CN111323280A - Pretreatment method for determination of silicon element in fluorine-containing injection packaged by medicinal glass - Google Patents
Pretreatment method for determination of silicon element in fluorine-containing injection packaged by medicinal glass Download PDFInfo
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- CN111323280A CN111323280A CN202010224661.8A CN202010224661A CN111323280A CN 111323280 A CN111323280 A CN 111323280A CN 202010224661 A CN202010224661 A CN 202010224661A CN 111323280 A CN111323280 A CN 111323280A
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- fluorine
- silicon element
- medicinal glass
- pretreatment method
- containing injection
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- 229910052710 silicon Inorganic materials 0.000 title claims abstract description 26
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 title claims abstract description 25
- 239000010703 silicon Substances 0.000 title claims abstract description 25
- 239000011521 glass Substances 0.000 title claims abstract description 23
- 238000002347 injection Methods 0.000 title claims abstract description 21
- 239000007924 injection Substances 0.000 title claims abstract description 21
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 229910052731 fluorine Inorganic materials 0.000 title claims abstract description 16
- 239000011737 fluorine Substances 0.000 title claims abstract description 16
- 238000002203 pretreatment Methods 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 15
- 238000000120 microwave digestion Methods 0.000 claims abstract description 15
- 230000029087 digestion Effects 0.000 claims abstract description 13
- 239000012488 sample solution Substances 0.000 claims abstract description 9
- 229910017604 nitric acid Inorganic materials 0.000 claims description 9
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 7
- 238000005259 measurement Methods 0.000 claims description 7
- 229910021642 ultra pure water Inorganic materials 0.000 claims description 5
- 239000012498 ultrapure water Substances 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims 1
- 238000011084 recovery Methods 0.000 abstract description 10
- 239000002253 acid Substances 0.000 abstract description 6
- 239000000523 sample Substances 0.000 abstract description 5
- 239000012086 standard solution Substances 0.000 description 8
- 239000003814 drug Substances 0.000 description 6
- 238000001514 detection method Methods 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 229910002804 graphite Inorganic materials 0.000 description 3
- 239000010439 graphite Substances 0.000 description 3
- 229960005112 moxifloxacin hydrochloride Drugs 0.000 description 3
- IDIIJJHBXUESQI-DFIJPDEKSA-N moxifloxacin hydrochloride Chemical compound Cl.COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 IDIIJJHBXUESQI-DFIJPDEKSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000009616 inductively coupled plasma Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical group F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 229910052593 corundum Inorganic materials 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 239000012776 electronic material Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000004678 hydrides Chemical class 0.000 description 1
- 238000002354 inductively-coupled plasma atomic emission spectroscopy Methods 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229910001845 yogo sapphire Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
The invention discloses a pretreatment method for determining silicon element in a fluorine-containing injection packaged by medicinal glass. According to the pretreatment method for determining the silicon element in the fluorine-containing injection packaged by the medicinal glass, the sample is not stirred to be acid after being digested, but is cooled after being digested, and SiF can be treated in the process4Gas is absorbed into the sample solution again, and although the temperature in the microwave digestion process is very high, the digestion tank is closed in the whole digestion process, so that silicon loss is avoided, and the recovery rate is improved.
Description
Technical Field
The invention relates to the field of detection of medicinal glass, in particular to a pretreatment method for determination of silicon element in a fluorine-containing injection packaged by medicinal glass.
Background
The medicinal glass is one of the common materials for medicine packaging, and has the advantages of high barrier property, high temperature resistance, easy disinfection, recyclability, low cost and the like.
In recent years, the problem of "flaking" of medicinal glass has caused an event in which injections have been recalled. The compatibility problem exists between the injection and the medicinal glass, and the quality and the medication safety of the medicine can be ensured only by proper packaging materials. In 2015, the State food and drug administration and administration office published in the introduction of technical guidelines (trial) on compatibility research between chemical injections and pharmaceutical glass packaging containers, in which release of metal ions into pharmaceutical preparations is an important research item, while SiO is published2、B2O3And Al2O3As the main components of medicinal glasses, changes in the Si/B and Si/Al ratios may indicate the risk of glass flaking. Therefore, the Si concentration of the medicinal glass migrating to the injection must be accurately determined.
In the prior art, microwave digestion is adopted as a pretreatment method for silicon determination. Since the measurement range of element measurement instruments such as an Atomic Absorption Spectrophotometer (AAS) and an inductively coupled plasma emission spectrometer (ICP-OES) is in ultraviolet and visible light regions, most organic substances have ultraviolet absorption and interfere with the measurement result.
The microwave digestion process comprises the following steps: placing 2ml of sample into a microwave digestion tank, adding 7ml of nitric acid, carrying out 120-degree pre-digestion on an acid-dispelling device for 30 minutes, taking down, cooling, then digesting according to the operating program of the microwave digestion device, taking out after digestion, dispelling the acid at 120 degrees to 2-3ml, transferring to a 25ml volumetric flask, and carrying out constant volume to the scale with ultrapure water to be detected.
In the microwave digestion process, nitric acid is added for digestion, particles can be dissolved, organic matters can be destroyed, and elements to be detected with various valence states are oxidized into single high valence state or converted into inorganic compounds which are easy to decompose. Elemental silicon is easily lost in 3 forms: one is volatilization in the form of hydride; secondly, volatilizing in a fluoride form; thirdly, the precipitate is in the form of oxyacid. During the process of adding nitric acid to dissolve the glass-packaged fluorine-containing medicine, the glass is transferred to silicon dioxide of the medicine and the medicineFluorine of (2) reacts under acidic conditions to produce fluosilicic acid which is unstable and easily decomposed to SiF by heating4The gas escapes in the process of expelling acid, so that the recovery rate of silicon element is low.
Therefore, the technical personnel in the field are dedicated to develop a pretreatment method for measuring silicon element in the fluorine-containing injection packaged by medicinal glass, which can improve the recovery rate.
Disclosure of Invention
In view of the above-mentioned defects of the prior art, the present invention provides a pretreatment method for measuring silicon element in fluorine-containing injection packed in medicinal glass, which can improve the recovery rate.
In order to achieve the purpose, the invention provides a pretreatment method for determining silicon element in a fluorine-containing injection packaged by medicinal glass.
Preferably, the volume ratio of the sample solution to the nitric acid is 2: 5.
preferably, the volume ratio of the sample solution to the volumetric flask is 2: 50.
preferably, the digestion conditions are as follows: the pump speed was 50 rpm; the auxiliary gas flow is 0.5L/min; RF power is 1150W; the element wavelength is Si212.4nm.
Preferably, ultrapure water is used for constant volume to scale.
The invention has the beneficial effects that: according to the pretreatment method for determining the silicon element in the fluorine-containing injection packaged by the medicinal glass, the sample is not stirred to be acid after being digested, but is cooled after being digested, and SiF can be treated in the process4Gas is absorbed into the sample solution again, and although the temperature in the microwave digestion process is very high, the digestion tank is closed in the whole digestion process, so that silicon loss is avoided, and the recovery rate is improved. In addition, the acidity of the solution is too high due to no acid removal after digestion, the acidity in a spectrometer is high, the spectral line intensity is reduced, the stability of a measurement result is influenced, the acidity in a graphite furnace is high, a graphite tube is damaged, the service life of the graphite tube is shortened, and the volumetric flask is increasedThe volume is constant, so that the damage to instrument parts and the influence on the measurement result caused by too high acidity can be avoided.
Detailed Description
The present invention will be further described with reference to the following examples, wherein it is noted that the terms "upper", "lower", "left", "right", "inner", "outer", and the like, indicate orientations and positional relationships that are merely used to facilitate the description of the present invention and to simplify the description, but do not indicate or imply that the referenced devices or components must have a particular orientation, be constructed and operated in a particular manner, and therefore should not be construed as limiting the present invention. The terms "first," "second," "third," and the like are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Materials and instruments: nitric acid (Merck, batch No. K49249156729); the experimental water is prepared by a Millipore ultrapure water machine; standard solution of silicon (Si) GSB04-1752-2004(a) (national center for analysis and test of nonferrous metals and electronic materials, concentration 1000. mu.g/ml-1)。
Inductively coupled plasma emission spectrometer (thermofishericacap 7400); microwave digestion apparatus (CEM MARS 6).
Experimental methods
(1) Preparation of Standard solutions
Precisely transferring 0.5ml to 50ml of silicon element standard solution (1000 mu g/ml) into a volumetric flask, and adding 5% HNO3The solution was made to a constant volume of 50ml to obtain a silicon standard solution S having a concentration of 10. mu.g/ml1Taking S1In a 5.0ml to 50ml volumetric flask, a silicon standard solution S having a concentration of 1.0. mu.g/ml is obtained2Taking S2In a 5.0ml to 50ml volumetric flask, a silicon standard solution S having a concentration of 0.1. mu.g/ml is obtained3. The standard solutions are all mixed with 5% HNO3And preparing and diluting the solution. The linear series formulation method is shown in table 1.
TABLE 1 Standard solution concentrations and methods of preparation
(2) Preparation of test solution
In this example, a fluorine-containing sample moxifloxacin hydrochloride injection was tested, 2ml of moxifloxacin hydrochloride injection (batch: 170701) was precisely measured and placed in a microwave digestion tank, and 5ml of HNO was added3And after the reaction vessel is closed, digesting according to the operating program of the microwave digestion instrument, cooling after digestion, transferring the reaction vessel into a 50ml volumetric flask, and metering the volume to the scale by using ultrapure water to be measured.
(3) Preparation of spiked samples
Precisely measuring 2ml of moxifloxacin hydrochloride injection (batch number: 170701), and respectively precisely measuring S according to the prior art10.25ml, 0.5ml and 1.25ml (10 mu g/ml), and precisely measuring S according to the process of the invention1(10 mu g/ml)0.5ml, 1.0ml and 2.5ml, placing the mixture into a microwave digestion tank, digesting according to the method of preparing a test solution, and fixing the volume.
(4) Microwave digestion and detection conditions
TABLE 2 microwave digestion conditions of microwave digestion instrument
Wherein the pump speed is 50 rpm; the auxiliary gas flow is 0.5L/min; RF power is 1150W; the element wavelength is Si212.4nm;
measurement results
(1) Linear relation
The linear relationship of the Si element is shown in Table 3.
TABLE 3 Linear relationship
(2) Detection limit and quantification limit
A sample blank was taken, measured 11 times in a row, and the lowest detection limit (3SD) and lowest quantitation limit (10SD) were calculated from the Standard Deviation (SD) of the 11 concentration readings, and the experimental data are shown in table 4.
TABLE 4 lowest detection limit and quantitation limit
(3) Recovery rate
TABLE 5 comparative experimental results on recovery
The results of the prior art and the present invention recovery tests are shown in Table 5. It can be seen that in the prior art, the silicon recovery rate is less than 20%. In the invention, the recovery rate is between 96.12 and 101.74.
The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.
Claims (5)
1. A pretreatment method for determining silicon element in a fluorine-containing injection packaged by medicinal glass is characterized in that a sample solution is placed in a microwave digestion tank, nitric acid is added, digestion is carried out after sealing, cooling is carried out after digestion, the sample solution is transferred to a measuring flask after cooling, and the volume is fixed to the scale to obtain a sample solution.
2. The pretreatment method for measuring silicon element in a fluorine-containing injection packed in medicinal glass according to claim 1, wherein the volume ratio of the sample solution to nitric acid is 2: 5.
3. the pretreatment method for measuring silicon element in a fluorine-containing injection packed in medicinal glass according to claim 2, wherein the volume ratio of the sample solution to the volumetric flask is 2: 50.
4. the pretreatment method for measuring silicon element in the fluorine-containing injection packed in medicinal glass according to claim 1, wherein the digestion conditions are as follows: the pump speed was 50 rpm; the auxiliary gas flow is 0.5L/min; RF power is 1150W; the element wavelength is Si212.4nm.
5. The method for the pretreatment of measurement of silicon element in a fluorine-containing injection packed in medicinal glass according to claim 1, wherein ultrapure water is used when the volume is adjusted to the scale.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010224661.8A CN111323280A (en) | 2020-03-26 | 2020-03-26 | Pretreatment method for determination of silicon element in fluorine-containing injection packaged by medicinal glass |
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| CN202010224661.8A CN111323280A (en) | 2020-03-26 | 2020-03-26 | Pretreatment method for determination of silicon element in fluorine-containing injection packaged by medicinal glass |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114047176A (en) * | 2021-10-13 | 2022-02-15 | 重庆市食品药品检验检测研究院 | Method for detecting compatibility of white spirit glass packaging container |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050215764A1 (en) * | 2004-03-24 | 2005-09-29 | Tuszynski Jack A | Biological polymer with differently charged portions |
| WO2006104510A2 (en) * | 2004-08-20 | 2006-10-05 | Technology Innovations, Llc | Water-soluble compound |
| CN103940897A (en) * | 2014-05-13 | 2014-07-23 | 广州金域医学检验中心有限公司 | Method for determining traces of mercury, cadmium, lead and arsenic in food by inductively coupled plasma mass spectrometry (ICP-MS) |
| WO2014153570A2 (en) * | 2013-03-15 | 2014-09-25 | Transtar Group, Ltd | New and improved system for processing various chemicals and materials |
| CN106370510A (en) * | 2016-10-21 | 2017-02-01 | 天津大学 | Method for microwave digestion of glass body |
| CN107976356A (en) * | 2017-11-21 | 2018-05-01 | 天津泰达环保有限公司 | A kind of method of vitreum after micro-wave digestion plasma fusion |
| CN110006736A (en) * | 2019-03-07 | 2019-07-12 | 江阴兴澄特种钢铁有限公司 | The method that ICP-AES quickly measures Main elements aluminum oxide, silica and chromic oxide content in high alumina refractories containing chromium |
-
2020
- 2020-03-26 CN CN202010224661.8A patent/CN111323280A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050215764A1 (en) * | 2004-03-24 | 2005-09-29 | Tuszynski Jack A | Biological polymer with differently charged portions |
| WO2006104510A2 (en) * | 2004-08-20 | 2006-10-05 | Technology Innovations, Llc | Water-soluble compound |
| WO2014153570A2 (en) * | 2013-03-15 | 2014-09-25 | Transtar Group, Ltd | New and improved system for processing various chemicals and materials |
| CN103940897A (en) * | 2014-05-13 | 2014-07-23 | 广州金域医学检验中心有限公司 | Method for determining traces of mercury, cadmium, lead and arsenic in food by inductively coupled plasma mass spectrometry (ICP-MS) |
| CN106370510A (en) * | 2016-10-21 | 2017-02-01 | 天津大学 | Method for microwave digestion of glass body |
| CN107976356A (en) * | 2017-11-21 | 2018-05-01 | 天津泰达环保有限公司 | A kind of method of vitreum after micro-wave digestion plasma fusion |
| CN110006736A (en) * | 2019-03-07 | 2019-07-12 | 江阴兴澄特种钢铁有限公司 | The method that ICP-AES quickly measures Main elements aluminum oxide, silica and chromic oxide content in high alumina refractories containing chromium |
Non-Patent Citations (3)
| Title |
|---|
| 孙大赢等: "微波消解-ICP-MS测定黄明胶中6种有害元素", 《中国现代应用药学》 * |
| 段雪梅: "微波王水消解不赶酸原子荧光光谱法测定土壤中的砷", 《分析测试技术与仪器》 * |
| 王君等: "微波消解-电感耦合等离子体发射光谱法测定明胶中铬含量", 《食品研究与开发》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114047176A (en) * | 2021-10-13 | 2022-02-15 | 重庆市食品药品检验检测研究院 | Method for detecting compatibility of white spirit glass packaging container |
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Application publication date: 20200623 |