CN111228231B - Preparation method of potassium chloride sustained-release tablet - Google Patents
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- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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Abstract
The invention belongs to the technical field of biological medicines, and particularly relates to a preparation method of a potassium chloride sustained-release tablet, which comprises the following raw and auxiliary materials of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate: the potassium chloride and the hydrogenated cottonseed oil are crushed, mixed, sieved, mixed again, extruded by hot melting, granulated while hot, added with colloidal silicon dioxide and magnesium stearate after granulation, mixed completely and tabletted to obtain the sustained-release tablet. Research shows that the slow release tablet prepared by the process method still meets the requirement of quality standard after stability test.
Description
Technical Field
The invention belongs to the technical field of biological medicines, and particularly relates to a preparation method of a potassium chloride sustained-release tablet.
Background
The potassium chloride is a clinically common electrolyte balance regulating medicament, is available in the early market and has definite clinical curative effect. Because potassium chloride has irritation to gastrointestinal tract, can cause nausea, vomit and inappetence, can cause gastric ulcer and duodenal ulcer, and common oral preparations are easy to cause peak-valley fluctuation to generate obvious adverse reactions, the sustained-release preparation is developed and marketed by people. The potassium chloride sustained release preparation can slowly and uniformly release the medicine in the gastrointestinal tract, has stable blood concentration, stable potassium in the blood and long action time, effectively reduces the irritation of the gastrointestinal tract and the adverse reaction, and is a more ideal medicinal potassium supplement preparation.
Potassium chloride belongs to water-soluble components, and the sustained-release tablets prepared from the potassium chloride have good clinical advantages, and a hot-melt extrusion process method is mostly adopted in the prior art, but the whole process research is not deeply researched, so that the potassium chloride sustained-release tablets have important significance in deep process research.
Disclosure of Invention
For the reasons, the applicant finds out through research that a novel preparation method of the potassium chloride sustained-release tablet is obtained, and the preparation method comprises the following steps: the potassium chloride and the hydrogenated cottonseed oil are crushed, mixed, sieved, mixed again, extruded by hot melting, granulated while hot, added with colloidal silicon dioxide and magnesium stearate after granulation, mixed completely and tabletted to obtain the sustained-release tablet. Research shows that the slow release tablet prepared by the process method still meets the requirement of quality standard after stability test.
The invention is realized by the following technical scheme.
A preparation method of a chlorinating agent sustained release tablet is characterized in that the preparation method comprises the following steps: crushing potassium chloride and hydrogenated cottonseed oil, mixing, sieving, mixing, hot-melt extruding, granulating, adding colloidal silicon dioxide and magnesium stearate, mixing, and tabletting to obtain sustained release tablet.
The preparation method of the sustained-release tablet comprises the following steps:
(1) Crushing: taking potassium chloride, crushing, and screening by a 35-mesh screen to obtain crushed potassium chloride; crushing hydrogenated cottonseed oil, and sieving with a 35-mesh sieve to obtain crushed hydrogenated cottonseed oil; taking the colloidal silica, crushing, and screening by a 35-mesh screen to obtain crushed colloidal silica; taking magnesium stearate, crushing, and screening by a 35-mesh screen to obtain crushed magnesium stearate;
(2) Mixing, sieving and remixing: adding the crushed hydrogenated cottonseed oil into a mixer, adding crushed potassium chloride with the same weight as the hydrogenated cottonseed oil, adjusting the rotating speed of the mixer to 10rpm, mixing for 5 minutes, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, adding the rest crushed potassium chloride, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, sieving the mixture with a 14-mesh sieve, then placing the mixture into the mixer, adjusting the rotating speed of the mixer to 15rpm, and mixing for 15 minutes to obtain a mixture;
(3) Adding the mixture obtained in the step (2) into a hot-melt extruder, wherein the screw speed is 500rpm, and the barrel temperature is as follows in sequence:
55 +/-2-62 +/-62 ℃ +/-2-62 deg.C + -2-53 deg.C + -2 deg.C; the blanking speed is 100kg/h, and no mouth mold exists; obtaining extruded particles; finishing the extruded particles while the extruded particles are hot to obtain particles I;
(4) And (4) finishing the granules I obtained in the step (3) to obtain granules II, completely mixing the granules II with the crushed colloidal silicon dioxide and the crushed magnesium stearate, and tabletting to obtain the sustained-release tablets.
Wherein the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 450-550:150-160:3-4:6-7.
Wherein the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 500:156:3.3:6.7.
wherein the hot granule finishing process in the step (3) comprises the following steps: the extruded granules were placed in a granulator with a screen of 4X 4mm, square holes, 600rpm to give granules I. .
Wherein the whole grain process in the step (4) comprises the following steps: the granulate I was placed in a pulverizer at a feed rate of 2.5s/T,1000rpm,2mm sieve, to give granulate II.
Detailed Description
The technical solutions of the present invention are described below with specific examples, but the scope of the present invention is not limited thereto.
The embodiments described in this specification are merely illustrative of implementations of the inventive concept and the scope of the present invention should not be considered limited to the specific forms set forth in the embodiments but rather by the equivalents thereof as may occur to those skilled in the art upon consideration of the present inventive concept. While the following embodiments of the invention have been described, the invention is not limited to the specific embodiments and applications described above, which are intended to be illustrative, instructive, and not limiting. Those skilled in the art, having the benefit of this disclosure, may effect numerous modifications thereto without departing from the scope of the invention as defined by the appended claims.
The following tests are conclusion tests of research personnel based on multiple creative tests and on the technical scheme to be protected by the invention.
Preparation examples
Example 1
The preparation comprises the following raw and auxiliary materials: the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 500:156:3.3:6.7.
the preparation method of the sustained-release tablet comprises the following steps:
(1) Crushing: taking potassium chloride, crushing, and screening by a 35-mesh screen to obtain crushed potassium chloride; crushing hydrogenated cottonseed oil, and sieving with a 35-mesh sieve to obtain crushed hydrogenated cottonseed oil; taking the colloidal silicon dioxide, crushing, and screening by a 35-mesh screen to obtain crushed colloidal silicon dioxide; taking magnesium stearate, crushing, and screening by a 35-mesh screen to obtain crushed magnesium stearate;
(2) Mixing, sieving and remixing: adding the crushed hydrogenated cottonseed oil into a mixer, adding crushed potassium chloride with the same weight as the hydrogenated cottonseed oil, adjusting the rotating speed of the mixer to 10rpm, mixing for 5 minutes, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, adding the rest crushed potassium chloride, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, sieving the mixture with a 14-mesh sieve, then placing the mixture into the mixer, adjusting the rotating speed of the mixer to 15rpm, and mixing for 15 minutes to obtain a mixture;
(3) Adding the mixture obtained in the step (2) into a hot-melt extruder, wherein the screw speed is 500rpm, and the barrel temperature is as follows in sequence:
53-60-51 ℃; the blanking speed is 100kg/h, and no mouth mold is used; obtaining extruded particles; granulating the extruded particles while the extruded particles are hot, putting the extruded particles into a granulator, and screening the granules with a screen of 4 x 4mm and square holes at 600rpm to obtain particles I;
(4) Granulating the granules I obtained in the step (3): putting the granules I into a pulverizer with a feeding speed of 2.5s/T and a screen of 1000rpm and 2mm to obtain granules II, completely mixing the granules II with the pulverized colloidal silicon dioxide and the pulverized magnesium stearate, and tabletting to obtain the sustained-release tablets.
Example 2
The preparation comprises the following raw and auxiliary materials: the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 500:156:3.3:6.7.
the preparation method of the sustained-release tablet comprises the following steps:
(1) Crushing: taking potassium chloride, crushing, and screening by a 35-mesh screen to obtain crushed potassium chloride; crushing hydrogenated cottonseed oil, and sieving with a 35-mesh sieve to obtain crushed hydrogenated cottonseed oil; taking the colloidal silica, crushing, and screening by a 35-mesh screen to obtain crushed colloidal silica; taking magnesium stearate, crushing, and screening by a 35-mesh screen to obtain crushed magnesium stearate;
(2) Mixing, sieving and remixing: adding the crushed hydrogenated cottonseed oil into a mixer, adding crushed potassium chloride with the same weight as the hydrogenated cottonseed oil, adjusting the rotating speed of the mixer to 10rpm, mixing for 5 minutes, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, adding the rest crushed potassium chloride, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, sieving the mixture with a 14-mesh sieve, then placing the mixture into the mixer, adjusting the rotating speed of the mixer to 15rpm, and mixing for 15 minutes to obtain a mixture;
(3) Adding the mixture obtained in the step (2) into a hot-melt extruder, wherein the screw speed is 500rpm, and the barrel temperature is as follows in sequence:
55-62-53 ℃; the blanking speed is 100kg/h, and no mouth mold exists; obtaining extruded particles; granulating the extruded particles while the extruded particles are hot, putting the extruded particles into a granulator, and screening with a screen of 4 x 4mm and square holes at 600rpm to obtain particles I;
(4) Granulating the granules I obtained in the step (3): putting the granules I into a pulverizer with a feeding speed of 2.5s/T and a screen of 1000rpm and 2mm to obtain granules II, completely mixing the granules II with the pulverized colloidal silicon dioxide and the pulverized magnesium stearate, and tabletting to obtain the sustained-release tablets.
Example 3
The preparation comprises the following raw and auxiliary materials: the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 500:156:3.3:6.7.
the preparation method of the sustained-release tablet comprises the following steps:
(1) Crushing: taking potassium chloride, crushing, and screening by a 35-mesh screen to obtain crushed potassium chloride; crushing hydrogenated cottonseed oil, and sieving with a 35-mesh sieve to obtain crushed hydrogenated cottonseed oil; taking the colloidal silicon dioxide, crushing, and screening by a 35-mesh screen to obtain crushed colloidal silicon dioxide; taking magnesium stearate, crushing, and screening by a 35-mesh screen to obtain crushed magnesium stearate;
(2) Mixing, sieving and remixing: adding the crushed hydrogenated cottonseed oil into a mixer, adding crushed potassium chloride with the same weight as the hydrogenated cottonseed oil, adjusting the rotating speed of the mixer to 10rpm, mixing for 5 minutes, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, adding the rest crushed potassium chloride, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, sieving the mixture with a 14-mesh sieve, then placing the mixture into the mixer, adjusting the rotating speed of the mixer to 15rpm, and mixing for 15 minutes to obtain a mixture;
(3) Adding the mixture obtained in the step (2) into a hot-melt extruder, wherein the screw speed is 500rpm, and the barrel temperature is as follows in sequence:
57-64-55 ℃; the blanking speed is 100kg/h, and no mouth mold exists; obtaining extruded particles; granulating the extruded particles while the extruded particles are hot, putting the extruded particles into a granulator, and screening with a screen of 4 x 4mm and square holes at 600rpm to obtain particles I;
(4) Granulating the granules I obtained in the step (3): putting the granules I into a pulverizer with a feeding speed of 2.5s/T and a screen of 1000rpm and 2mm to obtain granules II, completely mixing the granules II with the pulverized colloidal silicon dioxide and the pulverized magnesium stearate, and tabletting to obtain the sustained-release tablets.
Comparative example 1
The preparation comprises the following raw and auxiliary materials: the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 500:156:3.3:6.7.
the preparation method of the sustained-release tablet comprises the following steps:
(1) Crushing: taking potassium chloride, crushing, and screening by a 35-mesh screen to obtain crushed potassium chloride; crushing hydrogenated cottonseed oil, and sieving with a 35-mesh sieve to obtain crushed hydrogenated cottonseed oil; taking the colloidal silicon dioxide, crushing, and screening by a 35-mesh screen to obtain crushed colloidal silicon dioxide; taking magnesium stearate, crushing, and screening by a 35-mesh screen to obtain crushed magnesium stearate;
(2) Mixing: taking crushed hydrogenated cottonseed oil and crushed potassium chloride, putting the crushed hydrogenated cottonseed oil and the crushed potassium chloride into a mixer, and mixing for 15 minutes at the rotating speed of 15rpm to obtain a mixture;
(3) Adding the mixture obtained in the step (2) into a hot-melt extruder, wherein the screw speed is 500rpm, and the barrel temperature is as follows in sequence:
55-62-53 ℃; the blanking speed is 100kg/h, and no mouth mold is used; obtaining extruded particles; granulating the extruded particles while the extruded particles are hot, putting the extruded particles into a granulator, and screening with a screen of 4 x 4mm and square holes at 600rpm to obtain particles I;
(4) Granulating the granules I obtained in the step (3): putting the granules I into a pulverizer with a feeding speed of 2.5s/T and a screen of 1000rpm and 2mm to obtain granules II, completely mixing the granules II with the pulverized colloidal silicon dioxide and the pulverized magnesium stearate, and tabletting to obtain the sustained-release tablets.
Comparative example 2
The preparation comprises the following raw and auxiliary materials: the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 500:156:3.3:6.7.
the preparation method of the sustained-release tablet comprises the following steps:
(1) Crushing: taking potassium chloride, crushing, and screening by a 35-mesh screen to obtain crushed potassium chloride; crushing hydrogenated cottonseed oil, and sieving with a 35-mesh sieve to obtain crushed hydrogenated cottonseed oil; taking the colloidal silica, crushing, and screening by a 35-mesh screen to obtain crushed colloidal silica; taking magnesium stearate, crushing, and screening by a 35-mesh screen to obtain crushed magnesium stearate;
(2) Mixing, sieving and remixing: adding the crushed hydrogenated cottonseed oil into a mixer, adding crushed potassium chloride with the same weight as the hydrogenated cottonseed oil, adjusting the rotating speed of the mixer to 10rpm, mixing for 5 minutes, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, adding the rest crushed potassium chloride, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, sieving the mixture with a 14-mesh sieve, then placing the mixture into the mixer, adjusting the rotating speed of the mixer to 15rpm, and mixing for 15 minutes to obtain a mixture;
(3) Adding the mixture obtained in the step (2) into a hot-melt extruder, wherein the screw speed is 500rpm, and the barrel temperature is as follows in sequence:
55-62-53 ℃; the blanking speed is 100kg/h, and no mouth mold exists; obtaining extruded particles to obtain particles I;
(4) Granulating the granules I obtained in the step (3): putting the granules I into a pulverizer with a feeding speed of 2.5s/T and a screen of 1000rpm and 2mm to obtain granules II, completely mixing the granules II with the pulverized colloidal silicon dioxide and the pulverized magnesium stearate, and tabletting to obtain the sustained-release tablets.
Comparative example 3
The preparation comprises the following raw and auxiliary materials: the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 500:156:3.3:6.7.
the preparation method of the sustained-release tablet comprises the following steps:
(1) Crushing: taking potassium chloride, crushing, and screening by a 35-mesh screen to obtain crushed potassium chloride; crushing hydrogenated cottonseed oil, and sieving with a 35-mesh sieve to obtain crushed hydrogenated cottonseed oil; taking the colloidal silicon dioxide, crushing, and screening by a 35-mesh screen to obtain crushed colloidal silicon dioxide; taking magnesium stearate, crushing, and screening by a 35-mesh screen to obtain crushed magnesium stearate;
(2) Mixing, sieving and remixing: adding the crushed hydrogenated cottonseed oil into a mixer, adding crushed potassium chloride with the same weight as the hydrogenated cottonseed oil, adjusting the rotating speed of the mixer to 10rpm, mixing for 5 minutes, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, adding the rest crushed potassium chloride, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, sieving the mixture with a 14-mesh sieve, then placing the mixture into the mixer, adjusting the rotating speed of the mixer to 15rpm, and mixing for 15 minutes to obtain a mixture;
(3) Adding the mixture obtained in the step (2) into a hot-melt extruder, wherein the screw speed is 500rpm, and the barrel temperature is as follows in sequence:
55-63-60 ℃; the blanking speed is 100kg/h, and no mouth mold exists; obtaining extruded particles; granulating the extruded particles while the extruded particles are hot, putting the extruded particles into a granulator, and screening the granules with a screen of 4 x 4mm and square holes at 600rpm to obtain particles I;
(4) Granulating the granules I obtained in the step (3): putting the granules I into a pulverizer with a feeding speed of 2.5s/T and a screen of 1000rpm and 2mm to obtain granules II, completely mixing the granules II with the pulverized colloidal silicon dioxide and the pulverized magnesium stearate, and tabletting to obtain the sustained-release tablets.
Comparative example 4
The preparation comprises the following raw and auxiliary materials: the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 500:156:3.3:6.7.
the preparation method of the sustained-release tablet comprises the following steps:
(1) Crushing: taking potassium chloride, crushing, and screening by a 35-mesh screen to obtain crushed potassium chloride; crushing hydrogenated cottonseed oil, and sieving with a 35-mesh sieve to obtain crushed hydrogenated cottonseed oil; taking the colloidal silicon dioxide, crushing, and screening by a 35-mesh screen to obtain crushed colloidal silicon dioxide; taking magnesium stearate, crushing, and screening by a 35-mesh screen to obtain crushed magnesium stearate;
(2) Mixing, sieving and remixing: adding the crushed hydrogenated cottonseed oil into a mixer, adding crushed potassium chloride with the same weight as the hydrogenated cottonseed oil, adjusting the rotating speed of the mixer to 10rpm, mixing for 5 minutes, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, adding the rest crushed potassium chloride, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, sieving the mixture with a 14-mesh sieve, then placing the mixture into the mixer, adjusting the rotating speed of the mixer to 15rpm, and mixing for 15 minutes to obtain a mixture;
(3) Adding the mixture obtained in the step (2) into a hot-melt extruder, wherein the screw speed is 500rpm, and the barrel temperature is as follows in sequence:
55-62-53 ℃; the blanking speed is 100kg/h, and no mouth mold exists; obtaining extruded particles; granulating the extruded particles while the extruded particles are hot, putting the extruded particles into a granulator, and screening the granules with a screen of 4 x 4mm and square holes at 600rpm to obtain particles I;
(4) And (4) completely mixing the granules I obtained in the step (3) with the crushed colloidal silicon dioxide and the crushed magnesium stearate, and tabletting to obtain the sustained-release tablet.
Coating the sustained-release tablets: the coating liquid is: film coating premix (gastric soluble form) (opadry II85F18422 WHITE): the weight ratio of the deionized water is as follows: 23.31:116.55. packaging the coated aluminum-plastic bubble cap.
Dissolution rate: taking the sustained-release tablets of different examples and comparative examples, according to the determination method of dissolution rate and release rate (2015 edition pharmacopoeia general rule 0931, th)Two method), using 900ml of water as dissolution medium, rotating speed 50 r/min, operating according to the method, taking 25ml of solution and filtering at 2 hours, 4 hours and 8 hours respectively, and instantly supplementing dissolution medium with the same temperature and volume, taking 20ml of continuous filtrate with precise amount, adding 4 drops of potassium chromate indicator, titrating with silver nitrate titration solution (0.01 mol/L) until the solution shows orange yellow, each lml of silver nitrate titration solution (0.01 mol/L) is equivalent to 0.7455mg of KC1. The dissolution amount of each tablet of the product in 2 hours, 4 hours and 8 hours is respectively 5-65%, 50-85% and more than 85% of the marked amount. Original research imported preparation (FDA original research reagent potassium chloride sustained release tablet (trade name)
) The dissolution rate is as follows: 2h:50 percent; 4h:66 percent; 8h:86 percent.
And (3) stability test: taking the packaged potassium chloride sustained-release tablets (packaged by aluminum-plastic after coating), and standing for 6 months at the temperature of 40 +/-2 ℃ and the relative humidity of 75 +/-5%. Samples were taken at the end of 1 month, 2 months, 3 months and 6 months of the test period, and the dissolution rates of the different formulations were determined, and the test results are shown in tables 1-4.
TABLE 1 dissolution of the formulations for months
TABLE 2 dissolution of the formulations for months
TABLE 3 dissolution of the formulations for months
TABLE 4 dissolution of the formulations for 6 months
And (4) test conclusion: (1) The mixing step of the raw materials and the auxiliary materials is changed (comparative example 1), the hot granule finishing step is removed (comparative example 2), the temperature of a machine barrel in an extrusion process is changed (comparative example 3), the granule finishing process step after hot granule finishing is removed (comparative example 4), and the dissolution rate of the sustained release tablet obtained by the process method is unqualified after a stability test. (2) From the above comparative test results, it is shown that the process of the present invention is an organic whole, and the process parameters cannot be adjusted at will, but the process of the present invention can be obtained only by intensive research.
Claims (3)
1. A preparation method of potassium chloride sustained release tablets comprises the following steps of:
(1) Crushing: taking potassium chloride, crushing, and screening by a 35-mesh screen to obtain crushed potassium chloride; crushing hydrogenated cottonseed oil, and sieving with a 35-mesh sieve to obtain crushed hydrogenated cottonseed oil; taking the colloidal silicon dioxide, crushing, and screening by a 35-mesh screen to obtain crushed colloidal silicon dioxide; taking magnesium stearate, crushing, and screening by a 35-mesh screen to obtain crushed magnesium stearate;
(2) Mixing, sieving and remixing: adding the crushed hydrogenated cottonseed oil into a mixer, adding crushed potassium chloride with the same weight as the hydrogenated cottonseed oil, adjusting the rotating speed of the mixer to 10rpm, mixing for 5 minutes, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, adding the rest crushed potassium chloride, adjusting the rotating speed of the mixer to 15rpm, mixing for 5 minutes, sieving the mixture with a 14-mesh sieve, then placing the mixture into the mixer, adjusting the rotating speed of the mixer to 15rpm, and mixing for 15 minutes to obtain a mixture;
(3) Adding the mixture obtained in the step (2) into a hot-melt extruder, wherein the screw speed is 500rpm, and the barrel temperature is as follows in sequence:
55 +/-2-62 +/-62 ℃ +/-2-62 deg.C + -2-53 deg.C + -2 deg.C; the blanking speed is 100kg/h, and no mouth mold is used; obtaining extruded particles; granulating the extruded particles while the extruded particles are hot, putting the extruded particles into a granulator, and screening with a screen of 4 x 4mm and square holes at 600rpm to obtain particles I;
(4) And (3) granulating the granules I obtained in the step (3), putting the granules I into a grinder, feeding at 2.5s/T at 1000rpm with a 2mm screen to obtain granules II, completely mixing the granules II with the ground colloidal silicon dioxide and the ground magnesium stearate, and tabletting to obtain the sustained-release tablets.
2. The method for preparing a potassium chloride sustained release tablet according to claim 1, wherein the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 450-550:150-160:3-4:6-7.
3. The method for preparing a potassium chloride sustained release tablet according to claim 1, wherein the weight ratio of potassium chloride, hydrogenated cottonseed oil, colloidal silicon dioxide and magnesium stearate is as follows: 500:156:3.3:6.7.
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