CN111195207A - Acid etching mineralizer for increasing adhesiveness of dentin - Google Patents
Acid etching mineralizer for increasing adhesiveness of dentin Download PDFInfo
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- CN111195207A CN111195207A CN202010060940.5A CN202010060940A CN111195207A CN 111195207 A CN111195207 A CN 111195207A CN 202010060940 A CN202010060940 A CN 202010060940A CN 111195207 A CN111195207 A CN 111195207A
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- dentin
- acid etching
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- fluoride
- phosphoric acid
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Abstract
An acid etching mineralizer for increasing the adhesiveness of dentin belongs to the technical field of oral cavity tooth body repairing agents. Soluble fluoride salt is added into acid etching agent phosphoric acid in a certain proportion. 0.5-5 g fluoride salt per 100ml 5-50% phosphoric acid. The fluoride which is used as a part of the treating agent and phosphoric acid jointly act on the dentin bonding surface, after the treatment agent is washed by water conventionally, the fluoride is generated while acid etching and demineralization are carried out and is deposited on the dentin surface and blocks dentin tubules, the exposure of collagen fibers on the acid etched dentin surface is reduced, the influence of liquid in the dentin tubules on bonding is reduced, the sensitivity of teeth to external stimulation is reduced, the mineralization of dentin is promoted, and the bonding and anti-aging performance is improved.
Description
Technical Field
The invention belongs to the technical field of oral cavity tooth repairing agents, and relates to an application of acid etching mineralization before dentin adhesion, which forms fluoride isolated tubule liquid on the surface of dentin or in dentin tubules, hardens dentin, improves adhesion and improves anti-aging performance.
Background
Dentin adhesion has been a problem in the oral cavity because dentin, unlike enamel, has large differences in both structure and physical and chemical properties, and dentin contains a large amount of organic matrix, which adversely affects adhesion. And a plurality of dentinal tubules extend from the pulp cavity to the surface of the dentin, dentin fluid is contained in the dentinal tubules, and external stimulation to the dentin can be transmitted to the pulp cavity through the dentinal tubules, so that discomfort is brought to a human body. After the pretreatment of the tooth surface with phosphoric acid, which was proposed by Buonocore in the 60's 20 th century, sensitivity problems caused by exposure of dentinal tubules due to acid etching and demineralization were revealed while adhesion was improved, and liquid in the exposed dentinal tubules adversely affected adhesion. In response to such problems, many of the world's oral materials academicians have proposed a number of solutions. For dentin sensitivity, clinical application of desensitizers and observation of self-compensation recovery of tooth bodies are prone to occur, the effect is slow, and the curative effect is unstable. The adhesive is updated from full acid etching to self acid etching, which makes remarkable progress, but has many problems, such as demineralization caused by acid etching and exposure of collagen fibers, which affect the anti-aging performance of dentin adhesion. Fluoride has been used for preventing dental caries in clinic for many years, the curative effect of fluoride is confirmed by the oral cavity, and the most remarkable application is that children teeth are coated with fluoride for preventing dental caries.
Disclosure of Invention
The invention relates to a novel acid etching and mineralization treatment method before dentin bonding, which organically integrates tooth sensitivity resistance, bonding force enhancement, ageing resistance enhancement, slow fluorine release after bonding to promote mineralization and caries prevention.
An acid etching mineralizer for increasing the adhesiveness of dentin is characterized in that a certain proportion of soluble fluoride salt such as sodium fluoride or stannous fluoride is added into acid etching agent phosphoric acid. Sodium fluoride or stannous fluoride and the like which are used as a part of treating agents act on a dentin bonding surface together with phosphoric acid, after the dentin bonding surface is washed by water conventionally, fluoride is generated and deposited on the surface of dentin and blocks dentin tubules while acid etching is carried out, the influence of liquid in the dentin tubules on bonding is reduced, the sensitivity of teeth to external stimulation is reduced, the mineralization of dentin is promoted, and the bonding and anti-aging performance is improved.
The phosphoric acid serving as the acid etching agent is 5-50 mass percent of phosphoric acid; the soluble fluoride salt is added in a proportion of 0.5 to 5 g per 100ml of 37% phosphoric acid.
Instead of phosphoric acid, other acids may be used, such as maleic acid or citric acid.
The acid etching mineralizer is used for acid etching mineralization before dentin bonding and is a treatment agent for further improving the bonding property.
The fluoride which is used as a part of the treating agent and phosphoric acid jointly act on the dentin bonding surface, after the treatment agent is washed by water conventionally, the fluoride is generated while acid etching and demineralization are carried out and is deposited on the dentin surface and blocks dentin tubules, the exposure of collagen fibers on the acid etched dentin surface is reduced, the influence of liquid in the dentin tubules on bonding is reduced, the sensitivity of teeth to external stimulation is reduced, the mineralization of dentin is promoted, and the bonding and anti-aging performance is improved.
The concentration of phosphoric acid and the amount of fluoride added can be adjusted as appropriate to achieve an excellent clinical effect.
Drawings
FIG. 1 SEM images of dentin surface of different scale sizes of conventional acid etched dentin surface using the reagent A (37% phosphoric acid); FIG. 2 SEM pictures of different scale dimensions of the dentin surface after treatment with the described reagent B (100ml of 37% phosphoric acid plus 1 g of sodium fluoride) in example 1.
Detailed Description
The present invention will be further illustrated with reference to the following examples, but the present invention is not limited to the following examples.
Example 1
The method comprises the following steps: the preparation method comprises the steps of selecting human premolar teeth (with informed consent of patients, removing root surface soft tissue residues by using a curette after removal, storing physiological saline at 4 ℃ for later use, and not exceeding 4 weeks) which are completely and have no caries and cracks in oral and maxillofacial surgery of oral medicine institute of capital medical university and are freshly removed due to orthodontics, embedding tooth roots by using self-setting resin, removing enamel by grinding, and exposing dentin to serve as a test piece for later use.
Equipment: scanning electron microscope (Phenom proX, Phenom-World B.V., the Netherlands), metallographic specimen pre-grinding machine (YM-2A, Shanghai metallographical mechanical equipment Co., Ltd.), low-speed cutting machine (Isomet 4000line Precision Saw, Buehler, USA), universal testing machine.
Materials: self-setting methyl methacrylate-based resin (dental materials factory, Shanghai medical instruments Ltd., short: self-setting resin), composite resin (Z250, 3M, USA), adhesive (singlebond, Japan), and acid etching agent (Gruma, Germany).
The experimental steps are as follows: the teeth were divided into control and experimental groups of 21 teeth each, which were then embedded with self-setting resin, enamel was cut along the enamel dentinal junction with a slow cutter, and fresh dentin surfaces were exposed as reagent-treated surfaces.
In the control group, the dentin was treated with a German Grummar acid etching agent, and the dentin was rinsed clean with running water and dried after acid etching for 30 seconds. Optionally selecting one tooth, observing the surface morphology by an electron microscope, limiting the bonding area with the diameter of 3 mm circle for the other 20 test pieces, coating the adhesive by a conventional method, carrying out photocuring, stacking a resin column with the height of 5 mm in the bonding area, randomly selecting 10 test pieces to carry out immediate shear test, and carrying out 6000 times of cold and hot circulation on the other 10 test pieces to carry out shear test (namely carrying out shear test on an aging test). The circulation conditions were one cycle of thirty seconds holding in water at 5 ℃ and five 55 ℃ respectively.
The experimental group was the same as the control group except that dentin was treated with the acid etching mineralizer described in the present invention (100ml of 37% phosphoric acid plus 1 g of sodium fluoride was used as the acid etching mineralizer) instead of the grilmar acid etchant of the control group.
The dentinal surfaces of the control group and the experimental group were observed by an electron microscope, and it was found that there was a significant white substance deposited on the dentinal surface or blocking the dentinal tubules in the experimental group.
The shear strength results before and after the cold and hot cycles of the control group and the experimental group are statistically analyzed by using an independent sample t test, and the LSD test is used for comparison among the groups, the test level of each analysis is α -0.05, and the difference has statistical significance when P is less than 0.05.
The shear strength results show that the shear strength of the experimental group is significantly greater than the control group, as shown in the following table:
Claims (5)
1. an acid etching mineralizer for increasing the adhesiveness of dentin is characterized in that a certain proportion of soluble fluoride salt is added into acid etching agent phosphoric acid.
2. An increased adhesion acid etching mineralizer for dentin according to claim 1, wherein the soluble fluoride salt is sodium fluoride.
3. An acid etching mineralizer for increasing the adhesiveness of dentin according to claim 1, wherein the acid etching agent phosphoric acid is 37% by mass; the soluble fluoride salt is added in a proportion of 0.5 to 2 g per 100ml of 37% phosphoric acid.
4. Use of an acid etching mineralizing agent for increasing the adhesiveness of dentin as claimed in any one of claims 1 to 3 as a treatment agent for acid etching mineralizing and further improving the adhesiveness before dentin adhesion.
5. The use according to claim 4, wherein sodium fluoride is used as a part of the treatment agent and is co-used with phosphoric acid on the dentin adhesion surface, and after conventional rinsing with water, the sodium fluoride is removed by acid etching and simultaneously fluoride is deposited on the dentin surface and blocks dentin tubules, thereby reducing the influence of liquid in the dentin tubules on adhesion, reducing the sensitivity of teeth to external stimuli, promoting the mineralization of dentin and increasing the adhesion and anti-aging performance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202010060940.5A CN111195207A (en) | 2020-01-19 | 2020-01-19 | Acid etching mineralizer for increasing adhesiveness of dentin |
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| CN202010060940.5A CN111195207A (en) | 2020-01-19 | 2020-01-19 | Acid etching mineralizer for increasing adhesiveness of dentin |
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| CN202010060940.5A Pending CN111195207A (en) | 2020-01-19 | 2020-01-19 | Acid etching mineralizer for increasing adhesiveness of dentin |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112494340A (en) * | 2020-11-02 | 2021-03-16 | 浙江大学 | Dental bonding pretreatment material and application |
| CN112494339A (en) * | 2020-11-02 | 2021-03-16 | 浙江大学 | Dental bonding pretreatment composition based on in-situ deposition of nano silver particles and application |
Citations (5)
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| US4770634A (en) * | 1986-06-11 | 1988-09-13 | Pellico Michael A | Method for treating teeth with foamable fluoride compositions |
| CN1720022A (en) * | 2002-12-13 | 2006-01-11 | 宝洁公司 | Method of enhancing fluoridation and mineralization of teeth |
| TW201121574A (en) * | 2009-12-24 | 2011-07-01 | Far Eastern New Century Corp | Dental acid etching gel composition and method of use thereof |
| CN103876945A (en) * | 2014-04-17 | 2014-06-25 | 厦门大学 | Dentinal-tubule sealing agent and preparation method thereof |
| WO2014201592A1 (en) * | 2013-06-20 | 2014-12-24 | 北京大学 | Dental prosthetic material and preparation method therefor |
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2020
- 2020-01-19 CN CN202010060940.5A patent/CN111195207A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4770634A (en) * | 1986-06-11 | 1988-09-13 | Pellico Michael A | Method for treating teeth with foamable fluoride compositions |
| CN1720022A (en) * | 2002-12-13 | 2006-01-11 | 宝洁公司 | Method of enhancing fluoridation and mineralization of teeth |
| TW201121574A (en) * | 2009-12-24 | 2011-07-01 | Far Eastern New Century Corp | Dental acid etching gel composition and method of use thereof |
| WO2014201592A1 (en) * | 2013-06-20 | 2014-12-24 | 北京大学 | Dental prosthetic material and preparation method therefor |
| CN103876945A (en) * | 2014-04-17 | 2014-06-25 | 厦门大学 | Dentinal-tubule sealing agent and preparation method thereof |
Non-Patent Citations (6)
| Title |
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| P.ALTINCI等: "Microtensile bond strength to phosphoric acid-etched dentin treated with NaF, KF and CaF2", 《INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES》 * |
| 普洁学习中心: "【牙医学堂】自酸蚀、全酸蚀，你懂其中的区别吗？", 《搜狐网》 * |
| 杜凤芝、熊均平、王新萍主编: "《口腔内科学》", 31 July 2015, 中国医药科技出版社 * |
| 杨宝学、张兰: "《实用临床药物学》", 31 July 2018, 中国医药科技出版社 * |
| 马嘉、张扬、洪玉华: "含不同浓度氟化钠的酸蚀液对托槽抗剪粘接强度的影响", 《华西口腔医学杂志》 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112494340A (en) * | 2020-11-02 | 2021-03-16 | 浙江大学 | Dental bonding pretreatment material and application |
| CN112494339A (en) * | 2020-11-02 | 2021-03-16 | 浙江大学 | Dental bonding pretreatment composition based on in-situ deposition of nano silver particles and application |
| CN112494339B (en) * | 2020-11-02 | 2021-08-20 | 浙江大学 | Dental bonding pretreatment composition based on in-situ deposition of nano silver particles and application |
| WO2022088518A1 (en) * | 2020-11-02 | 2022-05-05 | 浙江大学 | Dental bonding pretreatment material and use |
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Application publication date: 20200526 |