CN111184795A - Traditional Chinese medicine composition for treating cognitive function impairment, decoction based on traditional Chinese medicine composition and preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating cognitive function impairment, a decoction based on the traditional Chinese medicine composition and a preparation method of the traditional Chinese medicine composition, wherein the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 20-30 parts of calcined magnetite, 5-12 parts of fried spina date seed, 5-12 parts of gentian, 5-12 parts of radix bupleuri, 5-12 parts of radix rehmanniae recen, 1-5 parts of salvia miltiorrhiza and 1-5 parts of uncaria. The traditional Chinese medicine composition is used for treating cognitive function impairment, and is particularly remarkably improved in the aspects of improving speech working memory and executing inhibition. Can improve the psychotic symptoms, cognitive functions and negative symptoms of patients. The composition has a synergistic effect on the combined western medicines, and can reduce adverse reactions of the western medicines and the dosage of the western medicines.

Description

Traditional Chinese medicine composition for treating cognitive function impairment, decoction based on traditional Chinese medicine composition and preparation method

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, relates to a traditional Chinese medicine composition related to mental diseases, and particularly relates to a traditional Chinese medicine composition for treating cognitive function impairment, a decoction based on the traditional Chinese medicine composition and a preparation method of the decoction.

Background

Impairment of cognitive function is a central symptom of schizophrenia. Schizophrenia belongs to the most serious of various psychoses, the prevalence rate of Chinese population is about 1%, and the proportion of inpatients in the disease is close to 70%. Currently, little attention is paid to cognitive impairment in the treatment of schizophrenia, whether psychotherapy or drug therapy. The recovery of the cognitive function of the patient is just the key to the social return, normal work and learning. The treatment methods of cognitive function impairment which are known at present mainly comprise cognitive enhancing drugs, behavioral intervention and physical therapy. Wherein, the cognitive enhancing drugs are not uniform in academic conclusions about the treatment effect of cognitive impairment; in the other two methods, the therapeutic effect needs to be comprehensively evaluated.

The reason why the cognitive impairment is mainly manifested in the aspects of abstract thinking, memory, attention, alertness, visual space processing capacity, information integration, motor coordination and the like is that the schizophrenia patient still cannot be cured even if positive symptoms such as hallucinations, delusions and the like are well improved is that: most of the existing medicines have no treatment effect on cognitive function damage and partial negative symptoms, the cognitive function damage cannot be recovered, and the patient cannot be cured really. Therefore, the effective treatment of the cognitive function impairment of the schizophrenia patient can obviously improve the prognosis of the patient and reduce the burden of families and society.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention aims to provide a traditional Chinese medicine composition for treating cognitive function impairment, a decoction based on the traditional Chinese medicine composition and a preparation method of the decoction.

In order to achieve the purpose, the invention adopts the following technical scheme to realize the purpose:

the invention discloses a traditional Chinese medicine composition for treating cognitive function impairment, which comprises the following raw material medicines in parts by mass: 20-30 parts of calcined magnetite, 5-12 parts of fried spina date seed, 5-12 parts of gentian, 5-12 parts of radix bupleuri, 5-12 parts of radix rehmanniae recen, 1-5 parts of salvia miltiorrhiza and 1-5 parts of uncaria.

Preferably, the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 22-25 parts of calcined magnetite, 8-10 parts of fried spina date seed, 8-10 parts of gentian, 8-10 parts of radix bupleuri, 8-10 parts of radix rehmanniae recen, 2-4 parts of salvia miltiorrhiza and 2-4 parts of uncaria.

Further preferably, the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 24 parts of calcined magnetite, 9 parts of fried spina date seed, 9 parts of gentian, 9 parts of radix bupleuri, 9 parts of radix rehmanniae recen, 3 parts of salvia miltiorrhiza and 3 parts of uncaria.

Further preferably, the traditional Chinese medicine composition is used as a medicinal component, and auxiliary materials are added to prepare an oral preparation.

More preferably, the oral preparation is tablets, powder, pills, capsules, granules, decoction or oral liquid.

Still more preferably, the auxiliary materials comprise one or more of a stabilizer, a solubilizer, a lubricant and a disintegrating agent.

The invention also discloses a method for preparing a decoction by adopting the traditional Chinese medicine composition for treating cognitive function impairment, which comprises the following steps:

1) soaking 5-12 g of fried spina date seed, 5-12 g of gentian, 5-12 g of radix bupleuri, 5-12 g of radix rehmanniae, 1-5 g of salvia miltiorrhiza and 1-5 g of uncaria in water for 20-40 min, and taking out for later use;

2) boiling water, adding 20-30 g of calcined magnetite after the water is boiled, decocting for 5min, then adding the soaked medicine obtained in the step 1), decocting for 20-40 min with soft fire, pouring out part of decoction, adding water, continuously decocting for 20-40 min, pouring out the decoction again, and combining the two decoctions to obtain the decoction of which the total volume is 100 mL.

The invention also discloses a traditional Chinese medicine decoction for treating cognitive function impairment, which is prepared by adopting the decoction preparation method.

Preferably, the dosage of the Chinese medicinal decoction is 100mL for 1 day, and the dosage is 50mL respectively in the morning and evening twice a day.

Compared with the prior art, the invention has the following beneficial effects:

the traditional Chinese medicine composition for treating cognitive function damage breaks through the treatment of epilepsy in traditional Chinese medicine, attaches importance to positive symptoms such as hallucinations and delusions, and obviously improves negative symptoms and cognitive function damage. The traditional Chinese medicine composition mainly solves the problems that patients have obstacles in aspects of abstract thinking, memory, attention, alertness, visual space processing capacity, information integration, motor coordination and the like, screens out natural edible plant medicines with the functions of improving learning memory and improving execution inhibition for use as medicines, is matched with metal ions formed by quenching mineral medicines, is a practical prescription for clinical use, forms a medicine combination for effectively treating cognitive function damage, can reduce yang and relieve depression, and improves the cognition of the patients.

In the currently reported traditional Chinese medicine composition for treating cognitive function impairment, only reports of radix bupleuri, gentiana scabra bunge and radix salviae miltiorrhizae are inquired in related reports related to the invention, and the contents mainly aim at treating diseases related to organic change, such as cardiovascular and cerebrovascular diseases, vascular dementia, cognitive dysfunction, brain injury, neurodegenerative diseases and the like, wherein the cognitive function impairment highly related to negative symptoms in the mental disorders treated by the invention is in a different treatment range; moreover, the fat solubility of the reported medicinal components of the salvia miltiorrhiza is more, the difference of the medicinal components extracted by the decoction method is larger, and the medicinal components are far away from the use method, the dosage and the combined traditional Chinese medicinal materials of the bupleurum, the gentian and the salvia miltiorrhiza. The medical disciplines involved in the department of neurology have been reported, and no psychiatric discipline has been reported. The only thing to be understood is that the medicinal materials have a repairing effect on the cognitive function of organic lesions, but whether the medicinal materials have the repairing effect on the cognitive function in the aspect of mental disorder cannot be known at all, and the preparation method and the safety of the traditional Chinese medicine composition are firstly and completely researched in the aspect of the invention.

The traditional Chinese medicine composition decoction capable of treating mental disorder accompanied with cognitive function impairment is prepared by a simple and easy-to-operate method, negative symptoms can be obviously improved and the verbal working memory and execution capacity of patients can be improved by continuous oral administration for about 40 days, the effect is obvious, and the patients can quickly return to the society.

Drawings

FIG. 1 is a graph showing the effect of the Chinese medicinal composition on the dosage, blood concentration and drug action of the combined western medicine.

Detailed Description

In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

It should be noted that the terms "first," "second," and the like in the description and claims of the present invention and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the invention described herein are capable of operation in sequences other than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

The invention is described in further detail below with reference to the accompanying drawings:

1. examples of the Chinese medicinal composition

Example 1

Preparing raw material medicines in parts by mass:

24g of calcined magnet, 9g of fried spina date seed, 9g of gentian, 9g of radix bupleuri, 9g of radix rehmanniae recen, 3g of salvia miltiorrhiza and 3g of uncaria. Soaking the above materials except calcined Magnetitum in water for 30 min. Decocting in water, adding calcined Magnetitum for 5min after boiling, adding the rest soaking materials, decocting with slow fire for 30min, pouring out part of decoction, adding water, decocting for 30min, pouring out, and mixing. The water adding amount is controlled in the two times of decoction, and about 100mL of the decoction is poured out by mixing, which is the daily dosage of 1 day. The preparation is taken 1 time in the morning and at night, 50mL each time.

Example 2

Preparing raw material medicines in parts by mass:

20g of calcined magnetite, 10g of fried spina date seed, 12g of gentian, 5g of radix bupleuri, 12g of radix rehmanniae, 3g of salvia miltiorrhiza and 1g of uncaria.

Soaking the above materials except calcined Magnetitum in water for 25 min. Decocting in water, adding calcined Magnetitum for 5min after boiling, adding the rest soaking materials, decocting with slow fire for 20min, pouring out part of decoction, adding water, decocting for 40min, and mixing. The water adding amount is controlled in the two times of decoction, and about 100mL of the decoction is poured out by mixing, which is the daily dosage of 1 day. The preparation is taken 1 time in the morning and at night, 50mL each time.

Example 3

Preparing raw material medicines in parts by mass:

25g of calcined magnet, 5g of fried spina date seed, 10g of gentian, 8g of radix bupleuri, 10g of radix rehmanniae recen, 1g of salvia miltiorrhiza and 4g of uncaria.

Soaking the above materials except calcined Magnetitum in water for 40 min. Decocting in water, adding calcined Magnetitum for 5min after boiling, adding the rest soaking materials, decocting with slow fire for 30min, pouring out part of decoction, adding water, decocting for 20min, pouring out, and mixing. The water adding amount is controlled in the two times of decoction, and about 100mL of the decoction is poured out by mixing, which is the daily dosage of 1 day. The preparation is taken 1 time in the morning and at night, 50mL each time.

Example 4

Preparing raw material medicines in parts by mass:

28g of calcined magnetite, 12g of fried spina date seed, 5g of gentian, 12g of radix bupleuri, 5g of radix rehmanniae recen, 5g of salvia miltiorrhiza and 5g of uncaria.

Soaking the above materials except calcined Magnetitum in water for 20 min. Decocting in water, adding calcined Magnetitum for 5min after boiling, adding the rest soaking materials, decocting with slow fire for 40min, pouring out part of decoction, adding water, decocting for 20min, pouring out, and mixing. The water adding amount is controlled in the two times of decoction, and about 100mL of the decoction is poured out by mixing, which is the daily dosage of 1 day. The preparation is taken 1 time in the morning and at night, 50mL each time.

In addition, the flavor can be added or reduced according to the actual situation for adjustment: can be prepared from any Chinese medicinal composition containing calcined magnetite, stir-fried spina date seed, gentian, uncaria, radix bupleuri and the like, and added or reduced flavors, preferably decoction of all the given Chinese medicinal materials of the raw materials, and can be obtained by a decoction method.

2. Therapeutic effect on cognitive impairment

2.1 study object

Approved by ethical committee of the centers for mental health in west amp, 30 male patients with schizophrenia who were hospitalized in the centers for mental health in west amp, 4 months to 2019 month in 2018 were included in the study, and the inclusion criteria, exclusion criteria and withdrawal criteria were as follows.

1) Group entry criteria

① Male patients with age of 18-65 years;

② meets the diagnostic criteria for schizophrenia in ICD-10 and DSM-V;

③ obtain informed consent of the patient or his legal guardian.

2) Exclusion criteria

Evidence suggests the presence of clinically significant, severe, uncontrolled somatic disease;

with other mental disorders, mental retardation or personality disorders;

refractory schizophrenia;

a previous history of malignant syndrome with antipsychotics;

those who have received no-tic electroconvulsive therapy in the last 6 months;

the prior history of alcohol, drug dependence and abuse;

have a significant risk of suicidal or uncontrolled violent impulsion;

tests related to cognitive dysfunction were performed in the last 6 months;

those with obvious visual and auditory disorders.

3) Group withdrawal standard

Patients have serious and uncontrollable adverse reactions and need to use other medicines prohibited for use;

the patient does not regularly complete various tests as required;

the doctor considers that the patient needs to quit the test;

patients privately use medications that doctors prohibit their use;

patients complicated by other severe somatic diseases, and continuing the test will have adverse effects on the patients;

the patient actively requests to exit the trial.

2.2 drug treatment and titration methods

All patients brought into the study are randomly divided into a control group and a study group, wherein the two groups take quetiapine fumarate tablets (Vivid, specification 100 mg/tablet, Hunan Dongting pharmaceutical industry, Inc.) orally in the whole treatment process, the control group singly uses quetiapine for treatment, the study group uses quetiapine and drug combination, the drugs are decocted uniformly in a decoction chamber of a hospital, and the decocted drug liquid is vacuum-packaged, wherein each bag is 200 mL. The drug titration is strictly carried out according to the following manner, 100mg of quetiapine on the 1 st day, 200mg on the 2 nd day, 300mg on the 3 rd day and 400mg on the 8 th day, then the dosage of the quetiapine is adjusted according to the scale score and the monitoring of the concentration of the quetiapine therapeutic drug until the blood concentration enters a treatment window, and the research group starts to give the oral traditional Chinese medicine composition decoction at the 12 th day, 1 bag of the oral traditional Chinese medicine composition decoction is taken every time, 2 times a day, and the composition decoction is continuously taken for 2 months.

2.3 Scale evaluation

Disease severity scale assessments were performed using the positive and negative symptoms scale (PANSS). The composition of the PANSS scale included 7 positive symptoms, 7 negative symptoms, and 16 general psychopathological symptoms, for a total of 30 evaluation items, of which 3 items used to assess the risk of challenge were not included in the total score. The 30 entries were made according to a factor analysis, as the treatment effect of cognitive impairment was mainly examined, including: positive factor, negative factor, cognitive factor, exciting factor anxiety depression factor. Assessments were performed on baseline, 1, 2, 3, 4, 5, 6, 7, and 8 weekends, respectively, to record patient changes during baseline and cohort treatments, on a PANSS scale reduction scale with four points: the recovery rate is not less than 75%; 50% -74% are significantly effective; 25% -49% are effective; less than 25% is treatment ineffective. The score reduction is (pre-treatment score-post-treatment score)/pre-treatment score × 100%.

2.4 assessment of cognitive function

Cognitive function assessments were performed 1 time before group treatment and 2 months after treatment. Computerized complete cognitive function Assessment (ACCT) was used: the five aspects of cognitive function of the tested patients were evaluated. The method comprises the following steps: processing speed: 3 items of connection test, symbol coding and symbol retrieval; note that: run test 1 continuously; working and memory of speech: number breadth, number sequence 2 item; visual memory: the spatial extent and the spatial extent are inverted 2 items; performing inhibition: stroop words, Stroop color words, Stroop word color 3 items.

The ACCT scoring system adopts a five-grade scoring method for evaluating the cognitive function, wherein more than 50 points and above indicate normal, 40-50 points are slightly damaged, 30-40 points are moderately damaged, 20-30 points are moderately and severely damaged, and less than 20 points are severely damaged.

2.5 improving Effect of the Chinese medicinal composition on the mental symptom factor in the treatment of cognitive impairment

As shown in table 1, after 8 weeks of treatment, the factors of the herbal composition group and the control group were significantly improved (P <0.001) compared to those before treatment. Compared with the groups, the improvement of the negative factors and the cognitive factors related to cognitive impairment in the traditional Chinese medicine composition group at the end of 8 weeks is obviously better than that in the control group (P < 0.05).

TABLE 1 mean pre-treatment and 8-week-end score for psychiatric symptom factors

Note: the vs control group corresponds to the time point,^*P<0.05，^**P<0.01

after the reduction rate calculation is carried out, the mean reduction rate of each factor of the treatment group of the traditional Chinese medicine composition at 8 weekends is higher than that of the control group (P >0.05), as shown in table 2, the improvement of the cognitive factors related to cognitive impairment and the mean reduction rate of negative factors at 8 weekends is more remarkable by the negative factors, the mean reduction rate is 52.55%, which is 11.26% higher than that of the control group, and the result trend is the same as that of table 1; while the positive symptoms are exciting factors, the mean value of the treatment reduction rate of the traditional Chinese medicine composition is improved by 12.13%. The mean value of the reduction ratio of each factor in the traditional Chinese medicine composition group is as follows from high to low: excitant > positive factor > negative factor > anxiolytic depressive factor > cognitive factor.

TABLE 2 mean reduction of psychiatric symptom factor 8 weekend treatment (100%)

Compared with the improvement of the traditional Chinese medicine composition treatment group patients in each field of cognitive functions before and after treatment, the scoring result is shown in table 3. The Chinese medicinal composition has significant improvement on three tests of numerical sequences, Stroop color words and Stroop color in ACCT evaluation indexes before and after 8 weeks of treatment, and has statistical difference (P <0.05), wherein the Stroop color words and Stroop color words in the execution inhibition have particularly significant improvement effect (P < 0.01). The traditional Chinese medicine composition has obvious effect of improving working memory and executive power of speech in the cognitive function impairment treatment process.

Table 3 assessment of cognitive function indices pre-treatment and post-8 weeks (n-9)

Note: before vs treatment,. P <0.05,. P <0.01

3. Safety assessment in treatment of traditional Chinese medicine composition

3.1 laboratory examinations

The patient is subjected to electrocardiographic examination on the day of admission, and blood is collected on an empty stomach in the 2 nd morning to detect various indexes of liver function, kidney function, blood fat, electrolyte, myocardial zymogram, empty stomach blood sugar and prolactin. The indexes are reviewed at 4 and 8 weeks during the treatment.

Also, adverse event scale assessments were performed using the adverse event scale (TESS), which included common symptoms and signs, and partial laboratory examinations using a 4-grade severity assessment method.

3.2 laboratory test results analysis

As shown in Table 4, the Chinese medicinal composition in the using process and the laboratory test result of the control group have cases that the project indexes of liver function, blood fat and creatinase exceed the critical high values of the reference values, but the numerical values have no clinical significance. Most project index abnormalities occur at the end of 4 weeks, and indexes return to normal at the end of 8 weeks, which indicates that the project indexes are transient. The only concern is that in the blood lipid program, 2 people in the treatment group of the traditional Chinese medicine composition have cholesterol abnormality, 1 person in the control group has cholesterol abnormality, and 2 people have triglyceride abnormality. Hypertriglyceridemia is associated with negative factors, anxiolytic and depressive factors, and not high cholesterol.

TABLE 4 summary of laboratory examinations over critical high value counts

3.3 adverse reaction/event recording results analysis

As shown in table 5, the patient experienced headache when first taking quetiapine medication, but no longer experienced as the tolerance increased. Adverse reactions such as constipation, lethargy, tachycardia and the like mainly occur before the application of the traditional Chinese medicine composition, namely before the 12 th day. Therefore, if the summary adverse reaction is related to the medicament, the adverse reaction is mainly caused by quetiapine, no adverse reaction record is found after the traditional Chinese medicine composition is used, and the adverse reaction does not occur after the control group is used for 2 weeks along with the prolonging of the use time and the effective pharmaceutical intervention.

TABLE 5 summary of adverse reaction/event occurrence and score results

4. Drug concentration and therapeutic efficacy

4.1 combining the results of the concentration measurements of the Western medicines

As shown in Table 6, when the combination of the herbal decoctions of the Chinese medicinal materials was started in the group on day 12, the dose of the group was significantly lower from week 3 to week 6 than that of the control group, but the blood level of the combined western medicine quetiapine was not different between the two groups (P > 0.05). The traditional Chinese medicine composition can reduce the dosage of the combined western medicines and improve the blood concentration of the combined western medicines.

TABLE 6 Combined Western medicine quetiapine dosage and blood concentration

Note: the control group of vs was prepared by the following method,^*P<0.05

4.2 Overall curative Effect of the Chinese medicinal composition

Under the condition of no difference of blood concentration, the traditional Chinese medicine composition group shows better treatment effect, has effects on various psychopathic symptoms and cognitive functions in the previous 2.5 and 2.6, and is better than the control group in the aspect of overall curative effect, as shown in figure 1. Under the condition of low-concentration combined western medicines, the reduction rate of the traditional Chinese medicine composition after 4 weeks exceeds that of a control group, which can show that the traditional Chinese medicine composition has a synergistic effect on the combined western medicines after two weeks of use.

By combining the content of 4.1 and the histogram in fig. 1, the traditional Chinese medicine composition can not only reduce the dosage of the combined western medicine quetiapine, but also control the blood concentration within a safe range (the blood concentration is lower by nearly 100ng/mL compared with the blood concentration of a control group, and the upper limit of the treatment window is 500ng/mL), and can improve the treatment effect. By combining with the '3 safety evaluation in treatment of the traditional Chinese medicine composition', the traditional Chinese medicine composition also has the function of reducing adverse reactions when being used together with western medicines. The advantage effect is reflected in the improvement effect of the traditional Chinese medicine composition on the cognitive function in the cognitive impairment treatment 2.6, wherein the traditional Chinese medicine composition has particularly obvious effect on improving the working memory and the executive power of the speech in the cognitive impairment treatment process. Finally, the traditional Chinese medicine composition has the obvious improvement effect on negative factors.

5. Specific use examples are given below:

typical case is one, zhuo, man, age 41.

The patient is admitted with a complaint of "make sure you please for 6 years". The main symptoms are: auditory hallucination, delusion, loose thinking, diffuse association, apathy emotion, dismissal emotion withdrawal, laziness, poor hygiene, self-speaking, and lonely; and (3) mental examination: walking into a ward, making consciousness please, contact is passive, life needs to be supervised and urged, examination is cooperative, and orientation force is normal; questions can be answered, questions about the lack of interest can be answered, thought association is diffused, and auditory hallucinations and pernicious delusions can be examined; inattention; memory decline; apathy, flat expression, hypovolemia, bizarre behavior, often to air 35881, and also to the cases of expletive, visceral, sometimes self-speaking and no self-knowledge. PANSS scores 102 points at admission (basal score 30 points, total asymptomatic score 30). The negative factors and cognitive factors of the previous 2 weeks of patients were almost unchanged by the combination of quetiapine and amisulpride. The treatment is carried out by using the decoction of the traditional Chinese medicine composition from the end of 2 weeks until the 8 th week. The patient has a long course of disease, the patient has no self-cognition when being admitted, the cognitive function can not be repaired by combining the two western medicines, and the cognitive function of the traditional Chinese medicine composition decoction is recovered by 58.8 percent (the cognitive factor reduction rate in the PANSS scale) after the traditional Chinese medicine composition decoction is continuously treated for 6 weeks. Mental symptoms of the patient are obviously improved when the patient is discharged, and although partial auditory hallucinations still exist, the cognitive function is recovered and is incomplete.

Classic case two, Wangzhi, female, age 17.

The patients are hospitalized in children department of our hospital and diagnosed as schizophrenia due to the patient's onset and hospitalization of the children who are less than 18 years old, then are treated by quetiapine, and the patients are discharged and followed by clinic visits. The disease condition is aggravated in 10 months in 2018 half a year later, the outpatient treatment is carried out, the blood concentration is found to be unstable when the blood concentration is checked, the effective treatment range cannot be maintained, then the patient is admitted, the medicine is adjusted for many times, the effect is still poor, and the patient only needs to continue to use quetiapine for treatment. The traditional Chinese medicine decoction disclosed by the invention is used for assisting quetiapine in treatment in 8 months in 2019, patients take the decoction continuously for 2 months, the mental symptoms are obviously improved, the cognitive function is improved, and the decoction can be normally communicated with people. Only the quetiapine single-drug therapy is taken after the treatment, the follow-up visit is kept all the time, and the state is stable.

Classic case three. Wangzhi, male, age 36

Admission conditions: the patient complains about receiving and hospitalizing in 2018 in 11, 8 days as "sniff sound by air, make more suspicion for more than 1 year and make more 3 days". The main symptoms are: auditory hallucinations, delusions of harmful, delusions of relationship, tracked and monitored sensations, insomnia, bizarre behavior; and (3) mental examination: walking into the ward, making the appearance incomplete, making consciousness please, contact showing passivity, requiring supervision and urging in life, checking cooperation, normal orientation force, answering questions, being more critical, and checking auditory hallucinations, pernicious delusion, paradoxical delusion, and tracked and monitored feelings; inattention; the emotion is stable, the expression is flat, and the emotional response is harmonious with the surrounding environment; the behavior is strange, the head is knocked down, kneels down, and the user does not sleep all night; the self-learning ability is insufficient. No positive signs were found in the physical examination. Admission diagnosis: schizophrenia. The paness score at admission was 103 points (basal score 30 points, total asymptomatic score 30), and the results of the cognitive function test at admission were: the patient has severely impaired cognitive function, severely impaired cognitive function in the aspects of inhibition, attention and speech work and memory, moderately reduced cognitive function in the aspect of visual memory, and severely impaired cognitive function in the aspect of processing speed. The treatment is carried out by orally taking quetiapine and adding the decoction of the traditional Chinese medicine composition on the 10 th day. After more than 40 days of treatment by the decoction of the traditional Chinese medicine composition, the mental symptoms of patients basically disappear, the mood is stable, and the self-learning ability is partially recovered. PANSS score was 51 (score reduction 71.23%), and the cognitive function retest results were: the overall cognitive function of the patient is evaluated as mild-moderate impairment, the cognitive function improvement in the processing speed is most obviously mild impairment, and the inhibition improvement is carried out to be second obvious impairment; note that cognitive function in speech work and memory becomes moderately impaired, and cognitive function in visual memory is not significantly improved. Discharge from the hospital according to the requirements of family members. And in the follow-up visit in the later period, the patient keeps taking western medicines after being discharged from the hospital and does not enter the hospital for the second time.

One in four typical cases, male, age 28

Admission conditions: the patient has no obvious phenomena of suspicion, multiple concerns, recklessness and the like caused by emerging reasons 1 year ago. Recently, as the symptoms of patients are aggravated and phenomena of unstable emotion, irritability, injury to other people, object smashing, even self-disability and the like are accompanied, the patients cannot be managed by families, and the patients are sent to our hospital to be treated by the assistance of 110 and 120 workers at present, and the outpatient and emergency treatment are in a state of' 1. excitation; 2. organic mental disorders are to be excluded; 3. the head trauma is admitted to the hospital. Since the disease comes, people can eat and defecate, the sleep is poor, and the self-learning ability is not good. Admission was admitted at 12 days 8 months, admission diagnosis: schizophrenia was immediately treated with quetiapine. PANSS scores at admission were 99 points (basal 30 points, total asymptomatic 30 points). The decoction of the traditional Chinese medicine composition is used for treatment by matching with quetiapine in 3 days after 9 months until 29 days after 10 months, and the single-medicine treatment of the quetiapine is continued. The disease condition of a patient treated by the Chinese medicinal composition decoction is obviously improved after 2 months, the psychotic symptoms are obviously improved, and the sleep is good; the traditional Chinese medicine composition decoction has the advantages of stable mood, obvious improvement of psychotic symptoms, passive cooperation of treatment examination, partial recovery of self-cognition, PANSS score of 40 (the reduction rate of 85.50%) after treatment, 90.00% of negative factor reduction rate and 66.67% of cognitive factor reduction rate of the patient compared with the negative factor at the time of admission, and only 5 of the 16 symptom items of the above factors have symptom residues and are the mildest. The follow-up visit in the later period shows that the patients are in good condition.

Typical cases are five, high, male, 25 years old.

The phenomena that the patient is suspicious and worried, the monitored feeling is tracked, the emotion is low and the like are found by the family of the patient in 2017 and 10 months. In the next half year of 2018, the condition becomes more serious, the parents of the patients send the patients to our hospital for treatment, and the outpatient clinic adopts schizophrenia to receive and admit the patients. Treatment was initiated with quetiapine. At admission, PANSS scores 130 points (basal 30 points, total asymptomatic 30 points), and the disease condition was severe. The cognitive function impairment is as follows: the traditional Chinese medicine composition can inhibit severe damage, moderate and severe damage of processing speed, moderate damage of attention and speech work memory and mild damage of visual memory. When the quetiapine is added to the steady blood concentration, the decoction of the traditional Chinese medicine composition is used for treatment in a matching way for 8 weeks. The cognitive function improvement except attention is not obvious after 8 weeks, the cognitive function is improved by one grade level, and the visual memory is recovered to be normal. The PANSS score is 40 (the reduction rate is 86.00%) after the decoction of the traditional Chinese medicine composition is treated, the patient has obviously improved illness, stable mood and obviously improved psychotic symptoms, and negative factors and cognitive factors are respectively improved by 90% and 71.4%.

In conclusion, the traditional Chinese medicine composition is used for treating cognitive function impairment, and particularly has remarkable improvement in the aspects of improving speech working memory and execution inhibition. Can improve the psychotic symptoms, cognitive functions and negative symptoms of patients. The composition has a synergistic effect on the combined western medicines, and can reduce adverse reactions of the western medicines and the dosage of the western medicines.

The above-mentioned contents are only for illustrating the technical idea of the present invention, and the protection scope of the present invention is not limited thereby, and any modification made on the basis of the technical idea of the present invention falls within the protection scope of the claims of the present invention.

Claims (9)

1. A traditional Chinese medicine composition for treating cognitive impairment is characterized by comprising the following raw material medicines in parts by mass: 20-30 parts of calcined magnetite, 5-12 parts of fried spina date seed, 5-12 parts of gentian, 5-12 parts of radix bupleuri, 5-12 parts of radix rehmanniae recen, 1-5 parts of salvia miltiorrhiza and 1-5 parts of uncaria.

2. The traditional Chinese medicine composition for treating cognitive impairment according to claim 1, which comprises the following raw material medicines in parts by mass: 22-25 parts of calcined magnetite, 8-10 parts of fried spina date seed, 8-10 parts of gentian, 8-10 parts of radix bupleuri, 8-10 parts of radix rehmanniae recen, 2-4 parts of salvia miltiorrhiza and 2-4 parts of uncaria.

3. The traditional Chinese medicine composition for treating cognitive impairment according to claim 2, which comprises the following raw material medicines in parts by mass: 24 parts of calcined magnetite, 9 parts of fried spina date seed, 9 parts of gentian, 9 parts of radix bupleuri, 9 parts of radix rehmanniae recen, 3 parts of salvia miltiorrhiza and 3 parts of uncaria.

4. The traditional Chinese medicine composition for treating cognitive impairment according to any one of claims 1 to 3, wherein the traditional Chinese medicine composition is used as a medicinal component, and is added with an auxiliary material to prepare an oral preparation.

5. The traditional Chinese medicine composition for treating cognitive impairment according to claim 4, wherein the oral preparation is a tablet, powder, pill, capsule, granule, decoction or oral liquid.

6. The traditional Chinese medicine composition for treating cognitive impairment according to claim 4, wherein the auxiliary materials comprise one or more of a stabilizer, a solubilizer, a lubricant and a disintegrant.

7. A method for preparing a decoction by using the traditional Chinese medicine composition for treating cognitive impairment of any one of claims 1 to 3, which comprises the following steps:

1) soaking 5-12 g of fried spina date seed, 5-12 g of gentian, 5-12 g of radix bupleuri, 5-12 g of radix rehmanniae, 1-5 g of salvia miltiorrhiza and 1-5 g of uncaria in water for 20-40 min, and taking out for later use;

2) boiling water, adding 20-30 g of calcined magnetite after the water is boiled, decocting for 5min, then adding the soaked medicine obtained in the step 1), decocting for 20-40 min with soft fire, pouring out part of decoction, adding water, continuously decocting for 20-40 min, pouring out the decoction again, and combining the two decoctions to obtain the decoction of which the total volume is 100 mL.

8. A Chinese medicinal decoction for treating cognitive impairment prepared by the method for preparing decoction according to claim 7.

9. The herbal decoction for treating cognitive impairment of claim 8, wherein 1 daily dose of the herbal decoction is 100mL, twice a day, 50mL in the morning and evening.

Images