CN111269437A - Preparation method of composite hydrogel with self-healing property and adhesion property - Google Patents
Preparation method of composite hydrogel with self-healing property and adhesion property Download PDFInfo
- Publication number
- CN111269437A CN111269437A CN201911245875.7A CN201911245875A CN111269437A CN 111269437 A CN111269437 A CN 111269437A CN 201911245875 A CN201911245875 A CN 201911245875A CN 111269437 A CN111269437 A CN 111269437A
- Authority
- CN
- China
- Prior art keywords
- solution
- hydrogel
- glucomannan
- composite hydrogel
- self
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D179/00—Coating compositions based on macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen, with or without oxygen, or carbon only, not provided for in groups C09D161/00 - C09D177/00
- C09D179/04—Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2405/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2401/00 or C08J2403/00
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2479/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen, or carbon only, not provided for in groups C08J2461/00 - C08J2477/00
- C08J2479/04—Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a preparation method of composite hydrogel with self-healing property and adhesion property. First, hydroxybutyl chitosan was synthesized by a known method (patent No. zl201110214776. x). And secondly, oxidizing and modifying the natural glucomannan to obtain oxidized glucomannan with aldehyde group. Dissolving hydroxybutyl chitosan and oxidized glucomannan in deionized water, and uniformly mixing the hydroxybutyl chitosan solution and the oxidized glucomannan solution under the condition of low-temperature stirring to obtain the hydrogel. The network of the hydrogel is constructed by Schiff base bonds formed by amino and aldehyde groups, which are dynamic chains that can be broken and reformed, thereby making the hydrogel self-healing. And adding the dopamine solution to the surface of the composite hydrogel to form a polydopamine coating to obtain the composite hydrogel. Dopamine contains catechol groups, and endows the composite hydrogel with good adhesiveness. The composite hydrogel material has self-healing property and adhesiveness, and may have wide application prospect in tissue engineering and skin repair.
Description
Technical Field
The invention relates to the technical field of medical materials, in particular to a preparation method of composite hydrogel with self-healing property and adhesion property.
Background
The macromolecular hydrogel is a transparent or semitransparent viscoelastic semi-solid flexible biomaterial, has low macromolecular content and most water content, and has wide application value in the biomedical fields of tissue engineering, slow-release carriers and the like. However, the traditional high-molecular hydrogel material has no self-healing function and is difficult to repair once damaged. And the tissue adhesiveness is poor, so that the ideal medical hydrogel material applied to wounds and damaged tissues has certain self-healing capability after being damaged and good adhesiveness.
The chitosan is a derivative of chitosan after deacetylation, is a natural cationic polymer, and has good biological properties such as biocompatibility, biodegradability, bioactivity and the like. As a large number of amino groups and hydroxyl groups are distributed on the molecular chain of the chitosan, intramolecular and intermolecular hydrogen bonds can be formed, so that the chitosan is hardly dissolved in water or alkaline solution, and the application of the chitosan in a neutral environment in vivo is limited. The hydroxybutyl modified chitosan has good water solubility, effectively improves the limitation that the hydroxybutyl chitosan can only be dissolved in an acid solution, but has poor mechanical strength on the basis of hydrogen bond and hydrophobic effect, and limits the application of the hydroxybutyl chitosan. Glucomannan (KGM) has excellent biodegradability and biocompatibility, however, KGM has a very large molecular weight, strong water absorption, high swelling degree, and poor water solubility and rheology, which limits its wide application. The modification of KGM mainly comprises blending, graft copolymerization, esterification and oxidation. Oxidized glucomannan is obtained by oxidizing glucomannan, and has the advantages of biodegradability, good biocompatibility and the like. The aldehyde group of the oxidized glucomannan can generate Schiff base reaction with the amino group of the hydroxybutyl chitosan to form a dynamic covalent bond Schiff base bond, thereby endowing the hydrogel with self-healing property. And meanwhile, the mechanical strength of the hydrogel is improved due to covalent bond crosslinking. Inspired by the capability of mussels in the sea to adhere to rocks, a dopamine solution is coated on the surface of the hydrogel to form a polydopamine coating, and dopamine contains catechol groups and can endow the composite hydrogel with certain adhesiveness.
The invention aims to provide a preparation method of composite hydrogel with self-healing and adhesion properties.
Disclosure of Invention
The technical scheme adopted by the invention specifically comprises the following steps:
(1) preparation method of hydroxybutyl chitosan (refer to patent CN201110214776. X)
(2) The oxidized glucomannan is prepared by the following method: weighing glucomannan (KGM) powder, placing the powder into deionized water, and stirring for dissolving; weighing sodium periodate, adding the sodium periodate into the obtained KGM solution, and stirring the mixture at room temperature in a dark place for reaction for 6 to 12 hours; dialyzing, and freeze-drying to obtain the oxidized glucomannan
(3) Dopamine is dissolved in Tris-HCl buffer (10mM, pH8.5) at a concentration of 0.05-1%
(4) Dissolving hydroxybutyl chitosan and oxidized glucomannan in deionized water at low temperature, dissolving dopamine hydrochloride in Tris-HCl buffer solution (10mM, pH8.5), and fully and uniformly mixing the obtained hydroxybutyl chitosan (HBC) solution and oxidized glucomannan (OKGM) solution (the mass ratio of hydroxybutyl chitosan to oxidized glucomannan is 1-20: 1) to obtain the hydrogel. And adding the dopamine solution to the surface of the hydrogel to form a polydopamine coating, and coating for 10-180min to obtain the composite hydrogel with self-healing property and adhesion.
Detailed Description
The present invention will be further described with reference to the following examples, but the present invention is not limited to the following examples.
Example 1:
1. the preparation of HBC is made by the prior art (refer to patent cn201110214776. x), and the procedure is as follows:
weighing 4 g of chitosan powder, dispersing the chitosan powder in 50 mL of 50 wt% NaOH solution for alkalization, stirring the mixture for 24 hours at room temperature, and extruding redundant alkali liquor to obtain a solid matter; adding the obtained solid into 80 mL of 75 wt% isopropanol aqueous solution, and stirring for 24h until the alkalized chitosan is completely dispersed in an isopropanol-water system; weighing 80 mL of 1, 2-epoxybutane, dropwise adding into a reaction container, and reacting for 24 hours at 55 ℃; after the reaction is finished, cooling the reaction liquid to room temperature, and dropwise adding an HCl solution into the reaction liquid to adjust the pH value of the system to be neutral; dialyzing the obtained product in a dialysis bag, and dialyzing with running water for 3 days by pure water for 3 days; after dialysis, centrifugation (5000 rpm, 30 min) was carried out, followed by freeze-drying.
2. The oxidized glucomannan is prepared by the following method: weighing 1g of glucomannan (KGM) powder, placing the powder into 100ml of deionized water, and stirring and dissolving for 0.5 h; 1g of sodium periodate (NaIO) is weighed4) Adding the mixture into the obtained 1% KGM solution, and stirring the mixture for reaction for 12 hours at room temperature in a dark place; dialyzing the obtained product in a dialysis bag for 48h by pure water; centrifuging the obtained product, and freeze-drying to obtain the oxidized glucomannan.
3. Weighing 150mg of hydroxybutyl chitosan, dissolving the hydroxybutyl chitosan in 3.75mL of aqueous solution at 4 ℃ to form a solution with the concentration of 4wt%, weighing 10mg of oxidized glucomannan, dissolving the oxidized glucomannan in 0.5mL of aqueous solution with the final concentration of 2wt%, weighing 24mg of dopamine hydrochloride, dissolving the dopamine hydrochloride in 8.0mL of Tris-HCl buffer solution (10mM, pH8.5) with the final concentration of 3mg/mL, and fully and uniformly mixing the hydroxybutyl chitosan solution and the oxidized glucomannan solution to form the composite hydrogel. Coating 200 μ l dopamine solution on the surface of the composite hydrogel, and acting for 30 min.
Example 2: 1. the preparation of HBC is made by the prior art (refer to patent cn201110214776. x), and the procedure is as follows:
weighing 2g of chitosan powder, dispersing the chitosan powder in 50 mL of 50 wt% NaOH solution for alkalization, stirring the mixture for 24 hours at room temperature, and extruding redundant alkali liquor to obtain a solid matter; adding the obtained solid into 40 mL of 75 wt% isopropanol aqueous solution, and stirring for 24h until the alkalized chitosan is completely dispersed in an isopropanol-water system; measuring 40 mL of 1, 2-epoxybutane, dropwise adding into a reaction container, and reacting for 24 hours at 55 ℃; after the reaction is finished, cooling the reaction liquid to room temperature, and dropwise adding an HCl solution into the reaction liquid to adjust the pH value of the system to be neutral; dialyzing the obtained product in a dialysis bag, and dialyzing with running water for 3 days by pure water for 3 days; after dialysis, centrifugation (5000 rpm, 30 min) was carried out, followed by freeze-drying.
2. The oxidized glucomannan is prepared by the following method: weighing 2g of glucomannan (KGM) powder, placing the powder into 200ml of deionized water, and stirring and dissolving for 0.5 h; 2g of sodium periodate (NaIO) are weighed out4) Adding the mixture into the obtained 1% KGM solution, and stirring the mixture for reaction for 12 hours at room temperature in a dark place; dialyzing the obtained product in a dialysis bag for 48h by pure water; centrifuging the obtained product, and freeze-drying to obtain the oxidized glucomannan.
3. 150mg of hydroxybutyl chitosan is weighed and dissolved in 3mL of aqueous solution, the dissolution concentration at 4 ℃ is 5wt%, 10mg of oxidized glucomannan is weighed and dissolved in 0.5mL of aqueous solution, the dissolution final concentration at 65 ℃ is 2wt%, 16mg of dopamine hydrochloride is weighed and dissolved in 8.0mL of Tris-HCl buffer solution (10mM, pH8.5), the final concentration is 2mg/mL, and the hydroxybutyl chitosan solution and the oxidized glucomannan solution are fully and uniformly mixed to form the composite hydrogel. Coating 200 μ l dopamine solution on the surface of the composite hydrogel, and acting for 60 min.
Example 3: 1. the preparation of HBC is made by the prior art (refer to patent cn201110214776. x), and the procedure is as follows:
weighing 1g of chitosan powder, dispersing the chitosan powder in 50 mL of 50 wt% NaOH solution for alkalization, stirring the mixture for 24 hours at room temperature, and extruding redundant alkali liquor to obtain a solid matter; adding the obtained solid into 20 mL of 75 wt% isopropanol aqueous solution, and stirring for 24h until the alkalized chitosan is completely dispersed in an isopropanol-water system; measuring 20 mL of 1, 2-epoxybutane, dropwise adding into a reaction container, and reacting for 24h at 55 ℃; after the reaction is finished, cooling the reaction liquid to room temperature, and dropwise adding an HCl solution into the reaction liquid to adjust the pH value of the system to be neutral; dialyzing the obtained product in a dialysis bag, and dialyzing with running water for 3 days by pure water for 3 days; after dialysis, centrifugation (5000 rpm, 30 min) was carried out, followed by freeze-drying.
2. The oxidized glucomannan is prepared by the following method: weighing 1g of glucomannan (KGM) powder, placing the powder into 100ml of deionized water, and stirring and dissolving for 0.5 h; 1g of sodium periodate (NaIO) is weighed4) Adding the mixture into the obtained 1% KGM solution, and stirring the mixture for reaction for 12 hours at room temperature in a dark place; dialyzing the obtained product in a dialysis bag for 48h by pure water; centrifuging the obtained product, and freeze-drying to obtain the oxidized glucomannan.
3. Weighing 200mg of hydroxybutyl chitosan, dissolving the hydroxybutyl chitosan in 4mL of aqueous solution at 4 ℃ until the final concentration is 5wt%, weighing 15mg of oxidized glucomannan, dissolving the oxidized glucomannan in 0.375mL of aqueous solution at 65 ℃ until the final concentration is 4wt%, weighing 32mg of dopamine hydrochloride, dissolving the dopamine hydrochloride in 8.0mL of Tris-HCl buffer solution (10mM, pH8.5) until the final concentration is 4mg/mL, and fully and uniformly mixing the hydroxybutyl chitosan solution and the oxidized glucomannan solution to form the composite hydrogel. Coating 200 μ l dopamine solution on the surface of the composite hydrogel, and acting for 120 min.
Claims (3)
1. A preparation method of composite hydrogel with self-healing property and adhesion property comprises the following steps:
(1) preparation of hydroxybutyl chitosan according to patent (patent No. zl201110214776.x)
(2) Preparation of oxidized glucomannan: weighing glucomannan (KGM), dissolving in deionized water to obtain KGM solution, adding sodium periodate, stirring overnight, dialyzing, and freeze drying to obtain oxidized glucomannan (OKGM)
(3) Dissolving hydroxybutyl chitosan (HBC) and oxidized glucomannan (OKGM) in deionized water, and mixing the hydroxybutyl chitosan (HBC) solution and the oxidized glucomannan (OKGM) solution to obtain hydrogel
(4) Dissolving dopamine hydrochloride into Tris-HCl buffer solution (10mM, pH8.5), adding the obtained dopamine solution to the surface of the hydrogel to form a polydopamine coating, and finally forming the composite hydrogel.
2. The method according to claim 1, wherein the method comprises the steps of: the relative molecular mass of CS is 500-2000 kDa; the substitution degree of HBC is 90-160%; the molecular weight range of KGM is 200-2000 kDa; the oxidation degree of OKGM is 40-80%; the purity of OKGM is more than or equal to 98 percent; the mass ratio of HBC to OKGM in the reaction process is 1-20: 1; the coating time of the polydopamine is 10-180 min.
3. The method for preparing the composite hydrogel with both self-healing property and adhesiveness according to claim 1, wherein the method comprises the following steps: the concentration (w/v) of the oxidized glucomannan dissolved in the deionized water is 0.5-6 wt%; the concentration (w/v) of HBC dissolved in deionized water at low temperature is 3-5 wt%; the final concentration (w/v) of dopamine in Tris-HCl buffer (10mM, pH8.5) is 0.05-1 wt%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911245875.7A CN111269437A (en) | 2019-12-07 | 2019-12-07 | Preparation method of composite hydrogel with self-healing property and adhesion property |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911245875.7A CN111269437A (en) | 2019-12-07 | 2019-12-07 | Preparation method of composite hydrogel with self-healing property and adhesion property |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111269437A true CN111269437A (en) | 2020-06-12 |
Family
ID=70994689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911245875.7A Pending CN111269437A (en) | 2019-12-07 | 2019-12-07 | Preparation method of composite hydrogel with self-healing property and adhesion property |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111269437A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112706477A (en) * | 2020-12-28 | 2021-04-27 | 河南亚都实业有限公司 | Dandelion wool-based antibacterial hemostatic dressing |
| CN114081568A (en) * | 2021-11-19 | 2022-02-25 | 心凯诺医疗科技(上海)有限公司 | Embolic material and conveying system thereof |
| CN115069223A (en) * | 2022-06-30 | 2022-09-20 | 陕西科技大学 | Chitosan ion imprinted gel for adsorbing Cd (II), and preparation method and application thereof |
| CN115536919A (en) * | 2022-08-26 | 2022-12-30 | 武汉理工大学 | Modified chitosan adhesive hydrogel and preparation method and application thereof |
| CN115536920A (en) * | 2022-08-26 | 2022-12-30 | 武汉理工大学 | Chitosan derivative-based wound repair hydrogel and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105107008A (en) * | 2015-09-16 | 2015-12-02 | 中南民族大学 | Hydroxybutyl chitosan/oxidized sodium alginate/nano-silver composite hydrogel dressing plaster |
| WO2018045905A1 (en) * | 2016-09-07 | 2018-03-15 | 江南大学 | Catechol modified biological macromolecular scaffold material and preparation method therefor |
| CN109293948A (en) * | 2018-08-10 | 2019-02-01 | 广东省医疗器械研究所 | A kind of hydrogel and its preparation method and application |
| CN110437471A (en) * | 2019-07-11 | 2019-11-12 | 郑州轻工业学院 | A kind of viscosity composite hydrogel and its preparation method and application |
-
2019
- 2019-12-07 CN CN201911245875.7A patent/CN111269437A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105107008A (en) * | 2015-09-16 | 2015-12-02 | 中南民族大学 | Hydroxybutyl chitosan/oxidized sodium alginate/nano-silver composite hydrogel dressing plaster |
| WO2018045905A1 (en) * | 2016-09-07 | 2018-03-15 | 江南大学 | Catechol modified biological macromolecular scaffold material and preparation method therefor |
| CN109293948A (en) * | 2018-08-10 | 2019-02-01 | 广东省医疗器械研究所 | A kind of hydrogel and its preparation method and application |
| CN110437471A (en) * | 2019-07-11 | 2019-11-12 | 郑州轻工业学院 | A kind of viscosity composite hydrogel and its preparation method and application |
Non-Patent Citations (2)
| Title |
|---|
| CHEN, HONGLEI ET AL.: "An injectable self-healing hydrogel with adhesive and antibacterial properties effectively promotes wound healing", 《CARBOHYDRATE POLYMERS》 * |
| XIN ZHANG ET AL.: "The temperature-responsive hydroxybutyl chitosan hydrogels with polydopamine coating for cell sheet transplantation", 《INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES》 * |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112706477A (en) * | 2020-12-28 | 2021-04-27 | 河南亚都实业有限公司 | Dandelion wool-based antibacterial hemostatic dressing |
| CN114081568A (en) * | 2021-11-19 | 2022-02-25 | 心凯诺医疗科技(上海)有限公司 | Embolic material and conveying system thereof |
| CN114081568B (en) * | 2021-11-19 | 2022-08-30 | 心凯诺医疗科技(上海)有限公司 | Assembly comprising embolic material and delivery system therefor |
| CN115069223A (en) * | 2022-06-30 | 2022-09-20 | 陕西科技大学 | Chitosan ion imprinted gel for adsorbing Cd (II), and preparation method and application thereof |
| CN115069223B (en) * | 2022-06-30 | 2023-10-27 | 陕西科技大学 | Chitosan ion imprinting gel for adsorbing Cd (II) as well as preparation method and application thereof |
| CN115536919A (en) * | 2022-08-26 | 2022-12-30 | 武汉理工大学 | Modified chitosan adhesive hydrogel and preparation method and application thereof |
| CN115536920A (en) * | 2022-08-26 | 2022-12-30 | 武汉理工大学 | Chitosan derivative-based wound repair hydrogel and preparation method and application thereof |
| CN115536920B (en) * | 2022-08-26 | 2023-05-26 | 武汉理工大学 | Chitosan derivative-based wound repair hydrogel and preparation method and application thereof |
| CN115536919B (en) * | 2022-08-26 | 2024-01-19 | 武汉理工大学 | Modified chitosan adhesive hydrogel and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111269437A (en) | Preparation method of composite hydrogel with self-healing property and adhesion property | |
| Meng et al. | Mechanical, hydrophobic and thermal properties of an organic-inorganic hybrid carrageenan-polyvinyl alcohol composite film | |
| CN106478825B (en) | Method for preparing oxidized cellulose for hemostasis in ramie oxidation degumming process | |
| KR101428145B1 (en) | Water-insoluble gel composition and manufacturing method of the same | |
| CN112250889A (en) | Preparation method of double-network self-healing hydrogel containing Schiff base bonds and borate bonds | |
| CN109796606B (en) | Self-healing hydrogel based on multiple dynamic chemical bonds and preparation method thereof | |
| JP2002536465A (en) | Method for crosslinking hyaluronic acid to polymer | |
| CN112442207B (en) | Method for modifying polydimethylsiloxane material | |
| Guo et al. | Biofunctional chitosan–biopolymer composites for biomedical applications | |
| CN110746616A (en) | Cellulose hydrogel containing phenylboronic acid and preparation method and application thereof | |
| CN112661988B (en) | Preparation method of sodium alginate interpenetrating network hydrogel without ionic crosslinking | |
| CN111978568B (en) | Preparation method of catechol modified chitosan-alginate double-network hydrogel | |
| Vilela et al. | Development and applications of cellulose nanofibres based polymer nanocomposites | |
| Matsumura et al. | Oxidized polysaccharides as green and sustainable biomaterials | |
| JP4356289B2 (en) | Polysaccharide complex and method for producing the same | |
| Lopéz-Martínez et al. | Hydrogels for biomedicine based on semi-interpenetrating polymeric networks of collagen/guar gum: synthesis and physicochemical characterization | |
| Rossi et al. | Characterization of aerogels from chemo-enzymatically oxidized galactomannans as novel polymeric biomaterials | |
| CN110180023B (en) | Preparation method of high-strength biomass tissue engineering scaffold material | |
| CN111484634A (en) | Self-healing multi-bridged network chitosan-derived hydrogel and preparation method thereof | |
| Nguyen et al. | Synthesis of cross-linking chitosan-hyaluronic acid based hydrogels for tissue engineering applications | |
| JP4470410B2 (en) | Polysaccharide complex | |
| CN110229357B (en) | Preparation method of cross-linked hyaluronic acid gel | |
| Arshad et al. | Miscibility, properties, and biodegradability of chitin and chitosan | |
| CN116731365A (en) | High-strength, water-resistant and ultraviolet-resistant carboxymethyl cellulose/sodium alginate composite film and preparation method thereof | |
| CN110483810A (en) | A kind of preparation method of nano-cellulose anti-bacterial hydrogel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20200612 |
|
| WD01 | Invention patent application deemed withdrawn after publication |