CN111409344A - Medicine packaging film and preparation method thereof - Google Patents

Medicine packaging film and preparation method thereof Download PDF

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Publication number
CN111409344A
CN111409344A CN202010289653.1A CN202010289653A CN111409344A CN 111409344 A CN111409344 A CN 111409344A CN 202010289653 A CN202010289653 A CN 202010289653A CN 111409344 A CN111409344 A CN 111409344A
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China
Prior art keywords
parts
packaging film
polyester layer
aluminized polyester
weight
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CN202010289653.1A
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Chinese (zh)
Inventor
肖瑶
张辉
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Sichuan Huili Industrial Co Ltd
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Sichuan Huili Industrial Co Ltd
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Priority to CN202010289653.1A priority Critical patent/CN111409344A/en
Publication of CN111409344A publication Critical patent/CN111409344A/en
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D7/00—Producing flat articles, e.g. films or sheets
    • B29D7/01—Films or sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B32B27/20—Layered products comprising a layer of synthetic resin characterised by the use of special additives using fillers, pigments, thixotroping agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B32B27/22—Layered products comprising a layer of synthetic resin characterised by the use of special additives using plasticisers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/34—Layered products comprising a layer of synthetic resin comprising polyamides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/36—Layered products comprising a layer of synthetic resin comprising polyesters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B33/00—Layered products characterised by particular properties or particular surface features, e.g. particular surface coatings; Layered products designed for particular purposes not covered by another single class
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
    • B65D65/38—Packaging materials of special type or form
    • B65D65/40—Applications of laminates for particular packaging purposes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J5/00—Manufacture of articles or shaped materials containing macromolecular substances
    • C08J5/18—Manufacture of films or sheets
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C26/00—Coating not provided for in groups C23C2/00 - C23C24/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2250/00—Layers arrangement
    • B32B2250/24—All layers being polymeric
    • B32B2250/246—All polymers belonging to those covered by groups B32B27/32 and B32B27/30
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/10—Coating on the layer surface on synthetic resin layer or on natural or synthetic rubber layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2255/00—Coating on the layer surface
    • B32B2255/20—Inorganic coating
    • B32B2255/205—Metallic coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2262/00—Composition or structural features of fibres which form a fibrous or filamentary layer or are present as additives
    • B32B2262/10—Inorganic fibres
    • B32B2262/101—Glass fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/30—Properties of the layers or laminate having particular thermal properties
    • B32B2307/308—Heat stability
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00—Properties of the layers or laminate
    • B32B2307/50—Properties of the layers or laminate having particular mechanical properties
    • B32B2307/552—Fatigue strength
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00—Containers; Receptacles
    • B32B2439/80—Medical packaging
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2367/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C08J2367/04—Polyesters derived from hydroxy carboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2467/00—Characterised by the use of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2477/00—Characterised by the use of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K13/00—Use of mixtures of ingredients not covered by one single of the preceding main groups, each of these compounds being essential
    • C08K13/04—Ingredients characterised by their shape and organic or inorganic ingredients
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
    • C08K3/20—Oxides; Hydroxides
    • C08K3/22—Oxides; Hydroxides of metals
    • C08K2003/2237—Oxides; Hydroxides of metals of titanium
    • C08K2003/2241—Titanium dioxide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K2201/00—Specific properties of additives
    • C08K2201/011—Nanostructured additives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/02—Elements
    • C08K3/04—Carbon
    • C08K3/042—Graphene or derivatives, e.g. graphene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/13—Phenols; Phenolates
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/13—Phenols; Phenolates
    • C08K5/134—Phenols containing ester groups
    • C08K5/1345—Carboxylic esters of phenolcarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K7/00—Use of ingredients characterised by shape
    • C08K7/02—Fibres or whiskers
    • C08K7/04—Fibres or whiskers inorganic
    • C08K7/14—Glass

Abstract

The invention discloses a medicine packaging film and a preparation method thereof, wherein the medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, and the aluminized polyester layer comprises the following components in parts by weight: 30-40 parts of polycaprolactone, 20-25 parts of copolyester, 20-30 parts of polyesteramide, 3-8 parts of nano titanium dioxide, 4-12 parts of tert-butyl benzenediol and 10-25 parts of gallic acid lactone. The invention solves the problem that the aluminized polyester layer of the existing packaging film is easy to age in the using process.

Description

Medicine packaging film and preparation method thereof
Technical Field
The invention relates to the technical field of medicine packaging, in particular to a medicine packaging film and a preparation method thereof.
Background
Currently, solid drug packaging mainly includes glass bottles, plastic bottles and film packaging. Because the glass bottle and the plastic bottle are rigid and are only suitable for medicines such as medicine granules or powder, the solid bulk drug cannot be solved. Therefore, for some solid raw medicines, packaging films are usually adopted for packaging, or the packaging films are prepared into packaging bags for medicine packaging.
The existing packaging film mainly considers tensile resistance and thermal stability in the preparation process, the aging of the packaging film in the use process can be ignored, and most of the packaging films can have an aging phenomenon after being used for a period of time. The packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, and the polyethylene layer has certain ageing resistance, so that the ageing of the packaging film is mainly reflected in the aluminized polyester layer, the aluminized polyester layer becomes fragile after ageing, and the aluminized polyester layer is cracked or even broken when being rubbed or pulled and extruded on the outer side.
Disclosure of Invention
The invention aims to provide a medicine packaging film, which solves the problem that an aluminized polyester layer of the existing packaging film is easy to age in the using process.
In addition, the invention also provides a preparation method of the medicine packaging film.
The invention is realized by the following technical scheme:
the medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, wherein the aluminized polyester layer comprises the following components in parts by weight:
30-40 parts of polycaprolactone, 20-25 parts of copolyester, 20-30 parts of polyesteramide, 3-8 parts of nano titanium dioxide, 4-12 parts of tert-butyl benzenediol and 10-25 parts of gallic acid lactone.
The medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, wherein the aluminized polyester layer comprises the following components in parts by weight:
30-40 parts of polycaprolactone, 20-25 parts of copolyester, 20-30 parts of polyesteramide, 3-8 parts of nano titanium dioxide, 4-12 parts of tert-butyl benzenediol and 10-25 parts of gallic acid lactone.
The polyethylene layer adopts the prior art, and comprises the following components: polyethylene, natural rubber, plasticizers and stabilizers.
In the formulation of the present invention: the polycaprolactone, the copolyester and the polyesteramide are base materials of the aluminized polyester layer, and the aluminized polyester layer prepared by only adopting the base materials is easy to age in the using process; the tert-butyl benzenediol has an excellent antioxidant effect, the anti-aging function of the aluminized polyester layer can be obviously improved by adding the tert-butyl benzenediol, the gallic acid lactone has a certain antioxidant effect, and meanwhile, the gallic acid lactone has good thermal stability, the nano titanium dioxide also has the antioxidant effect, and the tert-butyl benzenediol can be assisted in improving the anti-aging performance.
Through a large number of experiments, the applicant finds that when the tert-butyl benzenediol and the gallic acid lactone are added simultaneously, the thermal stability and the anti-aging function of the aluminized polyester layer can be improved, the anti-aging function is obviously improved compared with that when the tert-butyl benzenediol or the gallic acid lactone is added independently, particularly when the tert-butyl benzenediol and the gallic acid lactone are added according to the weight ratio of 1:2, the effect is optimal, and the anti-aging function of the prepared aluminized polyester layer is obviously improved by adding the nano titanium dioxide.
According to the invention, the nano titanium dioxide, the tert-butyl benzenediol and the gallic acid lactone are added into the base material for preparing the aluminum-plated polyester layer, and the tert-butyl benzenediol and the gallic acid lactone generate a synergistic effect, so that the anti-aging function is obviously improved compared with that of the method of independently adding tert-butyl benzenediol or gallic acid lactone, and the nano titanium dioxide is used as an auxiliary material, so that the anti-aging function of the prepared aluminum-plated polyester layer is obviously improved. Therefore, the invention solves the problem that the aluminized polyester layer of the existing packaging film is easy to age in the using process. And simultaneously has good thermal stability.
Further, the aluminized polyester layer is composed of the following components in parts by weight:
35 parts of polycaprolactone, 25 parts of copolyester, 30 parts of polyesteramide, 6 parts of nano titanium dioxide, 12 parts of tert-butyl benzenediol and 24 parts of gallic acid lactone.
Further, the composition also comprises the following components in parts by weight:
1-5 parts of graphene.
The graphene has certain lubricity and high toughness, is not only beneficial to playing a lubricating role when raw materials are mixed, improves the uniform mixing effect of materials, but also can enhance the toughness of the aluminized polyester layer, improves the tensile resistance of the aluminized polyester layer while meeting the ageing resistance function of the aluminized polyester layer, and prolongs the service life of the aluminized polyester layer.
Further, the composition also comprises the following components in parts by weight:
8-15 parts of glass fiber.
The glass fiber can enhance the toughness of the aluminized polyester layer and improve the tensile resistance of the aluminized polyester layer.
Further, the composition also comprises the following components in parts by weight:
1-3 parts of ultraviolet absorbent.
The ultraviolet absorbent can prevent the corrosion of ultraviolet rays to the aluminized polyester layer, can improve the ageing resistance and the stability of the aluminized polyester layer when the aluminized polyester layer is used outdoors,
a preparation method of a medicine packaging film comprises the following steps:
1) weighing materials: weighing the components in parts by weight respectively;
2) mixing materials: uniformly mixing polycaprolactone, copolyester and polyesteramide, adding gallic acid lactone in batches under a stirring state, uniformly mixing, adding nano titanium dioxide and tert-butyl benzenediol, and uniformly stirring;
3) and extrusion molding: extruding the uniformly mixed materials at 380-420 ℃ by a double-rod screw extruder to prepare a polyester material;
4) and preparing a film: preparing a polyester film from a polyester material on a film preparation machine;
5) and aluminizing: aluminizing the polyester film by adopting a spraying technology to prepare an aluminized polyester layer;
6) and compounding: compounding the aluminized polyester layer and the polyethylene layer to prepare the medicine packaging film.
In the preparation method, the nano titanium dioxide, the tert-butyl benzenediol and the gallic acid lactone in a certain proportion are added into the raw materials, and the tert-butyl benzenediol and the gallic acid lactone generate a synergistic effect, so that the anti-aging function is obviously improved compared with that of the method of independently adding the tert-butyl benzenediol or the gallic acid lactone, and the anti-aging function of the prepared aluminized polyester layer is obviously improved by adding the nano titanium dioxide.
Compared with the prior art, the invention has the following advantages and beneficial effects:
according to the invention, the nano titanium dioxide, the tert-butyl benzenediol and the gallic acid lactone are added into the base material for preparing the aluminum-plated polyester layer, and the tert-butyl benzenediol and the gallic acid lactone generate a synergistic effect, so that the anti-aging function is obviously improved compared with that of the method of independently adding tert-butyl benzenediol or gallic acid lactone, and the nano titanium dioxide is used as an auxiliary material, so that the anti-aging function of the prepared aluminum-plated polyester layer is obviously improved. Therefore, the invention solves the problem that the aluminized polyester layer of the existing packaging film is easy to age in the using process. And simultaneously has good thermal stability.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not used as limitations of the present invention.
Example 1:
the medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, wherein the aluminized polyester layer comprises the following components in parts by weight:
30 parts of polycaprolactone, 20 parts of copolyester, 20 parts of polyesteramide, 3 parts of nano titanium dioxide, 12 parts of tert-butyl benzenediol and 25 parts of gallic acid lactone.
Example 2:
the medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, wherein the aluminized polyester layer comprises the following components in parts by weight:
40 parts of polycaprolactone, 25 parts of copolyester, 30 parts of polyesteramide, 8 parts of nano titanium dioxide, 4 parts of tert-butyl benzenediol and 10 parts of gallic acid lactone.
Example 3:
the medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, wherein the aluminized polyester layer comprises the following components in parts by weight:
35 parts of polycaprolactone, 25 parts of copolyester, 30 parts of polyesteramide, 6 parts of nano titanium dioxide, 12 parts of tert-butyl benzenediol and 24 parts of gallic acid lactone.
Example 4:
the medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, wherein the aluminized polyester layer comprises the following components in parts by weight:
35 parts of polycaprolactone, 25 parts of copolyester, 30 parts of polyesteramide, 6 parts of nano titanium dioxide, 12 parts of tert-butyl benzenediol and 24 parts of gallic acid lactone; 5 parts of graphene.
Example 5:
the medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, wherein the aluminized polyester layer comprises the following components in parts by weight:
35 parts of polycaprolactone, 25 parts of copolyester, 30 parts of polyesteramide, 6 parts of nano titanium dioxide, 12 parts of tert-butyl benzenediol and 24 parts of gallic acid lactone; 1 part of graphene and 15 parts of glass fiber.
Example 6:
the medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, wherein the aluminized polyester layer comprises the following components in parts by weight:
35 parts of polycaprolactone, 25 parts of copolyester, 30 parts of polyesteramide, 6 parts of nano titanium dioxide, 12 parts of tert-butyl benzenediol and 24 parts of gallic acid lactone; 3 parts of graphene, 8 parts of glass fiber and 3 parts of phenyl o-hydroxybenzoate.
Comparative example 1:
the present example is based on example 3, and differs from example 3 in that: does not contain gallic acid lactone.
Comparative example 2:
the present example is based on example 3, and differs from example 3 in that: without tert-butyl benzenediol.
Comparative example 3:
the present example is based on example 3, and differs from example 3 in that: the content of the tert-butyl benzenediol is as follows: 3 parts by weight, the content of gallic acid lactone is: 30 parts by weight.
Comparative example 4:
the present example is based on example 3, and differs from example 3 in that: the content of the tert-butyl benzenediol is as follows: 15 parts by weight of gallic acid lactone: 5 parts by weight.
The packaging films prepared in examples 1 to 6 and comparative examples 1 to 4 (the specifications of the packaging films are all 1.5mm in thickness and 10cm by 50cm) were subjected to 500-hour xenon lamp aging test according to GB/T16422.2-1999, and the appearance change of the packaging films was observed, wherein the appearance change such as color was observed with naked eyes and was stretched by a tensile machine (CTM8000), and the results were as follows:
example 1:
before 400 hours, the packaging film has no obvious color and deformation, and after 400-500 hours, the packaging film has yellow color, has no foaming, cracking and buckling deformation in a natural state, and has fine cracks under a 50N stretching state.
Example 2:
before 350 hours, the packaging film has no obvious color and deformation, and after 500 hours, the packaging film has yellow color, has no foaming, cracking and buckling deformation in a natural state, and has more fine cracks under a 50N stretching state.
Example 3:
before 400 hours, the packaging film has no color and deformation, and after 400-500 hours, the packaging film has slight yellow color, has no foaming, cracking and buckling deformation in a natural state, has no crack in a 50N stretching state, and has cracks in a 100N stretching state.
Example 4:
before 400 hours, the packaging film has no color and deformation, and after 400-500 hours, the packaging film has slight yellow color, has no bubbling, cracking and buckling deformation in a natural state, has no cracks in a 50N stretching state, and has a small amount of cracks in a 100N stretching state.
Example 5:
before 400 hours, the packaging film has no color and deformation, and after 400-500 hours, the packaging film has slight yellow color, has no foaming, cracking and buckling deformation in a natural state, has no crack in a 50N stretching state, and has no crack in a 100N stretching state.
Example 6:
before 400 hours, the packaging film has no color and deformation, and after 400-500 hours, the packaging film has no color and deformation, has no foaming, cracking and buckling deformation in a natural state, has no crack in a 50N stretching state, and has no crack in a 100N stretching state.
Comparative example 1:
before 100 hours, the packaging film has no color and deformation, and after 100 hours and 500 hours, the packaging film has slight yellow color, does not blister and crack in a natural state, but has buckling deformation, and cracks appear in a 50N stretching state.
Comparative example 2:
before 100 hours, the packaging film has no color and deformation, and after 100 hours and 500 hours, the packaging film has slight yellow color and no bubbles in a natural state, but cracks and slight buckling deformation occur.
Comparative example 3:
before 200 hours, the packaging film has no color and deformation, and after 200 hours and 500 hours, the packaging film has slight yellow color and no bubbles in a natural state, but cracks and slight buckling deformation occur.
Comparative example 4:
before 240 hours, the packaging film has no color and deformation, and after 500 hours, the packaging film has slight yellow color, does not blister and crack in a natural state, but has buckling deformation, and cracks appear in a 50N stretching state.
A preparation method of a medicine packaging film comprises the following steps:
1) weighing materials: weighing the components in parts by weight respectively;
2) mixing materials: uniformly mixing polycaprolactone, copolyester and polyesteramide at room temperature, adding gallic acid lactone in batches under the stirring state, uniformly mixing, adding nano titanium dioxide and tert-butyl benzenediol, and uniformly stirring;
3) and extrusion molding: extruding the uniformly mixed materials at 380-420 ℃ by a double-rod screw extruder to prepare a polyester material;
4) and preparing a film: preparing a polyester film from a polyester material on a film preparation machine;
5) and aluminizing: aluminizing the polyester film by adopting a spraying technology to prepare an aluminized polyester layer;
6) and compounding: compounding the aluminized polyester layer and the polyethylene layer to prepare the medicine packaging film.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (7)

1. The medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, and is characterized in that the aluminized polyester layer comprises the following components in parts by weight:
30-40 parts of polycaprolactone, 20-25 parts of copolyester, 20-30 parts of polyesteramide, 3-8 parts of nano titanium dioxide, 4-12 parts of tert-butyl benzenediol and 10-25 parts of gallic acid lactone.
2. The medicine packaging film sequentially comprises a polyethylene layer and an aluminized polyester layer from inside to outside, and is characterized in that the aluminized polyester layer comprises the following components in parts by weight:
30-40 parts of polycaprolactone, 20-25 parts of copolyester, 20-30 parts of polyesteramide, 3-8 parts of nano titanium dioxide, 4-12 parts of tert-butyl benzenediol and 10-25 parts of gallic acid lactone.
3. The pharmaceutical packaging film of claim 2, wherein the aluminized polyester layer comprises the following components in parts by weight:
35 parts of polycaprolactone, 25 parts of copolyester, 30 parts of polyesteramide, 6 parts of nano titanium dioxide, 12 parts of tert-butyl benzenediol and 24 parts of gallic acid lactone.
4. The pharmaceutical packaging film of claim 1, further comprising the following components in parts by weight:
1-5 parts of graphene.
5. The pharmaceutical packaging film of claim 1, further comprising the following components in parts by weight:
8-15 parts of glass fiber.
6. The pharmaceutical packaging film of claim 1, further comprising the following components in parts by weight:
1-3 parts of ultraviolet absorbent.
7. A method of manufacturing a pharmaceutical packaging film according to claim 1 or 2, comprising the steps of:
1) weighing materials: weighing the components in parts by weight respectively;
2) mixing materials: uniformly mixing polycaprolactone, copolyester and polyesteramide, adding gallic acid lactone in batches under a stirring state, uniformly mixing, adding nano titanium dioxide and tert-butyl benzenediol, and uniformly stirring;
3) and extrusion molding: extruding the uniformly mixed materials at 380-420 ℃ by a double-rod screw extruder to prepare a polyester material;
4) and preparing a film: preparing a polyester film from a polyester material on a film preparation machine;
5) and aluminizing: aluminizing the polyester film by adopting a spraying technology to prepare an aluminized polyester layer;
6) and compounding: compounding the aluminized polyester layer and the polyethylene layer to prepare the medicine packaging film.
CN202010289653.1A 2020-04-14 2020-04-14 Medicine packaging film and preparation method thereof Pending CN111409344A (en)

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Application publication date: 20200714