CN111170256B - Ampoule washing, moistening, filling and sealing integrated device - Google Patents
Ampoule washing, moistening, filling and sealing integrated device Download PDFInfo
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- CN111170256B CN111170256B CN202010042155.7A CN202010042155A CN111170256B CN 111170256 B CN111170256 B CN 111170256B CN 202010042155 A CN202010042155 A CN 202010042155A CN 111170256 B CN111170256 B CN 111170256B
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- pipe
- moistening
- pressure plate
- rotary
- washing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
- B67C7/0006—Conveying; Synchronising
- B67C7/004—Conveying; Synchronising the containers travelling along a circular path
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
- B67C7/0073—Sterilising, aseptic filling and closing
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
- B67C7/0006—Conveying; Synchronising
- B67C2007/006—Devices particularly adapted for container filling
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
- B67C7/0006—Conveying; Synchronising
- B67C2007/0066—Devices particularly adapted for container closing
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- Filling Of Jars Or Cans And Processes For Cleaning And Sealing Jars (AREA)
- Basic Packing Technique (AREA)
Abstract
The invention discloses an ampoule bottle washing, moistening and encapsulating integrated device which comprises a host machine shell, a fixed disc, a rotary disc driving motor, a stepping motor lead screw sliding table, a washing, moistening and encapsulating integrated system and a rotary melt-sealing system, wherein the washing, moistening and encapsulating integrated system and the rotary melt-sealing system are sequentially arranged along the rotation direction of the rotary disc; the fixed disk is fixed on the host machine shell by a support, the rotary disk is positioned above the fixed disk, a self-adaptive clamping mechanism is arranged along the circumferential direction of the rotary disk, and the ampoule bottle is centered and fixed by the self-adaptive clamping mechanism; the washing, moistening and irrigating integrated system comprises a washing, moistening and irrigating lifting arm, and the washing, moistening and irrigating lifting arm is sequentially provided with a cleaning mechanism, a pre-moistening mechanism and a filling mechanism along the rotating direction of the turntable; the rotary sealing system comprises a rotating mechanism and a sealing mechanism. The invention combines the washing and the moistening, and can be used for protecting gas during filling; the synchronous operation of ampoule bottles with different specifications is realized by adopting a self-adaptive clamping mechanism to be matched with a flame-throwing port lifting sensor; the rotary melting sealing of the ampoule bottle is realized by adopting negative pressure adsorption, and the hemisphere melting sealing is realized without waste materials.
Description
Technical Field
The invention relates to an ampoule bottle washing, moistening and filling and sealing integrated device, in particular to an ampoule bottle washing, moistening and filling and sealing integrated device suitable for laboratories.
Background
The volume of the ampoule bottle is generally 1-25 mL, the ampoule bottle is widely applied to containing injection preparations and high-purity chemicals which must be isolated from air, the advantages of the ampoule bottle completely meet the requirements of laboratories, and standard products, experimental capability test samples, sample retention samples and the like in some laboratories are required.
The ampoule bottle is cleaned and dried before filling, then a certain amount of liquid medicament is filled into the ampoule bottle, and sealing is carried out after filling. The automatic ampoule bottle packaging equipment in the market is batched and continuous, is suitable for large pharmaceutical factories and enterprises with large packaging amount, occupies large area, has high cost, and can not be borne by all laboratories. The existing automatic equipment can only be debugged for the ampoule bottles of a certain specification after debugging is finished, and the existing automatic equipment needs to be debugged again when replacing ampoule bottles of other specifications. In addition, small ampoule packaging hardware has only provided a flame of sealing in the market, other operations are by artifical rotatory ampoule like the even temperature of bottleneck, the bottleneck shaping also relies on artifical judgement glass to be heated the temperature after adopt the instrument to press from both sides and pull out, this a series of actions both need equipment stability and need the cooperation completion of artificial experience and proficiency, but also can not guarantee that the time of being heated and the temperature of every ampoule are the same, probably produce the loss to the encapsulation sample, there is considerable influence to the accuracy of later stage experimental data.
Disclosure of Invention
The invention aims to provide an ampoule bottle washing, moistening and encapsulating integrated device aiming at the defects in the prior art.
The purpose of the invention is realized by the following technical scheme:
the utility model provides an ampoule washes moist embedment integrated device, includes host computer casing 1, fixed disk 24, carousel 11, carousel driving motor 6, along 11 direction of rotation of carousel set gradually wash moist irritate integrative system and rotatory melt-seal system, be used for respectively the installation wash moist irritate system, rotatory melt-seal system 2 individual step motor lead screw slip table 2.
The fixed disc 24 is fixed on the host machine shell 1 by a pillar; the rotary table 11 is positioned above the fixed disc 24, a plurality of self-adaptive clamping mechanisms 10 for placing the ampoule bottles 9 are arranged along the circumferential direction of the rotary table 11, and the ampoule bottles are centered and fixed by the self-adaptive clamping mechanisms 10 and supported by the fixed disc 24; the turntable driving motor 6 drives the turntable 11 to rotate, and the ampoule bottle is driven to slide on the fixed disk 24.
The washing, moistening and irrigating integrated system is positioned above the turntable 11 and comprises an arc-shaped washing, moistening and irrigating lifting arm 8, the washing, moistening and irrigating lifting arm 8 is driven by a stepping motor lead screw sliding table 2 to lift, and the washing, moistening and irrigating lifting arm 8 is sequentially provided with a cleaning mechanism, a pre-moistening mechanism and a filling mechanism or a cleaning mechanism and a filling mechanism along the rotation direction of the turntable 11; the cleaning mechanism/pre-wetting mechanism comprises a lifting arm fixing piece 15, a pipette 16 and a liquid injection pipe 21, wherein one end of the lifting arm fixing piece 15 is fixed by a washing and wetting irrigation lifting arm 8, the other end of the lifting arm fixing piece 15 radially extends to the position above the self-adaptive clamping mechanism 10, the pipette 16 is fixed by the lifting arm fixing piece 15, the bottom end of the pipette 16 can extend into an ampoule bottle and approach to the bottom of the ampoule bottle, the top end of the pipette 16 is connected with a negative pressure bottle, the liquid injection pipe 21 is sleeved outside the pipette 16 to enable the liquid injection pipe 21 to slide up and down along the pipette 16, a pressure plate 18 is arranged outside the liquid injection pipe 21, a soft material sealing gasket 19 is arranged at the bottom end of the pressure plate 18, and a gap is left between the liquid injection; the lower end of the liquid injection pipe 21 extends out of the pressure plate 18 and is conical, and a plurality of liquid injection ports 22 are formed in the conical end of the liquid injection pipe 21; the liquid injection pipe 21 is provided with a liquid inlet pipe 20 vertical to the liquid injection pipe, the liquid inlet pipe 20 penetrates through the pressure plate 18 to enable the liquid injection pipe 21 and the pressure plate 18 to form a whole, the liquid inlet pipe 20 is connected with a storage tank filled with cleaning liquid or liquid medicine through a liquid transfer pump, during cleaning/prewetting, the lifting arm of the cleaning/prewetting irrigation tank descends, the liquid suction pipe 16 extends into the ampoule bottle to be close to the bottom of the ampoule bottle, the ampoule bottle opening is pressed by the flexible material sealing gasket 19, the cleaning liquid or the liquid medicine is injected from the liquid injection opening 21 to the periphery to enable the ampoule bottle to be completely stained with the solution, the solution is sucked out; filling mechanism include lifing arm mounting 15, liquid feeding pipe 36 fixed and extend the self-adaptation fixture top by lifing arm mounting 15, in liquid feeding pipe 36 bottom can stretch into the ampoule, liquid feeding pipe top links to each other with the storage tank that is equipped with the liquid medicine through the measuring pump liquid feeding pipe 36 overcoat be equipped with pressure disk 18 and make pressure disk 18 can follow liquid feeding pipe 36 and slide from top to bottom, pressure disk 18 bottom is equipped with the sealed 19 of soft material, during the filling, directly use imbibition measuring pump pipe connector ration to add the liquid medicine.
The rotary sealing system comprises a rotating mechanism and a sealing mechanism; the rotating mechanism comprises a soft rotating sucker 25, a rotating shaft 31, a motor shaft 32 and a rotating fusion sealing driving motor 7, the soft rotating sucker 25 is fixed at the top end of the rotating shaft 31, the rotating shaft 31 is connected with the rotating fusion sealing driving motor 7 through the motor shaft 32, an annular sleeve 28 is sleeved on the outer sides of the soft rotating sucker 25 and the rotating shaft 31, and the upper end of the annular sleeve 28 is embedded into a fixed disc 24 to realize fixation; an annular vent groove 34 is arranged along the outer wall of the rotating shaft 31, and sealing rings 29 are respectively arranged above and below the vent groove 34; an air suction hole 27 is arranged along the axes of the soft rotary sucker 25 and the rotating shaft 31, the air suction hole 27 is communicated with the vent groove 34 through an inner radial vent hole 30 of the rotating shaft 31, an air suction pipe 26 is arranged on the side wall of the annular sleeve 28 corresponding to the vent groove 34, and the air suction pipe 26 is connected with a negative pressure device; the melt-sealing mechanism comprises a fire-jet lifting arm 3, a fire-jet pipe fixing piece 40 and at least 1L-shaped fire-jet pipe 5, the fire-jet lifting arm 3 is driven by a stepping motor lead screw sliding table 2 to lift, the fire-jet pipe fixing piece 40 is fixed on the fire-jet lifting arm 3, the fire-jet pipe 5 is fixed on the fire-jet pipe fixing piece 40 by an adjusting nut 4, after the ampoule bottle is filled with liquid medicine at the filling mechanism, the ampoule bottle is driven by a rotary table 11 to rotate to a rotary melt-sealing system, a negative pressure device is started, a soft rotary sucker 25 sucks the bottom of the ampoule bottle, a rotary melt-sealing driving motor 7 rotates to drive the ampoule bottle to rotate, and the melt-sealing mechanism burns and melts the bottle mouth to form hemispherical melt-sealing; after the sealing is finished, the negative pressure is released, and the ampoule bottle is separated from the soft rotary sucker 25.
The fixed disc 24 is in a circular ring shape; the fixing plate 24 is fixed on the host machine shell 1 by at least 3 pillars along the circumferential direction.
The rotary disc 11 is disc-shaped.
Self-adaptation fixture 10 including the ampoule hole site 12 that runs through carousel 11, evenly be equipped with 3 at least slider grooves 13 along the radial of ampoule hole site on carousel 11, be equipped with slider 14 in the slider groove 13, be equipped with the spring between the slider 14 one end far away apart from ampoule hole site centre of a circle and the slider groove, ampoule 9 is put into ampoule hole site 12, under the spring action, press from both sides tightly by the slider one end near the ampoule hole site centre of a circle and realize centering fixed.
Preferably, the lower end of the slider groove 13 does not penetrate.
Preferably, in order to prevent the slider 14 from falling out of the slider groove 13, two side walls of the slider groove 13 are respectively provided with a radial limiting groove which is not communicated with the side wall of the ampoule bottle hole site 12, two side walls of the slider 14 are respectively provided with a limiting strip corresponding to the limiting groove, the length of the limiting strip is shorter than that of the limiting groove, and the limiting strip is arranged in the limiting groove.
The installation of the spring in the adaptive clamping mechanism 10 is a conventional method, the spring can be directly arranged in the slider groove, the slider and the slider groove can also be provided with installation rings, the two ends of the spring are fixed by the installation rings, and the two ends of the spring can also be respectively fixed on the slider and the slider groove through screws.
Preferably, the cleaning mechanism/pre-moistening mechanism further comprises a pressure plate lifting limiting block 23, the pressure plate lifting limiting block 23 is sleeved outside the pipette 16, a spring 17 is sleeved outside the pressure plate lifting limiting block 23, the upper end of the spring 17 is embedded into the pressure plate lifting limiting block 23, and the lower end of the spring 17 is fixed to the top end of the pressure plate 18; the pressure plate lifting limiting block 23 and the pressure plate 18 are spaced for spring buffering.
Preferably, when sensitive (easy to oxidize and easy to change) liquid medicine is filled, the inflation tube 37 is sleeved between the liquid feeding tube 36 and the pressure plate so that the inflation tube 37 can slide up and down along the liquid feeding tube 36, a gap is reserved between the inflation tube 37/the pressure plate 18 and the liquid feeding tube 36 and is not sealed, the lower end of the inflation tube 37 extends out of the pressure plate 18 and is in a conical shape, and a plurality of gas injection ports 39 are arranged at the conical end of the inflation tube 37; the gas charging pipe 37 is provided with a gas charging pipe 38 vertical to the gas charging pipe, the gas charging pipe 38 penetrates through the pressure plate 18 to enable the gas charging pipe 37 and the pressure plate 18 to form a whole, and the gas charging pipe 37 is connected with an inert gas storage tank through the gas charging pipe. When filling, the filling opening can be connected with inert gas to fill the ampoule bottle.
Preferably, the filling mechanism further comprises a pressure plate lifting limiting block 23, and a gap is reserved between the pressure plate lifting limiting block 23 and the pressure plate 18 for the spring to buffer; the pressure plate lifting limiting block 23 is sleeved outside the liquid adding pipe 36, a spring 17 is sleeved outside the pressure plate lifting limiting block 23, the upper end of the spring 17 is embedded into the pressure plate lifting limiting block 23, and the lower end of the spring 17 is fixed at the top end of the pressure plate 18.
Preferably, a threaded hole is formed in the side wall of the pressure plate lifting limiting block 23, which is not sleeved with a spring, and a screw is installed in the threaded hole to tightly support the pressure plate lifting limiting block 23 and the pipette 16/liquid feeding pipe 36.
Further preferably, the lift arm fixing member 15 is provided with a screw hole, and a screw is installed in the screw hole to tightly support the lift arm fixing member 15 and the platen lift stopper 23, so that the distance between the platen lift stopper 23 and the platen can be adjusted according to circumstances.
As another preferred embodiment of the present invention, the lifting arm fixing member 15 and the platen lifting limiting block 23 are respectively provided with threaded holes, and screws sequentially pass through the threaded holes of the lifting arm fixing member 15 and the platen lifting limiting block 23 and are tightly supported by the pipette 16/the liquid feeding tube 36.
In the cleaning mechanism, the pre-wetting mechanism and the filling mechanism, the spring 17 is installed in the prior art, two ends of the spring 17 are respectively fixed with the pressure plate lifting limiting block 23 and the pressure plate 18, and the pressure plate is driven by the spring to move up and down along the liquid suction pipe/liquid feeding pipe during washing, wetting and filling operations so as to adapt to ampoule bottles with excessive specifications. The invention is suitable for washing, moistening and filling ampoule bottles with different specifications, and according to the maximum-size ampoule bottle, the pressure plate lifting limiting block 23 and the liquid injection pipe/liquid feeding pipe are adjusted, so that the adjustment of the highest lifting height of the mechanism is realized, and the bottom end of the liquid injection pipe/liquid feeding pipe is ensured to be close to the bottom of the ampoule bottle: when the washing and irrigating lifting arm 8 is lifted, the bottom end of the liquid injection pipe/liquid adding pipe is higher than the bottle opening of the ampoule bottle with the maximum specification, and when the liquid injection pipe/liquid adding pipe is lowered, the pressure plate can press the bottle opening of the ampoule bottle with the minimum specification, and the bottom of the liquid suction pipe/liquid adding pipe is close to the bottle bottom.
Preferably, the rotating shaft 31 is provided with a radial fixing screw 33, and the motor shaft 32 is fixed by the fixing screw 33 and the rotating shaft 31.
Preferably, the number of the L-shaped flame-spraying pipes 5 is 2, and the flame-spraying openings of the 2 flame-spraying pipes 5 are arranged oppositely and are positioned at two sides of the opening of the ampoule bottle.
Preferably, the sealing mechanism further comprises a fire-jet lifting sensor 35, and the fire-jet lifting sensor 35 is driven by the fire-jet lifting arm 3 to lift; the fire-jet lifting sensor 35 is slightly lower than the fire-jet of the fire-jet pipe 5 and points to the ampoule bottle mouth to be sealed by melting in the rotating mechanism. The high level is arranged in earlier to bocca lifing arm 3, treats that the ampoule of filling the liquid medicine is rotatory to rotatory sealing system department, and bocca lifing arm 3 descends, and bocca lifing sensor 35 detects the ampoule bottleneck, feeds back to control system, and control lifing arm 3 continues to descend take the altitude again, makes the bocca aim at rotatory ampoule bottleneck department suitable position and melts and seal.
The flaming port lifting sensor 35 is a light sensor, the triggering mode of the light sensor is various, such as light reflection type, light correlation type and the like, the prior art is adopted, and the light sensor can be selected according to specific conditions.
In the sealing mechanism, the positions of the flame-throwing tube 5 and the flame-throwing port lifting sensor 35 are relatively fixed, and the height of the flame-throwing port can be adjusted by the adjusting nut 4 aiming at ampoule bottles with different specifications.
The adjusting nut 4 is a self-locking nut.
The material of the flexible material sealing pad 19 and the flexible rotary suction cup 25 can be rubber or derivatives thereof, silica gel or derivatives thereof, and the like.
The integrated device for washing, moistening, filling and sealing the ampoule bottle can be controlled by a computer or a single chip microcomputer, and the washing, premoistening, filling and rotary melt sealing can be realized by the computer or the single chip microcomputer, which belongs to the prior art.
The ampoule bottle washing, moistening and filling and sealing integrated device provided by the invention is operated as follows:
(1) the ampoule bottle is directly placed in the self-adaptive clamping mechanism and automatically centered and fixed; the rotary table driving motor drives the rotary table to rotate so as to drive the ampoule bottles to slide on the fixed disc;
(2) the height of the washing, moistening and irrigating lifting arm is preset to be proper, when the washing, moistening and irrigating integrated system descends, the flexible sealing gasket presses the opening of the ampoule, the solvent is injected to the periphery of the liquid injection opening, the solvent can be completely attached to the inside of the ampoule, and then the solvent is sucked out through the liquid suction pipe, so that the cleaning effect is achieved for a small number of times; a gap is left between the pressure plate and the liquid suction pipe to ensure air backflow and smooth liquid extraction;
(3) the pre-moistening operation is performed in the same way as the cleaning operation in the step (2) by using liquid medicine, so that the residual solvent is completely replaced, and the concentration of the finally filled liquid medicine is not influenced;
(4) when filling, the liquid adding pipe is directly connected with a metering pump to quantitatively add liquid medicine, such as sensitive (easy oxidation and changeability) liquid medicine, and inert (protective) gas is filled through the inflation pipe;
(5) the bottom of an ampoule bottle filled with liquid medicine slides on the fixed disc and rotates to a rotary fusion sealing system, the negative pressure device is started, the sucking disc sucks the bottom of the ampoule bottle, the motor rotates to drive the ampoule bottle to rotate, a flame jet above the opening of the ampoule bottle automatically moves downwards, the position of the opening is detected by the sensor and then stops at a certain distance downwards, and the opening can be fused by using flames such as butane flame and oxyhydrogen flame to form hemispherical fusion sealing (non-wire drawing fusion sealing, no tail material drawing and more suitable for laboratories); and releasing the negative pressure after the sealing is finished, and separating the ampoule bottle from the soft rotary sucker.
In the ampoule bottle washing, moistening and filling integrated device, the filling mechanism and the cleaning mechanism/pre-moistening mechanism have the same structure, and only the liquid/gas circulation modes are different.
By adopting the ampoule bottle washing, moistening and filling and sealing integrated device, only cleaning, filling and sealing by melting can be carried out, only filling and sealing by melting can be carried out, and the functions of the cleaning mechanism, the pre-moistening mechanism and the filling mechanism can be adjusted according to the operation requirements.
Compared with the prior art, the invention has the beneficial effects that:
1. the invention combines washing, moistening and filling to achieve the aim of cleaning, pre-moistening and filling into a whole, and can fill protective gas to protect sensitive liquid medicine during filling;
2. according to the ampoule bottle lifting device, the self-adaptive clamping mechanism is matched with the flame-throwing port lifting sensor, so that ampoule bottles of different specifications can be synchronously operated;
3. the invention adopts the negative pressure to adsorb the ampoule bottle for rotary sealing, and realizes the hemispherical sealing without waste.
Drawings
FIG. 1 is a schematic structural view of a full-automatic ampoule bottle washing, moistening and filling integrated device;
FIG. 2 is a schematic structural diagram of the adaptive clamping mechanism;
FIG. 3 is a schematic diagram of the cleaning/pre-wetting mechanism;
FIG. 4 is a schematic view of the filling mechanism;
FIG. 5 is a schematic structural view of the rotating mechanism;
fig. 6 is a cross-sectional view of the rotary mechanism of fig. 5.
In the figure, 1-a host machine shell, 2-a stepping motor screw rod sliding table, 3-a fire spraying opening lifting arm, 4-an adjusting nut, 5-a fire spraying pipe, 6-a turntable driving motor, 7-a rotary sealing driving motor, 8-a washing and irrigating lifting arm, 9-an ampoule bottle, 10-an adaptive clamping mechanism, 11-a turntable, 12-an ampoule bottle hole site, 13-a slider groove, 14-a slider, 15-a lifting arm fixing part, 16-a pipette, 17-a spring, 18-a pressing plate, 19-a soft material sealing gasket, 20-a liquid inlet pipe, 21-a liquid injection pipe, 22-a liquid injection opening, 23-a pressing plate lifting limiting block, 24-a fixing plate, 25-a soft rotary sucker, 26-an air exhaust pipe and 27-a negative pressure air exhaust hole, 28-negative pressure annular sleeve, 29-sealing ring, 30-vent hole, 31-rotating shaft, 32-motor shaft, 33-fixing screw, 34-vent groove, 35-flame-throwing opening lifting sensor, 36-liquid feeding pipe, 37-inflation pipe, 38-air inlet pipe, 39-air-injecting opening and 40-flame-throwing pipe fixing piece.
Detailed Description
The technical solution of the present invention is further explained with reference to the specific embodiments.
Example 1
As shown in fig. 1-6, an ampoule bottle washing, moistening and filling integrated device includes a main machine case 1, a circular fixing disc 24, a disc-shaped turntable 11, a turntable driving motor 6, a washing, moistening and filling system and a rotary sealing system sequentially arranged along the rotation direction of the turntable 11, and 2 stepping motor screw rod sliding tables 2 respectively used for installing the washing, moistening and filling integrated system and the rotary sealing system.
The fixed disc 24 is fixed on the host machine shell 1 by a pillar; the rotary table 11 is positioned above the fixed table 24, a plurality of self-adaptive clamping mechanisms 10 for placing the ampoule bottles 9 are arranged along the circumferential direction of the rotary table 11, the self-adaptive clamping mechanisms 10 comprise ampoule bottle hole sites 12 penetrating through the rotary table 11, 3 slide block grooves 13 are uniformly arranged on the rotary table 11 along the radial direction of ampoule hole positions, the lower ends of the slide block grooves 13 are not communicated, two side walls of the slide block groove 13 are respectively provided with a radial limiting groove which is not communicated with the side wall of the ampoule bottle hole site 12, a slide block 14 is arranged in the slide block groove 13, two side walls of the slide block 14 are respectively provided with a limiting strip corresponding to the limiting groove, a spring is arranged between one end of the slide block 14 far away from the center of the ampoule hole site and the slide block groove, the ampoule bottle 9 is placed in the ampoule hole site 12 and supported by the fixed disc 24, under the action of a spring, one end of the sliding block, which is closer to the circle center of the ampoule hole site, is clamped to realize centering and fixing; the turntable driving motor 6 drives the turntable 11 to rotate, and the ampoule bottle is driven to slide on the fixed disk 24.
Wash and moisten an integrative system of irritating be located 11 tops of carousel, including curved wash and moisten and irritate lifing arm 8, wash and moisten and irritate lifing arm 8 and be driven by step motor lead screw slip table 2 and go up and down, wash and moisten and irritate lifing arm 8 and be equipped with wiper mechanism, moist mechanism and filling mechanism in advance, filling mechanism and wiper mechanism moist mechanism structure the same in advance, only liquid/gas circulation mode is different, in order to realize better washing and moist effect in advance, wiper mechanism and moist mechanism independent assortment in advance among the integrative system of infiltrating irrigation are washed to this embodiment, specifically, are equipped with in proper order along 11 direction of rotation of carousel: 1 wiper mechanism (water washing) +3 moisten mechanism +1 filling mechanism in advance, or 2 wiper mechanisms (be 1 methyl alcohol washing in proper order, 1 water washing) +2 moisten mechanism +1 filling mechanism in advance, or 3 wiper mechanisms (be 1 acetone washing +1 methyl alcohol washing in proper order, 1 water washing) +1 moisten mechanism +1 filling mechanism in advance.
The cleaning mechanism/pre-wetting mechanism comprises a lifting arm fixing piece 15, a pipette 16 and a liquid injection pipe 21, wherein one end of the lifting arm fixing piece 15 is fixed by a washing and wetting irrigation lifting arm 8, the other end of the lifting arm fixing piece 15 is provided with a pipette mounting hole and extends to the position above the self-adaptive clamping mechanism 10 along the radial direction, the pipette 16 is fixed by the lifting arm fixing piece 15, the bottom end of the pipette 16 can extend into an ampoule bottle, the top end of the pipette 16 is connected with a negative pressure bottle, the liquid injection pipe 21 is sleeved outside the middle part of the pipette 16 so that the liquid injection pipe 21 can slide up and down along the pipette 16, a pressure plate 18 is arranged outside the liquid injection pipe 21, a soft material sealing gasket 19 is arranged at the bottom end of the pressure plate 18, and a gap is left; the lower end of the liquid injection pipe 21 extends out of the pressure plate 18 and is conical, and a plurality of liquid injection ports 22 are formed in the conical end of the liquid injection pipe 21; the liquid injection pipe 21 is provided with a liquid inlet pipe 20 vertical to the liquid injection pipe, the liquid inlet pipe 20 penetrates through the pressure plate 18 to form the liquid injection pipe 21 and the pressure plate 18 into a whole, and the liquid inlet pipe 20 is connected with a storage tank filled with cleaning liquid or liquid medicine through an infusion pump; a pressure plate lifting limiting block 23 is sleeved outside the pipette 16, the top end of the pressure plate lifting limiting block 23 penetrates through the pipette mounting hole, the bottom end of the pressure plate lifting limiting block 23 is higher than the top end of the pressure plate 18 and is spaced from the top end of the pressure plate 18, a threaded hole is formed in the lifting arm fixing piece 15 corresponding to the pipette mounting hole, a screw support pressing plate lifting limiting block 23 is mounted in the hole, a threaded hole is formed in the side wall of the pressure plate lifting limiting block 23 higher than the lifting arm fixing piece 15, and the screw support pressing plate lifting limiting block 23 is mounted in the hole; a spring 17 is sleeved outside the pressure plate lifting limiting block 23, the upper end of the spring 17 is embedded into the pressure plate lifting limiting block 23, and the lower end of the spring 17 is fixed at the top end of the pressure plate 18; when cleaning/pre-wetting, the cleaning/pre-wetting lifting arm 8 descends, the pipette 16 extends into the ampoule bottle to be close to the bottle bottom, the flexible material sealing gasket 19 presses the ampoule bottle opening, cleaning liquid or liquid medicine is injected from the liquid injection opening 21 to the periphery to enable the ampoule bottle to be completely dipped in the solution, the pipette 16 sucks the solution, and the cleaning/pre-wetting effect is achieved for a small number of times.
The filling mechanism comprises a lifting arm fixing piece 15 and a liquid feeding pipe 36, one end of the lifting arm fixing piece 15 is fixed by a washing and moistening filling lifting arm 8, the other end of the lifting arm fixing piece is provided with a liquid feeding pipe mounting hole and radially extends to the position above the self-adaptive clamping mechanism 10, the liquid feeding pipe 36 is fixed by the lifting arm fixing piece 15, the bottom end of the liquid feeding pipe 36 can extend into an ampoule bottle, the top end of the liquid feeding pipe is connected with a storage tank filled with liquid medicine through a metering pump, a pressure plate 18 is arranged outside the middle part of the liquid feeding pipe 36 so that the pressure plate 18 can slide up and down along the liquid feeding pipe 36, and a soft material sealing; a pressure plate lifting limiting block 23 is sleeved outside the liquid adding pipe 36, the top end of the pressure plate lifting limiting block 23 penetrates through a liquid adding pipe mounting hole, the bottom end of the pressure plate lifting limiting block 23 is higher than the top end of the pressure plate 18 and is spaced from the top end of the pressure plate 18, a threaded hole is formed in the lifting arm fixing piece 15 corresponding to the liquid adding pipe mounting hole, a screw support pressing plate lifting limiting block 23 is installed in the hole, a threaded hole is formed in the side wall of the pressure plate lifting limiting block 23 higher than the lifting arm fixing piece 15, and the screw support pressing plate lifting limiting block 23 is installed in; a spring 17 is sleeved outside the pressure plate lifting limiting block 23, the upper end of the spring 17 is embedded into the pressure plate lifting limiting block 23, and the lower end of the spring 17 is fixed at the top end of the pressure plate 18; during filling, the liquid suction pipe is directly connected with a metering pump to quantitatively add the liquid medicine;
the rotary sealing system comprises a rotating mechanism and a sealing mechanism.
The rotating mechanism comprises a soft rotating sucker 25, a rotating shaft 31, a motor shaft 32 and a rotating fusion sealing driving motor 7, the soft rotating sucker 25 is fixed at the top end of the rotating shaft 31, the rotating shaft 31 is connected with the rotating fusion sealing driving motor 7 through the motor shaft 32, and a radial fixing screw 33 is arranged along the rotating shaft 31 to fix the motor shaft 32 and the rotating shaft 31; an annular sleeve 28 is sleeved outside the soft rotary sucker 25 and the rotating shaft 31, and the upper end of the annular sleeve 28 is embedded into the fixed disc 24 to realize fixation; an annular vent groove 34 is arranged along the outer wall of the rotating shaft 31, and sealing rings 29 are respectively arranged above and below the vent groove 34; an air suction hole 27 is arranged along the axes of the soft rotary sucker 25 and the rotating shaft 31 (the air suction hole penetrates through the soft rotary sucker 25 but does not penetrate through the rotating shaft 31), the air suction hole 27 is communicated with the vent groove 34 through a radial vent hole 30 in the rotating shaft 31, an air suction pipe 26 is arranged on the side wall of the annular sleeve 28 corresponding to the vent groove 34, the air suction pipe 26 is connected with a negative pressure device, and a negative pressure suction channel of 'air suction pipe-vent hole-vent groove-air suction hole' is formed during negative pressure suction. The sealing mechanism comprises a fire-jet lifting arm 3, a fire-jet pipe fixing piece 40, 2L-shaped fire-jet pipes 5 and a fire-jet lifting sensor 35; the fire-spraying port lifting arm 3 is connected with the stepping motor lead screw sliding table 2, the stepping motor lead screw sliding table 2 drives the fire-spraying port lifting arm 3 to lift, one end of the fire-spraying pipe fixing piece 40 is fixed on the fire-spraying port lifting arm 3, the other end of the fire-spraying pipe fixing piece extends to the upper part of the rotary table 11, the fire-spraying pipes 5 are fixed on the fire-spraying pipe fixing piece 40 through adjusting nuts 4, the fire-spraying ports of the 2 fire-spraying pipes 5 are oppositely arranged and are positioned on two sides of the opening of the ampoule bottle to be sealed by melting; the fire-jet lifting sensor 35 is fixed by the fire-jet lifting arm 3, the fire-jet lifting sensor 35 is slightly lower than the fire-jet of the fire-jet pipe 5 and points to the ampoule bottle mouth to be sealed by melting in the rotating mechanism. The ampoule bottle bottom of filling liquid medicine slides on the fixed disk, and rotatory to rotatory sealing system department that melts, negative pressure device start, and the sucking disc 25 holds at the bottom of the ampoule bottle, and the rotation of motor 7 drives the ampoule bottle rotatory, and automatic downstream of flame thrower mouth in ampoule bottle mouth top detects the bottleneck position by the sensor and stops to downward certain distance again, and flame such as available butane flame, oxyhydrogen flame burn the bottleneck, form the hemisphere and melt and seal.
Specifically, the adjusting nut 4 is a self-locking nut.
Adopt this embodiment ampoule to wash moist embedment integrated device, the operation is as follows:
(1) the ampoule bottle is directly placed in the self-adaptive clamping mechanism and automatically centered and fixed; the rotary table driving motor drives the rotary table to rotate so as to drive the ampoule bottles to slide on the fixed disc;
(2) the height of the washing, moistening and irrigating lifting arm is preset to be proper, when the washing, moistening and irrigating integrated system descends, the flexible sealing gasket presses the opening of the ampoule, the solvent is injected to the periphery of the liquid injection opening, the solvent can be completely attached to the inside of the ampoule, and then the solvent is sucked out through the liquid suction pipe, so that the cleaning effect is achieved for a small number of times;
(3) the pre-moistening operation is performed in the same way as the cleaning operation in the step (2) by using liquid medicine, so that the residual solvent is completely replaced, and the concentration of the finally filled liquid medicine is not influenced;
(4) when filling, the liquid adding pipe is directly connected with a metering pump to quantitatively add the liquid medicine;
(5) the bottom of an ampoule bottle filled with liquid medicine slides on the fixed disc and rotates to the position of the rotary sealing system, the negative pressure device is started, the sucking disc sucks the bottom of the ampoule bottle, the motor rotates to drive the ampoule bottle to rotate, the flame-throwing port above the opening of the ampoule bottle automatically moves downwards, the position of the opening of the ampoule bottle is detected by the sensor and then stops at a certain distance downwards, and the opening of the ampoule bottle can be fused by using flames such as butane flame, oxyhydrogen flame and the like to form hemispherical sealing; and releasing the negative pressure after the sealing is finished, and separating the ampoule bottle from the soft rotary sucker.
Example 2
In order to be suitable for filling sensitive liquid medicine, on the basis of embodiment 1, an inflation tube 37 is sleeved between the liquid feeding tube 36 and the pressure plate 18, the inflation tube 37 is connected with an inert gas storage tank through an air inlet tube 38, the lower end of the inflation tube extends out of the pressure plate 18 and is conical, and a plurality of air injection ports 39 are arranged at the conical end of the inflation tube. When filling, the filling opening can be connected with inert gas to fill the ampoule bottle.
Claims (8)
1. An ampoule bottle washing, moistening, filling and sealing integrated device is characterized by comprising a host machine shell, a fixed disc, a rotary disc driving motor, a washing, moistening and filling integrated system, a rotary melt-sealing system and 2 stepping motor lead screw sliding tables, wherein the washing, moistening and filling integrated system and the rotary melt-sealing system are sequentially arranged along the rotation direction of the rotary disc;
the fixed disc is fixed on the host machine shell by a support; the ampoule bottle is centered and fixed by the self-adaptive clamping mechanism and supported by the fixed disc; the rotary table driving motor drives the rotary table to rotate so as to drive the ampoule bottles to slide on the fixed disc; the self-adaptive clamping mechanism comprises ampoule bottle hole positions penetrating through the rotary table, at least 3 slider grooves are uniformly arranged on the rotary table along the radial direction of the ampoule bottle hole positions, and the lower ends of the slider grooves are not communicated; a sliding block is arranged in the sliding block groove, a spring is arranged between one end, far away from the center of the ampoule hole site, of the sliding block and the sliding block groove, the ampoule is placed in the ampoule hole site, and under the action of the spring, one end, close to the center of the ampoule hole site, of the sliding block is clamped to achieve centering and fixing;
the washing, moistening and irrigating integrated system is positioned above the turntable and comprises a washing, moistening and irrigating lifting arm, the washing, moistening and irrigating lifting arm is driven by a stepping motor lead screw sliding table to lift, and the washing, moistening and irrigating lifting arm is sequentially provided with a cleaning mechanism, a pre-moistening mechanism and a filling mechanism along the rotation direction of the turntable; the cleaning mechanism/pre-wetting mechanism comprises a lifting arm fixing piece, a liquid suction pipe and a liquid injection pipe, wherein the lifting arm fixing piece is fixed by a washing and wetting irrigation lifting arm and extends to the upper part of the self-adaptive clamping mechanism, the liquid suction pipe is fixed by the lifting arm fixing piece, and the bottom end of the liquid suction pipe can extend into an ampoule bottle and is close to the bottom of the ampoule bottle; the liquid injection pipe is sleeved outside the liquid suction pipe so that the liquid injection pipe can slide up and down along the liquid suction pipe, a pressure plate is arranged outside the liquid injection pipe, and a sealing gasket made of soft materials is arranged at the bottom end of the pressure plate; the lower end of the liquid injection pipe extends out of the pressure plate and is conical, and a plurality of liquid injection ports are formed in the conical end of the liquid injection pipe; the liquid injection pipe is provided with a liquid inlet pipe perpendicular to the liquid injection pipe, and the liquid inlet pipe penetrates through the pressure plate to form a whole with the pressure plate; the filling mechanism comprises a lifting arm fixing part and a liquid feeding pipe, the liquid feeding pipe is fixed by the lifting arm fixing part and extends to the upper part of the self-adaptive clamping mechanism, the bottom end of the liquid feeding pipe can extend into an ampoule bottle, a pressure plate is sleeved outside the liquid feeding pipe to enable the pressure plate to slide up and down along the liquid feeding pipe, and a soft material sealing gasket is arranged at the bottom end of the pressure plate; an inflation tube is sleeved between the liquid feeding tube and the pressure plate to enable the inflation tube to slide up and down along the liquid feeding tube, the lower end of the inflation tube extends out of the pressure plate and is conical, and a plurality of gas injection ports are formed in the conical end of the inflation tube; the gas charging pipe is provided with a gas inlet pipe vertical to the gas charging pipe, the gas inlet pipe penetrates through the pressure plate to enable the gas charging pipe and the pressure plate to form a whole, and the gas charging pipe is connected with the inert gas storage tank through the gas inlet pipe;
the rotary sealing system comprises a rotating mechanism and a sealing mechanism; the rotary mechanism comprises a soft rotary sucker, a rotary shaft, a motor shaft and a rotary sealing driving motor, the soft rotary sucker is fixed at the top end of the rotary shaft, the rotary shaft is connected with the rotary sealing driving motor through the motor shaft, annular sleeves are sleeved on the outer sides of the soft rotary sucker and the rotary shaft, and the upper ends of the annular sleeves are embedded into a fixed disc to realize fixation; the rotating shaft is provided with an annular vent groove, and the upper part and the lower part of the vent groove are respectively provided with a sealing ring; an air exhaust hole is arranged along the axes of the flexible rotary sucker and the rotating shaft, the air exhaust hole is communicated with the vent groove through an inner radial vent hole of the rotating shaft, an air exhaust pipe is arranged on the side wall of the annular sleeve corresponding to the vent groove, and the air exhaust pipe is connected with a negative pressure device; the sealing mechanism comprises a fire-spraying port lifting arm, a fire-spraying pipe fixing part and at least 1L-shaped fire-spraying pipe, wherein the fire-spraying port lifting arm is driven to lift by a stepping motor lead screw sliding table, the fire-spraying pipe fixing part is fixed on the fire-spraying port lifting arm, and the fire-spraying pipe is fixed on the fire-spraying pipe fixing part by an adjusting nut.
2. The integrated ampoule bottle washing, moistening, filling and sealing device according to claim 1, wherein the fixing disc is annular; the fixed disk is fixed on the host machine shell by at least 3 struts along the circumferential direction.
3. The integrated ampoule bottle washing, moistening, filling and sealing device according to claim 1, wherein two side walls of the slider groove are respectively provided with a radial limiting groove which is not communicated with the ampoule bottle hole site side wall, two side walls of the slider are respectively provided with a limiting strip corresponding to the limiting groove, and the limiting strips are arranged in the limiting grooves.
4. The integrated ampoule bottle washing, moistening, filling and sealing device according to claim 1, wherein the washing mechanism/pre-moistening mechanism further comprises a platen lifting limiting block, the platen lifting limiting block is sleeved outside the liquid suction pipe, a spring is sleeved outside the platen lifting limiting block, the upper end of the spring is embedded into the platen lifting limiting block, and the lower end of the spring is fixed at the top end of the platen; the pressure plate lifting limiting block and the pressure plate are spaced for the spring to buffer.
5. The integrated ampoule bottle washing, moistening, filling and sealing device according to claim 1, wherein the filling mechanism further comprises a platen lifting limiting block, and a gap is reserved between the platen lifting limiting block and the platen; the pressure plate lifting limiting block is sleeved outside the liquid adding pipe, a spring is sleeved outside the pressure plate lifting limiting block, the upper end of the spring is embedded into the pressure plate lifting limiting block, and the lower end of the spring is fixed to the top end of the pressure plate.
6. The integrated ampoule bottle washing, moistening, filling and sealing device according to claim 4 or 5, wherein a threaded hole is formed in a side wall of the pressure plate lifting limiting block, which is not sleeved with a spring, and a screw is installed in the threaded hole to tightly support the pressure plate lifting limiting block and the pipette/liquid feeding pipe; the lifting arm fixing piece is provided with a threaded hole, and a screw is arranged in the threaded hole to tightly support the lifting arm fixing piece and the pressure plate lifting limiting block.
7. The integrated ampoule bottle washing, moistening, filling and sealing device according to claim 1, wherein the rotating shaft is provided with radial fixing screws, and the motor shaft is fixed by the fixing screws and the rotating shaft.
8. The integrated ampoule bottle rinsing, filling and sealing device according to claim 1, wherein the sealing mechanism further comprises a burner elevating sensor, and the burner elevating sensor is driven by a burner elevating arm to ascend and descend; the fire-jet lifting sensor is lower than the fire-jet of the fire-jet pipe and points to the ampoule bottle mouth to be sealed by melting in the rotating mechanism.
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| CN202010042155.7A CN111170256B (en) | 2020-01-15 | 2020-01-15 | Ampoule washing, moistening, filling and sealing integrated device |
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| CN202010042155.7A CN111170256B (en) | 2020-01-15 | 2020-01-15 | Ampoule washing, moistening, filling and sealing integrated device |
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| CN111170256A CN111170256A (en) | 2020-05-19 |
| CN111170256B true CN111170256B (en) | 2021-07-06 |
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| CN112722356B (en) * | 2020-12-22 | 2022-12-16 | 石药银湖制药有限公司 | Ampoule melts and seals all-in-one |
| CN115068419A (en) * | 2022-07-22 | 2022-09-20 | 潍坊恒邦兽药有限公司 | Veterinary high-concentration meloxicam injection and processing equipment thereof |
| CN115557682B (en) * | 2022-12-03 | 2023-03-07 | 坛墨质检科技股份有限公司 | Ampoule bottle sealing device and method for volatile organic standard solution |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN2813578Y (en) * | 2005-05-16 | 2006-09-06 | 湖南千山制药机械股份有限公司 | Intermittent rotary type plastic bottle-washing, filling and sealing machine |
| CN201962189U (en) * | 2010-12-27 | 2011-09-07 | 青岛高科技工业园海博生物技术有限公司 | Ampoule bottle heat sealing machine |
| CN103128088A (en) * | 2011-11-24 | 2013-06-05 | 苏州列维电器设备有限公司 | Automatic bottle-washing machine and automatic bottle-washing device |
| CN103508662A (en) * | 2012-06-21 | 2014-01-15 | 四川制药制剂有限公司 | Melt sealing system able to perform rapid gripping |
| CN104340942A (en) * | 2014-09-23 | 2015-02-11 | 长沙汇一制药机械有限公司 | Transfusion container production line |
| CN106082090B (en) * | 2016-08-09 | 2018-10-02 | 江苏华鸣生物科技有限公司 | A kind of ampoule bottle wire drawing encapsulating device |
| CN208454807U (en) * | 2018-01-16 | 2019-02-01 | 扬州大晟药用玻璃有限公司 | A kind of bottle body device for clamping and rotating of ampoule bottle heat sealing machine |
| CN108529542A (en) * | 2018-04-02 | 2018-09-14 | 瞿仁芬 | A kind of cosmetics processing auto-filling packing equipment integrating |
| CN208466783U (en) * | 2018-04-24 | 2019-02-05 | 贵州光正制药有限责任公司 | A kind of ampoule bottle high pressure carbonated drink jet cleaning head |
| CN109354394B (en) * | 2018-10-12 | 2021-11-12 | 湖北新华光信息材料有限公司 | Quartz ampoule bottle fusion sealing device and method |
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