CN111247596A - 组织学图像的自动化图案识别和评分方法 - Google Patents

组织学图像的自动化图案识别和评分方法 Download PDF

Info

Publication number
CN111247596A
CN111247596A CN201880068174.8A CN201880068174A CN111247596A CN 111247596 A CN111247596 A CN 111247596A CN 201880068174 A CN201880068174 A CN 201880068174A CN 111247596 A CN111247596 A CN 111247596A
Authority
CN
China
Prior art keywords
fibrosis
liver
score
steatosis
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880068174.8A
Other languages
English (en)
Chinese (zh)
Inventor
约翰·布罗泽克
娜塔莉·德加莱克斯
伯诺伊特·诺埃尔
埃尔顿·雷克斯帕杰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genfit SA
Original Assignee
Genfit SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genfit SA filed Critical Genfit SA
Publication of CN111247596A publication Critical patent/CN111247596A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/02Instruments for taking cell samples or for biopsy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/42Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222Evaluating particular parts, e.g. particular organs
    • A61B5/4244Evaluating particular parts, e.g. particular organs liver
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7264Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271Specific aspects of physiological measurement analysis
    • A61B5/7278Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • G06N3/0464Convolutional networks [CNN, ConvNet]
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods
    • G06N3/09Supervised learning
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/40ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/20ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/40ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10056Microscopic image
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20081Training; Learning
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30024Cell structures in vitro; Tissue sections in vitro
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30056Liver; Hepatic

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Data Mining & Analysis (AREA)
  • Pathology (AREA)
  • Theoretical Computer Science (AREA)
  • Molecular Biology (AREA)
  • Databases & Information Systems (AREA)
  • General Physics & Mathematics (AREA)
  • Artificial Intelligence (AREA)
  • Biophysics (AREA)
  • Mathematical Physics (AREA)
  • Evolutionary Computation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Computing Systems (AREA)
  • Veterinary Medicine (AREA)
  • Software Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • Computational Linguistics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physiology (AREA)
  • Immunology (AREA)
  • Quality & Reliability (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Signal Processing (AREA)
CN201880068174.8A 2017-10-20 2018-10-19 组织学图像的自动化图案识别和评分方法 Pending CN111247596A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17197623 2017-10-20
EP17197623.6 2017-10-20
EP18166425 2018-04-09
EP18166425.1 2018-04-09
PCT/EP2018/078711 WO2019077108A2 (en) 2017-10-20 2018-10-19 AUTOMATED METHOD OF ASSESSING AND RECOGNIZING PROFILES ON HISTOLOGICAL IMAGES

Publications (1)

Publication Number Publication Date
CN111247596A true CN111247596A (zh) 2020-06-05

Family

ID=63862171

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880068174.8A Pending CN111247596A (zh) 2017-10-20 2018-10-19 组织学图像的自动化图案识别和评分方法

Country Status (9)

Country Link
US (1) US11676269B2 (https=)
EP (1) EP3698377A2 (https=)
JP (1) JP7293243B2 (https=)
KR (1) KR20200090757A (https=)
CN (1) CN111247596A (https=)
AU (1) AU2018351635A1 (https=)
CA (1) CA3078672A1 (https=)
MX (1) MX2020003990A (https=)
WO (1) WO2019077108A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112233811A (zh) * 2020-10-19 2021-01-15 江苏珂玛麒生物科技有限公司 一种nash肝脏数字病理分析系统、工作方法、应用
CN113469939A (zh) * 2021-05-26 2021-10-01 透彻影像(北京)科技有限公司 一种基于特性曲线的her-2免疫组化自动判读系统
CN115439701A (zh) * 2022-11-07 2022-12-06 中国医学科学院北京协和医院 多模态超声图像的ra活动度深度学习方法及装置
CN116563206A (zh) * 2023-03-10 2023-08-08 复旦大学 肝脏病理切片图像的肝小叶炎症检测和定量装置和方法

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020027732A1 (en) * 2018-07-30 2020-02-06 Agency For Science, Technology And Research Method and system for assessing fibrosis in a tissue sample
BR112022001446A2 (pt) 2019-07-26 2022-07-12 Univ Leland Stanford Junior Sistemas e métodos para analisar, detectar e tratar formação de rede de tecido conjuntivo fibrótico
KR102938955B1 (ko) * 2019-09-11 2026-03-12 삼성전자주식회사 영상 인식 모델을 학습하는 전자 장치 및 그 동작 방법
US11527319B1 (en) * 2019-09-13 2022-12-13 PathAI, Inc. Systems and methods for frame-based validation
WO2021141537A1 (en) * 2020-01-08 2021-07-15 Histoindex Pte Ltd Method and system for evaluating efficacy of a therapeutic intervention
WO2021191509A1 (fr) 2020-03-24 2021-09-30 Biocellvia Système et procédé pour produire un indicateur à partir d'une image d'une coupe histologique
CN112200763B (zh) * 2020-08-24 2024-08-06 江苏科技大学 一种基于肝脏ct影像的肝功能分级方法
US11798165B2 (en) 2020-10-28 2023-10-24 Sony Group Corporation Tumor detection and segmentation for DPI AI platform routes
WO2022101853A1 (en) * 2020-11-16 2022-05-19 Novartis Ag Method of determining liver fibrosis
US11651496B2 (en) * 2021-03-11 2023-05-16 Ping An Technology (Shenzhen) Co., Ltd. Liver fibrosis recognition method based on medical images and computing device using thereof
WO2022191781A1 (en) * 2021-03-12 2022-09-15 Histoindex Pte Ltd Method and system for assessing nonalcoholic steatohepatitis
WO2022197917A1 (en) * 2021-03-18 2022-09-22 Leica Biosystems Imaging, Inc. Apparatus and method for training of machine learning models using annotated image data for pathology imaging
JP7699227B2 (ja) * 2021-05-21 2025-06-26 ヴェンタナ メディカル システムズ, インク. 病理組織画像におけるアーチファクトの自動セグメンテーション
US12231802B2 (en) 2021-08-04 2025-02-18 Theia Scientific, LLC System and method for multi-modal microscopy
KR102755028B1 (ko) * 2021-10-12 2025-01-21 주식회사 유케어트론 측정스펙트럼 분석장치 및 분석방법
WO2023086032A2 (en) * 2021-11-11 2023-05-19 Histoindex Pte Ltd Method and system for assessing nash cirrhosis
CN114550942B (zh) * 2022-02-16 2023-06-30 四川大学华西医院 一种肝脏显著纤维化预测模型及构建方法
AU2023225716A1 (en) * 2022-02-24 2024-09-12 Vinay Pulim System and method for annotating pathology images to predict patient outcome
WO2023204768A1 (en) * 2022-04-21 2023-10-26 Histoindex Pte Ltd Method and system for evaluating a therapeutic intervention
CN115565698B (zh) * 2022-10-26 2024-03-29 南方医科大学珠江医院 一种人工智能评估供肾质量的方法及系统
CN119181455A (zh) * 2023-06-21 2024-12-24 赫斯托因德私人有限公司 用于预测代谢功能障碍相关联脂肪变性肝病的临床结果的方法和系统
CN116682109B (zh) * 2023-08-02 2023-11-17 深圳金质科技有限公司 一种病理显微图像的分析方法、装置、设备及存储介质
US12533394B2 (en) 2023-11-15 2026-01-27 Glycomantra Inc. Compositions and methods for treating metabolic disorders
GB2631590A (en) * 2024-06-17 2025-01-08 Histoindex Pte Ltd Method and system for predicting a clinical outcome of metabolic dysfunction-associated steatotic liver disease
CN118657792B (zh) * 2024-08-21 2025-01-14 南方医科大学南方医院 基于he图像的肝细胞癌病理组学分析方法、设备和介质
CN118782237B (zh) * 2024-09-13 2025-02-18 佛山复星禅诚医院有限公司 基于人工智能评估非酒精性脂肪肝模型的系统
CN121033844B (zh) * 2025-08-20 2026-03-24 上海市浦东医院(复旦大学附属浦东医院) 一种实验染色结果图像处理计算方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103164599A (zh) * 2011-12-10 2013-06-19 西安百利信息科技有限公司 基于腹部ct图像传输的肝硬化远程会诊系统
WO2013189822A1 (en) * 2012-06-21 2013-12-27 Luric Datenbank Gbr Methods for determining the risk of mortality in patients with cardiovascular disease
US20150339816A1 (en) * 2013-01-08 2015-11-26 Agency For Science, Technology And Research A method and system for assessing fibrosis in a tissue
CN105228508A (zh) * 2013-03-08 2016-01-06 新加坡健康服务有限公司 一种测定用于分类的危险评分的系统和方法
US20170032090A1 (en) * 2015-07-30 2017-02-02 Siemens Medical Solutions Usa, Inc. Virtual biopsy techniques for analyzing diseases
US20170261584A1 (en) * 2014-09-01 2017-09-14 bioProtonics, LLC Selective sampling for assessing structural spatial frequencies with specific contrast mechanisms

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2201518A4 (en) * 2007-09-21 2011-12-21 Aperio Technologies Inc IMPROVED IMAGE QUALITY FOR DIGITAL DIAGNOSTIC RESOLUTION DIGITAL PICTURE PICTURES
JP5771513B2 (ja) * 2011-11-24 2015-09-02 学校法人慶應義塾 病理診断支援装置、病理診断支援方法、及び病理診断支援プログラム
JP6763305B2 (ja) * 2014-12-09 2020-09-30 コニカミノルタ株式会社 画像処理装置及び画像処理プログラム
JP6170994B2 (ja) * 2015-12-22 2017-07-26 株式会社フジミインコーポレーテッド 粉末積層造形に用いるための造形用材料

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103164599A (zh) * 2011-12-10 2013-06-19 西安百利信息科技有限公司 基于腹部ct图像传输的肝硬化远程会诊系统
WO2013189822A1 (en) * 2012-06-21 2013-12-27 Luric Datenbank Gbr Methods for determining the risk of mortality in patients with cardiovascular disease
US20150339816A1 (en) * 2013-01-08 2015-11-26 Agency For Science, Technology And Research A method and system for assessing fibrosis in a tissue
CN105228508A (zh) * 2013-03-08 2016-01-06 新加坡健康服务有限公司 一种测定用于分类的危险评分的系统和方法
US20170261584A1 (en) * 2014-09-01 2017-09-14 bioProtonics, LLC Selective sampling for assessing structural spatial frequencies with specific contrast mechanisms
US20170032090A1 (en) * 2015-07-30 2017-02-02 Siemens Medical Solutions Usa, Inc. Virtual biopsy techniques for analyzing diseases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ABDUL M. OSEINI ET AL: "Therapies in non-alcoholic steatohepatitis (NASH)" *
ALEXANDER ALIPER ET AL: "Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data" *
FERNANDO BRIL ET AL: "Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes: A Call to Action" *
GOCERI EVGIN ET AL: "Quantification of liver fat: A comprehensive review" *
MENG DAN ET AL: "Liver Fibrosis Classification Based on Transfer Learning and FCNet for Ultrasound Images" *
YASAKA KOICHIRO ET AL: "Liver Fibrosis: Deep Convolutional Neural Network for Staging by Using Gadoxetic Acid-enhanced Hepatobiliary Phase MR Images" *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112233811A (zh) * 2020-10-19 2021-01-15 江苏珂玛麒生物科技有限公司 一种nash肝脏数字病理分析系统、工作方法、应用
CN113469939A (zh) * 2021-05-26 2021-10-01 透彻影像(北京)科技有限公司 一种基于特性曲线的her-2免疫组化自动判读系统
CN113469939B (zh) * 2021-05-26 2022-05-03 透彻影像(北京)科技有限公司 一种基于特性曲线的her-2免疫组化自动判读系统
CN115439701A (zh) * 2022-11-07 2022-12-06 中国医学科学院北京协和医院 多模态超声图像的ra活动度深度学习方法及装置
CN116563206A (zh) * 2023-03-10 2023-08-08 复旦大学 肝脏病理切片图像的肝小叶炎症检测和定量装置和方法
CN116563206B (zh) * 2023-03-10 2025-04-01 复旦大学 肝脏病理切片图像的肝小叶炎症检测和定量装置和方法

Also Published As

Publication number Publication date
US20210192722A1 (en) 2021-06-24
US11676269B2 (en) 2023-06-13
MX2020003990A (es) 2020-08-13
KR20200090757A (ko) 2020-07-29
CA3078672A1 (en) 2019-04-25
WO2019077108A2 (en) 2019-04-25
AU2018351635A1 (en) 2020-05-07
JP2021500691A (ja) 2021-01-07
JP7293243B2 (ja) 2023-06-19
WO2019077108A3 (en) 2019-06-20
EP3698377A2 (en) 2020-08-26

Similar Documents

Publication Publication Date Title
CN111247596A (zh) 组织学图像的自动化图案识别和评分方法
EP3956813B1 (en) Detection, prediction, and classification for ocular disease
Xu et al. Colorectal cancer detection based on deep learning
Sirinukunwattana et al. Gland segmentation in colon histology images: The glas challenge contest
US20250046069A1 (en) Label-free virtual immunohistochemical staining of tissue using deep learning
US20250022128A1 (en) Artificial intelligence-based methods for grading, segmenting, and/or analyzing lung adenocarcinoma pathology slides
Avadhani et al. Cytologic predictors of malignancy in bile duct brushings: a multi-reviewer analysis of 60 cases
US11798163B2 (en) Systems and methods for quantitative phenotyping of fibrosis
JP2021525361A (ja) 空間マルチパラメータ細胞亜細胞画像データからの癌再発の予測
Jepsen et al. Digital image analysis of pan-cytokeratin stained tumor slides for evaluation of tumor budding in pT1/pT2 colorectal cancer: Results of a feasibility study
Phillips et al. Segmentation of prognostic tissue structures in cutaneous melanoma using whole slide images
Damkliang et al. Binary semantic segmentation for detection of prostate adenocarcinoma using an ensemble with attention and residual U-Net architectures
Van Buren et al. Artificial intelligence and deep learning to map immune cell types in inflamed human tissue
Zheng et al. Object detection: A novel AI technology for the diagnosis of hepatocyte ballooning
JP2025517869A (ja) 三次リンパ組織様構造の機械学習識別、分類、及び定量化
CN120303695A (zh) 用于检测三级淋巴结构的系统和方法
Koehler et al. Preoperative Prediction of Subtype and Artificial Intelligence-Driven Endomicroscopy Detection of Advanced Neoplasia in IPMNs
Bonaccorso Marinelli et al. Automated quantification of dopaminergic immunostained neurons in substantia nigra using freely available software
Hermsen Artificial Intelligence-Driven Computational Analysis of Kidney Transplant Tissue
Alfredsson Proteomic analysis of chronically inflamed intestine and disease-related strictures in Crohn’s disease patients
Çelik et al. Determination of Fungiform Papilla Number Using Deep Learning Methods
Yu A machine learning based diagnostic study of chronic liver disease using staining techniques
Lee et al. Artificial intelligence‑based quantitative analysis of hepatic fibrosis in carbon tetrachloride-induced mouse model of metabolic dysfunction-associated steatohepatitis
Doelemeyer et al. Deep Learning–Driven Analysis and Quantification of Histopathological features in a DSS-induced Colitis Mouse Model
Bokhorst Hidden in plain sight. Automatic detection of tumor budding in digital pathology images of colorectal cancer

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200605