CN1112353C - Amino benzene carbon amidine derivative and its use - Google Patents

Amino benzene carbon amidine derivative and its use Download PDF

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CN1112353C
CN1112353C CN 96116360 CN96116360A CN1112353C CN 1112353 C CN1112353 C CN 1112353C CN 96116360 CN96116360 CN 96116360 CN 96116360 A CN96116360 A CN 96116360A CN 1112353 C CN1112353 C CN 1112353C
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low alkyl
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姚润华
陈耀清
任海南
成宝珠
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INST OF PARASITIC DISEASES CHI
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Abstract

The present invention relates to aminobenzene amidine derivants shown as the specification. In the formula, Y represents-CONH or CH=N or N=N; R represents C1 to C5 lower alkyl or halogenated C1 to C5 lower alkyl; (CH2)<n>n-***n=0.1; X represents H, C1 to C5 lower alkyl, C1 to C5 lower alkoxyl, nitryl and halide radicals; R1, R2 and R3 are identical or different C1 to C5 lower alkyl. The present invention also relates to the preparation of the compounds and anthelmintic action thereof.

Description

Amino benzene carbon amidine derivative and purposes
The present invention relates to organic synthesis and more specifically relate to the synthetic of benzene carbon amidine analog derivative.
The parasite of human body can be divided protozoon and worm, with regard to anti-parasite medicine, in order to kill or to drive away intravital parasite, must very big toxicity be arranged to parasite, then is that toxicity is the smaller the better to host's (as human body).
Zellon, 1-bromine second-naphthols, phenothiazine, bephenine, to one or two isothiocyano benzene etc. because its toxicity is big or weak curative effect has all been eliminated by market, the LEVAMISOLE HCL of still using clinically, pyrantel has anthelminthic effect preferably, Top Form Wormer uses unsatisfactory clinically, be used for the domestic animal expelling parasite abroad, mebendazole and albendazole class medicine anthelmintic action are stronger, but it can cause the roundworm migration, cause insect to get out or cause acute abdomen such as biliary tract ascarid from patient's mouth or nasal cavity, so the problems such as teratogenesis and this medicine has been positive to Salmonella reversion test are the left alone without help usefulness of the country that has.60-70 was almost monopolized by benzimidazolyl class medicine in domestic and international insect repellent market since the age.Yet the many tools of benzimidazolyl class poison is paid effect, and much such medicine has mutagenesis or teratogenesis even the potential carcinogenic danger arranged so eliminated gradually.Scientists has been carried out big quantity research to seeking novel non-benzimidazolyl class medicine at present, WOllWeber in 1971 etc. have synthesized first phenalgin amidine and animal have been tested and shown that to driving the intravital dog hookworm of dog stenocephaly hookworm, bow roundworm and lion bow roundworm all have preferably fruit.German Patent 2029293 (1971), 2346939 (1975).Because at present used all kinds of insect repellents remain in various shortcoming, it is good that the object of the invention promptly will be sought out a kind of anthelminthic effect clinically, and toxic reaction little, the effective non-benzimidazolyl compounds of rapid, the single agent of effect.
The present invention implements through the following steps: reaction formula
Figure C9611636000061
Y is the CONH base in the formula, or CH=N base or N=N base, and R is C 1-C 5Low alkyl; Halo C 1-C 5Low alkyl;
Figure C9611636000072
N=0,1; X is H; C 1-C 5Low alkyl; C 1-C 5Low-alkoxy; Nitro; Halogen; Hydroxyl; R 1R 2R 3Be C identical or inequality 1-C 5Low alkyl;
When Y was the CONH base, R was C 1-C 5Low alkyl; Halo C 1-C 5Low alkyl; N=0,1; X is a hydrogen; C 1-C 5Low alkyl; C 1-C 5Low-alkoxy; Nitro; Halogen; Hydroxyl; R 1R 2R 3Be C identical or inequality 1-C 5Low alkyl;
When Y was the CH=N base, R was C 1-C 5Low alkyl; N=0,1; X is a hydrogen; Halogen; Hydroxyl; Nitro; C 1-C 5Low-alkoxy; R 1R 2R 3Be C identical or inequality 1-C 5Low alkyl;
When Y was the N=N base, R was a substituted aryl; R 1R 2R 3Be C identical or inequality 1-C 5Low alkyl; And their physiologically acceptable salts.
P-Nitroaniline as starting raw material with
Figure C9611636000075
Compound is in the presence of catalyzer, and catalyzer is PCL 5, POCL 3Temperature of reaction is a refluxing toluene, and a reaction times 3-5 hour condensation obtains N '-(4-nitrophenyl) N, the disubstituted amidine of N-(1).
2. again by compound (I) routine Fe, Sn, SnCO in the presence of appropriate catalyst 2Become amino (II) Deng reductive agent reduction nitro.
3. in suitable organic solvent, react with the aldehyde that replaces by compound (II) and obtain compound (III).
By compound (II) and corresponding acyl chlorides or replace acid anhydrides in anhydrous solvent, react amide compound (IV).
By compound (II) in the presence of hydrochloric acid and water, cool off with Sodium Nitrite make diazonium salt, again with substituted aryl under cooling and stirring, carry out the rare NaOH of coupled reaction neutralize (V).
Table 1Numbering Y R R1    R 2     R 3     A 1.  CONH  
Figure C9611636000082
   CH 3    CH 3   CH 3 2.  CONH  
Figure C9611636000083
            CH 3    CH 3   CH 3   HCl 3.  CONH    BrCH 2-            CH 3    CH 3   CH 3   HBr             CH 3 4.  CONH    BrCH 2-            CH 3    CH 3   CH 3   HBr 5.  CONH           CH 3   CH 3    CH 3   HCl 6.  CONH        CH 3   CH 3    CH 3   HCl 7.  CONH     CH 3   CH 3    HCl 8.  CONH    Cl 2CH-            CH 3   CH 3    CH 3  HCl 9.  CONH             CH 3   CH 3    CH 3   HCl 10. CONH    
Figure C9611636000088
      CH 3   CH 3    CH 3   HCl 11.CONH               CH 3    CH 3    CH 3    HCl 12.CONH               CH 3    CH 3    CH 3    HBr 13.CONH                   CH 3    CH 3    CH 3    HCl 14.-SO 2NH   CH 3                   CH 3    CH 3    CH 3    HCl 15.CH＝N               CH 3    CH 3    CH 3 16.CH＝N    
Figure C9611636000095
          CH 3    CH 3    CH 3 17.CH＝N    
Figure C9611636000096
             CH 3    CH 3    CH 3 18.CH＝N    
Figure C9611636000097
            CH 3    CH 3    CH 3 19.CH＝N       CH 3    CH 3    CH 3 20.CH＝N          CH 3    CH 3    CH 3 21.CH＝N       CH 3    CH 3    CH 3 22.CH＝N       CH 3    CH 3    CH 3 23.S         CH 3    CH 3    CH 3 24.CH＝N  
Figure C9611636000105
  CH 3    CH 3    CH 3 25.CH＝N          CH 3    CH 3    CH 3 26.CH＝N         CH 3    CH 3    CH 3 27.CH＝N           CH 3    CH 3    CH 3 28.CH＝N  
Figure C9611636000109
  CH 3    CH 3    CH 3 29.CH＝N  
Figure C9611636000111
            CH 3    CH 3    CH 3 30.CH＝N     CH 3    CH 3    CH 3 31.CH＝N  
Figure C9611636000113
  CH 3    CH 3    CH 3 32.CH＝N  N-C＝N                 -S       CH 3    CH 3    CH 3 33.CH＝N  
Figure C9611636000114
         CH 3    CH 3    CH 3 34.SO 2 
Figure C9611636000115
          CH 3    CH 3    CH 3 35.CONH  CLCH 2-                          CH 3    CH 3    CH 3   HCl 36.CONH  
Figure C9611636000116
     - CH 3    CH 3    CH 3 37.N＝N                    CH 3    CH 3    CH 3 38.N＝N                     CH 3    CH 3    CH 3
Pharmacological action:
Experimental animal is the SD rat, must triumphant laboratory animal company limited (B, K company) available from the Sino-British joint western pul in Shanghai, and animal production licence number is 47-65,66.Rat body weight is 50～60 grams, and male, female dual-purpose adopts gastric infusion and administered intramuscular, two kinds of approach.
(1) irritate stomach: be subjected to the reagent thing to be made into suspension with 1% tragakanta liquid, gastric infusion of rat mg/kg body weight, the administration capacity is the 1ml/100g body weight.
(2) intramuscular injection: be subjected to the reagent thing to be made into suspension, after ultrasonication, use again with 5% starch fluid.Cut off the hair of shank behind the rat, soup is once injected intramuscular by the mg/kg body weight, injection shot is 0.2～0.3ml/100 body weight.
(3) blank: press that 1ml/100g body weight 1 time is irritated stomach or with an intramuscular injection of 5% starch fluid, 0.2～0.3ml/100g body weight with 1% tragakanta liquid.
Test method:
(1) experimental animal model and worm kind: Brazilian Nippostrongylus---rat model is protected kind so far after being set up by the Chinese Institute of Preventive Medicine institute of parasitic in 1963.
(2) inoculation method: healthy rat is through about 500 of groin subcutaneous vaccination Brazil Nippostrongylus infective stage larva, and the larva suspension of every mouse injection is no more than 0.2ml.Animal was weighed in the inoculation back in 10～11 days, pressed gastric infusion of mg/kg body weight or intramuscular injection.
(3) wash in a pan worm: collect after each mouse administration in 24,48 hours all ight soil respectively, wash precipitator method inspection worm with water.
(4) dissect: rat dissected in 48 hours after the administration, get small intestine (three sections of branchs upper, middle and lower) and residual worm in the intestines is counted with pressed disc method.After large intestine and caecum are cut open, wash precipitator method inspection worm with water.
(5) efficacy assessment: be subjected to reagent thing group, blank and positive drug control group, efficient with following formula calculating expelling parasite, and as the examination efficacy criteria.
Effect observation compound number molecular formula dosage worm reduction rate behind table 2 mouse infection Brazil Nippostrongylus
4 C 13H 19BrN 3O 50mg/kg 61.3％
5 C 17H 19Cl 2N 3O 50mg/kg 52.5％
7 C 17H 18Cl 3N 3O 300mg/kg 0％
50mg/kg 38.6％
8 C 12H 16Cl 3N 3O 75mg/kg 98.6％
15 C 17H 18BrN 3 500mg/kg 61.3％
500mg/kg 100％
16 C 17H 17Cl 2N 3 200mg/kg 100％
25mg/kg 100％
20 C 17H 18ClN 3 15mg/kg 63.8％
25mg/kg 100％
21 C 17H 18ClN 3 15mg/kg 88.3％
22 C 17H 17Cl 2N 3 25mg/kg 100％
29 C 19H 23N 3O 2 25mg/kg 100％
15mg/kg 93.9％
30 C 28H 32N 6 1.5mg/kg 100％
In addition, this compounds has the strong effect of killing to U.S. state hookworm of hamster artificial challenge.The chicken roundworm that chicken is felt naturally, different thorn worm, the fine shape worm of blunt circle, the Rayleigh tapeworm, nodal plate band literary composition tapeworm, Wedging band tapeworm all has 80～100% the effect of killing.Ascaris suum and esophageal orifice worm there are 99～100% the effect of killing, Toxocara canis is had 100% the effect of killing, the dog hookworm is had 97～100% the effect of killing.
Embodiment 1.
The preparation of N '-(4-nitrophenyl) N.N-dimethyl ethanamidine (I):
Take by weighing p-Nitroaniline 41.4g (0.3 mole), N,N-DIMETHYLACETAMIDE 30.5 grams (0.35 mole) and 100 milliliters of toluene place three-necked bottle, under agitation drip phosphorus oxychloride 15.3 grams (0.1 mole) and finish the post-heating backflow 3-5 hour, boil off solvent under the decompression, in the residue impouring frozen water, slowly add the liquid caustic soda of 30% concentration, transfer PH to 8-9, solid is separated out, and filters washing, oven dry, ethyl alcohol recrystallization gets 56g productive rate 90%, fusing point 94-96 ℃.
Embodiment 2.
The preparation of N '-(4-aminophenyl) N.N-dimethyl ethanamidine (II):
Tin protochloride (SnC122H 2O) 90 grams (0.4 mole) are put in the three-necked bottle, add 180 milliliters of concentrated hydrochloric acids, slowly be warming up to 50 ℃, stir down, divide 5 addings with N '-(4-nitrophenyl) N.N-dimethyl ethanamidine of 38.6g (0.2 mole), finish the back, under cooling, splash into 30%NaOH in 40-80 ℃ of insulation 2-5 hour, regulate PH to 10-12 ethyl acetate extraction, anhydrous Na 2SO 4Drying, vinyl acetic monomer is removed in decompression, and recrystallization gets 28.5 grams, productive rate 80% fusing point 92-93 ℃.
Embodiment 3.
N, (compound 30) preparation of N '-two-[4 '-(1-dimethylamino ethylidene amino)] 1,4 one benzene dimethyleneimine:
37.17 N '-(4-aminophenyl) N of gram (0.21 mole), N-dimethyl ethanamidine and terephthalaldehyde 13.1g (0.1 mole) place flask, add 100 milliliters of tetrahydrofuran (THF)s, 40～70 ℃ of temperature of reaction are incubated 4 hours, the reaction postcooling is separated out solid, filter dry 36 grams, the productive rate 80% of getting, the DMF recrystallization, fusing point 225-227 ℃.
Element divides folding: molecular formula: C 28H 32N 6Molecular weight 452.60 calculated values: C:74.34%
H： 7.08％
N:18.58% experimental value: C:74.37%
H： 7.15％
N:18.81% uses with method can make compound 31.
Embodiment 4.
N[4-(1-dimethylamino ethylidene amino) phenyl]-preparation of 2-chloro-phenyl-imines (compound 20):
0.01 mole (II) is dissolved in the 30ml dehydrated alcohol, the 2-phenalgin formaldehyde that adds 0.01 mole, flask heats on water liquid and adds stirring, be warming up to 40～60 ℃, be incubated 4 hours, under reduced pressure boil off ethanol then, stir and add 50ml water down, cooling is placed down and is spent the night, and solid collected by filtration washes drying with water 2 times, gets product (MP 134-136 ℃) with the vinyl acetic monomer recrystallization.
Molecular formula C 17H 18ClN 3Molecular weight 299.5
Element divides the folding calculated value: N=14.02% Cl=11.85%
Experimental value: N=13.95%, Cl=11.98%
But with method synthetic compound 15,16,17,18,19,20,21,22,24,25,26,27,28,29,32,33.
Embodiment 5.
N-[4-(1-dimethylamino) ethylidene amino) phenyl]-2 chlorobenzamides (compound 2) synthetic:
0.01 mole (II) is dissolved in the 30ml dry-out benzene, on ice bath, is chilled to 5 ℃.Under agitation add 0.012 mole the Benzoyl chloride that drips in the 10ml dry-out benzene, finish stir again tremble 2 hours after, filter solid.Use the dehydrated alcohol recrystallization.Collect crystallization and put into the moisture eliminator inner drying after with absolute ethanol washing.
M·p.284～286
Molecular formula: C 17H 17ON 3Molecular weight: 316.5
Calculated value: N=13.27%, Cl=11.22%
Experimental value N=13.54%, Cl=11.37%
N＝13.45％， Cl＝11.48％
But with the method synthetic compound: 1,3,4,13,14,35.
Embodiment 6.
N-[4-(1-dimethylamino ethylidene amino) phenyl], the preparation of 1.4-diformazan acid diamide (compound 36):
0.02 mole (II) is dissolved in the 50ml dry-out benzene, solution places ice bath to be cooled to 5 ℃ in advance, stir the solution that the p-phthaloyl chloride that drips 0.01 mole down is dissolved in the 20ml dry-out benzene, slowly be warming up to room temperature after finishing, stir after 2 hours, filter solid, after 2 dryings of benzene washing, recrystallization in DMF.
Element divides folding. calculated value N=11.52%
Experimental value N=11.47%, 11.81%
Embodiment 7.
The preparation of 4-(1-dimethyl ethylidene amino) phenyl-2 hydroxyl 4-chlorine nitrogen benzide cresols:
0.01 mole adds 5ml concentrated hydrochloric acid and 25ml water, this mixture places ice bath to be cooled to 0.01 mole of Sodium Nitrite that is dissolved in 5ml water of 0 ℃ of dropping and makes diazonium salt.This is reaction solution (I)
Other gets 0.01 mole fortified phenol, is dissolved in the mixed solution of 20ml ethanol and 10ml water, and this liquid starts agitator when being cooled to 5 ℃, and dropwise reaction liquid I carries out coupled reaction, after finishing, stirs after 2 hours, with the neutralization of 0.1N NaOH solution, transfers to PH7.Filter to such an extent that fold solid, the washing after drying is used ethyl alcohol recrystallization
223 ℃ of molecular formula C of Mp 16H 17OCLN 4Molecular weight 316.5
Element divides folding: calculated value: N=13.27%, Cl=11.22%
Experimental value: N=12.98%, 13.15%
Cl＝11.34％，11.19％

Claims (5)

1, amino benzene carbon amidine derivative and physiologically acceptable salt thereof is characterized in that its general structure is as follows:
Figure C9611636000021
Y is CONH base or CH=N base in the formula; R is C 1-C 5Low alkyl, halo C 1-C 5Low alkyl and
Figure C9611636000022
Wherein, n=0,1, X is H, C 1-C 5Low alkyl, C 1-C 5Low-alkoxy, nitro, halogen and hydroxyl; R 1, R 2And R 3Be C identical or inequality 1-C 5Low alkyl; When Y was the CONH base, R was C 1-C 5Low alkyl, halo C 1-C 5Low alkyl and
Figure C9611636000023
Wherein, n=0,1, X is hydrogen, C 1-C 5Low alkyl, C 1-C 5Low-alkoxy, nitro, halogen and hydroxyl; R 1, R 2And R 3Be C identical or inequality 1-C 5Low alkyl; When Y was the CH=N base, R was C 1-C 5Low alkyl and
Figure C9611636000024
Wherein, n=0,1, X is hydrogen, halogen, hydroxyl, nitro and C 1-C 5Low-alkoxy; R 1, R 2And R 3Be C identical or inequality 1-C 5Low alkyl; When Y is the N=N base,
R is a substituted aryl; R 1, R 2And R 3Be C identical or inequality 1-C 5Low alkyl.
2,, it is characterized in that R is C when Y is the CONH base according to the described amino-benzene amidine derivative of claim 1 1-C 5Low alkyl, halo C 1-C 5Low alkyl and Wherein, n=0,1, X is H, C 1-C 5Low alkyl, C 1-C 5Low-alkoxy, nitro, halogen and hydroxyl.
3,, it is characterized in that R is C when Y is the CH=N base according to the described amino-benzene amidine derivative of claim 1 1-C 5Low alkyl and Wherein, n=0,1, X is hydrogen, halogen, hydroxyl, nitro and C 1-C 5Low-alkoxy.
4, according to the preparation method of the described amino-benzene amidine derivative of claim 1, it is characterized in that:
(1). p-Nitroaniline do starting raw material with Compound carries out condensation reaction and gets N '-(4-nitrophenyl) N in the presence of catalyzer in anhydrous solvent, the disubstituted amidine compound of N-(I), and its structural formula is:
(2). compound (I) is in the presence of appropriate catalyst, and the reduction nitro becomes amido to get N '-(4-aminophenyl) N, the disubstituted amidine compound of N-(II),
Its structural formula is:
(3) compound (II) and the aldehyde that replaces in suitable organic solvent, react (III) compound, its structural formula is Wherein R is C 1-C 5Low alkyl and
Figure C9611636000042
Wherein, n=0,1, X is hydrogen, halogen, hydroxyl, nitro and C 1-C 5Low-alkoxy;
(4) compound (II) and the acyl chlorides that replaces or replace acid anhydrides in anhydrous solvent, react amide compound (IV), its structural formula is:
Figure C9611636000043
Wherein R is C 1-C 5Low alkyl, halo C 1-C 5Low alkyl and
Figure C9611636000044
Wherein, n=0,1, X is hydrogen, C 1-C 5Low alkyl, C 1-C 5Low-alkoxy, nitro, halogen and hydroxyl;
(5) compound (II) makes diazonium salt with Sodium Nitrite and gets compound (V) with the substituted aryl effect again, and its structural formula is
Figure C9611636000045
Wherein R is a substituted aryl;
R in the above compound 1, R 2, and R 3Be C identical or inequality 1-C 5Low alkyl.
5, the application in the chemical agent of the anti-crust of preparation Nippostrongylus, hookworm, pinworm, roundworm according to described amino-benzene amidine derivative of claim 1 and physiologically acceptable salt thereof.
CN 96116360 1996-05-16 1996-05-16 Amino benzene carbon amidine derivative and its use Expired - Fee Related CN1112353C (en)

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CN104945287B (en) * 2015-06-12 2017-06-13 苏州大学张家港工业技术研究院 A kind of synthetic method of the acid inner salt compound of amidine
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