CN111249236A - Preparation method and preparation device of insoluble special medical food powder for reducing high blood pressure, high blood sugar and high blood sugar - Google Patents

Preparation method and preparation device of insoluble special medical food powder for reducing high blood pressure, high blood sugar and high blood sugar Download PDF

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CN111249236A
CN111249236A CN202010063192.6A CN202010063192A CN111249236A CN 111249236 A CN111249236 A CN 111249236A CN 202010063192 A CN202010063192 A CN 202010063192A CN 111249236 A CN111249236 A CN 111249236A
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chamber
temperature
communicated
ultrasonic
vacuum
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周文虎
彭英
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Hunan Deyi Health Management Co Ltd
Changsha Yijiayi Biotechnology Co ltd
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Hunan Deyi Health Management Co Ltd
Changsha Yijiayi Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01D45/00—Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces
    • B01D45/12—Separating dispersed particles from gases or vapours by gravity, inertia, or centrifugal forces by centrifugal forces
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
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Abstract

The invention provides a preparation method and a preparation device of insoluble special medical food powder for reducing hypertension, hyperglycemia and hyperlipidemia, 1) insoluble materials and solubilizing solvents are subjected to ultrasonic dispersion and mixing to prepare solubilizing microspheres; 2) under the action of the air pressure of an inert gas pressure device, the solubilizing microspheres are sprayed out through a heating spray head and dried in a closed drying chamber at constant temperature to form mixed gas containing solid particles; 3) the mixed gas containing solid particles enters a size-regulating cyclone separation unit under the action of pressure to perform solid-vapor separation, and the solid particles fall into a collector to obtain solid powder; the gas is treated by a vacuum pump and condensed reflux and a vacuum system unit to recover the solubilization solvent, and the solubilization solvent returns to the solubilization solvent preparation unit under the action of the vacuum pump. The preparation method is characterized in that the difficult-to-hold material is ultrasonically prepared into microspheres, and vacuum constant-temperature drying is combined on the basis of spray drying, so that the particle size of the material is ensured, the solubility of the difficult-to-dissolve special medical food powder for reducing hypertension, hyperlipidemia and hyperglycemia is improved, and the medicinal effect after medical eating is greatly improved.

Description

Preparation method and preparation device of insoluble special medical food powder for reducing high blood pressure, high blood sugar and high blood sugar
Technical Field
The invention relates to the technical field of solid powder, in particular to a preparation method and a preparation device of insoluble special medical food powder for reducing high blood pressure, high blood sugar and high blood sugar.
Background
After a drug is administered orally, the active ingredient of the drug must first be dissolved and then absorbed through the gastrointestinal mucosa into the systemic circulation. When it comes to the rate and extent of absorption of the active pharmaceutical ingredient in the sustained release formulation in vivo, the BCS system primarily considers three key factors, namely: solubility, dissolution, and permeability of the gastrointestinal tract. Among them, the solubility of the drug directly affects the absorption and bioavailability of the drug in the body. About 40% of the commercially available drugs are poorly soluble drugs, and for some drugs with strong activity and poor solubility, appropriate formulations and processes are generally designed through various technologies so that the dissolution and absorption of active ingredients meet clinical requirements.
In the preparation process of the formulation, a suitable dosage form is generally selected depending on the dissolution characteristics and permeability of the active ingredient. The powder is a preparation with maximum dispersion degree in a solid dosage form, and has small particle size and large specific surface area. Compared with other solid dosage forms, the powder has the advantages of easy dispersion, quick dissolution, quick absorption, and quick action. The powder can be directly used as a dosage form, and is also an intermediate for preparing other dosage forms such as granules, capsules, tablets, suspensions, aerosols, powders, sprays and the like. Therefore, the preparation technology and requirements of the powder have common significance in other dosage forms. Powders are generally prepared by comminuting, sieving, mixing, dosing, packaging and storing. Through crushing, the granularity of the solid medicine can be greatly reduced, the components can be uniformly mixed, and the dissolution rate of the insoluble medicine can be improved. The pulverization operation also affects the quality and drug efficacy of the pharmaceutical preparation, and sufficient attention should be paid. At present, the commonly used pulverization methods are mainly a grinding method, an impact pulverization method, a jet milling method, a wet high-pressure homogenization method, and the like. The quality control of the powder is realized by selecting different crushing methods, crushing processes and devices, and the method has important practical significance.
Disclosure of Invention
Aiming at the technical problems in the related art, the invention provides a preparation method and a preparation device of insoluble special medical food powder for reducing hypertension, hyperglycemia and hyperlipidemia.
In order to achieve the technical purpose, the technical scheme of the invention is designed as follows:
on one hand, the invention provides a preparation method of insoluble special medical food powder for reducing high blood pressure, high blood sugar and high blood sugar, which comprises the following specific steps:
1) the insoluble material and a solubilizing solvent are subjected to ultrasonic dispersion and mixing in an insoluble material ultrasonic microsphere preparation unit to prepare solubilizing microspheres;
2) under the action of the air pressure of an inert gas pressure device, the solubilizing microspheres are sprayed out through a heating spray head and dried in a closed drying chamber at constant temperature to form mixed gas containing solid particles;
3) the mixed gas containing solid particles enters a size regulating cyclone separation unit for solid-vapor separation under the action of pressure, and the solid particles fall into a collector under the control of an angle regulating cyclone baffle to obtain solid powder; the gas is treated by a vacuum pump and condensed reflux and a vacuum system unit to recover the solubilization solvent, and the solubilization solvent returns to the solubilization solvent preparation unit under the action of the vacuum pump.
Further, the solubilizing solvent comprises one or more of ethanol, acetone, carbon tetrachloride and propylene glycol.
Further, the insoluble material comprises one or more of tea polyphenol, corn linoleic acid, nicotinic acid, rutin, soybean phytosterol, phaseolin, mung bean polysaccharide, oat fiber and B vitamins.
On the other hand, the invention provides a preparation device of insoluble three-high special medical food powder, which comprises a solubilizing solvent preparation unit, an insoluble material ultrasonic microsphere preparation unit, a vacuum constant-temperature spray drying unit, a size regulation cyclone separation unit and a condensation reflux and vacuum system unit;
wherein the liquid outlet of the solubilizing solvent preparation unit is communicated with the liquid inlet of the ultrasonic chamber of the insoluble material ultrasonic microsphere preparation unit;
a discharge hole of the insoluble material ultrasonic microsphere preparation unit is communicated with a heating spray head of the vacuum constant-temperature spray drying unit;
a discharge port of a drying chamber of the vacuum constant-temperature spray drying unit is communicated with an air inlet of the size-regulating cyclone separation unit;
the air outlet of the size-regulating cyclone separation unit is communicated with the air inlet of the condensation reflux and vacuum system unit;
the reflux pipeline of the condensation reflux and vacuum system unit is communicated with the solvent buffer chamber of the solubilization solvent preparation unit to form a closed preparation device;
an air inlet of the vacuum constant-temperature spray drying unit is communicated with an inert gas pressure device;
and the condensing reflux and the air outlet of the vacuum system unit are communicated with a vacuum pump.
Further, the solubilization solvent preparation unit comprises a solvent buffer chamber, a liquid outlet and a liquid inlet which are arranged on the solvent buffer chamber, a liquid outlet speed-control delivery pump and a liquid outlet valve which are communicated with the liquid outlet, wherein the liquid outlet, the liquid outlet speed-control delivery pump and the liquid outlet valve are communicated through pipelines.
Further, the speed control range of the liquid outlet speed control conveying pump is 0-50L/h.
Further, the insoluble material ultrasonic microsphere preparation unit comprises an ultrasonic chamber, a heating plate, an ultrasonic head, an ultrasonic controller, a feeding hopper, a feeding speed control valve, a discharging port, a discharging speed control delivery pump and a discharging port valve;
the heating plate is arranged at the bottom of the ultrasonic chamber;
the ultrasonic head is communicated with the ultrasonic controller and is arranged in the ultrasonic chamber;
the feeding speed control valve is used for controlling the feeding speed of the feeding hopper;
the discharge port, the discharge speed-control delivery pump and the discharge port valve are communicated through a pipeline.
Further, the ultrasonic controller controls the ultrasonic intensity to be 10-100 Hz.
Further, the temperature of the heating plate is controlled to be 20-50 ℃.
Further, the speed of the discharging speed-control delivery pump is controlled to be 0-50L/h.
Furthermore, the vacuum constant-temperature spray drying unit comprises a heating spray head, an inert gas pressure device, a drying chamber, a constant-temperature electric heating plate, a temperature probe and an intelligent temperature controller;
the inert gas pressure device is communicated with the gas inlet of the heating spray head, and the material entering the heating spray head is sprayed out in a spraying mode through gas pressure;
the feed inlet of the heating spray head is communicated with the discharge outlet of the insoluble material ultrasonic microsphere preparation unit;
the nozzle of the heating nozzle is arranged in the drying chamber, so that the material sprayed by the heating nozzle is sprayed in the drying chamber;
the constant-temperature electric heating plates are arranged on the periphery of the drying chamber and used for adjusting the temperature in the drying chamber;
the temperature probe is arranged in the drying chamber and used for detecting the temperature in the drying chamber;
the intelligent temperature controller is communicated with the temperature probe and the constant-temperature heating plate, and the working condition of the constant-temperature heating plate is controlled through the temperature condition fed back by the temperature probe so as to control the temperature in the drying chamber.
Furthermore, the size-regulating cyclone separation unit comprises an air inlet, a cyclone separation chamber, an angle-regulating cyclone baffle, a collector and an air outlet;
the angle regulation cyclone baffle comprises a plate body, a rocker arm and a rotating mechanism; the plate body and the side wall of the cyclone separation chamber form an angle and are arranged in the cyclone separation chamber; one end of the rocker arm is fixedly contacted with the upper part of the plate body, the other end of the rocker arm penetrates through the side wall of the cyclone separation chamber and extends out of the side wall, and the plate body is adjusted and driven to change the included angle between the plate body and the side wall of the cyclone separation chamber by setting the position between the rotating mechanism and the rocker arm; the rotating mechanism is arranged at the junction of the rocker arm and the side wall of the cyclone separation chamber;
the two angle regulation cyclone baffles are oppositely arranged in the cyclone separation chamber, the included angle between the two angle regulation cyclone baffles and the inner side wall of the cyclone separation chamber is 0-60 degrees, the collector is arranged at the lower end of the cyclone separation chamber, and the distance opening between the two angle regulation cyclone baffles, the inlet of the collector and the central line of the air outlet are on the same central shaft.
Further, the rotation mechanism is a pivot or a hinge. The shape of the plate body is matched with the shape of the side wall of the cyclone separation chamber.
Furthermore, a locking mechanism is arranged on the rotating mechanism, and the fixed rocker arm is locked through the locking mechanism.
Further, the condensation reflux and vacuum system unit comprises an air inlet, a vacuumizing air outlet, a vacuumizing valve, a vacuum pump, a condensation heat exchange pipeline, a solution collecting chamber, a reflux pipeline and a reflux pump;
the air inlet and the vacuumizing air outlet are arranged on the upper side of the solvent collecting chamber;
the condensation heat exchange pipeline is arranged in the middle of the solution collecting chamber; the inlet and outlet of the condensation heat exchange pipeline are communicated with a cold source;
the liquid outlet of the solvent collecting chamber is communicated with a return pipeline through a pipeline; the reflux pump is arranged on the reflux pipeline;
the outlet of the reflux pipeline is communicated with the liquid inlet of the solubilization solvent preparation unit;
and the vacuumizing air outlet, the vacuumizing valve and the vacuum pump are communicated through a pipeline.
The process flow and the equipment provided by the invention creatively adopt the ultrasonic microsphere preparation process of the insoluble material on the basis of the traditional solvent solubilizing medicine, creatively integrate the vacuum and constant temperature processes on the basis of spray drying, and due to the fact that the characteristic control of the material is difficult, the size and angle regulating and controlling device is creatively added by improving the cyclone, and the integration of the processes greatly improves the solubility of the insoluble three-high special medical food powder and greatly improves the edible and medicinal effects. In addition, the use of condensation reflux and a closed system avoids environmental pollution, saves energy and post-treatment cost, promotes the medicine preparation technology from the chemical industry perspective, and has higher practicability.
The invention has the beneficial effects that: the invention provides a preparation method and a preparation device of insoluble three-high special medical food powder, wherein the insoluble material is ultrasonically prepared into microspheres, the particle size is controlled by spraying, and then the vacuum constant-temperature drying is combined, so that the particle size of the material is ensured, the solubility of the insoluble three-high special medical food powder is improved, and the medicinal effect after medical food is greatly improved; by regulating and controlling the size separation of the materials, the powder meeting the standard is obtained, and meanwhile, the solubilizing solvent can be recovered, so that low-consumption production is realized.
By drying the inert gas in a vacuum constant temperature manner, the problems of material deterioration and the like caused by over-high temperature drying are avoided, and the quality of the material is ensured; through material size separation, part of materials in the product have an amorphous state and an excellent dissolution effect, the powder can be completely dissolved in water within 0.5-2 min, and the dissolution amount of the raw material medicines in the same state is lower than 35-43%; the particle size of the obtained powder particles can reach 20-150 nm, the average particle size is 100nm, the particle size distribution range is narrow, the average particle size is unchanged after the powder particles are placed at room temperature for one month, and good stability is shown; the material separation efficiency is efficiently regulated and controlled by regulating and controlling the size between the cyclone baffles during solid-gas separation in the mixed separation gas.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a schematic diagram of the apparatus of the present invention;
fig. 2 is a schematic structural view of the angle-adjustable cyclone baffle.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments that can be derived by one of ordinary skill in the art from the embodiments given herein are intended to be within the scope of the present invention.
Unless otherwise defined, all terms of art used hereinafter have the same meaning as commonly understood by one of ordinary skill in the art. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to limit the scope of the present invention.
Unless otherwise specified, the reagents and materials used in the present invention are commercially available products or products obtained by a known method.
Example 1
The invention provides a preparation device of insoluble three-high-reducing special medical food powder, which comprises a solubilizing solvent preparation unit 1, an insoluble material ultrasonic microsphere preparation unit 2, a vacuum constant-temperature spray drying unit 3, a size regulation cyclone separation unit 4 and a condensation reflux and vacuum system unit 5;
wherein the liquid outlet 12 of the solubilizing solvent preparation unit 1 is communicated with the liquid inlet of the ultrasonic chamber of the insoluble material ultrasonic microsphere preparation unit 3; the solubilization solvent preparation unit 1 comprises a solvent buffer chamber 11, a liquid outlet 12 and a liquid inlet which are arranged on the solvent buffer chamber 11, a liquid outlet speed-control conveying pump 13 and a liquid outlet valve 14 which are communicated with the liquid outlet 12, wherein the liquid outlet 12, the liquid outlet speed-control conveying pump 13 and the liquid outlet valve 14 are communicated through pipelines; the speed control range of the liquid outlet speed control conveying pump 13 is 0-50L/h;
the insoluble material ultrasonic microsphere preparation unit 2 comprises an ultrasonic chamber 21, a heating plate 22, an ultrasonic head 23, an ultrasonic controller 24, a feeding hopper 25, a feeding speed control valve 26, a discharge port 27, a discharge speed control delivery pump 28 and a discharge port valve 29;
the heating plate 22 is arranged at the bottom of the ultrasonic chamber 21;
the ultrasonic head 23 is communicated with an ultrasonic controller 24 and is arranged in the ultrasonic chamber 21;
the feeding speed control valve 26 is used for controlling the feeding speed of the feeding hopper 25;
the discharge port 27, the discharge speed-control delivery pump 28 and the discharge port valve 29 are communicated through a pipeline;
the ultrasonic controller 24 controls the ultrasonic intensity to be 10-100 Hz;
the temperature of the heating plate 22 is controlled to be 20-50 ℃;
the speed of the discharging speed-controlling delivery pump 28 is controlled to be 0-50L/h;
the ultrasonic microsphere preparation unit 2 for the difficult-to-dissolve materials is used for preparing the ultrasonic microspheres for the difficult-to-dissolve materials, the ultrasonic microspheres are uniformly mixed, the uniformity of the materials is guaranteed, and the solubility of the materials is improved;
the discharge hole of the insoluble material ultrasonic microsphere preparation unit 2 is communicated with the heating spray head 31 of the vacuum constant-temperature spray drying unit 3;
a discharge port of a drying chamber 33 of the vacuum constant-temperature spray drying unit 3 is communicated with an air inlet of a size-regulating cyclone separation unit 4; the vacuum constant-temperature spray drying unit 3 comprises a heating spray head 31, an inert gas pressure device 32, a drying chamber 33, a constant-temperature electric heating plate 34, a temperature probe 35 and an intelligent temperature controller 36;
the inert gas pressure device 32 is communicated with the gas inlet of the heating spray head 31, and the material entering the heating spray head 31 is sprayed out in a spraying mode through gas pressure; the specific device belongs to the conventional technical field and is not detailed;
the feed inlet of the heating spray head 31 is communicated with the discharge outlet of the insoluble material ultrasonic microsphere preparation unit 2;
the nozzle of the heating nozzle 31 is arranged in the drying chamber 33, so that the material sprayed by the heating nozzle is sprayed in the drying chamber;
the constant-temperature electric heating plates 34 are arranged around the drying chamber 34 and used for adjusting the temperature in the drying chamber;
the temperature probe 35 is arranged in the drying chamber 34 and used for detecting the temperature in the drying chamber;
the intelligent temperature controller 36 is communicated with the temperature probe 35 and the constant-temperature heating plate 34, and controls the working condition of the constant-temperature heating plate through the temperature condition fed back by the temperature probe so as to control the temperature in the drying chamber;
through the treatment of the vacuum constant-temperature spray drying unit 3, the constant-temperature drying of the materials under the inert gas pressure can be ensured, the quality of the materials is ensured, and meanwhile, the particle size of the particles prepared by spraying is controllable, so that the uniformity is further ensured, the dissolution rate of the medicine is improved, and the dissolution performance of the medicine is improved; in the spraying process, the materials are sprayed out of the spray head under the action of high pressure, and then the solvent in the materials is volatilized to prepare micro/nano microsphere particles, so that the liquid drops have coulomb force with the same charge, the mutual repulsion effectively prevents the agglomeration of the liquid drops, and the liquid drops are easier to disperse under the action of inert gas; under constant temperature, the collected and prepared micro-nano particles and the solvent paper are more conveniently separated;
the air outlet of the size-regulating cyclone separation unit 4 is communicated with the air inlet of the condensation reflux and vacuum system unit 5; the size-regulating cyclone separation unit 4 comprises an air inlet 41, a cyclone separation chamber 42, an angle-regulating cyclone baffle 43, a collector 44 and an air outlet 46;
the angle-adjusting cyclone barrier 43 includes a plate body 431, a rocker arm 432 and a rotating mechanism 45; the plate body 431 is arranged in the cyclone chamber 42 at an angle with the side wall of the cyclone chamber 42; one end of the rocker arm 432 is fixedly contacted with the upper part of the plate body 431, the other end of the rocker arm 432 penetrates through the side wall of the cyclone separation chamber 42 and extends out of the side wall, and the plate body 431 is adjusted and driven to change the included angle between the plate body 431 and the side wall of the cyclone separation chamber 42 by setting the position between the rotating mechanism 45 and the rocker arm 432; the rotation mechanism 45 is arranged at the intersection of the rocker arm 432 and the side wall of the cyclonic chamber;
the two angle-adjusting cyclone baffles 43 are oppositely arranged in the cyclone separation chamber, the included angle between the two angle-adjusting cyclone baffles 43 and the inner side wall of the cyclone separation chamber is 0-60 degrees, the collector 44 is arranged at the lower end of the cyclone separation chamber, and the central line of a spacing opening of the two angle-adjusting cyclone baffles 43, the central line of an inlet of the collector and the central line of an air outlet are on the same central axis;
the rotating mechanism 45 is a pivot or a hinge; the shape of the plate body 451 is matched with that of the sidewall of the cyclone separation chamber;
the rotating mechanism is provided with a locking mechanism 433, and the fixed rocker arm 432 is locked through the locking mechanism 433;
the mixed gas containing solid particles forms a solid-gas fluid circulating flow line under the action of vacuum force, enters a cyclone separation chamber along an air inlet, changes the flow direction under the action of an angle regulation cyclone baffle, and forms anticlockwise cyclone type rapid rotating airflow along the side wall of the cyclone separation chamber, so that solid powder entrained in the airflow is separated under the self gravity, all the solid powder falls into a collector to realize solid gas separation, and the vapor enters a condensation reflux and vacuum system unit through an air outlet, is condensed into solution through a condensation heat exchange pipeline and is collected in a solution collection chamber;
the solid-gas separation is realized through the action of the size regulating cyclone separation unit, so that the separation efficiency is high, the angle of the cyclone baffle plate can be adjusted according to the requirement of an actual product, and the separation efficiency is controlled; through separation, the solvent residue in the medicine is avoided, and the medicine solvent residue can be avoided;
the distance between the cyclone baffles is regulated and controlled by regulating the angle, so that the gas flow is regulated, the gas inlet of the size-regulated cyclone separation unit is ensured to feed gas at the optimal gas flow speed, and the separation effect of the powder is more stable; the powder particles with high density fall into a collector; the low-density gas enters the condensation reflux and vacuum system unit through the air outlet; the impact force of the airflow on the side wall of the cyclone separation chamber can be reduced through the angle cyclone baffle, and meanwhile, the dispersing agent can be better settled; the obtained powder has good monodispersity, high purity and diameter reaching micro/nano scale; the particle size of the obtained powder particles can reach 20-150 nm, and the average particle size is 100 nm;
the reflux pipeline 57 of the condensed reflux and vacuum system unit 5 is communicated with the solvent buffer chamber 11 of the solubilization solvent preparation unit 1 to form a closed preparation device;
an air inlet of the vacuum constant-temperature spray drying unit 4 is communicated with an inert gas pressure device;
the condensing reflux and the air outlet of the vacuum system unit 5 are communicated with a vacuum pump 54;
the condensation reflux and vacuum system unit 5 comprises an air inlet, a vacuumizing air outlet 52, a vacuumizing valve 53, a vacuum pump 54, a condensation heat exchange pipeline 55, a solution collecting chamber 56, a reflux pipeline 57 and a reflux pump 58;
the air inlet and the vacuumizing air outlet 52 are arranged on the upper side of the solvent collecting chamber 11;
the condensing heat exchange pipe 55 is provided in the middle of the solution collecting chamber 56; the inlet and outlet of the condensation heat exchange pipeline 55 are communicated with a cold source;
the liquid outlet of the solvent collection chamber 11 is communicated with a return pipeline 57 through a pipeline; the return pump 58 is arranged on the return pipeline 57;
the outlet of the reflux pipeline 57 is communicated with the liquid inlet of the solubilization solvent preparation unit 1;
the vacuum pumping air outlet 52, the vacuum pumping valve 53 and the vacuum pump 54 are communicated through pipelines. The vacuum pump can be used for vacuumizing in due time according to the working condition of the whole closed system, and the system can be ensured to run reasonably.
Through the effect of condensation backward flow and vacuum system unit, realize the vacuum control to the initial operation of entire system, realize the flow of material in the entire system, moreover can realize retrieving the condensation of solvent steam, reach the purpose of solvent recovery. In the whole closed system, the sterility of the used materials is realized, and the safety of subsequent medication is ensured.
The connection mode which needs to be connected with a power supply and the circuit for controlling the relevant valve, which are not mentioned in the invention, can be realized by the conventional technology, and the detailed description is not needed.
The preparation method of the insoluble special medical food powder for reducing three highs by using the equipment comprises the following specific steps:
before the system is started, the inlets and the outlets are closed, the whole preparation system is under the pressure of-0.1 to-10 MPa under the action of the vacuum pump 54, and the vacuumizing valve 53 and the vacuum pump 54 are closed after the system reaches negative pressure.
In the insoluble material ultrasonic microsphere preparation unit 1, insoluble materials enter an ultrasonic chamber from a feeding hopper 25 under the action of a feeding speed control valve 26, a solubilizing solvent enters the ultrasonic chamber 21 under the action of a liquid outlet speed control delivery pump 12 (the initial solubilizing solvent is directly added into a solvent buffer chamber 11), an ultrasonic controller 24 in the ultrasonic chamber 21 starts an ultrasonic head 23 to work, a heating plate 22 is electrified and controlled to work, and solubilizing microspheres are prepared after ultrasonic dispersion and mixing; the insoluble material comprises one or more of tea polyphenols, corn linoleic acid, nicotinic acid, rutin, soybean phytosterol, mung bean globulin, mung bean polysaccharide, oat fiber and B vitamins; the solubilizing solvent comprises one or more of ethanol, acetone, carbon tetrachloride and propylene glycol;
the solubilizing microspheres enter a heating spray head 31 under the action of a discharge speed-control delivery pump 28; under the action of the air pressure of an inert gas pressure device 32, the solubilizing microspheres are sprayed out through a heating spray head 31 and dried in a closed drying chamber 33 at constant temperature to form mixed gas containing solid particles; through the cooperative work among the inert gas pressure device 32, the constant-temperature electric heating plate 34, the temperature probe 35 and the intelligent temperature controller 36, the vacuum degree in the drying chamber is controlled to be minus 0.1-10MPa, the temperature is 50-200 ℃, and the method is specifically determined according to the property of the insoluble material and the property of the solubilizing solvent;
the mixed gas containing solid particles enters a size regulation cyclone separation unit 4 for solid-vapor separation under the action of the pressure of inert gas sprayed in a drying chamber 33, and the solid particles fall into a collector 44 under the control of an angle regulation cyclone baffle 43 to obtain solid powder (the obtained powder can be completely dissolved in water within 0.5-2 min; the particle size of the obtained powder particles can reach 20-150 nm, and the average particle size is 100 nm); the vapor is acted by a vacuum pump 54 to exchange heat with a condensation heat exchange pipeline 55 in the condensation reflux and vacuum system unit 5 to realize condensation and recover the solubilization solvent, and the solubilization solvent reflux returns to the solubilization solvent preparation unit.
The process flow and the equipment provided by the invention creatively adopt the ultrasonic microsphere preparation process of the insoluble material on the basis of the traditional solvent solubilizing medicine, creatively integrate the vacuum and constant temperature processes on the basis of spray drying, and due to the fact that the characteristic control of the material is difficult, the size and angle regulating and controlling device is creatively added by improving the cyclone, and the integration of the processes greatly improves the solubility of the insoluble three-high special medical food powder and greatly improves the edible and medicinal effects. In addition, the use of condensation reflux and a closed system avoids environmental pollution, saves energy and post-treatment cost, promotes the medicine preparation technology from the chemical industry perspective, and has higher practicability.
Specific example 1
Tea polyphenol and corn linoleic acid enter an ultrasonic chamber from a feeding funnel under the action of a feeding speed control valve according to the mass ratio of 1:2, 98% ethanol with twice volume amount enters the ultrasonic chamber under the action of a liquid outlet speed control delivery pump, an ultrasonic controller in the ultrasonic chamber starts an ultrasonic head to work, a heating plate is electrified to work, the temperature is controlled at 50 ℃, and the materials are uniformly mixed;
the solubilizing microspheres enter a heating spray head under the action of a discharge speed-control delivery pump; under the action of the air pressure of an inert gas pressure device, the solubilizing microspheres are sprayed out through a heating spray head and dried in a closed drying chamber at constant temperature to form mixed gas containing solid particles; controlling the vacuum degree in the drying chamber to be negative 0.5MPa and the temperature to be 50 ℃ by the cooperative work of an inert gas pressure device, a constant-temperature electric heating plate, a temperature probe and an intelligent temperature controller;
the mixed gas containing solid particles enters a size regulation cyclone separation unit for solid-vapor separation under the action of the pressure of inert gas sprayed into a drying chamber, and the solid particles fall into a collector under the control of an angle regulation cyclone baffle to obtain solid powder (the obtained powder can be completely dissolved in water within 1 min; the particle size of the obtained powder particles can reach 20-150 nm, and the average particle size is 100 nm); the vapor is acted by a vacuum pump in the condensation reflux and vacuum system unit to exchange heat with a condensation heat exchange pipeline to realize condensation and recovery of the solubilization solvent, and the solubilization solvent returns to the solubilization solvent preparation unit through reflux.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims (10)

1. A preparation method of insoluble special medical food powder for reducing high blood pressure, high blood sugar and high blood sugar is characterized by comprising the following specific steps:
1) the insoluble material and a solubilizing solvent are subjected to ultrasonic dispersion and mixing in an insoluble material ultrasonic microsphere preparation unit to prepare solubilizing microspheres;
2) under the action of the air pressure of an inert gas pressure device, the solubilizing microspheres are sprayed out through a heating spray head and dried in a closed drying chamber at constant temperature to form mixed gas containing solid particles;
3) the mixed gas containing solid particles enters a size regulating cyclone separation unit for solid-vapor separation under the action of pressure, and the solid particles fall into a collector under the control of an angle regulating cyclone baffle to obtain solid powder; the gas is treated by a vacuum pump and condensed reflux and a vacuum system unit to recover the solubilization solvent, and the solubilization solvent returns to the solubilization solvent preparation unit under the action of the vacuum pump.
2. The process for preparing a sparingly soluble medical powder for reducing hypertension, hyperglycemia and hyperlipidemia according to claim 1, wherein the solubilizing solvent comprises one or more of ethanol, acetone, carbon tetrachloride and propylene glycol.
3. The method for preparing the insoluble powder for reducing high blood pressure, high blood sugar and high blood sugar as claimed in claim 1, wherein the insoluble material comprises one or more of tea polyphenol, corn linoleic acid, nicotinic acid, rutin, soybean phytosterol, phaseolin, mung bean polysaccharide, oat fiber and B vitamins.
4. A preparation device for the slightly soluble three-high special medical food powder for realizing the method of any one of claims 1 to 3 is characterized by comprising a solubilizing solvent preparation unit, a slightly soluble material ultrasonic microsphere preparation unit, a vacuum constant-temperature spray drying unit, a size regulation cyclone separation unit, a condensation reflux and vacuum system unit;
wherein the liquid outlet of the solubilizing solvent preparation unit is communicated with the liquid inlet of the ultrasonic chamber of the insoluble material ultrasonic microsphere preparation unit;
a discharge hole of the insoluble material ultrasonic microsphere preparation unit is communicated with a heating spray head of the vacuum constant-temperature spray drying unit;
a discharge port of a drying chamber of the vacuum constant-temperature spray drying unit is communicated with an air inlet of the size-regulating cyclone separation unit;
the air outlet of the size-regulating cyclone separation unit is communicated with the air inlet of the condensation reflux and vacuum system unit;
the reflux pipeline of the condensation reflux and vacuum system unit is communicated with the solvent buffer chamber of the solubilization solvent preparation unit to form a closed preparation device;
an air inlet of the vacuum constant-temperature spray drying unit is communicated with an inert gas pressure device;
and the condensing reflux and the air outlet of the vacuum system unit are communicated with a vacuum pump.
5. The apparatus for preparing a difficult-to-dissolve three-high medical powder as claimed in claim 4, wherein the solubilizing solvent preparation unit comprises a solvent buffer chamber, a liquid outlet and a liquid inlet disposed above the solvent buffer chamber, a liquid outlet speed-controlling delivery pump connected to the liquid outlet, and a liquid outlet valve, wherein the liquid outlet, the liquid outlet speed-controlling delivery pump and the liquid outlet valve are connected to each other via pipes.
6. The device for preparing the slightly soluble special medical food powder for reducing hyperlipidemia, hypertension and hyperglycemia as claimed in claim 4, wherein the slightly soluble material ultrasonic microsphere preparation unit comprises an ultrasonic chamber, a heating plate, an ultrasonic head, an ultrasonic controller, a feeding funnel, a feeding speed control valve, a discharging port, a discharging speed control delivery pump and a discharging port valve;
the heating plate is arranged at the bottom of the ultrasonic chamber;
the ultrasonic head is communicated with the ultrasonic controller and is arranged in the ultrasonic chamber;
the feeding speed control valve is used for controlling the feeding speed of the feeding hopper;
the discharge port, the discharge speed-control delivery pump and the discharge port valve are communicated through a pipeline.
7. The device for preparing the slightly soluble special medical food powder for reducing hypertension, hyperglycemia and hyperlipidemia as claimed in claim 4, wherein the vacuum constant-temperature spray drying unit comprises a heating spray head, an inert gas pressure device, a drying chamber, a constant-temperature electric heating plate, a temperature probe and an intelligent temperature controller;
the inert gas pressure device is communicated with the gas inlet of the heating spray head, and the material entering the heating spray head is sprayed out in a spraying mode through gas pressure;
the feed inlet of the heating spray head is communicated with the discharge outlet of the insoluble material ultrasonic microsphere preparation unit;
the nozzle of the heating nozzle is arranged in the drying chamber, so that the material sprayed by the heating nozzle is sprayed in the drying chamber;
the constant-temperature electric heating plates are arranged on the periphery of the drying chamber and used for adjusting the temperature in the drying chamber;
the temperature probe is arranged in the drying chamber and used for detecting the temperature in the drying chamber;
the intelligent temperature controller is communicated with the temperature probe and the constant-temperature heating plate, and the working condition of the constant-temperature heating plate is controlled through the temperature condition fed back by the temperature probe so as to control the temperature in the drying chamber.
8. The device for preparing insoluble special medical and food powder for reducing hyperlipidemia, hypertension and hyperglycemia as claimed in claim 4, wherein the size-regulating cyclone separation unit comprises an air inlet, a cyclone separation chamber, an angle-regulating cyclone baffle, a collector, and an air outlet;
the angle regulation cyclone baffle comprises a plate body, a rocker arm and a rotating mechanism; the plate body and the side wall of the cyclone separation chamber form an angle and are arranged in the cyclone separation chamber; one end of the rocker arm is fixedly contacted with the upper part of the plate body, the other end of the rocker arm penetrates through the side wall of the cyclone separation chamber and extends out of the side wall, and the plate body is adjusted and driven to change the included angle between the plate body and the side wall of the cyclone separation chamber by setting the position between the rotating mechanism and the rocker arm; the rotating mechanism is arranged at the junction of the rocker arm and the side wall of the cyclone separation chamber;
the two angle regulation cyclone baffles are oppositely arranged in the cyclone separation chamber, the included angle between the two angle regulation cyclone baffles and the inner side wall of the cyclone separation chamber is 0-60 degrees, the collector is arranged at the lower end of the cyclone separation chamber, and the distance opening between the two angle regulation cyclone baffles, the inlet of the collector and the central line of the air outlet are on the same central shaft.
9. The device for preparing insoluble special medical food powder for reducing hyperlipidemia, hyperglycemia and hyperglycemia as claimed in claim 8, wherein the rotating mechanism is a pivot or a hinge; the shape of the plate body is matched with that of the side wall of the cyclone separation chamber;
and the rotating mechanism is provided with a locking mechanism, and the fixed rocker arm is locked through the locking mechanism.
10. The apparatus for preparing insoluble special medical food powder for reducing hyperlipidemia, hyperglycemia and hyperglycemia as claimed in claim 4, wherein the condensed reflux and vacuum system unit comprises an air inlet, a vacuum outlet, a vacuum valve, a vacuum pump, a condensed heat exchange pipeline, a solution collection chamber, a reflux pipeline and a reflux pump;
the air inlet and the vacuumizing air outlet are arranged on the upper side of the solvent collecting chamber;
the condensation heat exchange pipeline is arranged in the middle of the solution collecting chamber; the inlet and outlet of the condensation heat exchange pipeline are communicated with a cold source;
the liquid outlet of the solvent collecting chamber is communicated with a return pipeline through a pipeline; the reflux pump is arranged on the reflux pipeline;
the outlet of the reflux pipeline is communicated with the liquid inlet of the solubilization solvent preparation unit;
and the vacuumizing air outlet, the vacuumizing valve and the vacuum pump are communicated through a pipeline.
CN202010063192.6A 2020-01-20 2020-01-20 Preparation method and preparation device of insoluble special medical food powder for reducing high blood pressure, high blood sugar and high blood sugar Pending CN111249236A (en)

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Application publication date: 20200609