CN111359004A - Polyurethane foam dressing with antibacterial property - Google Patents
Polyurethane foam dressing with antibacterial property Download PDFInfo
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- CN111359004A CN111359004A CN201811587969.8A CN201811587969A CN111359004A CN 111359004 A CN111359004 A CN 111359004A CN 201811587969 A CN201811587969 A CN 201811587969A CN 111359004 A CN111359004 A CN 111359004A
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- polyurethane foam
- foam dressing
- antibacterial
- dressing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polyurethanes Or Polyureas (AREA)
Abstract
The invention discloses an antibacterial polyurethane foam dressing, belongs to the technical field of composite materials, and solves the technical problem that the existing dressing is too large in pore and not beneficial to shielding bacteria. The polyurethane foam dressing with antibacterial property provided by the invention comprises the following components in parts by weight: 60-65 parts of waterborne polyurethane prepolymer, 2.5-3 parts of catalyst, 7-9 parts of surfactant, 30-40 parts of isocyanate, 0.5-2 parts of anti-yellowing agent and 2-4 parts of hollow silver-loaded polyester staple fiber. According to the invention, the hollow silver-loaded polyester short fibers are uniformly dispersed in the soft polyurethane foam to obtain the polyurethane foam dressing with antibacterial property, so that excessive moisture loss caused by macropore is prevented, and the shielding effect of the foam dressing on bacteria is enhanced.
Description
Technical Field
The invention relates to the technical field of high polymer materials, in particular to an antibacterial polyurethane foam dressing.
Background
Polyurethane (PU) is a generic name for a class of high molecular polymers whose main chain contains urethane (-NHCOO-) units, and is a multiblock copolymer formed by stepwise addition condensation of a polyol, a polyisocyanate, and a small-molecule chain extender. A large number of animal experiments and acute and chronic toxicity experiments prove that the medical polyurethane is non-toxic, non-antigenic, physiologically inert and has good blood and tissue compatibility, so that the medical polyurethane has wide application in the field of wound dressings.
The foam type medical dressing has a porous structure, is almost completely transparent to oxygen and carbon dioxide, has strong water absorption capacity, maintains a moderate moist environment of a wound surface mainly through absorption of a foam structure on exudates and water vapor transfer, and is suitable for wounds with a large amount of exudates in II-degree burn and scald wound surfaces, ulcer wound surfaces and the like. At present, the foam medical dressing taking polyurethane and polyvinyl alcohol as base materials is used more in clinic, has good plasticity and adjustable thickness, can better protect wounds, can effectively promote the healing of the wounds when used in a mixed medicine manner, and can better relieve the pain of patients. However, the pores of the foam dressing are generally large, granulation tissue of the wound surface easily grows into the pores when the foam dressing is applied for a long time, pain is caused when the dressing is replaced, new tissue is damaged, and the overlarge pores are not beneficial to shielding bacteria.
Disclosure of Invention
The invention provides the polyurethane foam dressing with antibacterial property in order to prevent excessive moisture loss caused by macroporosity and enhance the shielding effect of the foam dressing on bacteria.
In order to achieve the above purpose, the invention provides the following technical scheme:
a polyurethane foam dressing with antibacterial property comprises the following components in parts by weight:
60-65 parts of waterborne polyurethane prepolymer, 2.5-3 parts of catalyst, 7-9 parts of surfactant, 30-40 parts of isocyanate, 0.5-2 parts of anti-yellowing agent and 2-4 parts of hollow silver-loaded polyester staple fiber.
Preferably, the aqueous polyurethane prepolymer is polyester polyol or polyether polyol.
Preferably, the length of the hollow silver-loaded polyester staple fiber is 1-3 mm.
Preferably, the catalyst is triethanolamine or DMEA.
Preferably the surfactant is sodium lauryl sulphate.
The preparation method of the polyurethane foam dressing with antibacterial property comprises the following steps: respectively weighing the waterborne polyurethane prepolymer, the catalyst, the surfactant, the isocyanate and the anti-yellowing agent in parts by weight, heating to 26-28 ℃, mixing and stirring at a stirring speed of 600-1200 rpm for 25-30 s, quickly pouring the mixture into a foaming mold at a temperature of 50-70 ℃ for foaming and molding, placing the molded mixture into an oven for curing for 50-60 min, taking out the molded mixture, placing the molded mixture at room temperature for 24h to obtain soft polyurethane foam, and uniformly dispersing the hollow silver-loaded polyester short fibers in the soft polyurethane foam to obtain the polyurethane foam dressing with antibacterial property.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the hollow silver-loaded polyester short fibers are uniformly dispersed in the soft polyurethane foam to obtain the polyurethane foam dressing with antibacterial property, so that excessive moisture loss caused by macropore is prevented, and the shielding effect of the foam dressing on bacteria is enhanced. The action principle is as follows: the cell walls and cell membranes of most bacteria have anionic groups such as phosphate groups, so that the cell walls and cell membranes have negative charges, and silver ions have positive charges, so that charge neutralization reaction can be generated when the silver ions contact the bacteria, and normal physiological activities of the bacteria are hindered; the silver example can also block the electron transmission in bacteria, increase the DNA stability of the bacteria so as to weaken the cell replication of the bacteria, and the negative charges of cell walls and cell membranes are unevenly distributed to cause deformation under the action of the external force of an electric field, so that the bacteria are physically cracked and die due to the cracking phenomenon; on the other hand, the silver ions can make the 6-phosphomannose isomerase lose activity by combining with the cysteine in the protein, and because the 6-phosphomannose isomerase plays an important role in the cell wall synthesis process of the bacteria, the damage of the 6-phosphomannose isomerase can cause the phosphate, the glutamine and other important nutrients in the cells to be lost, thereby destroying the propagation of the bacteria cells; in addition, silver ions can activate oxygen in the surrounding air or water under the action of light, so that hydroxyl radicals and active oxygen ions are generated, and the two ions can destroy the proliferation of microbial cells and even kill the cells.
Detailed Description
In order to make those skilled in the art better understand the technical solution of the present invention, the present invention will be further described in detail with reference to the following embodiments. The materials specifically mentioned are all commercially available products.
Example 1
Respectively weighing 60 parts by weight of polyester polyol, 2.5 parts by weight of triethanolamine, 7 parts by weight of sodium lauryl sulfate, 30 parts by weight of isocyanate and 0.5 part by weight of anti-yellowing agent, heating to 26 ℃, mixing and stirring for 30s at the stirring speed of 600 revolutions per minute, quickly pouring the mixture into a foaming mold at the temperature of 50 ℃ for foaming and molding, placing the mixture into an oven for curing for 60min after molding, taking out and placing at room temperature for 24h to obtain soft polyurethane foam, and uniformly dispersing the hollow silver-loaded polyester short fibers with the length of 1mm in the soft polyurethane foam to obtain the antibacterial polyurethane foam dressing.
Example 2
Respectively weighing 63 parts of polyether polyol, 2.8 parts of triethanolamine, 8 parts of sodium lauryl sulfate, 35 parts of isocyanate and 1 part of anti-yellowing agent according to the parts by weight, heating to 27 ℃, mixing and stirring at the stirring speed of 900 revolutions per minute for 28s, quickly pouring the mixture into a foaming mold with the temperature of 60 ℃ for foaming and molding, placing the mixture into an oven for curing for 55min after molding, taking out the mixture and placing the mixture at room temperature for 24h to obtain soft polyurethane foam, and uniformly dispersing the hollow silver-loaded polyester short fibers with the length of 2mm in the soft polyurethane foam to obtain the polyurethane foam dressing with the antibacterial property.
Example 3
Respectively weighing 65 parts by weight of polyether polyol, 3 parts by weight of DMEA, 9 parts by weight of sodium lauryl sulfate, 40 parts by weight of isocyanate and 2 parts by weight of anti-yellowing agent, heating to 28 ℃, mixing and stirring at the stirring speed of 1200 r/min for 25s, quickly pouring the mixture into a foaming mold at the temperature of 70 ℃ for foaming and molding, placing the molded mixture into an oven for curing for 50min, taking out the cured mixture and placing the cured mixture at room temperature for 24h to obtain soft polyurethane foam, and uniformly dispersing the hollow silver-loaded polyester short fibers with the length of 3mm in the soft polyurethane foam to obtain the antibacterial polyurethane foam dressing.
Performance testing
(1) Taking the polyurethane foam dressing with antibacterial property prepared in the examples 1-3, wherein the size of each sample is 100mm (length) × 50mm (width) × 5mm (height), observing the size and distribution of pore diameters by adopting a JSM-5600LV type scanning electron microscope, calculating the length represented by each pixel in a scanning electron microscope image by using image processing software, performing Gaussian smoothing on each electron microscope photo, removing noise in the image, performing edge detection on the smoothed image to determine pores in the image, performing binarization processing on the image, extracting the image of the pores in each image, and calculating the diameter of each equivalent circle of the pores and the diameter distribution of the sample by using a computer.
(2) Shooting the surface morphology of each sample by using a Scanning Electron Microscope (SEM), and calculating the aperture ratio, wherein the calculation formula is as follows:
p＝(Nopen+1/2Npart)/(Nopen+Npart+Npin+Nclosed)
in the formula:
p is the opening rate;
Nopenthe number of cells in a completely open-cell structure;
Npartthe number of cells that are partially open;
Npinthe number of pinhole-like cells;
Nclosedthe number of cells in a closed cell structure;
(3) YG461E digital air permeameter, according to the standard GB/T5453-1997 determination of air permeability of textile fabrics.
(4) And (3) carrying out qualitative antibacterial performance test on the prepared medical foam dressing by adopting an antibacterial ring method and a flask oscillation method, and further evaluating the antibacterial effect of the sample.
The results are shown in Table 1.
TABLE 1 Performance test results of the antibacterial polyurethane foam dressings prepared in examples 1 to 3
| Item | Example 1 | Example 2 | Example 3 |
| Pore size (. mu.m) and distribution | 90.23, uniform distribution | 89.36, uniform distribution | 89.67, uniform distribution |
| Percentage of open area (%) | 83.3 | 85.6 | 84.1 |
| Air permeability (mm/s) | 1326 | 1365 | 1349 |
| Bacteriostatic activity | Sterile growth | Sterile growth | Sterile growth |
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: it is to be understood that modifications may be made to the technical solutions described in the foregoing embodiments, or equivalents may be substituted for some of the technical features thereof, but such modifications or substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (6)
1. The polyurethane foam dressing with the antibacterial property is characterized by comprising the following components in parts by weight:
60-65 parts of waterborne polyurethane prepolymer, 2.5-3 parts of catalyst, 7-9 parts of surfactant, 30-40 parts of isocyanate, 0.5-2 parts of anti-yellowing agent and 2-4 parts of hollow silver-loaded polyester staple fiber.
2. The antibacterial polyurethane foam dressing as claimed in claim 1, wherein the aqueous polyurethane prepolymer is polyester polyol or polyether polyol.
3. The antibacterial polyurethane foam dressing as claimed in claim 1, wherein the length of the hollow silver-loaded polyester staple fiber is 1 to 3 mm.
4. The polyurethane foam dressing having antibacterial properties as claimed in claim 1, wherein the catalyst is triethanolamine or DMEA.
5. The polyurethane foam dressing having antibacterial properties according to claim 1, characterized in that the surfactant is sodium lauryl sulfate.
6. The polyurethane foam dressing having antibacterial property according to any one of claims 1 to 5, characterized in that the preparation method thereof comprises the steps of: respectively weighing the waterborne polyurethane prepolymer, the catalyst, the surfactant, the isocyanate and the anti-yellowing agent in parts by weight, heating to 26-28 ℃, mixing and stirring at a stirring speed of 600-1200 rpm for 25-30 s, quickly pouring the mixture into a foaming mold at a temperature of 50-70 ℃ for foaming and molding, placing the molded mixture into an oven for curing for 50-60 min, taking out the molded mixture, placing the molded mixture at room temperature for 24h to obtain soft polyurethane foam, and uniformly dispersing the hollow silver-loaded polyester short fibers in the soft polyurethane foam to obtain the polyurethane foam dressing with antibacterial property.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811587969.8A CN111359004A (en) | 2018-12-25 | 2018-12-25 | Polyurethane foam dressing with antibacterial property |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811587969.8A CN111359004A (en) | 2018-12-25 | 2018-12-25 | Polyurethane foam dressing with antibacterial property |
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| Publication Number | Publication Date |
|---|---|
| CN111359004A true CN111359004A (en) | 2020-07-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811587969.8A Pending CN111359004A (en) | 2018-12-25 | 2018-12-25 | Polyurethane foam dressing with antibacterial property |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023123879A1 (en) * | 2021-12-31 | 2023-07-06 | 泰州市榕兴医疗用品股份有限公司 | Antibacterial polyurethane sponge and preparation method therefor |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1849464A1 (en) * | 2006-04-28 | 2007-10-31 | Advanced Medical Solutions Limited | Wound dressings |
| DE102008062824A1 (en) * | 2008-12-23 | 2010-07-01 | Paul Hartmann Ag | wound dressing |
| CN104225665A (en) * | 2014-09-30 | 2014-12-24 | 南阳市汇博生物技术有限公司 | Organic polyurethane foam dressing and preparation method thereof |
| CN108079362A (en) * | 2017-12-29 | 2018-05-29 | 广州润虹医药科技股份有限公司 | A kind of polyurethane foam dressing and preparation method thereof |
-
2018
- 2018-12-25 CN CN201811587969.8A patent/CN111359004A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1849464A1 (en) * | 2006-04-28 | 2007-10-31 | Advanced Medical Solutions Limited | Wound dressings |
| DE102008062824A1 (en) * | 2008-12-23 | 2010-07-01 | Paul Hartmann Ag | wound dressing |
| CN104225665A (en) * | 2014-09-30 | 2014-12-24 | 南阳市汇博生物技术有限公司 | Organic polyurethane foam dressing and preparation method thereof |
| CN108079362A (en) * | 2017-12-29 | 2018-05-29 | 广州润虹医药科技股份有限公司 | A kind of polyurethane foam dressing and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023123879A1 (en) * | 2021-12-31 | 2023-07-06 | 泰州市榕兴医疗用品股份有限公司 | Antibacterial polyurethane sponge and preparation method therefor |
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