CN111346008A

CN111346008A - Closed transfer dispensing needle and application thereof in dispensing and transferring medicines

Info

Publication number: CN111346008A
Application number: CN202010182895.0A
Authority: CN
Inventors: 陈日志; 谢世庚; 陈伟权; 罗荣琼
Original assignee: Zhanjiang Jianliyuan Medical Supplies Co ltd
Current assignee: Zhanjiang Jianliyuan Medical Supplies Co ltd
Priority date: 2020-03-16
Filing date: 2020-03-16
Publication date: 2020-06-30
Anticipated expiration: 2040-03-16
Also published as: CN111346008B

Abstract

The invention discloses a closed transfer dispensing needle, which comprises a needle seat, a dispensing needle, an air storage device and a sheath. When the medicine dispensing and transferring device is used, the liquid outlet hole and the exhaust hole of the medicine dispensing needle are not nearly contacted with the outside air, the whole sealing of the medicine dispensing and transferring process can be realized to the maximum extent, the medicine is effectively prevented from being leaked and volatilized, and the pressure in the medicine bottle in the medicine dispensing and transferring process is always equal to the outside pressure. The product has simple and compact structure, convenient and safe use and low cost.

Description

Closed transfer dispensing needle and application thereof in dispensing and transferring medicines

Technical Field

The invention belongs to the field of preparation and transfer devices of medicaments, and particularly relates to a closed transfer dispensing needle.

Background

Chemotherapeutic drugs for treating cancer can cause serious harm to healthy people, especially to medical workers who are exposed to the chemotherapeutic drugs for a long time in the process of preparation and transportation. The data published by the american BD company indicate that the hazardous drug exposure in the medical environment is carcinogenic, damages internal organs and organs, DNA damage due to genotoxicity, reproductive problems due to biotoxicity, abortion and teratogenesis. The data show that the cancer incidence of pharmacists and nurses is increased by 3-10 times compared with the general population and the risk of infertility, abortion and the like is increased by 2-5 times due to long-term contact with dangerous drugs.

In this regard, some developed countries have begun to employ isolation systems such as bio-cabinets to prevent or reduce the risk of hazardous drug exposure. However, studies have confirmed that even when these systems are used to formulate and deliver chemotherapeutic agents, large amounts of chemotherapeutic agents are still detected in the ground, gloves, air, and respiratory gases of humans. In recent years, a closed drug preparation and transfer system (CSTD) is developed in the United states, which claims to reduce the pollution of 50-80% of chemotherapeutic drugs, but the CSTD consists of three subsystems, has a very complex structure and a complex use mode, requires replacement of accessories for many times in the use process, causes leakage risks to still exist, has high cost, is difficult for patients to bear, and cannot be popularized and applied in various regions on a large scale.

It is reported that nearly 2.6 billion bottles of chemotherapy drugs are used annually in our country. The chemotherapy medicine can enter human body through skin, digestive tract and respiratory tract. The health of about 1000 million medical workers is affected by long-term exposure in the process of preparation and transportation of chemotherapeutic drugs. Although the hazards of these drugs are known, no practical and generalizable special protective equipment and measures exist in China.

Disclosure of Invention

In view of the deficiencies and needs in the art, it is an object of the present invention to provide a closed transfer dispensing needle. The transfer dispensing needle can realize nearly full sealing of the process of preparing and transferring dangerous medicines, effectively prevents the medicines from leaking and volatilizing, and has the advantages of simple structure, low cost, convenient use and safety.

Specifically, the present invention adopts the following technical solutions.

The utility model provides a dispensing needle is transported to closed, includes needle file, dispensing needle, air reservoir and sheath, its characterized in that:

the dispensing needle is fixedly connected to the needle seat;

the dispensing needle is of a double-layer columnar structure and is provided with an inner column channel and a side ring channel, wherein one channel is used as a transfusion channel and is communicated with the cavity of the needle seat, and the other channel is used as an exhaust channel and is communicated with an air storage device connected to the side surface of the needle seat;

the sheath is sleeved at the front end of the needle seat;

the front end face of the sheath is closed, and a through hole for the dispensing needle to pass through is arranged in the center of the end face; a partition parallel to the front end face is arranged in the sheath close to the front end face, and a through hole for the medicine dispensing needle to pass through is also arranged in the center of the partition;

the space between the front end surface of the sheath and the partition is filled with a closed tube made of elastic material, and the inner diameter of the closed tube is smaller than the outer diameter of the dispensing needle;

a spring is arranged in the sheath, and two ends of the spring are respectively connected with the sheath partition and the front end of the needle seat;

under the non-pressurized state, the spring naturally extends, the sheath shields the dispensing needle inside the sheath, and under the elastic force action of the elastic material, the closed tube tightly wraps the front end part of the dispensing needle and seals the infusion passage port and the exhaust passage port;

under the pressure state, the spring is compressed, and the front end part of the dispensing needle including the infusion channel opening and the exhaust channel opening can penetrate out of the sheath through the through hole in the center of the front end surface of the sheath.

In the closed transfer dispensing needle of the present invention, unless otherwise specified, the front end refers to the end of the dispensing needle at which the needle tip is directed, and the rear end refers to the other end opposite thereto.

In the present invention, the hub is the carrier on which the other components are disposed. The infusion channel of the dispensing needle, the cavity of the needle stand and the injector are communicated by connecting the injector.

In a preferred embodiment, the inner column channel of the dispensing needle is a vent channel, the side ring channel is an infusion channel, and the inner column channel is longer than the side ring channel.

Suitably, the liquid outlet port (i.e., the liquid feeding passage port) of the liquid feeding passage is provided on the side of the front end of the side ring passage, and the gas discharge port (i.e., the gas discharge passage port) of the gas discharge passage is provided on the side of the front end of the inner column passage. The provision of the access port on the side helps to achieve a wrap-around seal of the closure tube within the sheath against the dispensing needle access port in the ready-to-use state (i.e. non-operative state) to ensure that medicament does not leak out to the atmosphere through the access port. If the passage opening is provided at the front needle tip of the dispensing needle, there is a risk that the closed tube cannot sufficiently wrap the sealed passage opening.

The liquid outlet hole is arranged at the rear end of the exhaust hole, and the purpose is to fit the operation habit of medical personnel in the process of preparing the medicament. When the medical staff operates, the medicament bottle filled with the liquid medicament is usually inverted, the needle point of the dispensing needle is upwards inserted into the medicament bottle, and the liquid outlet hole is positioned below the dispensing needle, so that the liquid medicament is favorably and fully sucked. If the liquid outlet hole is arranged too far forward, the liquid medicine at the bottle mouth can not be smoothly sucked, so that the medicine is wasted or the operation risk is promoted due to secondary operation.

As a preferred embodiment, one side of the needle seat is provided with a transom communicated with the exhaust channel, a water-blocking film is arranged in the transom, and the air storage device is arranged on the transom. The purpose of the water-blocking film is to make the channel only pass gas but not liquid.

The closed type transferring and dispensing needle is provided with the air storage device, so that the air pressure in the medicine bottle is always kept consistent with the outside in the medicine preparing and transferring processes, and the problem that the medicine liquid is difficult to absorb due to negative pressure in the bottle when the medicine liquid is absorbed or the medicine liquid and/or medicine gas are sprayed out of a needle hole of the bottle mouth when the needle is pulled out due to high pressure in the bottle when the medicine is injected is avoided. In a preferred embodiment, the air storage device comprises an air chamber and an air bag positioned in the air chamber, the air bag is communicated with the transom, the air chamber is fixedly arranged outside the transom, and the air chamber is provided with at least one vent hole communicated with the atmosphere so as to ensure that the pressure inside the air bag is equal to the external environment. When the air bag is used, the air bag can be communicated with the inside of the medicament bottle through the exhaust channel, and the medicament bottle can be ensured to constantly keep equal internal and external pressure in the liquid injection or liquid absorption process through self deformation.

As one of the core components of the closed transfer dispensing needle, a sheath is sleeved at the front end of a needle seat. The length of the sheath can be flexibly set according to the length of the dispensing needle; the radial dimension of the jacket may be uniform or different in the axial direction, and illustratively, the radial dimension of the front end of the jacket may be less than, equal to, or greater than the dimension of the rear end, bounded by the partition surface.

In order to ensure that the sheath can smoothly stretch and move on the needle seat along the axial direction, the sleeving connection part of the sheath and the needle seat is not sealed. Therefore, in order to prevent the needle body of the dispensing needle from being polluted by the outside in the process of medicament preparation and transportation, a folding tube is preferably sleeved outside the needle body between the sheath partition and the front end of the needle base. The dispensing needle passes through the folding tube, and the folding tube can be folded and compressed and restored along with the movement of the sheath. More preferably, the folded tube is disposed against the needle body.

As a preferred embodiment, the spring is arranged in a mode of being coaxial with the dispensing needle, and two ends of the spring are fixedly connected with the sheath partition and the front end of the needle seat respectively. When a folded tube is provided, it is preferably provided between the needle body and the spring.

The closed pipe and the folding pipe are both made of elastic materials, preferably any one of rubber, silica gel and synthetic rubber. Suitable elastic materials should meet the relevant standards for medical materials, as will be readily known and established by those skilled in the art.

The closed transfer dispensing needle of the present invention can be adapted to most existing syringes. With a full understanding of the above-described configuration of the closed transfer dispensing needle of the present invention, it will be readily apparent to those skilled in the art how to use it for drug formulation and transfer.

Generally, after being fixedly connected with the syringe, the using process can comprise the following steps:

1) aligning and attaching the front end face of the sheath with the bottle mouth of the medicament bottle A, and extruding along the axial direction of the dispensing needle to enable the front end part of the dispensing needle to penetrate through the sheath and penetrate into the medicament bottle A;

2) pulling the piston of the injector to suck the liquid medicine; in the link, as the liquid medicine is sucked, the air pressure in the medicine bottle A is reduced, and part of air in the air bag enters the medicine bottle A through the exhaust passage, so that the inside and the outside of the medicine bottle A are in equal pressure;

3) after the liquid medicine is sucked, gradually removing the axial pressure applied to the sheath, simultaneously slowly pulling out the dispensing needle until the spring is reset, tightly wrapping the front end part of the dispensing needle by the sealing tube, and sealing the liquid outlet hole and the exhaust hole;

4) similar to the step 1), aligning and attaching the front end face of the sheath with the bottle mouth of the medicament bottle B, and extruding along the axial direction of the dispensing needle to enable the front end part of the dispensing needle to penetrate out of the sheath and penetrate into the medicament bottle B;

5) pushing the piston of the injector to inject the liquid medicine into the medicine bottle B; in the link, along with the injection of the liquid medicine, the air pressure in the medicine bottle B is increased, and part of the air is discharged into the air bag through the exhaust passage, so that the inside and the outside of the medicine bottle B are in equal pressure;

6) after the liquid medicine is injected, the axial pressure applied to the sheath is gradually removed, the dispensing needle is slowly pulled out at the same time until the spring is reset, the front end part of the dispensing needle is tightly wrapped by the sealing tube again, and the liquid outlet hole and the exhaust hole are sealed inside.

By the method, the purposes of preparing mixed medicaments, transferring prepared liquid medicaments into infusion bottles or indwelling needles and the like can be achieved.

Compared with the prior art, the invention has the following beneficial effects:

(1) by using the closed transfer dispensing needle, the liquid outlet hole and the exhaust hole of the dispensing needle are nearly not contacted with the outside air, so that the full sealing of the process of dispensing and transferring the medicine can be realized to the maximum extent, and the medicine is effectively prevented from leaking and volatilizing;

(2) in the process of dispensing and transferring, the pressure in the medicament bottle is constantly equal to the external pressure, so that the difficulty in sucking the liquid medicament is avoided, or the liquid medicament is sprayed or gas is discharged from a bottle mouth pinhole due to overhigh pressure in the bottle at the moment of pulling the needle;

(3) the product has simple and compact structure, convenient and safe use and low cost.

Drawings

FIG. 1 is a schematic view of the construction of a closed transfer dispensing needle of the present invention;

FIG. 2 is a schematic view of the front end of the dispensing needle;

FIG. 3 is a schematic view of the closed transfer dispensing needle of the present invention in the state of being connected to a syringe;

FIG. 4 is a representative pictorial view of a closed transfer dispensing needle of the present invention in the connected syringe state;

fig. 5 is a diagram showing a test result in the embodiment using the three-way uv analyzer.

Detailed Description

The present invention will be described in further detail with reference to the following examples and drawings, but the present invention should not be construed as being limited to the scope of the present invention.

Examples

Fig. 1 is a schematic view of the structure of a closed transfer dispensing needle of the present invention. As shown in the figure, the closed transfer dispensing needle comprises a dispensing needle 2, a needle base 3, a sheath 4, and a gas reservoir 5.

Wherein, the dispensing needle 2 is fixedly connected on the needle stand 3.

The dispensing needle 2 is a double-layer columnar structure having an inner column channel and a side ring channel, and the inner column channel is slightly longer than the side ring channel (as shown in fig. 2). Wherein, the side ring channel is a transfusion channel 21 which is communicated with the cavity of the needle seat 3, and the inner column channel is an exhaust channel 22. The liquid outlet hole 211 of the liquid feeding channel 21 is positioned at the front end side of the side ring channel, and the exhaust hole 221 of the exhaust channel 22 is positioned at the front end side of the inner column channel.

One side of the needle seat 3 is provided with a transom 31 communicated with the exhaust passage 22, and a water-blocking film 32 is arranged in the transom 31.

The air reservoir 5 includes an air chamber 51 and an air bag 52 located in the air chamber 51, and the air chamber 51 is provided with a vent 511 communicating with the atmosphere. The airbag 52 communicates with the louver 31, and the air cell 51 is fixedly attached to the outside of the louver 31. In the standby state, a certain amount of air is stored in the air bag 52.

The sheath 4 is sleeved at the front end of the needle base 3.

The front end face of the sheath 4 is closed and a through hole 42 for the dispensing needle 2 to pass through is arranged at the center of the end face. A partition parallel to the front end face is arranged in the sheath 4 close to the front end face, and a through hole for the dispensing needle 2 to pass through is also arranged in the center of the partition.

The space between the front end surface of the sheath 4 and the partition is filled with a closed tube 6 made of medical elastic rubber, and the inner diameter of the closed tube 6 is smaller than the outer diameter of the dispensing needle 2.

A spring 41 is arranged between the partition of the sheath 4 and the front end of the needle seat in a manner of being coaxial with the dispensing needle 2, and two ends of the spring 41 are respectively fixedly connected with the partition of the sheath and the front end of the needle seat. And between the spring 41 and the needle body, a folding tube 61 which can be folded, compressed and restored along with the movement of the sheath 4 is arranged closely to the needle body, and the folding tube 61 is also made of medical elastic rubber.

Fig. 1 shows a closed transfer dispensing needle of the present invention in a ready-to-use state. At this point, the sheath 4 is in an uncompressed state, the spring 41 naturally expands, and the sheath 4 shields the dispensing needle 2. Under the elastic force of the elastic rubber, the front end part of the dispensing needle 2 is tightly wrapped by the sealing tube 6, and the liquid outlet hole 211 and the exhaust hole 221 are sealed inside.

The closed transfer dispensing needle of the present invention can be adapted to most existing syringes. Fig. 3 is a schematic view of the closed transfer dispensing needle of the present invention in a state where it is connected to a syringe. By connecting the needle holder 3 with the syringe 1, the infusion channel 21 of the dispensing needle 2, the cavity of the needle holder 3 and the syringe 1 are put into communication.

When the closed transfer dispensing needle is used for medicament preparation and transfer, the liquid outlet hole 211 and the exhaust hole 221 of the dispensing needle 2 are nearly not contacted with the outside air, so that leakage and volatilization of liquid medicament and gas can be effectively prevented. And the pressure in the medicine bottle is constantly equal to the pressure outside, so that liquid medicine or exhaust gas cannot be sprayed out of a bottle mouth pinhole due to overhigh internal pressure at the moment of needle pulling.

Application examples

The performance advantages of the closed transfer dispensing needle of the present invention over the prior art have been described in detail above. In order to further verify the technical effect, application experiments are carried out by using actual products.

1. Site of experiment

Product research and development laboratory of Zhanjiang Jianliyuan medical supplies GmbH.

2. Test object

As the experimental sample, a syringe equipped with the closed transfer dispensing needle of the present invention as shown in FIG. 4 was used, and the syringe size was 20 mL. In the figure, fig. 4a is a sample object diagram in a standby state, and fig. 4b is a sample object diagram with a part of the components detached (to show the internal structure more clearly).

A conventional dispensing needle (i.e., a conventional syringe, gauge: 20mL) commonly used in the art was used as a comparative sample.

3. Experimental methods

3.1 use of the test samples

1) 20mL of a 10g/L aqueous solution of fluorescein sodium was added to a vial (specification: 40mL), sealing by an aluminum cap chlorinated butyl rubber plug, and marking as a penicillin bottle A; filling 10mL of purified water into another penicillin bottle (specification: 40mL), sealing with an aluminum cap chlorinated butyl rubber plug, and marking as a penicillin bottle B; and (5) standby.

2) Aligning and attaching the front end face of a sheath of the closed transfer dispensing needle with the bottle mouth of the penicillin bottle A, wrapping the attaching part with qualitative filter paper, and then extruding along the axial direction of the dispensing needle to enable the front end part of the dispensing needle to penetrate out of the sheath and penetrate into the penicillin bottle; the plunger of the syringe is then pulled and 10mL of the sodium fluorescein solution is aspirated.

3) After the sucking is finished, gradually removing the axial pressure, simultaneously slowly pulling out the dispensing needle until the spring is reset, tightly wrapping the front end part of the dispensing needle by the sealing tube again, and sealing the liquid outlet hole and the exhaust hole; and then, finishing the attaching state of the closed transfer dispensing needle and the penicillin bottle mouth, and taking down the qualitative filter paper.

4) Aligning and attaching the front end face of the sheath of the experimental sample filled with the fluorescein sodium solution with the bottle opening of the penicillin bottle B, wrapping the attaching part with the qualitative filter paper taken out in the step 3), and then extruding along the axial direction of the dispensing needle to enable the front end part of the dispensing needle to penetrate out of the sheath and penetrate into the penicillin bottle; then the piston of the syringe is pushed to inject the sodium fluorescein solution into the penicillin bottle B.

5) After the injection is finished, gradually removing the axial pressure, simultaneously slowly pulling out the dispensing needle until the spring is reset, tightly wrapping the front end part of the dispensing needle by the sealing tube, and sealing the liquid outlet hole and the exhaust hole; and then, finishing the attaching state of the closed transfer dispensing needle and the penicillin bottle mouth, and taking down the qualitative filter paper.

6) A three-way ultraviolet analyzer (model: ZF-1) the removed qualitative filter paper was examined. The specific method comprises the following steps: and (3) placing the qualitative filter paper taken down in the step 5) on an operation table of a three-purpose ultraviolet analyzer, starting the device to enable ultraviolet light to irradiate the qualitative filter paper, and observing whether fluorescent spots appear on the qualitative filter paper.

3.2 use of comparative sample

1) Referring to step 1) in 3.1, preparing a penicillin bottle A and a penicillin bottle B for later use.

2) Aligning the needle point of an injection needle of a common injector (namely a common dispensing needle) to the bottle opening of the penicillin bottle A, wrapping the bottle opening of the penicillin bottle and the injection needle of the common injector by qualitative filter paper, and then extruding along the axial direction of the injector to ensure that the injection needle penetrates into the penicillin bottle; the plunger of the syringe is then pulled and 10mL of the sodium fluorescein solution is aspirated.

3) After the aspiration, the needle was slowly withdrawn and the qualitative filter paper was removed.

4) Aligning the needle point of the injection needle of the common injector filled with the sodium fluorescein solution to the bottle opening of the penicillin bottle B, wrapping the bottle opening of the penicillin bottle and the injection needle of the common injector by using the qualitative filter paper taken out in the step 3), and then extruding along the axial direction of the injector to ensure that the injection needle penetrates into the penicillin bottle; then the piston of the syringe is pushed to inject the sodium fluorescein solution into the penicillin bottle B.

5) After the injection was completed, the injection needle was slowly withdrawn, and the qualitative filter paper was removed.

6) See step 6) in fig. 3.1), the removed qualitative filter paper is tested.

4. Results of the experiment

The results of the measurement using the three-way ultraviolet analyzer are shown in fig. 5. Wherein fig. 5a shows the result of the test using the syringe equipped with the closed transfer dispensing needle of the present invention, and fig. 5b shows the result of the test using the conventional dispensing needle. It can be seen that:

(1) by using the closed transfer dispensing needle, no fluorescent spot appears on the finally obtained qualitative filter paper, and the bottle mouth of the penicillin bottle B is very clean, which indicates that no solution leaks in the using process;

(2) by using a common dispensing needle, yellow-green fluorescent spots with obvious and large range appear on the finally obtained qualitative filter paper, and the bottle mouth of the penicillin bottle B also has obvious fluorescence at the periphery of the needle hole, which indicates that a larger solution leakage problem exists in the using process. The leakage is mainly caused by the fact that the pressure in the bottle is too high when the needle is withdrawn, and solution is sprayed and gas is discharged from a needle hole of the bottle mouth.

The figures also show the condition of the used experimental sample and the comparative sample on the three-way ultraviolet analyzer. In the experimental sample, the appearance of the sample, particularly the front end of the closed transfer dispensing needle, did not show any fluorescence except a small amount of permeation fluorescence caused by the solution adhering and remaining inside the sample. When the closed type transfer dispensing needle is used, the liquid outlet hole and the exhaust hole of the dispensing needle are nearly not contacted with the outside air, the preparation and transfer processes are totally closed, and the leakage and volatilization of the solution are effectively prevented. When a common dispensing needle is seen, the needle tip of the injection needle is exposed, obvious yellow-green fluorescence is displayed, liquid medicine is easy to leak and volatilize from the needle tip, and hidden danger of accidental injury of personnel exists.

In addition, the experimental sample and the general dispensing needle also show differences in handling. When the injector provided with the closed transfer dispensing needle is used, the injection and the suction of the solution are very smooth due to the fact that the inner and outer equal pressure of the penicillin bottle can be ensured; when a common dispensing needle is used for sucking and injecting the solution, the force is gradually increased to overcome the internal and external pressure difference of the penicillin bottle, and the operation difficulty is obviously improved.

The foregoing description is only exemplary of the invention. From the above, those skilled in the art can make various changes and modifications without departing from the technical idea of the present invention. The protection scope of the present invention is not limited to the above-mentioned embodiments, but is subject to the scope defined by the claims.

Claims

1. The utility model provides a dispensing needle is transported to closed, includes needle file, dispensing needle, air reservoir and sheath, its characterized in that:

the dispensing needle is fixedly connected to the needle seat;

the sheath is sleeved at the front end of the needle seat;

2. The closed transfer dispensing needle of claim 1, wherein: the inner column channel of the dispensing needle is an exhaust channel, the side ring channel is an infusion channel, and the inner column channel is longer than the side ring channel.

3. The closed transfer dispensing needle of claim 2, wherein: the liquid outlet hole of the transfusion channel is arranged at the front end side part of the side ring channel, and the exhaust hole of the exhaust channel is arranged at the front end side part of the inner column channel.

4. The closed transfer dispensing needle of claim 1, wherein: one side of the needle seat is provided with a transom communicated with the exhaust passage, a water-blocking film is arranged in the transom, and the air storage device is arranged on the transom.

5. The closed transfer dispensing needle of claim 4, wherein: the air storage device comprises an air chamber and an air bag positioned in the air chamber, the air bag is communicated with the transom, the air chamber is fixedly arranged on the outer side of the transom, and at least one vent hole communicated with the atmosphere is formed in the air chamber.

6. The closed transfer dispensing needle of claim 1, wherein: the radial size of the front end of the sheath is smaller than, equal to or larger than the size of the rear end by taking the partition surface as a boundary.

7. The closed transfer dispensing needle of claim 1, wherein: a folding tube is sleeved outside the needle body between the sheath partition and the front end of the needle base; preferably, the folded tube is disposed against the needle body.

8. The closed transfer dispensing needle of claim 1, wherein: the spring is arranged in a mode of being coaxial with the dispensing needle, and two ends of the spring are respectively fixedly connected with the sheath partition and the front end of the needle seat.

9. The closed transfer dispensing needle of claim 8, wherein: a folding tube is arranged between the needle body and the spring; preferably, the folded tube is disposed against the needle body.

10. A closed transfer dispensing needle according to any one of claims 1 to 9, wherein: the closed tube and the folding tube are both made of elastic materials, preferably any one of rubber, silica gel and synthetic rubber.

11. Use of the closed transfer dispensing needle of any one of claims 1 to 10 for dispensing and transferring a medicament, comprising the steps of:

2) pulling the piston of the injector to suck the liquid medicine;

4) aligning and attaching the front end face of the sheath with the bottle mouth of the medicament bottle B, and extruding along the axial direction of the dispensing needle to enable the front end part of the dispensing needle to penetrate through the sheath and penetrate into the medicament bottle B;

5) pushing the piston of the injector to inject the liquid medicine into the medicine bottle B;