CN111388487A - Application of glucosamine selenium in antivirus and immunity enhancement - Google Patents

Application of glucosamine selenium in antivirus and immunity enhancement Download PDF

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Publication number
CN111388487A
CN111388487A CN202010267450.2A CN202010267450A CN111388487A CN 111388487 A CN111388487 A CN 111388487A CN 202010267450 A CN202010267450 A CN 202010267450A CN 111388487 A CN111388487 A CN 111388487A
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CN
China
Prior art keywords
glucosamine
selenium
application
antivirus
immunity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202010267450.2A
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Chinese (zh)
Inventor
梁双林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jiangsu Shuanglin Marine Biological Pharmaceutical Co ltd
Original Assignee
Jiangsu Shuanglin Marine Biological Pharmaceutical Co ltd
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Publication date
Application filed by Jiangsu Shuanglin Marine Biological Pharmaceutical Co ltd filed Critical Jiangsu Shuanglin Marine Biological Pharmaceutical Co ltd
Priority to CN202010267450.2A priority Critical patent/CN111388487A/en
Publication of CN111388487A publication Critical patent/CN111388487A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses application of glucosamine selenium in resisting virus and enhancing immunity; the invention provides a new application of glucosamine selenium, and experiments prove that the glucosamine selenium has excellent antiviral and immunity enhancing properties.

Description

Application of glucosamine selenium in antivirus and immunity enhancement
Technical Field
The invention relates to application of glucosamine selenium.
Background
At present, glucosamine selenium is mainly used as a selenium supplement product, and the application of the glucosamine selenium is not further developed.
The existing antiviral and immunity enhancing medicines are many and are all in the fall.
Disclosure of Invention
The invention aims to provide application of glucosamine selenium in preparation of an antiviral and immunity-enhancing preparation.
The technical solution of the invention is as follows:
application of glucosamine selenium in preparing antiviral and immunity enhancing preparation is provided.
Laboratory preparation of selenium glucosamine
(1) Weighing 23g of sodium methoxide, and dissolving in 100ml of anhydrous methanol;
(2) weighing 30g of sodium selenite and dissolving in 100ml of anhydrous methanol;
(3) weighing 100g of glucosamine hydrochloride, dissolving the glucosamine hydrochloride in 600ml of methanol, adding the sodium methoxide solution obtained in the step (1), quickly stirring for 2min, and performing suction filtration to obtain mother liquor;
(4) adding the sodium selenite solution obtained in the step (2) into the mother liquor, adding a stirrer, reacting for 2 hours at 50 ℃, and cooling to normal temperature;
(5) freezing in refrigerator overnight;
(6) and taking out the refrigerating fluid from the refrigerator for suction filtration, drying the filter cake in a drying oven at 50 ℃, grinding and weighing to obtain 40g of glucosamine selenium.
The invention provides a new application of glucosamine selenium, and experiments prove that the glucosamine selenium has excellent antiviral and immunity enhancing properties.
The present invention will be further described with reference to the following examples.
Detailed Description
Application of glucosamine selenium in preparing antiviral and immunity enhancing preparation is provided.
Laboratory preparation of selenium glucosamine
(1) Weighing 23g of sodium methoxide, and dissolving in 100ml of anhydrous methanol;
(2) weighing 30g of sodium selenite and dissolving in 100ml of anhydrous methanol;
(3) weighing 100g of glucosamine hydrochloride, dissolving the glucosamine hydrochloride in 600ml of methanol, adding the sodium methoxide solution obtained in the step (1), quickly stirring for 2min, and performing suction filtration to obtain mother liquor;
(4) adding the sodium selenite solution obtained in the step (2) into the mother liquor, adding a stirrer, reacting for 2 hours at 50 ℃, and cooling to normal temperature;
(5) freezing in refrigerator overnight;
(6) and taking out the refrigerating fluid from the refrigerator for suction filtration, drying the filter cake in a drying oven at 50 ℃, grinding and weighing to obtain 40g of glucosamine selenium.

Claims (1)

1. Application of glucosamine selenium in preparing antiviral and immunity enhancing preparation is provided.
CN202010267450.2A 2020-04-08 2020-04-08 Application of glucosamine selenium in antivirus and immunity enhancement Pending CN111388487A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010267450.2A CN111388487A (en) 2020-04-08 2020-04-08 Application of glucosamine selenium in antivirus and immunity enhancement

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010267450.2A CN111388487A (en) 2020-04-08 2020-04-08 Application of glucosamine selenium in antivirus and immunity enhancement

Publications (1)

Publication Number Publication Date
CN111388487A true CN111388487A (en) 2020-07-10

Family

ID=71411330

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202010267450.2A Pending CN111388487A (en) 2020-04-08 2020-04-08 Application of glucosamine selenium in antivirus and immunity enhancement

Country Status (1)

Country Link
CN (1) CN111388487A (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101185642A (en) * 2007-06-22 2008-05-28 彭秀兰 Glucosamine lysine selenium salt and production process
CN103876158A (en) * 2013-11-18 2014-06-25 国家海洋局第三海洋研究所 Elemental selenium and sugar compound and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101185642A (en) * 2007-06-22 2008-05-28 彭秀兰 Glucosamine lysine selenium salt and production process
CN103876158A (en) * 2013-11-18 2014-06-25 国家海洋局第三海洋研究所 Elemental selenium and sugar compound and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
刘玥等: "DNS法测定D-氨基葡萄糖含量方法的研究", 《中国调味品》 *

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PB01 Publication
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SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20200710

RJ01 Rejection of invention patent application after publication