CN111358842A - Medicine for treating damp-heat jaundice and blood stasis amenorrhea and preparation method thereof - Google Patents
Medicine for treating damp-heat jaundice and blood stasis amenorrhea and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicines, and discloses a medicine for treating damp-heat jaundice and blood stasis amenorrhea and a preparation method thereof, wherein the medicine for treating damp-heat jaundice and blood stasis amenorrhea consists of 450g of rheum officinale according to the mass. The preparation method of the medicine for treating damp-heat jaundice and amenorrhea due to blood stasis comprises the following steps: selecting rhubarb, and performing sorting and drying treatment to obtain dry rhubarb without impurities for later use; grinding radix et rhizoma Rhei into fine powder, mixing, and sieving to obtain radix et rhizoma Rhei powder; the rhubarb powder is filled into capsules, and 1000 granules with 0.4g of each granule are prepared, thus obtaining the medicine for treating damp-heat jaundice and amenorrhea due to blood stasis. The invention has the effects of purging heat and promoting bowel movement, cooling blood and removing toxicity, and removing blood stasis and dysmenorrhea, and is used for excess heat constipation, stagnation abdominal pain, damp-heat jaundice, blood stasis amenorrhea and the like. The rhubarb is bitter in taste and cold in nature, has the functions of promoting liver cell regeneration, reducing immunoreaction, eliminating immune complex and regulating immunity in treating liver diseases, and can stimulate the organism to produce interferon and improve the antiviral capacity of the organism.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a medicine for treating damp-heat jaundice and blood stasis amenorrhea and a preparation method thereof.
Background
Currently, the current state of the art commonly used in the industry is such that: with the development of society and the progress of science and technology, people are attracted by various electronic products and the like, and the resistance of the body is reduced and the people are easily affected by damp evil due to serious bad living habits, poor sleeping quality, insufficient sleeping and the like; in addition, season changes, high working pressure, improper diet and the like can also cause damp-heat jaundice, excessive heat constipation, stagnation and abdominal pain; in addition, women are easy to have blood stasis amenorrhea due to irregular diet, weight loss, insufficient sleep, high working pressure and the like; therefore, the symptoms are effectively changed, and a medicine with the effects of purging heat and promoting bowel movement, cooling blood and removing toxicity, and removing blood stasis and dysmenorrhea is urgently needed.
In summary, the problems of the prior art are as follows: (1) icteric hepatitis is common clinically, cell death and liver injury can be aggravated due to overhigh bilirubin in blood of a patient, and a specific treatment method for viral hepatitis hyperbilirubinemia, particularly severe hepatitis and acute and chronic hepatitis combined cholestasis is lacked at present.
(2) The icteric hepatitis always has damp-heat as the primary cause at the beginning, and the heat as the primary cause and the dampness as the secondary cause in the icteric hepatitis, but generally has the effect of removing dampness by diuresis in treatment, and cannot treat the primary cause.
(3) After a patient with stroke and constipation has constipation, because excrement stays in the body for too long time, bacteria in intestinal tracts are decomposed, fermented and putrefactive, so that the patient generates toxins, symptoms such as headache, dizziness, inappetence, abdominal distension and pain, difficult defecation, dysphoria and the like are caused, the life quality and the prognosis of the patient are seriously affected, the patient can have excessive defecation with excessive force, the blood pressure or the intracranial pressure of the patient can be increased in a reflective manner, and further acute left heart failure or even cerebral hernia is induced, and the life of the patient is threatened.
The difficulty and significance for solving the technical problems are as follows: (1) according to the traditional Chinese medicine, jaundice is caused by damp-heat retention and steaming, damp obstruction and heat transformation, and heat toxin forces bile to overflow. Radix et rhizoma Rhei is bitter and cold in nature, has heavy and turbid smell, and has effects of removing pathogenic accumulation, relieving constipation, clearing pathogenic fire, cooling blood, promoting blood circulation, relieving fatigue, promoting bile flow, eliminating jaundice, and clearing away damp-heat. Modern experiments prove that the rhubarb can improve microcirculation, increase hepatic blood flow, promote gallbladder contraction, relax common bile duct sphincter, dredge capillary bile ducts, and has the functions of immunoregulation, stabilizing the internal environment of an organism, repairing liver cells and the like.
(2) Abdominal distension caused by enteroscopy needs to pay attention to uncomfortable symptoms such as abdominal distension after colonoscopy, which are generally considered as normal phenomena and are easy to ignore, the abdominal distension is considered to be good after a period of time, and indifferent attitudes are often adopted, so that discomfort is brought to the mind and body of a patient, and unnecessary medical disputes are possibly caused. In the past, methods such as anal canal ventilation, abdomen massage or glycerin enema are adopted, and although the effects are certain, the relieving time is prolonged. Abdominal distension caused by enteroscopy adopts an anal tube exhausting method, and the effect is achieved only by inserting the anal tube into the anus to continuously exhaust, so that inconvenience is brought to the daily life of a patient; the enema of the glycerin enema is used reversely, the anus or the rectal mucosa is easy to be damaged, the pain of a patient is increased, the heating is needed in winter, the cold stimulation is avoided, and the workload of nursing staff and family members is increased. Enema with glycerin enema can aggravate the condition if enteroscopy is complicated by intestinal perforation. Enema should not be used for patients with severe gravity insufficiency.
(3) Acute pancreatitis is a common acute abdominal disease in clinic, the acute pancreatitis is acute in onset, serious in illness, high in complications and mortality rate, multiple organ failure and death can be caused if the acute pancreatitis is not treated in time, and the life safety of a patient is seriously affected. In recent years, many studies have pointed out that inflammatory reactions occurring locally in the pancreas play an important role in the onset of acute pancreatitis, and that control of inflammatory factors in vivo is of positive significance in ameliorating the state of an illness. In the current western medicine treatment, fasting, gastrointestinal decompression and antibiotic use are mainly adopted, but the obtained effect is not very obvious, and with the continuous development of the traditional Chinese medicine, the traditional Chinese medicine treatment is gradually and widely applied to acute pancreatitis.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a medicine for treating damp-heat jaundice and blood stasis amenorrhea and a preparation method thereof.
The invention is realized in such a way that the medicine for treating damp-heat jaundice and blood stasis amenorrhea consists of 450g of rhubarb according to the mass.
The invention also aims to provide a preparation method of the medicine for treating damp-heat jaundice and amenorrhea due to blood stasis, which comprises the following steps:
the method comprises the following steps: selecting radix et rhizoma Rhei, cleaning, and oven drying to obtain dried radix et rhizoma Rhei;
step two: grinding rhubarb into fine powder, drying in a constant-temperature drying oven in a clean workshop, sieving, and uniformly mixing through a three-dimensional mixer to obtain rhubarb powder 1;
step three: the rhubarb powder 1 is filled into capsules by a full-automatic capsule filling machine to prepare 1000 granules, thus obtaining the medicine for treating damp-heat jaundice and blood stasis amenorrhea.
And further, drying the mixture in a constant-temperature drying oven at 60 ℃ for 2 hours in a clean workshop, and sieving the dried mixture by using a 120-mesh sieve.
And further, in the third step, the rhubarb powder 1 is filled into capsules by a full-automatic capsule filling machine to prepare 1000 capsules.
Furthermore, each particle in the third step contains 0.4g of rhubarb powder.
The invention also aims to provide a capsule prepared from the medicine for treating damp-heat jaundice and blood stasis amenorrhea.
The Chinese medicine composition has the advantages that the Chinese medicine composition has the effects of purging heat, dredging intestines, cooling blood, removing toxin, removing blood stasis and dysmenorrhea, is used for excess heat constipation, accumulated abdominal pain, damp-heat jaundice, blood stasis amenorrhea and the like, is bitter in taste and cold in nature, has the effects of purging, eliminating stagnation, clearing heat, removing toxin, activating blood and removing stasis, has wide main pharmacological effects of ① cholagogue, promoting bile secretion, increasing bile excretion, dredging liver capillary bile ducts, eliminating liver cell inflammation and promoting liver cell regeneration, ② hepatoprotective effect, can obviously reduce ALT activity of liver injury rats caused by carbon tetrachloride in serum, reduce liver cell degeneration and necrosis, stimulate large intestine mucosa to reflectively enhance large intestine peristalsis to drain, enable pathogens, toxins, various intestinal toxic substances and body metabolites to be discharged out of the body, and ③ has the effects of regulating immunity and antivirus, inhibiting body fluid, enhancing cellular immune function, reducing immune response, eliminating immune complexes, and stimulating immune interference of organisms, and further has the function of stimulating immunity to generate antivirus.
Drawings
Fig. 1 is a flowchart of a preparation method of a medicine for treating damp-heat jaundice and amenorrhea due to blood stasis according to an embodiment of the invention.
Fig. 2 is a schematic diagram of a preparation method of the medicine for treating damp-heat jaundice and amenorrhea due to blood stasis provided by the embodiment of the invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The medicine for treating damp-heat jaundice and blood stasis amenorrhea provided by the embodiment of the invention consists of 450g of rheum officinale.
The application principle of the present invention will be described in detail with reference to the accompanying drawings;
as shown in fig. 1, the preparation method of the medicine for treating damp-heat jaundice and amenorrhea due to blood stasis provided by the embodiment of the invention comprises the following steps:
s101: selecting rhubarb, and performing sorting and drying treatment to obtain dry rhubarb without impurities for later use;
s102: grinding radix et rhizoma Rhei into fine powder, drying at constant temperature in a clean workshop in a drying oven at 60 deg.C for 2 hr, mixing, and sieving with 120 mesh sieve to obtain radix et rhizoma Rhei powder;
s103: the rhubarb powder is filled into capsules and prepared into 1000 granules, thus obtaining the medicine for treating damp-heat jaundice and amenorrhea due to blood stasis.
In step S103, each grain provided in the embodiment of the present invention is 0.4 g.
Icteric hepatitis is common clinically, and cell death and liver injury are aggravated due to high bilirubin in blood of a patient. The hyperbilirubinemia can cause extensive silt-like calculus and biliary cirrhosis in the liver until the liver cells are liquefied or coagulated and necrotized. At present, no specific treatment method is available for treating viral hepatitis hyperbilirubinemia, especially severe hepatitis and acute and chronic hepatitis combined with cholestasis. 31 cases of treatment with rhubarb powder in 5 months to 5 months in 2017 in the hospital are reported as follows.
1, 31 cases of clinical data are all inpatients in 5 months to 5 months in 2017, and the diagnosis refers to the diagnosis standard of viral hepatitis prevention and treatment scheme revised by the Chinese medical society infectious disease and parasitic disease subcontract and the liver disease subcontract in combination. The obstructive jaundice inside and outside the liver is eliminated through the imaging examination.
Randomly dividing into two groups, wherein the treatment group comprises 31 male 21 and 7 female, the age is 20-65 years, and the average age is 40 years; the control group comprises 30 male 22 female 8, the age is 20-67 years, and the average age is 40 years. The sex, age, main symptoms, signs and laboratory test results of the two groups of cases are all comparable.
2 method of treatment
The treatment group is added with 4-6 rhubarb powder capsules on the basis of comprehensive treatment and is taken with warm boiled water, the dosage of the rhubarb powder capsules can be determined according to the physical condition of a patient, 2-4 times of defecation is preferably kept every day, and the control group adopts comprehensive treatment.
3 therapeutic results
3.1 curative effect standard is significant: the subjective symptoms disappear, and the serum bilirubin and transaminase are reduced to normal or close to normal; the method has the following advantages: the subjective symptoms are improved, and the serum bilirubin and transaminase are reduced by more than 50 percent before treatment; and the above standard is not met.
3.2 results the treatment group showed 19 cases, 8 cases, 4 cases, the effect showed 61.2%, the total effective rate was 87%, the control group showed 11 cases, 8 cases, 11 cases, 36.6% and 63.3%, respectively, i2 ═ 4.01, 5.02, P was < 0.05. Liver function changes before and after treatment in both groups are shown in Table 1.
The main pharmacological actions include ① cholagogic action, the rhubarb has the functions of promoting bile secretion, increasing bile excretion, dredging liver capillary bile duct, eliminating liver cell inflammation and promoting liver cell regeneration, ② hepatoprotective action, the rhubarb can obviously reduce ALT activity of rat serum with liver injury caused by carbon tetrachloride, reduce liver cell degeneration and necrosis, stimulate large intestine mucosa reflexively to enhance large intestine peristalsis to guide diarrhea and discharge pathogens, toxins, various enterogenous toxic substances and body metabolites out of the body, and ③ regulates immunity and antiviral action, the rhubarb can inhibit humoral immunity, enhance cellular immunity function, reduce immunoreaction, eliminate immune complex, have immunoregulation action and stimulate the body to generate interferon to improve the body antiviral ability.
After the patients with icteric hepatitis are soaked in raw rhubarb on the basis of comprehensive treatment, the improvement of the symptoms and the recovery of the liver function index of the patients are better than those of a control group, and no obvious side reaction is found in the treatment.
TABLE 1 liver function Change before and after two groups of treatment (x- + -s)
Group n/case
TB/(μmol/L)DB/(μmol/L)ALT/(U/L)ALP/(U/L)GGT/(U/L)
230.5 + -42.2161.7 + -47.0214.8 + -74.6182.2 + -79.3151.0 + -81.4 before treatment for treatment group 31
45.4 +/-25.7 △△ 30.4.4 +/-17.6 △△ 47.8.8 +/-31.3 △ 146.4.4 +/-61.5115.5 +/-60.9 after treatment
Control group 30 before treatment 240.5 + -68.5172.9 + -43.2213.1 + -67.7177.6 + -78.7162.4 + -81.1
82.4 +/-38.547.9 +/-25.461.3 +/-22.6162.3 +/-64.1139.0 +/-86.3 after treatment
The preparation method of the medicine for treating damp-heat jaundice and amenorrhea due to blood stasis provided by the embodiment of the invention is shown in a schematic diagram in fig. 2.
The invention has the effects of purging heat, dredging intestines, cooling blood, detoxifying, removing blood stasis and dysmenorrheal, is used for excess heat constipation, abdominal pain due to stagnation, damp-heat jaundice, blood stasis and amenorrhea and the like, has the main pharmacological actions of being bitter in taste and cold in nature, having the effects of purging, attacking accumulation, clearing heat, detoxifying, activating blood and removing stasis, has wide application in liver disease treatment, and has ① cholagogue action, the rhubarb has the functions of promoting bile secretion, increasing bile excretion, dredging liver capillary bile duct, and having important actions on eliminating liver cell inflammation and promoting liver cell regeneration, ② liver protection action, the rhubarb can obviously reduce ALT activity of liver injury rat serum caused by carbon tetrachloride, reduce liver cell degeneration and necrosis, stimulate large intestine mucosa to reflexively enhance large intestine peristalsis to guide diarrhea, so that pathogens, body toxins and various enterogenic toxic substances and metabolic products remained in the intestines are discharged out of the body, ③ can regulate immunity and antivirus action, the rhubarb can inhibit humoral immunity, enhance cellular immunity, reduce immunoreaction immune response, eliminate immune complexes, has an immunoregulation action, and stimulates the organism to generate interferon to improve the antiviral ability.
The effect of the present invention will be described in detail with reference to specific experiments.
Experiment 1: authentication
(1) The powder was yellowish brown. The cluster crystal diameter of the calcium oxalate is 20-160 mu m. The rimmed hole conduit, the cross-hatched conduit, the threaded conduit and the annular conduit are nonwood. The starch grains are many, the single grains are round or polygonal, the diameter is 3-45 mu m, and the starch grains are in a shape of an umbilical point star; the compound granules consist of 2-8 granules.
(2) Taking 0.5g of the product, adding 20ml of methanol, carrying out ultrasonic treatment for 15 minutes, filtering, evaporating filtrate to dryness, adding 10ml of water into residue, slightly heating to dissolve, adding 5ml of hydrochloric acid, heating and refluxing for 30 minutes, immediately cooling, extracting with diethyl ether for 3 times and shaking for 3 times, 20ml each time, combining ethyl ether solutions, volatilizing at low temperature, and adding 1ml of methanol into residue to dissolve to obtain a sample solution. 0.5g of rhubarb as a reference drug is prepared and then a reference drug solution is prepared by the same method. Testing by thin layer chromatography (appendix VI B of 2010 edition of pharmacopoeia of the people's republic of China), sucking 5 μ l of each of the three solutions, respectively dropping on the same silica gel G thin layer plate with sodium carboxymethylcellulose as binder, developing with petroleum ether (30-60 deg.C) -ethyl formate-formic acid (15:5:1) upper layer solution as developing agent, taking out, air drying, and inspecting under ultraviolet lamp (365 nm).
In the chromatogram of the test solution, five orange yellow fluorescent spots are displayed at the corresponding positions of the chromatogram of the reference medicinal material, and the spots become red after the sample is smoked in ammonia vapor.
Experiment 2: examination of
Meets the regulations of capsules (I L appendix of 2010 edition of pharmacopoeia of the people's republic of China).
Experiment 3: determination of content
Measured according to high performance liquid chromatography (appendix VI D of the 2010 edition of pharmacopoeia of the people's republic of China).
Chromatographic condition and system adaptability test: octadecylsilane chemically bonded silica is used as a filling agent; methanol-0.1% phosphoric acid solution (80: 20) is used as a mobile phase; the detection wavelength was 254 nm. The number of the tower plates is not less than 3000 calculated according to the emodin peak.
Preparing a reference substance solution; accurately weighing emodin reference substance and chrysophanol reference substance, and adding methanol to obtain mixed solution containing emodin 25 μ g and chrysophanol 90 μ g per 1 ml.
Preparing a test solution; precisely weighing about 0.15g of contents under the condition of different filling amounts, placing the contents in a conical flask with a plug, precisely adding 25ml of methanol-hydrochloric acid (12:1) mixed solution, weighing, heating and refluxing for 30 minutes, cooling, weighing again, complementing the weight loss by using the methanol-hydrochloric acid (12:1) mixed solution, shaking up, filtering, and taking the subsequent filtrate to obtain the product.
An assay; precisely sucking 10 μ l of each of the reference solution and the sample solution, injecting into liquid chromatograph, and measuring.
The invention contains emodin (C) in each granule according to dry product15H10O5) And chrysophanol (C)15H10O4) The total amount of (A) should not be less than 4.0 mg.
The dosage of the application provided by the embodiment of the invention is oral administration, 1 granule at a time and 3 times a day; taken after meals; or following the medical advice.
The specification provided by the embodiment of the invention is 0.4 g/grain × 36 grains/bottle.
The embodiment of the invention provides storage: sealing, and standing in a cool and dry place.
The validity period provided by the embodiment of the invention is 2 years.
The capsule provided by the embodiment of the invention has yellow to yellowish brown powder as the content and is bitter in taste.
The specific procedures and parameter settings provided by the embodiment of the invention are described in table 1.
TABLE 1 specific procedures and parameter settings
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (6)
1. The medicine for treating damp-heat jaundice and amenorrhea due to blood stasis is characterized by comprising 450g of rheum officinale.
2. The preparation method of the medicine for treating jaundice due to damp-heat and amenorrhea due to blood stasis as claimed in claim 1, wherein the preparation method of the medicine for treating jaundice due to damp-heat and amenorrhea due to blood stasis comprises the following steps:
the method comprises the following steps: selecting radix et rhizoma Rhei, cleaning, and oven drying to obtain dried radix et rhizoma Rhei;
step two: grinding rhubarb into fine powder, drying in a constant-temperature drying oven in a clean workshop, sieving, and uniformly mixing through a three-dimensional mixer to obtain rhubarb powder 1;
step three: the rhubarb powder 1 is filled into capsules by a full-automatic capsule filling machine to prepare 1000 granules, thus obtaining the medicine for treating damp-heat jaundice and blood stasis amenorrhea.
3. The method for preparing a medicine for treating damp-heat jaundice and blood stasis amenorrhea as claimed in claim 2, wherein the second step is to dry the medicines in a clean workshop and a constant-temperature drying oven for 60 ℃ and 2 hours and pass through a 120-mesh sieve.
4. The method for preparing a medicine for treating jaundice due to damp-heat pathogen and amenorrhea due to blood stasis as claimed in claim 2, wherein the rhubarb powder 1 is filled into capsules by a full-automatic capsule filling machine to prepare 1000 capsules.
5. The method for preparing a medicament for treating jaundice due to damp-heat pathogen and amenorrhea due to blood stasis as claimed in claim 2, wherein each granule of rhubarb powder in the third step is 0.4 g.
6. A capsule prepared from the medicine for treating damp-heat jaundice and amenorrhea due to blood stasis as claimed in claim 1.
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| CN108853189A (en) * | 2018-09-20 | 2018-11-23 | 福建省南平市人民医院（福建省南平市中医院） | A kind of compound gingkgo pulse invigorating capsule and preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108853189A (en) * | 2018-09-20 | 2018-11-23 | 福建省南平市人民医院（福建省南平市中医院） | A kind of compound gingkgo pulse invigorating capsule and preparation method |
Non-Patent Citations (2)
| Title |
|---|
| 国家中医药管理局职业技能鉴定指导中心等编: "《中药固体制剂工》", 30 November 2009 * |
| 谢文英编著: "《名医珍藏百草良方》", 31 May 2014 * |
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