CN111388056A

CN111388056A - Bolt taking support with barbs arranged at cross positions of silk screens

Info

Publication number: CN111388056A
Application number: CN202010325335.6A
Authority: CN
Inventors: 王昂
Original assignee: Guangzhou Chuangjing Medical Technology Co ltd
Current assignee: Guangzhou Yijie Medical Technology Co ltd
Priority date: 2020-04-23
Filing date: 2020-04-23
Publication date: 2020-07-10

Abstract

The invention discloses a bolt taking support with barbs arranged at crossed positions of a silk screen, which belongs to the technical field of interventional therapy and comprises a mesh cage formed by cutting a nickel-titanium tube by laser and shaping at high temperature, wherein the mesh cage comprises a plurality of elastic wires, the elastic wires are mutually crossed to form a plurality of crossed end surface parts, barb units extending towards the inner side direction of an inner mesh cage are arranged on the crossed end surface parts, each barb unit is provided with a root part extending from the side, close to the far end, of the crossed end surface part, and each barb unit is provided with an inclined rod which is far away from the root part and extends towards the far end in an inclined mode. The invention has the advantages that the contact area of the thrombus taking bracket and the thrombus can be more reasonably increased, and the thrombus is prevented from sliding off; in addition, the tail end of the barb unit is additionally provided with a welded developing ring or developing block, so that the positioning developing effect of the bracket in the body can be enhanced.

Description

Bolt taking support with barbs arranged at cross positions of silk screens

Technical Field

The invention belongs to the field of interventional therapy instruments, and particularly relates to a thrombus removal support with barbs arranged at the crossed positions of a silk screen.

Background

Means for treating coronary and intracranial thrombosis generally require thrombolysis of the occluded area of the vessel with drugs or aspiration or capture of the thrombus in the occluded area with interventional procedures. The therapeutic device involved in capturing the thrombus comprises a micro catheter, a sheath, a guide wire, a thrombus removal support and the like. The thrombus taking bracket is the most key element for catching thrombus.

Embolectomy stents are generally mesh-shaped, formed by laser cutting a nickel titanium tube and shaping it at high temperature to form a mesh cage having a side near the distal end and a side near the proximal end. In order to avoid missing or falling down the thrombus fragment in the midway when catching the thrombus.

The following are a number of prior patents relating to the overall structure of the embolectomy device and the enhanced capturing effect added on the inner side of the embolectomy device: (1) CN201610013494.6 discloses a blood vessel thrombus taking device with a thorn-shaped structure and a thrombus therapeutic apparatus thereof, however, the thorn-shaped structure is not arranged at a more reasonable position in a net cage in the scheme, and the catching force is not enough or the blood vessel thrombus taking device is not conveniently hidden in a grid unit; (2) CN201810763392.5 discloses a thrombus extraction device, which has net rod units, can specifically capture hard thrombus and soft thrombus, and also enhances the capturing effect, however, there is no disclosure of a better form of the net rod units, and the positions of the net rod units arranged in the net cage are rarely disclosed; (3) CN201711466707.1 discloses a thrombus extractor having capturing rods for enhancing capturing effect on thrombus, any two of the capturing rods are different-surface rods, however, there is still no information about optimizing and improving the specific form of the capturing rods; (4) US20190216476A1 discloses an embolectomy stent and an improved structure thereof, wherein a developing block is arranged at a part of the middle of a net cage where a plurality of silk ribbons are intersected, and the structure can also better prevent thrombus fragments from being lost in a diseased blood vessel during catching.

Although some of the prior patents disclose more or less technical features for enhanced capture, none of the prior patents show a more reasonable capture of thrombus and also compromise the convenience of not deploying the embolectomy device and incorporating it into the microcatheter. Therefore, new solutions for realizing improvement are needed.

Disclosure of Invention

In order to solve the technical problems reflected by the background technology, the invention aims to provide a thrombus taking support with barbs arranged at the crossed positions of a silk screen, so as to increase the contact area of the thrombus taking support and thrombus more reasonably and avoid the thrombus from sliding off.

The specific scheme is as follows:

the support is tied in getting of silk screen crossing position barb, including a cylinder mould, the cylinder mould includes many elastic wires, elastic wire crosses each other, forms a plurality of terminal surface portions that cross, wherein, the terminal surface portion that cross all is equipped with the barb unit that the inboard direction of inside cylinder mould extends, the barb unit has the follow the terminal surface portion that crosses is close to the root that distal end one side extended, the barb unit has the down tube of keeping away from the root and extending to the slope of distal end direction, down tube top fixedly connected with develops the piece.

Further, the barb unit is in a fold line shape and is provided with two folding parts.

Further, the barb unit is serpentine and has two curved detours.

Furthermore, the mesh units of the mesh cage are parallelogram, and the length ratio of the first diagonal line and the second diagonal line of the parallelogram is 1: 1-1.5.

Further, the length of the barb units ranges from 0.5 to 0.75 times the value of the first diagonal length of the grid unit.

Further, the side of the netpen is open or closed.

Further, the surface of the mesh cage is covered with an outer coating containing an anticoagulant or antiplatelet agent.

Further, the cage is divided into a capturing section near the distal end for capturing thrombus and a diverging section near the proximal end, the diverging section having a diverging angle of 30 ° to 45 °.

Further, the length of the net cage is selected to be in a range of 10mm to 50mm, and the diameter of the net cage is selected to be in a range of 2mm to 5 mm.

Further, the number of barb units is a plurality of to, two axially adjacent barb units stagger the angular displacement of at least one grid unit, and two axially adjacent barb units stagger the axial displacement of at least one second diagonal length.

Compared with the prior art, the implementation of the invention has the beneficial effects that:

(1) the root of the barb unit protrudes from one side of the grid unit close to the near end to the far end, then gradually inclines inwards in the extending direction, and in order to facilitate the mesh cage before not being propped open, the barb unit is concealed in the micro-catheter, so that the extrusion force and the friction force of the micro-catheter to the mesh cage in an extrusion state are reduced. Moreover, the barb units are distributed in a mode of being mutually different in surface, and the extending length and the extending angle are reasonable, so that the capturing capacity of thrombus is improved, and thrombus omission is reduced.

(2) Because the net cage is made of the memory material, the net cage has a first shape which is extruded in the micro catheter and a second shape which is completely expanded and used for catching thrombus. The second shape is actually a shape formed by the memory of the embolectomy stent; when the cylinder mould is in the first form, the barb units can be hidden in the long and narrow gaps of the unit grids, so that the probability of increasing the overall thickness when the net mould is extruded and stacked is avoided, and the extrusion force and the friction force of the micro-catheter to the cylinder mould in the extrusion state are reduced. In other words, the present invention can be practiced without the need for larger diameter external microcatheters.

(4) The nickel-titanium tube is cut by laser, and the mesh cage formed by high-temperature shaping is adopted, the mesh cage is of an open-loop structure which can be bent to a certain degree to open and close, the diameter which can slightly change and is suitable for different positions in a blood vessel is facilitated, and the mesh cage can be collapsed and folded in the blood vessel under the condition of passing through the pressure and has self-expansion recovery capability under the free state, and has good wall-adhering property.

(5) The terminal fixedly connected with of barb develops the piece, can observe the bending condition of current cylinder mould more conveniently, is different from the mode that only set up development ring, development piece in the past at the cylinder mould near the one end of near-end and the one end that is close the distal end.

(6) Although the invention is mainly applied to clearing thrombus in blood vessels of cranium, brain and coronary vessels, the invention does not exclude the opportunity that the invention can be applied to other adaptive parts of human bodies.

Drawings

FIG. 1 is a perspective view of the netpen of the present invention;

fig. 2 is a schematic view of another perspective of the netpen of the present invention;

FIG. 3 is a schematic view of the cylinder mould of the present invention after it has been spread;

fig. 4A is a schematic representation (max) of the change in the crimp of the netpen in a preferred embodiment of the invention;

fig. 4B is a schematic representation of the variation in the degree of curling of the netpen in a preferred embodiment of the invention (moderate);

fig. 4C is a schematic representation (minimum) of the variation in the crimp of the netpen in a preferred embodiment of the invention;

FIG. 5A is a schematic view of the position relationship between a type of form barb elements and a grid of elements in a preferred embodiment of the present invention;

FIG. 5B is a schematic view of the position relationship between the barb elements and the cell lattice according to another preferred embodiment of the present invention;

FIG. 6A is a schematic representation of the use of the netpen of the present invention prior to passage through a region of thrombus occlusion;

fig. 6B is a schematic view of the use of the netpen of the present invention in its released state after passage through a thrombus-occluded area and capturing thrombus.

Fig. 7 is a schematic view showing the use state of the mesh cage of the present invention with the barb units concealed in the slits of the mesh units when the mesh cage is not spread and positioned in the microcatheter.

Wherein, 100, a net cage; 101. a grid cell; 110. an intersection end face portion; 111. a circular arc-shaped overlapping structure; 112. drawing wires; 113. a first edge portion; 114. a second edge portion; 115. capturing and segmenting; 116. divergent segmentation; 117. dislocation distance; 118. a projection; 119. an inner concave portion; 200. a barb unit; 201. a developing block; 300. an outer catheter; 301. a microcatheter; 400. a blood vessel; 401. thrombosis.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail below with reference to the accompanying drawings, embodiments and modifications. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

To describe the structure of the modified flexible guidewire more clearly, the terms "distal" and "proximal" are defined herein as being used as terms commonly used in the field of interventional medical devices. Specifically, "distal" refers to the end of the procedure distal to the operator, and "proximal" refers to the end of the procedure proximal to the operator. Of course, for a single device object, the "proximal" end may also be defined as the end thereof closer to the operator, and the "distal" end may also be defined as the end thereof further from the operator. In the present invention, the expressions "distal direction" and "proximal direction" are used only for the sake of reference. In the invention, the end close to the far end is only used for describing one end face or end point of the device object far away from an operator; the term "end near the proximal end" is used only to describe one end face or point of the device object near the operator.

In addition, for convenience of describing individuals such as each part and component, the present invention will be described using descriptions indicating positional relationships such as "left", "right", "front", "rear", "upper", "lower", and the like; in the present invention, the description with the serial numbers such as "first" and "second" is only used to distinguish the objects of description in principle, and does not refer to any meaning of importance distinction or arrangement distinction.

Referring to fig. 1 to 7, a mesh cross-position barbed embolectomy stent comprises a mesh cage 100 formed by laser cutting a nickel titanium tube and performing high-temperature setting, wherein the mesh cage 100 is substantially cylindrical, and has a base circle defining a reference winding aperture size and an axis. This is described in some of the prior patents mentioned in the background, and will not be described in detail here.

Netpen 100 can include many elastic wires, the elastic wire crosses each other, forms a plurality of end portions 110 that cross, end portion 110 that cross all is equipped with barb unit 200 to the inboard direction extension of netpen 100, barb unit 200 has the follow end portion 110 that crosses is close to the root that distal end one side extended, barb unit 200 has the down tube of keeping away from the root and extending to distal end direction slope.

As shown in fig. 3, the mesh cage may preferably have a parallelogram shape with a first diagonal line having a longer length and a second diagonal line having a shorter length, as the mesh unit 101. The length of the barb cells 200 may range from 0.5 to 0.75 times the value of the first diagonal length of the grid cells 101. The number of barb units 200 provided in the netpen 100 is plural, and two axially adjacent barb units 200 should be offset by an angular displacement of at least one grid unit 101, and two axially adjacent netpens 100 should be offset by an axial displacement of at least one first diagonal length. In this manner, a plurality of barb units 200 of different faces may be formed. Further improving the effect of grasping the thrombus.

In addition, as a preferred embodiment, the first edge portion 113 and the second edge portion 114 have a misalignment distance 117 in the axial direction of the netpen 100. Further, a convex portion 118 and a concave portion 119 which are complementary in shape and convex are provided between the first edge portion 113 and the second edge portion 114.

As shown in fig. 5A, 5B, and 7, in order to observe the bending of the netpen 100, as a preferred scheme, a developing block 201 may be fixedly connected to the top end of the inclined rod, and the developing block 201 may be made of a material that is easily developed under X-rays, such as gold, platinum iridium, platinum tantalum, and the like. By such design, a plurality of developing modes axially arranged around the winding axis of the cylinder mould 100 can be formed, so that an operator can know the bending condition of the cylinder mould 100 at present more clearly.

As shown in fig. 5A, as a modification, the barb unit 200 is folded and has two folded portions, which is advantageous for the barb unit 200 to be hidden in the mesh unit 101 when the mesh cage 100 is not yet moved out of the micro duct 301 outside the mesh cage, and as shown in fig. 7, the barb unit 200 is hidden in the mesh unit 101 which is then in a long and narrow shape, so that the possibility of increasing the overall thickness when the mesh cage 100 is pressed and stacked can be avoided, and the pressing force and the friction force of the micro duct 301 to the mesh cage 100 in the pressed state can be reduced. In addition, because barb unit 200 has two portions of bending to the end of barb unit 200 is to distal end extension, so, even when the barb unit 200 end of accidental probably protrusion in cylinder mould 100 periphery, rub the vascular wall, can not cause the scratch yet.

As a modified example, as shown in fig. 5B, the barb unit 200 has a serpentine shape and two curved detours; similarly, the opportunity for increased overall thickness during extrusion stacking is avoided, thereby reducing the concern of extrusion and friction of microcatheter 301 against cage 100 in an extruded state. And the end of barb unit 200 is the distal end extension that is, even if the terminal probably protrusion in cylinder mould 100 periphery of barb unit 200 that happens, rub the vascular wall, can not cause the scratch.

As a preferred embodiment, the netpen has the grid unit 101 in a diamond shape, and the length ratio of a first diagonal line and a second diagonal line of the diamond shape is 1:1 to 1.5.

In particular, the netpen 100 may be a closed-loop structure, without gaps on the sides; of course, it may be the scheme as shown in fig. 3, fig. 4A, fig. 4B, and fig. 4C, the lateral surface of the netpen 100 is an open structure, i.e. an open ring structure, and the lateral surface is provided with an axially extending slit, so as to allow the netpen 100 to be bent and expanded to some extent, which is beneficial for adapting to slightly varying diameters of different positions in the blood vessel 400, and the netpen 100 can collapse and fold under pressure in the blood vessel 400 and has self-expansion and recovery capability in a free state, and has good adherence properties. As shown in fig. 4A, 4B and 4C, the arc-shaped overlapping structure 111 is actually present to adapt to the change of the vessel diameter of the blood vessel 400. Referring to fig. 3, for the convenience of understanding, the netpen 100 is unfolded and then, as shown in fig. 3, the first edge portion 113 and the second edge portion 114 are overlapped to form a circular arc-shaped overlapping structure 111. As a preferred embodiment, the surface of the netpen 100 is covered with an outer coating containing an anticoagulant or antiplatelet agent.

As shown in fig. 3, the netpen 100 is divided into a catching section 115 near the distal end for catching thrombus 401, and a diverging section 116 near the proximal end, the diverging section 116 having a diverging angle of 30 ° to 45 °. The side of the diverging section 116 near the proximal end is attached to a pull wire 112.

Preferably, the length of the netpen 100 is selected in the range of 10mm to 50mm, and the diameter of the netpen 100 is selected in the range of 2mm to 5 mm. Of course, such dimensions are provided for a person skilled in the art as a practical reference.

Referring to fig. 6A, the thrombus-removal stent with barbs at the crossing positions of the silk screen is hidden in an external microcatheter 301 and is not in a spread state in operation. Referring to fig. 6B again, the thrombus-retrieval stent provided with barbs at the crossing positions of the silk screen according to the present invention is in a use state of catching the thrombus 401. Finally, the embolectomy support with barbs at the crossed positions of the silk screen is required to be arranged in a therapeutic instrument and matched with other modules and/or parts for use during operation. Accordingly, the therapeutic apparatus should include, but not be limited to: the outer catheter 300, the hemostatic valve device, the sheath, the microcatheter 301, the pull wire 112, and the thrombectomy stent itself. The overall structure of the medical instrument is well known and does not form the invention of the present invention, and therefore, the present invention is not described in detail.

Finally, although the invention is mainly applied to the removal of thrombus in blood vessels of cranium, brain and coronary vessels, the invention does not exclude the opportunity that the invention can be applied to other adaptive parts of human bodies.

The above description is only for the purpose of illustrating preferred embodiments and variations of the present invention, and is not to be construed as limiting the invention, as any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The bolt support of getting that silk screen crossing position set up the barb, including a cylinder mould, the cylinder mould includes many elastic wires, elastic wire intersects each other, forms a plurality of end face portions that intersect, its characterized in that: the terminal surface portion that intersects all is equipped with the barb unit that the inboard direction of inside cylinder mould extends, the barb unit has the follow the terminal surface portion that intersects is close to the root that distal end one side extended, the barb unit has the down tube of keeping away from the root and extending to distal end direction slope, down tube top fixedly connected with develops the piece.

2. The cross-position barbed bolt removal bracket according to claim 1, wherein: the barb unit is in a fold line shape and is provided with two folding parts.

3. The cross-position barbed bolt removal bracket according to claim 1, wherein: the barb unit is serpentine and has two curved returns.

4. The cross-position barbed bolt removal bracket according to claim 1, wherein: the mesh units of the mesh cage are parallelogram, and the length ratio of a first diagonal line to a second diagonal line of the parallelogram is 1: 1-1.5.

5. The cross-position barbed bolt removal bracket according to claim 4, wherein: the length of the barb units ranges from 0.5 to 0.75 times the value of the first diagonal length of the grid unit.

6. The cross-position barbed bolt removal bracket according to claim 1, wherein: the side of the net cage is open or closed.

7. The cross-position barbed bolt removal bracket according to claim 1, wherein: the surface of the net cage is covered with an outer coating containing anticoagulant or antiplatelet agent.

8. The cross-position barbed bolt removal bracket according to claim 1, wherein: the cage is divided into a capturing section near the distal end for capturing thrombus and a diverging section near the proximal end, the diverging section having a divergence angle of 30 ° to 45 °.

9. The cross-position barbed bolt removal bracket according to claim 1, wherein: the length selection range of the net cage is 10mm to 50mm, and the diameter selection range of the net cage is 2mm to 5 mm.

10. The cross-position barbed bolt removal bracket according to claim 4, wherein: the quantity of barb unit is a plurality of to, two barb units that axially adjacent stagger the angular displacement of at least one grid cell, two barb units that axially adjacent are staggering the axial displacement of at least one second diagonal length.