CN111298682A

CN111298682A - Processing device for mixture in colloidal form

Info

Publication number: CN111298682A
Application number: CN202010266574.9A
Authority: CN
Inventors: 付志强
Original assignee: Hangzhou Jinggangren Health Technology Co Ltd
Current assignee: Hangzhou Jinggangren Health Technology Co Ltd
Priority date: 2020-04-08
Filing date: 2020-04-08
Publication date: 2020-06-19

Abstract

The invention relates to the field of processing of drugs or mixtures in colloidal forms, and discloses a processing device for a mixture in colloidal form. The invention has the advantages that the stirring time can be reduced as much as possible, and the invention is particularly suitable for mixtures with larger form difference in some mixed components, for example, the mixtures with obviously less effective components, and has higher application value.

Description

Processing device for mixture in colloidal form

Technical Field

The invention relates to the field of processing of colloidal drugs or mixtures, in particular to a processing device for colloidal mixtures.

Background

During the manufacturing of pharmaceutical products, particularly for the manufacture of topical paste-like pharmaceutical products, it is often desirable to achieve a uniform dispersion of the drug in the matrix. The prior art homogenizes the paste by stirring to form a colloid, thereby achieving the purpose of homogenization. However, excessive homogeneity also affects the structure and stability of the colloid. For this reason, it is necessary to develop a device and corresponding steps which make it possible to optimize the stirring time with the greatest possible retention of the colloidal structure.

Disclosure of Invention

Aiming at the defect that the stirring time of the mixture in the colloidal state is too long and the colloid structure is easy to change in the prior art, the invention provides a processing device for the mixture in the colloidal state.

In order to achieve the purpose, the invention can adopt the following technical scheme:

a processing device for a mixture in a colloidal form comprises a container, a stirring device and a measuring device array; wherein the content of the first and second substances,

the container is used for containing a mixture in a jelly form, the stirring device is arranged in the container, and the measuring device array comprises at least 2 groups of measuring groups; the measurement group comprises at least 3 measurement devices which are uniformly spaced from each other; wherein the content of the first and second substances,

the distance between each measuring device in the same group and the stirring device is the same; different measurement groups are arranged at intervals along the direction far away from the stirring device; the measuring device is reciprocated along a predetermined direction.

Further, as an optional scheme, in the embodiment of the present application, the method further includes the following specific steps:

starting the stirring device; continuously recording detection data of the measuring device array in a uniformly spaced time period until the detection data reach a first preset value range, and starting the measuring device array to move back and forth along the preset direction; and continuously recording the detection data of the measuring device array in a uniformly spaced time period until the detection data reaches a second preset value range, and then stopping the stirring device.

Further, as an alternative, in the embodiment of the present application, the predetermined direction refers to a direction from the container opening position toward the container interior.

Further, as an optional solution, in an embodiment of the present application, the first predetermined value range and the second predetermined value range respectively include an interval time and a period length.

Further, as an optional solution, in an embodiment of the present application, the first predetermined value range further includes a mean value of data measured by all the measuring devices in the same time period.

Further, as an optional solution, in an embodiment of the present application, the first predetermined value range further includes a difference between data measured by measurement devices in different measurement groups in the same time period.

Further, as an optional solution, in an embodiment of the present application, the first predetermined value range further includes a difference value of data measured by all the measuring devices in different time periods.

Further, as an alternative, in the embodiment of the present application, after the stirring device is stopped, the second predetermined value range is taken as the first predetermined value range.

Further, as an alternative, in an embodiment of the present application, the measuring device includes a temperature measuring device.

Further, as an optional solution, in the embodiment of the present application, a heating device disposed in the container is further included.

The invention has the following remarkable technical effects:

the stirring time can be reduced as much as possible, and the method is particularly suitable for mixtures with larger morphological differences in some mixed components, for example, mixtures with significantly less active ingredients.

Drawings

Fig. 1 is a schematic configuration diagram of a processing apparatus according to an embodiment.

Fig. 2 is a schematic configuration diagram of a processing apparatus according to embodiment 3.

Fig. 3 is a diagram showing a procedure of using the processing apparatus.

Detailed Description

The present invention will be described in further detail with reference to examples.

Example 1

As shown in fig. 1, a processing device for a mixture in a gel form includes a container 101, a stirring device 102, and a measurement array 103. The measuring device 105 may be one or any one of the temperature measuring device 105, the resistance measuring device 105, or the pressure measuring device 105, and the temperature measuring device 105, the resistance measuring device 105, or the pressure measuring device 105 may be any one of devices or structures that are available. The stirring device 102 is typically a paddle stirring device, and the maximum diameter is the diameter of the stirring device. The container 101 may be of any conventional construction or material,container with double-layer structure。

The container 101 is used to contain a mixture in a gel form, where the gel may be formed by the additional addition of a filler that may form a gel form, or a gel formed by the substance released by the drug itself. The colloid, jelly and jelly forms described in the application all refer to uniform dispersion systems, but in the mixing and processing process, the colloid is not uniform, and the uniformity degree of the dispersion of materials and components in the final jelly can be different according to the processing requirements. The stirring device 102 is arranged in the container 101, the stirring device 102 used is of an existing structure, and the measurement array 103 comprises at least 2 measurement groups 104; the measurement group 104 comprises at least 3 measurement devices 105 evenly spaced from each other; each measuring device 105 in the same group has the same distance from the stirring device 102, and is arranged around the stirring device 102, and the stirring device 102 needs to have a certain distance to ensure that the stirring does not directly cause errors and interference on the measuring results of the measuring devices 105; the different measurement sets are spaced apart in a direction away from the stirring device 102, and are typically arranged in a circular array of different sizes; the measuring device 105 is reciprocally movable along a predetermined direction 201, the predetermined direction 201 being a direction from the opening position of the container 101 toward the inside of the container 101, and is generally a vertical direction. However, in practice, the predetermined direction 201 may be other directions, such as horizontal, which is advantageous for reducing the influence of mixture stratification on the measurement, as described in other embodiments of the present application.

As shown in fig. 3, the mixing device according to the present application further includes the following step a:

starting the stirring device 102; after continuously recording the detection data of the measurement array 103 in uniformly spaced time periods until the detection data reaches a first predetermined value range, the detection data may select the average value of all the detection devices, and start the measurement array 103 to reciprocate along the predetermined direction 201; the recording of the test data of the measurement array 103 is continued for a period of time at regular intervals until the test data reaches a second predetermined range of values before the stirring device 102 is stopped. It should be noted that the operation time of the stirring device 102 described in step a is only a part of the whole stirring process.In addition, of the stirring device 102 The position of the blade has two options of high and low, and is generally based on the viscosity of the mixture in a gelatinous state after expected stirring The adjustment is made to anticipate a high consistency mixture with the paddles in a lower position and vice versa in a high position.

The uniform interval until the first predetermined value is reached is typically 5-20 minutes, but for improved accuracy, the interval is typically calculated using the following method, as a more preferred option:

wherein a is a constant coefficient and can be adjusted according to actual conditions, but the adjustment range is preferably 0.1-0.5, the viscosity of the mixture is an ideal value, and the viscosity of the mixture after uniform mixing is generally replaced by the viscosity of the matrix when the mass of the added materials is within 5% of the mass of the matrix, otherwise, the parameter coefficient b can be used for adjustment, and the value of b is 1-50. The rotation speed is in circles per minute, the diameter is in centimeters, the volume of the container is in liters, the height is in centimeters, and the viscosity is generally obtained at room temperature, i.e., 20 ℃. For example,

the detection data is calculated according to 5 parameters, namely a) interval time, b) time period length, c) average value of data measured by all measuring devices 105 in the same time period, d) difference value of data measured by the measuring devices 105 in different measuring groups 104 in the same time period, and e) difference value of data measured by all measuring devices 105 in different time periods. Wherein c), d) and e) can be replaced with each other, mainly considering the application of different measuring devices. Thus, the detection data can be calculated in the following manner:

b1 represents the difference between the data measured by the measuring devices 105 in different measuring groups 104 in the same time period, and one measuring device 105 is arbitrarily selected and measured in different measuring groups 104, and the difference between every two measuring devices is averaged, or any two measuring devices are selected and averaged after the measured values of all measuring devices in different measuring groups 104 are averaged; b2 represents the difference between the measured data of different measuring devices 105 in the same measuring group 104 in different time periods, and it is usually determined by selecting the measuring group 104 arbitrarily or selecting the measuring group 104 containing a larger number of measuring devices 105, and averaging the difference values to obtain the difference value. Wherein a is a constant parameter, and is generally between 1.1 and 1.6.

Specifically, the following array arrangement may be adopted: taking a stirring shaft of the stirring device as a center, and a measuring group A is closest to the stirring shaft 107 and comprises 5 temperature measuring devices 105 which are uniformly spaced around the stirring shaft, wherein the distance between the measuring devices 105 and the stirring shaft 107 in the measuring group A is 12 cm; arranged radially outside the measurement group a is a measurement group B which comprises 10 temperature measuring devices 105 surrounding the outside of the measurement group a, the distance between the measuring devices 105 of the measurement group B and the stirring shaft 107 being 28 cm. When the length of the time period until the first predetermined value was reached was taken as 20 minutes, the measurement result at 0 minute was recorded as a0, the data measured at 7.9 minutes was recorded as a1, and the data measured at 10.7 minutes was recorded as a 2. The measurement was performed with the measurement device a1 in measurement group a, the measurement was performed with the measurement device B6 in measurement group B, and the difference was taken to be 0.3 ℃ as B1, or the average of the measurements for measurement group a — the average of the measurement value zones for measurement group B was 0.29 ℃ as B1.

During specific measurement, the range of the first predicted value is set to be between 100 and 150, and after the detection data reaches the range, the detection data is shown to reach the rangeA first prediction value range.

The second predetermined value range is 90% ± 10% of the first predetermined value range. When the detection data again falls within the second predetermined value range, indicating that the detection data reaches the second predetermined value range, the stirring may be stopped.

Example 2

On the basis of the devices and steps described in the embodiments, an additional heating device 106 may be included for the thermometry device, and the heating device 106 functions to reduce the influence of the change in the ambient temperature on the measurement.As an option Comprises at least 3 heating devices 106 respectively arranged at the inner bottom of the container 101 and opposite to the inner side wall In the two side positions.

The following step B is also generally included:

setting a preset heating temperature and preset heating time, executing the step A, recording the stirring rotating speed, the diameter of the stirring device and the stirring time, comparing the parameters with corresponding parameters which do not adopt additional preheating, adjusting the preset heating temperature and the preset heating time according to the comparison result until the difference between the parameters is extremely small, and taking the heating temperature and the heating time under the result as the preset value of the heating device.

Example 3

As shown in fig. 2, on the basis of the apparatuses and steps described in embodiment 1 or 2, a plurality of second measurement apparatuses 205 arranged horizontally may be further included, the second measurement apparatuses 205 at the same horizontal position form a second measurement group 204, and the second measurement groups 204 at different horizontal positions combine the second measurement array 203.

The second measuring device 205 is moved back and forth along a second predetermined direction, which is arbitrarily designated for convenience, and may be arranged in a ring-shaped radial manner for more accurate measurement, but the final measurement results are not very different based on step a. Further, in the case where the second measurement array 203 is provided, the measurement array 103 may be simplified, and only one set of measurement sets 104 may be left in the measurement array 103, while the accuracy of measurement may be improved. Measurements for the second measurement array 203 may be referenced to the measurement array 103.

In summary, the above-mentioned embodiments are only preferred embodiments of the present invention, and all equivalent changes and modifications made in the claims of the present invention should be covered by the claims of the present invention.

Claims

1. A device for processing a mixture in a gelatinous form, comprising a container (101), a stirring device (102), a measuring array (103); wherein the content of the first and second substances,

the container (101) is used for containing a mixture in a colloidal form, the stirring device (102) is arranged in the container (101), and the measurement array (103) comprises at least 2 measurement groups (104); the measurement group (104) comprises at least 3 measurement devices (105) which are evenly spaced from each other; wherein each measuring device (105) within the same group is at the same distance from the stirring device (102); different measurement groups are arranged at intervals along the direction far away from the stirring device (102); the measuring device (105) is moved back and forth along a predetermined direction (201).

2. The apparatus for processing a mixture in colloidal form according to claim 1, characterized in that it comprises the following specific steps:

starting the stirring device (102); continuously recording detection data of the measurement array (103) in uniformly spaced time periods until the detection data reaches a first preset value range, and starting the measurement array (103) to move back and forth along the preset direction (201); the detection data of the measuring array (103) are continuously recorded in evenly spaced time periods until the stirring device (102) is stopped after the detection data reaches a second predetermined value range.

3. Device for processing a mixture in colloidal form according to claim 1, characterized in that said predetermined direction (201) is the direction from the position of the opening of the container (101) towards the inside of the container (101).

4. The apparatus for processing a mixture in a gelatinous state as set forth in claim 2, wherein said first predetermined range of values and said second predetermined range of values include interval time and period length, respectively.

5. Device for processing a mixture in a gelatinous form according to claim 2 or 4, characterised in that the first predetermined range of values also includes the mean value of the data measured by all measuring devices (105) over the same period of time.

6. Device for processing a mixture in colloidal form according to claim 2 or 4, characterized in that said first predetermined range of values also comprises the difference of the data measured by the measuring devices (105) of different measuring groups (104) during the same time period.

7. The apparatus for processing a mixture in colloidal form according to claim 2 or 4, characterized in that said first predetermined range of values also comprises the difference of the data measured by all the measuring means (105) over different periods of time.

8. Device for processing a mixture in colloidal form according to claim 2, characterized in that the second predetermined value range is taken as the first predetermined value range after stopping the stirring means (102).

9. Device for processing a mixture in colloidal form according to claim 1, characterized in that said measuring means (105) comprise temperature measuring means (105).

10. Device for processing a mixture in colloidal form according to claim 9, characterized in that it also comprises heating means (106) arranged inside said container (101).