CN111312396B - Individual alcohol content assessment method and system based on alcohol content related factors - Google Patents
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- 238000000034 method Methods 0.000 title claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims description 30
- 235000014101 wine Nutrition 0.000 claims abstract description 48
- 230000035622 drinking Effects 0.000 claims abstract description 37
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- 101710185492 Acetaldehyde dehydrogenase 2 Proteins 0.000 claims description 12
- 101710185511 Acetaldehyde dehydrogenase 3 Proteins 0.000 claims description 12
- 108010081577 aldehyde dehydrogenase (NAD(P)+) Proteins 0.000 claims description 6
- 230000037396 body weight Effects 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 5
- 238000004364 calculation method Methods 0.000 claims 2
- 208000007848 Alcoholism Diseases 0.000 description 3
- 201000007930 alcohol dependence Diseases 0.000 description 3
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Abstract
An individual wine amount evaluation method and system based on wine amount related factors, wherein the method comprises the following steps: 1) Collecting personal information and genetic information of an evaluated person, wherein the personal information comprises input items such as age, sex, weight, height and the like, 2) carrying out wine amount according to the input personal information, and gene coefficients and metabolic formulas corresponding to the genetic informationfIs calculated by the computer. The system comprises an input module, an algorithm module and an output module; the input module is used for inputting the collected personal information and genetic information of the evaluated person; the algorithm module is used for carrying out wine volume according to the input personal information, the genetic coefficient corresponding to the genetic information and the metabolism formulafThe output module is used for calculating the wine amountfAnd outputting the set EBAC score and the drinking time as a result.
Description
Technical Field
The invention relates to a method and a system for evaluating wine volume.
Background
The history of Chinese wine making is of great origin, and among many wines, white spirit is taken as the main wine for Chinese people to drink. Accident investigation by the World Health Organization (WHO) shows that about 50% -60% of traffic accidents are related to drunk driving, which is the leading cause of mortality for car accidents. The number of people dying from alcoholism in China is over 11 ten thousand per year, and accounts for 1.3% of the total mortality rate. There are hundreds of thousands of traffic accidents each year due to drunk driving, of which more than half of the deaths are related to drunk driving. Meanwhile, long-term drinking can increase the risk of cardiovascular and cerebrovascular diseases, and is also a high-risk factor for the onset of some tumors. China has long been listed by the world health organization as a "disaster area" for world alcohol consumption, and the health costs paid in the back are difficult to measure.
The existing studies have pointed out that SNP sites of a plurality of human genes including SNP site rs1229984 on ADH1B (acetaldehyde dehydrogenase 1B), SNP site rs671 on ALDH2 (acetaldehyde dehydrogenase 2), and SNP site rs698 on ALDH3 (acetaldehyde dehydrogenase 3) may be closely related to alcohol metabolism ability of human body, but sites related to alcohol metabolism ability are not only three or more, and the wine amount is affected by various factors and individuals vary greatly, and it is difficult to predict the wine amount in advance simply to detect genotype of SNP site. The existing alcohol content assessment methods are rough, only the variety of alcohol or personal life information of drinkers is concerned, or only the alcohol metabolism related genes of individuals are concerned, the assessment methods are not comprehensive enough, the alcohol metabolism capability and the alcohol content (namely the actual tolerance to alcoholic drinks) of a single individual cannot be accurately reflected, and besides 'in-person alcohol test', no method for estimating the alcohol content of people in advance exists, abuse of alcohol is avoided through the estimated alcohol content, and various health problems caused by alcohol drinking are prevented.
Disclosure of Invention
In order to solve the technical problems, the invention adopts the following technical scheme:
an individual wine amount evaluation method based on a wine amount related factor, comprising the steps of:
1) Collecting personal information and genetic information of an evaluated person, wherein the personal information comprises input items of age, sex, weight, height and the like,
the genetic information comprises genotype detection results of SNP locus rs1229984 on ADH1B (acetaldehyde dehydrogenase 1B), SNP locus rs671 on ALDH2 (acetaldehyde dehydrogenase 2) and SNP locus rs698 on ALDH3 (acetaldehyde dehydrogenase 3), different gene coefficients and applicable metabolic formulas are set for different genotype combinations, and the corresponding relation between the genotypes and the gene coefficients x and the applicable metabolic formulas is shown in the following table
2) Alcohol content according to the personal information, genetic coefficient and metabolism formulaIs calculated by (1) the wine quantity->Is calculated as follows:
wherein:
(1) When the input of the sex input item is male,i=1; the input content is a female person, and the input content is a female person,i=0；
（2）k 1 =11.9934；k 0 =10.1323；
（3）F tj in order to be a metabolic formula,jthe value of (2) is 1 or 2;
t is the drinking time, and the unit ish；
(4) x is a gene coefficient;
（5）W ti is a physical parameter in which:
W t is body weight in kg; h is height, and the unit is cm; age is age, unit is age, wine volumefUnits of (2)The alcohol content of the wine is calculated as 53% (v/v) in ml;
EBAC is drunk state score, and the corresponding relationship between EBAC score and drinker state is shown in the following table
。
The individual drinking amount evaluation method based on the drinking amount related factors further comprises the step of presetting the drinking time and the EBAC value representing the drinking state.
The invention also provides an individual wine amount evaluation system based on the related factors of the wine amount, which comprises an input module, an algorithm module and an output module;
the input module is used for inputting the acquired personal information and genetic information of the person to be evaluated, wherein the personal information comprises input items such as age, gender, weight, height and the like;
the genetic information comprises genotype detection results of SNP locus rs1229984 on ADH1B (acetaldehyde dehydrogenase 1B), SNP locus rs671 on ALDH2 (acetaldehyde dehydrogenase 2) and SNP locus rs698 on ALDH3 (acetaldehyde dehydrogenase 3), different gene coefficients and applicable metabolic formulas are set for different genotype combinations, and the corresponding relation between the genotypes and the gene coefficients x and the applicable metabolic formulas is shown in the following table
；
The algorithm module is used for carrying out wine volume according to the input personal information, the genetic coefficient corresponding to the genetic information and the metabolism formulaIs calculated by (1) the wine quantity->Is calculated as follows:
wherein:
(1) When the input of the sex input item is male,i=1; the input content is a female person, and the input content is a female person,i=0；
（2）k 1 =11.9934；k 0 =10.1323；
（3）F tj in order to be a metabolic formula,jthe value of (2) is 1 or 2;
t is the drinking time, and the unit ish；
(4) x is a gene coefficient;
（5）W ti is a physical parameter in which:
W t is body weight in kg; h is height, and the unit is cm; age is age, unit is age, wine volumefIn ml, the alcohol content of said wine being calculated as 53% (v/v);
EBAC is a drunkenness state score, the drinking time is set at the beginning of evaluation, and the EBAC value is set according to the target drunkenness state, and the corresponding relation between the EBAC score and the drinker state is shown in the table below
The output module is used for measuring the wine volumefAnd outputting the set EBAC score and the drinking time as a result.
Compared with the prior art, the invention has the advantages that by utilizing the sex, age, weight, height, genetic information, set drinking time and drinking state score of the individual, a drinking amount evaluation method capable of accurately evaluating the drinking amount of the individual and simulating the corresponding relation between the drinking amount and the drinking state of various individuals according to the model is established, and a drinking amount evaluation system is provided based on the method. Through verification, the method can accurately estimate the wine amount of the user. Thereby helping individuals to prevent alcoholism and controlling drinking amount.
Drawings
FIG. 1 is a system architecture diagram of an individual wine level assessment system based on wine level related factors in accordance with the present invention.
Detailed Description
An individual wine amount evaluation system based on the related factors of the wine amount comprises an input module, an algorithm module and an input module, wherein the system architecture is shown in figure 1.
The input module is used for inputting the acquired personal information and genetic information of the person to be evaluated, wherein the personal information comprises input items such as age, gender, weight, height and the like;
the genetic information comprises genotype detection results of SNP locus rs1229984 on ADH1B (acetaldehyde dehydrogenase 1B), SNP locus rs671 on ALDH2 (acetaldehyde dehydrogenase 2) and SNP locus rs698 on ALDH3 (acetaldehyde dehydrogenase 3), different gene coefficients and applicable metabolic formulas are set for different genotype combinations, and the corresponding relation between the genotypes and the gene coefficients x and the applicable metabolic formulas is shown in the following table
；
The algorithm module is used for carrying out wine volume according to the input personal information, the genetic coefficient corresponding to the genetic information and the metabolism formulaIs calculated by (1) the wine quantity->Is calculated as follows:
wherein:
(1) When the input value of the sex input item is male,i=1; when the input value is a female one,i=0；
（2）k 1 =11.9934；k 0 =10.1323；
（3）F tj in order to be a metabolic formula,jthe value of (2) is 1 or 2;
t is the drinking time, and the unit ish；
(4) x is a gene coefficient;
（5）W ti is a physical parameter in which:
W t is body weight in kg; h is height, and the unit is cm; age is age, unit is age, wine volumefIn ml, the alcohol content of said wine being calculated as 53% (v/v);
EBAC is a drunkenness state score, the drinking time is set at the beginning of evaluation, and the EBAC value is set according to the target drunkenness state, and the corresponding relation between the EBAC score and the drinker state is shown in the table below
；
The output module is used for calculating the drinking amount under the set drinking time period and the set target drinking state (characterized by EBAC value)fOutput as a result, together with the wine volumefThe corresponding drinking time and the target drinking state are also output as the result.
Example 1: the individual alcohol content evaluation system based on the alcohol content related factors provided by the invention is used for evaluating the alcohol content of a drinker and comparing the alcohol content with the alcohol content measured by actual drinking
The number of persons 10 who were practised, the length of drinking 1h, and the status of stumbling after drinking (EBAC 0.15) as terminated, are given in the following table:
the SPSS16.0 software is adopted to perform t-test on the estimated and actual wine amount to obtain P=0.157 (pair-wise test, double-tail distribution), and the statistical difference is not provided, so that the wine amount estimation system has accurate estimation result, can reflect the actual wine amount of an individual, can help the individual to know alcohol metabolism capability, and can prevent health hazard caused by alcohol such as alcoholism.
Claims (3)
1. An individual wine capacity assessment method based on related factors of wine capacity is characterized by comprising the following steps of
1) Collecting personal information and genetic information of an evaluated person, wherein the personal information comprises age, sex, weight and height input items,
the genetic information comprises genotype detection results of SNP locus rs1229984 on ADH1B (acetaldehyde dehydrogenase 1B), SNP locus rs671 on ALDH2 (acetaldehyde dehydrogenase 2) and SNP locus rs698 on ALDH3 (acetaldehyde dehydrogenase 3), different gene coefficients and applicable metabolic formulas are set for different genotype combinations, and the corresponding relation between the genotypes and the gene coefficients x and the applicable metabolic formulas is shown in the following table
2) According to the input personal information, and the gene coefficient and the metabolism formula corresponding to the genetic information, calculating the wine quantity f, wherein the calculation of the wine quantity f is as follows:
f＝k i *(EBAC+F tj *x*10 -3 )*W ti
wherein:
(1) When the input of the sex input item is male, i=1; input content is female, i=0;
(2)k 1 ＝11.9934；k 0 ＝10.1323；
(3)F tj the value of j is 1 or 2 for the metabolic formula;
F t1 ＝-0.03274t 5 +0.9252t 4 -10.0217t 3 +48.9265t 2 -72.796t+32.9988；
F t2 ＝-0.1956t 3 -0.9263t 2 +65.056t+1.0659
t is the drinking time, and the unit is h;
(4) x is a gene coefficient;
(5)W ti is a physical parameter in which:
W t is body weight in kg; h is height, and the unit is cm; age is age, the unit of wine quantity f is ml, and the alcohol content of the wine is calculated by 53% v/v;
EBAC is drunk state score, and the corresponding relationship between EBAC score and drinker state is shown in the following table
。
2. The individual drinking amount evaluation method based on the drinking amount related factors as set forth in claim 1, further wherein the drinking time period and the EBAC value indicating the drinking state can be set in advance.
3. An individual wine amount evaluation system based on related factors of wine amount is characterized by comprising an input module, an algorithm module and an output module;
the input module is used for inputting the collected personal information and genetic information of the person to be evaluated, wherein the personal information comprises age, gender, weight and height input items;
the genetic information comprises genotype detection results of SNP locus rs1229984 on ADH1B (acetaldehyde dehydrogenase 1B), SNP locus rs671 on ALDH2 (acetaldehyde dehydrogenase 2) and SNP locus rs698 on ALDH3 (acetaldehyde dehydrogenase 3), different gene coefficients and applicable metabolic formulas are set for different genotype combinations, and the corresponding relation between the genotypes and the gene coefficients x and the applicable metabolic formulas is shown in the following table
The algorithm module is used for calculating the wine quantity f according to the input personal information, the genetic coefficient corresponding to the genetic information and the metabolism formula, and the calculation of the wine quantity f is as follows:
f＝k i *(EBAC+F tj *x*10 -3 )*W ti
wherein:
(1) When the input of the sex input item is male, i=1; input content is female, i=0;
(2)k 1 ＝11.9934；k 0 ＝10.1323；
(3)F tj the value of j is 1 or 2 for the metabolic formula;
F t1 ＝-0.03274t 5 +0.9252t 4 -10.0217t 3 +48.9265t 2 -72.796t+32.9988；
F t2 ＝-0.1956t 3 -0.9263t 2 +65.056t+1.0659
t is the drinking time, and the unit is h;
(4) x is a gene coefficient;
(5)W ti is a physical parameter in which:
W t is body weight in kg; h is height, and the unit is cm; age is age, the unit of wine quantity f is ml, and the alcohol content of the wine is calculated by 53% v/v;
EBAC is a drunkenness state score, the drinking time is set at the beginning of evaluation, and the EBAC value is set according to the target drunkenness state, and the corresponding relation between the EBAC score and the drinker state is shown in the table below
The output module is used for outputting the wine quantity f as a result and outputting the set EBAC score and the set drinking time.
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| CN112102920B (en) * | 2020-07-30 | 2023-11-10 | 苏州因顿医学检验实验室有限公司 | Drinking volume prediction system based on gene screening |
| CN112037855B (en) * | 2020-07-30 | 2023-09-12 | 苏州因顿医学检验实验室有限公司 | Drinking volume prediction method based on gene screening |
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