CN111249508B - Indicator label, sterilization verification device assembly and method for judging sterilization effect - Google Patents

Indicator label, sterilization verification device assembly and method for judging sterilization effect Download PDF

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Publication number
CN111249508B
CN111249508B CN202010092766.2A CN202010092766A CN111249508B CN 111249508 B CN111249508 B CN 111249508B CN 202010092766 A CN202010092766 A CN 202010092766A CN 111249508 B CN111249508 B CN 111249508B
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China
Prior art keywords
sterilization
indicator
label
verification device
information
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CN202010092766.2A
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Chinese (zh)
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CN111249508A (en
Inventor
荣怀苹
李慧金
谌凌
唐文骏
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Shuwanuo Intellectual Property Co
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3M Innovative Properties Co
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/26—Accessories or devices or components used for biocidal treatment
    • A61L2/28—Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A61L2/06—Hot gas
    • A61L2/07—Steam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/14—Plasma, i.e. ionised gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/206—Ethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/208—Hydrogen peroxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps

Abstract

Indicator labels of the present disclosure are used in sterilization verification devices, such as for biological indicators. The indicating label is used for being adhered to the sterilization verification device, is in a flexible sheet shape and comprises an adhering surface and an information surface which are opposite; wherein the adhesive surface has an adhesive property such that the indicator label can be adhered to the sterilization verification device via the adhesive surface; the information surface is provided with a chemical indicating mark and readable marking information; the marking information is used for marking the sterilization verification device where the indication label is located; the chemical indicator mark can change in appearance to indicate the sterilization effect of the sterilization verification device; at least one part of the indicating label is a separating part, and the chemical indicating mark and the marking information are positioned on the separating part; the separating portion can be completely removed from the sterilization verification device, and the side of the separating portion facing away from the chemical indicator and the marking information can remain sticky at least after the separating portion is removed from the sterilization verification device for the first time.

Description

Indicator label, sterilization verification device assembly and method for judging sterilization effect
Technical Field
The embodiment of the invention belongs to the technical field of medical treatment, and particularly relates to an indication label, a sterilization verification device assembly and a method for judging sterilization effect.
Background
Medical devices are generally sterilized (disinfected) prior to use to avoid infection or the like due to contamination of the medical device.
To determine the specific effect of Sterilization on a medical instrument, a Sterilization verification device (Sterilization device) may be used, such as a Biological Indicator (BI). Specifically, the biological indicator (sterilization verification device) and the medical instrument can be sterilized together, the biological indicator is provided with a chemical indicator mark and spores, the chemical indicator mark and the spores can be changed in the sterilization process, and the sterilization effect of the biological indicator can be determined by observing the states of the chemical indicator mark and the spores after sterilization, namely determining whether the medical instrument corresponding to the biological indicator is sterilized and whether the sterilization achieves the expected effect.
Disclosure of Invention
The embodiment of the invention provides an indication label, a sterilization verification device assembly and a method for judging sterilization effect, which are convenient for tracing the sterilization process of a biological indicator.
In a first aspect, embodiments of the present invention provide an indicator label for adhering to a sterilization verification device, the indicator label being in the form of a flexible sheet comprising opposing adhesive and information sides; wherein the content of the first and second substances,
the adhesive surface has an adhesive property such that the indicator label can be adhered to the sterilization verification device by the adhesive surface;
the information surface is provided with a chemical indicating mark and readable marking information; the marking information is used for marking the sterilization verification device where the indication label is located; the chemical indicator mark can change in appearance to indicate the sterilization effect of the sterilization verification device;
at least a portion of the indicator label is a separation portion on which the chemical indicator and the marking information are located; the separation part can be completely removed from the sterilization verification device, and the side of the separation part, which faces away from the chemical indicator mark and the marking information, is still sticky at least after the separation part is removed from the sterilization verification device for the first time.
In some embodiments, the entirety of the indicator tab is the separate portion.
In some embodiments, the indicator tag further comprises a body portion;
the bonding surface is positioned on one side of the main body part;
the separating part is bonded to the main body part on the side away from the bonding surface.
In some embodiments, a surface of the main body portion, which is in contact with the separating portion on a side thereof facing away from the adhering surface, is a release surface.
In some embodiments, the identification information includes at least one of a bar code, a two-dimensional code, and a number for identifying the sterilization verification device on which the indicator label is located.
In some embodiments, the information plane is further provided with at least one item of additional information; each item of the additional information comprises an item name and a reserved space for filling in content corresponding to the item name, and the additional information is information related to a sterilization process of the sterilization verification device where the indication label is located;
the additional information is located on the separate portion.
In some embodiments, the indicator label has a breathable zone comprised of a breathable film;
the sterilization verification device is a biological indicator, and the label is used for the year on a containing unit of the biological indicator;
when the indication label is adhered on the accommodating unit, the ventilation area is used for corresponding to the ventilation opening of the accommodating unit.
In some embodiments, the indicator tag further comprises a body portion;
the bonding surface is positioned on one side of the main body part, and the ventilation area is arranged on the main body part;
the separating part is bonded to a position of the main body part on the side away from the bonding surface, which is not in the air-permeable area.
In a second aspect, embodiments of the present disclosure provide a sterilization verifier device assembly, comprising:
a sterilization verification device;
an indicator label in the form of a flexible sheet comprising opposed adhesive and information sides; wherein the content of the first and second substances,
the adhesive surface through which the indicator label is adhered to the sterilization verification device has tackiness;
the information surface is provided with a chemical indicating mark and readable marking information; the marking information is used for marking the sterilization verification device; the chemical indicator mark can generate appearance change to indicate the sterilization effect of the sterilization verification device;
at least a portion of the indicator label is a separation portion on which the chemical indicator and the marking information are located; the separation part can be completely removed from the sterilization verification device, and the side of the separation part, which faces away from the chemical indicator mark and the marking information, is still sticky at least after the separation part is removed from the sterilization verification device for the first time.
In some embodiments, the entirety of the indicator tab is the separate portion.
In some embodiments, the surface of the sterilization verification device in contact with the indicator tag is an off-profile surface.
In some embodiments, the indicator tag further comprises a body portion;
the bonding surface is positioned on one side of the main body part;
the separating part is bonded to the main body part on the side away from the bonding surface.
In some embodiments, a surface of the main body portion, which is in contact with the separating portion on a side thereof facing away from the adhering surface, is a release surface.
In some embodiments, the identification information includes at least one of a bar code, a two-dimensional code, and a number for identifying the sterilization verification device.
In some embodiments, the information plane is further provided with at least one item of additional information; each item of the additional information comprises an item name and a reserved space for filling out content corresponding to the item name, and the additional information is information related to a sterilization process of the sterilization verification device;
the additional information is located on the separate portion.
In some embodiments, the sterilization verification device is a biological indicator, the indicator label being adhered to a containment unit of the biological indicator;
the accommodating unit is provided with an inner space and a ventilation port communicated with the inner space, and spores are arranged in the inner space and can be killed when the biological indicator is sterilized to indicate the sterilization effect.
In some embodiments, the indicator label covers the ventilation opening, and the position of the indicator label corresponding to the ventilation opening is a ventilation region composed of a breathable film.
In some embodiments, the indicator tag further comprises a body portion;
the bonding surface is positioned on one side of the main body part, and the ventilation area is arranged on the main body part;
the separating part is bonded to a position of the main body part on the side away from the bonding surface, which is not in the air-permeable area.
In some embodiments, the housing unit includes:
a body defining the interior space and having an opening;
the cover body is arranged on the opening of the body and can be separated from the body, and the ventilation port is arranged on the cover body;
the indicator label is adhered to the cover.
In some embodiments, the cover body is provided with a top part opposite to the opening of the body and a side part connected with the edge of the top part, and the ventilation opening is arranged on the side part;
the indication label is adhered to the side part and covers the ventilation opening, and the position of the indication label corresponding to the ventilation opening is a ventilation area formed by a ventilation film.
In some embodiments, the housing unit further comprises:
the ampoule is arranged in the inner space and is provided with a culture solution, and when the cover body moves relative to the body, the ampoule can be broken to release the culture solution in the ampoule;
a spore carrier carrying the spores, the spores on the spore carrier being capable of contacting the culture fluid when the ampoule releases the culture fluid.
In a third aspect, an embodiment of the present invention provides a method for determining sterilization effect, including:
sterilizing a sterilization verification device assembly together with an article to be sterilized, the sterilization verification device assembly being any one of the above-described sterilization verification device assemblies;
judging the sterilization effect through the chemical indicator and the sterilization verification device;
and removing the separated part of the indicator label from the sterilization verification device, and adhering the separated part to the record carrier through the side of the separated part, which is far away from the chemical indicator mark and the marking information.
In some embodiments, the sterilization comprises at least one of pressure steam sterilization, low temperature hydrogen peroxide plasma sterilization, ethylene oxide sterilization.
The indication label provided by the embodiment of the invention is provided with the chemical indication label and the marking information at the same time, so that the sterilization verification device corresponding to the indication label can be directly determined through the marking information, and further the sterilization condition of the corresponding medical instrument can be directly determined. Meanwhile, the chemical indicator and the label information (separation part) can be easily taken off from the sterilization verification device and attached to a recording carrier such as a notebook without tearing, so that the sterilization process information can be conveniently stored.
Drawings
FIG. 1 is a schematic structural diagram of an indicator tag according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of another indicator tag according to an embodiment of the present invention;
FIG. 3 is a schematic structural view of a housing unit in a biological indicator according to an embodiment of the invention;
FIG. 4 is a schematic diagram of a sterilization verifier device assembly according to an embodiment of the present disclosure;
FIG. 5 is a flow chart of a method for determining sterilization effectiveness according to an embodiment of the present invention;
wherein the reference numerals are: 1. an accommodating unit; 11. a body; 12. a cover body; 13. a ventilation opening; 14. an ampoule; 141. a culture solution; 15. a spore carrier; 16. a filter structure; 19. an interior space; 2. an indicator label; 21. a chemical indicator; 22. marking information; 23. a breathable zone; 24. additional information; 28. a main body portion; 29. a separation section.
Detailed Description
In order to make the technical solutions of the present invention better understood by those skilled in the art, the following detailed description of the embodiments of the present invention is provided with reference to the accompanying drawings.
It is to be understood that the specific embodiments and figures described herein are merely illustrative of the embodiments of the invention and are not limiting of the invention.
It is to be understood that the embodiments and features of the embodiments may be combined with each other without conflict.
It is to be understood that, for the convenience of description, only parts related to the present invention are shown in the drawings of the present invention, and parts not related to the present invention are not shown in the drawings.
In a first aspect, and with reference to fig. 1-4, an embodiment of the present invention provides an indicator label 2 for use in bonding a sterilization verification device, the indicator label 2 being in the form of a flexible sheet comprising opposing bonding and information sides; wherein the content of the first and second substances,
the adhesive surface has adhesive properties so that the indicator label 2 can be adhered to the sterilization verification device via the adhesive surface;
the information surface is provided with chemical indicating marks 21 and readable marking information 22; the indication information 22 indicates the sterilization verification apparatus in which the indication label 2 is located; the chemical indicator 21 can change in appearance to indicate the sterilization effect of the sterilization verification device;
at least one part of the indicating label 2 is a separating part 29, and the chemical indicating mark 21 and the marking information 22 are positioned on the separating part 29; the separating portion 29 can be completely removed from the sterilization verification device and the side of the separating portion 29 facing away from the chemical indicator 21 and the identifying information 22 remains tacky at least after the first removal of the separating portion 29 from the sterilization verification device.
Medical instruments are generally sterilized (disinfected) before use to ensure cleanliness and avoid infection of the human body caused by the medical instruments.
Since the medical instrument has a complicated structure and it is difficult to visually distinguish whether or not the sterility level is reached after sterilization, it is difficult to directly detect whether or not the medical instrument is sterile after each sterilization. Meanwhile, due to the fluctuation of the environment (such as temperature and humidity), the performance of the sterilization equipment, and the like, the same sterilization process cannot always achieve the same sterilization effect.
Therefore, in order to ensure that the sterilized medical devices have the desired degree of cleanliness, the actual effect of each sterilization (i.e., the actual sterilization effect achieved by the sterilization process) needs to be evaluated.
To specifically evaluate the sterilization effect, the sterilization verification apparatus may be sterilized together with the medical instrument, and the sterilization effect may be evaluated by observing the state of the sterilization verification apparatus.
In some embodiments, the sterilization verification device may be embodied as a biological indicator, and the indicator tag 2 is intended to be glued to the housing unit 1 of the biological indicator.
The following description will be given taking the sterilization verification apparatus as a biological indicator.
The biological indicator is provided with a containing unit 1, spores are arranged in the containing unit 1 and can be killed in the sterilization process, and therefore the sterilization effect of the biological indicator can be determined by observing the states of the spores (such as the number of the spores or the content of fluorescent active substances) after sterilization. Since the biological indicator is sterilized together with the medical instrument, the sterilization effect of both should be the same, and thus determining the sterilization effect of the biological indicator is also a determination of the sterilization effect of the medical instrument.
Since observation of spores is difficult (e.g., culture, microscopic observation, etc. are required) and it is often difficult to quickly interpret the kill of spores, indicator label 2 of the present embodiment can be attached to housing unit 1 to determine whether biological indicators are sterilized immediately after sterilization is completed and to preliminarily determine the effectiveness of sterilization. The indicator label 2 resembles a "label paper" having two sides, one of which is an adhesive side having adhesive properties (e.g. provided with an adhesive) and the other of which is an information-bearing side.
Referring to fig. 2, the information plane has chemical indicating marks 21 thereon. The chemical indicator 21 is a pattern-specific, color-specific mark (e.g., a dot) containing a substance that reacts chemically when exposed to the sterilization gas, such as a reactive system containing sulfur and bismuth salicylate, which reacts chemically during sterilization and undergoes a visible, distinct color change after reaction.
The chemical indicator 21 may have a visible appearance change (such as a color change, a brightness change, a pattern change, etc.) during the sterilization process due to the chemical reaction of the substance, and by observing the change of the chemical indicator 21, it can be determined whether the biological indicator (sterilization verification device) is sterilized and preliminarily judge the sterilization effect.
Meanwhile, the indication label 2 is provided with readable indication information 22, and the indication information 22 is used for indicating (or distinguishing) the biological indicator where the indication label 2 is located. Due to the marking information 22, the biological indicator corresponding to the marking information can be directly determined through the indicating label 2 without additional recording, and the tracing of the sterilization process is convenient to realize.
After the sterilization is finished, the chemical indicator 21 and the indication information 22 should be saved as a record to trace back the sterilization process. For this reason, in the indicator label 2 of the embodiment of the present invention, at least the portion having the chemical indicator 21 and the indication information 22 (i.e., the separation portion 29, so that the surface of the separation portion 29 having the chemical indicator 21 and the indication information 22 belongs to the information surface) should be completely removed from the housing unit 1, and the back surface of the separation portion 29 should maintain a certain viscosity after being removed, so as to adhere the separation portion 29 (including the chemical indicator 21 and the indication information 22 thereon) to a recording medium such as a notebook, and keep the recording of the sterilization process.
Here, "complete peeling" means that the peel strength of the separating portion 29 should be smaller than that of itself so that the separating portion 29 can be easily peeled off from the containing unit 1 without being damaged; alternatively, the separating portion 29 should be "peelable".
The indication label 2 of the embodiment of the invention is provided with the chemical indication mark 21 and the marking information 22 at the same time, so that the biological indicator corresponding to the indication label 2 can be directly determined through the marking information 22, and further the sterilization condition of the corresponding medical instrument can be directly determined. Meanwhile, the chemical indicating mark 21 and the indicating information 22 (the separating part 29) can be easily removed from the housing unit 1 and attached to a recording medium such as a notebook without tearing or the like, so that the information of the sterilization process can be conveniently stored.
In some embodiments, the identification information 22 includes at least one of a bar code, a two-dimensional code, a number for identifying the biological indicator.
Referring to fig. 2, the identification information 22 may be in the form of a two-dimensional code or the like readable by a machine; alternatively, the identifying information 22 may be in the form of a number (e.g., a number and/or letter) that can be read manually.
Of course, other forms of the identifying information 22 are possible, such as where the identifying information 22 comprises a magnetic substance such as a magnetic strip that carries information.
In some embodiments, the information plane is further provided with at least one item of additional information 24; each item of additional information 24 comprises an item name and a reserved space for filling in content corresponding to the item name, the additional information 24 being information relating to the sterilization process of the biological indicator in which the indicator tag 2 is located; the additional information 24 is located on the separating section 29.
Referring to fig. 2, some information related to the sterilization process of the biological indicator may be determined after the sterilization is completed, and it is also important to record the information. For this reason, it is convenient to record the item name corresponding to the information on the information surface of the instruction label 2 and to provide a space for filling in the content corresponding to the item name, but in this case, the additional information 24 should be located on the separating part 29, so that the relevant content can be directly filled in after the separating part 29 is attached to the notebook.
For example, the additional information 24 may include a Sterilizer number (Sterilizer No.), a sterilization Date (Date), an Operator (Operator), a sterilization Result (Result), a Sterilizer Load (Load) (i.e., the number of sterilization operations performed by the Sterilizer on the day).
Of course, other information, such as company name, product name, etc. (AAAA in FIG. 2), can also be carried on the information planeTMBBBB BI, etc.), and these information are not directly related to the sterilization process and therefore may not be located on the separation section 29 and will not be described in detail herein.
In some embodiments, indicator label 2 has a breathable zone 23 comprised of a breathable film; the ventilation zone 23 is intended to correspond to the ventilation opening 13 of the containing unit 1 when the indicator label 2 is adhered to the containing unit 1.
The housing unit 1 of the biological indicator needs to be provided with a gas permeable port 13 in order to bring the sterilizing gas into contact with the spores. Referring to fig. 4, when the indication label 2 is attached to the containing unit 1, the ventilation opening 13 may be covered, so the indication label 2 needs to have a ventilation area 23 (as shown in fig. 2) corresponding to the ventilation opening 13, and the ventilation area 23 is made of a ventilation film, so that the sterilization gas can be allowed to pass through and the containing unit 1 can be ensured to be relatively closed.
In one aspect of the embodiment of the present invention, the entire indicator tag 2 is the separation portion 29.
Referring to fig. 1, as a possible way, the indication label 2 may be just the separation part 29, that is, the indication label 2 (separation part 29) as a whole may be completely peeled off from the containing unit 1.
It should be understood that "the label 2 comprises an adhesive face and an information face opposite to each other" means that the label 2 is provided as a sheet, the two opposite sides of which are the adhesive face and the information face, respectively, of the whole. Therefore, when the whole of the instruction label 2 is the separating portion 29, the surfaces on both sides of the separating portion 29 are the adhesive surface and the information surface: the side of the separating portion 29 having the chemical indicator marks 21 and the indication information 22 is the information side of the indicator label 2, and the side of the separating portion 29 away from the chemical indicator marks 21 and the indication information 22 is the adhesive side of the indicator label 2, so that the adhesive side should have proper adhesiveness, and the indicator label 2 as a whole should have sufficient strength to ensure that the indicator label 2 (the separating portion 29) as a whole can be completely peeled off.
As another way of the embodiment of the present invention, the indication tag 2 further includes a main body portion 28; the bonding surface is located on one side of the main body portion 28; the separating portion 29 is bonded to the main body portion 28 on the side away from the bonding surface.
Referring to fig. 2, as another possible way, the indicating label 2 may be divided into two layers stacked "one on top of the other", namely, a main body 28 and a separating portion 29, wherein the main body 28 is directly bonded to the containing unit 1 by the above bonding surface, and the separating portion 29 is bonded to the main body 28, so that the separating portion 29 can be actually completely peeled off from the main body 28 (and certainly from the containing unit 1) and separately bonded to a recording medium such as a notebook.
Thus, the main body 28 has one side serving as an adhesive surface of the indicator label 2; the side of the separating portion 29 facing away from the main body portion is the information surface of the indicator label 2, and the side of the main body portion 28 facing away from the adhesive surface is the information surface of the indicator label 2 if there is a portion not covered by the separating portion 29.
Of course, the side of the separating portion 29 in contact with the main body portion 28 should have appropriate tackiness (but this side is not the adhesive surface of the indicator label 2), and the separating portion 29 should have sufficient strength.
In the above manner, the strength of the adhesive bond between the indicator label 2 and the containing unit 1 can be high (e.g., permanent adhesive bond) to ensure that the indicator label 2 does not accidentally fall off during the sterilization process.
In some embodiments, the surface of the body portion 28 that is in contact with the separating portion 29 on the side facing away from the adhesive surface is a release surface.
The release surface is a surface made of a release material, such as a surface of a release film or a release paper. The characteristics of the release surface are: other structures may be adhesively bonded to the release surface, but the bond has a low peel strength, allowing for easy separation of the other structures from the release surface without damaging the other structures or significantly leaving adhesive on the release surface during the separation process.
In the above manner, at least the surface of the main body 28 in contact with the separating portion 29 is a release surface (of course, the whole surface may be a release surface), that is, the separating portion 29 is bonded to the release surface, so that the separating portion can be easily removed completely.
Referring to fig. 2, in some embodiments, the breathable zone 23 is provided on the main body portion 28, and the separating portion 29 is bonded to a side of the main body portion 28 facing away from the bonding surface at a location not belonging to the breathable zone 23.
When the indicator label 2 is divided into the main body portion 28 and the separating portion 29 and has the ventilation region 23, the ventilation region 23 should be provided on the main body portion 28, that is, a part of the main body portion 28 is a ventilation film, and the separating portion 29 should be bonded to a part of the main body portion 28 which is not a ventilation film, so as not to affect ventilation.
Of course, the main body 28 may have the above release surface, for example, the surface of the main body 28 facing away from the bonding surface except the ventilation zone 23 may be the release surface.
In a second aspect, referring to fig. 4, an embodiment of the present disclosure provides a sterilization verifier device assembly, comprising:
a sterilization verification device;
the above-described indicator label 2 is bonded to the sterilization verification device.
In some embodiments, the sterilization verification device may be a biological indicator and the indicator tag 2 may be adhered to the housing unit 1 of the biological indicator.
The following description will be given taking the sterilization verification apparatus as a biological indicator.
Wherein, the containing unit 1 is provided with an inner space 19 and a ventilation port 13 communicated with the inner space 19, the inner space 19 is provided with spores which can be killed to indicate the sterilization effect when the biological indicator is sterilized.
The biological indicator of the embodiment of the invention is provided with the containing unit 1, the containing unit 1 can form a relatively closed inner space 19 inside, and spores are arranged in the inner space 19. Furthermore, the containing unit 1 has a gas permeable port 13 for communicating the inner space 19 with the outside for the sterilizing gas to enter the inner space 19 to contact the spores.
Since the indicator label 2 is provided, the separating part 29 can be easily detached and attached to a recording medium such as a notebook after sterilization, and information on the sterilization process of the biological indicator can be stored.
In some embodiments, when the indicator label 2 is entirely the separation portion 29, the surface of the containing unit 1 contacting the indicator label 2 is a release surface, i.e. the indicator label 2 is actually adhered to the release surface, so that it is easy to remove the whole from the containing unit 1.
In some embodiments, the housing unit 1 includes: a body 11 defining an inner space 19 and having an opening; a cover body 12 provided on the opening of the body 11, which can be separated from the body 11, and a ventilation opening 13 provided on the cover body 12; the indicator label 2 is bonded to the cover 12.
Referring to fig. 3, the containing unit 1 is entirely in the form of a "vial" to form the above internal space 19. Wherein the bottle body (body 11) can be a Plastic sleeve (Plastic sleeve) with an opening, and the inner space 19 is formed in the bottle body; the cap (cover 12) may be a Plastic cap (Plastic cap) that covers the opening of the bottle body, and the cap may be removed from the bottle body to take out the spore through the opening.
In some embodiments, the containing unit 1 further comprises:
an ampoule 14 (i.e., an ampoule bottle) disposed in the inner space 19, wherein a culture solution 141 (i.e., a biological culture solution) is disposed, and when the cover 12 moves relative to the body 11, the ampoule 14 can be ruptured to release the culture solution 141 therein;
the spore carrier 15 carries spores, and when the ampoule 14 releases the culture solution 141, the spores on the spore carrier 15 can contact the culture solution 141.
After the sterilization, the number of spores may be small even if the spores remain, and it is difficult to directly detect the remaining spores, so that the spores can be cultured after the sterilization and then detected.
Specifically, spores can be located on the spore carrier 15, and the spores can contact the culture solution 141 after sterilization is finished, and if the spores are not completely killed and survive, the spores can be propagated in the culture solution 141 in large quantities. Therefore, after a certain time, the culture solution 141 is detected by using an interpretation instrument: if the detection shows that the spores which are not killed exist in the culture solution 141, the sterilization failure is indicated; successful sterilization is indicated if no viable spores are detected in the culture solution 141.
To prevent the spores from contacting the culture solution 141 and starting to reproduce in advance before the start of sterilization, the spores should be isolated from the culture solution 141. Referring to fig. 3, in order to facilitate the preservation of the culture solution 141, a Glass ampoule (Glass ampoule) may be disposed in the body 11, and the culture solution 141 may be sealed therein for preservation. Meanwhile, a corresponding structure is provided in the cover 12, so that after the sterilization is finished, the cover 12 can be moved (e.g., pressed) relative to the body 11 to break (e.g., squeeze, crush, etc.) the ampoule 14, so that the culture solution 141 therein is released into the inner space 19 of the body 11 and contacts with the spores on the Spore carrier 15 (spoore carrier), and the sterilization effect is indicated through the subsequent detection.
Illustratively, the ampoule 14 in the biological indicator contains the culture solution 141, when the cover 12 of the containing unit 1 is pressed downwards, the ampoule 14 is broken, and the culture solution 141 in the ampoule 14 is contacted with the spores on the spore carrier 15 to provide nutrients for the spores. The spore carrier 15 may be in various forms such as a sheet, a circle, etc.
Wherein, between the ampoule 14 and the spore carrier 15, a filtering structure 16, such as a non-woven filter cloth (non woven fi filter), may be further provided to filter the culture solution 141 released from the ampoule 14, so as to avoid the contact of glass fragments and the like with the spores on the spore carrier 15, which may affect the culture effect.
In some embodiments, the cover 12 has a top opposite to the opening of the body 11, and a side connected to the edge of the top, and the ventilation opening 13 is provided at the side;
the indication label 2 is adhered on the side part and covers the ventilation port 13, and the position of the indication label 2 corresponding to the ventilation port 13 is a ventilation area 23 composed of a ventilation film.
Since the indication label 2 is provided with the indication information 22 and the like, it has a large area and thus needs to be attached to a large surface. Referring to fig. 4, the side of cover 12 opposite the top of cover 12 (corresponding to the top surface of the cylinder) is annular (corresponding to the side of the cylinder) and has a greater surface area so that indicator label 2 can be adhered to the side; meanwhile, the ventilation opening 13 can be arranged on the side part of the cover body 12, and the indication label 2 blocks the ventilation opening 13 (the ventilation area 23 corresponding to the ventilation opening 13 needs to be arranged in the indication label 2), so that the ventilation opening 13 can be sealed (the air is allowed to pass through of course) through the indication label 2 without separately arranging other sealing structures.
Of course, it should be understood that the above housing unit 1, the structure in the housing unit 1, the arrangement position of the indication label 2, and the like are all illustrative and not limiting to the scope of the present invention.
In a third aspect, referring to fig. 5, an embodiment of the present invention provides a method for determining sterilization effect, which includes at least the following steps:
s101, sterilizing the components (such as the biological indicator and the indicator label) of the sterilization verification device and the articles to be sterilized.
And S102, judging the sterilization effect through a chemical indicator and a sterilization verification device (such as a biological indicator containing spores).
S103, detaching the separation part of the indicator label from the sterilization verification device (e.g., the housing unit of the biological indicator), and adhering the separation part to the record carrier through a side of the separation part facing away from the chemical indicator and the identification information.
In the method for judging the sterilization effect according to the embodiment of the present invention, the biological indicator (sterilization verification device) and the article to be sterilized are sterilized together, for example, by using a sterilization gas. During the sterilization process, the sterilization gas causes the change of the chemical indicator marks and enters the inner space of the containing unit through the ventilation port to contact with the spores, so that the spores are killed, and the change of the spores is caused. Therefore, whether the corresponding article to be sterilized is sterilized or not and how the sterilization effect is can be judged by observing the chemical indicator marks and the spores. Thereafter, the separate part of the indicator label is removed and glued to the record carrier to retain the information of the sterilization process.
In some embodiments, the sterilization is a gas phase sterilization, specifically including at least one of a steam under pressure (steam) sterilization, a low temperature hydrogen peroxide (hydrogen peroxide) plasma sterilization, an Ethylene Oxide (EO) sterilization. Of course, the method is also applicable to processes using other gases for sterilization.
In some embodiments, the article to be sterilized comprises a medical instrument.
The sterilization requirements for medical devices are generally high and are therefore particularly suitable for use in the methods of the embodiments of the present invention. Of course, the method of the embodiments of the present invention is also applicable to sterilization of other articles such as cosmetic devices.
In some embodiments the record carrier comprises at least one of a record book, a recording paper, a recording card.
That is, after the separating portion is removed, it may be attached to a notebook (e.g., a notebook), a recording sheet, a recording card, or the like, to preserve the sterilization results.
Of course, it is also possible that the separating portion is attached to another record carrier.
It will be understood that the above embodiments are merely exemplary embodiments taken to illustrate the principles of the present invention, which is not limited thereto. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit and substance of the invention, and these modifications and improvements are also considered to be within the scope of the invention.

Claims (20)

1. An indicator label for adhering to a sterilization verification device, the indicator label being in the form of a flexible sheet comprising opposed adhesive and information sides; wherein the content of the first and second substances,
the adhesive surface has an adhesive property such that the indicator label can be adhered to the sterilization verification device by the adhesive surface;
the information surface is provided with a chemical indicating mark and readable marking information; the marking information is used for marking the sterilization verification device where the indication label is located; the chemical indicator mark can change in appearance to indicate the sterilization effect of the sterilization verification device;
at least a portion of the indicator label is a separation portion on which the chemical indicator and the marking information are located; the separation part can be completely removed from the sterilization verification device, and the side of the separation part, which is far away from the chemical indicator mark and the marking information, still keeps viscosity at least after the separation part is removed from the sterilization verification device for the first time;
the indicator label has a breathable zone comprised of a breathable film;
the sterilization verification device is a biological indicator, and the indication label is used for being adhered to a containing unit of the biological indicator;
when the indication label is adhered on the accommodating unit, the ventilation area is used for corresponding to the ventilation opening of the accommodating unit.
2. The indicator tag of claim 1, wherein,
the whole of the indicator label is the separation part.
3. The indicator tag of claim 1, further comprising a body portion;
the bonding surface is positioned on one side of the main body part;
the separating part is bonded to the main body part on the side away from the bonding surface.
4. The indicator tag of claim 3, wherein,
the surface of the main body part, which is away from one side of the bonding surface and is contacted with the separation part, is a release surface.
5. The indicator tag of claim 1, wherein,
the marking information comprises at least one of a bar code, a two-dimensional code and a serial number used for marking the sterilization verification device where the indication label is located.
6. The indicator tag of claim 1, wherein,
the information surface is also provided with at least one item of additional information; each item of the additional information comprises an item name and a reserved space for filling in content corresponding to the item name, and the additional information is information related to a sterilization process of the sterilization verification device where the indication label is located;
the additional information is located on the separate portion.
7. The indicator tag of claim 1, further comprising a body portion;
the bonding surface is positioned on one side of the main body part, and the ventilation area is arranged on the main body part;
the separating part is bonded to a position of the main body part on the side away from the bonding surface, which is not in the air-permeable area.
8. A sterilization verifier device assembly comprising:
a sterilization verification device;
an indicator label in the form of a flexible sheet comprising opposed adhesive and information sides; wherein the content of the first and second substances,
the adhesive surface through which the indicator label is adhered to the sterilization verification device has tackiness;
the information surface is provided with a chemical indicating mark and readable marking information; the marking information is used for marking the sterilization verification device; the chemical indicator mark can change in appearance to indicate the sterilization effect of the sterilization verification device;
at least a portion of the indicator label is a separation portion on which the chemical indicator and the marking information are located; the separation part can be completely removed from the sterilization verification device, and the side of the separation part, which is far away from the chemical indicator mark and the marking information, still keeps viscosity at least after the separation part is removed from the sterilization verification device for the first time;
the sterilization verification device is a biological indicator, and the indication label is adhered to a containing unit of the biological indicator;
the accommodating unit is provided with an inner space and a ventilation port communicated with the inner space, and spores are arranged in the inner space and can be killed when the biological indicator is sterilized to indicate the sterilization effect;
the indication label covers the ventilation opening, and the position of the indication label corresponding to the ventilation opening is a ventilation area formed by a ventilation film.
9. The sterilization verifier device assembly of claim 8,
the whole of the indicator label is the separation part.
10. The sterilization verifier device assembly of claim 9, wherein,
the surface of the sterilization verification device in contact with the indicator label is an off-type surface.
11. The sterilization verifier device assembly of claim 8, wherein the indicator tag further comprises a body portion;
the bonding surface is positioned on one side of the main body part;
the separating part is bonded to the main body part on the side away from the bonding surface.
12. The sterilization verifier device assembly of claim 11, wherein,
the surface of the main body part, which is away from one side of the bonding surface and is contacted with the separation part, is a release surface.
13. The sterilization verifier device assembly of claim 8,
the marking information includes at least one of a bar code, a two-dimensional code, and a serial number for marking the sterilization verification device.
14. The sterilization verifier device assembly of claim 8,
the information surface is also provided with at least one item of additional information; each item of the additional information comprises an item name and a reserved space for filling out content corresponding to the item name, and the additional information is information related to a sterilization process of the sterilization verification device;
the additional information is located on the separate portion.
15. The sterilization verifier device assembly of claim 8, wherein the indicator tag further comprises a body portion;
the bonding surface is positioned on one side of the main body part, and the ventilation area is arranged on the main body part;
the separating part is bonded to a position of the main body part on the side away from the bonding surface, which is not in the air-permeable area.
16. The sterilization verifier device assembly of claim 8, wherein the containment unit comprises:
a body defining the interior space and having an opening;
the cover body is arranged on the opening of the body and can be separated from the body, and the ventilation port is arranged on the cover body;
the indicator label is adhered to the cover.
17. The sterilization verifier device assembly of claim 16, wherein,
the cover body is provided with a top part opposite to the opening of the body and a side part connected with the edge of the top part, and the ventilation port is arranged on the side part;
the indication label is adhered to the side part and covers the ventilation opening, and the position of the indication label corresponding to the ventilation opening is a ventilation area formed by a ventilation film.
18. The sterilization verifier device assembly of claim 16, wherein the containment unit further comprises:
the ampoule is arranged in the inner space and is provided with a culture solution, and when the cover body moves relative to the body, the ampoule can be broken to release the culture solution in the ampoule;
a spore carrier carrying the spores, the spores on the spore carrier being capable of contacting the culture fluid when the ampoule releases the culture fluid.
19. A method of determining the effectiveness of sterilization, comprising:
sterilizing a sterilization verifier device assembly together with an item to be sterilized, the sterilization verifier device assembly being as defined in any one of claims 8 to 18;
judging the sterilization effect through the chemical indicator and the sterilization verification device;
and removing the separated part of the indicator label from the sterilization verification device, and adhering the separated part to the record carrier through the side of the separated part, which is far away from the chemical indicator mark and the marking information.
20. The method of judging sterilization effect according to claim 19,
the sterilization comprises at least one of pressure steam sterilization, low-temperature hydrogen peroxide plasma sterilization and ethylene oxide sterilization.
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115565652B (en) * 2022-09-14 2023-10-20 深圳市安保医疗感控科技股份有限公司 Chemical indication-based multiplexing medical instrument package sterilization management method and system

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003085397A2 (en) * 2002-04-02 2003-10-16 Cmc Daymark Corporation Plural intrinsic expiration initiation application indicators
CN201959282U (en) * 2011-01-25 2011-09-07 山东医学高等专科学校 Autoclave indicator tape
CN202058371U (en) * 2011-05-09 2011-11-30 谭晓卫 Tracing sterilization chemical instruction label
CN102326076A (en) * 2008-12-31 2012-01-18 3M创新有限公司 Chemical indicator composition, indicators and methods
CN102460148A (en) * 2009-05-08 2012-05-16 巴斯夫欧洲公司 Indicator system for monitoring a sterilization process
CN103282772A (en) * 2010-12-22 2013-09-04 3M创新有限公司 Sterilization indicators including a neutralizer and methods
CN103910956A (en) * 2012-12-31 2014-07-09 3M创新有限公司 Chemical indication composition, steam sterilization indication tape and manufacturing method thereof
CN104548171A (en) * 2015-02-09 2015-04-29 淄博亘泽精细化工有限公司 Preparation method of moist-heat sterilization chemical indication card
CN204330578U (en) * 2015-01-08 2015-05-13 淄博亘泽精细化工有限公司 Moist heat sterilization Chemical indicative card label
CN209075578U (en) * 2017-11-10 2019-07-09 深圳洁康医疗器材有限公司 A kind of biological indicator outer tube
CN209674721U (en) * 2019-05-29 2019-11-22 河南弘辉医疗科技有限公司 A kind of moist heat sterilization chemistry indicating label

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8727957B2 (en) * 2010-08-05 2014-05-20 Kimberly-Clark Worldwide, Inc. System for securing flexible multi-panel sterilization assembly
EP2654808A1 (en) * 2010-12-22 2013-10-30 3M Innovative Properties Company Sterilization indicators including a porous carrier and methods
CN202446527U (en) * 2011-11-09 2012-09-26 同济大学第一附属中学 Sterilizing sticker
US20140271345A1 (en) * 2013-03-15 2014-09-18 Michael Pavesi Sterilization Indicator Tapes, Labels and other Apparatus Made Free of Cellulose, Latex, Lead and Heavy Metals
JP6676647B2 (en) * 2014-10-30 2020-04-08 クライオヴァック，インコーポレイテッド Self-sterilizing package and method of making and using the same
CN207012358U (en) * 2016-12-09 2018-02-16 山东新华医疗器械股份有限公司 Pressure steam sterilizing chemical tracer card
CN208114832U (en) * 2017-11-26 2018-11-20 北京白象新技术有限公司 Steam sterilizing fast verification device containing Chemical indicative card and biological indicator
CN109395133A (en) * 2018-09-20 2019-03-01 南京巨鲨显示科技有限公司 A kind of pressuresteam sterilization indicant and preparation method thereof

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003085397A2 (en) * 2002-04-02 2003-10-16 Cmc Daymark Corporation Plural intrinsic expiration initiation application indicators
CN102326076A (en) * 2008-12-31 2012-01-18 3M创新有限公司 Chemical indicator composition, indicators and methods
CN102460148A (en) * 2009-05-08 2012-05-16 巴斯夫欧洲公司 Indicator system for monitoring a sterilization process
CN103282772A (en) * 2010-12-22 2013-09-04 3M创新有限公司 Sterilization indicators including a neutralizer and methods
CN201959282U (en) * 2011-01-25 2011-09-07 山东医学高等专科学校 Autoclave indicator tape
CN202058371U (en) * 2011-05-09 2011-11-30 谭晓卫 Tracing sterilization chemical instruction label
CN103910956A (en) * 2012-12-31 2014-07-09 3M创新有限公司 Chemical indication composition, steam sterilization indication tape and manufacturing method thereof
CN104902932A (en) * 2012-12-31 2015-09-09 3M创新有限公司 Chemical indicating composition, autoclave tape and method for preparing autoclave tape
CN204330578U (en) * 2015-01-08 2015-05-13 淄博亘泽精细化工有限公司 Moist heat sterilization Chemical indicative card label
CN104548171A (en) * 2015-02-09 2015-04-29 淄博亘泽精细化工有限公司 Preparation method of moist-heat sterilization chemical indication card
CN209075578U (en) * 2017-11-10 2019-07-09 深圳洁康医疗器材有限公司 A kind of biological indicator outer tube
CN209674721U (en) * 2019-05-29 2019-11-22 河南弘辉医疗科技有限公司 A kind of moist heat sterilization chemistry indicating label

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