CN111413254B - Method for testing thick paste viscosity - Google Patents
Method for testing thick paste viscosity Download PDFInfo
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- CN111413254B CN111413254B CN202010314791.0A CN202010314791A CN111413254B CN 111413254 B CN111413254 B CN 111413254B CN 202010314791 A CN202010314791 A CN 202010314791A CN 111413254 B CN111413254 B CN 111413254B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
- G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
- G01N11/06—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture by timing the outflow of a known quantity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
- G01N11/10—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material
- G01N11/14—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane
Abstract
The invention discloses a method for testing thick paste viscosity, which comprises the following steps: step one, taking 25g of the soft extract after being dried, then converting the dried soft extract into a soft extract sampling amount according to the specific gravity of different soft extracts, placing the converted soft extract into a 100ml volumetric flask, adding water to dilute to a scale, shaking up, and measuring by a plano viscometer with the inner diameter of a capillary tube of 0.8mm according to a viscometry method. The testing method adopted by the invention can effectively test the thick paste viscosity, is more innovative compared with the prior method, is simple and convenient, has strong practicability, and can realize technical parameter guidance for the forming of some dosage forms in a preparation workshop section.
Description
Technical Field
The invention relates to the technical field of thick paste viscosity detection, in particular to a method for testing thick paste viscosity.
Background
Viscosity refers to the property of a fluid to create resistance to flow. This method is expressed in terms of kinematic viscosity, or intrinsic viscosity. Kinematic viscosity is also known as the viscosity coefficient (η). Assuming that the fluid is divided into different parallel layers, the force applied per unit area in the tangential direction of the layers, i.e. the shear stress (τ), is given in Pa. Under the action of shear stress, gradient velocity flows occur in all parallel layers of the fluid. The difference in flow velocity of each fluid layer per unit length in the vertical direction is called the shear rate (D) and is given by s -1 . The dynamic viscosity is the ratio of the two, the expression is eta = d tau/dD, and the unit is Pa · S. Since the Pa unit is too large, mPas are often used. The relationship between the shear rate and the shear stress of a fluid reflects the rheological property of the fluid, and the fluid can be divided into a Newtonian fluid (or an ideal fluid) and a non-Newtonian fluid according to the change relationship of the shear rate and the shear stress of the fluid. Without yield force, the shear stress and shear rate of newtonian fluids are linearly changing, and both pure liquids and solutions of low molecular substances fall into this category. The shear stress and shear rate of non-newtonian fluids are non-linearly changing, and concentrated solutions, suspensions, emulsions of high polymers and surfactant solutions are all included in this class.
When the temperature is measured to be constant, the dynamic viscosity of the Newtonian fluid is a constant value and does not change along with the change of the shear rate. While the dynamic viscosity of non-Newtonian fluids varies with shear rateThe dynamic viscosity value measured at a certain shear rate is also called apparent viscosity. Kinematic viscosity is the ratio of the dynamic viscosity of a Newtonian fluid to its density at the same temperature, in m 2 and/S. Cause m 2 Too large a/s unit, mm is often used 2 And s. The viscosity η 0 of the solvent is often increased by the dissolution of the high polymer, and the ratio (η/η 0) of the viscosity η of the solution to the viscosity η 0 of the solvent is called the relative viscosity (η r) and is generally expressed by the ratio (T/T0) of the flow-out time in a wurtzite viscometer; when the concentration of the polymer solution is relatively dilute, the ratio of the logarithmic value of the relative viscosity of the polymer solution to the concentration of the polymer solution is the characteristic viscosity [ eta ] of the polymer]. The average molecular weight can be calculated from the intrinsic viscosity of the polymer. A viscometer is used for measuring viscosity. There are various types of viscometers.
The invention aims at the detection of the thick paste viscosity and ensures that technical parameter guidance is made for the forming of some dosage forms in a preparation process, thereby providing a method for testing the thick paste viscosity.
Disclosure of Invention
The invention aims to provide a method for testing thick paste viscosity, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
a method for testing thick paste viscosity comprises the following steps:
step one, taking 25g of the soft extract after being dried, then carrying out drying conversion on the soft extract sampling amount according to different soft extract specific gravities, placing the converted soft extract amount into a 100ml volumetric flask, adding water to dilute to a scale, shaking up, and measuring by using a planisch viscometer with the inner diameter of a capillary tube of 0.8mm according to a viscometry method;
step two, taking 1 appropriate Ping's capillary viscometer, connecting a rubber tube on the branch tube F, plugging the tube opening 2 with a finger, inverting the viscometer, inserting the tube opening 1 into the sample, exhausting air from the other end of the rubber tube to fill the sample with the balls C and A and reach the measurement line m 2 Lifting the viscometer and rapidly reversing to wipe off the test sample adhered to the outside of the tube;
step three, taking off the rubber tube to connect the rubber tube to the tube opening 1Vertically fixing the viscometer in a constant temperature water bath, making the liquid level of the water bath higher than the middle part of the ball C, standing for 15 minutes, and then exhausting air from the other end of the rubber tube to make the sample fill the ball A and exceed the measurement line m 1 Opening the rubber tube to make the sample fall down in the tube, and accurately recording the liquid level self-measuring line m by using a stopwatch 1 Down to the measuring line m 2 The time of outflow of (d);
and step four, the sample is not reloaded, the measurement is repeated for 3 times according to the method, the difference value between the measured value and the average value each time does not exceed +/-0.25% of the average value, another part of the sample is taken to operate the same method, and the total average value obtained by sampling and measuring twice in sequence is calculated according to the following formula, so that the kinematic viscosity of the sample is obtained.
Preferably, the viscometry measures one of three measurement methods which can be selected from a plano-capillary viscometer, a wurtzite capillary viscometer and a rotary viscometer.
Preferably, the Ping-Mars capillary viscometer and the Wu-Mars capillary viscometer are suitable for measuring the kinematic viscosity of Newtonian fluid; the rotary viscometer is suitable for measuring the dynamic viscosity of Newtonian fluid or non-Newtonian fluid.
Preferably, the calculation equation of kinematic viscosity is: v = Kt (1)
η＝10 -6 Ktρ (2)
K is the viscometer constant measured by standard liquid with known viscosity, mm 2 /s 2 (ii) a t is the measured average outflow time, s; rho is the density of the sample at the same temperature, g/cm 3 (ii) a The measurement temperature should be 20 ℃. + -. 0.1 ℃ and, in this case,
is the relative density of the test article at 20 ℃.
Compared with the prior art, the invention has the following beneficial effects:
the testing method adopted by the invention can effectively test the thick paste viscosity, is more innovative compared with the prior method, is simple and convenient, has strong practicability, and can realize technical parameter guidance for the forming of some dosage forms in a preparation workshop section.
Drawings
FIG. 1 is a schematic diagram of the present invention in the context of a viscometer in a plano capillary.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
Example 1:
the method for testing the thick paste viscosity comprises the following steps:
step one, taking 25g of the soft extract after being dried, then carrying out drying conversion on the soft extract sampling amount according to different soft extract specific gravities, placing the converted soft extract amount into a 100ml volumetric flask, adding water to dilute to a scale, shaking up, and measuring by using a planisch viscometer with the inner diameter of a capillary tube of 0.8mm according to a viscometry method;
and step two, selecting a capillary viscometer with a proper inner diameter specification according to the viscosity range (table 1) of the sample to be tested, periodically checking or calibrating to meet relevant regulations, and obtaining the viscosity constant K value of the capillary. The method comprises collecting sample, taking 1 Ping-shi capillary viscometer according to the specification of each item, connecting a rubber tube to branch tube F, blocking tube orifice 2 with finger, inverting viscometer, inserting tube orifice 1 into sample, and exhausting air from the other end of rubber tube to fill sample with balls C and A and reach measurement line m 2 Lifting the viscometer and rapidly reversing to wipe off the test sample adhered to the outside of the tube;
step three, taking down the rubber tube to connect the rubber tube to the tube opening 1, vertically fixing the viscometer in a constant-temperature water bath, enabling the liquid level of the water bath to be higher than the middle part of the ball C, standing for 15 minutes, and then exhausting air from the other end of the rubber tube to enable the sample to be filled with the ball A and exceed the measurementLine m 1 Opening the rubber tube to make the sample fall down in the tube, and accurately recording the liquid level self-measuring line m by using a stopwatch 1 Down to the measuring line m 2 The time of outflow of (d);
and step four, the sample is not reloaded, the measurement is repeated for 3 times according to the method, the difference value between the measured value and the average value does not exceed +/-0.25% of the average value every time, another part of the sample is taken and operated according to the method, and the total average value measured by sampling twice is calculated according to the following formula, so that the kinematic viscosity of the sample is obtained.
The viscometry method of this embodiment can be selected from among three measurement methods, i.e., a Ping-Marek capillary viscometer, a Ubbelohde capillary viscometer and a rotational viscometer.
The viscometer of the Ping-Marek's capillary and the viscometer of the Wu-Marian capillary are suitable for measuring the kinematic viscosity of Newtonian fluid; the rotary viscometer is suitable for measuring the dynamic viscosity of Newtonian fluid or non-Newtonian fluid.
The kinematic viscosity calculation equation for this example is: v = Kt (1)
η＝10 -6 Ktρ (2)
K is the viscometer constant measured by standard liquid with known viscosity, mm 2 /s 2 (ii) a t is the measured average outflow time, s; rho is the density of the sample at the same temperature, g/cm 3 (ii) a The measurement temperature should be 20 ℃. + -. 0.1 ℃ and, in this case,
is the relative density of the test article at 20 ℃.
Example 2:
the method for testing the thick paste viscosity comprises the following steps:
step one, taking 25g of the soft extract after being dried, then carrying out drying conversion on the soft extract sampling amount according to different soft extract specific gravities, placing the converted soft extract amount into a 100ml volumetric flask, adding water to dilute to a scale, shaking up, and measuring by using a planisch viscometer with the inner diameter of a capillary tube of 0.8mm according to a viscometry method;
and step two, selecting a capillary viscometer with a proper inner diameter specification according to the viscosity range (table 1) of the sample to be tested, periodically checking or calibrating to meet relevant regulations, and obtaining the viscosity constant K value of the capillary. The method comprises collecting sample, taking 1 Ping-shi capillary viscometer according to the specification of each item, connecting a rubber tube to branch tube F, blocking tube orifice 2 with finger, inverting viscometer, inserting tube orifice 1 into sample, and exhausting air from the other end of rubber tube to fill sample with balls C and A and reach measurement line m 2 Lifting the viscometer and rapidly reversing to wipe off the test sample adhered to the outside of the tube;
thirdly, taking down the rubber tube to connect the rubber tube to the tube opening 1, vertically fixing the viscometer in a constant-temperature water bath, enabling the liquid level of the water bath to be higher than the middle part of the ball C, standing for 15 minutes, and then exhausting air from the other end of the rubber tube to enable the sample to be filled with the ball A and exceed the measured line m 1 Opening the rubber tube to make the sample fall down in the tube, and accurately recording the liquid level self-measuring line m by using a stopwatch 1 Down to the measuring line m 2 The time of outflow of (d);
and step four, the sample is not reloaded, the measurement is repeated for 3 times according to the method, the difference value between the measured value and the average value each time does not exceed +/-0.25% of the average value, another part of the sample is taken to operate the same method, and the total average value obtained by sampling and measuring twice in sequence is calculated according to the following formula, so that the kinematic viscosity of the sample is obtained.
The kinematic viscosity calculation equation for this example is: v = Kt (1)
η＝10 -6 Ktρ (2)
K is the viscometer constant measured by standard liquid with known viscosity, mm 2 /s 2 (ii) a t is the measured average outflow time, s; rho is the density of the sample at the same temperature, g/cm 3 (ii) a The measurement temperature should be 20 ℃. + -. 0.1 ℃ and, in this case,
is a test articleRelative density at 20 ℃.
TABLE 1 Leeb viscometer measurement Range and Specifications
Note: the minimum flow-out time for the 0 th plano-capillary viscometer was 350 seconds, and all others were 200 seconds.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present specification describes embodiments, not every embodiment includes only a single embodiment, and such description is for clarity purposes only, and it is to be understood that all embodiments may be combined as appropriate by one of ordinary skill in the art to form other embodiments as will be apparent to those of skill in the art from the description herein.
Claims (4)
1. A method for testing thick paste viscosity is characterized by comprising the following steps:
step one, taking 25g of the soft extract after being dried, then carrying out drying conversion on the soft extract sampling amount according to different soft extract specific gravities, placing the converted soft extract amount into a 100ml volumetric flask, adding water to dilute to a scale, shaking up, and measuring by using a planisch viscometer with the inner diameter of a capillary tube of 0.8mm according to a viscometry method;
step two, taking 1 appropriate Ping's capillary viscometer, connecting a rubber tube on the branch tube F, plugging the tube opening 2 with a finger, inverting the viscometer, inserting the tube opening 1 into the sample, and taking out the rubber tubeThe other end is pumped to fill the test sample with the balls C and A and reach the measuring line m 2 Lifting the viscometer and rapidly reversing to wipe off the test sample adhered to the outside of the tube;
thirdly, taking down the rubber tube to connect the rubber tube to the tube opening 1, vertically fixing the viscometer in a constant-temperature water bath, enabling the liquid level of the water bath to be higher than the middle part of the ball C, standing for 15 minutes, and then exhausting air from the other end of the rubber tube to enable the sample to be filled with the ball A and exceed the measured line m 1 Opening the rubber tube to make the sample fall down in the tube, and accurately recording the liquid level self-measuring line m by using a stopwatch 1 Down to the measuring line m 2 The time of outflow of (d);
and step four, the sample is not reloaded, the measurement is repeated for 3 times according to the method, the difference value between the measured value and the average value each time does not exceed +/-0.25% of the average value, another part of the sample is taken to operate the same method, and the total average value obtained by sampling and measuring twice in sequence is calculated according to the following formula, so that the kinematic viscosity of the sample is obtained.
2. The method of claim 1, wherein the viscometry determines one of three measurement methods selected from the group consisting of a Ping-Marek viscometer, a Ubbelohde viscometer, and a rotational viscometer.
3. The method for testing thick paste viscosity according to claim 2, wherein the Ping-Mars capillary viscometer and the Wu-Mars capillary viscometer are suitable for measuring the kinematic viscosity of Newtonian fluid; the rotary viscometer is suitable for measuring Newtonian fluid or non-Newtonian fluid dynamic viscosity.
4. The method for testing thick paste viscosity according to claim 1, wherein the calculation equation of kinematic viscosity is as follows: v = Kt (1)
η＝10 -6 Ktρ (2)
K is the viscometer constant measured by standard liquid with known viscosity, mm 2 /s 2 (ii) a t is the measured average outflow time, s; rho is the density of the sample at the same temperature, g/cm 3 (ii) a The measurement temperature should be 20 deg.c + -0.1 deg.c, at which time,
is the relative density of the test article at 20 ℃.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200538492A (en) * | 2004-05-07 | 2005-12-01 | Zimmer Ag | Method for process control during the manufacture of polyesters or copolyesters |
| US7730769B1 (en) * | 2006-05-24 | 2010-06-08 | Kwon Kyung C | Capillary viscometers for use with Newtonian and non-Newtonian fluids |
| CN104116963A (en) * | 2014-06-18 | 2014-10-29 | 华南农业大学 | Radix fici simplicissimae compound preparation for resisting oxidation and delaying senescence and preparation method of radix fici simplicissimae compound preparation |
| CN110132793A (en) * | 2019-04-19 | 2019-08-16 | 福建师范大学 | A kind of polymer molecular weight test device and test method |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200538492A (en) * | 2004-05-07 | 2005-12-01 | Zimmer Ag | Method for process control during the manufacture of polyesters or copolyesters |
| US7730769B1 (en) * | 2006-05-24 | 2010-06-08 | Kwon Kyung C | Capillary viscometers for use with Newtonian and non-Newtonian fluids |
| CN104116963A (en) * | 2014-06-18 | 2014-10-29 | 华南农业大学 | Radix fici simplicissimae compound preparation for resisting oxidation and delaying senescence and preparation method of radix fici simplicissimae compound preparation |
| CN110132793A (en) * | 2019-04-19 | 2019-08-16 | 福建师范大学 | A kind of polymer molecular weight test device and test method |
Non-Patent Citations (1)
| Title |
|---|
| 孔晓锋 ; 古丽沙依拉 ; 古丽曼 ; .平氏黏度计测定标准黏度液运动黏度及测量不确定度的评定.2011,(07),全文. * |
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