CN111166355B - 一种小鼠焦虑样行为检测装置 - Google Patents

一种小鼠焦虑样行为检测装置 Download PDF

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CN111166355B
CN111166355B CN202010105356.7A CN202010105356A CN111166355B CN 111166355 B CN111166355 B CN 111166355B CN 202010105356 A CN202010105356 A CN 202010105356A CN 111166355 B CN111166355 B CN 111166355B
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李建国
李玥天
燕子
王锐
张倩
史晋朝
张升校
赵欣
张宇
张策
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Abstract

本发明公开了一种小鼠焦虑样行为检测装置,包括有筒体以及电击发生器,所述筒体由外筒、内筒组成,所述内筒与外筒之间固定设置有底板,所述底板由多块形状相同的扇环形金属导电平板组成,相邻两块扇环形金属导电平板之间设置有间隔,以保证相互绝缘,通过所述扇环形金属导电平板使得所述底板形成连续的不同测试区域,所述电击发生器通过导线分别与所述扇环形金属导电平板连接,以使小鼠跨越相邻两块扇环形金属导电平板间隔时,受到一定强度的电流刺激,感到不适或疼痛。本发明提供的一种小鼠焦虑样行为检测装置,可以更加准确地反映小鼠的焦虑程度。

Description

一种小鼠焦虑样行为检测装置
技术领域
本发明涉及实验研究用装置技术领域,尤其涉及一种小鼠焦虑样行为检测装置。
背景技术
焦虑是由潜在伤害性刺激引起机体产生的情绪反应。主要表现为紧张、不安和恐慌感等情绪变化,同时伴有心率加快、呼吸急促、发汗等自主神经功能变化,以及防御和回避等行为改变。许多精神性疾病,如抑郁症、强迫性精神障碍、创伤后应激障碍、广泛性焦虑障碍等,均有焦虑症状的表现。
小鼠具有对新奇环境的天然探索本能和对高度、空旷、亮光、疼痛等天然的回避本能,所以成为研究焦虑的主要实验小鼠。目前已有高架十字迷宫、旷场实验、黑白箱和四板测试仪等多种焦虑样行为检测装置。在这些检测方法中,利用小鼠的探索本能和回避本能之间的矛盾,从行为上检测其焦虑程度,焦虑小鼠表现为回避行为增加而探索行为减少。但是,在上述焦虑样行为检测方法中,小鼠所需要探索新奇环境的特点单一(单一的十字臂、单一的旷场、单一的光照和单一的平板等),容易使小鼠产生适应,不能够持续诱导小鼠发挥探索新奇环境的本能。因此,在上述环境中,小鼠的探索行为减少属于适应性减少,并不与回避行为的增加密切相关,所以不能准确反映小鼠的焦虑程度。为了更好地探索焦虑在多种精神性疾病中的作用,设计一种相对准确的小鼠焦虑样行为检测装置显得尤为重要。
发明内容
为解决现有技术的缺点和不足,提供一种小鼠焦虑样行为检测装置,从而更加准确地反映小鼠的焦虑程度。
为实现本发明目的而提供的一种小鼠焦虑样行为检测装置,包括有筒体以及电击发生器,所述筒体由外筒、内筒组成,所述内筒与外筒之间固定设置有底板,所述底板由多块形状相同的扇环形金属导电平板组成,相邻两块扇环形金属导电平板之间设置有间隔,以保证相互绝缘,通过所述扇环形金属导电平板使得所述底板形成连续的不同测试区域,所述电击发生器通过导线分别与所述扇环形金属导电平板连接,以使小鼠跨越相邻两块扇环形金属导电平板间隔时,受到一定强度的电流刺激,感到不适或疼痛,电击刺激为手动控制,当小鼠两前肢跨越间隔进入另一测试区域后,立即启动电击,刺激电流大小和持续时间由电击发生器调控,在跨越底板上的间隔时候,小鼠受到电击刺激并感到不适疼痛,记录1min内小鼠跨越底板上的间隔的次数可以准确反映小鼠的焦虑程度,小鼠的跨越次数越少表明焦虑程度越高;
所述扇环形金属导电平板设置有四块,将所述底板形成四个测试区域,第一测试区域为每次放入小鼠的测试区域;第二测试区域的扇环形金属导电平板中有三个垂直贯穿其上下端面的孔洞,孔洞分散分布;第三测试区域的扇环形金属导电平板表面有三个平行于底板半径方向的横向圆筒,一个横向圆筒贯穿内筒壁,两个横向圆筒分散分布并且贯穿外筒壁;第四测试区域的扇环形金属导电平板表面有三个分散分布的纵向圆筒。
作为上述方案的进一步改进,所述所述外筒直径为60cm,高度为45cm,内筒直径为20cm,高度为30cm,所述外筒与内筒的上端面齐平,所述底板与所述内筒的下端面齐平,所述底板距离外筒的下端面15cm。
作为上述方案的进一步改进,所述横向圆筒的长度为3cm,直径为3cm;所述纵向圆筒的高度为3cm,直径为3cm。
作为上述方案的进一步改进,所述外筒与内筒为PVC材质构成的套筒样结构。
本发明的有益效果是:
与现有技术相比,本发明提供的一种小鼠焦虑样行为检测装置,在使用的时候,将小鼠放置第一测试区域,内筒与外筒之间是一个环形活动区域,底板上的间隔不会影响小鼠的跨越穿梭,小鼠有观察探索新奇环境和探洞的特性,小鼠会探索周围环境,并跨越相邻的扇环形金属导电平板,电击刺激为手动控制,当小鼠两前肢跨越间隔进入另一测试区域后,立即启动电击,刺激电流大小和持续时间由电击发生器调控,在跨越底板上的间隔时候,小鼠受到电击刺激并感到不适疼痛,由于本装置的测试区域特点不同, 能够持续引起小鼠的新奇感和探洞行为,从而诱导小鼠持续跨越底板上的间隔并受到电击刺激,焦虑后的小鼠对新奇环境和孔洞的探索行为减少,同时对电击刺激的回避行为增加,所以跨越底板上的间隔的次数减少。记录1min内小鼠跨越底板上的间隔的次数可以准确反映小鼠的焦虑程度,小鼠的跨越次数越少表明焦虑程度越高。
此装置不容易让小鼠产生环境适应而减少探索行为,检测到的探索行为减少与小鼠受电击刺激后的回避行为密切相关,所以更能准确反映小鼠的焦虑程度。
附图说明
以下结合附图对本发明的具体实施方式作进一步的详细说明,其中:
图1 为本发明的结构示意图;
图2 为本发明的筒体的俯视图。
实施方式
如图1-图2所示,本发明提供的一种小鼠焦虑样行为检测装置,包括有筒体以及电击发生器12,筒体由外筒1、内筒2组成,外筒1直径为60cm,高度为45cm,内筒2直径为20cm,高度为30cm,外筒1与内筒2的上端面齐平,内筒2与外筒1之间固定设置有底板,底板与内筒2的下端面齐平,底板距离外筒1的下端面15cm。底板由多块形状相同的扇环形金属导电平板组成,相邻两块扇环形金属导电平板之间设置有间隔6,以保证相互绝缘,通过扇环形金属导电平板使得底板形成连续的不同测试区域,电击发生器12通过导线11分别与扇环形金属导电平板连接,可以提供刺激时间0-10s、刺激强度0-10mA的方波电流刺激,以使小鼠跨越相邻两块扇环形金属导电平板的间隔6时,受到一定强度的电流刺激,感到不适或疼痛。
具体地,扇环形金属导电平板设置有四块,将底板形成四个测试区域,第一测试区域3为每次放入小鼠的测试区域;第二测试区域4的扇环形金属导电平板中有三个垂直贯穿其上下端面的孔洞5,孔洞5分散分布;第三测试区域7的扇环形金属导电平板表面有三个平行于底板半径方向的横向圆筒10,横向圆筒10的长度为3cm,直径为3cm;一个横向圆筒10贯穿内筒2的侧壁,两个横向圆筒10分散分布并且贯穿外筒1的侧壁;第四测试区域8的扇环形金属导电平板表面有三个分散分布的纵向圆筒9,纵向圆筒9的高度为3cm,直径为3cm。
本发明中外筒1与内筒2为PVC材质构成的套筒样结构。
以上实施例不局限于该实施例自身的技术方案,实施例之间可以相互结合成新的实施例。以上实施例仅用以说明本发明的技术方案而并非对其进行限制,凡未脱离本发明精神和范围的任何修改或者等同替换,其均应涵盖在本发明技术方案的范围内。

Claims (4)

1.一种小鼠焦虑样行为检测装置,其特征在于:包括有筒体以及电击发生器,所述筒体由外筒、内筒组成,所述内筒与外筒之间固定设置有底板,所述底板由多块形状相同的扇环形金属导电平板组成,相邻两块扇环形金属导电平板之间设置有间隔,以保证相互绝缘,通过所述扇环形金属导电平板使得所述底板形成连续的不同测试区域,所述电击发生器通过导线分别与多块所述扇环形金属导电平板连接,以使小鼠跨越相邻两块扇环形金属导电平板间隔时,受到一定强度的电流刺激,感到不适或疼痛,电击刺激为手动控制,当小鼠两前肢跨越间隔进入另一测试区域后,立即启动电击,刺激电流大小和持续时间由电击发生器调控,在跨越底板上的间隔时候,小鼠受到电击刺激并感到不适疼痛,记录1min内小鼠跨越底板上的间隔的次数可以准确反映小鼠的焦虑程度,小鼠的跨越次数越少表明焦虑程度越高;
所述扇环形金属导电平板设置有四块,将所述底板形成四个测试区域,第一测试区域为每次放入小鼠的测试区域;第二测试区域的扇环形金属导电平板中有三个垂直贯穿其上下端面的孔洞,孔洞分散分布;第三测试区域的扇环形金属导电平板表面有三个平行于底板半径方向的横向圆筒,一个横向圆筒贯穿内筒壁,两个横向圆筒分散分布并且贯穿外筒壁;第四测试区域的扇环形金属导电平板表面有三个分散分布的纵向圆筒。
2.根据权利要求1所述的一种小鼠焦虑样行为检测装置,其特征在于:所述外筒直径为60cm,高度为45cm,内筒直径为20cm,高度为30cm,所述外筒与内筒的上端面齐平,所述底板与所述内筒的下端面齐平,所述底板距离外筒的下端面15cm。
3.根据权利要求2所述的一种小鼠焦虑样行为检测装置,其特征在于:所述横向圆筒的长度为3cm,直径为3cm;所述纵向圆筒的高度为3cm,直径为3cm。
4.根据权利要求1-3中任一所述的一种小鼠焦虑样行为检测装置,其特征在于:所述外筒与内筒为PVC材质构成的套筒样结构。
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