CN111328733B

CN111328733B - Running equipment for white mice

Info

Publication number: CN111328733B
Application number: CN202010178356.XA
Authority: CN
Inventors: 黄慧雅; 孙佳; 黄晓忠; 牛超; 叶炜剑; 林孝坤
Original assignee: First Affiliated Hospital of Wenzhou Medical University
Current assignee: First Affiliated Hospital of Wenzhou Medical University
Priority date: 2020-03-13
Filing date: 2020-03-13
Publication date: 2021-08-31
Anticipated expiration: 2040-03-13
Also published as: CN111328733A

Abstract

The invention discloses a running device for mice, which adopts the technical scheme that the running device comprises: a plurality of guide rails and rotating cages, wherein the two ends of the guide rails in the length direction are respectively provided with a connecting piece, the guide rails comprise straight rails in a linear shape and arc rails in an arc shape, and assemble into the runway of return circuit formula through a plurality of straight rails and a plurality of arc rails through the connecting piece, the rotating cage is including being used for holding cage and butt edge, the butt edge is provided with two and all is the setting of loop configuration, be provided with the guide way on the guide rail, the guide way extends the setting along guide rail length direction, rotating cage and guide rail all have electrically conductive material to make, a guide rail is connected with discharge apparatus, running equipment is still including analog device, analog device is including the simulation shell, and set up the simulator in the simulation shell, the simulation shell corresponds a guide rail position department and has seted up the shell opening, analog device is still including the shutoff shell, this equipment can be convenient, effectual control mice runs under appointed environment.

Description

Running equipment for white mice

Technical Field

The invention relates to experimental equipment, in particular to running equipment for a white mouse.

Background

The white mouse is widely used for experiments and tests on safety, toxicity, efficacy and the like of food, cosmetics, medicines, biological products, industrial products, medicine, life science and the like; the performance of mice as experimental subjects came from: 1. the gene sequence of mice is almost that of humans; 2. sufficient in quantity (strong in reproductive capacity).

Running is one of important ways for researching the life science of the mice, the existing way is to enable the mice to enter a running wheel to run autonomously, the surrounding environment does not change in the running process (like running in situ), data shows that individuals cultured in rich environments have better learning and memory capabilities than individuals cultured in monotonous environments, and the rich running environments and the monotonous running environments have different influences on the cultivation and life science of the mice, so that equipment for conveniently and effectively controlling the mice to run in the specified environment (rich environment) is needed.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide a running device for a white mouse, which can conveniently and effectively control the white mouse to run under a specified environment.

In order to achieve the purpose, the invention provides the following technical scheme: a white mouse running device, comprising: the rotary cage moving along the length direction of the guide rails, two ends of each guide rail in the length direction are provided with connecting pieces connected with the other guide rail, each guide rail comprises a straight rail in a linear shape and an arc rail in an arc shape, and a loop type runway is assembled by the connecting pieces through the straight rails and the arc rails;

the rotating cage comprises a containing cage which is used for containing the mice and is arranged in a hollow columnar structure and abutting edges which are arranged on the outer side wall of the containing cage and abut against the guide rail, two abutting edges are arranged and are both arranged in an annular structure, the guide rail is provided with a guide groove which is used for embedding the abutting edges and has a guiding function, the guide groove extends along the length direction of the guide rail, and the abutting edges can move along the direction of the guide groove when the mice run in the containing cage;

the rotating cage and the guide rail are both made of conductive materials, and one guide rail is connected with a discharging device for stimulating the white mouse;

the running equipment further comprises simulation equipment, the simulation equipment comprises a simulation shell used for covering the runway and the rotating cage and a simulator arranged in the simulation shell and used for simulating a light source, temperature, humidity and wind power, a shell opening used for placing the rotating cage on the guide rail is formed in the position, corresponding to the guide rail, of the simulation shell, and the simulation equipment further comprises a plugging shell used for plugging the shell opening.

The invention is further configured to: the simulation shell comprises a straight shell used for covering the straight rail and an arc shell used for covering the arc rail, and the straight shell and the arc shell respectively surround a cavity for the rotation cage to move with the straight rail and the arc rail.

The invention is further configured to: the cross section of the simulation shell is of an arch structure and can cover each section of guide rail respectively, and the simulation shell extends along the direction of the runway.

The invention is further configured to: the runway, the simulation equipment and the rotating cage are respectively provided with two groups, the two runways are arranged in an inner-outer ring structure, a shared track is arranged on the two runways, the shared track comprises a main track, two branch tracks are respectively arranged at two ends of the main track and are communicated with the rest parts of the two runways through the branch tracks, guide grooves which can be respectively communicated with the two branch tracks are arranged on the main track, and direction changing devices for changing the moving direction of the rotating cage are respectively arranged on upper forks and lower forks of the shared track;

the turning device is including the diversion piece that plays the guide effect to the cage and drive diversion piece pivoted deviator, one side of diversion piece towards the guide rail is provided with a fixed column and a removal post, be provided with the fixed orifices that supplies the fixed column to pass on the guide rail to and supply to remove the gliding removal spout of post, it is the arc structure setting and extends the setting along the width direction of guide rail to remove the spout, the fixed orifices is located main track one side, it is located branch track one side to remove the spout, the deviator is including the movable plate of being connected with the removal post and the driver part that the drive movable plate removed, one side of guide rail is provided with the passageway that supplies the movable plate to pass and remove the column connection.

The invention is further configured to: the position of the housing opening is located at the position of the main rail.

The invention is further configured to: and a tachometer for recording the rotating speed of the rotating cage is arranged at the center of the abutting edge of the outer side wall.

The invention is further configured to: the rotating cage is made of an aluminum alloy material, and the guide rail is made of an iron material.

The invention is further configured to: the simulated housing is made of one-way glass with the interior visible only from the outside.

The invention is further configured to: the butt edges are respectively arranged at two ends of the accommodating cage.

In conclusion, the invention has the following beneficial effects: can place a plurality of guide rails in the experiment place, assemble into return circuit formula runway, make things convenient for mice and rotating cage circulated running, through the design of the certain degree of depth of guide way, when the butt is along being located the guide way, the both sides on butt edge can touch with the both sides of guide way mutually to the stability of reinforcing rotating cage makes mice can not appear the phenomenon that the derail, emptys at the running in-process. The environment near the runway is simulated through the simulation equipment, so that the ideal environment requirement of an experimenter is met, the comparison with a white mouse running in a fixed rotating cage can be realized, the data difference between outdoor running and indoor running is explored through the comparison of long-time and big data, and whether different influences are caused to people is also explored.

Drawings

FIG. 1 is a schematic perspective view of the assembled runway and simulation equipment;

FIG. 2 is a schematic perspective view of a straight rail;

FIG. 3 is a schematic diagram of the structure of the common track before changing direction;

FIG. 4 is a schematic diagram of the common rail shown in a backward configuration;

FIG. 5 is an exploded view of the common track and direction changing block;

fig. 6 is a schematic perspective view of the rotary cage.

Reference numerals: 1. a guide rail; 11. a runway; 12. a guide groove; 13. inserting a block; 14. a jack; 15. a fixing hole; 16. a moving chute; 18. a discharge device; 2. rotating the cage; 21. an abutting edge; 22. an accommodating cage; 23. a speed recorder; 3. simulating equipment; 31. simulating a housing; 311. a straight shell; 312. an arc shell; 32. a housing opening; 33. plugging the shell; 4. a common track; 41. a main track; 42. dividing tracks; 5. a direction changing device; 51. a turning block; 511. fixing a column; 512. moving the column; 52. a direction changer; 521. moving the plate; 522. a drive member.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings and examples. In which like parts are designated by like reference numerals. It should be noted that the terms "front," "back," "left," "right," "upper" and "lower" used in the following description refer to directions in the drawings, and the terms "bottom" and "top," "inner" and "outer" refer to directions toward and away from, respectively, the geometric center of a particular component.

Referring to fig. 1 to 6, in order to achieve the above object, the present invention provides the following technical solutions: a white mouse running device, comprising: the rotary cage comprises a plurality of guide rails 1 and a rotary cage 2 moving along the length direction of the guide rails 1, wherein two ends of each guide rail 1 in the length direction are respectively provided with a connecting piece connected with the other guide rail 1, each guide rail 1 comprises a straight rail in a linear shape and an arc rail in an arc shape, and a loop type runway 11 is assembled by the straight rails and the arc rails through the connecting pieces; the runway 11 of different footpath length is assembled into through the straight rail of different numbers and different arc length type arc rails to be applicable to the different experimental requirement of experimenter, experimental study can receive the restriction in the aspect of the multiple reality of topography, place, fund occasionally, and this design has fine adaptability. The loop type track 11 can enable the mice to run circularly like an playground, the connecting piece can be in a mode of the insertion block 13 and the insertion hole 14, a layer of guarantee is provided for the guide rail 1 to be attached to the guide rail 1 through the insertion block 13 and the insertion hole 14, and the phenomenon that the two guide rails 1 are separated due to shaking is avoided in the running process of the mice.

This rotating cage 2 is unanimous with fixed rotating cage 2 among the prior art on the whole, serves to be provided with and places the opening in holding cage 22 with the mice to and the door with the opening shutoff, and the both ends of rotating cage 2 all are network structure: 1. the weight of the rotating cage 2 can be reduced, and materials are saved; 2. the air permeable rotary cage provides a smooth environment for the mice in the rotary cage 2 and has an air permeable function;

the rotating cage 2 comprises an accommodating cage 22 which is used for accommodating a mouse and is arranged in a hollow columnar structure and an abutting edge 21 which is arranged on the outer side wall of the accommodating cage 22 and abutted to the guide rail 1, wherein the abutting edge 21 is provided with two parts which are annular, the guide rail 1 is provided with a guide groove 12 which is used for embedding the abutting edge 21 and has a guiding function, the guide groove 12 extends along the length direction of the guide rail 1, and the abutting edge 21 can move along the direction of the guide groove 12 when the mouse runs in the accommodating cage 22; the length of the diameter of the abutting edge 21 is larger than that of the accommodating cage 22, and the accommodating cage 22 is not abutted to the guide rail 1 when the abutting edge 21 is abutted to the guide rail 1, so that the contact area is reduced, and the running of a white mouse is facilitated; secondly be provided with two guide way 12 on the guide rail 1, correspond each butt respectively along 21 to through the design of the certain degree of depth of guide way 12, when the butt is located guide way 12 along 21, the butt can touch with the both sides of guide way 12 along 21 both sides, thereby reinforcing rotating cage 2's stability, make the mouse can not appear the phenomenon that the derail, emptys at the running in-process.

The running of the mice can be carried out in a dynamic environment by matching the runway 11 with the rotating cage 2, so that the mice are compared with the suspended fixed cage in the air in a difference mode, and the experimental purpose is achieved.

The rotating cage 2 and the guide rail 1 are both made of conductive materials, and one guide rail 1 is connected with a discharging device 18 for stimulating a white mouse; considering that the white mouse is placed in the rotating cage 2 for the first time and does not necessarily run voluntarily, in order to cultivate the voluntary and habit of the white mouse, the white mouse runs by current stimulation when the white mouse does not run, and the running habit is cultivated over time. The discharge device 18 is connected to the guide rail 1 by a wire.

The running device further comprises a simulation device 3, the simulation device 3 comprises a simulation shell 31 used for covering the runway 11 and the rotating cage 2 and a simulator arranged in the simulation shell 31 and used for simulating light source, temperature, humidity and wind power, a shell opening 32 used for placing the rotating cage 2 on the guide rail 1 is formed in the position, corresponding to the guide rail 1, of the simulation shell 31, and the simulation device 3 further comprises a blocking shell 33 used for blocking the shell opening 32. An experimenter puts the abutting edge 21 of the rotating cage 2 into the guide groove 12 of the guide rail 1 through the shell opening 32, and then uses the blocking shell 33 to block the shell opening 32, so that the influence of the environment outside the simulated shell 31 on the simulated environment in the simulated shell 31 is avoided; the design of the simulation device 3 can simulate running environment, such as morning running and night running, and according to data calculation of the morning running mouse and the night running mouse, whether the morning running and the night running bring difference promotion to human beings, and what difference promotion the morning running and the night running specifically bring. And simulating the illuminance and humidity in different seasons, and deducing the influence on human according to the influence of outdoor running on the mice in different seasons.

The simulation shell 31 comprises a straight shell 311 for covering the straight rail and an arc shell 312 for covering the arc rail, wherein the straight shell 311 and the arc shell 312 respectively surround a cavity for the rotation cage to move with the straight rail and the arc rail. This design of simulation shell 31 structure establishes the tunnel shape with the space of running to reduce the required space of simulation environment, for surrounding whole runway 11 (contain the guide rail 1 outer part) and go on, the simulation of minizone is more accurate, but also can the energy saving, for experiment reduction experiment cost.

The runways 11, the simulation equipment 3 and the rotating cage 2 are provided with two groups, the two runways 11 are arranged in an inner and outer ring structure, one of the two runways 11 is larger, the other one of the two runways 11 is smaller, the larger runway 11 comprises the smaller runway 11, the two runways 11 are provided with a shared track 4, the shared track 4 comprises a main track 41, two branch tracks 42 are respectively arranged at two ends of the main track 41 and are communicated with the rest parts of the two runways 11 through the branch tracks 42, guide grooves 12 which can respectively lead to the two branch tracks 42 are arranged on the main track 41, the shared part of the shared track 4 is in a linear type, two arc-shaped guide rails 1 are connected from the inner sides of the linear type guide rails 1, thereby forming the shared track 4, the main track 41 is provided with not only the guide grooves 12 which are originally communicated with the linear type branch tracks 42, but also provided with the guide grooves 12 which can be bent to move towards the arc-shaped guide rails 1, the upper fork and the lower fork of the common track 4 are both provided with a direction changing device 5 for changing the movement direction of the rotating cage 2;

the direction changing device 5 comprises a direction changing block 51 for guiding the rotating cage 2 and a direction changing device 52 for driving the direction changing block 51 to rotate, wherein one side of the direction changing block 51, which faces the arc-shaped guide rail 1, is arc-shaped, so that the direction changing block 51 and a guide groove 12 formed by the side wall of the guide rail 1 after rotating have a certain radian, and the rotating cage 2 is better guided to move; one side of the direction changing block 51, which faces the guide rail 1, is provided with a fixed column 511 and a moving column 512, the guide rail 1 is provided with a fixed hole 15 through which the fixed column 511 passes and a moving chute 16 through which the moving column 512 slides, the moving chute 16 is arranged in an arc structure and extends along the width direction of the guide rail 1, the fixed hole 15 is located on one side of the main rail 41, the moving chute 16 is located on one side of the sub-rail 42, the direction changer 52 comprises a moving plate 521 connected with the moving column 512 and a driving part 522 for driving the moving plate 521 to move, and one side of the guide rail 1 is provided with a channel through which the moving plate 521 passes and is connected with the moving column 512. First, the driving member 522 may be a driving motor or a driving cylinder, and the driving member 522 can drive the moving column 512 to two state positions: 1. the turning block 51 blocks the guide groove 12 on the right side of the linear guide rail 1, and the rotating cage 2 moves to move towards the direction of the arc-shaped guide rail 1 along with the existing guide groove 12 and the turning block 51; 2. the turning block 51 blocks the guide groove 12 on the left side of the arc-shaped guide rail 1, and at the moment, the rotating cage 2 moves back and forth along with the existing guide groove 12 and the turning block 51 to move towards the linear guide rail 1. Thereby having the functions of guiding and changing the direction of the rotating cage 2. The design of the fixing column 511 can ensure that one end of the direction changing block 51 is fixed and cannot move, and the guiding function is achieved.

The design of the coincidence type runway 11 can establish a changeable and abundant environment for the mice, so as to demonstrate whether the influence of the changeable and abundant environment on the mice is different relative to a single environment or not, and the specific difference can be fed back through what value.

The position of the housing opening 32 is at the position of the main rail 41. The rotating cage 2 is placed on the main track 41, the required runway 11 can be directly selected to start through the direction changing device 5, if the shell opening 32 on the overlapped area needs to firstly perform the motion of the simulated environment of the runway 11, or two shell openings 32 are arranged, so that the design is complex, the operation is inconvenient, and the convenience is far less than that of arranging the shell opening 32 on the main track 41.

A tachometer 23 for recording the rotation speed of the rotating cage 2 is arranged at the center of the outer side wall of the abutting edge 21. The tachograph 23 reflects the running speed of the white mouse through the rotating speed of the rotating cage 2, so that more complete data are provided for experimental data.

The rotating cage 2 is made of aluminum alloy materials, and the guide rail 1 is made of iron materials. Aluminum alloys have low density and good electrical conductivity: 1. the discharge device 18 is convenient to conduct electricity; 2. the weight is lighter, and the rotation cage 2 is driven to rotate when the white mouse runs conveniently, and the iron material has good conductivity, high strength and high density.

The dummy housing 31 is made of a one-way glass whose inside can be seen only from the outside. Make things convenient for the audio-visual mouse state of observing in the simulation shell 31 of outside laboratory glassware under the prerequisite of guaranteeing that external light can not cause the interference to the simulation environment in the simulation shell 31, for set up the camera in simulation shell 31, it is more directly perceived clear, do not have the blind angle.

The abutment rims 21 are provided at both ends of the accommodating cage 22, respectively. The condition about the mice can appear removing when the mice runs in holding the cage 22 to cause the focus of rotating cage 2 to appear changing, the phenomenon that rotating cage 2 emptys appears easily, the butt sets up respectively in the structural design who holds the both ends of cage 22 along 21 and can keep rotating cage 2's stability, avoids appearing the phenomenon of empting.

The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above-mentioned embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention. It should be noted that modifications and embellishments within the scope of the invention may occur to those skilled in the art without departing from the principle of the invention, and are considered to be within the scope of the invention.

Claims

1. A running device for mice is characterized by comprising: the device comprises a plurality of guide rails (1) and a rotating cage (2) moving along the length direction of the guide rails (1), wherein connecting pieces connected with the other guide rail (1) are arranged at two ends of the guide rails (1) in the length direction, the guide rails (1) comprise straight rails in a linear shape and arc rails in an arc shape, and a loop type runway (11) is assembled by the straight rails and the arc rails through the connecting pieces;

the rotating cage (2) comprises a containing cage (22) which is used for containing a mouse and is arranged in a hollow columnar structure and abutting edges (21) which are arranged on the outer side wall of the containing cage (22) and abutted to the guide rail (1), wherein the abutting edges (21) are provided with two abutting edges which are arranged in an annular structure, the guide rail (1) is provided with a guide groove (12) which is used for embedding the abutting edges (21) and has a guiding effect, the guide groove (12) extends in the extending direction of the guide rail (1), and the abutting edges (21) can move in the direction of the guide groove (12) when the mouse runs in the containing cage (22);

the rotating cage (2) and the guide rail (1) are both made of conductive materials, and one guide rail (1) is connected with a discharging device (18) for stimulating a white mouse;

running equipment is still including simulation equipment (3), simulation equipment (3) are including simulation shell (31) that are used for covering runway (11) and rotating cage (2) and set up the simulator that is used for simulating light source, temperature, humidity, wind-force in simulation shell (31), simulation shell (31) correspond a guide rail (1) position department and seted up shell opening (32) of placing rotating cage (2) on guide rail (1), simulation equipment (3) are still including shutoff shell (33) that are used for shutoff shell opening (32).

2. The running apparatus for mice as claimed in claim 1, wherein: the simulation shell (31) comprises a straight shell (311) used for covering the straight rail and an arc shell (312) used for covering the arc rail, and the straight shell (311) and the arc shell (312) respectively surround a cavity for the rotation cage to move with the straight rail and the arc rail.

3. The running apparatus for mice as claimed in claim 2, wherein: the runway (11), the simulation equipment (3) and the rotating cage (2) are respectively provided with two groups, the two runways (11) are arranged in an inner-outer ring structure, a shared track (4) is arranged on the two runways (11), the shared track (4) comprises a main track (41), two branch tracks (42) are respectively arranged at two ends of the main track (41) and are communicated with the rest parts of the two runways (11) through the branch tracks (42), guide grooves (12) which can respectively lead to the two branch tracks (42) are arranged on the main track (41), and direction changing devices (5) used for changing the moving direction of the rotating cage (2) are respectively arranged at an upper fork and a lower fork of the shared track (4);

the direction changing device (5) comprises a direction changing block (51) which plays a role in guiding the rotating cage (2) and a direction changing device (52) which drives the direction changing block (51) to rotate, one side, facing the guide rail (1), of the direction changing block (51) is provided with a fixed column (511) and a moving column (512), a fixed hole (15) through which the fixed column (511) passes and a moving chute (16) through which the moving column (512) slides are arranged on the guide rail (1), the moving chute (16) is arranged in an arc structure and extends along the width direction of the guide rail (1), the fixed hole (15) is positioned on one side of the main rail (41), the moving chute (16) is positioned on one side of the sub-rail (42), the direction changing device (52) comprises a moving plate (521) connected with the moving column (512) and a driving part (522) which drives the moving plate (521) to move, one side of the guide rail (1) is provided with a channel for the moving plate (521) to pass through and be connected with the moving column (512).

4. A mouse running device according to claim 3, wherein: the position of the housing opening (32) is located at the position of the main rail (41).

5. The running apparatus for mice as claimed in claim 1, wherein: and a tachometer (23) for recording the rotating speed of the rotating cage (2) is arranged at the center of the outer side wall of the abutting edge (21).

6. The running apparatus for mice as claimed in claim 1, wherein: the rotating cage (2) is made of an aluminum alloy material, and the guide rail (1) is made of an iron material.

7. The running apparatus for mice as claimed in claim 1, wherein: the dummy housing (31) is made of one-way glass whose interior can be seen only from the outside.

8. The running apparatus for white mice as claimed in claim 1, wherein: the abutting edges (21) are respectively arranged at two ends of the accommodating cage (22).