CN111249555A

CN111249555A - Reverse simple ultrafiltration dialysis device in vivo

Info

Publication number: CN111249555A
Application number: CN202010119296.4A
Authority: CN
Inventors: 梁聪; 薛丽娜; 刘金凤; 牛红艳; 祝喜鹰
Original assignee: First Peoples Hospital of Changzhou
Current assignee: First Peoples Hospital of Changzhou
Priority date: 2020-02-26
Filing date: 2020-02-26
Publication date: 2020-06-09

Abstract

The invention relates to the technical field of medical instruments, in particular to an in-vivo reverse pure ultrafiltration dialysis device, which comprises an ultrafiltration dialysis unit, a negative pressure generation unit and a waste liquid drainage unit, wherein the negative pressure generation unit is communicated with the ultrafiltration dialysis unit, the waste liquid drainage unit is communicated with the ultrafiltration dialysis unit, and the ultrafiltration dialysis unit comprises a base, a sealing plate and an ultrafiltration dialysis beam. The invention can be embedded into the central vein of a patient for a long time, brings convenience to the patient, especially for the patient needing long-term hemodialysis, brings possibility for the dialysis patient to walk during dialysis, and particularly, can effectively reduce the treatment cost of the dialysis patient and the puncture times of the dialysis patient to reduce pain, can ensure that the patient can successfully dialyze, has no requirement on the specification of the liquid collecting bag, can use the liquid collecting bags of different specifications, and further has better practicability.

Description

Reverse simple ultrafiltration dialysis device in vivo

Technical Field

The invention relates to the technical field of medical instruments, in particular to an in-vivo reverse simple ultrafiltration dialysis device.

Background

Hemodialysis, also known as artificial kidney or kidney washing in popular parlance, is called hemodialysis for short, and is one of the blood purification techniques. The blood purification device utilizes the principle of a semipermeable membrane, and achieves the purposes of purifying blood and correcting water electrolyte and acid-base balance by dispersing and removing various harmful and redundant metabolic wastes and excessive electrolytes in the body. The semipermeable membrane used for hemodialysis has a thickness of 10-20 microns, and the average pore diameter on the membrane is 3 nanometers, so that only small molecules with molecular weight of less than 1.5 ten thousand and partial medium molecular substances are allowed to pass through, but macromolecular substances with molecular weight of more than 3.5 ten thousand cannot pass through. Thus, proteins, pyrogens, viruses, bacteria, blood cells, etc. are all impermeable; most of urine components are water, and a large amount of water must be removed from blood to replace kidneys with artificial kidneys, which can remove excessive water only by osmotic pressure and ultrafiltration pressure. The hemodialysis apparatus, which is an artificial kidney, has these functions, and regulates the quality and quantity of blood to approximate a physiological state.

In the existing dialysis device, blood is in a membrane during hemodialysis, filtrate is outside the membrane, that is, blood of a patient needs to be pumped out of the membrane for filtration, however, the mode has the following disadvantages, particularly for the patient needing long-term hemodialysis, inconvenience is brought to the patient, the patient needs to stay on a bed all the time during the dialysis, the dialysis patient can completely go on walking during the dialysis, and particularly, the treatment cost of the dialysis patient is greatly increased, and the puncture times of the dialysis patient are greatly increased, so that the pain is increased.

Therefore, an in vivo reverse simple ultrafiltration dialysis device is provided.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide an in-vivo reverse pure ultrafiltration dialysis device, blood is outside a membrane during hemodialysis, filtrate is inside the membrane, and the blood of a patient can be filtered without being pumped out of the body, so that the device can be embedded into the central vein of the patient for a long time, and particularly, the device can bring convenience to the patient needing hemodialysis for a long time, and bring possibility for the dialysis patient to walk during dialysis, and more importantly, the device can effectively reduce the treatment cost of the dialysis patient and the puncture times of the dialysis patient to reduce pain, so as to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

the utility model provides an internal reverse simple ultrafiltration dialysis device, includes ultrafiltration dialysis unit, negative pressure generating element and waste liquid drainage unit, negative pressure generating element with ultrafiltration dialysis unit communicates with each other and sets up, waste liquid drainage unit with ultrafiltration dialysis unit communicates with each other and sets up.

Through adopting above-mentioned technical scheme, the ultrafiltration dialysis unit that sets up is used for inserting the inside of patient central vein, the negative pressure generating unit that sets up is used for taking out the inside air of ultrafiltration dialysis unit so that the inside negative pressure that produces of ultrafiltration dialysis unit, utilize inside and the inside pressure differential of patient central vein of ultrafiltration dialysis unit, so that the inside of ultrafiltration dialysis unit is pressed to by the reversal filter to toxin moisture in the patient's blood, waste liquid drainage unit is used for flowing out and collecting the toxin moisture in the inside blood of ultrafiltration dialysis unit with the reversal filter pressing.

Further, the ultrafiltration dialysis unit includes that base, closing plate and ultrafiltration dialysis are restrainted, the inside of base is hollow structure, the fixed first connecting pipe that is linked together rather than inside that is equipped with in one side of base, just the fixed second connecting pipe that is linked together rather than inside that is equipped with of opposite side of base, the closing plate is fixed and install sealedly on the roof of base, ultrafiltration dialysis is restrainted fixed mounting and is in on the diapire of base, just ultrafiltration dialysis is restrainted with the inside of base is linked together.

Through adopting above-mentioned technical scheme, the base is used as ultrafiltration dialysis unit's major structure, and the closing plate is used for sealing up the base, and first connecting pipe is used for connecting negative pressure generating element, and the second connecting pipe is used for connecting waste liquid drainage unit, and ultrafiltration dialysis is restrainted and is used for inserting patient central venous inside, thereby utilizes pressure differential to realize the purpose of dialysis by reverse filter pressing to the inside of ultrafiltration dialysis to the toxin moisture in patient's blood.

Further, the base dorsad one side of first connecting pipe still fixedly is equipped with the third connecting pipe rather than inside being linked together, the third connecting pipe is kept away from the one end tip of base still the spiro union have the heparin cap, still fixed mounting has first check valve on the third connecting pipe, the direction of switching on of first check valve dorsad the setting of heparin cap.

Through adopting above-mentioned technical scheme, the third connecting pipe is used for connecting the heparin cap, and the heparin cap is used for connecting the syringe and utilizes normal saline to wash the inside of ultrafiltration dialysis bundle and base in order to prevent that the inside of ultrafiltration dialysis bundle and base is blockked up.

Furthermore, the peripheral edge of base still an organic whole is equipped with two fixing bases, two the fixing base is about first connecting pipe symmetry sets up.

Through adopting above-mentioned technical scheme, the setting up of two fixing bases makes the base be convenient for cooperate medical bandage or from the sticky tape to fix on patient's skin.

Further, the outside of ultrafiltration dialysis bundle still is equipped with ties up the mechanism, it includes first connecting seat, second connecting seat and cellosilk to tie up the mechanism, the fixed suit of first connecting seat is in the outside of ultrafiltration dialysis bundle, just a terminal surface of first connecting seat with the diapire fixed connection of base, the fixed suit of second connecting seat is in ultrafiltration dialysis bundle is kept away from the one end tip of base, just the second connecting seat dorsad embedded filter screen of installing on the terminal surface of first connecting seat, the cellosilk is the heliciform winding the outside of ultrafiltration dialysis bundle, the one end of cellosilk with first connecting seat fixed connection, just the other end of cellosilk with second connecting seat fixed connection.

Through adopting above-mentioned technical scheme, tie up the mechanism through setting up, and tie up the mechanism and comprise first connecting seat, second connecting seat and cellosilk, first connecting seat is the cylindrical structure, first connecting seat can be used for inserting the incision of ultrafiltration dialysis bundle and the incision on the central vein identical on patient's the skin like this, can avoid ultrafiltration dialysis bundle and patient's skin and the venous blood of the junction patient of central vein to take place the condition of seepage, the second connecting seat is used for connecting the cellosilk and is used for tying up ultrafiltration dialysis bundle simultaneously, the cellosilk is used for tying up ultrafiltration dialysis bundle, can avoid ultrafiltration dialysis bundle to be in disorder, the filter screen is used for protecting the one end tip that ultrafiltration dialysis bundle kept away from the base, can avoid the too big one end tip that leads to ultrafiltration dialysis bundle to keep away from the base of pressure to warp or break.

Furthermore, the ultrafiltration dialysis beam is composed of a plurality of semi-permeable membrane pipes, one ends of the semi-permeable membrane pipes are open ends, the other ends of the semi-permeable membrane pipes are closed ends, the open ends of the semi-permeable membrane pipes are fixedly mounted on the bottom wall of the base through assembling seats, the closed ends of the semi-permeable membrane pipes are semi-circular arc ends, and a plurality of support rings which are arranged equidistantly are embedded in the pipe walls of the semi-permeable membrane pipes.

Through adopting above-mentioned technical scheme, the ultrafiltration dialysis is restrainted and is become by a plurality of semipermeable membrane pipes to make the ultrafiltration dialysis to be restrainted and possess the nature of selective permeability, can guarantee that the ultrafiltration dialysis is restrainted and is filter-pressed the toxin moisture in patient's blood to inside in reverse, the support ring is used for supporting every semipermeable membrane pipe, can avoid semipermeable membrane pipe to flatten by blood pressure and lead to its unable work.

Further, the negative pressure generating unit comprises a box body, a box cover, a negative pressure pump, a gas pipe, a controller, a storage battery, a pressure sensor and a touch display screen, the rear part of the box body is of an open structure, the box cover is fixedly arranged at the rear part of the box body, a plurality of through holes are uniformly formed in the box cover, the negative pressure pump is fixedly arranged in the box body, the gas pipe is fixedly arranged on the bottom wall of the box body, one end of the gas pipe is fixedly and communicated with an air suction opening of the negative pressure pump, the other end of the gas pipe is fixedly and communicated with the first connecting pipe through a first connecting head, the first connecting head is in threaded connection with one end of the first connecting pipe far away from the base, the controller and the storage battery are fixedly arranged in the box body, and a control output end of the controller is electrically connected with an electric control end of the negative pressure pump, the storage battery is respectively and electrically connected with the controller and the negative pressure pump, the pressure sensor is embedded on the sealing plate, the sensing part of the pressure sensor is communicated with the inside of the base, the signal output end of the pressure sensor is electrically connected with the signal input end of the controller, the touch display screen is embedded in the front part of the box body and is electrically connected with the controller in a two-way mode.

By adopting the technical scheme, the pressure sensor is used for detecting the pressure data in the base and the ultrafiltration dialysis beam and uploading the pressure data to the controller in real time, the controller controls the working state of the negative pressure pump in real time according to the pressure data uploaded by the pressure sensor so as to ensure that the pressure in the base and the ultrafiltration dialysis beam is in a stable negative pressure state, the storage battery is used for supplying power to the negative pressure pump, the controller, the pressure sensor and the touch display screen, and the touch display screen is used for displaying the pressure data, the pressure sensor, the working state of the controller and the negative pressure pump in real time and modifying the working parameters of the pressure sensor, the controller and the negative pressure pump.

Further, still be equipped with switch on the lateral wall of box body and the interface that charges, switch with the interface that charges all with battery electric connection.

Through adopting above-mentioned technical scheme, switch is used for controlling the device switching on and shutting down, and the interface that charges is used for charging for the battery.

Further, still fixed mounting has correlation type photoelectric sensor on the interior diapire of box body, correlation type photoelectric sensor's transmitting terminal and receiving terminal distribute in tracheal both sides, just correlation type photoelectric sensor's signal output part with the signal input part electric connection of controller, still fixed mounting has the solenoid valve on the trachea, the solenoid valve is located correlation type photoelectric sensor with between the extraction opening of negative pressure pump, just the automatically controlled end of solenoid valve still with the control output electric connection of controller.

Through adopting above-mentioned technical scheme, correlation type photoelectric sensor is used for real-time detection whether tracheal inside gets into liquid, when detecting tracheal inside entering liquid, transmits the controller on with detected signal, and controller control solenoid valve closes, can avoid negative pressure pump inside to damage because of getting into liquid.

Further, the waste liquid drainage unit comprises two second one-way valves, a flowmeter, a drainage tube, a liquid collecting bag and a horn, wherein the two second one-way valves are fixedly arranged on the second connecting tube, the conduction directions of the two second one-way valves are back to the base, the flowmeter is fixedly arranged on the second connecting tube and is positioned between the two second one-way valves, the signal output end of the flowmeter is also electrically connected with the signal input end of the controller, one end of the drainage tube is fixedly and communicated with the second connecting tube through a second connector, the second connector is in threaded connection with one end of the second connecting tube back to the base, the other end of the drainage tube is fixedly and communicated with one end of the liquid collecting bag, and the horn is fixedly arranged in the box body, and the electric control end of the loudspeaker is electrically connected with the control output end of the controller.

Through adopting above-mentioned technical scheme, under the effect of two second check valves, the second connecting pipe can only be used for the outside waste liquid that flows out, can prevent that the inside liquid of collection liquid bag from flowing backward into the inside of base, simultaneously under the effect of two second check valves, the liquid volume of the inside flowmeter of flowing through of second connecting pipe is more stable, can avoid the many data of flowmeter, thereby guarantee that the data of flowmeter statistics are more accurate, and then guarantee when liquid bag is full of the waste liquid in inside collection, the controller can in time control loudspeaker and report to the police and remind medical personnel in time to change collection liquid bag, in order to guarantee that patient dialyses smoothly, also make the device not have the requirement to the specification of collection liquid bag simultaneously, can use the collection liquid bag of different specifications, as long as set up the statistical parameter of flowmeter through the touch-control display screen can, and then make the device practicality better.

In summary, the invention mainly has the following beneficial effects:

1. the invention is provided with an ultrafiltration dialysis unit which is inserted into the central vein of a patient, a negative pressure generating unit which is used for pumping out air in the ultrafiltration dialysis unit to generate negative pressure in the ultrafiltration dialysis unit, and the negative pressure generating unit is used for utilizing the pressure difference between the interior of the ultrafiltration dialysis unit and the interior of the central vein of the patient to enable toxin moisture in the blood of the patient to be reversely filter-pressed into the interior of the ultrafiltration dialysis unit, meanwhile, the ultrafiltration dialysis unit is composed of a base, a sealing plate and an ultrafiltration dialysis beam, and the ultrafiltration dialysis beam is composed of a plurality of semi-permeable membrane pipes, so that the ultrafiltration dialysis beam can be embedded into the interior of the central vein of the patient for a long time, and further, blood is outside the membrane when the device is permeated, filtrate is inside the membrane, and the blood of the patient can be filtered without pumping the blood of the patient to the outside, especially for the patient needing long-term hemodialysis, the patient can still walk during dialysis, and more importantly, the treatment cost of the dialysis patient can be effectively reduced, and the puncture times of the dialysis patient can be effectively reduced to reduce pain;

2. according to the invention, the waste liquid drainage unit comprises the two second one-way valves, the flowmeter, the drainage tube, the liquid collection bag and the loudspeaker, under the action of the two second one-way valves, the statistical data of the flowmeter can be accurate, meanwhile, the signal output end of the flowmeter is electrically connected with the signal input end of the controller, and the electric control end of the loudspeaker is electrically connected with the control output end of the controller, so that when the flow data counted by the flowmeter reaches a set value, the controller controls the loudspeaker to give an alarm to remind medical workers to replace the liquid collection bag in time, so that patients can be dialyzed smoothly, meanwhile, the device has no requirement on the specification of the liquid collection bag, the liquid collection bags with different specifications can be used, and the device has better practicability.

Drawings

FIG. 1 is a schematic view of an in vivo reverse simple ultrafiltration dialysis device according to an embodiment;

FIG. 2 is a schematic structural diagram of another perspective of an in vivo reverse simple ultrafiltration dialysis device according to an embodiment;

FIG. 3 is a second schematic view of an in vivo reverse simple ultrafiltration dialysis device according to an embodiment;

FIG. 4 is an enlarged schematic view of a portion A of FIG. 3;

FIG. 5 is an enlarged schematic view of a portion B of FIG. 3;

FIG. 6 is a schematic diagram of the structure of an ultrafiltration dialysis unit of an in vivo reverse simple ultrafiltration dialysis apparatus according to an embodiment;

FIG. 7 is a schematic cross-sectional view of an ultrafiltration dialysis unit of an in vivo reverse simple ultrafiltration dialysis device according to an embodiment;

FIG. 8 is an enlarged schematic view of the detail view C of FIG. 7;

FIG. 9 is a schematic structural view of a semipermeable membrane tube of an ultrafiltration dialysis beam of an ultrafiltration dialysis unit of the in vivo reverse simple ultrafiltration dialysis apparatus according to one embodiment;

FIG. 10 is a schematic cross-sectional view of a semipermeable membrane tube of an ultrafiltration dialysis beam of an ultrafiltration dialysis unit of the in vivo reverse simple ultrafiltration dialysis apparatus according to one embodiment;

FIG. 11 is an enlarged schematic view of detail D of FIG. 10;

FIG. 12 is a schematic view of a negative pressure generating unit of the in vivo reverse simple ultrafiltration dialysis apparatus according to an embodiment;

FIG. 13 is a schematic diagram of an exploded structure of a negative pressure generating unit of the in vivo reverse simple ultrafiltration dialysis device according to an embodiment;

fig. 14 is an enlarged schematic view of a partial view E of fig. 13.

In the figure: 1. an ultrafiltration dialysis unit; 2. a negative pressure generating unit; 3. a waste liquid drainage unit; 4. a base; 5. a sealing plate; 6. a pressure sensor; 7. a first connecting pipe; 8. a third connecting pipe; 9. a second connecting pipe; 10. ultrafiltering the dialysis beam; 11. a strapping mechanism; 12. a first connecting seat; 13. fiber yarn; 14. a second connecting seat; 15. a filter screen; 16. a fixed seat; 17. assembling a base; 18. a semi-permeable membrane tube; 19. a support ring; 20. a first connector; 21. an air tube; 22. a first check valve; 23. a heparin cap; 24. a second one-way valve; 25. a flow meter; 26. a second connector; 27. a drainage tube; 28. a liquid collecting bag; 29. a box body; 30. a touch display screen; 31. a box cover; 32. a power switch; 33. a charging interface; 34. a storage battery; 35. a controller; 36. a horn; 37. a negative pressure pump; 38. a through hole; 39. a correlation type photoelectric sensor; 40. an electromagnetic valve.

Detailed Description

In order to facilitate the examination of the technical features, contents, advantages and effects achieved by the present invention, the present invention will be described in detail with reference to the accompanying drawings and embodiments, wherein the drawings are used for illustration and assistance of the specification, and are not necessarily the actual proportion and precise configuration after the implementation of the present invention, and therefore, the present invention should not be read and limited by the proportion and the configuration relationship of the drawings, and the following detailed description will be made with reference to fig. 1 to 14.

Example 1

The utility model provides an internal reverse simple ultrafiltration dialysis device, as shown in fig. 1-3, includes ultrafiltration dialysis unit 1, negative pressure generating unit 2 and waste liquid drainage unit 3, negative pressure generating unit 2 with ultrafiltration dialysis unit 1 communicates with each other and sets up, waste liquid drainage unit 3 with ultrafiltration dialysis unit 1 communicates with each other and sets up.

Through adopting above-mentioned technical scheme, the inside of ultrafiltration dialysis unit 1 that sets up is used for inserting patient central vein, the negative pressure generating unit 2 that sets up is used for taking out the inside air of ultrafiltration dialysis unit 1 so that ultrafiltration dialysis unit 1 is inside to produce the negative pressure, utilize the inside and the inside pressure differential of patient central vein of ultrafiltration dialysis unit 1, so that the inside of ultrafiltration dialysis unit 1 is pressed to by the reverse filter to toxin moisture in the patient's blood, waste liquid drainage unit 3 is used for flowing out and collecting the toxin moisture that the inside blood of ultrafiltration dialysis unit 1 was pressed to the reverse filter.

Preferably, as shown in fig. 2 to 6, the ultrafiltration dialysis unit 1 includes a base 4, a sealing plate 5 and an ultrafiltration dialysis bundle 10, wherein the interior of the base 4 is a hollow structure, a first connection pipe 7 is fixedly disposed on one side of the base 4 and is communicated with the interior of the base 4, a second connection pipe 9 is fixedly disposed on the other side of the base 4 and is communicated with the interior of the base, the sealing plate 5 is fixedly and hermetically mounted on the top wall of the base 4, the ultrafiltration dialysis bundle 10 is fixedly mounted on the bottom wall of the base 4, and the ultrafiltration dialysis bundle 10 is communicated with the interior of the base 4.

Through adopting above-mentioned technical scheme, base 4 is used as ultrafiltration dialysis unit 1's major structure, and closing plate 5 is used for sealing base 4, and first connecting pipe 7 is used for connecting negative pressure generating element 2, and second connecting pipe 9 is used for connecting waste liquid drainage unit 3, and ultrafiltration dialysis is restrainted 10 and is used for inserting the inside of patient's central vein, thereby utilizes the pressure differential to realize the purpose of dialysis by reverse filter pressing the inside of ultrafiltration dialysis bundle 10 with the toxin moisture in patient's blood.

Preferably, as shown in fig. 5 and 6, a third connecting pipe 8 communicated with the inside of the base 4 is further fixedly disposed on a side of the base 4 facing away from the first connecting pipe 7, a heparin cap 23 is further screwed on an end portion of the third connecting pipe 8 far away from the base 4, a first one-way valve 22 is further fixedly mounted on the third connecting pipe 8, and a conduction direction of the first one-way valve 22 is set facing away from the heparin cap 23.

By adopting the above technical solution, the third connecting tube 8 is used for connecting the heparin cap 23, and the heparin cap 23 is used for connecting a syringe to flush the ultrafiltration dialysis beam 10 and the inside of the base 4 with the physiological saline so as to prevent the ultrafiltration dialysis beam 10 and the inside of the base 4 from being blocked.

Preferably, as shown in fig. 6, the peripheral edge of the base 4 is further integrally provided with two fixing seats 16, and the two fixing seats 16 are symmetrically arranged about the first connecting pipe 7.

Through adopting above-mentioned technical scheme, the setting of two fixing bases 16 makes base 4 be convenient for cooperate medical bandage or from the sticky tape to fix on patient's skin.

Preferably, as shown in fig. 2 and 6, a bundling mechanism 11 is further disposed outside the ultrafiltration dialysis bundle 10, the bundling mechanism 11 includes a first connecting seat 12, a second connecting seat 14 and a fiber filament 13, the first connecting seat 12 is fixedly sleeved outside the ultrafiltration dialysis bundle 10, an end surface of the first connecting seat 12 is fixedly connected to the bottom wall of the base 4, the second connecting seat 14 is fixedly sleeved on an end portion of the ultrafiltration dialysis bundle 10 far away from the base 4, a filter screen 15 is embedded on an end surface of the second connecting seat 14 facing away from the first connecting seat 12, the fiber filament 13 is spirally wound outside the ultrafiltration dialysis bundle 10, one end of the fiber filament 13 is fixedly connected to the first connecting seat 12, and the other end of the fiber filament 13 is fixedly connected to the second connecting seat 14.

By adopting the technical scheme, the bundling mechanism 11 is arranged, the bundling mechanism 11 is composed of the first connecting seat 12, the second connecting seat 14 and the fiber yarns 13, the first connecting seat 12 is in a cylindrical structure, such that the first connector 12 can be mated with an incision in the patient's skin for insertion of the ultrafiltration dialysis bundle 10 and an incision in the central vein, the condition that the venous blood of the patient leaks from the connection part of the ultrafiltration dialysis beam 10 and the skin and the central vein of the patient can be avoided, the second connecting base 14 is used for connecting the fiber 13 and simultaneously for tightening the ultrafiltration dialysis bundle 10, the fiber 13 is used for tightening the ultrafiltration dialysis bundle 10, the scattering of the ultrafiltration dialysis beam 10 can be avoided, the filter screen 15 is used for protecting the end part of the ultrafiltration dialysis beam 10 far away from the base 4, the end of the ultrafiltration dialysis beam 10 away from the base 4 that is deformed or broken due to excessive pressure can be avoided.

Preferably, as shown in fig. 6 to 11, the ultrafiltration dialysis beam 10 is composed of a plurality of semipermeable membrane tubes 18, one end of each of the semipermeable membrane tubes 18 is an open end, the other end of each of the semipermeable membrane tubes 18 is a closed end, the open ends of the semipermeable membrane tubes 18 are all fixedly mounted on the bottom wall of the base 4 through an assembling seat 17, the closed ends of the semipermeable membrane tubes 18 are all semicircular ends, and a plurality of support rings 19 arranged at equal intervals are embedded inside the tube walls of the semipermeable membrane tubes 18.

By adopting the technical scheme, the ultrafiltration dialysis bundle 10 is composed of the plurality of semi-permeable membrane tubes 18, so that the ultrafiltration dialysis bundle 10 has the property of selective permeability, the ultrafiltration dialysis bundle 10 can be ensured to reversely filter and press toxin moisture in the blood of a patient into the interior of the ultrafiltration dialysis bundle, the support ring 19 is used for supporting each semi-permeable membrane tube 18, and the semi-permeable membrane tubes 18 can be prevented from being crushed by blood pressure to cause the semi-permeable membrane tubes 18 to be incapable of working.

Preferably, as shown in fig. 4, 6 and 12-13, the negative pressure generating unit 2 includes a box body 29, a box cover 31, a negative pressure pump 37, an air tube 21, a controller 35, a storage battery 34, a pressure sensor 6 and a touch display screen 30, the rear portion of the box body 29 is an open structure, the box cover 31 is fixedly installed at the rear portion of the box body 29, a plurality of through holes 38 are uniformly formed in the box cover 31, the negative pressure pump 37 is fixedly installed inside the box body 29, the air tube 21 is fixedly installed on the bottom wall of the box body 29, one end of the air tube 21 is fixedly and communicatively connected with an air suction port of the negative pressure pump 37, the other end of the air tube 21 is fixedly and communicatively connected with the first connecting tube 7 through a first connector 20, the first connector 20 is in threaded connection with one end of the first connecting tube 7 far away from the base 4, the controller 35 and the storage battery 34 are both fixedly installed inside the box body 29, the control output of controller 35 with negative pressure pump 37's automatically controlled end electric connection, battery 34 respectively with controller 35 with negative pressure pump 37 electric connection, pressure sensor 6 inlays the dress and is in on the sealing plate 5, just pressure sensor 6's response portion with the inside of base 4 is linked together, pressure sensor 6's signal output part with controller 35's signal input part electric connection, the embedded installation of touch-control display screen 30 is in the front portion of box body 29, just touch-control display screen 30 with the two-way electric connection of controller 35.

By adopting the above technical scheme, the pressure sensor 6 is used for detecting the pressure data inside the base 4 and the ultrafiltration dialysis beam 10 and uploading the pressure data to the controller 35 in real time, the controller 35 controls the working state of the negative pressure pump 37 in real time according to the pressure data uploaded by the pressure sensor 6 to ensure that the pressure inside the base 4 and the ultrafiltration dialysis beam 10 is in a stable negative pressure state, the storage battery 34 is used for supplying power to the negative pressure pump 37, the controller 35, the pressure sensor 6 and the touch display screen 30, and the touch display screen 30 is used for displaying the pressure data, the working state of the pressure sensor 6, the controller 35 and the negative pressure pump 37 in real time and modifying the working parameters of the pressure sensor 6, the controller 35 and the negative pressure pump 37.

Preferably, as shown in fig. 12 to 13, a power switch 32 and a charging interface 33 are further disposed on one side wall of the box body 29, and both the power switch 32 and the charging interface 33 are electrically connected to the storage battery 34.

By adopting the technical scheme, the power switch 32 is used for controlling the device to be turned on and turned off, and the charging interface 33 is used for charging the storage battery 34.

Preferably, as shown in fig. 13 to 14, an opposite photoelectric sensor 39 is further fixedly mounted on the inner bottom wall of the box 29, the transmitting end and the receiving end of the opposite photoelectric sensor 39 are distributed on two sides of the air pipe 21, the signal output end of the opposite photoelectric sensor 39 is electrically connected to the signal input end of the controller 35, an electromagnetic valve 40 is further fixedly mounted on the air pipe 21, the electromagnetic valve 40 is located between the opposite photoelectric sensor 39 and the suction opening of the negative pressure pump 37, and the electric control end of the electromagnetic valve 40 is further electrically connected to the control output end of the controller 35.

Through adopting above-mentioned technical scheme, correlation type photoelectric sensor 39 is used for the inside entering liquid of real-time detection trachea 21, when detecting the inside entering liquid of trachea 21, transmits the detected signal to controller 35 on, and controller 35 control solenoid valve 40 closes, can avoid negative pressure pump 37 inside because of entering liquid and damaging.

Preferably, as shown in fig. 2-4, the waste liquid drainage unit 3 includes two second one-way valves 24, a flow meter 25, a drainage tube 27, a liquid collecting bag 28 and a speaker 36, wherein the two second one-way valves 24 are both fixedly mounted on the second connecting pipe 9, the conducting directions of the two second one-way valves 24 are both set back to the base 4, the flow meter 25 is fixedly mounted on the second connecting pipe 9, the flow meter 25 is located between the two second one-way valves 24, the signal output end of the flow meter 25 is further electrically connected with the signal input end of the controller 35, one end of the drainage tube 27 is fixedly and communicatively connected with the second connecting pipe 9 through a second connector 26, the second connector 26 is in threaded connection with one end of the second connecting pipe 9 back to the base 4, the other end of the drainage tube 27 is fixedly and communicatively connected with one end of the liquid collecting bag 28, the speaker 36 is fixedly mounted inside the box 29, and the electric control end of the speaker 36 is electrically connected to the control output end of the controller 35.

By adopting the above technical scheme, under the action of the two second one-way valves 24, the second connecting pipe 9 can only be used for flowing the waste liquid outwards, the liquid in the liquid collecting bag 28 can be prevented from flowing back to the inside of the base 4, at the same time, under the action of the two second check valves 24, the amount of liquid flowing through the flow meter 25 inside the second connecting pipe 9 is relatively stable, the data of the flowmeter 25 can be avoided from being measured more, thereby ensuring that the data counted by the flowmeter 25 is more accurate, further ensuring that when the liquid collection bag 28 is filled with waste liquid, the controller 35 can control the horn 36 to alarm and remind medical staff to replace the liquid collection bag 28 in time, so as to ensure that the patient can dialyze smoothly, meanwhile, the device has no requirement on the specification of the liquid collecting bag 28, the liquid collecting bags 28 with different specifications can be used, and only the statistical parameters of the flow meter 25 are set through the touch display screen 30, so that the device is good in practicability.

It should be noted that the overall shape of the ultrafiltration dialysis beam 10 is cylindrical, the diameter of the ultrafiltration dialysis beam 10 is not more than 4mm (determined based on the diameter of the central venous blood vessel of a human being which can reach 6 mm), the length is not more than 30cm, the ultrafiltration rate is 30-40ml/h.mmhg, and the semipermeable membrane tube 18 constituting the ultrafiltration dialysis beam 10 can be made of a semipermeable membrane with the model F60, the filtration rate of the semipermeable membrane with the model F60 is 40ml/h.mmhg, and if the ultrafiltration volume of a patient is 4800ml in 48 hours, then 100ml per hour of ultrafiltration is carried out, then the value of the negative pressure to be provided is 100 ml/40 ml/h.mmhg, which is 2.5mmHg, so that in order to ensure that the device can reach the filtration rate of 100ml/h, the negative pressure pump 37 must be controlled to work in real time to ensure that the negative pressure inside the ultrafiltration dialysis beam 10 is not less than 2.5mmHg, and the pressure sensor 6 is used to monitor the, the controller 35 adjusts the working state of the negative pressure pump 37 according to the data monitored by the pressure sensor 6, meanwhile, the flow meter 25 is used for monitoring the amount of the discharged waste liquid in real time, the controller 35 determines whether the amount of the discharged waste liquid is in a set range, when the amount of the discharged waste liquid is not in the set range, the controller 35 controls the negative pressure pump 37 to automatically adjust the pressure until the outflow speed of the waste liquid monitored by the flow meter 25 in real time is consistent with a target value, when the liquid collecting bag 28 is filled with the waste liquid, the controller 35 controls the loudspeaker 36 to give an alarm to remind medical staff of replacing the liquid collecting bag 28 in time, and the touch display screen 30 is used for displaying the pressure data in real time, the working states of the pressure sensor 6, the controller 35 and the negative pressure pump 37 and is used for modifying the working parameters of the pressure sensor 6, the controller 35 and the negative pressure;

secondly, still can be based on LPC 904's hourglass blood monitoring intelligent sensor at the internally mounted of base 4, and will be based on LPC904 leak blood monitoring intelligent sensor and controller 35 electric connection, can be used to the real-time supervision ultrafiltration dialysis and restraint 10 and whether take place the broken phenomenon of membrane, when the ultrafiltration dialysis is restrainted 10 and is taken place the broken phenomenon of membrane, patient's blood will get into the inside of ultrafiltration dialysis and restraint 10, not only influence the dialysis effect, still can lead to patient's blood loss, when the ultrafiltration dialysis is restrainted 10 and takes place the broken phenomenon of membrane, controller 35 control loudspeaker 36 reports to the police, and show alarm information at touch-control display screen 30, remind medical personnel in time to handle and change the device, and then guarantee patient's safety.

In addition, the controller 35 can select the singlechip that the model is STC89C51, pressure sensor 6 can select the pressure sensor that the model is U7100, negative pressure pump 37 can select the miniature negative pressure pump of VM series, correlation type photoelectric sensor 39 can select the photoelectric sensor that ohm dragon EE-SX1109 sees through the type, flowmeter 25 can select the miniature flowmeter that the model that combines fertile Smith flow meter limited production is Smith 5013.

Example 2

The difference from the embodiment 1 is that the outer surface of the box body 29 is further provided with a protective layer, and the protective layer is prepared by the following method:

weighing the following raw materials in parts by weight: 18-25 parts of epoxy resin, 8-12 parts of calcium carbonate powder, 10-12 parts of nano silver powder, 12-16 parts of phenolic resin, 8-10 parts of titanium dioxide powder, 2-4 parts of alcohol ester dodeca, 2-4 parts of triethanolamine, 1-3 parts of high-carbon alcohol fatty acid ester compound and 30-40 parts of water;

s1, adding the weighed alcohol ester dodeca, triethanolamine, higher alcohol fatty acid ester compound and water into a stirrer, and stirring for 20-30min at the stirring speed of 600-;

s2, adding epoxy resin, calcium carbonate powder, nano silver powder, phenolic resin and titanium dioxide powder into a grinder to grind until the particle diameter of the material is not more than 200nm, so as to prepare a mixed powder material;

s3, adding the mixed solution prepared in the step S1 and the mixed powder material prepared in the step S2 into a reaction kettle, stirring for 20-30min, setting the stirring speed of the reaction kettle to be 700-900r/min, setting the temperature to be 80-100 ℃, and filtering the mixed solution in the reaction kettle by using a 100-mesh filter screen when the temperature is reduced to 40-50 ℃ after the reaction kettle stops working, wherein the obtained filtrate is the prepared protective coating;

s4, dipping and wiping the outer surface of the box body 29 by using dust-free cloth, and then uniformly spraying the protective coating prepared in the step S3 on the outer surface of the box body 29 by using a high-pressure sprayer spray gun to form a coating film with the thickness of 200-;

s5, drying and curing the box body 29 sprayed with the protective coating in the step S4 in an oven, wherein the drying and curing temperature is 80-100 ℃, and the drying and curing time is 30-40min, so that the protective layer is manufactured on the outer surface of the box body 29.

The case 29 of example 1-2 was placed in a laboratory in a bacterial incubator with the same conditions for 120 hours, and then removed and observed under a microscope to have the following table:

examples	Observation results
		Example 1	The outer surface of the box body 29 nourishes a large amount of bacteria
Example 2	The outer surface of the box body 29 nourishes a smaller amount of bacteria

The comparative analysis of the results observed from the above table shows that the embodiment 2 is the optimal embodiment, by adopting the above technical scheme, the process for preparing the protective coating is simple in steps and easy to implement, the prepared protective coating has moderate viscosity, is not easy to delaminate, is convenient to spray, does not generate bubbles, is fully combined with various components, and has good comprehensive performance, so that the protective coating can form a good coating after spraying, is not easy to generate cracks, and has a good film forming effect, the prepared protective layer has good corrosion resistance, antibacterial performance and anti-aging performance, has good adhesiveness and is not easy to fall off, and the corrosion resistance, antibacterial performance and anti-aging performance of the box body 29 can be effectively improved, so that the device has a long service life, and particularly, the protective coating can prevent the box body 29 from nourishing a large amount of bacteria on the outer surface in the long-term use process.

The working principle is as follows: the internal reverse simple ultrafiltration dialysis device comprises an ultrafiltration dialysis unit 1 which is arranged to be inserted into the central vein of a patient, a negative pressure generating unit 2 which is arranged to pump out air inside the ultrafiltration dialysis unit 1 to generate negative pressure inside the ultrafiltration dialysis unit 1, and a plurality of semipermeable membrane tubes 18 which are arranged to form an ultrafiltration dialysis bundle 10 by utilizing the pressure difference between the inside of the ultrafiltration dialysis unit 1 and the inside of the central vein of the patient, so that toxin moisture in the blood of the patient is reversely filter-pressed into the ultrafiltration dialysis unit 1, and the ultrafiltration dialysis unit 1 comprises a base 4, a sealing plate 5 and the ultrafiltration dialysis bundle 10, and the ultrafiltration dialysis bundle 10 is formed by the semipermeable membrane tubes 18, so that the ultrafiltration dialysis bundle 10 can be embedded into the central vein of the patient for a long time, and further blood is outside the membrane when the device is permeated, and filtrate is in the membrane, and the blood of the patient can be filtered without being pumped out of the body, especially for the patient, the device provided by the invention can bring convenience to the dialysis machine, and brings possibility for the dialysis patient to walk during dialysis, especially importantly, the treatment cost of the dialysis patient can be effectively reduced, the puncture frequency of the dialysis patient can be effectively reduced, so that the pain is reduced, and in addition, the frequency of going to a hospital can be reduced for the dialysis patient;

the waste liquid drainage unit 3 that sets up is by two second check valves 24, flowmeter 25, drainage tube 27, collect liquid bag 28 and loudspeaker 36, can make flowmeter 25's statistical data more accurate under two second check valves 24's effect, simultaneously flowmeter 25 signal output part and controller 35's signal input part electric connection, loudspeaker 36's automatically controlled end and controller 35's control output electric connection, when the flow data of flowmeter 25 statistics reaches the setting value like this, controller 35 control loudspeaker 36 reports to the police and reminds medical personnel in time to change collect liquid bag 28, in order to guarantee that patient dialyses smoothly, also make the device not have the requirement to the specification of collecting liquid bag 28 simultaneously, can use the collecting liquid bag 28 of different specifications, and then make the device practicality better.

The using method comprises the following steps: when in use, the skin at the central vein of a patient is cut, then the central vein of the patient is cut by a medical means, the ultrafiltration dialysis bundle 10 is embedded into the central vein of the patient, then suture treatment is carried out, the device is started up through the power switch 32, then the controller 35 controls the negative pressure pump 37 to work, air in the ultrafiltration dialysis bundle 10 and the base 4 is pumped out to enable negative pressure to be generated in the ultrafiltration dialysis bundle 10, toxin moisture in the blood of the patient is reversely filtered and pressed into the ultrafiltration dialysis unit 1, meanwhile, the negative pressure generating unit 2 is placed above the base 4, the waste liquid drainage unit 3 of the waste liquid drainage unit 3 is placed below the base 4, filtrate in the ultrafiltration dialysis unit 1 enters the liquid collection bag 28 along the drainage tube 27, when the liquid flow counted by the flow meter 25 reaches set data, the controller 35 can timely control the horn 36 to alarm and remind medical personnel to replace the liquid collection bag 28 in time, when changing a liquid bag 28, with drainage tube 27 clamp closed, removable liquid bag 28 that collects, perhaps install the valve additional on second connecting pipe 9, be convenient for like this change a liquid bag 28, when base 4 or ultrafiltration dialysis bundle 10 are inside to be blockked up, accessible heparin cap 23 is connected the syringe and is utilized normal saline to wash the inside of ultrafiltration dialysis bundle 10 and base 4, what need notice simultaneously is that the regular monitoring imbeds the thrombus formation condition of internal part, need move softly when drawing the pipe, avoid the thrombus to drop, draw the pipe after the partial fuse of going forward of drawing the pipe if necessary.

The parts not involved in the present invention are the same as or can be implemented by the prior art. The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.

Claims

1. An in vivo reverse simple ultrafiltration dialysis device, which is characterized in that: including ultrafiltration dialysis unit (1), negative pressure generating unit (2) and waste liquid drainage unit (3), negative pressure generating unit (2) with ultrafiltration dialysis unit (1) communicates with each other and sets up, waste liquid drainage unit (3) with ultrafiltration dialysis unit (1) communicates with each other and sets up.

2. The in vivo reverse simple ultrafiltration dialysis device of claim 1, wherein: ultrafiltration dialysis unit (1) includes base (4), closing plate (5) and ultrafiltration dialysis bundle (10), the inside of base (4) is hollow structure, one side of base (4) is fixed to be equipped with rather than inside first connecting pipe (7) that are linked together, just the opposite side of base (4) is fixed to be equipped with rather than inside second connecting pipe (9) that are linked together, closing plate (5) are fixed and install sealedly on the roof of base (4), ultrafiltration dialysis bundle (10) fixed mounting be in on the diapire of base (4), just the dialysis ultrafiltration bundle (10) with the inside of base (4) is linked together.

3. The in vivo reverse simple ultrafiltration dialysis device of claim 2, wherein: base (4) dorsad one side of first connecting pipe (7) is still fixed and is equipped with third connecting pipe (8) rather than inside being linked together, third connecting pipe (8) are kept away from the one end tip of base (4) still spiro union has heparin cap (23), it has first check valve (22) to go back fixed mounting on third connecting pipe (8), the direction that switches on of first check valve (22) dorsad heparin cap (23) set up.

4. The in vivo reverse simple ultrafiltration dialysis device of claim 2, wherein: the peripheral edge of base (4) still integratively is equipped with two fixing base (16), two fixing base (16) about first connecting pipe (7) symmetry sets up.

5. The in vivo reverse simple ultrafiltration dialysis device of claim 2, wherein: the outside of ultrafiltration dialysis bundle (10) still is equipped with ties up mechanism (11), it includes first connecting seat (12), second connecting seat (14) and cellosilk (13) to tie up mechanism (11), the fixed suit of first connecting seat (12) is in the outside of ultrafiltration dialysis bundle (10), just a terminal surface of first connecting seat (12) with the diapire fixed connection of base (4), the fixed suit of second connecting seat (14) is in ultrafiltration dialysis bundle (10) is kept away from the one end tip of base (4), just second connecting seat (14) dorsad embedded filter screen (15) of installing on the terminal surface of first connecting seat (12), cellosilk (13) are the heliciform winding and are in the outside of ultrafiltration dialysis bundle (10), the one end of cellosilk (13) with first connecting seat (12) fixed connection, and the other end of the fiber filament (13) is fixedly connected with the second connecting seat (14).

6. The in vivo reverse simple ultrafiltration dialysis device of claim 2, wherein: the ultrafiltration dialysis bundle (10) is composed of a plurality of semi-permeable membrane pipes (18), one ends of the semi-permeable membrane pipes (18) are open ends, the other ends of the semi-permeable membrane pipes (18) are closed ends, the open ends of the semi-permeable membrane pipes (18) are fixedly installed on the bottom wall of the base (4) through assembling seats (17), the closed ends of the semi-permeable membrane pipes (18) are semi-arc ends, and a plurality of support rings (19) which are arranged equidistantly are embedded in the pipe walls of the semi-permeable membrane pipes (18).

7. The in vivo reverse simple ultrafiltration dialysis device of claim 2, wherein: negative pressure generating unit (2) includes box body (29), lid (31), negative pressure pump (37), trachea (21), controller (35), battery (34), pressure sensor (6) and touch-control display screen (30), the rear portion of box body (29) is open structure, lid (31) fixed mounting be in the rear portion of box body (29), just a plurality of through-holes (38) have evenly been seted up on lid (31), negative pressure pump (37) fixed mounting be in the inside of box body (29), trachea (21) fixed mounting be in on the diapire of box body (29), just the one end of trachea (21) with the extraction opening of negative pressure pump (37) is fixed and communicate with each other and connect, the other end of trachea (21) through first connector (20) with first connecting pipe (7) are fixed and communicate with each other and connect, first connector (20) with first connecting pipe (7) are kept away from the one end threaded connection of base (4) is kept away from The controller (35) and the storage battery (34) are fixedly mounted inside the box body (29), the control output end of the controller (35) is electrically connected with the electric control end of the negative pressure pump (37), the storage battery (34) is respectively electrically connected with the controller (35) and the negative pressure pump (37), the pressure sensor (6) is embedded on the sealing plate (5), the sensing part of the pressure sensor (6) is communicated with the inside of the base (4), the signal output end of the pressure sensor (6) is electrically connected with the signal input end of the controller (35), the touch display screen (30) is mounted in the front of the box body (29) in an embedded mode, and the touch display screen (30) is electrically connected with the controller (35) in a two-way mode.

8. The in vivo reverse simple ultrafiltration dialysis device of claim 7, wherein: still be equipped with switch (32) and interface (33) that charge on the lateral wall of box body (29), switch (32) with interface (33) that charge all with battery (34) electric connection.

9. The in vivo reverse simple ultrafiltration dialysis device of claim 7, wherein: still fixed mounting has correlation type photoelectric sensor (39) on the interior diapire of box body (29), the transmitting terminal and the receiving terminal of correlation type photoelectric sensor (39) distribute in the both sides of trachea (21), just correlation type photoelectric sensor's (39) signal output part with the signal input part electric connection of controller (35), still fixed mounting has solenoid valve (40) on trachea (21), solenoid valve (40) are located correlation type photoelectric sensor (39) with between the extraction opening of negative pressure pump (37), just the automatically controlled end of solenoid valve (40) still with the control output part electric connection of controller (35).

10. The in vivo reverse simple ultrafiltration dialysis device of claim 7, wherein: the waste liquid drainage unit (3) comprises two second one-way valves (24), a flowmeter (25), a drainage tube (27), a liquid collecting bag (28) and a loudspeaker (36), wherein the two second one-way valves (24) are fixedly installed on the second connecting pipe (9), the conduction directions of the two second one-way valves (24) are back to the base (4), the flowmeter (25) is fixedly installed on the second connecting pipe (9), the flowmeter (25) is located between the two second one-way valves (24), the signal output end of the flowmeter (25) is electrically connected with the signal input end of the controller (35), one end of the drainage tube (27) is fixedly connected with the second connecting pipe (9) in a communicating manner through a second connector (26), the second connector (26) is connected with the second connecting pipe (9) in a threaded manner, the second connector (26) is back to one end of the connecting pipe (4), the other end of the drainage tube (27) is fixed and communicated with one end of the liquid collecting bag (28), the horn (36) is fixedly installed in the box body (29), and the electric control end of the horn (36) is electrically connected with the control output end of the controller (35).