CN111205971B - Sampling tube - Google Patents
Sampling tube Download PDFInfo
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- CN111205971B CN111205971B CN202010321281.6A CN202010321281A CN111205971B CN 111205971 B CN111205971 B CN 111205971B CN 202010321281 A CN202010321281 A CN 202010321281A CN 111205971 B CN111205971 B CN 111205971B
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- tube body
- inner tube
- tube
- sampling
- sealing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
Abstract
The invention discloses a sampling tube which comprises an inner tube, an outer tube and a sealing plug for plugging a water outlet of the sampling tube of the outer tube, wherein the inner tube comprises an inner tube body, a piston and a sealing cover, the two ends of the inner tube body are through holes, the piston is sleeved at a first end of the inner tube body, the sealing cover is arranged at a second end of the inner tube body and is used for plugging the inner tube body, the first end and the second end are opposite to the through hole of the inner tube body, the first end of the inner tube body is provided with a through hole for communicating the inner side of the inner tube body with the outer side of the. The outer pipe comprises an outer pipe body, the two ends of the outer pipe body are through holes, the first end of the outer pipe body is a water outlet of the sampling pipe, the second end of the outer pipe body is sleeved outside the inner pipe body, and the piston is connected with the inner wall of the outer pipe body in a sliding and sealing mode; the sealing plug is detachably connected with the water outlet of the sampling pipe. The inner tube body is used for storing and collecting samples. The sampling tube effectively avoids secondary virus propagation caused by aerosol generated by similar viruses, and the use safety is improved.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a sampling tube.
Background
When detecting substances such as new coronavirus, SARS, H1N1 influenza, avian influenza, respiratory tract viruses such as hand-foot-mouth and the like and enteroviruses, a disposable sampling swab is generally adopted to extract secretion from the nasopharynx part, and after the extraction is finished, the disposable sampling swab with pathogens is inserted into a virus sampling tube storage liquid.
The traditional sampling pipe for storing the virus is a single-layer pipe, namely, the single-layer pipe comprises a pipe body and a sealing cover for sealing the pipe orifice of the pipe body. In operation, a user places a disposable sampling swab into a tube containing a preservation fluid. If mishandled, the disposable sampling swab is placed in contact with the viral vessel wall and the extracted pathogens are not completely soaked in the preservation fluid to inactivate the virus. If a doctor or a detector extracts a pathogen sample in nucleic acid detection, aerosol viruses which are not completely inactivated in the sampling tube are easily diffused into the air while the sealing cover is opened, so that the viruses are spread for the second time, the secondary cross infection is caused, the personal harm is caused, and the use safety of the sampling tube is low.
Therefore, how to improve the safety of the sampling tube is a technical problem to be solved by those skilled in the art.
Disclosure of Invention
The object of the present invention is to provide a sampling tube with improved safety in use.
To achieve the above object, the present invention provides a sampling tube comprising:
the inner tube comprises an inner tube body, a piston and a sealing cover, wherein the two ends of the inner tube body are through holes, the piston is arranged at the first end of the inner tube body in a sealing mode, the sealing cover is arranged at the second end of the inner tube body and used for sealing the second end of the inner tube body, a liquid outlet at the bottom of the inner tube is formed in the first end of the inner tube body and used for communicating the inner side of the inner tube body with the outer side of the inner tube body, the first end and the second end are opposite to the through holes of the inner tube body, a collected sample is stored in the inner tube body, and a sample storage;
the outer tube comprises an outer tube body, the two ends of the outer tube body are through holes, the first end of the outer tube body is a sampling tube water outlet, the second end of the outer tube body is sleeved outside the inner tube body, the piston is connected with the inner wall of the outer tube body in a sliding and sealing mode, and the second end of the outer tube body is located between the sealing cover and the piston;
and the sealing plug is used for plugging the water outlet of the sampling tube of the outer tube, and the sealing plug is detachably connected with the water outlet of the sampling tube.
Preferably, an impurity filtering piece is arranged on the upstream of the water outlet of the sampling pipe of the outer pipe body.
Preferably, the impurity filter is filter cotton.
Preferably, the first end of the outer tube body is a conical tube body structure with an inner circumference tapering towards the water outlet.
Preferably, the end surface of the piston and the end surface of the conical pipe body structure are conical surface structures which can be attached to each other.
Preferably, the sealing plug is in threaded connection or plug connection with the outer wall of the water outlet of the sampling pipe.
Preferably, the inner tube further comprises a sealing sleeve sleeved outside the second end of the inner tube body, and the end of the sealing sleeve can abut against the end of the outer tube body.
Preferably, the aperture of the liquid outlet at the bottom of the inner tube is 0.3mm-1 mm.
Preferably, the sealing cap is threadedly coupled to the second end of the inner tubular body.
Preferably, a seal ring capable of abutting against an end face of the second end of the inner pipe body is provided inside the seal cover.
In the technical scheme, the sampling tube provided by the invention comprises an inner tube, an outer tube and a sealing plug for plugging a water outlet of the sampling tube of the outer tube, wherein the inner tube comprises an inner tube body with through holes at two ends, a piston arranged at a first end of the inner tube body by a sealing sleeve and a sealing cover arranged at a second end of the inner tube body, the sealing cover is used for plugging the second end of the inner tube body, the first end and the second end are opposite to the through hole of the inner tube body, a liquid outlet at the bottom of the inner tube for communicating the inner side of the inner tube body with the outer side of the inner tube body is arranged at the first end of the inner tube body, a collected sample is. The outer pipe comprises an outer pipe body, the two ends of the outer pipe body are through holes, the first end of the outer pipe body is a water outlet of the sampling pipe, the second end of the outer pipe body is sleeved outside the inner pipe body, and the piston is connected with the inner wall of the outer pipe body in a sliding and sealing mode; the sealing plug is detachably connected with the water outlet of the sampling pipe. The inner tube body is used for storing and collecting samples. The second end of the outer tube body is located between the sealing cover and the piston.
In the sampling pipe that this application provided, constitute double-deck body structure by inner tube and outer tube, and the inner tube is used for preserving the sample of collection with interior. When the collected sample is extracted and stored, the sealing plug and the sealing cover are in sealing, and when the inner pipe moves in the direction away from the sealing plug, negative pressure can be formed in a cavity formed by the inner pipe and the inner part of the outer pipe. Due to the principle of negative pressure adsorption, and the inner tube is provided with the inner tube bottom liquid outlet, under the action of negative pressure, pathogen sample liquid in the inner tube can be adsorbed to the outer tube body through the inner tube bottom liquid outlet. Then, take off the sealed end cap of outer tube delivery port, promote the inner tube and to the first end motion of outer tube can realize the sample and discharge, need not to open sealed lid, consequently, avoided the virus secondary propagation that the aerosol that produces similar to the virus caused effectively, the safety in utilization of the sampling pipe that this application provided improves.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
FIG. 1 is a schematic structural diagram of a sampling tube according to an embodiment of the present invention;
FIG. 2 is a schematic structural view of an inner tube according to an embodiment of the present invention;
FIG. 3 is a schematic view of the inner tube shown in FIG. 2 along the A-A direction;
FIG. 4 is a schematic structural diagram of an outer tube according to an embodiment of the present invention;
fig. 5 is a schematic structural view of the outer tube shown in fig. 4 along the direction B-B.
Wherein in FIGS. 1-5:
1. an inner tube; 1-1, sealing cover; 1-2, sealing rings; 1-3, sealing sleeve; 1-4, an inner tube body; 1-5, a piston; 1-6, a liquid outlet at the bottom of the inner tube;
2. an outer tube; 2-1, an outer tube body; 2-2, impurity filtering; 2-3, water outlet of the sampling pipe;
3. and (6) sealing the plug.
Detailed Description
The core of the invention is to provide a sampling tube, which has improved use safety.
In order to make the technical solutions of the present invention better understood by those skilled in the art, the present invention will be further described in detail with reference to the accompanying drawings and embodiments.
Please refer to fig. 1 to 5.
In a specific implementation manner, the sampling tube provided by the specific embodiment of the present invention includes an inner tube 1, an outer tube 2, and a sealing plug 3 for plugging a water outlet 2-3 of the sampling tube of the outer tube 2, where the inner tube 1 includes an inner tube body 1-4 with through holes at both ends, a piston 1-5 sealed at a first end of the inner tube body 1-4, and a sealing cover 1-1 disposed at a second end of the inner tube body 1-4, the sealing cover 1-1 is used to plug the inner tube body 1-4, a first end of the inner tube body 1-4 is provided with an inner tube bottom liquid outlet for communicating an inner side of the inner tube body 1-4 with an outer side of the inner tube body 1-4, and the first end and the second end are opposite ends of the through holes of the. Specifically, when in use, the sample preservation solution is preset in the inner tube body 1-4.
Wherein, the piston 1-5 is preferably arranged at the second end of the inner tube body 1-4, in particular, the piston 1-5 is preferably a silica gel piston.
The aperture of the liquid outlet 1-6 at the bottom of the inner tube is 0.3mm-1mm, and specifically, the aperture of the liquid outlet 1-6 at the bottom of the inner tube can be 0.5mm or 0.7mm and the like.
The outer tube 2 comprises an outer tube body 2-1 with through holes at two ends, the first end of the outer tube body 2-1 is a water outlet 2-3 of the sampling tube, the second end of the outer tube body 2-1 is sleeved outside the inner tube body 1-4, and the piston 1-5 is connected with the inner wall of the outer tube body 2-1 in a sliding and sealing manner; the sealing plug 3 is detachably connected with the water outlet 2-3 of the sampling tube, and the second end of the outer tube body 2-1 is positioned between the sealing cover 1-1 and the piston 1-5.
In order to improve the detection effect, preferably, an impurity filtering piece 2-2 is arranged at the upstream of the water outlet 2-3 of the sampling pipe of the outer pipe body 2-1. In particular, the contaminant filter 2-2 may be an elastic filter structure. Wherein, the impurity filtering piece 2-2 is arranged at the bottom end of the outer tube body 2-1.
Preferably, the impurity filter 2-2 is filter cotton. Specifically, the contaminant filter 2-2 may filter contaminants from the virus specimen fluid.
In one embodiment, as shown in fig. 4, the first end of the outer tube body 2-1 is a conical tube structure with an inner circumference tapering toward the water outlet, and specifically, the inner circumference is a circumferential structure formed perpendicular to the axial direction of the outer tube body. In particular, the device can be composed of a plurality of sections of conical pipes. In order to facilitate the assembly of the sampling tube, preferably, the outer tube 2 is an integrally formed tube.
Preferably, the end face of the piston 1-5 and the end face of the conical tube structure are conical surface structures which can be attached to each other.
In a specific embodiment, the sealing plug 3 is in threaded connection with the outer wall of the water outlet 2-3 of the sampling tube, of course, the sealing plug 3 is installed at the position 2-3 of the water outlet of the sampling tube in a plugging manner, specifically, the sealing plug 3 is an elastic part, the sealing plug 3 is installed at the position 2-3 of the water outlet of the sampling tube in an expanding manner, and a worker pulls the sealing plug 3 outwards to separate the sealing plug 3 from the outer tube 2, so that the worker can conveniently disassemble and assemble the sealing plug 3.
Specifically, the inner tube 1 further comprises a sealing sleeve 1-3 sleeved outside the second end of the inner tube body 1-4. Specifically, when the inner tube 1 is pressed down to the limit position, the end part of the sealing sleeve 1-3 and the sealing cover 1-1 are abutted to realize the position limit of the inner tube 1. Specifically, the sealing sleeves 1-3 are coaxially wrapped and installed on the outer walls of the inner pipe bodies 1-4.
In order to avoid liquid accumulation and facilitate the processing of the sampling tube, the main structure of the main body of the outer tube body 2-1 and the main structure of the main body of the inner tube body 1-4 are preferably cylindrical structures.
Specifically, the sealing cover 1-1 is in threaded connection with the second end of the inner pipe body 1-4, so that the sealing performance is guaranteed, and meanwhile, a worker can conveniently open the sealing cover 1-1.
In order to improve the sealing property, the sealing cap 1-1 is preferably provided with a sealing ring 1-2 therein, which can abut against the end face of the second end of the inner pipe body 1-4. Specifically, the sealing ring 1-2 is coaxially arranged in the sealing cover 1-1.
Specifically, when the sampling tube is used, a disposable sampling swab is adopted to collect pathogens in the nasopharynx, the disposable sampling swab with the pathogens is placed into the inner tube body 1-4 containing inactivation preservation liquid to inactivate viruses, the piston 1-5 in the inner tube body 1-4 is located at one side close to the second end of the outer tube 2, and the inner tube body 1-4 is covered by the sealing cover 1-1 to be sealed and preserved.
When the pathogen sample in the inner tube 1 is extracted in the nucleic acid detection, the sealing cover 1-1 of the inner tube 1 is not needed to be opened, only the inner tube body 1-4 with the piston 1-5 needs to be pulled upwards from the outer tube 2, vacuum negative pressure is formed in the sampling tube under the action of the piston 1-5 because the bottom end of the outer tube 2 is sealed by the sealing plug 3, and the pathogen sample liquid in the inner tube body 1-4 is adsorbed into the outer tube 2 through the inner tube bottom liquid outlet 1-6 at the bottom end of the inner tube 1 by utilizing the negative pressure principle.
Then a sealing plug 3 of a through hole at the end part of the outer tube 2 is taken, the inner tube 1 with the piston 1-5 is pushed to move towards the first end of the outer tube 2, and the pathogen sample liquid in the outer tube 2 is injected into a specified pathogen detection device from a water outlet 2-3 of the sampling tube through the filter cotton in the outer tube 2.
And finally, a water outlet 2-3 of the sampling tube is blocked and sealed by a sealing plug 3, and a sealing sleeve 1-3 arranged on the outer wall of the inner tube 1 is inserted into the outer sampling tube for sealing, so that the virus existing in the tube cannot be diffused due to the sealing state, and then the medical waste is uniformly treated by professionals after high-temperature or ultraviolet sterilization.
When the pathogen sample liquid is extracted, the virus sample sealing cover 1-1 is not opened all the time, so that the virus which is not inactivated is prevented from diffusing into the air.
It can be known from the above description that, in the sampling tube provided in the embodiment of the present application, when the inner tube 1 can slide relative to the outer tube 2, and then the cavity formed by the inner tube 1 and the outer tube 2 can form a negative pressure, due to the principle of negative pressure adsorption, the pathogen sample liquid in the inner tube 1 is pumped out at the same time, the pathogen sample liquid is adsorbed into the outer tube 2 through the inner tube bottom liquid outlet 1-6 at the bottom end of the inner tube 1, and when the inner tube 1 is pushed to the first end of the outer tube 2, the sample can be discharged, and when the nasopharyngeal swab virus sample is extracted for nucleic acid detection, the cap does not need to be opened in the whole course, that is, the sealing cap 1-1 does not need to be opened, so that the secondary propagation of the virus caused by the aerosol similar to the virus is effectively avoided, and the use safety.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A sampling tube, comprising:
the inner pipe (1), the inner pipe (1) comprises an inner pipe body (1-4) with through holes at two ends, a piston (1-5) hermetically sleeved at the first end of the inner pipe body (1-4) and a sealing cover (1-1) arranged at the second end of the inner pipe body (1-4), the sealing cover (1-1) is used for plugging the second end of the inner pipe body (1-4), the first end and the second end are opposite ends of the through hole of the inner pipe body (1-4), the first end of the inner tube body (1-4) is provided with an inner tube bottom liquid outlet (1-6) which communicates the inner side of the inner tube body (1-4) and the outer side of the inner tube body (1-4), the inner tube body (1-4) is used for storing collected samples, and sample storing liquid is preset in the inner tube body (1-4);
the sampling tube comprises an outer tube (2), wherein the outer tube (2) comprises an outer tube body (2-1) with through holes at two ends, a sampling tube water outlet (2-3) is arranged at a first end of the outer tube body (2-1), a second end of the outer tube body (2-1) is sleeved outside the inner tube body (1-4), a piston (1-5) is connected with the inner wall of the outer tube body (2-1) in a sliding and sealing mode, and a second end of the outer tube body (2-1) is located between a sealing cover (1-1) and the piston (1-5);
and the sealing plug (3) is used for plugging the water outlet (2-3) of the sampling tube, and the sealing plug (3) is detachably connected with the water outlet (2-3) of the sampling tube.
2. The sampling tube according to claim 1, characterized in that an impurity filter (2-2) is provided upstream of the sampling tube water outlet (2-3) of the outer tube body (2-1).
3. The sampling tube according to claim 2, characterized in that the impurity filter (2-2) is a filter cotton.
4. The sampling tube according to claim 2, wherein the first end of the outer tube body (2-1) is a conical tube structure with an inner circumference tapering towards the water outlet.
5. The sampling tube according to claim 4, characterized in that the end surface of the piston (1-5) and the end surface of the conical tube body structure are conical surface structures which can be fitted to each other.
6. The sampling tube according to claim 1, wherein the sealing plug (3) is in threaded connection or plug connection with the outer wall of the water outlet (2-3) of the sampling tube.
7. The sampling tube according to claim 1, wherein the inner tube (1) further comprises a sealing sleeve (1-3) fitted over the outside of the second end of the inner tube body (1-4), the end of the sealing sleeve (1-3) being capable of abutting against the end of the outer tube body (2-1).
8. The sampling tube according to claim 1, wherein the pore size of the liquid outlet (1-6) at the bottom of the inner tube is 0.3mm-1 mm.
9. The sampling tube according to any of claims 1-8, wherein the sealing cap (1-1) is threadedly connected to the second end of the inner tube body (1-4).
10. The sampling tube according to claim 9, wherein the sealing cap (1-1) is provided internally with a sealing ring (1-2) adapted to abut against the end surface of the second end of the inner tube body (1-4).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010321281.6A CN111205971B (en) | 2020-04-22 | 2020-04-22 | Sampling tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010321281.6A CN111205971B (en) | 2020-04-22 | 2020-04-22 | Sampling tube |
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| Publication Number | Publication Date |
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| CN111205971A CN111205971A (en) | 2020-05-29 |
| CN111205971B true CN111205971B (en) | 2020-07-31 |
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| CN202010321281.6A Active CN111205971B (en) | 2020-04-22 | 2020-04-22 | Sampling tube |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111690526B (en) * | 2020-07-21 | 2023-05-16 | 武汉致远医疗科技有限公司 | Virus sampling tube and forming die thereof |
| CN114100703A (en) * | 2020-09-01 | 2022-03-01 | 上海脉迪机电技术有限公司 | Sampling swab conservator with pipetting function |
| CN112697765B (en) * | 2020-11-11 | 2023-02-10 | 上海应用技术大学 | Portable storage type surface enhanced Raman sensor, and preparation method, detection method and application thereof |
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| CN110487597A (en) * | 2019-09-04 | 2019-11-22 | 蔡林 | A kind of lactic acid bacteria (LAB) detection probe tube |
| DE102018218739B3 (en) * | 2018-11-01 | 2020-03-19 | Sarstedt Ag & Co. Kg | Blood collection tube and preparation method |
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2020
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| RU2244559C2 (en) * | 1999-12-10 | 2005-01-20 | Альфахиликс Аб | Device and method for extracting nucleic acids |
| DE102006010958A1 (en) * | 2006-03-06 | 2007-09-13 | Directif Gmbh | Method for carrying out a reaction for the amplification of a nucleic acid |
| CN206990268U (en) * | 2017-06-14 | 2018-02-09 | 杭州谱可检测技术有限公司 | A kind of Modified Chemical product sampler |
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| CN111205971A (en) | 2020-05-29 |
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