CN111417850A - 用于体液检测的电化学传感器和检测装置 - Google Patents

用于体液检测的电化学传感器和检测装置 Download PDF

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CN111417850A
CN111417850A CN201880001542.7A CN201880001542A CN111417850A CN 111417850 A CN111417850 A CN 111417850A CN 201880001542 A CN201880001542 A CN 201880001542A CN 111417850 A CN111417850 A CN 111417850A
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detection
electrochemical sensor
body fluid
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liquid sample
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CN111417850B (zh
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吴峥
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BOE Technology Group Co Ltd
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    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
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    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
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    • A—HUMAN NECESSITIES
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    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
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Abstract

一种用于体液检测的电化学传感器和检测装置。该用于体液检测的电化学传感器包括材料层(110)；材料层(110)包括至少一个亲水区(112)；至少一个检测单元(120)设置在亲水区(112)；亲水区(112)包括采样端口(1120)，被配置为与待检测的液体样品接触；检测单元(120)包括间隔设置的工作电极(121)和对置电极(122)；工作电极(121)包括含有与液体样品中分析物产生化学反应的物质的反应表面(1210)；工作电极(121)和对置电极(122)被配置为检测该化学反应产生的电信号以检测分析物。该用于体液检测的电化学传感器的结构简单，并且可采用纸基材料制作材料层，从而可降低用于体液检测的电化学传感器的成本、便于携带。

Description

PCT国内申请，说明书已公开。

Claims (23)

  1. PCT国内申请，权利要求书已公开。
CN201880001542.7A 2018-09-29 2018-09-29 用于体液检测的电化学传感器和检测装置 Active CN111417850B (zh)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111879838A (zh) * 2020-08-21 2020-11-03 电子科技大学 一种柔性纸基电压型湿度传感器及其制备方法
CN113686941A (zh) * 2021-08-10 2021-11-23 朱浩奇 一种化学传感器

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114113266A (zh) * 2021-12-20 2022-03-01 北京理工大学重庆创新中心 一种用于汗液标志物分析的传感装置

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002054055A1 (en) * 2001-01-04 2002-07-11 Tyson Bioresearch, Inc. Biosensors having improved sample application
CN1370993A (zh) * 2001-02-20 2002-09-25 刘开颜 一种生物传感器及运用该传感器的量化检测方法
US20040245101A1 (en) * 2001-08-29 2004-12-09 Itamar Willner Self-powered biosensor
WO2008088357A1 (en) * 2007-01-18 2008-07-24 Provex Technologies, Llc. Ultrasensitive amperometric saliva glucose sensor strip
WO2009097174A2 (en) * 2008-01-07 2009-08-06 Stc.Unm Electrochemical biosensor
US20100213082A1 (en) * 2009-02-26 2010-08-26 Benjamin Feldman Self-Powered Analyte Sensor
US20100243477A1 (en) * 2008-08-27 2010-09-30 Edwards Lifesciences Corporation Analyte Sensor
WO2014149161A2 (en) * 2013-03-15 2014-09-25 Georgetown University Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate
CN105606682A (zh) * 2016-01-26 2016-05-25 南通大学 一种基于纸基电化学装置的测定葡萄糖的方法
CN106104264A (zh) * 2014-01-21 2016-11-09 加利福尼亚大学董事会 唾液生物传感器以及生物燃料电池
US20180030497A1 (en) * 2015-02-05 2018-02-01 The Regents Of The University Of California Multiple-use renewable electrochemical sensors based on direct drawing of enzymatic inks
CN108548858A (zh) * 2018-06-22 2018-09-18 桂林中辉科技发展有限公司 一种快速测量淀粉酶的电化学试纸及其制备与检测方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6923894B2 (en) * 1999-11-11 2005-08-02 Apex Biotechnology Corporation Biosensor with multiple sampling ways
JP4183902B2 (ja) * 2000-12-27 2008-11-19 松下電器産業株式会社 バイオセンサ
US7311812B2 (en) * 2003-05-30 2007-12-25 Abbott Laboratories Biosensor
WO2005048834A1 (en) * 2003-11-13 2005-06-02 Medtronic Minimed, Inc. Long term analyte sensor array
AU2004322161B2 (en) 2004-08-13 2009-12-03 Egomedical Technologies Ag Analyte test system for determining the concentration of an analyte in a physiological or aqueous fluid
US8062221B2 (en) * 2005-09-30 2011-11-22 Nellcor Puritan Bennett Llc Sensor for tissue gas detection and technique for using the same
US20070169533A1 (en) * 2005-12-30 2007-07-26 Medtronic Minimed, Inc. Methods and systems for detecting the hydration of sensors
US20100169035A1 (en) * 2008-12-29 2010-07-01 Medtronic Minimed, Inc. Methods and systems for observing sensor parameters
US9502730B2 (en) * 2011-11-30 2016-11-22 The Regents Of The University Of California Printed biofuel cells
WO2016028497A1 (en) * 2014-08-21 2016-02-25 Naseri, Sara System and method for non-invasive analysis of bodily fluids
EP3277427A1 (en) * 2015-04-03 2018-02-07 Abbott Laboratories Devices and methods for sample analysis
CN107096581B (zh) 2017-06-13 2019-07-30 中国科学院电子学研究所 微流控纸芯片及应用其的检测系统
AU2018342475B2 (en) * 2017-09-29 2021-07-01 W.L. Gore & Associates, Inc. Fluid handling detectors

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002054055A1 (en) * 2001-01-04 2002-07-11 Tyson Bioresearch, Inc. Biosensors having improved sample application
CN1370993A (zh) * 2001-02-20 2002-09-25 刘开颜 一种生物传感器及运用该传感器的量化检测方法
US20040245101A1 (en) * 2001-08-29 2004-12-09 Itamar Willner Self-powered biosensor
WO2008088357A1 (en) * 2007-01-18 2008-07-24 Provex Technologies, Llc. Ultrasensitive amperometric saliva glucose sensor strip
WO2009097174A2 (en) * 2008-01-07 2009-08-06 Stc.Unm Electrochemical biosensor
US20100243477A1 (en) * 2008-08-27 2010-09-30 Edwards Lifesciences Corporation Analyte Sensor
US20100213082A1 (en) * 2009-02-26 2010-08-26 Benjamin Feldman Self-Powered Analyte Sensor
WO2014149161A2 (en) * 2013-03-15 2014-09-25 Georgetown University Microfluidic systems for electrochemical transdermal glucose sensing using a paper-based or other wicking substrate
CN106104264A (zh) * 2014-01-21 2016-11-09 加利福尼亚大学董事会 唾液生物传感器以及生物燃料电池
US20180030497A1 (en) * 2015-02-05 2018-02-01 The Regents Of The University Of California Multiple-use renewable electrochemical sensors based on direct drawing of enzymatic inks
CN105606682A (zh) * 2016-01-26 2016-05-25 南通大学 一种基于纸基电化学装置的测定葡萄糖的方法
CN108548858A (zh) * 2018-06-22 2018-09-18 桂林中辉科技发展有限公司 一种快速测量淀粉酶的电化学试纸及其制备与检测方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
张先恩: "《生物传感技术原理与应用》", 31 May 1991, 吉林科学技术出版社, pages: 121 - 123 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111879838A (zh) * 2020-08-21 2020-11-03 电子科技大学 一种柔性纸基电压型湿度传感器及其制备方法
CN113686941A (zh) * 2021-08-10 2021-11-23 朱浩奇 一种化学传感器

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EP3862750A4 (en) 2022-07-27
CN111417850B (zh) 2023-09-05
EP3862750A1 (en) 2021-08-11
US11733195B2 (en) 2023-08-22
US20210325332A1 (en) 2021-10-21
WO2020062143A1 (zh) 2020-04-02

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