a cooling medium reservoir storing a cooling medium for supplying the cooling medium to the spray device; and a control unit for controlling the temperature of the cooling medium and the spraying amount, spraying duration and spraying interval time of the spraying device. Through carrying out interval, spraying many times to waiting to examine tissue 1, can carry out the many times collection of data, promote the accuracy of testing result.

The endoscope in the present application further includes a second holding portion 58, and a second insertion tube 56 extending between the collecting portion 51 and the second holding portion 58, a second bending portion 57 is provided between the second insertion tube 56 and the collecting portion 51, and the bending state of the second bending portion 57 can be adjusted by operating the second holding portion 58, so that the posture of the collecting portion 51 can be adjusted.

Specifically, the second bending portion 57 includes a plurality of second joints hinged in sequence, each of the second joints is hollow inside, and the second joints are communicated with each other to form a passage for the signal line 55 and the optical fiber to pass through. As a preferred embodiment of the present application, the structure of the second joint is the same as or similar to the structure of the first joint 221, and the connection manner of two adjacent second joints also adopts the connection manner of two adjacent first joints 221, which is not described herein again. Furthermore, the endoscope 5 further comprises a second traction unit, which comprises two sets of second traction assemblies, each of which comprises two second traction ropes, the two second traction ropes belonging to the same second traction assembly being arranged oppositely to define a deflection angle of the second bending portion at two opposite positions; one end of each second traction rope is locked to the second handheld portion 58, and the other end of each second traction rope passes through each second joint and is fixed to the collecting portion 51 or the second joint located at the foremost end, and the specific structure of the second traction assembly can also refer to the structure of the first traction assembly, which is not described herein again.

As a preferred embodiment of the present application, at least a partial region of the first insertion tube is flexible and/or at least a partial region of the second insertion tube is flexible. Furthermore, the flexible region of the first insertion tube 21 is connected to the first bending portion 22 and/or the flexible region of the second insertion tube 56 is connected to the second bending portion 57, which on the one hand facilitates the movement of the insertion assembly and the endoscope 5 by the physician and on the other hand reduces the interference and damage caused by the movement to the tissue surrounding the tissue to be examined in the patient.

Where not mentioned in this application, can be accomplished using or referencing existing technology.

The embodiments in the present specification are described in a progressive manner, and the same and similar parts among the embodiments are referred to each other, and each embodiment focuses on the differences from the other embodiments.

The above description is only an example of the present application and is not intended to limit the present application. Various modifications and changes may occur to those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the scope of the claims of the present application.

Claims

1. A cooling medium spraying device for minimally invasive surgery, comprising:

the device comprises an insertion assembly, a heating assembly and a cooling assembly, wherein the insertion assembly is used for being inserted into a surgical object and spraying a cooling medium to a tissue to be detected in the surgical object, and comprises a first insertion pipe, a spray head and a first bending part arranged between the head of the first insertion pipe and the spray head;

a conduit for conveying a cooling medium, at least a region of the conduit extending within the first insertion tube, first bend, and spray head; and

and a first holding part provided at a tail part of the first insertion tube, wherein a moving distance of the insertion assembly can be adjusted by operating the first holding part, and a bent state of the first bending part can be adjusted by operating the first holding part, thereby adjusting a posture of the head.

2. The cooling medium spraying apparatus for minimally invasive surgery according to claim 1,

3. The cooling medium spraying apparatus for minimally invasive surgery according to claim 2,

4. The cooling medium spraying apparatus for minimally invasive surgery according to claim 3,

the spraying device further comprises a traction unit, the traction unit comprises two groups of traction assemblies, each traction assembly comprises two traction ropes, the two traction ropes belonging to the same traction assembly are oppositely arranged, and the deflection angle of the first bending part is limited in the first direction and the second direction;

one end of each traction rope is locked on the first handheld part, and the other end of each traction rope passes through each joint and is fixed on the spray head or the joint positioned at the most front end.

5. The cooling medium spraying apparatus for minimally invasive surgery according to claim 1,

the cooling medium is cooling liquid or cooling gas.

6. An intraoperative tissue detection device for minimally invasive surgery, comprising:

the device for spraying a cooling medium in minimally invasive surgery according to any one of claims 1 to 5;

the endoscope and the cooling medium spraying device are arranged in a separated mode, the endoscope comprises a collecting part which can stretch into the body of an operation object, the collecting part is provided with an image pickup element and a temperature detection element, the image pickup element is used for collecting tissue images, and the temperature detection element is used for detecting the temperature of the tissue in the body of the operation object; and

and the display unit is used for displaying the tissue image and can represent the characteristic quantity of the temperature rise rate of the tissue to be detected.

7. The device for detecting tissue during minimally invasive surgery according to claim 6,

the detection device further comprises a comparison unit, wherein the comparison unit comprises:

the storage module is internally pre-stored with a characteristic quantity A capable of representing the temperature rise rate of a normal tissue;

the calculation module is used for receiving the temperature signal detected by the temperature detection element and calculating the temperature rise rate of the tissue to be detected to obtain a characteristic quantity B for representing the temperature rise rate of the tissue to be detected;

the comparison unit is used for comparing the characteristic quantity A with the characteristic quantity B and transmitting a comparison result to the display unit for displaying.

8. The device of claim 7, further comprising:

a cooling medium reservoir storing a cooling medium for supplying the cooling medium to the spray device; and

a control unit for controlling the temperature of the cooling medium and the spraying amount, spraying duration and spraying interval time of the spraying device.

9. The device for detecting tissue during minimally invasive surgery according to claim 7,

10. The device for detecting tissue during minimally invasive surgery according to claim 9,